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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CIB2 Gene

protein-coding   GIFtS: 52
GCID: GC15M078396

calcium and integrin binding family member 2

(Previous names: deafness, autosomal recessive 48, Usher syndrome 1J (autosomal...)
(Previous symbols: DFNB48, USH1J)
 Explore 3 diseases affiliated with
CIB2 via our new
 Human Malady Compendium 
Biological research products
for CIB2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Calcium And Integrin Binding Family Member 21 2     Deafness, Autosomal Recessive 481
KIP21 2 3 5     2810434I23Rik2
DFNB481 2     Calcium And Integrin-Binding Family Member 22
USH1J1 2     DNA-Dependent Protein Kinase Catalytic Subunit-Interacting Protein 22
Usher Syndrome 1J (Autosomal Recessive)1 2     Kinase-Interacting Protein 23
KIP 22 3     

External Ids:    HGNC: 245791   Entrez Gene: 105182   Ensembl: ENSG000001364257   OMIM: 6055645   UniProtKB: O758383   

Export aliases for CIB2 gene to outside databases

Previous GC identifers: GC15M076113 GC15M076184 GC15M055154


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CIB2:
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. This suggests that the
encoded protein may be a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic
subunits (DNA-PKcs). Several transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838
Function: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and
participate in calcium regulation in the mechanotransduction process (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CIB2 gene promoter:
         GCNF   AP-2gamma   E47   YY1   CREB   GCNF-1   deltaCREB   Hand1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCIB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CIB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q24

CIB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIB2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M078396:  view genomic region     (about GC identifiers)

Start:
78,396,948 bp from pter      End:
78,423,886 bp from pter
Size:
26,939 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838 (See protein sequence)
Recommended Name: Calcium and integrin-binding family member 2  
Size: 187 amino acids; 21644 Da
Subcellular location: Photoreceptor inner segment (By similarity). Note=Expressed in inner and outer segments of
photoreceptor cells, as well as in the pigmented epithelium. Also observed in the inner and outer plexiform layers and
in the ganglion cell layer (By similarity)

Explore the universe of human proteins at neXtProt for CIB2: NX_O75838

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75838

  • CIB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258817.1  NP_001258818.1  NP_006374.1  

    ENSEMBL proteins: 
     ENSP00000258930   ENSP00000442459   ENSP00000453488   ENSP00000453654   ENSP00000453963  
     ENSP00000453256   ENSP00000452752   ENSP00000452980   ENSP00000453377  

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    Uscn Proteins for CIB2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001917photoreceptor inner segment ISS--


    CIB2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CIB2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry O75838

    ProtoNet protein and cluster: O75838

    UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838
    Similarity: Contains 3 EF-hand domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838
    Function: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and
    participate in calcium regulation in the mechanotransduction process (By similarity)

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    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--


    CIB2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CIB2:
     Decreased viability  Metaphase cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CIB2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CIB2 (O758383 ENSP000002589304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOD1P151723, ENSP000002500034I2D: score=1 STRING: ENSP00000250003
    C3AR1ENSP000003020794STRING: ENSP00000302079
    CHRM4ENSP000004093784STRING: ENSP00000409378
    DRD5ENSP000003061294STRING: ENSP00000306129
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007229integrin-mediated signaling pathway ----
    GO:0045494photoreceptor cell maintenance ISS--
    GO:0055074calcium ion homeostasis ISS--


    CIB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CIB2 gene (3 alternative transcripts): 
    NM_001271888.1  NM_001271889.1  NM_006383.3  

    Unigene Cluster for CIB2:

    Calcium and integrin binding family member 2
    Hs.129867  [show with all ESTs]
    Unigene Representative Sequence: NM_006383
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258930(uc002bdb.1 uc002bdc.1 uc010ums.1) ENST00000539011
    ENST00000557846 ENST00000557818 ENST00000557917 ENST00000561190 ENST00000560618
    ENST00000559645 ENST00000559054

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    hsa-miR-448 hsa-miR-130a* hsa-miR-23c hsa-miR-488 hsa-miR-1233 hsa-miR-153 hsa-miR-23b hsa-miR-129-5p
    SwitchGear 3'UTR luciferase reporter plasmidCIB2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB012955.1 AL110098.1 BC020443.1 BC033108.1 BC047381.1 BC057292.1 BT019962.1 

    9 DOTS entries:

    DT.101983174  DT.213037  DT.95260983  DT.95266788  DT.100752024  DT.97823015  DT.100021102  DT.92423718 
    DT.95266787 

    24/109 AceView cDNA sequences (see all 109):

    AI571206 AA988533 BM803930 AI417406 BE220389 AI364119 BC020443 BX280035 
    AI827068 BE220454 AI128397 AW406244 BF732986 AW162267 NM_006383 BE042882 
    AI216148 AI423053 BU556614 BM551089 BM684896 BC047381 BF436673 BU541041 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CIB2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                          -     -     -                       -               
    SP2:                                -     -                       -               
    SP3:        -                 -     -     -                                       
    SP4:        -     -     -     -     -     -                       -               
    SP5:              -     -     -     -                                             


    ECgene alternative splicing isoforms for CIB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CIB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTACCACCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CIB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbHindlimb Ventral MuscleLimb
    Skeletal MuscleMandibular Arch MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)

