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Aliases for CIB1 Gene

Aliases for CIB1 Gene

  • Calcium And Integrin Binding 1 (Calmyrin) 2 3
  • CIB 3 4 6
  • DNA-PKcs-Interacting Protein 3 4
  • SNK-Interacting Protein 2-28 3 4
  • PRKDCIP 3 4
  • SIP2-28 3 4
  • CIBP 3 4
  • KIP 4 6
  • DNA-Dependent Protein Kinase Interacting Protein 3
  • Calcium And Integrin-Binding Protein 1 3
  • Calcium- And Integrin-Binding Protein 4
  • DNA-PK Interaction Protein 3
  • Kinase-Interacting Protein 4
  • Calmyrin 4
  • KIP1 3

External Ids for CIB1 Gene

Summaries for CIB1 Gene

Entrez Gene Summary for CIB1 Gene

  • This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

GeneCards Summary for CIB1 Gene

CIB1 (Calcium And Integrin Binding 1 (Calmyrin)) is a Protein Coding gene. Among its related pathways are Development Angiotensin activation of ERK. GO annotations related to this gene include calcium ion binding and protein anchor. An important paralog of this gene is CHP1.

UniProtKB/Swiss-Prot for CIB1 Gene

  • Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells

  • Isoform 2: Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion.

Gene Wiki entry for CIB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIB1 Gene

Genomics for CIB1 Gene

Genomic Location for CIB1 Gene

Start:
90,229,975 bp from pter
End:
90,265,759 bp from pter
Size:
35,785 bases
Orientation:
Minus strand

Genomic View for CIB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIB1 Gene

Regulatory Elements for CIB1 Gene

Proteins for CIB1 Gene

  • Protein details for CIB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99828-CIB1_HUMAN
    Recommended name:
    Calcium and integrin-binding protein 1
    Protein Accession:
    Q99828
    Secondary Accessions:
    • B5BU40
    • H6WJF3
    • O00693
    • O00735
    • Q6IB49
    • Q96J54
    • Q99971

    Protein attributes for CIB1 Gene

    Size:
    191 amino acids
    Molecular mass:
    21703 Da
    Quaternary structure:
    • Monomer. Interacts with MYO1C. Interacts (via C-terminal region) with PPP3R1 and CACNA1C; the interactions increase upon cardiomyocytes hypertrophy (By similarity). Interacts with the heterodimeric integrin alpha-IIb/beta3 (ITGA2B-ITGB3). Interacts with ITGA2B (via cytoplasmic domain); the interaction is direct and calcium-dependent. Interacts with the protein kinases PLK2/SNK and PRKDC (via the region immediately upstream of the kinase domain). Interacts with PLK3; the interaction inhibits PLK3 kinase activity. Interacts with PSEN2. Interacts (via C-terminus) with F8. Interacts with NBR1 (via C-terminus). Interacts with FEZ1 (via C-terminus). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation. Interacts with IFI6. Interacts with BCL2. Interacts with ITPR3; the interaction occurs in a calcium-dependent manner. Interacts with PTK2/FAK1. Interacts with MAP3K5; the interaction inhibits MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2. Isoform 2 interacts with PRKD2 (via N-terminal AP-rich region), PTK2/FAK1 and PAK1. Interacts with TAS1R2 (via C-terminus); the interaction is independent of the myristoylation state of CIB1. Interacts (via C-terminal region) with STMN2 (via the N-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the STMN2-induced neurite outgrowth inhibition. Interacts with SPHK1, the interaction occurs in a calcium-dependent manner. Interacts with ITGA2B (via C-terminal cytoplasmic tail); the interaction occurs upon platelet aggregation and is stabilized/increased in a calcium and magnesium-dependent manner. Interacts with PAK1 (via N-terminal region); the interaction is direct and occurs in a calcium-dependent manner. Interacts with RAC3 (via C-terminal region); the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion. Interacts with ITGA5 and ITGAV.
    Miscellaneous:
    • The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).

