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CIDEA Gene

protein-coding   GIFtS: 61
GCID: GC18P012254

Cell Death-Inducing DFFA-Like Effector A

  See CIDEA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Death-Inducing DFFA-Like Effector A1 2 3
CIDE-A2
Cell Death Activator CIDE-A2

External Ids:    HGNC: 19761   Entrez Gene: 11492   Ensembl: ENSG000001761947   OMIM: 6044405   UniProtKB: O605433   

Export aliases for CIDEA gene to outside databases

Previous GC identifers: GC00U990051 GC18P012311 GC18P012244 GC18P012208


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CIDEA Gene:
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This
activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice
that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core
body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes.
This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced
transcripts have been identified. (provided by RefSeq, Aug 2010)

GeneCards Summary for CIDEA Gene:
CIDEA (cell death-inducing DFFA-like effector a) is a protein-coding gene. Diseases associated with CIDEA include obesity. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CIDEC.

UniProtKB/Swiss-Prot: CIDEA_HUMAN, O60543
Function: Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB
downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB,
strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1
from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting
lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral
lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal
pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by
CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear

Gene Wiki entry for CIDEA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010859.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CIDEA gene promoter:
         PPAR-gamma1   AP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CIDEA promoter sequence
   Search Chromatin IP Primers for CIDEA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CIDEA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.21|18   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.21

CIDEA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIDEA gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P012254:  view genomic region     (about GC identifiers)

Start:
12,254,318 bp from pter      End:
12,277,594 bp from pter
Size:
23,277 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CIDEA_HUMAN, O60543 (See protein sequence)
Recommended Name: Cell death activator CIDE-A  
Size: 219 amino acids; 24687 Da
Subunit: Directly interacts with CEBPB (By similarity). Interacts with CIDEC
1 PDB 3D structure from and Proteopedia for CIDEA:
2EEL (3D)    
Secondary accessions: B0YIY7 Q6UPR7

Explore the universe of human proteins at neXtProt for CIDEA: NX_O60543

Explore proteomics data for CIDEA at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CIDEA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001270.1  
    ENSEMBL proteins: 
     ENSP00000320209   ENSP00000429238  

    CIDEA Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CIDEA
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    Novus Biologicals CIDEA Proteins
    Novus Biologicals CIDEA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CIDEA

     
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    Cloud-Clone Corp. ELISAs for CIDEA
    Cloud-Clone Corp. CLIAs for CIDEA
    Search eBioscience for ELISAs for CIDEA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003508 CIDE-N_dom

    Graphical View of Domain Structure for InterPro Entry O60543

    ProtoNet protein and cluster: O60543

    1 Blocks protein domain: IPB003508 Caspase-activated nuclease CIDE-N

    UniProtKB/Swiss-Prot: CIDEA_HUMAN, O60543
    Similarity: Contains 1 CIDE-N domain


    Find genes that share domains with CIDEA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIDEA_HUMAN, O60543
    Function: Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB
    downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB,
    strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1
    from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting
    lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral
    lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal
    pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by
    CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity ISS17080483
         
    Find genes that share ontologies with CIDEA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CIDEA:
     Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cidea):
     adipose tissue  homeostasis/metabolism 

    Find genes that share phenotypes with CIDEA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cideatm1Pli for CIDEA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CIDEA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CIDEA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIDEA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIDEA

    miRNA
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    miRTarBase miRNAs that target CIDEA:
    hsa-mir-148b-3p (MIRT019409)

    Block miRNA regulation of human, mouse, rat CIDEA using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CIDEA
    SwitchGear 3'UTR luciferase reporter plasmidCIDEA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CIDEA

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    GenScript: all cDNA clones in your preferred vector: CIDEA (NM_001279)
    Sino Biological Human cDNA Clone for CIDEA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIDEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIDEA

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIDEA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CIDEA_HUMAN, O60543: Lipid droplet. Nucleus (By similarity). Note=Enriched at lipid droplet contact sites. Has
    been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling
    activity (By similarity). These data could not be confirmed (PubMed:18509062)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS17080483
    GO:0005737cytoplasm ISS17080483
    GO:0005739mitochondrion ISS--
    GO:0005740mitochondrial envelope ISS--

