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Aliases for CIART Gene

Aliases for CIART Gene

  • Circadian Associated Repressor Of Transcription 2 3 5
  • Computationally Highlighted Repressor Of The Network Oscillator 3 4
  • ChIP-Derived Repressor Of Network Oscillator 3 4
  • C1orf51 3 4
  • CHRONO 3 4
  • Circadian-Associated Transcriptional Repressor 3
  • Chromosome 1 Open Reading Frame 51 2
  • GM129 3

External Ids for CIART Gene

Previous HGNC Symbols for CIART Gene

  • C1orf51

Previous GeneCards Identifiers for CIART Gene

  • GC01P150255

Summaries for CIART Gene

GeneCards Summary for CIART Gene

CIART (Circadian Associated Repressor Of Transcription) is a Protein Coding gene. Diseases associated with CIART include Primary Syphilis. GO annotations related to this gene include core promoter sequence-specific DNA binding and E-box binding.

UniProtKB/Swiss-Prot for CIART Gene

  • Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5-CACGTG-3) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIART Gene

Genomics for CIART Gene

Regulatory Elements for CIART Gene

Enhancers for CIART Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F150249 0.2 ENCODE 11.8 -32.4 -32406 0.9 ZNF664 ATF3 CIART RPRD2 CA14 RNU2-17P
GH01F150213 1.3 FANTOM5 Ensembl ENCODE 11.6 -68.7 -68728 1.6 ATF1 PKNOX1 YY1 ELK1 ZNF207 NFYC ZHX2 TBX21 ZNF518A ZNF592 ANP32E RNU2-17P CIART CA14 C1orf54 APH1A PLEKHO1 MTMR11 TARS2 RPRD2
GH01F150386 0.5 Ensembl ENCODE 10.4 +104.8 104825 1.9 TBP ARID4B RARA YY1 ZNF121 SCRT2 MIXL1 ZNF362 KAT8 MAFF CIART ECM1 ADAMTSL4 SEMA6C GC01M150369 GC01P150425
GH01F150464 0.5 ENCODE 10.4 +182.0 181997 0.2 CTCF ARID4B SIN3A RAD21 ZFHX2 EGR1 ZNF143 SMC3 KLF13 EGR2 TARS2 MIR6878 ECM1 ADAMTSL4 LOC100289061 ADAMTSL4-AS1 CA14 CIART CTSK UBE2D3P3
GH01F150372 0.4 Ensembl 10.4 +91.2 91168 2.6 PKNOX1 ZNF121 ZFHX2 ZNF600 WT1 PRDM1 EGR2 SP7 MRPS21 CIART CA14 ECM1 CTSS SEMA6C HORMAD1 ADAMTSL4 GC01M150369 GC01P150425
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CIART on UCSC Golden Path with GeneCards custom track

Promoters for CIART Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001750040 -333 2001 HDGF PKNOX1 ARNT SIN3A FEZF1 YY1 GLIS2 ELK1 ZNF143 ZNF207
ENSR00000544736 1167 200 ELF3 HDAC1 TBL1XR1 ZFP64 RAD21 YY1 GATA2 ZNF366 CREM DEK

Genomic Location for CIART Gene

Chromosome:
1
Start:
150,282,533 bp from pter
End:
150,287,093 bp from pter
Size:
4,561 bases
Orientation:
Plus strand

Genomic View for CIART Gene

Genes around CIART on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIART Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIART Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIART Gene

Proteins for CIART Gene

  • Protein details for CIART Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N365-CIART_HUMAN
    Recommended name:
    Circadian-associated transcriptional repressor
    Protein Accession:
    Q8N365
    Secondary Accessions:
    • B2RD43
    • D3DV01
    • Q8N795
    • Q96MG6

    Protein attributes for CIART Gene

    Size:
    385 amino acids
    Molecular mass:
    41443 Da
    Quaternary structure:
    • Interacts with PER2, CRY2, BHLHE41, HDAC1 and NR3C1 (By similarity). Interacts with ARNTL/BMAL1.

    Alternative splice isoforms for CIART Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIART Gene

Post-translational modifications for CIART Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CIART Gene

Domains & Families for CIART Gene

Protein Domains for CIART Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIART Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIART: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CIART Gene

Function for CIART Gene

Molecular function for CIART Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5-CACGTG-3) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).

Gene Ontology (GO) - Molecular Function for CIART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IDA 24385426
GO:0005515 protein binding IPI 24385426
GO:0070888 E-box binding IEA,ISS --
genes like me logo Genes that share ontologies with CIART: view
genes like me logo Genes that share phenotypes with CIART: view

Animal Models for CIART Gene

MGI Knock Outs for CIART:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CIART Gene

Localization for CIART Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIART Gene

Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for CIART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with CIART: view

No data available for Subcellular locations from COMPARTMENTS for CIART Gene

Pathways & Interactions for CIART Gene

SuperPathways for CIART Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0032922 circadian regulation of gene expression ISS --
GO:0045475 locomotor rhythm IEA,ISS --
GO:0045892 negative regulation of transcription, DNA-templated IEA,ISS --
genes like me logo Genes that share ontologies with CIART: view

No data available for Pathways by source and SIGNOR curated interactions for CIART Gene

Transcripts for CIART Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIART Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for CIART Gene

GeneLoc Exon Structure for
CIART
ECgene alternative splicing isoforms for
CIART

Expression for CIART Gene

mRNA expression in normal human tissues for CIART Gene

NURSA nuclear receptor signaling pathways regulating expression of CIART Gene:

CIART
genes like me logo Genes that share expression patterns with CIART: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CIART Gene

Orthologs for CIART Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIART Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIART 34
  • 99.31 (n)
C1orf51 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIART 34
  • 87.67 (n)
C1orf51 35
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ciart 34 16
  • 81.58 (n)
Gm129 35
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf51 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1566380 34
  • 80.94 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf51 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf51 35
  • 31 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C19H1orf51 (1 of 2) 35
  • 29 (a)
OneToMany
C25H1orf51 (2 of 2) 35
  • 25 (a)
OneToMany
Species where no ortholog for CIART was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIART Gene

ENSEMBL:
Gene Tree for CIART (if available)
TreeFam:
Gene Tree for CIART (if available)

Paralogs for CIART Gene

No data available for Paralogs for CIART Gene

Variants for CIART Gene

Sequence variations from dbSNP and Humsavar for CIART Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10691120 -- 150,286,107(+) ACTTC(-/TTTTC)AAAGA intron-variant
rs111979153 -- 150,284,303(+) CGTAA(A/G)CCACC intron-variant
rs1122967 -- 150,286,426(-) TGCTA(C/G)AGAGG intron-variant
rs112315972 -- 150,286,391(+) TGCTT(C/T)CTCCA intron-variant
rs112709322 -- 150,284,726(+) GAACA(C/T)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIART Gene

Variant ID Type Subtype PubMed ID
nsv1009508 CNV loss 25217958
nsv1011223 CNV gain 25217958

Variation tolerance for CIART Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIART Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIART

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIART Gene

Disorders for CIART Gene

MalaCards: The human disease database

(1) MalaCards diseases for CIART Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary syphilis
  • early symptomatic syphilis
- elite association - COSMIC cancer census association via MalaCards
Search CIART in MalaCards View complete list of genes associated with diseases

Relevant External Links for CIART

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CIART
genes like me logo Genes that share disorders with CIART: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CIART Gene

Publications for CIART Gene

  1. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. (PMID: 24385426) Annayev Y. … Ye R. (J. Biol. Chem. 2014) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CIART Gene

Sources for CIART Gene

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