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Aliases for CIDEA Gene

Aliases for CIDEA Gene

  • Cell Death-Inducing DFFA-Like Effector A 2 3 4
  • Cell Death Activator CIDE-A 3
  • CIDE-A 3

External Ids for CIDEA Gene

Summaries for CIDEA Gene

Entrez Gene Summary for CIDEA Gene

  • This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]

GeneCards Summary for CIDEA Gene

CIDEA (Cell Death-Inducing DFFA-Like Effector A) is a Protein Coding gene. Diseases associated with CIDEA include obesity. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CIDEB.

UniProtKB/Swiss-Prot for CIDEA Gene

  • Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.

Gene Wiki entry for CIDEA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIDEA Gene

Genomics for CIDEA Gene

Genomic Location for CIDEA Gene

Start:
12,254,319 bp from pter
End:
12,277,595 bp from pter
Size:
23,277 bases
Orientation:
Plus strand

Genomic View for CIDEA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIDEA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIDEA Gene

Regulatory Elements for CIDEA Gene

Proteins for CIDEA Gene

  • Protein details for CIDEA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60543-CIDEA_HUMAN
    Recommended name:
    Cell death activator CIDE-A
    Protein Accession:
    O60543
    Secondary Accessions:
    • B0YIY7
    • Q6UPR7

    Protein attributes for CIDEA Gene

    Size:
    219 amino acids
    Molecular mass:
    24687 Da
    Quaternary structure:
    • Directly interacts with CEBPB (By similarity). Interacts with CIDEC.

    Three dimensional structures from OCA and Proteopedia for CIDEA Gene

neXtProt entry for CIDEA Gene

Proteomics data for CIDEA Gene at MOPED

Post-translational modifications for CIDEA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIDEA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CIDEA Gene

Domains for CIDEA Gene

Protein Domains for CIDEA Gene

UniProtKB/Swiss-Prot:

CIDEA_HUMAN
Domain:
  • Contains 1 CIDE-N domain.:
    • O60543
genes like me logo Genes that share domains with CIDEA: view

No data available for Gene Families for CIDEA Gene

Function for CIDEA Gene

Molecular function for CIDEA Gene

UniProtKB/Swiss-Prot Function: Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.

Gene Ontology (GO) - Molecular Function for CIDEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity ISS 17080483
genes like me logo Genes that share ontologies with CIDEA: view

Phenotypes for CIDEA Gene

genes like me logo Genes that share phenotypes with CIDEA: view

Animal Models for CIDEA Gene

MGI Knock Outs for CIDEA:

miRNA for CIDEA Gene

miRTarBase miRNAs that target CIDEA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CIDEA Gene

Localization for CIDEA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIDEA Gene

Lipid droplet. Nucleus. Note=Enriched at lipid droplet contact sites. Has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062). {ECO:0000250, ECO:0000269 PubMed:18509062}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIDEA Gene COMPARTMENTS Subcellular localization image for CIDEA gene
Compartment Confidence
cytosol 3
mitochondrion 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CIDEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus ISS 17080483
GO:0005737 cytoplasm ISS 17080483
GO:0005739 mitochondrion ISS --
GO:0005740 mitochondrial envelope ISS --
genes like me logo Genes that share ontologies with CIDEA: view

Pathways for CIDEA Gene

SuperPathways for CIDEA Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIDEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006629 lipid metabolic process ISS --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with CIDEA: view

No data available for Pathways by source for CIDEA Gene

Transcripts for CIDEA Gene

Unigene Clusters for CIDEA Gene

Cell death-inducing DFFA-like effector a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CIDEA Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1:
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for CIDEA Gene

GeneLoc Exon Structure for
CIDEA
ECgene alternative splicing isoforms for
CIDEA

Expression for CIDEA Gene

mRNA expression in normal human tissues for CIDEA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CIDEA Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (19.2), Adipose - Subcutaneous (12.6), and Breast - Mammary Tissue (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CIDEA Gene

