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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CIB2 Gene

protein-coding   GIFtS: 54
GCID: GC15M078396

Calcium And Integrin Binding Family Member 2

(Previous names: deafness, autosomal recessive 48, Usher syndrome 1J (autosomal...)
(Previous symbols: DFNB48, USH1J)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium And Integrin Binding Family Member 21 2     Deafness, Autosomal Recessive 481
KIP22 3 5     2810434I23Rik2
DFNB481 2     Calcium And Integrin-Binding Family Member 22
USH1J1 2     DNA-Dependent Protein Kinase Catalytic Subunit-Interacting Protein 22
Usher Syndrome 1J (Autosomal Recessive)1 2     Kinase-Interacting Protein 23
KIP 22 3     

External Ids:    HGNC: 245791   Entrez Gene: 105182   Ensembl: ENSG000001364257   OMIM: 6055645   UniProtKB: O758383   

Export aliases for CIB2 gene to outside databases

Previous GC identifers: GC15M076113 GC15M076184 GC15M055154


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CIB2 Gene:
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. This suggests that
the encoded protein may be a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase
catalytic subunits (DNA-PKcs). Several transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Dec 2012)

GeneCards Summary for CIB2 Gene: 
CIB2 (calcium and integrin binding family member 2) is a protein-coding gene. Diseases associated with CIB2 include usher syndrome 1j, and deafness, autosomal recessive, 48. GO annotations related to this gene include protein binding and calcium ion binding. An important paralog of this gene is CIB1.

UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838
Function: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis
and participate in calcium regulation in the mechanotransduction process (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CIB2 gene promoter:
         GCNF   AP-2gamma   E47   YY1   CREB   GCNF-1   deltaCREB   Hand1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCIB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CIB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q24

CIB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIB2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M078396:  view genomic region     (about GC identifiers)

Start:
78,396,948 bp from pter      End:
78,423,886 bp from pter
Size:
26,939 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838 (See protein sequence)
Recommended Name: Calcium and integrin-binding family member 2  
Size: 187 amino acids; 21644 Da
Subcellular location: Photoreceptor inner segment (By similarity). Note=Expressed in inner and outer segments of
photoreceptor cells, as well as in the pigmented epithelium. Also observed in the inner and outer plexiform
layers and in the ganglion cell layer (By similarity)

Explore the universe of human proteins at neXtProt for CIB2: NX_O75838

Explore proteomics data for CIB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75838

  • CIB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CIB2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001258817.1  NP_001258818.1  NP_006374.1  

    ENSEMBL proteins: 
     ENSP00000258930   ENSP00000442459   ENSP00000453488   ENSP00000453654   ENSP00000453963  
     ENSP00000453256   ENSP00000452752   ENSP00000452980   ENSP00000453377  

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    Sino Biological Recombinant Protein for CIB2
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    Cloud-Clone Corp. Proteins for CIB2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001917photoreceptor inner segment ISS--

    CIB2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry O75838

    ProtoNet protein and cluster: O75838

    UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838
    Similarity: Contains 3 EF-hand domains


    CIB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIB2_HUMAN, O75838
    Function: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis
    and participate in calcium regulation in the mechanotransduction process (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    CIB2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CIB2:
     Decreased viability  Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CIB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CIB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIB2 

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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CIB2 (see all 13):
    hsa-miR-448 hsa-miR-130a* hsa-miR-23c hsa-miR-488 hsa-miR-1233 hsa-miR-153 hsa-miR-23b hsa-miR-129-5p
    SwitchGear 3'UTR luciferase reporter plasmidCIB2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CIB2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CIB2 (O758383 ENSP000002589304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOD1P151723, ENSP000002500034I2D: score=1 STRING: ENSP00000250003
    C3AR1ENSP000003020794STRING: ENSP00000302079
    CHRM4ENSP000004093784STRING: ENSP00000409378
    DRD5ENSP000003061294STRING: ENSP00000306129
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007229integrin-mediated signaling pathway ----
    GO:0045494photoreceptor cell maintenance ISS--
    GO:0055074calcium ion homeostasis ISS--