    Three dimensional structures from OCA and Proteopedia for CIB1 Gene

    Alternative splice isoforms for CIB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIB1 Gene

Proteomics data for CIB1 Gene at MOPED

Post-translational modifications for CIB1 Gene

  • Phosphorylation of isoform 2 at Ser-78 by PRKD2 increases its ability to stimulate tumor angiogenesis.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys10, Lys24, Lys65, and Lys70

Other Protein References for CIB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CIB1 Gene

Domains for CIB1 Gene

Gene Families for CIB1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for CIB1 Gene

UniProtKB/Swiss-Prot:

CIB1_HUMAN
Domain:
  • The EF-hands may also bind magnesium ions in the presence of high Mg(2+) levels and low Ca(2+) levels:
    • Q99828
  • Contains 2 EF-hand domains.:
    • Q99828
genes like me logo Genes that share domains with CIB1: view

Function for CIB1 Gene

Molecular function for CIB1 Gene

UniProtKB/Swiss-Prot Function: Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells
UniProtKB/Swiss-Prot Function: Isoform 2: Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion.
UniProtKB/Swiss-Prot Induction: Up-regulated during breast cancer progression

Gene Ontology (GO) - Molecular Function for CIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IMP 15475008
GO:0005515 protein binding IPI 10366599
GO:0008427 calcium-dependent protein kinase inhibitor activity IMP 20473878
GO:0017016 Ras GTPase binding IPI 11756406
GO:0030291 protein serine/threonine kinase inhibitor activity IDA 20473878
genes like me logo Genes that share ontologies with CIB1: view
genes like me logo Genes that share phenotypes with CIB1: view

Animal Models for CIB1 Gene

MGI Knock Outs for CIB1:

miRNA for CIB1 Gene

miRTarBase miRNAs that target CIB1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CIB1 Gene

Localization for CIB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIB1 Gene

Membrane; Lipid-anchor. Cell membrane, sarcolemma. Cell membrane. Apical cell membrane. Cell projection, ruffle membrane. Cell projection, filopodium tip. Cell projection, growth cone. Cell projection, lamellipodium. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart (By similarity). Colocalized with NBR1 to the perinuclear region. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with STMN2 in the cell body, neurites and growth cones of neurons. Colocalized with STMN2 to the leading edge of lamellipodia. Colocalized with PLK3 at centrosomes in ductal breast carcinoma cells. {ECO:0000250}.
Isoform 2: Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIB1 Gene COMPARTMENTS Subcellular localization image for CIB1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
endoplasmic reticulum 3
cytosol 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11756406
GO:0005654 nucleoplasm IMP 10366599
GO:0005737 cytoplasm IMP 10366599
GO:0005783 endoplasmic reticulum IMP 10366599
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with CIB1: view

Pathways for CIB1 Gene

genes like me logo Genes that share pathways with CIB1: view

Pathways by source for CIB1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CIB1 Gene

Gene Ontology (GO) - Biological Process for CIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0001954 positive regulation of cell-matrix adhesion ISS --
GO:0002931 response to ischemia ISS --
genes like me logo Genes that share ontologies with CIB1: view

Compounds for CIB1 Gene

(8) Novoseek inferred chemical compound relationships for CIB1 Gene

Compound -log(P) Hits PubMed IDs
calcium 36.7 29
fibrinogen 30.1 6
threonine 26.4 2
leucine 18.6 1
serine 18 2
genes like me logo Genes that share compounds with CIB1: view

Transcripts for CIB1 Gene

Unigene Clusters for CIB1 Gene

Calcium and integrin binding 1 (calmyrin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CIB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d · 8e
SP1: - - -
SP2: - - - -
SP3:
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - -
SP8: -
SP9:
SP10:
SP11:
SP12: -

Relevant External Links for CIB1 Gene

GeneLoc Exon Structure for
CIB1
ECgene alternative splicing isoforms for
CIB1

Expression for CIB1 Gene

mRNA expression in normal human tissues for CIB1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CIB1 Gene

