Aliases for CIB4 Gene
Aliases for CIB4 Gene
External Ids for CIB4 Gene
- HGNC: 33703
- Entrez Gene: 130106
- Ensembl: ENSG00000157884
- OMIM: 610646
- UniProtKB: A0PJX0
Previous GeneCards Identifiers for CIB4 Gene
- GC02M026716
- GC02M026804
Summaries for CIB4 Gene
GeneCards Summary for CIB4 Gene
CIB4 (Calcium And Integrin Binding Family Member 4) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CIB1.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIB4 Gene
Genomics for CIB4 Gene
Regulatory Elements for CIB4 Gene
Enhancers for CIB4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G026685 | 0.6 | dbSUPER | 15.9 | -45.6 | -45582 | 3.8 | CTCF SOX13 MTA2 MIER2 CEBPG EZH2 | CIB4 DPYSL5 MAPRE3 RPL37P11 KCNK3 |
| GH02G026609 | 0.7 | ENCODE | 11.8 | +31.3 | 31297 | 1.8 | ZNF3 RARA TEAD3 GATA3 NCOR1 HNF4A BCL6 NR2F6 FOXP2 MAFK | CIB4 KCNK3 C2orf70 GC02P026627 |
| GH02G026689 | 0.6 | dbSUPER | 10.4 | -48.5 | -48475 | 0.5 | MXI1 SMC3 RBBP5 EP300 RAD21 EZH2 | CIB4 DPYSL5 KCNK3 RPL37P11 |
| GH02G026703 | 0.9 | ENCODE dbSUPER | 6.2 | -64.7 | -64748 | 4.4 | BCOR SMARCA5 ESRRA ZMYM3 CEBPB ATF2 ZIC2 NR2F2 ZFHX2 EGR2 | CIB4 GC02P026705 SLC35F6 |
| GH02G026691 | 0.9 | ENCODE dbSUPER | 5.7 | -50.7 | -50729 | 1.4 | CTCF MAZ SP3 KLF1 RBBP5 REST HDAC2 PRDM1 ZBTB26 WT1 | CIB4 KCNK3 RPL37P11 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CIB4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CIB4 gene promoter:
Regulatory Element Products
Genomic Location for CIB4 Gene
- Chromosome:
- 2
- Start:
- 26,573,764 bp from pter
- End:
- 26,641,411 bp from pter
- Size:
- 67,648 bases
- Orientation:
- Minus strand
Genomic View for CIB4 Gene
Genes around CIB4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p23.3 by Ensembl
- 2p23.3 by Entrez Gene
- 2p23.3 by HGNC
CIB4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CIB4 Gene
Proteins for CIB4 Gene
-
Protein details for CIB4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A0PJX0-CIB4_HUMAN
- Recommended name:
- Calcium and integrin-binding family member 4
- Protein Accession:
- A0PJX0
- B2RU18
Protein attributes for CIB4 Gene
- Size:
- 185 amino acids
- Molecular mass:
- 21745 Da
- Quaternary structure:
-
- Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium- and magnesium-dependent manner.
- Miscellaneous:
-
- The binding of either calcium or magnesium may significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).
Post-translational modifications for CIB4 Gene
Other Protein References for CIB4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CIB4
- Novus Biologicals Antibodies for CIB4
- Invitrogen Antibodies for CIB4
- Search GeneTex for Antibodies for CIB4
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CIB4
- Origene Custom Protein Services for CIB4
- Search GeneTex for Proteins for CIB4
Assay Products
No data available for DME Specific Peptides for CIB4 Gene
Domains & Families for CIB4 Gene
Gene Families for CIB4 Gene
Protein Domains for CIB4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CIB4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CIB4 Gene
Function for CIB4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 22779914 |
| GO:0005509 | calcium ion binding | IEA,IDA | 22779914 |
| GO:0005515 | protein binding | IPI | 22779914 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CIB4 Gene
- GenomeRNAi human phenotypes for CIB4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CIB4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CIB4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CIB4 gene
- Search ViGene Biosciences for CIB4
CRISPR Products
-
OriGene CRISPR knockouts for CIB4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CIB4
- GenScript: Design CRISPR guide RNA sequences for CIB4
miRNA Products
- Search ViGene Biosciences for CIB4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CIB4
- Browse OriGene Inhibitory RNA Products For CIB4
-
ViGene Biosciences ready-to-package AAV shRNAs for CIB4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CIB4
- VectorBuilder custom plasmid, inducible vectors for CIB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIB4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CIB4
-
ViGene Biosciences adenoviral particle packaged cDNA for CIB4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CIB4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CIB4 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CIB4 Gene
Localization for CIB4 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CIB4 Gene
Pathways & Interactions for CIB4 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for CIB4 Gene
Transcripts for CIB4 Gene
mRNA/cDNA for CIB4 Gene
- (6) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (19) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CIB4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CIB4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CIB4
- GenScript: Design CRISPR guide RNA sequences for CIB4
miRNA Products
- Search ViGene Biosciences for CIB4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CIB4
- Browse OriGene Inhibitory RNA Products For CIB4
-
ViGene Biosciences ready-to-package AAV shRNAs for CIB4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CIB4
- VectorBuilder custom plasmid, inducible vectors for CIB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIB4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CIB4 Gene
mRNA differential expression in normal tissues according to GTEx for CIB4 Gene
This gene is overexpressed in Testis (x31.9) and Adrenal Gland (x7.6).