    CIB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CIB2

    Search CenterWatch for drugs/clinical trials and news about CIB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CIB2 gene (3 alternative transcripts): 
    NM_001271888.1  NM_001271889.1  NM_006383.3  

    Unigene Cluster for CIB2:

    Calcium and integrin binding family member 2
    Hs.129867  [show with all ESTs]
    Unigene Representative Sequence: NM_006383
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258930(uc002bdb.1 uc002bdc.1 uc010ums.1) ENST00000539011
    ENST00000557846 ENST00000557818 ENST00000557917 ENST00000561190 ENST00000560618
    ENST00000559645 ENST00000559054
    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CIB2 (see all 13):
    hsa-miR-448 hsa-miR-130a* hsa-miR-23c hsa-miR-488 hsa-miR-1233 hsa-miR-153 hsa-miR-23b hsa-miR-129-5p
    SwitchGear 3'UTR luciferase reporter plasmidCIB2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AB012955.1 AL110098.1 BC020443.1 BC033108.1 BC047381.1 BC057292.1 BT019962.1 

    9 DOTS entries:

    DT.101983174  DT.213037  DT.95260983  DT.95266788  DT.100752024  DT.97823015  DT.100021102  DT.92423718 
    DT.95266787 

    24/109 AceView cDNA sequences (see all 109):

    BE042882 AW406244 AI128397 BC020443 AI827068 BE220454 AI417406 BX280035 
    BE220389 AI364119 AI423053 AW162267 AA988533 NM_006383 BU556614 AI571206 
    BF732986 BM803930 AI216148 BM551089 BM684896 AB012955 AI970830 AI186486 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CIB2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                          -     -     -                       -               
    SP2:                                -     -                       -               
    SP3:        -                 -     -     -                                       
    SP4:        -     -     -     -     -     -                       -               
    SP5:              -     -     -     -                                             


    ECgene alternative splicing isoforms for CIB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CIB2 expression in normal human tissues (normalized intensities)      CIB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTACCACCC
    CIB2 Expression
    About this image


    CIB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)
             Mandibular Arch Muscles
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Testis (Reproductive System)
             sperm   
     
     Limb (Muscoskeletal System)
             Hindlimb Ventral Muscle
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus

    See CIB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CIB2

    SOURCE GeneReport for Unigene cluster: Hs.129867

    UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CIB2 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cib21 , 5 calcium and integrin binding family member 21, 5 90.2(n)1
    97.33(a)1
      9 (29.70 cM)5
    565061  NM_019686.51  NP_062660.11 
     545447945 
    chicken
    (Gallus gallus)
    Aves CIB21 calcium and integrin binding family member 2 71.66(n)
    78.61(a)
      415363  XM_413749.3  XP_413749.1 
    lizard
    (Anolis carolinensis)
    Reptilia CIB26
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL344373.1(250-15572)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc730792 hypothetical protein MGC73079 74.32(n)   393679  BC059451.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92361 CG9236 60.25(n)
    59.89(a)
      37363  NM_137679.3  NP_611523.3 
    worm
    (Caenorhabditis elegans)
    Secernentea calm-11 Protein CALM-1 53.33(n)
    51.89(a)
      172774  NM_060113.2  NP_492514.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CNB16
    Calcineurin B; the regulatory subunit of calcineur...
    26(a)
    1 → many
    XI(82947-83550)


    ENSEMBL Gene Tree for CIB2 (if available)
    TreeFam Gene Tree for CIB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CIB2 gene
    CIB12  CIB32  CIB42  
    8 SIMAP similar genes for CIB2 using alignment to 10 protein entries:     CIB2_HUMAN (see all proteins):
    CIB3    CIB1    CIB4    PPP3R1    PPP3R2    CALM3
    HZGJ    CALM2

