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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CIDEA Gene

protein-coding   GIFtS: 62
GCID: GC18P012254

Cell Death-Inducing DFFA-Like Effector A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cell Death-Inducing DFFA-Like Effector A1 2 3
CIDE-A2
Cell Death Activator CIDE-A2

External Ids:    HGNC: 19761   Entrez Gene: 11492   Ensembl: ENSG000001761947   OMIM: 6044405   UniProtKB: O605433   
ORGUL members:         
NONCODE14:n410031      

Export aliases for CIDEA gene to outside databases

Previous GC identifers: GC00U990051 GC18P012311 GC18P012244 GC18P012208


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CIDEA Gene:
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This
activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice
that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core
body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes.
This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced
transcripts have been identified. (provided by RefSeq, Aug 2010)

GeneCards Summary for CIDEA Gene: 
CIDEA (cell death-inducing DFFA-like effector a) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CIDEA include obesity, and chronic myeloid leukemia. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CIDEC.

UniProtKB/Swiss-Prot: CIDEA_HUMAN, O60543
Function: Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB
downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB,
strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1
from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting
lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral
lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal
pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by
CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear

Gene Wiki entry for CIDEA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.2  NT_010859.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CIDEA gene promoter:
         PPAR-gamma1   AP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CIDEA promoter sequence
   Search SABiosciences Chromatin IP Primers for CIDEA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIDEA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.21|18   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.21

CIDEA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIDEA gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P012254:  view genomic region     (about GC identifiers)

Start:
12,254,318 bp from pter      End:
12,277,594 bp from pter
Size:
23,277 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CIDEA_HUMAN, O60543 (See protein sequence)
Recommended Name: Cell death activator CIDE-A  
Size: 219 amino acids; 24687 Da
Subunit: Directly interacts with CEBPB (By similarity). Interacts with CIDEC
Subcellular location: Lipid droplet. Nucleus (By similarity). Note=Enriched at lipid droplet contact sites. Has
been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling
activity (By similarity). These data could not be confirmed (PubMed:18509062)
1 PDB 3D structure from and Proteopedia for CIDEA:
2EEL (3D)    
Secondary accessions: B0YIY7 Q6UPR7

Explore the universe of human proteins at neXtProt for CIDEA: NX_O60543

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60543

  • CIDEA Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001270.1  
    ENSEMBL proteins: 
     ENSP00000320209   ENSP00000429238  

    Human Recombinant Protein Products for CIDEA: 
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    Novus Biologicals CIDEA Proteins
    Novus Biologicals CIDEA Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CIDEA 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS17080483
    GO:0005737cytoplasm ISS17080483
    GO:0005739mitochondrion ISS--
    GO:0005740mitochondrial envelope ISS--

    CIDEA for ontologies           About GeneDecksing



    CIDEA Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003508 CAD

    Graphical View of Domain Structure for InterPro Entry O60543

    ProtoNet protein and cluster: O60543

    1 Blocks protein domain: IPB003508 Caspase-activated nuclease CIDE-N

    UniProtKB/Swiss-Prot: CIDEA_HUMAN, O60543
    Similarity: Contains 1 CIDE-N domain


    CIDEA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIDEA_HUMAN, O60543
    Function: Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB
    downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB,
    strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1
    from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting
    lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral
    lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal
    pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by
    CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity ISS17080483
         
    CIDEA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CIDEA:
     Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cidea):
     adipose tissue  homeostasis/metabolism 

    CIDEA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cideatm1Pli for CIDEA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CIDEA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CIDEA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIDEA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIDEA 

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    SwitchGear 3'UTR luciferase reporter plasmidCIDEA 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIDEA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CIDEA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of Oct-3/4
    Selected targets of Oct-3/4

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CIDEA
        Selected targets of Oct-3/4





    CIDEA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CIDEA

    5/10 Interacting proteins for CIDEA (O605432, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR1H2P550552, 3MINT-8089887 MINT-8089900 I2D: score=1 
    ZBTB16Q055163I2D: score=3 
    CIDEBQ9UHD43I2D: score=1 
    CIDECQ96AQ73I2D: score=1 
    CYB5R4Q7L1T63I2D: score=1 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis ISS--
    GO:0006309apoptotic DNA fragmentation ISS9564035
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006629lipid metabolic process ISS--

    CIDEA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CIDEA

    Search CenterWatch for drugs/clinical trials and news about CIDEA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CIDEA gene: 
    NM_001279.3  

    Unigene Cluster for CIDEA:

    Cell death-inducing DFFA-like effector a
    Hs.249129  [show with all ESTs]
    Unigene Representative Sequence: AK122762
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320477 ENST00000522713(uc002kqt.4 uc002kqu.4 uc010dlc.3)
    ENST00000521296 ENST00000520620
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CIDEA
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CIDEA
    SwitchGear 3'UTR luciferase reporter plasmidCIDEA 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIDEA
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                         Customized lentivirus expression plasmids for stable overexpression of CIDEA 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIDEA

    Additional mRNA sequence: 

    AF041378.1 AK122762.1 AY364639.1 BC031896.1 NR_036468.1 

    3 DOTS entries:

    DT.100021513  DT.40294580  DT.101981370 

    24/38 AceView cDNA sequences (see all 38):

    BG743378 BQ718688 BC031896 AI910369 NM_198289 AF041378 BG742691 NM_001279 
    BG695887 BG740286 BG743161 AY364639 BG697827 BG674879 BX096387 BG675427 
    CB266587 BG696844 AK122762 BG739825 BQ694651 BG697458 BQ694981 BG698447 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CIDEA    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                                                                  
    SP2:        -     -           -                                       
    SP3:                          -                                       
    SP4:                          -           -                           


