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CIDEC Gene

protein-coding   GIFtS: 51
GCID: GC03M009908

Cell Death-Inducing DFFA-Like Effector C

  See CIDEC-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Death-Inducing DFFA-Like Effector C1 2     Cell Death Activator CIDE-32
FSP272 3 5     Fat Specific Protein 272
CIDE32 5     Cell Death-Inducing DFFA-Like Effector Protein C3
FPLD52 5     Fat-Specific Protein FSP27 Homolog3
CIDE-32     

External Ids:    HGNC: 242291   Entrez Gene: 639242   Ensembl: ENSG000001872887   OMIM: 6121205   UniProtKB: Q96AQ73   

Export aliases for CIDEC gene to outside databases

Previous GC identifers: GC03M009884 GC03M009844


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CIDEC Gene:
This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of
this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes
and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively
correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A
pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants
that encode different isoforms have been observed for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for CIDEC Gene:
CIDEC (cell death-inducing DFFA-like effector c) is a protein-coding gene. Diseases associated with CIDEC include lipodystrophy, familial partial, type 5. An important paralog of this gene is CIDEA.

UniProtKB/Swiss-Prot: CIDEC_HUMAN, Q96AQ7
Function: Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring
storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the
smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference
between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is
activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control
the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH.
When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by
serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to
apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the
modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its
target genes expression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CIDEC gene promoter:
         AP-1   ATF-2   MyoD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CIDEC promoter sequence
   Search Chromatin IP Primers for CIDEC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CIDEC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25

CIDEC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIDEC gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M009908:  view genomic region     (about GC identifiers)

Start:
9,908,394 bp from pter      End:
9,921,938 bp from pter
Size:
13,545 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CIDEC_HUMAN, Q96AQ7 (See protein sequence)
Recommended Name: Cell death activator CIDE-3  
Size: 238 amino acids; 26754 Da
Subunit: Homodimer (By similarity). Interacts with CEBPB. Interacts with NFAT5; this interaction is direct and
retains NFAT5 in the cytoplasm (By similarity). Interacts with CIDEA. Interacts with PLIN1
Secondary accessions: C9JMN7 Q67DW9 Q9GZY9
Alternative splicing: 4 isoforms:  Q96AQ7-1   Q96AQ7-2   Q96AQ7-3   Q96AQ7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CIDEC: NX_Q96AQ7

Explore proteomics data for CIDEC at MOPED

Post-translational modifications: 

  • Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life. Protein stability depends
    on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CIDEC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001186480.1  NP_001186481.1  NP_001186552.1  NP_071377.2  

    ENSEMBL proteins: 
     ENSP00000338642   ENSP00000392975   ENSP00000400649   ENSP00000408631   ENSP00000411356  
     ENSP00000373328  

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    antibodies-online proteins for CIDEC (7 products) 

     
    antibodies-online peptides for CIDEC

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003508 CIDE-N_dom

    Graphical View of Domain Structure for InterPro Entry Q96AQ7

    ProtoNet protein and cluster: Q96AQ7

    1 Blocks protein domain: IPB003508 Caspase-activated nuclease CIDE-N

    UniProtKB/Swiss-Prot: CIDEC_HUMAN, Q96AQ7
    Domain: The CIDE-N domain is involved in homodimerization which is crucial for its function in promoting lipid
    exchange and transfer (By similarity)
    Similarity: Contains 1 CIDE-N domain


    Find genes that share domains with CIDEC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIDEC_HUMAN, Q96AQ7
    Function: Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring
    storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the
    smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference
    between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is
    activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control
    the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH.
    When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by
    serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to
    apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the
    modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its
    target genes expression

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with CIDEC           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CIDEC:
     Increased circadian rhythm amp 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cidec):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  integument 
     liver/biliary system 

    Find genes that share phenotypes with CIDEC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CIDEC: Cidectm1Maka Cidectm1Pli

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CIDEC
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    SwitchGear 3'UTR luciferase reporter plasmidCIDEC 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CIDEC
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CIDEC_HUMAN, Q96AQ7: Nucleus (By similarity). Endoplasmic reticulum. Lipid droplet. Note=Diffuses quickly on
    lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its
    rapid enrichment at lipid droplet contact sites
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus4
    mitochondrion3
    endoplasmic reticulum2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IEA--
    GO:0005811lipid particle IBA--

