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Aliases for CINP Gene

Aliases for CINP Gene

  • Cyclin Dependent Kinase 2 Interacting Protein 2 3 5
  • CDK2-Interacting Protein 4

External Ids for CINP Gene

Previous GeneCards Identifiers for CINP Gene

  • GC14M100200
  • GC14M096630
  • GC14M100798
  • GC14M101878
  • GC14M102814
  • GC14M082991
  • GC14M102808

Summaries for CINP Gene

Entrez Gene Summary for CINP Gene

  • The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for CINP Gene

CINP (Cyclin Dependent Kinase 2 Interacting Protein) is a Protein Coding gene. Diseases associated with CINP include Dysthymic Disorder.

UniProtKB/Swiss-Prot for CINP Gene

  • Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CINP Gene

Genomics for CINP Gene

Regulatory Elements for CINP Gene

Enhancers for CINP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F102315 1.4 Ensembl ENCODE 17.7 +43.1 43126 7.7 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 RCOR1 CINP TECPR2 RPL26P4 ZNF839 CDC42BPB ENSG00000258959 ENSG00000259515 ENSG00000271780 GC14P102747
GH14F102522 1.8 FANTOM5 Ensembl ENCODE 10.5 -163.2 -163178 6.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 RCOR1 TECPR2 RPL23AP11 MOK ANKRD9 TRAF3 DIO3 ENSG00000271780 RNU6-244P DIO3OS
GH14F102538 1.3 Ensembl ENCODE 10.5 -176.9 -176941 2.9 ATF1 PKNOX1 ARID4B DMAP1 ZNF48 YY1 SLC30A9 GLIS2 SP5 NFYC RCOR1 CINP TECPR2 WDR20 MIR4309 LOC105370681
GH14F102507 1.3 FANTOM5 ENCODE 10.4 -146.9 -146943 4.9 ATF1 PKNOX1 ZNF133 ARID4B SIN3A DMAP1 ZNF48 ZNF121 SLC30A9 GLIS2 ANKRD9 RCOR1 CINP TECPR2 ZNF839 AMN LOC105370679
GH14F102262 1.2 Ensembl ENCODE 10.5 +99.1 99103 3.3 ELF3 ZFP64 DMAP1 THRB ZNF48 RARA ZNF121 SCRT2 MIXL1 ZNF202 MOK CINP TECPR2 HSP90AA1 WDR20 GC14P102745 GC14P102750
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CINP on UCSC Golden Path with GeneCards custom track

Promoters for CINP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000100006 -84 2001 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 ZNF143

Genomic Location for CINP Gene

Chromosome:
14
Start:
102,341,102 bp from pter
End:
102,362,916 bp from pter
Size:
21,815 bases
Orientation:
Minus strand

Genomic View for CINP Gene

Genes around CINP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CINP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CINP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CINP Gene

Proteins for CINP Gene

  • Protein details for CINP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW66-CINP_HUMAN
    Recommended name:
    Cyclin-dependent kinase 2-interacting protein
    Protein Accession:
    Q9BW66
    Secondary Accessions:
    • F5H7P3
    • F5H8A7
    • Q9NPF9

    Protein attributes for CINP Gene

    Size:
    212 amino acids
    Molecular mass:
    24324 Da
    Quaternary structure:
    • Homodimer. Interacts with CDK2 and CDC7. Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes. Interacts with ATRIP. Interacts with CEP152.
    SequenceCaution:
    • Sequence=BU174070; Type=Frameshift; Positions=183, 197; Evidence={ECO:0000305};

    Alternative splice isoforms for CINP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CINP Gene

Post-translational modifications for CINP Gene

Other Protein References for CINP Gene

No data available for DME Specific Peptides for CINP Gene

Domains & Families for CINP Gene

Protein Domains for CINP Gene

Suggested Antigen Peptide Sequences for CINP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW66

UniProtKB/Swiss-Prot:

CINP_HUMAN :
  • Belongs to the CINP family.
Family:
  • Belongs to the CINP family.
genes like me logo Genes that share domains with CINP: view

No data available for Gene Families for CINP Gene

Function for CINP Gene

Molecular function for CINP Gene

UniProtKB/Swiss-Prot Function:
Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.

