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Aliases for CIAPIN1 Gene

Aliases for CIAPIN1 Gene

  • Cytokine Induced Apoptosis Inhibitor 1 2 3 5
  • Fe-S Cluster Assembly Protein DRE2 Homolog 3 4
  • Cytokine-Induced Apoptosis Inhibitor 1 3 4
  • Predicted Protein Of HQ0915 3
  • Anamorsin 3
  • PRO0915 3
  • DRE2 3

External Ids for CIAPIN1 Gene

Previous GeneCards Identifiers for CIAPIN1 Gene

  • GC16M056019
  • GC16M043329

Summaries for CIAPIN1 Gene

Entrez Gene Summary for CIAPIN1 Gene

  • CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CIAPIN1 Gene

CIAPIN1 (Cytokine Induced Apoptosis Inhibitor 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. GO annotations related to this gene include methyltransferase activity and iron-sulfur cluster binding.

UniProtKB/Swiss-Prot for CIAPIN1 Gene

  • Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1.

Gene Wiki entry for CIAPIN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIAPIN1 Gene

Genomics for CIAPIN1 Gene

Regulatory Elements for CIAPIN1 Gene

Promoters for CIAPIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CIAPIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CIAPIN1 Gene

Chromosome:
16
Start:
57,428,169 bp from pter
End:
57,447,528 bp from pter
Size:
19,360 bases
Orientation:
Minus strand

Genomic View for CIAPIN1 Gene

Genes around CIAPIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIAPIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIAPIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIAPIN1 Gene

Proteins for CIAPIN1 Gene

  • Protein details for CIAPIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6FI81-CPIN1_HUMAN
    Recommended name:
    Anamorsin
    Protein Accession:
    Q6FI81
    Secondary Accessions:
    • A8K8B6
    • O75206
    • O75207
    • Q9H0W1
    • Q9P1L7

    Protein attributes for CIAPIN1 Gene

    Size:
    312 amino acids
    Molecular mass:
    33582 Da
    Cofactor:
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    • Monomer. Interacts with NDOR1; its oxidized form can be reduced by NDOR1. Interacts with CHCHD4 and may be a substrate for CHCHD4 chaperone activity.
    Miscellaneous:
    • Ana-mors-in means anti-death molecule in Latin.
    SequenceCaution:
    • Sequence=AAC24312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CIAPIN1 Gene

    Alternative splice isoforms for CIAPIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIAPIN1 Gene

Proteomics data for CIAPIN1 Gene at MOPED

Post-translational modifications for CIAPIN1 Gene

  • Ubiquitination at Lys 31, Lys 48, and Lys 96
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CIAPIN1 Gene

Domains & Families for CIAPIN1 Gene

Protein Domains for CIAPIN1 Gene

Suggested Antigen Peptide Sequences for CIAPIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6FI81

UniProtKB/Swiss-Prot:

CPIN1_HUMAN :
  • The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine.
  • Belongs to the anamorsin family.
Domain:
  • The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine.
  • The C-terminal domain binds one 2Fe-2S iron-sulfur cluster but is otherwise mostly in an intrinsically disordered conformation.
  • The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Family:
  • Belongs to the anamorsin family.
genes like me logo Genes that share domains with CIAPIN1: view

No data available for Gene Families for CIAPIN1 Gene

Function for CIAPIN1 Gene

Molecular function for CIAPIN1 Gene

UniProtKB/Swiss-Prot Function:
Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1.

