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Aliases for CIART Gene

Aliases for CIART Gene

  • Circadian Associated Repressor Of Transcription 2 3 5
  • Computationally Highlighted Repressor Of The Network Oscillator 3 4
  • ChIP-Derived Repressor Of Network Oscillator 3 4
  • C1orf51 3 4
  • CHRONO 3 4
  • Circadian-Associated Transcriptional Repressor 3
  • Chromosome 1 Open Reading Frame 51 2
  • GM129 3

External Ids for CIART Gene

Previous HGNC Symbols for CIART Gene

  • C1orf51

Previous GeneCards Identifiers for CIART Gene

  • GC01P150255

Summaries for CIART Gene

GeneCards Summary for CIART Gene

CIART (Circadian Associated Repressor Of Transcription) is a Protein Coding gene. Diseases associated with CIART include Primary Syphilis. Among its related pathways are Circadian rythm related genes. GO annotations related to this gene include core promoter sequence-specific DNA binding and E-box binding.

UniProtKB/Swiss-Prot for CIART Gene

  • Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5-CACGTG-3) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).

Additional gene information for CIART Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIART Gene

Genomics for CIART Gene

Regulatory Elements for CIART Gene

Enhancers for CIART Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H150213 1.6 FANTOM5 Ensembl ENCODE 11.6 -68.7 -68692 1 PKNOX1 SIN3A YY1 ELK1 ZNF207 ZNF143 RUNX3 NFYC REST ZNF518A ANP32E RNU2-17P CIART CA14 C1orf54 APH1A PLEKHO1 MTMR11 TARS2 RPRD2
GH01H150386 0.9 ENCODE 10.4 +104.8 104832 1 TBP FOXA2 ARID4B RARA YY1 ZNF121 SCRT2 MIXL1 ZNF362 KAT8 CIART ECM1 ADAMTSL4 SEMA6C GC01M150369 GC01P150425
GH01H150177 0.9 Ensembl ENCODE dbSUPER 10.2 -104.4 -104397 1 SCRT2 PLEKHO1 HIST2H2BE HIST2H2AC BOLA1 CIART LOC105371433 GC01P150213
GH01H150464 0.8 ENCODE 10.4 +182.0 181997 0 CTCF ESRRA ARID4B SIN3A ZBTB7B RAD21 ZFHX2 EGR1 SMC3 ZNF143 TARS2 ECM1 ADAMTSL4 LOC100289061 ADAMTSL4-AS1 CA14 CIART CTSK UBE2D3P3 GC01P150425
GH01H150191 0.8 Ensembl ENCODE 10 -90.3 -90300 2 MAFF JUND POLR2A JUN STAT3 RCOR1 EP300 PLEKHO1 VPS45 MTMR11 HIST2H2AC HIST2H2BE BOLA1 SF3B4 APH1A C1orf54 CA14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CIART on UCSC Golden Path with GeneCards custom track

Promoters for CIART Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013492 -333 1601 HDGF PKNOX1 SIN3A FEZF1 ZBTB7B YY1 GLIS2 ELK1 ZNF207 ZNF143

Genomic Location for CIART Gene

Chromosome:
1
Start:
150,282,533 bp from pter
End:
150,287,093 bp from pter
Size:
4,561 bases
Orientation:
Plus strand

Genomic View for CIART Gene

Genes around CIART on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIART Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIART Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIART Gene

Proteins for CIART Gene

  • Protein details for CIART Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N365-CIART_HUMAN
    Recommended name:
    Circadian-associated transcriptional repressor
    Protein Accession:
    Q8N365
    Secondary Accessions:
    • B2RD43
    • D3DV01
    • Q8N795
    • Q96MG6

    Protein attributes for CIART Gene

    Size:
    385 amino acids
    Molecular mass:
    41443 Da
    Quaternary structure:
    • Interacts with PER2, CRY2, BHLHE41, HDAC1 and NR3C1 (By similarity). Interacts with ARNTL/BMAL1.