    ECgene alternative splicing isoforms for CIDEA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CIDEA expression in normal human tissues (normalized intensities)      CIDEA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCAGAGCC
    CIDEA Expression
    About this image


    CIDEA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 5 entries
             Thoracic Perivascular Adipose
             Brown adipocyte-like cells ( Directed differentiation of human pluripotent stem cells...
             omental adipose tissue   
     
     Choroid Plexus (Uncategorized)    fully expand to see all 2 entries
             Human Choroid Plexus Fibroblasts (HCPF)   
     
     Blood Brain Barrier (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod

    Genevestigator expression for CIDEA

    SOURCE GeneReport for Unigene cluster: Hs.249129

    UniProtKB/Swiss-Prot: CIDEA_HUMAN, O60543
    Tissue specificity: Expressed in omental and subcutaneous adipose tissue (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including CIDEA: 
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIDEA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CIDEA gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cidea1 , 5 cell death-inducing DNA fragmentation factor, alpha more1, 5 82.41(n)1
    83.8(a)1
      18 (39.94 cM)5
    126831  NM_007702.21  NP_031728.21 
     673435645 
    chicken
    (Gallus gallus)
    Aves CIDEA1 cell death-inducing DFFA-like effector a 66.04(n)
    60.56(a)
      768659  NM_001195123.1  NP_001182052.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia CA985628.12   -- 74.53(n)    CA985628.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF594479.12   -- 76.45(n)   325866  CF594479.1 


    ENSEMBL Gene Tree for CIDEA (if available)
    TreeFam Gene Tree for CIDEA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CIDEA gene
    CIDEC2  CIDEB2  
    2 SIMAP similar genes for CIDEA using alignment to 3 protein entries:     CIDEA_HUMAN (see all proteins):
    CIDEC    CIDEB

    CIDEA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/805 SNPs in CIDEA are shown (see all 805)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0487384
    ----see VAR_0487382 V F mis40--------
    rs1815358751,2
    C--12252372(+) GTCCCC/TACCCC 2 -- us2k10--------
    rs1853347711,2
    --12252490(+) AAGCTA/GAAGGA 2 -- us2k10--------
    rs1181673101,2
    C,F--12252515(+) GTTCAA/TATTCA 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs455377391,2
    C--12252525(+) AAATAT/CAAAGA 2 -- us2k13Minor allele frequency- C:0.05NS NA 162
    rs454860971,2
    C,F--12252532(+) AAGAAC/AAAAGA 2 -- us2k14Minor allele frequency- A:0.05NS NA 164
    rs1891595051,2
    --12252563(+) GTGGTA/TGAATC 2 -- us2k10--------
    rs1818866651,2
    --12252573(+) CCAGGC/GGCTGG 2 -- us2k10--------
    rs679235231,2
    C--12252610(+) CTCTT-/TATC  
            
    ATCTA
    2 -- us2k10--------
    rs1414122891,2
    C--12252610(+) TCTCT-/TATCT 
     ATCTATC
    TATCT
    2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CIDEA (12254318 - 12277594 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CIDEA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv909400CNV Loss21882294
    dgv3387n71CNV Loss21882294
    nsv909401CNV Gain21882294
    dgv1012e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): CIDEA
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604440    OMIM disorders: --

    UniProtKB/Swiss-Prot: CIDEA_HUMAN, O60543
  • Note=In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels
    correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin
    sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that
    triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away
    from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle

  • 10 diseases for CIDEA:    About MalaCards
    obesity    chronic myeloid leukemia    retinal degeneration    endometrial carcinoma
    retinitis    myeloid leukemia    insulin resistance    leukemia
    hepatitis    neuronitis


    CIDEA for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for CIDEA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 31.3 11 15919794 (4), 16186410 (4), 19661960 (1), 18607384 (1)
    necrosis 13.1 1 18607384 (1)
    tumors 0 2 16230407 (1), 18607384 (1)

    Genetic Association Database (GAD): CIDEA
    Human Genome Epidemiology (HuGE) Navigator: CIDEA (3 documents)

    Export disorders for CIDEA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CIDEA gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with CIDEA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cidea is associated with lipid droplets and insulin sensitivity in humans. (PubMed id 18509062)1, 2, 3 Puri V....Czech M.P. (2008)
    2. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. (PubMed id 9564035)1, 2, 3 Inohara N.... Nunez G. (1998)
    3. The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. (PubMed id 16186410)1, 4, 9 Dahlman I....Arner P. (2005)
    4. Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men. (PubMed id 18328351)1, 4 Zhang L....Muramatsu M. (2008)
    5. A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. (PubMed id 15919794)1, 9 Nordstrom E.A....Arner P. (2005)
    6. Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis. (PubMed id 17080483)1, 9 Iwahana H....Souchelnytskyi S. (2006)
    7. Association of the cell death-inducing DNA fragmentat ion factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phe notypes of metabolic syndrome in a Chinese population. (PubMed id 21106268)1 Zhang L....Hua Q. (2011)
    8. Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes. (PubMed id 21636835)1 Ito M....Murakami K. (2011)
    9. CIDEA interacts with liver X receptors in white fat c ells. (PubMed id 21315073)1 KulytAc A....Laurencikiene J. (2011)
    10. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1149 HGNC: 1976 AceView: CIDEA Ensembl:ENSG00000176194 euGenes: HUgn1149
    ECgene: CIDEA H-InvDB: CIDEA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CIDEA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CIDEA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CIDEA gene:
    Search GeneIP for patents involving CIDEA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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