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Aliases for CILP2 Gene

Aliases for CILP2 Gene

  • Cartilage Intermediate Layer Protein 2 2 3 5
  • CILP-2 3 4
  • Cartilage Intermediate Layer Protein-Like Protein 2 3
  • CLIP-2 3

External Ids for CILP2 Gene

Previous GeneCards Identifiers for CILP2 Gene

  • GC19P019473
  • GC19P019511
  • GC19P019649
  • GC19P019211

Summaries for CILP2 Gene

GeneCards Summary for CILP2 Gene

CILP2 (Cartilage Intermediate Layer Protein 2) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and nucleotide diphosphatase activity. An important paralog of this gene is CILP.

UniProtKB/Swiss-Prot for CILP2 Gene

  • May play a role in cartilage scaffolding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CILP2 Gene

Genomics for CILP2 Gene

Regulatory Elements for CILP2 Gene

Enhancers for CILP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F020077 1 Ensembl ENCODE 4.7 +542.5 542467 6.8 PKNOX1 USF1 SAP130 ARID4B MAX ZSCAN9 YY1 POLR2A GATAD1 NFYB ZNF682 BNIP3P15 CILP2 MEF2B ZNF506 LOC100419301 BNIP3P14
GH19F019538 0.7 ENCODE 0.8 0.0 -12 0.2 KLF1 ZNF223 ZNF76 KLF17 ZIC2 ZFHX2 GLIS2 POLR2A PATZ1 ZNF600 CILP2 GC19M019535
GH19F019543 0.7 ENCODE 0.8 +2.3 2329 0.2 KLF1 CBX3 USF1 L3MBTL2 BHLHE40 TFDP1 POLR2A IRF1 KLF8 E2F6 CILP2 GC19M019560
GH19F019540 0.6 ENCODE 0.8 +2.6 2609 0.2 TFDP1 KLF1 IRF1 KLF8 TCF7L2 CILP2 GC19M019560
GH19F019541 0.6 ENCODE 0.8 +3.1 3089 0.2 SP1 PKNOX1 SP3 NRF1 SP2 IRF1 NDUFA13 CILP2 GC19M019560
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CILP2 on UCSC Golden Path with GeneCards custom track

Promoters for CILP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001816702 -748 201 ZBTB7A

Genomic Location for CILP2 Gene

19,538,248 bp from pter
19,546,659 bp from pter
8,412 bases
Plus strand

Genomic View for CILP2 Gene

Genes around CILP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CILP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CILP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CILP2 Gene

Proteins for CILP2 Gene

  • Protein details for CILP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cartilage intermediate layer protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6NV88
    • Q8N4A6
    • Q8WV21

    Protein attributes for CILP2 Gene

    1156 amino acids
    Molecular mass:
    126291 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CILP2 Gene

Post-translational modifications for CILP2 Gene

  • May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.
  • Glycosylation at Thr 236, Asn 276, Asn 308, and Asn 329
  • Modification sites at PhosphoSitePlus

Other Protein References for CILP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CILP2
  • Santa Cruz Biotechnology (SCBT) Antibodies for CILP2

No data available for DME Specific Peptides for CILP2 Gene

Domains & Families for CILP2 Gene

Gene Families for CILP2 Gene

Suggested Antigen Peptide Sequences for CILP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 TSP type-1 domain.
genes like me logo Genes that share domains with CILP2: view

Function for CILP2 Gene

Molecular function for CILP2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cartilage scaffolding.

Gene Ontology (GO) - Molecular Function for CILP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004035 NOT alkaline phosphatase activity IDA 12746903
GO:0004551 NOT nucleotide diphosphatase activity IDA 12746903
genes like me logo Genes that share ontologies with CILP2: view
genes like me logo Genes that share phenotypes with CILP2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CILP2 Gene

Localization for CILP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CILP2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CILP2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CILP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CILP2: view

Pathways & Interactions for CILP2 Gene

SuperPathways for CILP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CILP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CILP2 Gene

Transcripts for CILP2 Gene

mRNA/cDNA for CILP2 Gene

Unigene Clusters for CILP2 Gene

Cartilage intermediate layer protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CILP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - -
SP2: - - -
SP4: -

Relevant External Links for CILP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CILP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CILP2 Gene

mRNA differential expression in normal tissues according to GTEx for CILP2 Gene

This gene is overexpressed in Testis (x14.3).