Gene Ontology (GO) - Molecular Function for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21131973
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CINP: view
genes like me logo Genes that share phenotypes with CINP: view

Animal Models for CINP Gene

MGI Knock Outs for CINP:
  • Cinp tm1.1(KOMP)Vlcg

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CINP Gene

Localization for CINP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CINP Gene

Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CINP gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CINP: view

Pathways & Interactions for CINP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007049 cell cycle IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CINP: view

No data available for Pathways by source and SIGNOR curated interactions for CINP Gene

Drugs & Compounds for CINP Gene

(3) Drugs for CINP Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Quercetin Experimental Nutra Antitumor agent 40
Antioxidants Pharma 2928
Protective Agents Pharma 7190

(2) Additional Compounds for CINP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-hydroxyoctadecanoyl-CoA
  • 3-Hydroxyoctadecanoyl-coenzyme A
  • 3-Hydroxystearoyl-CoA
  • 3-Hydroxystearoyl-Coenzyme A
  • beta-Hydroxystearoyl-coa
  • beta-Hydroxystearyl-coa
42578-91-6
Docosanoyl-CoA
  • Behenoyl-CoA
  • Behenoyl-Coenzyme A
genes like me logo Genes that share compounds with CINP: view

Transcripts for CINP Gene

Unigene Clusters for CINP Gene

Cyclin-dependent kinase 2 interacting protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CINP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7:
SP8:

Relevant External Links for CINP Gene

GeneLoc Exon Structure for
CINP
ECgene alternative splicing isoforms for
CINP

Expression for CINP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CINP Gene

Protein differential expression in normal tissues from HIPED for CINP Gene

This gene is overexpressed in Retina (47.9), CD8 Tcells (14.5), and Placenta (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CINP Gene



Protein tissue co-expression partners for CINP Gene

NURSA nuclear receptor signaling pathways regulating expression of CINP Gene:

CINP

SOURCE GeneReport for Unigene cluster for CINP Gene:

Hs.129634
genes like me logo Genes that share expression patterns with CINP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CINP Gene

Orthologs for CINP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CINP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CINP 34 35
  • 99.21 (n)
cow
(Bos Taurus)
Mammalia CINP 34 35
  • 82.86 (n)
dog
(Canis familiaris)
Mammalia CINP 34 35
  • 82.39 (n)
mouse
(Mus musculus)
Mammalia Cinp 34 16 35
  • 79.09 (n)
rat
(Rattus norvegicus)
Mammalia Cinp 34
  • 78.62 (n)
oppossum
(Monodelphis domestica)
Mammalia CINP 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CINP 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CINP 34 35
  • 67.31 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cinp 34
  • 59.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15051 34
zebrafish
(Danio rerio)
Actinopterygii LOC100003640 34
  • 57.43 (n)
cinp 35
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6870 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToOne
Species where no ortholog for CINP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CINP Gene

ENSEMBL:
Gene Tree for CINP (if available)
TreeFam:
Gene Tree for CINP (if available)

Paralogs for CINP Gene

No data available for Paralogs for CINP Gene

Variants for CINP Gene

Sequence variations from dbSNP and Humsavar for CINP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_039980 A colorectal cancer sample
rs10139128 -- 102,364,623(+) GCTTT(G/T)GTTAG intron-variant, upstream-variant-2KB
rs10143246 -- 102,345,600(+) gtgat(C/T)ctacc intron-variant
rs10145596 -- 102,345,812(+) TTAtt(A/T)ttttt intron-variant
rs1047409 -- 102,348,402(-) CCAGG(C/G)GTGCT nc-transcript-variant, utr-variant-3-prime

Variation tolerance for CINP Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.63; 82.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CINP Gene

Human Gene Mutation Database (HGMD)
CINP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CINP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CINP Gene

Disorders for CINP Gene

MalaCards: The human disease database

(1) MalaCards diseases for CINP Gene - From: DISEASES

Disorder Aliases PubMed IDs
dysthymic disorder
  • dysthymia
- elite association - COSMIC cancer census association via MalaCards
Search CINP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CINP

Genetic Association Database (GAD)
CINP
Human Genome Epidemiology (HuGE) Navigator
CINP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CINP
genes like me logo Genes that share disorders with CINP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CINP Gene

Publications for CINP Gene

  1. A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes. (PMID: 16082200) Grishina I. … Lattes B. (Cell Cycle 2005) 2 3 4 64
  2. CEP152 is a genome maintenance protein disrupted in Seckel syndrome. (PMID: 21131973) Kalay E. … Wollnik B. (Nat. Genet. 2011) 3 4 64
  3. Functional genomic screens identify CINP as a genome maintenance protein. (PMID: 19889979) Lovejoy C.A. … Cortez D. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CINP Gene

Sources for CINP Gene

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