    Alternative splice isoforms for CIART Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIART Gene

Post-translational modifications for CIART Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CIART Gene

Domains & Families for CIART Gene

Gene Families for CIART Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CIART Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIART Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIART: view

No data available for UniProtKB/Swiss-Prot for CIART Gene

Function for CIART Gene

Molecular function for CIART Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5-CACGTG-3) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).

Phenotypes From GWAS Catalog for CIART Gene

Gene Ontology (GO) - Molecular Function for CIART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IDA,IEA 24385426
GO:0005515 protein binding IPI 24385426
GO:0070888 E-box binding IEA,ISS --
genes like me logo Genes that share ontologies with CIART: view
genes like me logo Genes that share phenotypes with CIART: view

Animal Models for CIART Gene

MGI Knock Outs for CIART:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CIART
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CIART Gene

Localization for CIART Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIART Gene

Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CIART gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CIART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with CIART: view

Pathways & Interactions for CIART Gene

genes like me logo Genes that share pathways with CIART: view

Pathways by source for CIART Gene

1 BioSystems pathway for CIART Gene

Gene Ontology (GO) - Biological Process for CIART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0032922 circadian regulation of gene expression ISS --
GO:0045475 locomotor rhythm ISS,IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA,ISS --
genes like me logo Genes that share ontologies with CIART: view

No data available for SIGNOR curated interactions for CIART Gene

Drugs & Compounds for CIART Gene

No Compound Related Data Available

Transcripts for CIART Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CIART
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CIART Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for CIART Gene

GeneLoc Exon Structure for
CIART
ECgene alternative splicing isoforms for
CIART

Expression for CIART Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CIART Gene

NURSA nuclear receptor signaling pathways regulating expression of CIART Gene:

CIART

Evidence on tissue expression from TISSUES for CIART Gene

  • Muscle(4.5)
  • Nervous system(4.4)
  • Heart(2.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with CIART: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIART Gene

Orthologs for CIART Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIART Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIART 33
  • 99.31 (n)
C1orf51 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIART 33
  • 87.67 (n)
C1orf51 34
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ciart 33 16
  • 81.58 (n)
Gm129 34
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf51 34
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1566380 33
  • 80.94 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf51 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf51 34
  • 31 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C19H1orf51 (1 of 2) 34
  • 29 (a)
OneToMany
C25H1orf51 (2 of 2) 34
  • 25 (a)
OneToMany
Species where no ortholog for CIART was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIART Gene

ENSEMBL:
Gene Tree for CIART (if available)
TreeFam:
Gene Tree for CIART (if available)

Paralogs for CIART Gene

No data available for Paralogs for CIART Gene

Variants for CIART Gene

Sequence variations from dbSNP and Humsavar for CIART Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001638670 -- 150,285,633(+) AATCA(A/C)CAGTC intron-variant
rs1002646866 -- 150,284,168(+) GCCCA(A/C)CACCA intron-variant, upstream-variant-2KB
rs1003875642 -- 150,286,963(+) AGGGC(A/C)TACAG utr-variant-3-prime
rs1003905232 -- 150,287,325(+) TTTTT(C/G)TTGTT downstream-variant-500B
rs1004493200 -- 150,281,127(+) TAATT(A/C)TCTTG intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CIART Gene

Variant ID Type Subtype PubMed ID
nsv1009508 CNV loss 25217958
nsv1011223 CNV gain 25217958

Variation tolerance for CIART Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIART Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIART

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIART Gene

Disorders for CIART Gene

MalaCards: The human disease database

(1) MalaCards diseases for CIART Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary syphilis
  • early symptomatic syphilis
- elite association - COSMIC cancer census association via MalaCards
Search CIART in MalaCards View complete list of genes associated with diseases

Relevant External Links for CIART

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CIART
genes like me logo Genes that share disorders with CIART: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CIART Gene

Publications for CIART Gene

  1. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. (PMID: 24385426) Annayev Y … Ye R (The Journal of biological chemistry 2014) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for CIART Gene

Sources for CIART Gene

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