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CIC Gene

protein-coding   GIFtS: 60
GCID: GC19P042772

Capicua Transcriptional Repressor

(Previous names: capicua (Drosophila) homolog, capicua homolog (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Capicua Transcriptional Repressor1 2
KIAA03063 5
Capicua (Drosophila) Homolog1
Capicua Homolog (Drosophila)1
Capicua Homolog2
Protein Capicua Homolog2

External Ids:    HGNC: 142141   Entrez Gene: 231522   Ensembl: ENSG000000794327   OMIM: 6120825   UniProtKB: Q96RK03   

Export aliases for CIC gene to outside databases

Previous GC identifers: GC19P043435 GC19P043180 GC19P047454 GC19P047480 GC19P042788 GC19P039219


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CIC Gene:
CIC (capicua transcriptional repressor) is a protein-coding gene. Diseases associated with CIC include pityriasis versicolor, and oligoastrocytoma. An important paralog of this gene is BBX.

UniProtKB/Swiss-Prot: CIC_HUMAN, Q96RK0
Function: Transcriptional repressor which may play a role in development of the central nervous system (CNS)

Gene Wiki entry for CIC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CIC gene promoter:
         CREB   TBP   AREB6   deltaCREB   c-Myb   Ik-3   Roaz   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CIC promoter sequence
   Search Chromatin IP Primers for CIC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CIC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042772:  view genomic region     (about GC identifiers)

Start:
42,772,689 bp from pter      End:
42,799,949 bp from pter
Size:
27,261 bases      Orientation:
plus strand

1 alternative location:
Chr7-,CRA_TCAG 62,567,254-62,569,083     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CIC_HUMAN, Q96RK0 (See protein sequence)
Recommended Name: Protein capicua homolog  
Size: 1608 amino acids; 163820 Da
Subunit: Interacts with ATXN1 and ATXN1L (By similarity)
Miscellaneous: Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage
Sequence caution: Sequence=AAD11988.1; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for CIC:
2M41 (3D)        4J2J (3D)        4J2L (3D)    
Secondary accessions: Q7LGI1 Q9UEG5 Q9Y6T1

Explore the universe of human proteins at neXtProt for CIC: NX_Q96RK0

Explore proteomics data for CIC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CIC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055940.3  
    ENSEMBL proteins: 
     ENSP00000459719   ENSP00000459704   ENSP00000160740   ENSP00000458663   ENSP00000458543  
     ENSP00000459011   ENSP00000460230  

    CIC Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CIC

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    Abcam antibodies for CIC
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    ThermoFisher Antibodies for CIC
    LSBio Antibodies in human, mouse, rat for CIC

    CIC Assay Products:

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    Cloud-Clone Corp. CLIAs for CIC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry Q96RK0

    ProtoNet protein and cluster: Q96RK0

    1 Blocks protein domain: IPB002345 Lipocalin signature

    UniProtKB/Swiss-Prot: CIC_HUMAN, Q96RK0
    Similarity: Contains 1 HMG box DNA-binding domain


    CIC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIC_HUMAN, Q96RK0
    Function: Transcriptional repressor which may play a role in development of the central nervous system (CNS)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16713569
         
    CIC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CIC:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cic):
     behavior/neurological  growth/size/body  mortality/aging  nervous system  respiratory system 

    CIC for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CIC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CIC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIC

    miRNA
    Products:
        
    miRTarBase miRNAs that target CIC:
    hsa-mir-18a-3p (MIRT040881), hsa-mir-615-3p (MIRT040419), hsa-mir-193b-3p (MIRT041548)

    Block miRNA regulation of human, mouse, rat CIC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CIC (see all 50):
    hsa-miR-2052 hsa-miR-142-5p hsa-miR-3152-3p hsa-miR-1307 hsa-miR-4307 hsa-miR-19b-2* hsa-miR-330-5p hsa-miR-548k
    SwitchGear 3'UTR luciferase reporter plasmidCIC 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CIC
    Predesigned siRNA for gene silencing in human, mouse, rat CIC

    Gene Editing
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    OriGene ORF clones in mouse, rat for CIC
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    GenScript: all cDNA clones in your preferred vector: CIC (NM_015125)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIC

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CIC
    Browse ESI BIO Cell Lines and PureStem Progenitors for CIC 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CIC_HUMAN, Q96RK0: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CIC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CIC
    Interactions:

        Search GeneGlobe Interaction Network for CIC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CIC (Q96RK01, 2, 3 ENSP000001607404) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-945857,EBI-930964 MINT-2870723 MINT-2862865 MINT-2870685 MINT-2870704 MINT-2870742 I2D: score=3 STRING: ENSP00000244769
    CSNK2BP678702, 3MINT-8253154 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253154 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253154 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253154 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    CIC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CIC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CIC gene: 
    NM_015125.3  

    Unigene Cluster for CIC:

    Capicua transcriptional repressor
    Hs.388236  [show with all ESTs]
    Unigene Representative Sequence: NM_015125
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572681 ENST00000571942 ENST00000575839 ENST00000160740(uc002otf.1)
    ENST00000575354 ENST00000573349 ENST00000576505 ENST00000575287 ENST00000571033

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CIC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CIC (see all 50):
    hsa-miR-2052 hsa-miR-142-5p hsa-miR-3152-3p hsa-miR-1307 hsa-miR-4307 hsa-miR-19b-2* hsa-miR-330-5p hsa-miR-548k
    SwitchGear 3'UTR luciferase reporter plasmidCIC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CIC
    Predesigned siRNA for gene silencing in human, mouse, rat CIC
    Clone
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    OriGene ORF clones in mouse, rat for CIC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CIC (NM_015125)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIC
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CIC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CIC
      QuantiTect SYBR Green Assays in human, mouse, rat CIC
      QuantiFast Probe-based Assays in human, mouse, rat CIC

