Aliases for CIART Gene
Aliases for CIART Gene
External Ids for CIART Gene
- HGNC: 25200
- Entrez Gene: 148523
- Ensembl: ENSG00000159208
- OMIM: 615782
- UniProtKB: Q8N365
Previous HGNC Symbols for CIART Gene
- C1orf51
Previous GeneCards Identifiers for CIART Gene
- GC01P150255
Summaries for CIART Gene
GeneCards Summary for CIART Gene
CIART (Circadian Associated Repressor Of Transcription) is a Protein Coding gene. Among its related pathways are Circadian rythm related genes. GO annotations related to this gene include core promoter sequence-specific DNA binding and E-box binding.
UniProtKB/Swiss-Prot for CIART Gene
-
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5-CACGTG-3) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIART Gene
Genomics for CIART Gene
Regulatory Elements for CIART Gene
Regulatory Element Products
Genomic Location for CIART Gene
- Chromosome:
- 1
- Start:
- 150,282,533 bp from pter
- End:
- 150,287,093 bp from pter
- Size:
- 4,561 bases
- Orientation:
- Plus strand
Genomic View for CIART Gene
- Cytogenetic band:
-
- 1q21.2 by Ensembl
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CIART Gene
Proteins for CIART Gene
-
Protein details for CIART Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N365-CIART_HUMAN
- Recommended name:
- Circadian-associated transcriptional repressor
- Protein Accession:
- Q8N365
- B2RD43
- D3DV01
- Q8N795
- Q96MG6
Protein attributes for CIART Gene
- Size:
- 385 amino acids
- Molecular mass:
- 41443 Da
- Quaternary structure:
-
- Interacts with PER2, CRY2, BHLHE41, HDAC1 and NR3C1 (By similarity). Interacts with ARNTL/BMAL1.
Post-translational modifications for CIART Gene
Other Protein References for CIART Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CIART
- Novus Biologicals Antibodies for CIART
-
Abcam antibodies for CIART
- Invitrogen Antibodies for CIART
- Search GeneTex for Antibodies for CIART
Protein Products
-
OriGene Purified Proteins for CIART
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- Search GeneTex for Proteins for CIART
-
Abcam proteins for CIART
Assay Products
No data available for DME Specific Peptides for CIART Gene
Domains & Families for CIART Gene
Suggested Antigen Peptide Sequences for CIART Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CIART Gene
Function for CIART Gene
Molecular function for CIART Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5-CACGTG-3) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001046 | core promoter sequence-specific DNA binding | IDA | 24385426 |
| GO:0005515 | protein binding | IPI | 24385426 |
| GO:0070888 | E-box binding | IEA,ISS | -- |
Phenotypes for CIART Gene
- MGI mutant phenotypes for CIART:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CIART:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CIART
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CIART gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CIART gene
- Search ViGene Biosciences for CIART
CRISPR Products
-
OriGene CRISPR knockouts for CIART
-
Santa Cruz Biotechnology (SCBT) CRISPR for CIART
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miRNA Products
- Search ViGene Biosciences for CIART
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CIART
- Browse OriGene Inhibitory RNA Products For CIART
-
ViGene Biosciences ready-to-package AAV shRNAs for CIART gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CIART
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIART
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CIART
-
ViGene Biosciences adenoviral particle packaged cDNA for CIART gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CIART gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CIART gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CIART Gene
Localization for CIART Gene
Subcellular locations from UniProtKB/Swiss-Prot for CIART Gene
- Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body. {ECO:0000250}.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0016605 | PML body | IEA | -- |
Pathways & Interactions for CIART Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Circadian rythm related genes | ||
Pathways by source for CIART Gene
1 BioSystems pathway for CIART Gene
Interacting Proteins for CIART Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0032922 | circadian regulation of gene expression | ISS | -- |
| GO:0045475 | locomotor rhythm | IEA,ISS | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | IEA,ISS | -- |
No data available for SIGNOR curated interactions for CIART Gene
Transcripts for CIART Gene
mRNA/cDNA for CIART Gene
- (6) REFSEQ mRNAs :
- (59) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CIART
-
Santa Cruz Biotechnology (SCBT) CRISPR for CIART
- GenScript: Design CRISPR guide RNA sequences for CIART
miRNA Products
- Search ViGene Biosciences for CIART
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CIART
- Browse OriGene Inhibitory RNA Products For CIART
-
ViGene Biosciences ready-to-package AAV shRNAs for CIART gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CIART
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIART
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||
| SP5: |
Expression for CIART Gene
NURSA nuclear receptor signaling pathways regulating expression of CIART Gene:
CIARTEvidence on tissue expression from TISSUES for CIART Gene
- Muscle(4.5)
- Nervous system(4.4)
- Heart(2.3)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for CIART
-
OriGene qPCR primer pairs and template standards for CIART
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIART Gene
Orthologs for CIART Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CIART 34 |
|
||
| C1orf51 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CIART 34 |
|
||
| C1orf51 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ciart 34 16 |
|
||
| Gm129 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C1orf51 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | RGD1566380 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C1orf51 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | C1orf51 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | C19H1orf51 (1 of 2) 35 |
|
OneToMany | |
| C25H1orf51 (2 of 2) 35 |
|
OneToMany |
- Species where no ortholog for CIART was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CIART Gene
No data available for Paralogs for CIART Gene
Variants for CIART Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001638670 | -- | 150,285,633(+) | AATCA(A/C)CAGTC | intron-variant | |
| rs1002646866 | -- | 150,284,168(+) | GCCCA(A/C)CACCA | intron-variant, upstream-variant-2KB | |
| rs1003875642 | -- | 150,286,963(+) | AGGGC(A/C)TACAG | utr-variant-3-prime | |
| rs1003905232 | -- | 150,287,325(+) | TTTTT(C/G)TTGTT | downstream-variant-500B | |
| rs1004493200 | -- | 150,281,127(+) | TAATT(A/C)TCTTG | intron-variant, downstream-variant-500B, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1009508 | CNV | loss | 25217958 |
| nsv1011223 | CNV | gain | 25217958 |
Relevant External Links for CIART Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CIART
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIART Gene
Disorders for CIART Gene
Relevant External Links for CIART
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CIART
No disorders were found for CIART Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIART Gene
Publications for CIART Gene
- Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. (PMID: 24385426) Annayev Y. … Ye R. (J. Biol. Chem. 2014) 2 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for CIART Gene
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- Custom Antibody ServicesOriGene Antibodies for CIART
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- OriGene qPCR primer pairs and template standards for CIART
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- GenScript: Design CRISPR guide RNA sequences for CIART
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- Novus Biologicals Antibodies for CIART
- Novus Biologicals proteins and lysates for CIART
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CIART
- Abcam proteins for CIART
- Search for Assays for CIART at Abcam
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- ViGene Biosciences adenoviral particle packaged cDNA for CIART gene
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- Horizon Cell Lines for CIART
- Cyagen custom Knockout/knockin (KOKI) mouse models for CIART
- VectorBuilder custom plasmid, inducible vectors for CIART
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIART
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CIART Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
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- (129) MeSH
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




