CIB1 Gene
protein-coding GIFtS: 57
GCID: GC15M090773
|
|
calcium and integrin binding 1 (calmyrin)
| |
Aliases
for CIB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium And Integrin Binding 1 (Calmyrin)1 2 | | KIP12 | | CIB1 2 3 5 | | Calcium And Integrin Binding Protein 12 | | KIP1 2 3 5 | | Calcium And Integrin Binding, Protein Kinase Interacting Protein2 | | SIP2-281 2 3 | | Calcium And Integrin-Binding Protein 12 | | Calcium- And Integrin-Binding Protein2 3 | | Calmyrin3 | | Kinase-Interacting Protein2 3 | | DNA-Dependent Protein Kinase Interacting Protein2 | | CIBP2 3 | | Snk Interacting Protein 2-282 | | DNA-PKcs-Interacting Protein2 3 | | Calmyrin3 | | SNK-Interacting Protein 2-282 3 | | PRKDCIP3 | | CALMYRIN1 | | |
Export aliases for CIB1 gene to outside databasesPrevious GC identifers: GC15P087395 GC15M084280 GC15M088360 GC15M088503 GC15M088574 GC15M066885 |
Summaries
for CIB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CIB1:
The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of thisprotein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase andmay play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrinalpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CIB1_HUMAN, Q99828Function: May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to theintegrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focaladhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Mayplay a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis inwhich both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation
Gene Wiki entry for CIB1
|
Genomic Views
for CIB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010274.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CIB1 gene promoter:
RFX1 Sp1 Brachyury Egr-1 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 Egr-4 YY1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for CIB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.3-q26 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q25.3-q26CIB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M090773: view genomic region
(about GC identifiers)
Start:
|
90,773,207 bp from pter |
End:
|
90,777,279 bp from pter |
Size:
|
4,073 bases |
Orientation:
|
minus strand |
|
Proteins
for CIB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CIB1_HUMAN, Q99828 (See
protein sequence)Recommended Name: Calcium and integrin-binding protein 1 Size: 191 amino acids; 21703 Da
Subunit: Monomer. Interacts with the heterodimeric integrin alpha-IIb/beta3. Interacts with the protein kinasesPLK2/SNK and with the region immediately upstream of the kinase domain of DNA-PK. Interacts with PLK3; leading toinhibit PLK3 kinase activity. Interacts with PSEN2. Interacts with MYO1C (By similarity). Interacts (via C-terminus)with F8. Interacts with NBR1 (via C-terminus). Interacts with FEZ1 (via C-terminus). Interacts with UBR5 (viaC-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation.Interacts with IFI6. Interacts with BCL2. Interacts with TAS1R2 (via C-terminus); this interaction is independent ofthe myristoylation state of CIB1. Interacts with ITPR3; in a calcium dependent manner. Interacts with PTK2/FAK1.Interacts with MAP3K5; inhibiting MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2
Subcellular location: Membrane; Lipid-anchor. Cytoplasm. Nucleus. Cell projection, filopodium. Apical cell membrane.Note=Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of tastereceptor cells
6/7 PDB 3D structures from  and Proteopedia  for CIB1 (see all 7):1DGU (3D)
1DGV (3D)
1XO5 (3D)
1Y1A (3D)
2L4H (3D)
2L4I (3D)
Secondary accessions: B5BU40 O00693 O00735 Q6IB49 Q96J54 Q99971Explore the universe of human proteins at neXtProt for CIB1: NX_Q99828
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99828
CIB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006375.2
ENSEMBL proteins: ENSP00000333873
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
CIB1 for ontologies About GeneDecksing
CIB1 Antibody Products:
Assay Products for CIB1: |
Protein
Domains /
Families
for CIB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CIB1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99828ProtoNet protein and cluster: Q99828 UniProtKB/Swiss-Prot: CIB1_HUMAN, Q99828Similarity: Contains 2 EF-hand domains |
Function
for CIB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CIB1_HUMAN, Q99828Function: May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to theintegrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focaladhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Mayplay a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis inwhich both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CIB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CIB1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CIB1 (NM_006384) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CIB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIB1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CIB1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Cib1tm1Prse for CIB1
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cib1):
CIB1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CIB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion_Integrin inside-out signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CIB1
1  GeneGo (Thomson Reuters) Pathway for CIB1
CIB1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CIB1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/26 Interacting proteins for CIB1 (Q998282, 3 ENSP000003338734) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
CIB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CIB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CIB1 for compounds About GeneDecksing
 Browse Tocris compounds for CIB1
8 Novoseek chemical compound relationships for CIB1 gene About this table
Search CenterWatch for drugs/clinical trials and news about CIB1
|
Transcripts
for CIB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CIB1 gene: NM_006384.3 Unigene Cluster for CIB1: Calcium and integrin binding 1 (calmyrin) Hs.715556 [show with all ESTs]Unigene Representative Sequence: BM4671051 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000328649(uc002bpb.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CIB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CIB1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CIB1 (NM_006384) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CIB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIB1 |