    Find genes that share ontologies with CIDEA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CIDEA About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of Oct 3 4
    Selected targets of Oct 3 4




        Pathway & Disease-focused RT2 Profiler PCR Arrays including CIDEA: 
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CIDEA

    Selected Interacting proteins for CIDEA (O605432, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR1H2P550552, 3MINT-8089887 MINT-8089900 I2D: score=1 
    ZBTB16Q055163I2D: score=3 
    CIDEBQ9UHD43I2D: score=1 
    CIDECQ96AQ73I2D: score=1 
    CYB5R4Q7L1T63I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis ISS--
    GO:0006309apoptotic DNA fragmentation IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006629lipid metabolic process ISS--

    Find genes that share ontologies with CIDEA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CIDEA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CIDEA gene: 
    NM_001279.3  

    Unigene Cluster for CIDEA:

    Cell death-inducing DFFA-like effector a
    Hs.249129  [show with all ESTs]
    Unigene Representative Sequence: AK122762
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320477 ENST00000522713(uc002kqt.4 uc002kqu.4 uc010dlc.3)
    ENST00000521296 ENST00000520620
    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CIDEA (NM_001279)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIDEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIDEA
    Primer
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    OriGene qPCR primer pairs and template standards for CIDEA
    OriGene qSTAR qPCR primer pairs in human, mouse for CIDEA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CIDEA
      QuantiTect SYBR Green Assays in human, mouse, rat CIDEA
      QuantiFast Probe-based Assays in human, mouse, rat CIDEA

    Additional mRNA sequence: 

    AF041378.1 AK122762.1 AY364639.1 BC031896.1 NR_036468.1 

    3 DOTS entries:

    DT.100021513  DT.40294580  DT.101981370 

    Selected AceView cDNA sequences (see all 38):

    BC031896 BQ718688 NM_198289 AF041378 BG742691 NM_001279 BG743378 AI910369 
    CB266587 BG739825 BG698447 BG740286 CA406654 BX096387 BG698059 AY364639 
    CB266645 BG675427 AK122762 CA407314 BG697827 BG697458 BG696844 BG743161 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CIDEA    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                                                                  
    SP2:        -     -           -                                       
    SP3:                          -                                       
    SP4:                          -           -                           


    ECgene alternative splicing isoforms for CIDEA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CIDEA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCAGAGCC
    CIDEA Expression
    About this image


    CIDEA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 5 entries
             Thoracic Perivascular Adipose
             Brown adipocyte-like cells
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    CIDEA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CIDEA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249129

    UniProtKB/Swiss-Prot: CIDEA_HUMAN, O60543
    Tissue specificity: Expressed in omental and subcutaneous adipose tissue (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CIDEA: 
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CIDEA
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    QuantiFast Probe-based Assays in human, mouse, rat CIDEA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIDEA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CIDEA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cidea1 , 5 cell death-inducing DNA fragmentation factor, alpha more1, 5 82.41(n)1
    83.8(a)1
      18 (39.94 cM)5
    126831  NM_007702.21  NP_031728.21 
     673435645 
    chicken
    (Gallus gallus)
    Aves CIDEA1 cell death-inducing DFFA-like effector a 66.04(n)
    60.56(a)
      768659  NM_001195123.1  NP_001182052.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia CA985628.12   -- 74.53(n)    CA985628.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF594479.12   -- 76.45(n)   325866  CF594479.1 


    ENSEMBL Gene Tree for CIDEA (if available)
    TreeFam Gene Tree for CIDEA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CIDEA gene
    CIDEC2  CIDEB2  
    2 SIMAP similar genes for CIDEA using alignment to 3 protein entries:     CIDEA_HUMAN (see all proteins):
    CIDEC    CIDEB

