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Aliases for CIART Gene

Aliases for CIART Gene

  • Circadian Associated Repressor Of Transcription 2 3
  • Computationally Highlighted Repressor Of The Network Oscillator 3 4
  • ChIP-Derived Repressor Of Network Oscillator 3 4
  • C1orf51 3 4
  • CHRONO 3 4
  • Circadian-Associated Transcriptional Repressor 3
  • Chromosome 1 Open Reading Frame 51 2
  • GM129 3

External Ids for CIART Gene

Previous HGNC Symbols for CIART Gene

  • C1orf51

Previous GeneCards Identifiers for CIART Gene

  • GC01P150255

Summaries for CIART Gene

GeneCards Summary for CIART Gene

CIART (Circadian Associated Repressor Of Transcription) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CIART Gene

  • Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5-CACGTG-3) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIART Gene

Genomics for CIART Gene

Genomic Location for CIART Gene

Start:
150,282,521 bp from pter
End:
150,287,093 bp from pter
Size:
4,573 bases
Orientation:
Plus strand

Genomic View for CIART Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIART Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIART Gene

No data available for Regulatory Elements for CIART Gene

Proteins for CIART Gene

  • Protein details for CIART Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N365-CIART_HUMAN
    Recommended name:
    Circadian-associated transcriptional repressor
    Protein Accession:
    Q8N365
    Secondary Accessions:
    • B2RD43
    • D3DV01
    • Q8N795
    • Q96MG6

    Protein attributes for CIART Gene

    Size:
    385 amino acids
    Molecular mass:
    41443 Da
    Quaternary structure:
    • Interacts with PER2, CRY2, BHLHE41, HDAC1 and NR3C1 (By similarity). Interacts with ARNTL/BMAL1.

    Alternative splice isoforms for CIART Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIART Gene

Proteomics data for CIART Gene at MOPED

Post-translational modifications for CIART Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CIART Gene

Domains for CIART Gene

Protein Domains for CIART Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIART: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CIART Gene

Function for CIART Gene

Molecular function for CIART Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5-CACGTG-3) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).

Gene Ontology (GO) - Molecular Function for CIART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IDA 24385426
GO:0005515 protein binding IPI 24385426
GO:0070888 E-box binding ISS --
genes like me logo Genes that share ontologies with CIART: view

Phenotypes for CIART Gene

GenomeRNAi human phenotypes for CIART:
genes like me logo Genes that share phenotypes with CIART: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIART

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CIART Gene

Localization for CIART Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIART Gene

Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for CIART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with CIART: view

No data available for Subcellular locations from COMPARTMENTS for CIART Gene

Pathways for CIART Gene

SuperPathways for CIART Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0032922 circadian regulation of gene expression ISS --
GO:0045475 locomotor rhythm ISS --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with CIART: view

No data available for Pathways by source for CIART Gene

Transcripts for CIART Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIART

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIART Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for CIART Gene

GeneLoc Exon Structure for
CIART
ECgene alternative splicing isoforms for
CIART

Expression for CIART Gene

mRNA expression in normal human tissues for CIART Gene

genes like me logo Genes that share expressions with CIART: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for CIART Gene

Orthologs for CIART Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIART Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf51 36
  • 99 (a)
OneToOne
CIART 35
  • 99.31 (n)
  • 98.7 (a)
cow
(Bos Taurus)
Mammalia C1orf51 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf51 36
  • 68 (a)
OneToOne
CIART 35
  • 87.67 (n)
  • 83.07 (a)
mouse
(Mus musculus)
Mammalia Ciart 35
  • 81.58 (n)
  • 80.32 (a)
Gm129 16
Gm129 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf51 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1566380 35
  • 80.94 (n)
  • 79.83 (a)
lizard
(Anolis carolinensis)
Reptilia C1orf51 36
  • 31 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C19H1orf51 (1 of 2) 36
  • 29 (a)
OneToMany
C25H1orf51 (2 of 2) 36
  • 25 (a)
OneToMany
Species with no ortholog for CIART:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIART Gene

ENSEMBL:
Gene Tree for CIART (if available)
TreeFam:
Gene Tree for CIART (if available)

Paralogs for CIART Gene

No data available for Paralogs for CIART Gene

Variants for CIART Gene

Sequence variations from dbSNP and Humsavar for CIART Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9126 -- 150,286,988(+) TTCTA(A/C)TTTGT utr-variant-3-prime
rs942452 -- 150,284,919(-) GAGTT(C/T)CTCCC intron-variant
rs942453 -- 150,284,852(-) GACAA(C/T)GCAGA intron-variant
rs1122967 -- 150,286,426(-) TGCTA(C/G)AGAGG intron-variant
rs1815302 -- 150,285,523(-) GTTTC(A/G)CTCTT intron-variant

Relevant External Links for CIART Gene

HapMap Linkage Disequilibrium report
CIART

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CIART Gene

Disorders for CIART Gene

No disorders were found for CIART Gene.

No data available for UniProtKB/Swiss-Prot for CIART Gene

Publications for CIART Gene

  1. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. (PMID: 24385426) Annayev Y. … Ye R. (J. Biol. Chem. 2014) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CIART Gene

Sources for CIART Gene

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