Aliases for CIC Gene
Aliases for CIC Gene
External Ids for CIC Gene
- HGNC: 14214
- Entrez Gene: 23152
- Ensembl: ENSG00000079432
- OMIM: 612082
- UniProtKB: Q96RK0
Previous GeneCards Identifiers for CIC Gene
- GC19P043435
- GC19P043180
- GC19P047454
- GC19P047480
- GC19P042788
- GC19P039219
- GC19P042772
Summaries for CIC Gene
-
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
GeneCards Summary for CIC Gene
CIC (Capicua Transcriptional Repressor) is a Protein Coding gene. Diseases associated with CIC include Superficial Mycosis and Pityriasis Versicolor. GO annotations related to this gene include chromatin binding. An important paralog of this gene is BBX.
UniProtKB/Swiss-Prot for CIC Gene
-
Transcriptional repressor which may play a role in development of the central nervous system (CNS).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIC Gene
Genomics for CIC Gene
Regulatory Elements for CIC Gene
Enhancers for CIC Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CIC on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CIC gene promoter:
Regulatory Element Products
Genomic Location for CIC Gene
- Chromosome:
- 19
- Start:
- 42,268,537 bp from pter
- End:
- 42,295,797 bp from pter
- Size:
- 27,261 bases
- Orientation:
- Plus strand
Genomic View for CIC Gene
Genes around CIC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
CIC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CIC Gene
Proteins for CIC Gene
-
Protein details for CIC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96RK0-CIC_HUMAN
- Recommended name:
- Protein capicua homolog
- Protein Accession:
- Q96RK0
- Q7LGI1
- Q9UEG5
- Q9Y6T1
Protein attributes for CIC Gene
- Size:
- 1608 amino acids
- Molecular mass:
- 163820 Da
- Quaternary structure:
-
- Interacts with ATXN1 and ATXN1L.
- Miscellaneous:
-
- Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage.
- SequenceCaution:
-
- Sequence=AAD11988.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for CIC Gene
Post-translational modifications for CIC Gene
Other Protein References for CIC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CIC
-
Custom Antibody ServicesOriGene Antibodies for CIC
- Novus Biologicals Antibodies for CIC
-
Abcam antibodies for CIC
- Invitrogen Antibodies for CIC
- antibodies-online Antibodies for CIC: See all 53
- GeneTex CIC antibody for CIC
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CIC
- Origene Custom Protein Services for CIC
- Novus Biologicals proteins for CIC
- Search GeneTex for Proteins for CIC
Assay Products
- antibodies-online Kits for CIC: See all 3
No data available for DME Specific Peptides for CIC Gene
Domains & Families for CIC Gene
Protein Domains for CIC Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CIC Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CIC Gene
Function for CIC Gene
Molecular function for CIC Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor which may play a role in development of the central nervous system (CNS).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16713569 |
Phenotypes for CIC Gene
- MGI mutant phenotypes for CIC:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CIC:
-
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- FOXO1 nuclear localization
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased Nanog expression
- Negative genetic interaction between BLM-/- and BLM+/+
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CIC
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CIC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CIC gene
- Search ViGene Biosciences for CIC
CRISPR Products
-
OriGene CRISPR knockouts for CIC
-
Santa Cruz Biotechnology (SCBT) CRISPR for CIC
- GenScript: Design CRISPR guide RNA sequences for CIC
miRNA for CIC Gene
- miRTarBase miRNAs that target CIC
-
- hsa-mir-615-3p (MIRT040419)
- hsa-mir-18a-3p (MIRT040881)
- hsa-mir-193b-3p (MIRT041548)
- hsa-mir-25-3p (MIRT082430)
- hsa-mir-32-5p (MIRT082431)
- hsa-mir-92a-3p (MIRT082432)
- hsa-mir-363-3p (MIRT082433)
- hsa-mir-367-3p (MIRT082434)
- hsa-mir-92b-3p (MIRT082435)
- hsa-mir-5589-3p (MIRT082436)
- hsa-mir-6815-3p (MIRT082437)
- hsa-mir-4638-5p (MIRT548826)
- hsa-mir-1307-3p (MIRT548827)
miRNA Products
- Search ViGene Biosciences for CIC
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CIC
- Browse OriGene Inhibitory RNA Products For CIC
-
ViGene Biosciences ready-to-package AAV shRNAs for CIC gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CIC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIC
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CIC
-
ViGene Biosciences adenoviral particle packaged cDNA for CIC gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CIC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CIC gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CIC Gene
Localization for CIC Gene
Subcellular locations from UniProtKB/Swiss-Prot for CIC Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for CIC Gene
No Data Available
Interacting Proteins for CIC Gene
Selected Interacting proteins:
Q96RK0-CIC_HUMAN
ENSP00000160740
for CIC Gene via
IID
UniProtKB
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source for CIC Gene
Transcripts for CIC Gene
mRNA/cDNA for CIC Gene
- (13) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (215) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CIC Gene
CRISPR Products
-
OriGene CRISPR knockouts for CIC
-
Santa Cruz Biotechnology (SCBT) CRISPR for CIC
- GenScript: Design CRISPR guide RNA sequences for CIC
miRNA Products
- Search ViGene Biosciences for CIC
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CIC
- Browse OriGene Inhibitory RNA Products For CIC
-
ViGene Biosciences ready-to-package AAV shRNAs for CIC gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CIC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIC
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for CIC Gene
This gene is overexpressed in Pancreas (16.3), Peripheral blood mononuclear cells (14.5), and Fetal testis (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CIC Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CIC Gene:
CICSOURCE GeneReport for Unigene cluster for CIC Gene:
Hs.388236mRNA Expression by UniProt/SwissProt for CIC Gene:
Q96RK0-CIC_HUMAN
Tissue specificity:
Expressed in fetal brain.