SOURCE GeneReport for Unigene cluster for CIDEA Gene Hs.249129

mRNA Expression by UniProt/SwissProt for CIDEA Gene

O60543-CIDEA_HUMAN
Tissue specificity: Expressed in omental and subcutaneous adipose tissue (at protein level).
genes like me logo Genes that share expressions with CIDEA: view

Orthologs for CIDEA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIDEA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIDEA 36
  • 99.09 (n)
  • 99.09 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 87 (a)
OneToMany
CIDEA 36
  • 80.65 (n)
  • 80.49 (a)
CIDEA 37
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CIDEA 36
  • 82.11 (n)
  • 77.98 (a)
CIDEA 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cidea 36
  • 82.41 (n)
  • 83.8 (a)
Cidea 16
Cidea 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CIDEA 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 77 (a)
OneToMany
-- 37
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cidea 36
  • 81.62 (n)
  • 83.18 (a)
chicken
(Gallus gallus)
Aves CIDEA 36
  • 66.04 (n)
  • 60.56 (a)
CIDEA 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cidea 36
  • 60.51 (n)
  • 56.87 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
cidea 36
  • 60.36 (n)
  • 52.66 (a)
cidea 37
  • 43 (a)
OneToOne
Species with no ortholog for CIDEA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIDEA Gene

ENSEMBL:
Gene Tree for CIDEA (if available)
TreeFam:
Gene Tree for CIDEA (if available)

Paralogs for CIDEA Gene

Paralogs for CIDEA Gene

Selected SIMAP similar genes for CIDEA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CIDEA: view

Variants for CIDEA Gene

Sequence variations from dbSNP and Humsavar for CIDEA Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1800611 -- 12,258,657(-) CAGCG(C/G)TGCGG intron-variant
rs1800612 -- 12,258,586(-) GAGCC(C/T)CTCTT intron-variant
rs4074432 -- 12,275,996(+) TTCTT(A/C/T)TTTTT intron-variant
rs4077043 -- 12,277,996(-) CCAGC(C/T)TGGGT downstream-variant-500B
rs4796955 -- 12,262,403(+) TTGTG(G/T)AAACA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CIDEA Gene

Variant ID Type Subtype PubMed ID
nsv909400 CNV Loss 21882294
nsv909401 CNV Gain 21882294
dgv3387n71 CNV Loss 21882294
dgv1012e1 CNV Complex 17122850

Relevant External Links for CIDEA Gene

HapMap Linkage Disequilibrium report
CIDEA
Human Gene Mutation Database (HGMD)
CIDEA

Disorders for CIDEA Gene

UniProtKB/Swiss-Prot

CIDEA_HUMAN
  • Note=In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. {ECO:0000269 PubMed:18509062}.

(1) MalaCards Diseases for CIDEA Gene

Search for CIDEA Gene in MalaCards »

(3) Novoseek inferred disease relationships for CIDEA Gene

Disease -log(P) Hits PubMed IDs
obesity 31.3 10
necrosis 13.1 1
tumors 0 2

Relevant External Links for CIDEA

Genetic Association Database (GAD)
CIDEA
Human Genome Epidemiology (HuGE) Navigator
CIDEA
genes like me logo Genes that share disorders with CIDEA: view

Publications for CIDEA Gene

  1. The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. (PMID: 16186410) Dahlman I. … Arner P. (Diabetes 2005) 3 23 49
  2. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. (PMID: 9564035) Inohara N. … Nunez G. (EMBO J. 1998) 2 3 4
  3. Cidea is associated with lipid droplets and insulin sensitivity in humans. (PMID: 18509062) Puri V. … Czech M.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 4
  4. Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis. (PMID: 17080483) Iwahana H. … Souchelnytskyi S. (Proteomics 2006) 3 23
  5. Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men. (PMID: 18328351) Zhang L. … Muramatsu M. (Metab. Clin. Exp. 2008) 3 49

Products for CIDEA Gene

Sources for CIDEA Gene

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