    CIB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/621 SNPs in CIB2 are shown (see all 621)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0690884
    Deafness, autosomal recessive, 48 (DFNB48)4--see VAR_0690882 C W mis40--------
    VAR_0690874
    Deafness, autosomal recessive, 48 (DFNB48)4--see VAR_0690872 F S mis40--------
    VAR_0690894
    Deafness, autosomal recessive, 48 (DFNB48)4--see VAR_0690892 I T mis40--------
    VAR_0690864
    Usher syndrome 1J (USH1J)4--see VAR_0690862 E D mis40--------
    rs2011932231,2
    C--55159096(+) CCCCA-/CCCCGCA 3 -- int10--------
    rs1487096041,2
    C--55160770(+) AGACA-/CAGGTCTG
    CCAACTACAG
    CAGGC
    3 -- int10--------
    rs2007501261,2
    C--55166858(+) GAACC-/A/AA  
            
    AAAAA
    3 -- int10--------
    rs1451704381,2
    --58435477(+) GTCCCC/TTTCTC 3 -- ds5001 int10--------
    rs1141822381,2
    C,F--58435587(+) TGCCCC/TTCCTC 3 -- ds5001 int11Minor allele frequency- T:0.04WA 118
    rs1475836131,2
    C--58435767(+) AGCACG/TCCCAA 3 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for CIB2 (78396948 - 78423886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CIB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv94621CNV Loss16902084
    nsv526717CNV Loss19592680
    nsv94529CNV Loss16902084
    esv274890CNV Gain+Loss21479260


    Human Gene Mutation Database (HGMD): CIB2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605564    OMIM disorders: --

    UniProtKB/Swiss-Prot: CIB2_HUMAN, O75838
  • Deafness, autosomal recessive, 48 (DFNB48) [MIM:609439]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. DFNB48 patients have prelingual onset of
    severe to profound sensorineural hearing loss affecting all frequencies. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Usher syndrome 1J (USH1J) [MIM:614869]: USH is a genetically heterogeneous condition characterized by the
    association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and
    vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome
    type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function
    and prepubertal onset of progressive retinitis pigmentosa leading to blindness. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 12 diseases for CIB2:    About MalaCards
    usher syndrome 1j    deafness, autosomal recessive, 48    usher syndrome type i    usher syndrome type 3
    usher syndrome    keratoconus    nonsyndromic deafness    sensorineural hearing loss
    cataract    retinitis pigmentosa    blindness    retinitis


    CIB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CIB2

    Export disorders for CIB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CIB2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CIB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, expression profile and chromosomal location of an isolog of DNA-PKcs interacting protein (KIP) gene. (PubMed id 9931475)1, 2, 3, 9 Seki N....Saito T. (1999)
    2. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. (PubMed id 23023331)1, 2, 3 Riazuddin S.... Ahmed Z.M. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Biophysical and structural studies of the human calciu m- and integrin-binding protein family: understanding their functional similarit ies and differences. (PubMed id 22779914)1 Huang H....Vogel H.J. (2012)
    5. DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1. (PubMed id 15711797)1 Ahmad J....Riazuddin S. (2005)
    6. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Stabilization of MyoD by direct binding to p57(Kip2). (PubMed id 10764802)1 Reynaud E.G....Leibovitch S.A. (2000)
    9. Overgrowth syndromes and genomic imprinting: from mouse to man. (PubMed id 9630066)1 Li M....Weksberg R. (1998)
    10. Fine mapping of the keratoconus with cataract locus on chromosome 15q and candidate gene analysis. (PubMed id 16735990)9 Dash D.P....Hughes A.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10518 HGNC: 24579 AceView: CIB2 Ensembl:ENSG00000136425 euGenes: HUgn10518
    ECgene: CIB2 H-InvDB: CIB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CIB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CIB2 gene:
    Search GeneIP for patents involving CIB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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