Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CIB3 Gene

Aliases for CIB3 Gene

  • Calcium And Integrin Binding Family Member 3 2 3 5
  • KIP3 3 4
  • DNA-Dependent Protein Kinase Catalytic Subunit-Interacting Protein 3 3
  • Calcium And Integrin-Binding Family Member 3 3
  • Kinase-Interacting Protein 3 4
  • KIP 3 4

External Ids for CIB3 Gene

Previous GeneCards Identifiers for CIB3 Gene

  • GC00U914336
  • GC19M016134
  • GC19M016272
  • GC19M015842

Summaries for CIB3 Gene

Entrez Gene Summary for CIB3 Gene

  • This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependent protein kinases. The exact function of this gene is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CIB3 Gene

CIB3 (Calcium And Integrin Binding Family Member 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CIB2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIB3 Gene

Genomics for CIB3 Gene

Regulatory Elements for CIB3 Gene

Enhancers for CIB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F016148 1 Ensembl ENCODE 13.8 +23.9 23858 2.9 HDGF ATF1 ARNT ZFP64 NFXL1 ZNF143 ETV6 SMARCA5 ZNF280D MCM3 CIB3 FAM32A AP1M1 ENSG00000269243
GH19F016091 1 FANTOM5 ENCODE 12.1 +78.3 78267 7.6 ARID4B DMAP1 ZNF48 PAF1 ZNF263 SP5 KAT8 MBD2 SMARCA4 GLIS1 HSH2D CIB3 FAM32A C19orf44 EPS15L1 RAB8A ENSG00000267373 ENSG00000279198
GH19F016040 1.2 Ensembl ENCODE 11.8 +132.3 132324 1.6 ELF3 ARID4B ZNF48 RAD21 ZNF121 ZNF143 ZNF263 ZNF654 CEBPB MIER2 CIB3 FAM32A SNX33P1 AP1M1 OR10H4 OR10H5 LINC00905 PIR51994 OR1AB1P
GH19F016350 1.4 FANTOM5 Ensembl ENCODE 1.6 -178.1 -178076 1.6 BCOR TBP PKNOX1 ESRRA JUN ZMYM3 SIN3A MAX ZNF316 POLR2A KLF2 EPS15L1 ENSG00000269044 CIB3 ENSG00000277825
GH19F016172 1.1 Ensembl ENCODE 0.8 +0.3 333 1.6 BCOR CTCF ZMYM3 RAD21 GATA3 MTA3 CTBP1 POLR2A EED ZNF207 AP1M1 CIB3 ENSG00000269243
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CIB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CIB3 Gene

16,161,368 bp from pter
16,173,525 bp from pter
12,158 bases
Minus strand

Genomic View for CIB3 Gene

Genes around CIB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIB3 Gene

Proteins for CIB3 Gene

  • Protein details for CIB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium and integrin-binding family member 3
    Protein Accession:
    Secondary Accessions:
    • E7EUX1
    • Q2M1W0
    • Q6ISP1

    Protein attributes for CIB3 Gene

    187 amino acids
    Molecular mass:
    21802 Da
    Quaternary structure:
    • Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium and magnesium-dependent manner.
    • The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).

    Alternative splice isoforms for CIB3 Gene


neXtProt entry for CIB3 Gene

Post-translational modifications for CIB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIB3 Gene

No data available for DME Specific Peptides for CIB3 Gene

Domains & Families for CIB3 Gene

Gene Families for CIB3 Gene

Protein Domains for CIB3 Gene

Suggested Antigen Peptide Sequences for CIB3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EF-hand domains.
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with CIB3: view

Function for CIB3 Gene

Gene Ontology (GO) - Molecular Function for CIB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 22779914
GO:0005509 calcium ion binding IDA 22779914
GO:0005515 protein binding IPI 22779914
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CIB3: view
genes like me logo Genes that share phenotypes with CIB3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CIB3 Gene

Localization for CIB3 Gene

Subcellular locations from

Jensen Localization Image for CIB3 Gene COMPARTMENTS Subcellular localization image for CIB3 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
mitochondrion 2
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CIB3 Gene

Pathways & Interactions for CIB3 Gene

SuperPathways for CIB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIB3 Gene


No data available for Pathways by source and SIGNOR curated interactions for CIB3 Gene

Transcripts for CIB3 Gene

mRNA/cDNA for CIB3 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CIB3 Gene

Calcium and integrin binding family member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIB3 Gene

No ASD Table

Relevant External Links for CIB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CIB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CIB3 Gene

mRNA differential expression in normal tissues according to GTEx for CIB3 Gene

This gene is overexpressed in Testis (x27.7) and Whole Blood (x8.6).

NURSA nuclear receptor signaling pathways regulating expression of CIB3 Gene:


SOURCE GeneReport for Unigene cluster for CIB3 Gene:

genes like me logo Genes that share expression patterns with CIB3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CIB3 Gene

Orthologs for CIB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CIB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CIB3 34 35
  • 98.75 (n)
(Bos Taurus)
Mammalia CIB3 34 35
  • 91.09 (n)
(Canis familiaris)
Mammalia CIB3 34 35
  • 91.09 (n)
(Mus musculus)
Mammalia Cib3 34 16 35
  • 85 (n)
(Rattus norvegicus)
Mammalia Cib3 34
  • 84.85 (n)
(Ornithorhynchus anatinus)
Mammalia CIB3 35
  • 84 (a)
(Monodelphis domestica)
Mammalia CIB3 35
  • 72 (a)
(Gallus gallus)
Aves CIB3 34 35
  • 75.58 (n)
(Anolis carolinensis)
Reptilia CIB3 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cib3 34
  • 73.15 (n)
(Danio rerio)
Actinopterygii CABZ01118627.1 35
  • 82 (a)
LOC100535603 34
  • 77.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9236 35
  • 55 (a)
(Caenorhabditis elegans)
Secernentea calm-1 35
  • 46 (a)
Species where no ortholog for CIB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIB3 Gene

Gene Tree for CIB3 (if available)
Gene Tree for CIB3 (if available)

Paralogs for CIB3 Gene

Paralogs for CIB3 Gene

(7) SIMAP similar genes for CIB3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CIB3: view

Variants for CIB3 Gene

Sequence variations from dbSNP and Humsavar for CIB3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10405356 -- 16,168,442(+) ACAAC(C/T)CCACC intron-variant
rs10405936 -- 16,169,957(+) GCCAC(C/G)CCCGG intron-variant
rs10415138 -- 16,162,245(+) ccaca(A/C)aaaaa intron-variant
rs10420081 -- 16,163,204(+) ctgca(A/G)tgagc intron-variant
rs10421451 -- 16,163,185(+) tgagc(C/T)gagga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIB3 Gene

Variant ID Type Subtype PubMed ID
esv3643791 CNV loss 21293372
nsv833767 CNV loss 17160897

Variation tolerance for CIB3 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIB3 Gene

Disorders for CIB3 Gene

Relevant External Links for CIB3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CIB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIB3 Gene

Publications for CIB3 Gene

  1. Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences. (PMID: 22779914) Huang H. … Vogel H.J. (Biochem. Cell Biol. 2012) 3 4 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A. … Oetting W.S. (Transplantation 2010) 46 64
  4. Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. (PMID: 15574431) Gentry H.R. … Parise L.V. (J. Biol. Chem. 2005) 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for CIB3 Gene

Sources for CIB3 Gene

Loading form....