SOURCE GeneReport for Unigene cluster for CIB1 Gene Hs.715556

mRNA Expression by UniProt/SwissProt for CIB1 Gene

Q99828-CIB1_HUMAN
Tissue specificity: Detected in platelets and in cell lines of megakaryocytic and erythrocytic lineages. Both isoform 1 and isoform 2 are detected in various cancer cell lines, with isoform 2 being the predominant form (at protein level). Ubiquitously expressed.
genes like me logo Genes that share expressions with CIB1: view

Orthologs for CIB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CIB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIB1 36
  • 99.65 (n)
  • 100 (a)
CIB1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CIB1 36
  • 91.45 (n)
  • 94.24 (a)
CIB1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIB1 36
  • 91.62 (n)
  • 94.24 (a)
CIB1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cib1 36
  • 89.18 (n)
  • 93.72 (a)
Cib1 16
Cib1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CIB1 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cib1 36
  • 89.88 (n)
  • 93.72 (a)
chicken
(Gallus gallus)
Aves CIB1 36
  • 75.49 (n)
  • 74.6 (a)
CIB1 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13909 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cib1 36
  • 64.73 (n)
  • 69.31 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2005 36
zebrafish
(Danio rerio)
Actinopterygii cib1 37
  • 74 (a)
OneToOne
LOC100536377 36
  • 68.45 (n)
  • 74.87 (a)
wufc44f06 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008474 36
  • 52.61 (n)
  • 47.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32812 37
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 37
  • 27 (a)
OneToMany
Species with no ortholog for CIB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIB1 Gene

ENSEMBL:
Gene Tree for CIB1 (if available)
TreeFam:
Gene Tree for CIB1 (if available)

Paralogs for CIB1 Gene

Paralogs for CIB1 Gene

Selected SIMAP similar genes for CIB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CIB1: view

Variants for CIB1 Gene

Sequence variations from dbSNP and Humsavar for CIB1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3932 -- 90,245,676(-) CTTTG(A/G)ACGCA intron-variant
rs1044813 -- 90,231,027(-) CCTTT(C/G)CCAGA intron-variant
rs1139752 -- 90,232,252(-) GTGCC(C/T)TTCGA reference, synonymous-codon, nc-transcript-variant
rs1139757 -- 90,231,461(-) ATCCC(A/C)AGCCA missense, reference, nc-transcript-variant
rs1804798 -- 90,231,434(-) TGAGG(A/G)CTTCC reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CIB1 Gene

Variant ID Type Subtype PubMed ID
dgv776e1 CNV Complex 17122850
dgv112e55 CNV Gain 17911159
dgv777e1 CNV Complex 17122850
nsv442384 CNV CNV 18776908
nsv817707 CNV Gain 17921354
dgv2435n71 CNV Loss 21882294
nsv904491 CNV Loss 21882294
nsv833087 CNV Loss 17160897

Relevant External Links for CIB1 Gene

HapMap Linkage Disequilibrium report
CIB1

Disorders for CIB1 Gene

(6) Novoseek inferred disease relationships for CIB1 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 14.6 1
gastric cancer 12.7 2
breast cancer 0 1
metastasis 0 1
tumors 0 4

Relevant External Links for CIB1

Genetic Association Database (GAD)
CIB1
Human Genome Epidemiology (HuGE) Navigator
CIB1
genes like me logo Genes that share disorders with CIB1: view

No data available for UniProtKB/Swiss-Prot for CIB1 Gene

Publications for CIB1 Gene

  1. Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP). (PMID: 10826701) Hattori A. … Saito T. (DNA Seq. 2000) 2 3 4 23
  2. The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. (PMID: 11756406) Haataja L. … Heisterkamp N. (J. Biol. Chem. 2002) 3 4 23
  3. Interaction between DNA-dependent protein kinase and a novel protein, KIP. (PMID: 9372844) Wu X. … Lieber M.R. (Mutat. Res. 1997) 3 4 23
  4. Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies. (PMID: 10822252) Hwang P.M. … Vogel H.J. (J. Mol. Recognit. 2000) 3 4 23
  5. Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain. (PMID: 12023286) Barry W.T. … Parise L.V. (J. Biol. Chem. 2002) 3 4 23

Products for CIB1 Gene

  • Addgene plasmids for CIB1

Sources for CIB1 Gene

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