NURSA nuclear receptor signaling pathways regulating expression of CIB4 Gene:
CIB4SOURCE GeneReport for Unigene cluster for CIB4 Gene:
Hs.591579Primer Products
-
OriGene qPCR primer pairs for CIB4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIB4 Gene
Orthologs for CIB4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CIB4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CIB4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CIB4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cib4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cib4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CIB4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CIB4 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG32812 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CNB1 35 |
|
OneToMany |
- Species where no ortholog for CIB4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CIB4 Gene
Variants for CIB4 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000019675 | -- | 26,597,363(+) | GAGTG(C/T)CGTGA | intron-variant | |
| rs1000043041 | -- | 26,636,220(+) | TCAGT(A/G)TTTAT | intron-variant | |
| rs1000053703 | -- | 26,642,048(+) | CGCAC(C/G)ACTGC | upstream-variant-2KB | |
| rs1000063551 | -- | 26,610,002(+) | CATTC(A/G)CTCCT | intron-variant | |
| rs1000136483 | -- | 26,614,736(+) | AGAGT(G/T)TCCTC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2663963 | CNV | deletion | 23128226 |
| esv2719826 | CNV | deletion | 23290073 |
| esv33316 | CNV | loss | 17666407 |
| esv3554088 | CNV | deletion | 23714750 |
| esv3590124 | CNV | gain | 21293372 |
| esv3590125 | CNV | loss | 21293372 |
| nsv1072931 | CNV | deletion | 25765185 |
| nsv1149075 | CNV | deletion | 26484159 |
| nsv2651 | CNV | deletion | 18451855 |
| nsv517800 | CNV | loss | 19592680 |
| nsv955044 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.03;
21.07% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CIB4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CIB4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIB4 Gene
Disorders for CIB4 Gene
Relevant External Links for CIB4
No disorders were found for CIB4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIB4 Gene
Publications for CIB4 Gene
- Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences. (PMID: 22779914) Huang H. … Vogel H.J. (Biochem. Cell Biol. 2012) 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. (PMID: 15574431) Gentry H.R. … Parise L.V. (J. Biol. Chem. 2005) 2 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- Genome-wide association study of periodontal pathogen colonization. (PMID: 22699663) Divaris K. … Offenbacher S. (J. Dent. Res. 2012) 3 64
Products for CIB4 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for CIB4
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CIB4
- Origene Custom Protein Services for CIB4
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- Browse OriGene Inhibitory RNA Products For CIB4
- OriGene qPCR primer pairs for CIB4
- OriGene CRISPR knockouts for CIB4
- OriGene ORF clones in human for CIB4
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- GenScript: Design CRISPR guide RNA sequences for CIB4
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- Novus Biologicals Antibodies for CIB4
- Novus Biologicals proteins and lysates for CIB4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Addgene plasmids for CIB4
- Search GeneTex for Antibodies for CIB4
- Search GeneTex for Proteins for CIB4
- ViGene Biosciences adenoviral particle packaged cDNA for CIB4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CIB4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CIB4 gene
- Search ViGene Biosciences for CIB4
- Horizon Cell Lines for CIB4
- Cyagen custom Knockout/knockin (KOKI) mouse models for CIB4
- VectorBuilder custom plasmid, inducible vectors for CIB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIB4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CIB4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (100) COMPARTMENTS
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- (110) PathCards
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