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Aliases for CIART Gene

Aliases for CIART Gene

  • Circadian Associated Repressor Of Transcription 2 3 5
  • Computationally Highlighted Repressor Of The Network Oscillator 3 4
  • ChIP-Derived Repressor Of Network Oscillator 3 4
  • C1orf51 3 4
  • CHRONO 3 4
  • Chromosome 1 Open Reading Frame 51 2
  • GM129 3

External Ids for CIART Gene

Previous HGNC Symbols for CIART Gene

  • C1orf51

Previous GeneCards Identifiers for CIART Gene

  • GC01P150255

Summaries for CIART Gene

GeneCards Summary for CIART Gene

CIART (Circadian Associated Repressor Of Transcription) is a Protein Coding gene. GO annotations related to this gene include core promoter sequence-specific DNA binding and E-box binding.

UniProtKB/Swiss-Prot for CIART Gene

  • Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5-CACGTG-3) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIART Gene

Genomics for CIART Gene

Regulatory Elements for CIART Gene

Enhancers for CIART Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CIART on UCSC Golden Path with GeneCards custom track

Promoters for CIART Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CIART on UCSC Golden Path with GeneCards custom track

Genomic Location for CIART Gene

Chromosome:
1
Start:
150,282,533 bp from pter
End:
150,287,093 bp from pter
Size:
4,561 bases
Orientation:
Plus strand

Genomic View for CIART Gene

Genes around CIART on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIART Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIART Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIART Gene

Proteins for CIART Gene

  • Protein details for CIART Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N365-CIART_HUMAN
    Recommended name:
    Circadian-associated transcriptional repressor
    Protein Accession:
    Q8N365
    Secondary Accessions:
    • B2RD43
    • D3DV01
    • Q8N795
    • Q96MG6

    Protein attributes for CIART Gene

    Size:
    385 amino acids
    Molecular mass:
    41443 Da
    Quaternary structure:
    • Interacts with PER2, CRY2, BHLHE41, HDAC1 and NR3C1 (By similarity). Interacts with ARNTL/BMAL1.

    Alternative splice isoforms for CIART Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIART Gene

Proteomics data for CIART Gene at MOPED

Post-translational modifications for CIART Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CIART Gene

Domains & Families for CIART Gene

Protein Domains for CIART Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIART Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIART: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CIART Gene

Function for CIART Gene

Molecular function for CIART Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5-CACGTG-3) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).
genes like me logo Genes that share phenotypes with CIART: view

Animal Models for CIART Gene

MGI Knock Outs for CIART:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CIART Gene

Localization for CIART Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIART Gene

Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body. {ECO:0000250}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CIART Gene

Pathways & Interactions for CIART Gene

SuperPathways for CIART Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032922 circadian regulation of gene expression IEA,ISS --
GO:0045475 locomotor rhythm IEA,ISS --
genes like me logo Genes that share ontologies with CIART: view

No data available for Pathways by source and SIGNOR curated interactions for CIART Gene

Drugs & Compounds for CIART Gene

No Compound Related Data Available

Transcripts for CIART Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CIART Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for CIART Gene

GeneLoc Exon Structure for
CIART
ECgene alternative splicing isoforms for
CIART

Expression for CIART Gene

mRNA expression in normal human tissues for CIART Gene

genes like me logo Genes that share expression patterns with CIART: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CIART Gene

Orthologs for CIART Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIART Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CIART 35
  • 87.67 (n)
  • 83.07 (a)
C1orf51 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ciart 35
  • 81.58 (n)
  • 80.32 (a)
Ciart 16
Gm129 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CIART 35
  • 99.31 (n)
  • 98.7 (a)
C1orf51 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1566380 35
  • 80.94 (n)
  • 79.83 (a)
cow
(Bos Taurus)
Mammalia C1orf51 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf51 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf51 36
  • 31 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C19H1orf51 (1 of 2) 36
  • 29 (a)
OneToMany
C25H1orf51 (2 of 2) 36
  • 25 (a)
OneToMany
Species with no ortholog for CIART:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIART Gene

ENSEMBL:
Gene Tree for CIART (if available)
TreeFam:
Gene Tree for CIART (if available)

Paralogs for CIART Gene

No data available for Paralogs for CIART Gene

Variants for CIART Gene

Sequence variations from dbSNP and Humsavar for CIART Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9126 -- 150,286,988(+) TTCTA(A/C)TTTGT utr-variant-3-prime
rs1122967 -- 150,286,426(-) TGCTA(C/G)AGAGG intron-variant
rs942452 -- 150,284,919(-) GAGTT(C/T)CTCCC intron-variant
rs942453 -- 150,284,852(-) GACAA(C/T)GCAGA intron-variant
rs2147324 -- 150,283,177(-) AAACC(A/G)GAGTT intron-variant, utr-variant-5-prime

Variation tolerance for CIART Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CIART Gene

Disorders for CIART Gene

Relevant External Links for CIART

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CIART

No disorders were found for CIART Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIART Gene

Publications for CIART Gene

  1. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. (PMID: 24385426) Annayev Y. … Ye R. (J. Biol. Chem. 2014) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. (PMID: 24736997) Goriki A. … Takumi T. (PLoS Biol. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CIART Gene

Sources for CIART Gene

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