Protein differential expression in normal tissues from HIPED for CILP2 Gene

This gene is overexpressed in Urine (43.5), Serum (15.2), and Heart (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CILP2 Gene

Protein tissue co-expression partners for CILP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CILP2 Gene:


SOURCE GeneReport for Unigene cluster for CILP2 Gene:


mRNA Expression by UniProt/SwissProt for CILP2 Gene:

Tissue specificity: Expressed in articular chondrocytes but not in knee meniscal cartilage cells (PubMed:12746903). Localizes to the intermediate to deep zone of articular cartilage (PubMed:21880736).
genes like me logo Genes that share expression patterns with CILP2: view

Primer Products

Orthologs for CILP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CILP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CILP2 34 35
  • 99.39 (n)
(Canis familiaris)
Mammalia CILP2 34 35
  • 87.2 (n)
(Bos Taurus)
Mammalia CILP2 34 35
  • 85.93 (n)
(Rattus norvegicus)
Mammalia Cilp2 34
  • 78.36 (n)
(Mus musculus)
Mammalia Cilp2 34 16 35
  • 77.64 (n)
(Ornithorhynchus anatinus)
Mammalia CILP2 35
  • 68 (a)
(Monodelphis domestica)
Mammalia CILP2 35
  • 64 (a)
(Gallus gallus)
Aves CILP2 34 35
  • 69.99 (n)
(Anolis carolinensis)
Reptilia CILP2 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cilp2 34
  • 56.8 (n)
(Danio rerio)
Actinopterygii cilp2 34 35
  • 57.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
Species where no ortholog for CILP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CILP2 Gene

Gene Tree for CILP2 (if available)
Gene Tree for CILP2 (if available)

Paralogs for CILP2 Gene

Paralogs for CILP2 Gene

(1) SIMAP similar genes for CILP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CILP2: view

Variants for CILP2 Gene

Sequence variations from dbSNP and Humsavar for CILP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1036215 -- 19,546,389(-) AGGCA(A/G)AGGGG utr-variant-3-prime
rs10401822 -- 19,538,198(+) AGGGC(C/T)AGGGG upstream-variant-2KB
rs10402308 -- 19,546,691(+) AGGAT(A/G)GAGGC downstream-variant-500B
rs1054930 -- 19,537,537(+) CCGCG(C/G)CCACA upstream-variant-2KB, utr-variant-3-prime
rs10664406 -- 19,542,716(+) CTCGA(-/AG)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CILP2 Gene

Variant ID Type Subtype PubMed ID
nsv509723 CNV insertion 20534489
nsv952426 CNV deletion 24416366

Variation tolerance for CILP2 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CILP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CILP2 Gene

Disorders for CILP2 Gene

Relevant External Links for CILP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CILP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CILP2 Gene

Publications for CILP2 Gene

  1. One of two chondrocyte-expressed isoforms of cartilage intermediate- layer protein functions as an insulin-like growth factor 1 antagonist. (PMID: 12746903) Johnson K. … Terkeltaub R. (Arthritis Rheum. 2003) 3 4 22 64
  2. Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis. (PMID: 21880736) Bernardo B.C. … Bateman J.F. (J. Biol. Chem. 2011) 3 4 64
  3. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. (PMID: 20570916) Keebler M.E. … Kathiresan S. (Circ Cardiovasc Genet 2010) 3 46 64
  4. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. (PMID: 18987386) Tai E.S. … Seielstad M. (J. Lipid Res. 2009) 3 46 64
  5. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S. … Cupples L.A. (Nat. Genet. 2009) 3 46 64

Products for CILP2 Gene

Sources for CILP2 Gene

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