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Aliases for CIC Gene

Aliases for CIC Gene

  • Capicua Transcriptional Repressor 2 3
  • KIAA0306 4 6
  • Capicua (Drosophila) Homolog 2
  • Capicua Homolog (Drosophila) 2

External Ids for CIC Gene

Previous GeneCards Identifiers for CIC Gene

  • GC19P043435
  • GC19P043180
  • GC19P047454
  • GC19P047480
  • GC19P042788
  • GC19P039219
  • GC19P042772

Summaries for CIC Gene

Entrez Gene Summary for CIC Gene

  • The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

GeneCards Summary for CIC Gene

CIC (Capicua Transcriptional Repressor) is a Protein Coding gene. Diseases associated with CIC include pityriasis versicolor and oligoastrocytoma. An important paralog of this gene is BBX.

UniProtKB/Swiss-Prot for CIC Gene

  • Transcriptional repressor which may play a role in development of the central nervous system (CNS)

Gene Wiki entry for CIC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIC Gene

Genomics for CIC Gene

Regulatory Elements for CIC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CIC Gene

Start:
42,268,537 bp from pter
End:
42,295,797 bp from pter
Size:
27,261 bases
Orientation:
Plus strand

Genomic View for CIC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIC Gene

Proteins for CIC Gene

  • Protein details for CIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RK0-CIC_HUMAN
    Recommended name:
    Protein capicua homolog
    Protein Accession:
    Q96RK0
    Secondary Accessions:
    • Q7LGI1
    • Q9UEG5
    • Q9Y6T1

    Protein attributes for CIC Gene

    Size:
    1608 amino acids
    Molecular mass:
    163820 Da
    Quaternary structure:
    • Interacts with ATXN1 and ATXN1L.
    Miscellaneous:
    • Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage
    SequenceCaution:
    • Sequence=AAD11988.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CIC Gene

neXtProt entry for CIC Gene

Proteomics data for CIC Gene at MOPED

Post-translational modifications for CIC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CIC Gene

Domains for CIC Gene

Protein Domains for CIC Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RK0

UniProtKB/Swiss-Prot:

CIC_HUMAN :
  • Q96RK0
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with CIC: view

No data available for Gene Families for CIC Gene

Function for CIC Gene

Molecular function for CIC Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor which may play a role in development of the central nervous system (CNS)

Gene Ontology (GO) - Molecular Function for CIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with CIC: view
genes like me logo Genes that share phenotypes with CIC: view

Animal Model Products

miRNA for CIC Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CIC Gene

Localization for CIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIC Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIC Gene COMPARTMENTS Subcellular localization image for CIC gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with CIC: view

Pathways for CIC Gene

SuperPathways for CIC Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0048286 lung alveolus development IEA --
genes like me logo Genes that share ontologies with CIC: view

No data available for Pathways by source for CIC Gene

Transcripts for CIC Gene

Unigene Clusters for CIC Gene

Capicua transcriptional repressor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIC

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CIC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for CIC Gene

GeneLoc Exon Structure for
CIC
ECgene alternative splicing isoforms for
CIC

Expression for CIC Gene

mRNA expression in normal human tissues for CIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CIC Gene

SOURCE GeneReport for Unigene cluster for CIC Gene Hs.388236

mRNA Expression by UniProt/SwissProt for CIC Gene

Q96RK0-CIC_HUMAN
Tissue specificity: Expressed in fetal brain.
genes like me logo Genes that share expressions with CIC: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CIC Gene

Orthologs for CIC Gene

This gene was present in the common ancestor of animals.

Orthologs for CIC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIC 35
  • 99.59 (n)
  • 99.75 (a)
CIC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CIC 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIC 35
  • 90.22 (n)
  • 94.27 (a)
CIC 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cic 35
  • 87.72 (n)
  • 92.07 (a)
Cic 16
Cic 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CIC 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cic 35
  • 87.97 (n)
  • 92.25 (a)
lizard
(Anolis carolinensis)
Reptilia CIC 36
  • 17 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cica 36
  • 22 (a)
OneToMany
cicb 36
  • 23 (a)
OneToMany
Dr.13863 35
fruit fly
(Drosophila melanogaster)
Insecta bbx 36
  • 8 (a)
ManyToMany
cic 36
  • 11 (a)
ManyToMany
cic 37
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea gei-3 36
  • 15 (a)
OneToMany
gei-3 37
  • 48 (a)
Species with no ortholog for CIC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CIC Gene

ENSEMBL:
Gene Tree for CIC (if available)
TreeFam:
Gene Tree for CIC (if available)

Paralogs for CIC Gene

Paralogs for CIC Gene

Selected SIMAP similar genes for CIC Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CIC: view

Variants for CIC Gene

Sequence variations from dbSNP and Humsavar for CIC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs851608 -- 42,288,696(+) GCAAC(C/T)CCAGA intron-variant
rs1052023 -- 42,294,897(+) AAGAT(C/T)CGTGA reference, synonymous-codon
rs1052054 -- 42,295,562(+) TTTTT(C/T)CCCAG utr-variant-3-prime
rs1052064 -- 42,295,614(+) ACTTT(G/T)CCACA utr-variant-3-prime
rs2075086 -- 42,293,321(+) ACTTG(A/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIC Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
nsv520239 CNV Loss 19592680
nsv911782 CNV Loss 21882294
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
nsv833834 CNV Loss 17160897
dgv3884n71 CNV Loss 21882294
nsv911785 CNV Loss 21882294
nsv911787 CNV Loss 21882294
esv28255 CNV Gain 19812545

Relevant External Links for CIC Gene

HapMap Linkage Disequilibrium report
CIC
Human Gene Mutation Database (HGMD)
CIC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIC Gene

Disorders for CIC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CIC Gene including...

Search for CIC Gene in MalaCards »

(1) University of Copenhagen DISEASES for CIC Gene

Relevant External Links for CIC

Genetic Association Database (GAD)
CIC
Human Genome Epidemiology (HuGE) Navigator
CIC
genes like me logo Genes that share disorders with CIC: view

No data available for UniProtKB/Swiss-Prot for CIC Gene

Publications for CIC Gene

  1. CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. (PMID: 12393275) Lee C.-J. … Scotting P.J. (Brain Res. Mol. Brain Res. 2002) 2 3 4
  2. CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. (PMID: 15981098) Lee C.-J. … Scotting P.J. (J. Neurooncol. 2005) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for CIC Gene

Sources for CIC Gene

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