    See CIB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CIB2

    SOURCE GeneReport for Unigene cluster: Hs.129867

    UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CIB2 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CIB21 calcium and integrin binding family member 2 71.66(n)
    78.61(a)
      415363  XM_413749.3  XP_413749.1 
    lizard
    (Anolis carolinensis)
    Reptilia CIB26
    --
    73(a)
    1 ↔ 1
    GL344373.1(250-15572)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc730792 hypothetical protein MGC73079 74.32(n)   393679  BC059451.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92361 CG9236 60.25(n)
    59.89(a)
      37363  NM_137679.3  NP_611523.3 
    worm
    (Caenorhabditis elegans)
    Secernentea calm-11 Protein CALM-1 53.33(n)
    51.89(a)
      172774  NM_060113.2  NP_492514.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G184306
    EF-hand, calcium binding motif-containing protein
    23(a)
    1 → many
    3(6325915-6327692)
    rice
    (Oryza sativa)
    Liliopsida --
    EF hand family protein, putative, expressed
    25(a)
    1 → many
    2(34200999-34203985)


    ENSEMBL Gene Tree for CIB2 (if available)
    TreeFam Gene Tree for CIB2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CIB2 gene
    CIB12  CIB32  PPP3R22  CIB42  PPP3R12  WDR922  CHP22  TESC2  
    CHP12  
    7 SIMAP similar genes for CIB2 using alignment to 10 protein entries:     CIB2_HUMAN (see all proteins):
    CIB3    CIB1    CIB4    PPP3R1    PPP3R2    HZGJ
    CALM3

    CIB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/541 NCBI SNPs in CIB2 are shown (see all 541    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1141822381,2
    F,--78396591(+) TGCCCC/TTCCTC 2 -- ds5001 int11Minor allele frequency- T:0.04WA 118
    rs1475836131,2
    --78396771(+) AGCACG/TCCCAA 2 -- ds5001 int10--------
    rs786759461,2
    C,F,--78396777(+) CCCAAA/GTGTTA 2 -- int1 ds50011Minor allele frequency- G:0.06EA 120
    rs1420380141,2
    --78396839(+) TTCCTC/GCCGAT 2 -- ds5001 int10--------
    rs115472081,2
    C--78397068(-) TGCCTC/ACCCAA 1 -- ut31 ese31Minor allele frequency- A:0.00NA 2
    rs113418561,2
    C,--78397350(+) CCCTC-/TTTGGG 1 -- ut31 trp33Minor allele frequency- T:0.00NA CSA 6
    rs1130612651,2
    C--78397352(+) CTCTTG/TGGGGG 1 -- ut311Minor allele frequency- T:0.00CSA 1
    rs346657551,2
    C--78397358(+) GGGGGG/AGTGGG 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1837640481,2
    --78397409(+) GGTGCA/GGAGGG 1 -- ut310--------
    rs1896161341,2
    --78397437(+) GGTCCC/TGGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CIB2 (78396948 - 78423886 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CIB2
         2 Indels: 11803 11802
    Human Gene Mutation Database (HGMD): CIB2

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CIB2 for disorders           About GeneDecksing

    OMIM gene information: 605564    OMIM disorders: --

    UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838
  • Defects in CIB2 are the cause of deafness, autosomal recessive, 48 (DFNB48) [MIM:609439]. A form of
  • non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the
    inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB48 patients
    have prelingual onset of severe to profound sensorineural hearing loss affecting all frequencies
  • Defects in CIB2 are the cause of Usher syndrome 1J (USH1J) [MIM:614869]. USH is a genetically heterogeneous
  • condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and
    differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2)
    and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent
    vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness

    3 diseases for CIB2:    About MalaCards
    overgrowth syndrome    keratoconus    cataract


    Export disorders for CIB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CIB2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CIB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, expression profile and chromosomal location of an isolog of DNA-PKcs interacting protein (KIP) gene. (PubMed id 9931475)1, 2, 3, 9 Seki N....Saito T. (1999)
    2. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. (PubMed id 23023331)1, 2, 3 Riazuddin S.... Ahmed Z.M. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Biophysical and structural studies of the human calciu m- and integrin-binding protein family: understanding their functional similarit ies and differences. (PubMed id 22779914)1 Huang H....Vogel H.J. (2012)
    5. DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1. (PubMed id 15711797)1 Ahmad J....Riazuddin S. (2005)
    6. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Stabilization of MyoD by direct binding to p57(Kip2). (PubMed id 10764802)1 Reynaud E.G....Leibovitch S.A. (2000)
    9. Overgrowth syndromes and genomic imprinting: from mouse to man. (PubMed id 9630066)1 Li M....Weksberg R. (1998)
    10. Fine mapping of the keratoconus with cataract locus on chromosome 15q and candidate gene analysis. (PubMed id 16735990)9 Dash D.P....Hughes A.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10518 HGNC: 24579 AceView: CIB2 Ensembl:ENSG00000136425 euGenes: HUgn10518
    ECgene: CIB2 H-InvDB: CIB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CIB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CIB2 gene:
    Search GeneIP for patents involving CIB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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