Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CILP2 Gene

protein-coding GIFtS: 47
GCID: GC19P019649

cartilage intermediate layer protein 2

Explore 3 diseases affiliated with
CILP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cartilage Intermediate Layer Protein 2¹ ²
CILP-2² ³
MGC45771¹
CLIP-2²
Cartilage Intermediate Layer Protein-Like Protein 2²

External Ids:	HGNC: 24213¹	Entrez Gene: 148113²	Ensembl: ENSG00000160161⁷	OMIM: 612419⁵	UniProtKB: Q8IUL8³

Export aliases for CILP2 gene to outside databases

Previous GC identifers: GC19P019473 GC19P019511 GC19P019211

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CILP2_HUMAN, Q8IUL8

Function: May play a role in cartilage scaffolding (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CILP2 gene promoter:
HSF1 (long) CUTL1 E47 Egr-2 E2F-1 CP2 E2F HSF1short ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CILP2 promoter sequence

Search SABiosciences Chromatin IP Primers for CILP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CILP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11

CILP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CILP2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P019649: view genomic region (about GC identifiers)

Start:	19,649,057 bp from pter	End:	19,657,468 bp from pter
Size:	8,412 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CILP2_HUMAN, Q8IUL8 (See protein sequence)

Recommended Name: Cartilage intermediate layer protein 2 precursor

Size: 1156 amino acids; 126291 Da

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Secondary accessions: Q6NV88 Q8N4A6 Q8WV21

Explore the universe of human proteins at neXtProt for CILP2: NX_Q8IUL8

Post-translational modifications:

May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IUL8

CILP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_694953.2

ENSEMBL proteins:

ENSP00000291495 ENSP00000467413

Human Recombinant Protein Products for CILP2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CILP2 OriGene Custom Protein Services for CILP2
	GenScript Custom Purified and Recombinant Proteins Services for CILP2
	Novus Biologicals CILP2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CILP2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--

CILP2 for ontologies About GeneDecksing

CILP2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CILP2
	GenScript Custom Superior Antibodies Services for CILP2
	Novus Biologicals CILP2 Antibody
	Abcam antibodies for CILP2
	Uscn Antibodies for CILP2
	ThermoFisher Antibodies for CILP2

Assay Products for CILP2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CILP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CILP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CILP2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR003598 Ig_sub2

IPR000884 Thrombospondin_1_rpt

IPR013784 Carb-bd-like_fold

IPR008969 CarboxyPept-like_regulatory

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry Q8IUL8

ProtoNet protein and cluster: Q8IUL8

3 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB003599 Immunoglobulin subtype

IPB008085 Thrombospondin type 1 repeat signature

UniProtKB/Swiss-Prot: CILP2_HUMAN, Q8IUL8

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 TSP type-1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CILP2_HUMAN, Q8IUL8

Function: May play a role in cartilage scaffolding (By similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004035	NOT alkaline phosphatase activity	IDA	12746903
GO:0004180	carboxypeptidase activity	--	--
GO:0004551	NOT nucleotide diphosphatase activity	IDA	12746903
GO:0030246	carbohydrate binding	IEA	--

CILP2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CILP2:

Increased HPV18 LCR reporter a

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CILP2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CILP2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CILP2:
		hsa-miR-29c hsa-miR-29a hsa-miR-486-3p hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: CILP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CILP2 (see all 7) OriGene shRNA RFP: CILP2 OriGene siRNA: CILP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CILP2
		Sirion Biotech Custom design and validation of potent shRNA sequences against CILP2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CILP2
			Sirion Biotech Customized adenovirus for overexpression of CILP2 Sirion Biotech Customized adenovirus for potent knockdown of CILP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CILP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CILP2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CILP2 (NM_153221)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CILP2
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CILP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CILP2
		Search LifeMap BioReagents cell lines for CILP2
		Sirion Biotech Customized stable knockdown cell line services for CILP2 Sirion Biotech Customized inducible knockdown cell line services for CILP2 Sirion Biotech Customized stable overexpressing cell line services for CILP2 Sirion Biotech Customized inducible overexpressing cell line services for CILP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CILP2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CILP2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CILP2
Search CenterWatch for drugs/clinical trials and news about CILP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CILP2 gene:

NM_153221.2

Unigene Cluster for CILP2:

Cartilage intermediate layer protein 2

Hs.279574 [show with all ESTs]

Unigene Representative Sequence: AK127735

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000291495(uc002nmv.4 uc002nmw.4) ENST00000586018 ENST00000588333

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CILP2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CILP2:
		hsa-miR-29c hsa-miR-29a hsa-miR-486-3p hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: CILP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CILP2 (see all 7) OriGene shRNA RFP: CILP2 OriGene siRNA: CILP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CILP2
		Sirion Biotech Custom design and validation of potent shRNA sequences against CILP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CILP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CILP2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CILP2 (NM_153221)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CILP2
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CILP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CILP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CILP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CILP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CILP2

Additional cDNA sequence:

AF542080.1 AK127735.1 AK314213.1 BC018939.2 BC034926.1 BC068256.1

3 DOTS entries:

DT.100031141 DT.101976170 DT.97844737

24/27 AceView cDNA sequences (see all 27):

BC018939 AK127735 BC034926 BQ181405 BQ181948 BI196652 BQ182788 BG929309

BC068256 BX112879 BG928970 NM_153221 BX280777 BQ181896 AF542080 BQ181874

BQ181998 CN479743 AI073387 BF353731 BI559947 CO245313 BF313161 BF310577

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CILP2 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	^	10a	·	10b
SP1:											-						-
SP2:							-				-						-
SP3:
SP4:																											-

ECgene alternative splicing isoforms for CILP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CILP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGGGGAGGC

About this image

CILP2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

Articular chondrocyte-like cells (HyStem chondrogenic ...)

Cartilage

Micromass-induced chondrocytes (Micromass chondrogen...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)

Bone

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CILP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CILP2

SOURCE GeneReport for Unigene cluster: Hs.279574

UniProtKB/Swiss-Prot: CILP2_HUMAN, Q8IUL8

Tissue specificity: Expressed in articular chondrocytes but not in knee meniscal cartilage cells

SABiosciences Custom PCR Arrays for CILP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CILP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CILP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CILP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CILP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CILP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CILP2 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cilp2^{1 , 5}	cartilage intermediate layer protein 2^{1, 5}	77.65(n)¹ 80.16(a)¹		8 (34.01 cM)⁵ 68709¹ NM_026818.2¹ NP_081094.2¹ 69880369⁵
chicken (Gallus gallus)	Aves	CILP2¹	cartilage intermediate layer protein 2	69.94(n) 65.52(a)		430666 XM_003643398.1 XP_003643446.1
lizard (Anolis carolinensis)	Reptilia	CILP2⁶	--	63(a)	1 ↔ 1	GL344325.1(35082-43874)
zebrafish (Danio rerio)	Actinopterygii	cilp2¹	cartilage intermediate layer protein 2	56.57(n) 56.61(a)		557778 XM_680899.3 XP_685991.3

ENSEMBL Gene Tree for CILP2 (if available)
TreeFam Gene Tree for CILP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CILP2 gene

CILP²

1 SIMAP similar gene for CILP2 using alignment to 2 protein entries: CILP2_HUMAN (see all proteins):

CILP

CILP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111882230^1,2	F	--	19647173(+)	`CTCCTT/AGGCTG`	3	--	int¹ us2k¹		2		CSA	4
rs150969371^1,2		--	19647183(+)	`GAAAGC/TGGAGG`	3	--	int¹ us2k¹		0	--	--	--	--
rs28553975^1,2	C,F	--	19647205(+)	`GGTGAC/TGGAGG`	3	--	int¹ us2k¹		5		WA CSA	124
rs4808969^1,2	C,F,H	--	19647460(+)	`tccagC/Tctggg`	3	--	us2k¹ int¹		3		NA	10
rs189998208^1,2		--	19647793(+)	`GAGGGC/TGATTG`	3	--	int¹ us2k¹		0	--	--	--	--
rs202210999^1,2		--	19648089(+)	`GCCACC/TCTCCC`	3	--	int¹ us2k¹		0	--	--	--	--
rs1054930^1,2	C,F,A,H	--	19648346(+)	`CCGCGG/CCCACA`	3	--	us2k¹ ut3¹		11		MN NA WA CSA EA	554
rs191752101^1,2	C	--	19648381(+)	`AGCCCC/TCCCAC`	3	--	us2k¹ ut3¹		0	--	--	--	--
rs181258181^1,2		--	19648405(+)	`CCTCCA/GCCTCC`	3	--	us2k¹ ds500¹		0	--	--	--	--
rs184693102^1,2		--	19648519(+)	`GACTTA/CCCGCT`	3	--	ds500¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CILP2 (19649057 - 19657468 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CILP2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CILP2

DNA2.0 Custom Variant and Variant Library Synthesis for CILP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CILP2 for disorders           About GeneDecksing

OMIM gene information: 612419    OMIM disorders: --

3 diseases for CILP2:    About MalaCards

hypertriglyceridemia osteoarthritis cholesterol

Human Genome Epidemiology (HuGE) Navigator: CILP2 (6 documents)

Export disorders for CILP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CILP2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with CILP2)

