Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CIB4 Gene

Aliases for CIB4 Gene

  • Calcium And Integrin Binding Family Member 4 2 3 5
  • Calcium And Integrin-Binding Family Member 4 3
  • KIP4 3

External Ids for CIB4 Gene

Previous GeneCards Identifiers for CIB4 Gene

  • GC02M026716
  • GC02M026804

Summaries for CIB4 Gene

GeneCards Summary for CIB4 Gene

CIB4 (Calcium And Integrin Binding Family Member 4) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CIB1.

Additional gene information for CIB4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIB4 Gene

Genomics for CIB4 Gene

Regulatory Elements for CIB4 Gene

Enhancers for CIB4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H026609 0.7 ENCODE 11.8 +31.3 31297 1 ZNF3 RARA TEAD3 GATA3 HNF4A BCL6 NR2F6 KDM1A FOXP2 MAFK CIB4 KCNK3 C2orf70 GC02P026627
GH02H026685 0.5 dbSUPER 15.9 -45.6 -45582 3 SOX13 POLR2A RCOR1 MIER2 CEBPG CIB4 DPYSL5 MAPRE3 KCNK3 RPL37P11
GH02H026703 0.9 ENCODE dbSUPER 6.2 -64.7 -64748 4 BCOR SMARCA5 ZMYM3 REST ATF2 ZIC2 NR2F2 ZFHX2 EGR2 CIB4 GC02P026705 SLC35F6
GH02H026693 0.9 ENCODE dbSUPER 5.7 -54.8 -54770 4 NFYA JUN USF2 SIN3A RFX5 JUND NFYB FOSL2 FOS EZH2 CIB4 ENSG00000225378 KCNK3 GC02P026705
GH02H026691 0.9 ENCODE dbSUPER 5.7 -50.7 -50729 1 MAZ SP3 KLF1 REST PRDM1 ZBTB26 WT1 EZH2 CIB4 KCNK3 RPL37P11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CIB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CIB4 Gene

26,573,764 bp from pter
26,641,411 bp from pter
67,648 bases
Minus strand

Genomic View for CIB4 Gene

Genes around CIB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIB4 Gene

Proteins for CIB4 Gene

  • Protein details for CIB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium and integrin-binding family member 4
    Protein Accession:
    Secondary Accessions:
    • B2RU18

    Protein attributes for CIB4 Gene

    185 amino acids
    Molecular mass:
    21745 Da
    Quaternary structure:
    • Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium- and magnesium-dependent manner.
    • The binding of either calcium or magnesium may significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).

neXtProt entry for CIB4 Gene

Post-translational modifications for CIB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIB4 Gene

No data available for DME Specific Peptides for CIB4 Gene

Domains & Families for CIB4 Gene

Gene Families for CIB4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CIB4 Gene

Suggested Antigen Peptide Sequences for CIB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIB4: view

No data available for UniProtKB/Swiss-Prot for CIB4 Gene

Function for CIB4 Gene

Phenotypes From GWAS Catalog for CIB4 Gene

Gene Ontology (GO) - Molecular Function for CIB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 22779914
GO:0005509 calcium ion binding IDA 22779914
GO:0005515 protein binding IPI 22779914
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CIB4: view
genes like me logo Genes that share phenotypes with CIB4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CIB4
  • Applied Biological Materials Clones for CIB4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CIB4 Gene

Localization for CIB4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CIB4 gene
Compartment Confidence
extracellular 2
cytosol 2
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CIB4 Gene

Pathways & Interactions for CIB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIB4 Gene


No data available for Pathways by source and SIGNOR curated interactions for CIB4 Gene

Drugs & Compounds for CIB4 Gene

No Compound Related Data Available

Transcripts for CIB4 Gene

mRNA/cDNA for CIB4 Gene

Unigene Clusters for CIB4 Gene

Calcium and integrin binding family member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CIB4
  • Applied Biological Materials Clones for CIB4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CIB4 Gene

No ASD Table

Relevant External Links for CIB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CIB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CIB4 Gene

mRNA differential expression in normal tissues according to GTEx for CIB4 Gene

This gene is overexpressed in Testis (x31.9) and Adrenal Gland (x7.6).

NURSA nuclear receptor signaling pathways regulating expression of CIB4 Gene:


SOURCE GeneReport for Unigene cluster for CIB4 Gene:

genes like me logo Genes that share expression patterns with CIB4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIB4 Gene

Orthologs for CIB4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CIB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CIB4 33 34
  • 98.92 (n)
(Canis familiaris)
Mammalia CIB4 33 34
  • 90.58 (n)
(Bos Taurus)
Mammalia CIB4 33 34
  • 89.55 (n)
(Mus musculus)
Mammalia Cib4 33 16 34
  • 87.57 (n)
(Rattus norvegicus)
Mammalia Cib4 33
  • 87.57 (n)
(Monodelphis domestica)
Mammalia CIB4 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia CIB4 34
  • 79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32812 34
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 34
  • 27 (a)
Species where no ortholog for CIB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CIB4 Gene

Gene Tree for CIB4 (if available)
Gene Tree for CIB4 (if available)

Paralogs for CIB4 Gene

Paralogs for CIB4 Gene

(3) SIMAP similar genes for CIB4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CIB4: view

Variants for CIB4 Gene

Sequence variations from dbSNP and Humsavar for CIB4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000019675 -- 26,597,363(+) GAGTG(C/T)CGTGA intron-variant
rs1000043041 -- 26,636,220(+) TCAGT(A/G)TTTAT intron-variant
rs1000053703 -- 26,642,048(+) CGCAC(C/G)ACTGC upstream-variant-2KB
rs1000063551 -- 26,610,002(+) CATTC(A/G)CTCCT intron-variant
rs1000136483 -- 26,614,736(+) AGAGT(G/T)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIB4 Gene

Variant ID Type Subtype PubMed ID
esv2663963 CNV deletion 23128226
esv2719826 CNV deletion 23290073
esv33316 CNV loss 17666407
esv3554088 CNV deletion 23714750
esv3590124 CNV gain 21293372
esv3590125 CNV loss 21293372
nsv1072931 CNV deletion 25765185
nsv1149075 CNV deletion 26484159
nsv2651 CNV deletion 18451855
nsv517800 CNV loss 19592680
nsv955044 CNV deletion 24416366

Variation tolerance for CIB4 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIB4 Gene

Disorders for CIB4 Gene

Relevant External Links for CIB4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CIB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIB4 Gene

Publications for CIB4 Gene

  1. Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences. (PMID: 22779914) Huang H … Vogel HJ (Biochemistry and cell biology = Biochimie et biologie cellulaire 2012) 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. (PMID: 15574431) Gentry HR … Parise LV (The Journal of biological chemistry 2005) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for CIB4 Gene

  • Addgene plasmids for CIB4

Sources for CIB4 Gene

Loading form....