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Aliases for CIB3 Gene

Aliases for CIB3 Gene

  • Calcium And Integrin Binding Family Member 3 2 3
  • KIP3 3 4
  • DNA-Dependent Protein Kinase Catalytic Subunit-Interacting Protein 3 3
  • Kinase-Interacting Protein 3 4
  • KIP 3 4

External Ids for CIB3 Gene

Previous GeneCards Identifiers for CIB3 Gene

  • GC00U914336
  • GC19M016134
  • GC19M016272
  • GC19M015842

Summaries for CIB3 Gene

Entrez Gene Summary for CIB3 Gene

  • This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependent protein kinases. The exact function of this gene is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CIB3 Gene

CIB3 (Calcium And Integrin Binding Family Member 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIB3 Gene

Genomics for CIB3 Gene

Regulatory Elements for CIB3 Gene

Genomic Location for CIB3 Gene

16,161,368 bp from pter
16,173,525 bp from pter
12,158 bases
Minus strand

Genomic View for CIB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIB3 Gene

Proteins for CIB3 Gene

  • Protein details for CIB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium and integrin-binding family member 3
    Protein Accession:
    Secondary Accessions:
    • E7EUX1
    • Q2M1W0
    • Q6ISP1

    Protein attributes for CIB3 Gene

    187 amino acids
    Molecular mass:
    21802 Da
    Quaternary structure:
    • Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium and magnesium-dependent manner.
    • The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form)

    Alternative splice isoforms for CIB3 Gene


neXtProt entry for CIB3 Gene

Proteomics data for CIB3 Gene at MOPED

Post-translational modifications for CIB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIB3 Gene

No data available for DME Specific Peptides for CIB3 Gene

Domains & Families for CIB3 Gene

Gene Families for CIB3 Gene

Protein Domains for CIB3 Gene

Suggested Antigen Peptide Sequences for CIB3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EF-hand domains.
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with CIB3: view

Function for CIB3 Gene

Gene Ontology (GO) - Molecular Function for CIB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 22779914
GO:0005509 calcium ion binding IDA 22779914
GO:0005515 protein binding IPI 22779914
genes like me logo Genes that share ontologies with CIB3: view
genes like me logo Genes that share phenotypes with CIB3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIB3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CIB3 Gene

Localization for CIB3 Gene

Subcellular locations from

Jensen Localization Image for CIB3 Gene COMPARTMENTS Subcellular localization image for CIB3 gene
Compartment Confidence
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CIB3 Gene

Pathways & Interactions for CIB3 Gene

SuperPathways for CIB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIB3 Gene


No data available for Pathways by source and SIGNOR curated interactions for CIB3 Gene

Drugs & Compounds for CIB3 Gene

No Compound Related Data Available

Transcripts for CIB3 Gene

mRNA/cDNA for CIB3 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CIB3 Gene

Calcium and integrin binding family member 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIB3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIB3 Gene

No ASD Table

Relevant External Links for CIB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CIB3 Gene

mRNA expression in normal human tissues for CIB3 Gene

mRNA differential expression in normal tissues according to GTEx for CIB3 Gene

This gene is overexpressed in Testis (x27.7) and Whole Blood (x8.6).

SOURCE GeneReport for Unigene cluster for CIB3 Gene Hs.255432

genes like me logo Genes that share expression patterns with CIB3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CIB3 Gene

Orthologs for CIB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CIB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CIB3 35
  • 91.09 (n)
  • 97.86 (a)
CIB3 36
  • 98 (a)
(Canis familiaris)
Mammalia CIB3 35
  • 91.09 (n)
  • 97.86 (a)
CIB3 36
  • 98 (a)
(Mus musculus)
Mammalia Cib3 35
  • 85 (n)
  • 94.37 (a)
Cib3 16
Cib3 36
  • 94 (a)
(Pan troglodytes)
Mammalia CIB3 35
  • 98.75 (n)
  • 99.47 (a)
CIB3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cib3 35
  • 84.85 (n)
  • 93.05 (a)
(Monodelphis domestica)
Mammalia CIB3 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia CIB3 36
  • 84 (a)
(Gallus gallus)
Aves CIB3 35
  • 75.58 (n)
  • 82.89 (a)
CIB3 36
  • 79 (a)
(Anolis carolinensis)
Reptilia CIB3 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cib3 35
  • 73.15 (n)
  • 81.67 (a)
(Danio rerio)
Actinopterygii LOC100535603 35
  • 77.54 (n)
  • 82.35 (a)
CABZ01118627.1 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9236 36
  • 55 (a)
(Caenorhabditis elegans)
Secernentea calm-1 36
  • 46 (a)
Species with no ortholog for CIB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIB3 Gene

Gene Tree for CIB3 (if available)
Gene Tree for CIB3 (if available)

Paralogs for CIB3 Gene

Paralogs for CIB3 Gene

(7) SIMAP similar genes for CIB3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CIB3: view

Variants for CIB3 Gene

Sequence variations from dbSNP and Humsavar for CIB3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs285229 -- 16,161,923(+) caagc(C/G/T)atcca intron-variant
rs285230 -- 16,162,274(+) tttta(A/G)ttagc intron-variant
rs285231 -- 16,162,409(+) caaca(A/G)agtga intron-variant
rs285232 -- 16,162,480(+) ggcat(A/G)acggc intron-variant
rs285282 -- 16,169,856(+) gtgca(A/G)tggca intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CIB3 Gene

Variant ID Type Subtype PubMed ID
nsv833767 CNV Loss 17160897

Variation tolerance for CIB3 Gene

Residual Variation Intolerance Score: 51.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIB3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIB3 Gene

Disorders for CIB3 Gene

Relevant External Links for CIB3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CIB3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIB3 Gene

Publications for CIB3 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences. (PMID: 22779914) Huang H. … Vogel H.J. (Biochem. Cell Biol. 2012) 67
  3. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A. … Oetting W.S. (Transplantation 2010) 67
  4. Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. (PMID: 15574431) Gentry H.R. … Parise L.V. (J. Biol. Chem. 2005) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for CIB3 Gene

Sources for CIB3 Gene

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