Utopia: connect your pdf to the dynamic
world of online information

One of two chondrocyte-expressed isoforms of cartilage intermediate- layer protein functions as an insulin-like growth factor 1 antagonist. (PubMed id 12746903)^{1, 2, 9} Johnson K.... Terkeltaub R. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Cartilage intermediate layer protein 2 (CILP-2) is ex pressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis. (PubMed id 21880736)¹ Bernardo B.C....Bateman J.F. (2011)
Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke. (PubMed id 21691831)¹ JA!romi L....Melegh B. (2011)
Sex-specific association of rs16996148 SNP in the NCAN /CILP2/PBX4 and serum lipid levels in the Mulao and Han populations. (PubMed id 22208664)¹ Yan T.T....Pan S.L. (2011)
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)¹ Waterworth D.M....Sandhu M.S. (2010)
Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)¹ Teslovich T.M....Kathiresan S. (2010)
Pharmacogenetic analysis of lipid responses to rosuva statin in Chinese patients. (PubMed id 20679960)¹ Hu M....Tomlinson B. (2010)
Fine-mapping in African Americans of 8 recently disco vered genetic loci for plasma lipids: the Jackson Heart Study. (PubMed id 20570916)¹ Keebler M.E....Kathiresan S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 148113	HGNC: 24213	AceView: CILP2	Ensembl:ENSG00000160161	euGenes: HUgn148113
ECgene: CILP2	H-InvDB: CILP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CILP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CILP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CILP2 gene:
Search GeneIP for patents involving CILP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CILP2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CILP2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CILP2
	OriGene Protein Over-expression Lysate for CILP2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CILP2		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CILP2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CILP2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CILP2		OriGene Custom Protein Services for CILP2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CILP2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CILP2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CILP2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CILP2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CILP2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CILP2

	GenScript Custom Purified and Recombinant Proteins Services for CILP2		GenScript cDNA clones with any tag delivered in your preferred vector for CILP2
	GenScript Custom Assay Services for CILP2		GenScript Custom Superior Antibodies Services for CILP2
	GenScript Custom overexpressing Cell Line Services for CILP2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CILP2 promoter
	Search Chromatin IP Primers for CILP2
	RT² qPCR Primer Assay in human, mouse, rat CILP2
	Search GNC Networks for CILP2
	SABiosciences Custom PCR Arrays for CILP2

Search Tocris compounds for CILP2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CILP2 antibodies
	CILP2 lysates

	Antibodies for CILP2
	See all of Abcam's Antibodies, Kits and Proteins for CILP2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CILP2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CILP2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CILP2

	SwitchGear 3'UTR luciferase reporter plasmids for CILP2
	SwitchGear Promoter luciferase reporter plasmids for CILP2

ThermoFisher Antibodies for CILP2

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CILP2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CILP2

Sirion Biotech Customized:

	stable knockdown cell line services for CILP2
	inducible knockdown cell line services for CILP2
	design and validation of potent shRNA sequences against CILP2
	adenovirus for potent knockdown of CILP2
	adenovirus for overexpression of CILP2
	stable overexpressing cell line services for CILP2
	inducible overexpressing cell line services for CILP2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CILP2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CILP2 Gene

cartilage intermediate layer protein 2

Aliases
for CILP2 gene

Summaries
for CILP2 gene

Genomic Views
for CILP2 gene

Proteins
for CILP2 gene

Protein Domains /
Families
for CILP2 gene

Function
for CILP2 gene

Pathways & Interactions
for CILP2 gene

Drugs & Compounds
for CILP2 gene

Transcripts
for CILP2 gene

Expression
for CILP2 gene

Orthologs
for CILP2 gene

Paralogs
for CILP2 gene

Genomic Variants
for CILP2 gene

Disorders / Diseases
for CILP2 gene

Publications
for CILP2 gene

External Searches for CILP2 gene

Genome Databases showing CILP2 gene

Other Databases showing CILP2 gene

Specialized Databases showing CILP2 gene

Intellectual Property
for CILP2 gene

Products
for CILP2 gene

View Random Gene

Advanced Search

Export list of displayed genes

CILP2 Gene

cartilage intermediate layer protein 2

Aliasesfor CILP2 gene

Summariesfor CILP2 gene

Genomic Viewsfor CILP2 gene

Proteinsfor CILP2 gene

Protein Domains /Familiesfor CILP2 gene

Functionfor CILP2 gene

Pathways & Interactionsfor CILP2 gene

Drugs & Compoundsfor CILP2 gene

Transcriptsfor CILP2 gene

Expression for CILP2 gene

Orthologsfor CILP2 gene

Paralogsfor CILP2 gene

Genomic Variantsfor CILP2 gene

Disorders / Diseasesfor CILP2 gene

Publicationsfor CILP2 gene

External Searches for CILP2 gene

Genome Databases showing CILP2 gene

Other Databases showing CILP2 gene

Specialized Databases showing CILP2 gene

Intellectual Propertyfor CILP2 gene

Productsfor CILP2 gene

View Random Gene

Aliases
for CILP2 gene

Summaries
for CILP2 gene

Genomic Views
for CILP2 gene

Proteins
for CILP2 gene

Protein Domains /
Families
for CILP2 gene

Function
for CILP2 gene

Pathways & Interactions
for CILP2 gene

Drugs & Compounds
for CILP2 gene

Transcripts
for CILP2 gene

Expression
for CILP2 gene

Orthologs
for CILP2 gene

Paralogs
for CILP2 gene

Genomic Variants
for CILP2 gene

Disorders / Diseases
for CILP2 gene

Publications
for CILP2 gene

Intellectual Property
for CILP2 gene

Products
for CILP2 gene