    Find genes that share ontologies with CIDEC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including CIDEC: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CIDEC

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for CIDEC (Q96AQ73 ENSP000003386424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIDEAO605433I2D: score=1 
    KIAA1279Q96EK53I2D: score=1 
    --ENSP000003393444STRING: ENSP00000339344
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006915apoptotic process IDA12429024
    GO:0034389lipid particle organization IMP--
    GO:0042981regulation of apoptotic process IBA--

    Find genes that share ontologies with CIDEC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CIDEC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CIDEC gene (4 alternative transcripts): 
    NM_001199551.1  NM_001199552.1  NM_001199623.1  NM_022094.3  

    Unigene Cluster for CIDEC:

    Cell death-inducing DFFA-like effector c
    Hs.567562  [show with all ESTs]
    Unigene Representative Sequence: AF303893
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336832(uc010hcp.3 uc003btp.3 uc003btq.3 uc021wsv.1 uc021wsw.1)
    ENST00000455015(uc003btr.3) ENST00000423850(uc003bto.3 uc003bts.3)
    ENST00000430427 ENST00000443115 ENST00000487454 ENST00000383817
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CIDEC:
    hsa-miR-491-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidCIDEC 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CIDEC

    Additional mRNA sequence: 

    AF303893.1 AK024524.1 AK024530.1 AY364638.1 AY364640.1 BC016851.1 

    5 DOTS entries:

    DT.95162686  DT.75104170  DT.100788704  DT.86845992  DT.100788703 

    Selected AceView cDNA sequences (see all 43):

    AL598731 NM_022094 CD518776 CD244693 AY364640 AF303893 BQ694634 BG740660 
    CD558840 CB269236 BG696770 AY364638 AI460316 CD518729 CD517657 BV193767 
    AL598630 CD519587 BM991792 BC016851 AK024524 CD517940 AA321120 BQ695178 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CIDEC    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:                          -                                             
    SP2:                                                                        
    SP3:                    -     -                                             
    SP4:                          -                                             
    SP5:                          -     -     -                                 


    ECgene alternative splicing isoforms for CIDEC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CIDEC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATATTAGG
    CIDEC Expression
    About this image


    CIDEC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 5 entries
             Body Subcutaneous White Adipose
             White adipocyte-like cells
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
    CIDEC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CIDEC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567562

    UniProtKB/Swiss-Prot: CIDEC_HUMAN, Q96AQ7
    Tissue specificity: Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower
    levels, in brain, kidney and liver

        Pathway & Disease-focused RT2 Profiler PCR Array including CIDEC: 
              Apoptosis 384HT in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat CIDEC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIDEC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CIDEC gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cidec1 , 5 cell death-inducing DFFA-like effector c1, 5 81.65(n)1
    79.83(a)1
      6 (52.76 cM)5
    143111  NM_178373.31  NP_848460.11 
     1134246345 
    chicken
    (Gallus gallus)
    Aves CIDEC1 cell death-inducing DFFA-like effector c 66.82(n)
    63.68(a)
      100859733  NM_001277678.1  NP_001264607.1 
    lizard
    (Anolis carolinensis)
    Reptilia CIDEC6
    cell death-inducing DFFA-like effector c
    57(a)
    1 ↔ 1
    GL343417.1(29555-37782)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA987523.12   -- 75.49(n)    CA987523.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-91f15.61 si:dkey-91f15.6 58.18(n)
    53.3(a)
      564304  NM_001045047.1  NP_001038512.1 


    ENSEMBL Gene Tree for CIDEC (if available)
    TreeFam Gene Tree for CIDEC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CIDEC gene
    CIDEA2  CIDEB2  
    2 SIMAP similar genes for CIDEC using alignment to 2 protein entries:     CIDEC_HUMAN (see all proteins):
    CIDEA    CIDEB

    Find genes that share paralogs with CIDEC           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CIDEC
    PGOHUM00000240016 PGOHUM00000237528 PGOHUM00000238176


