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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CIC Gene

protein-coding   GIFtS: 60
GCID: GC19P042772

Capicua Transcriptional Repressor

(Previous names: capicua (Drosophila) homolog, capicua homolog (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Capicua Transcriptional Repressor1 2
KIAA03063 5
Capicua (Drosophila) Homolog1
Capicua Homolog (Drosophila)1
Capicua Homolog2
Protein Capicua Homolog2

External Ids:    HGNC: 142141   Entrez Gene: 231522   Ensembl: ENSG000000794327   OMIM: 6120825   UniProtKB: Q96RK03   

Export aliases for CIC gene to outside databases

Previous GC identifers: GC19P043435 GC19P043180 GC19P047454 GC19P047480 GC19P042788 GC19P039219


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CIC Gene: 
CIC (capicua transcriptional repressor) is a protein-coding gene. Diseases associated with CIC include pityriasis versicolor, and oligodendroglioma. GO annotations related to this gene include protein binding and DNA binding. An important paralog of this gene is BBX.

UniProtKB/Swiss-Prot: CIC_HUMAN, Q96RK0
Function: Transcriptional repressor which may play a role in development of the central nervous system (CNS)

Gene Wiki entry for CIC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CIC gene promoter:
         CREB   TBP   AREB6   deltaCREB   c-Myb   Ik-3   Roaz   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CIC promoter sequence
   Search SABiosciences Chromatin IP Primers for CIC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042772:  view genomic region     (about GC identifiers)

Start:
42,772,689 bp from pter      End:
42,799,949 bp from pter
Size:
27,261 bases      Orientation:
plus strand

1 alternative location:
Chr7-,CRA_TCAG 62,567,254-62,569,083     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CIC_HUMAN, Q96RK0 (See protein sequence)
Recommended Name: Protein capicua homolog  
Size: 1608 amino acids; 163820 Da
Subunit: Interacts with ATXN1 and ATXN1L (By similarity)
Subcellular location: Nucleus (Potential)
Miscellaneous: Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage
Sequence caution: Sequence=AAD11988.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for CIC:
4J2J (3D)        4J2L (3D)    
Secondary accessions: Q7LGI1 Q9UEG5 Q9Y6T1

Explore the universe of human proteins at neXtProt for CIC: NX_Q96RK0

Explore proteomics data for CIC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96RK0

  • CIC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CIC Protein Expression
    REFSEQ proteins: NP_055940.3  
    ENSEMBL proteins: 
     ENSP00000459719   ENSP00000459704   ENSP00000160740   ENSP00000458663   ENSP00000458543  
     ENSP00000459011   ENSP00000460230  

    Human Recombinant Protein Products for CIC: 
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    OriGene Custom Protein Services for CIC
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CIC 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CIC for ontologies           About GeneDecksing



    CIC Antibody Products: 
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    Cloud-Clone Corp. ELISAs for CIC 
    Cloud-Clone Corp. CLIAs for CIC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry Q96RK0

    ProtoNet protein and cluster: Q96RK0

    1 Blocks protein domain: IPB002345 Lipocalin signature

    UniProtKB/Swiss-Prot: CIC_HUMAN, Q96RK0
    Similarity: Contains 1 HMG box DNA-binding domain


    CIC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIC_HUMAN, Q96RK0
    Function: Transcriptional repressor which may play a role in development of the central nervous system (CNS)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16713569
         
    CIC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CIC:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cic):
     behavior/neurological  growth/size  mortality/aging  nervous system  respiratory system 

    CIC for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CIC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CIC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIC 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CIC
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate CIC (see all 50):
    hsa-miR-2052 hsa-miR-142-5p hsa-miR-3152-3p hsa-miR-1307 hsa-miR-4307 hsa-miR-19b-2* hsa-miR-330-5p hsa-miR-548k
    SwitchGear 3'UTR luciferase reporter plasmidCIC 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CIC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/39 Interacting proteins for CIC (Q96RK01, 2, 3 ENSP000001607404) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-945857,EBI-930964 MINT-2870723 MINT-2862865 MINT-2870685 MINT-2870704 MINT-2870742 I2D: score=3 STRING: ENSP00000244769
    CSNK2BP678702, 3MINT-8253154 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253154 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253154 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253154 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    CIC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CIC

    Search CenterWatch for drugs/clinical trials and news about CIC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CIC gene: 
    NM_015125.3  

    Unigene Cluster for CIC:

    Capicua transcriptional repressor
    Hs.388236  [show with all ESTs]
    Unigene Representative Sequence: NM_015125
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572681 ENST00000571942 ENST00000575839 ENST00000160740(uc002otf.1)
    ENST00000575354 ENST00000573349 ENST00000576505 ENST00000575287 ENST00000571033

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CIC
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate CIC (see all 50):
    hsa-miR-2052 hsa-miR-142-5p hsa-miR-3152-3p hsa-miR-1307 hsa-miR-4307 hsa-miR-19b-2* hsa-miR-330-5p hsa-miR-548k
    SwitchGear 3'UTR luciferase reporter plasmidCIC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CIC
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CIC (NM_015125)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIC
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CIC
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIC

    Additional mRNA sequence: 

    AB002304.1 AF363689.1 AK025939.1 

    6 DOTS entries:

    DT.214783  DT.100714345  DT.65285627  DT.95272251  DT.121501873  DT.100646739 

    24/215 AceView cDNA sequences (see all 215):