    Additional mRNA sequence: 

    AB002304.1 AF363689.1 AK025939.1 

    6 DOTS entries:

    DT.214783  DT.100714345  DT.65285627  DT.95272251  DT.121501873  DT.100646739 

    Selected AceView cDNA sequences (see all 215):

    BQ721422 BQ086251 AA364034 CB321879 AI823448 AI199740 BM680202 AW055303 
    BQ102349 BQ269969 CA425854 AB002304 AI936750 BQ895946 AW002465 CB963527 
    AI521565 AI431516 AF363689 BU160807 BQ286626 AA419377 BM465442 AI479624 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CIC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for CIC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CIC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAATATTT
    CIC Expression
    About this image


    CIC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CIC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CIC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388236

    UniProtKB/Swiss-Prot: CIC_HUMAN, Q96RK0
    Tissue specificity: Expressed in fetal brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CIC gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cic1 , 5 capicua homolog (Drosophila)1, 5 87.72(n)1
    92.07(a)1
      7 (13.73 cM)5
    717221  NM_001110132.11  NP_001103602.11 
     252677045 
    lizard
    (Anolis carolinensis)
    Reptilia CIC6
    capicua transcriptional repressor
    17(a)
    1 ↔ 1
    AAWZ02040460(2022-6141)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.138632 Transcribed sequence with moderate similarity to protein more 76.39(n)    CD591325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cic3 negative regulation of transcription
    transcription more
    63(a)   3 92E2   --
    worm
    (Caenorhabditis elegans)
    Secernentea gei-33 HMG box transcription factor 48(a)   X(12831534-12838140)   --


    ENSEMBL Gene Tree for CIC (if available)
    TreeFam Gene Tree for CIC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CIC gene
    BBX2  
    7 SIMAP similar genes for CIC using alignment to 6 protein entries:     CIC_HUMAN (see all proteins):
    CIC/DUX4 fusion    BBX    TCF7L2    soxB    TCF7    HBP1
    SRY

    CIC for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for CIC (see all 20)
    PGOHUM00000238422 PGOHUM00000244468 PGOHUM00000244554 PGOHUM00000245214 PGOHUM00000245217


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CIC (see all 462)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359374
    A breast cancer sample4--see VAR_0359372 A T mis40--------
    VAR_0359364
    A breast cancer sample4--see VAR_0359362 E K mis40--------
    rs1389084401,2
    --39216959(+) CCAGGC/GCCCCT 1 -- int10--------
    rs1117551591,2
    C,F--39217064(+) CGTGGC/GTCTGT 1 -- int12Minor allele frequency- G:0.02NA 122
    rs1417246291,2
    --39217147(+) GAGTAA/GTGGAA 1 -- int10--------
    rs755767341,2
    F--42786871(+) ATTCAG/ATCTCT 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1116602031,2
    C,F--42787134(+) GTCCAG/CAGTGG 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs355906801,2
    C--42787198(+) TATACC/TTGATG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1932705371,2
    --42787262(+) GGGGTA/CGGTAT 1 -- us2k10--------
    rs735528811,2
    C,F--42787490(+) GGCGAA/GGCATG 1 -- us2k15Minor allele frequency- G:0.06WA CSA NA EA 361

    HapMap Linkage Disequilibrium report for CIC (42772689 - 42799949 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CIC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422471CNV Deletion17116639
    nsv520239CNV Loss19592680
    nsv911787CNV Loss21882294
    nsv833834CNV Loss17160897
    dgv3884n71CNV Loss21882294
    nsv911782CNV Loss21882294
    nsv911785CNV Loss21882294
    nsv522854CNV Gain19592680
    nsv526186CNV Gain19592680
    esv28255CNV Gain19812545

    Human Gene Mutation Database (HGMD): CIC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CIC
    DNA2.0 Custom Variant and Variant Library Synthesis for CIC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612082    OMIM disorders: --

    15 diseases for CIC:    
    About MalaCards
    pityriasis versicolor    oligoastrocytoma    oligodendroglioma    medulloblastoma
    astrocytoma    breast and colorectal cancer    malignant glioma    mental retardation
    ataxia    sarcoma    cerebritis    colorectal cancer
    thyroiditis    neuronitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for CIC:
    Pityriasis versicolor

    CIC for disorders           About GeneDecksing

    Genetic Association Database (GAD): CIC
    Human Genome Epidemiology (HuGE) Navigator: CIC (13 documents)

    Export disorders for CIC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CIC gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with CIC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. (PubMed id 15981098)1, 2, 3 Lee C.-J.... Scotting P.J. (J. Neurooncol. 2005)
    2. CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. (PubMed id 12393275)1, 2, 3 Lee C.-J.... Scotting P.J. (Brain Res. Mol. Brain Res. 2002)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (DNA Res. 1997)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: a novel highly aggressive soft tissue tumor with distinctive histopathology. (PubMed id 23887164)1 Choi E.Y....Lucas D.R. (Am. J. Surg. Pathol. 2013)
    9. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. (PubMed id 22869205)1 Jiao Y....Yan H. (Oncotarget 2012)
    10. Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. (PubMed id 22072542)1 Yip S....Marra M.A. (J. Pathol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23152 HGNC: 14214 AceView: CIC Ensembl:ENSG00000079432 euGenes: HUgn23152
    ECgene: CIC H-InvDB: CIC

    (According to HUGE)
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    HUGE: KIAA0306

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CIC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CIC gene:
    Search GeneIP for patents involving CIC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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