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CIDEC (see all 368)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446162261,2
    --9907975(+) TTAGAA/GGAGTG 4 -- ds50010--------
    rs1466512671,2
    --9907995(+) CACCTC/GCTCAA 4 -- ds50010--------
    rs1845981171,2
    C--9908174(+) CTCCTC/GGTCTC 4 -- ds50010--------
    rs1489057341,2
    C--9908241(+) GTGCCC/TAGCTG 4 -- ds50010--------
    rs1136071371,2
    C--9908247(+) AGCTG-/TTTTTT 4 -- ds50011Minor allele frequency- T:0.00CSA 2
    rs738115971,2
    C,F--9908284(+) CATTAG/CCTGTA 4 -- ds50011Minor allele frequency- C:0.50WA 2
    rs1480469251,2
    --9908294(+) AATCCC/TACATT 4 -- ds50010--------
    rs1895127111,2
    --9908306(+) AAGAGA/CATACT 4 -- ds50010--------
    rs1811494661,2
    --9908326(+) GATTCA/GTCTCT 4 -- ds50010--------
    rs1417250461,2
    --9908352(+) CAACCC/TTCCAG 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for CIDEC (9908394 - 9921938 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CIDEC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724890CNV Deletion23290073
    esv2666111CNV Deletion23128226
    nsv821983CNV Loss20364138
    nsv834615CNV Loss17160897

    Human Gene Mutation Database (HGMD): CIDEC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CIDEC
    DNA2.0 Custom Variant and Variant Library Synthesis for CIDEC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 612120   
    OMIM disorders: 615238  
    UniProtKB/Swiss-Prot: CIDEC_HUMAN, Q96AQ7
  • Note=In omental adipose tissue of obese patients matched for BMI, expression levels tend to correlate
    with insulin sensitivity. Expression is increased 2-3 fold in the group of patients with high insulin
    sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that
    triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away
    from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. This effect
    is not significant in subcutaneous adipose tissue (PubMed:18509062). In subcutaneous adipose tissue of diabetic
    patients, tends to negatively correlate with body mass index and total fat mass, independently of insulin
    sensitivity (PubMed:18334488)
  • Lipodystrophy, familial partial, 5 (FPLD5) [MIM:615238]: A form of lipodystrophy characterized by loss of
    subcutaneous adipose tissue affecting limb, femorogluteal and subcutaneous abdominal fat, preservation of
    visceral, neck and axilliary fat, hepatomegaly, hepatic steatosis and insulin-resistant diabetes. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 1 disease for CIDEC:    
    About MalaCards
    lipodystrophy, familial partial, type 5


    Find genes that share disorders with CIDEC           About GenesLikeMe


    Export disorders for CIDEC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CIDEC gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with CIDEC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family. (PubMed id 12429024)1, 2, 3, 9 Liang L.... Li T. (Biochem. J. 2003)
    2. Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA. (PubMed id 19843876)1, 2, 9 Liu K....Smas C.M. (Am. J. Physiol. 2009)
    3. Fat-specific protein 27 regulates storage of triacylglycerol. (PubMed id 18334488)1, 2, 9 Keller P....MacDougald O.A. (J. Biol. Chem. 2008)
    4. Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. (PubMed id 20049731)1, 2 Rubio-Cabezas O....Savage D.B. (EMBO Mol Med 2009)
    5. Cidea is associated with lipid droplets and insulin sensitivity in humans. (PubMed id 18509062)1, 2 Puri V....Czech M.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss. (PubMed id 19661960)1, 9 Hall A.M....Finck B.N. (Obesity (Silver Spring) 2010)
    9. Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress. (PubMed id 23233732)1 Ueno M....Kraemer F.B. (J. Lipid Res. 2013)
    10. FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes. (PubMed id 23399566)2 Grahn T.H.... Puri V. (Biochem. Biophys. Res. Commun. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 63924 HGNC: 24229 AceView: CIDEC Ensembl:ENSG00000187288 euGenes: HUgn63924
    ECgene: CIDEC H-InvDB: CIDEC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CIDEC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CIDEC gene:
    Search GeneIP for patents involving CIDEC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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