CIB3 Gene
protein-coding GIFtS: 40
GCID: GC19M016272
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calcium and integrin binding family member 3
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Aliases
for CIB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium And Integrin Binding Family Member 31 2 | | KIP31 2 3 | | Kinase-Interacting Protein 32 3 | | KIP 32 3 | | Calcium And Integrin-Binding Family Member 32 | | DNA-Dependent Protein Kinase Catalytic Subunit-Interacting Protein 32 |
Export aliases for CIB3 gene to outside databasesPrevious GC identifers: GC00U914336 GC19M016134 GC19M016135 GC19M015842 |
Summaries
for CIB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CIB3:
This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalyticsubunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependentprotein kinases. The exact function of this gene is not known. (provided by RefSeq, Jul 2008)
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Genomic Views
for CIB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CIB3 gene promoter:
ER-alpha RFX1 Pbx1a AML1a POU6F1 (c2) LUN-1 POU3F2 GATA-2 C/EBPalpha Pax-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CIB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.12 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.12CIB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M016272: view genomic region
(about GC identifiers)
Start:
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16,272,179 bp from pter |
End:
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16,284,286 bp from pter |
Size:
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12,108 bases |
Orientation:
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minus strand |
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Proteins
for CIB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CIB3_HUMAN, Q96Q77 (See
protein sequence)Recommended Name: Calcium and integrin-binding family member 3 Size: 187 amino acids; 21802 Da
Secondary accessions: Q2M1W0Explore the universe of human proteins at neXtProt for CIB3: NX_Q96Q77
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96Q77
CIB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_473454.1
ENSEMBL proteins: ENSP00000269878 ENSP00000369188 ENSP00000444490
Human Recombinant Protein Products for CIB3:
CIB3 Antibody Products:
Assay Products for CIB3: |
Protein
Domains /
Families
for CIB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CIB3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96Q77ProtoNet protein and cluster: Q96Q77 UniProtKB/Swiss-Prot: CIB3_HUMAN, Q96Q77Similarity: Contains 3 EF-hand domains |
Function
for CIB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- |
CIB3 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CIB3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CIB3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CIB3 (NM_054113) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CIB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIB3 |
|
Pathways & Interactions
for CIB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CIB3
|
Drugs & Compounds
for CIB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CIB3
Search CenterWatch for drugs/clinical trials and news about CIB3
|
Transcripts
for CIB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CIB3 gene: NM_054113.2 Unigene Cluster for CIB3: Calcium and integrin binding family member 3 Hs.255432 [show with all ESTs]Unigene Representative Sequence: BC1135913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000269878(uc002nds.3 uc010eae.3 uc010eaf.3 uc010eag.3)
ENST00000379859 ENST00000541493
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CIB3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CIB3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CIB3 (NM_054113) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CIB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIB3 |
Additional cDNA sequence: AB050868.1 BC069320.1 BC069428.1 BC069524.1 BC112200.1 BC113591.1 1 DOTS entry: DT.86847968 10 AceView cDNA sequences: AB050868 NM_054113 BC069524 BC069320 BC069428 AW295492 BG197284 BG217723 BG190679 BG193757
GeneLoc Exon Structure
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Expression
for CIB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CIB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATTTTAAC
About this image
See CIB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CIB3
SOURCE GeneReport for Unigene cluster: Hs.255432
SABiosciences Custom PCR Arrays for CIB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CIB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CIB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIB3 |
Orthologs
for CIB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CIB3 gene from 8/20 species (see all 20) About this table
ENSEMBL Gene Tree for CIB3 (if available)
TreeFam Gene Tree for CIB3 (if available) |
Paralogs
for CIB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CIB3 gene
- CIB12 PPP3R22 CIB42 PPP3R12 WDR922 CHP22 TESC2 CIB22
- CHP12
7 SIMAP similar genes for CIB3 using alignment to 6 protein entries: CIB3_HUMAN (see all proteins):CIB2 CIB1 CIB4 PPP3R1 CALM3 HZGJ
PPP3R2
CIB3 for paralogs About GeneDecksing
|
Genomic Variants
for CIB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CIB3 (16272179 - 16284286 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CIB3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CIB3 |
|
Disorders
/ Diseases
for CIB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CIB3 for disorders About MalaCards
CIB3 for disorders About GeneDecksing
OMIM gene information: 610645
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: CIB3 (1 document)
Export disorders for CIB3 gene to outside databases
|
Publications
for CIB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CIB3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CIB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Biophysical and structural studies of the human calciu m- and integrin-binding protein family: understanding their functional similarit ies and differences. (PubMed id 22779914)1 Huang H....Vogel H.J. (2012)
- Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. (PubMed id 15574431)1 Gentry H.R....Parise L.V. (2005)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for CIB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CIB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CIB3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CIB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CIB3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CIB3 gene:
Search GeneIP for patents involving CIB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CIB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CIB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CIB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CIB3 | | | OriGene Protein Over-expression Lysate for CIB3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CIB3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CIB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CIB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CIB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CIB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CIB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIB3 |
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 | | | CIB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIB3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CIB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIB3 |
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