Evidence on tissue expression from TISSUES for CIC Gene
- Nervous system(4.5)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for CIC
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIC Gene
Orthologs for CIC Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CIC 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CIC 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cic 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cic 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CIC 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CIC 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CIC 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | cicb 35 |
|
OneToMany | |
| cica 35 |
|
OneToMany | |||
| Dr.13863 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | cic 36 35 |
|
||
| bbx 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | gei-3 36 35 |
|
- Species where no ortholog for CIC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for CIC Gene
(7) SIMAP similar genes for CIC Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for CIC Gene
- PGOHUM00000290770
- PGOHUM00000293678
- PGOHUM00000295160
- PGOHUM00000296087
- PGOHUM00000296168
- PGOHUM00000296174
- PGOHUM00000296182
- PGOHUM00000296778
- PGOHUM00000296781
- PGOHUM00000296847
- PGOHUM00000297035
- PGOHUM00000298368
- PGOHUM00000299327
- PGOHUM00000299971
- PGOHUM00000300854
- PGOHUM00000301639
- PGOHUM00000302109
- PGOHUM00000302126
- PGOHUM00000302229
- PGOHUM00000302417
- PGOHUM00000302622
- PGOHUM00000302637
- PGOHUM00000302641
- PGOHUM00000302646
- PGOHUM00000302660
- PGOHUM00000304069
- PGOHUM00000306689
- PGOHUM00000305574
- PGOHUM00000305761
- PGOHUM00000289807
Variants for CIC Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs770323488 | A breast cancer sample | 42,290,722(+) | CCCCC(A/C/G)CCCCA | nc-transcript-variant, reference, missense | |
| VAR_035936 | A breast cancer sample | ||||
| rs745695673 | Uncertain significance | 42,295,147(+) | AGCCC(C/T)CCCCC | reference, missense | |
| rs797044893 | Uncertain significance | 42,292,968(+) | CATGA(C/T)CTACA | nc-transcript-variant, reference, missense, utr-variant-3-prime | |
| rs139337301 | untested | 42,290,747(+) | GGCCC(C/T)AGCAG | nc-transcript-variant, reference, missense |
Residual Variation Intolerance Score:
0.452% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.22;
52.40% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CIC Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIC Gene
Disorders for CIC Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| superficial mycosis |
|
|
| pityriasis versicolor |
|
|
| oligodendroglioma |
|
|
| spinocerebellar ataxia 1 |
|
|
Search CIC in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CIC
No data available for UniProtKB/Swiss-Prot and Genatlas for CIC Gene
Publications for CIC Gene
- CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. (PMID: 15981098) Lee C.-J. … Scotting P.J. (J. Neurooncol. 2005) 2 3 4 64
- CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. (PMID: 12393275) Lee C.-J. … Scotting P.J. (Brain Res. Mol. Brain Res. 2002) 2 3 4 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
Products for CIC Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Browse ELISAs
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- Custom Antibody ServicesOriGene Antibodies for CIC
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CIC
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- GenScript: Design CRISPR guide RNA sequences for CIC
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- CloneReady with Over 120,000 Genes
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CIC
- Novus Biologicals proteins for CIC
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for CIC: See all 53
- antibodies-online Kits for CIC: See all 3
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex CIC antibody for CIC
- Search GeneTex for Proteins for CIC
- ViGene Biosciences adenoviral particle packaged cDNA for CIC gene
- ViGene Biosciences lentiviral particle packaged cDNA for CIC gene
- ViGene Biosciences ready-to-package AAV shRNAs for CIC gene
- Search ViGene Biosciences for CIC
- Horizon Cell Lines for CIC
- Cyagen custom Knockout/knockin (KOKI) mouse models for CIC
- VectorBuilder custom plasmid, inducible vectors for CIC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIC
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CIC Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (154) TISSUES
- (155) Gene ORGANizer