    Find genes that share paralogs with CIDEA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CIDEA (see all 805)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815358751,2
    C--12252372(+) GTCCCC/TACCCC 2 -- us2k10--------
    rs1853347711,2
    --12252490(+) AAGCTA/GAAGGA 2 -- us2k10--------
    rs1181673101,2
    C,F--12252515(+) GTTCAA/TATTCA 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs455377391,2
    C--12252525(+) AAATAT/CAAAGA 2 -- us2k13Minor allele frequency- C:0.05NS NA 162
    rs454860971,2
    C,F--12252532(+) AAGAAC/AAAAGA 2 -- us2k14Minor allele frequency- A:0.05NS NA 164
    rs1891595051,2
    --12252563(+) GTGGTA/TGAATC 2 -- us2k10--------
    rs1818866651,2
    --12252573(+) CCAGGC/GGCTGG 2 -- us2k10--------
    rs679235231,2
    C--12252610(+) CTCTT-/TATC  
            
    ATCTA
    2 -- us2k10--------
    rs1414122891,2
    C--12252610(+) TCTCT-/TATCT 
     ATCTATC
    TATCT
    2 -- us2k10--------
    rs456205321,2
    C,F--12252643(+) TATCT-/ATCTATCTATCT/
    ATCTATCTATCTATCT
    TATAT
    1 -- us2k11NS 40

    HapMap Linkage Disequilibrium report for CIDEA (12254318 - 12277594 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CIDEA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909400CNV Loss21882294
    dgv3387n71CNV Loss21882294
    nsv909401CNV Gain21882294
    dgv1012e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CIDEA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CIDEA
    DNA2.0 Custom Variant and Variant Library Synthesis for CIDEA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604440    OMIM disorders: --

    UniProtKB/Swiss-Prot: CIDEA_HUMAN, O60543
  • Note=In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels
    correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin
    sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that
    triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away
    from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle

  • 1 disease for CIDEA:    
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    obesity


    Find genes that share disorders with CIDEA           About GenesLikeMe

    3 Novoseek inferred disease relationships for CIDEA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 31.3 11 15919794 (4), 16186410 (4), 19661960 (1), 18607384 (1)
    necrosis 13.1 1 18607384 (1)
    tumors 0 2 16230407 (1), 18607384 (1)

    Genetic Association Database (GAD): CIDEA
    Human Genome Epidemiology (HuGE) Navigator: CIDEA (3 documents)

    Export disorders for CIDEA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CIDEA gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CIDEA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cidea is associated with lipid droplets and insulin sensitivity in humans. (PubMed id 18509062)1, 2, 3 Puri V....Czech M.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    2. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. (PubMed id 9564035)1, 2, 3 Inohara N.... Nunez G. (EMBO J. 1998)
    3. The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. (PubMed id 16186410)1, 4, 9 Dahlman I....Arner P. (Diabetes 2005)
    4. Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G--&gt;T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men. (PubMed id 18328351)1, 4 Zhang L....Muramatsu M. (Metab. Clin. Exp. 2008)
    5. A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. (PubMed id 15919794)1, 9 NordstrAPm E.A....Arner P. (Diabetes 2005)
    6. Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis. (PubMed id 17080483)1, 9 Iwahana H....Souchelnytskyi S. (Proteomics 2006)
    7. Expression of CIDE proteins in clear cell renal cell carcinoma and their prognostic significance. (PubMed id 23475172)1 Yu M....Ye J. (Mol. Cell. Biochem. 2013)
    8. Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population. (PubMed id 21106268)1 Zhang L....Hua Q. (Diabetes Res. Clin. Pract. 2011)
    9. Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes. (PubMed id 21636835)1 Ito M....Murakami K. (J. Lipid Res. 2011)
    10. CIDEA interacts with liver X receptors in white fat cells. (PubMed id 21315073)1 KulytAc A....Laurencikiene J. (FEBS Lett. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1149 HGNC: 1976 AceView: CIDEA Ensembl:ENSG00000176194 euGenes: HUgn1149
    ECgene: CIDEA H-InvDB: CIDEA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CIDEA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CIDEA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CIDEA gene:
    Search GeneIP for patents involving CIDEA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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