    AI492286 BQ893460 AI468652 BU542283 BQ182225 AA364034 BQ721422 BQ279057 
    BM352665 BF971330 BQ269969 CK823031 AB002304 AI431516 AF363689 BU160807 
    BQ707646 AW055303 BM680202 BM553258 BQ086251 BQ893906 AI479624 CK823030 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CIC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for CIC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CIC expression in normal human tissues (normalized intensities)      CIC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAATATTT
    CIC Expression
    About this image


    CIC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             epididymis ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, pre-menopause ; glandular cells   

    See CIC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CIC

    SOURCE GeneReport for Unigene cluster: Hs.388236

    UniProtKB/Swiss-Prot: CIC_HUMAN, Q96RK0
    Tissue specificity: Expressed in fetal brain

        SABiosciences Custom PCR Arrays for CIC
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CIC gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cic1 , 5 capicua homolog (Drosophila)1, 5 88.04(n)1
    92.56(a)1
      7 (13.73 cM)5
    717221  NM_001110131.11  NP_001103601.11 
     252677045 
    lizard
    (Anolis carolinensis)
    Reptilia CIC6
    capicua transcriptional repressor
    1(a)
    1 ↔ 1
    AAWZ02040460(2022-6141)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.138632 Transcribed sequence with moderate similarity to protein more 76.39(n)    CD591325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cic3 negative regulation of transcription
    transcription more
    63(a)   3 92E2   --
    worm
    (Caenorhabditis elegans)
    Secernentea gei-33 HMG box transcription factor 48(a)   X(12831534-12838140)   --


    ENSEMBL Gene Tree for CIC (if available)
    TreeFam Gene Tree for CIC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CIC gene
    BBX2  
    7 SIMAP similar genes for CIC using alignment to 7 protein entries:     CIC_HUMAN (see all proteins):
    CIC/DUX4 fusion    BBX    TCF7L2    HBP1    soxB    TCF7
    SRY

    CIC for paralogs           About GeneDecksing


    5/20 Pseudogenes.org Pseudogenes for CIC (see all 20)
    PGOHUM00000238422 PGOHUM00000244468 PGOHUM00000244554 PGOHUM00000245214 PGOHUM00000245217


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/462 SNPs in CIC are shown (see all 462)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359374
    A breast cancer sample4--see VAR_0359372 A T mis40--------
    VAR_0359364
    A breast cancer sample4--see VAR_0359362 E K mis40--------
    VAR_0650904
    ----see VAR_0650902 R W mis40--------
    rs1389084401,2
    --39216959(+) CCAGGC/GCCCCT 1 -- int10--------
    rs1117551591,2
    C,F--39217064(+) CGTGGC/GTCTGT 1 -- int12Minor allele frequency- G:0.02NA 122
    rs1417246291,2
    --39217147(+) GAGTAA/GTGGAA 1 -- int10--------
    rs755767341,2
    F--42786871(+) ATTCAG/ATCTCT 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1116602031,2
    C,F--42787134(+) GTCCAG/CAGTGG 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs355906801,2
    C--42787198(+) TATACC/TTGATG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1932705371,2
    --42787262(+) GGGGTA/CGGTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CIC (42772689 - 42799949 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CIC:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422471CNV Deletion17116639
    nsv520239CNV Loss19592680
    nsv911787CNV Loss21882294
    nsv833834CNV Loss17160897
    dgv3884n71CNV Loss21882294
    nsv911782CNV Loss21882294
    nsv911785CNV Loss21882294
    nsv522854CNV Gain19592680
    nsv526186CNV Gain19592680
    esv28255CNV Gain19812545


    Human Gene Mutation Database (HGMD): CIC
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CIC
    DNA2.0 Custom Variant and Variant Library Synthesis for CIC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612082    OMIM disorders: --

    7 diseases for CIC:    About MalaCards
    pityriasis versicolor    oligodendroglioma    medulloblastoma    mental retardation
    astrocytoma    sarcoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CIC:
    Pityriasis versicolor

    CIC for disorders           About GeneDecksing

    Genetic Association Database (GAD): CIC
    Human Genome Epidemiology (HuGE) Navigator: CIC (13 documents)

    Export disorders for CIC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CIC gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with CIC)
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    1. CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. (PubMed id 15981098)1, 2, 3 Lee C.J....Scotting P.J. (2005)
    2. CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. (PubMed id 12393275)1, 2, 3 Lee C.-J.... Scotting P.J. (2002)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
    7. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine th e classification of malignant gliomas. (PubMed id 22869205)1 Jiao Y....Yan H. (2012)
    8. Concurrent CIC mutations, IDH mutations, and 1p/19q l oss distinguish oligodendrogliomas from other cancers. (PubMed id 22072542)1 Yip S....Marra M.A. (2012)
    9. CIC and FUBP1 mutations in oligodendrogliomas, oligoas trocytomas and astrocytomas. (PubMed id 22588899)1 Sahm F....Hartmann C. (2012)
    10. Mutations in CIC and FUBP1 contribute to human oligod endroglioma. (PubMed id 21817013)1 Bettegowda C....Kinzler K.W. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23152 HGNC: 14214 AceView: CIC Ensembl:ENSG00000079432 euGenes: HUgn23152
    ECgene: CIC H-InvDB: CIC

    (According to HUGE)
    About This Section
    HUGE: KIAA0306

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CIC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CIC gene:
    Search GeneIP for patents involving CIC

    GeneCards and IP:
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