Additional cDNA sequence: AB451276.1 AB451406.1 BC000846.2 CR456955.1 JQ246073.1 U82226.1 U83236.1 U85611.1 22 DOTS entries: DT.75123307 DT.95274783 DT.95274797 DT.102833468 DT.95363029 DT.97864539 DT.100813547 DT.121026732 DT.100813546 DT.91744994 DT.92441628 DT.102832378 DT.121026742 DT.439451 DT.91960323 DT.95274812 DT.100813545 DT.100880913 DT.449823 DT.75107081 DT.91772111 DT.95200729 24/439 AceView cDNA sequences (see all 439): BQ924681 AI200875 BM985016 BG180446 BE872363 BQ689413 CA443331 CR626397 BQ940076 BM983981 BG823659 AI470697 AI934804 BG281393 BM708932 BM310299 BM752042 AA826393 BQ230705 BU162762 CR604330 BU069776 AJ713219 BQ668916
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CIB1 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e |
|---|
|
| SP1: | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CIB1
|
Expression
for CIB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CIB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGAGGGCG
About this image
See CIB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CIB1
SOURCE GeneReport for Unigene cluster: Hs.715556
UniProtKB/Swiss-Prot: CIB1_HUMAN, Q99828Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Array including CIB1: | DNA Damage Signaling Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CIB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CIB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIB1 |
Orthologs
for CIB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CIB1 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CIB11 |
calcium and integrin binding 1 (calmyrin) |
75.31(n)
74.07(a) |
|
770162 XM_001233494.2 XP_001233495.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.139092 |
Xenopus laevis transcribed sequence with weak similarity more |
75.97(n) |
|
BJ624062.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc44f062 |
Transcribed sequence with moderate similarity to protein more |
72.13(n) |
|
BM141096.1 |
mosquito
(Anopheles gambiae) |
Insecta |
AgaP_AGAP0084741 |
AGAP008474-PA |
52.61(n)
47.57(a) |
|
1277504 XM_316971.3 XP_316971.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G184306 |
EF-hand, calcium binding motif-containing protein |
27(a) |
1 → many |
3(6325915-6327692) |
rice
(Oryza sativa) |
Liliopsida |
-- |
EF hand family protein, putative, expressed |
28(a) |
1 → many |
2(34200999-34203985) |
ENSEMBL Gene Tree for CIB1 (if available)
TreeFam Gene Tree for CIB1 (if available) |
Paralogs
for CIB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CIB1 gene
- CIB32 PPP3R22 CIB42 PPP3R12 WDR922 CHP22 TESC2 CIB22
- CHP12
4 SIMAP similar genes for CIB1 using alignment to 1 protein entry: CIB1_HUMAN:CIB2 CIB3 CIB4 PPP3R1
CIB1 for paralogs About GeneDecksing
|
Genomic Variants
for CIB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CIB1 (90773207 - 90777279 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for CIB1
7 CNVs: 77066 8803 3976 3094 77067 9752 37691 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CIB1 |
|
Disorders
/ Diseases
for CIB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CIB1 for disorders About GeneDecksing
OMIM gene information: 602293
OMIM disorders: --
20/23  diseases for CIB1 (see all 23): About MalaCardswiskott-aldrich syndrome papillary thyroid carcinoma dilated cardiomyopathy kaposi's sarcoma
thyroid carcinoma alzheimer's disease down syndrome hepatitis c
gastric cancer cardiomyopathy breast cancer lung adenocarcinoma
thyroiditis sarcoma hepatocellular carcinoma retinoblastoma
pancreatic cancer adenocarcinoma carcinoma pancreatitis
6 Novoseek disease relationships for CIB1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: CIB1 (3 documents)
Export disorders for CIB1 gene to outside databases
|
Publications
for CIB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CIB1 gene, integrated from 9 sources (see all 106):
(articles sorted by number of sources associating them with CIB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP). (PubMed id 10826701)1, 2, 3, 9 Hattori A.... Saito T. (2000)
- Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. (PubMed id 9030514)1, 2, 3 Naik U.P.... Parise L.V. (1997)
- Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain. (PubMed id 12023286)1, 2, 9 Barry W.T.... Parise L.V. (2002)
- Auxiliary Ca2+ binding sites can influence the structure of CIB1. (PubMed id 19388079)1, 2, 9 Yamniuk A.P.... Vogel H.J. (2009)
- Sweet taste receptor interacting protein CIB1 is a general inhibitor of InsP3-dependent Ca2+ release in vivo. (PubMed id 18627437)1, 2, 9 Hennigs J.K.... Schmale H. (2008)
- Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen. (PubMed id 12714504)1, 2, 9 Naik U.P. and Naik M.U. (2003)
- Calcium-binding calmyrin forms stable covalent dimers in vitro, but in vivo is found in monomeric form. (PubMed id 15933764)1, 2, 9 Sobczak A....Wojda U. (2005)
- Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies. (PubMed id 10822252)1, 2, 9 Hwang P.M. and Vogel H.J. (2000)
- G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. (PubMed id 15685448)1, 2, 9 Tahara E. Jr.... Tahara E. (2005)
- Interaction between DNA-dependent protein kinase and a novel protein, KIP. (PubMed id 9372844)1, 2, 9 Wu X. and Lieber M.R. (1997)
|
External Searches for CIB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CIB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CIB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CIB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CIB1 gene:
Search GeneIP for patents involving CIB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CIB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CIB1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CIB1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CIB1 | | | OriGene Protein Over-expression Lysate for CIB1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CIB1 | | OriGene 3'-UTR Clone for CIB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CIB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CIB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CIB1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CIB1 | | OriGene Custom Protein Services for CIB1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CIB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CIB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CIB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIB1 |
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| | | | Search Tocris compounds for CIB1 |
| |  |  |  |  | | | | | | Recombinant Protein for CIB1 |
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 | | | CIB1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIB1 |
|  |  |  | | | | ThermoFisher Antibodies for CIB1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIB1 |
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