Gene Ontology (GO) - Molecular Function for CIAPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with CIAPIN1: view
genes like me logo Genes that share phenotypes with CIAPIN1: view

Animal Models for CIAPIN1 Gene

MGI Knock Outs for CIAPIN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CIAPIN1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CIAPIN1 Gene

Localization for CIAPIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIAPIN1 Gene

Cytoplasm. Nucleus. Mitochondrion. Mitochondrion intermembrane space. Note=Imported into mitochondria (in vitro).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIAPIN1 Gene COMPARTMENTS Subcellular localization image for CIAPIN1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CIAPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 16957168
GO:0005737 cytoplasm IEA,ISS 14970183
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CIAPIN1: view

Pathways & Interactions for CIAPIN1 Gene

genes like me logo Genes that share pathways with CIAPIN1: view

Pathways by source for CIAPIN1 Gene

1 GeneTex pathway for CIAPIN1 Gene
2 Reactome pathways for CIAPIN1 Gene

Gene Ontology (GO) - Biological Process for CIAPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0043066 negative regulation of apoptotic process ISS 14970183
genes like me logo Genes that share ontologies with CIAPIN1: view

No data available for SIGNOR curated interactions for CIAPIN1 Gene

Drugs & Compounds for CIAPIN1 Gene

(5) Drugs for CIAPIN1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Birinapant (TL32711) Pharma Potent XIAP/cIAP1 antagonist 0
BV6 Pharma 0
GDC-0152 Pharma IAP antagonist,potent amd samll-molecule 0
SM-164 Pharma Anticancer agent 0
YM155 Pharma Survivin suppressant,apoptosis inhibitor, Survivin inhibitors 0
genes like me logo Genes that share compounds with CIAPIN1: view

Transcripts for CIAPIN1 Gene

Unigene Clusters for CIAPIN1 Gene

Cytokine induced apoptosis inhibitor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIAPIN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for CIAPIN1 Gene

GeneLoc Exon Structure for
CIAPIN1
ECgene alternative splicing isoforms for
CIAPIN1

Expression for CIAPIN1 Gene

mRNA expression in normal human tissues for CIAPIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CIAPIN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.6), Cervix (6.6), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CIAPIN1 Gene



SOURCE GeneReport for Unigene cluster for CIAPIN1 Gene Hs.4900

mRNA Expression by UniProt/SwissProt for CIAPIN1 Gene

Q6FI81-CPIN1_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in heart, liver and pancreas.
genes like me logo Genes that share expression patterns with CIAPIN1: view

Protein tissue co-expression partners for CIAPIN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CIAPIN1 Gene

Orthologs for CIAPIN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CIAPIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIAPIN1 35
  • 99.04 (n)
  • 99.36 (a)
CIAPIN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CIAPIN1 36
  • 91 (a)
OneToOne
CIAPIN1 35
  • 89.35 (n)
  • 91.29 (a)
dog
(Canis familiaris)
Mammalia CIAPIN1 35
  • 88.03 (n)
  • 86.86 (a)
CIAPIN1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ciapin1 16
Ciapin1 36
  • 82 (a)
OneToOne
Ciapin1 35
  • 82.96 (n)
  • 82.2 (a)
oppossum
(Monodelphis domestica)
Mammalia CIAPIN1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ciapin1 35
  • 83.93 (n)
  • 82.52 (a)
chicken
(Gallus gallus)
Aves CIAPIN1 36
  • 77 (a)
OneToOne
CIAPIN1 35
  • 72.34 (n)
  • 76.39 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398841 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ciapin1 35
  • 60.73 (n)
  • 61.17 (a)
zebrafish
(Danio rerio)
Actinopterygii ciapin1 36
  • 50 (a)
OneToOne
ciapin1 35
  • 60.93 (n)
  • 57.14 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta DRE2_ANOGA 35
  • 55.24 (n)
  • 48.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Bg 35
  • 55.22 (n)
  • 50.87 (a)
l(2)35Bg 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T20B12.7 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DRE2 36
  • 24 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G18400 35
  • 49.92 (n)
  • 43.54 (a)
rice
(Oryza sativa)
Liliopsida Os04g0674400 35
  • 51.01 (n)
  • 46.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9538 36
  • 45 (a)
OneToOne
Species with no ortholog for CIAPIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIAPIN1 Gene

ENSEMBL:
Gene Tree for CIAPIN1 (if available)
TreeFam:
Gene Tree for CIAPIN1 (if available)

Paralogs for CIAPIN1 Gene

Pseudogenes.org Pseudogenes for CIAPIN1 Gene

genes like me logo Genes that share paralogs with CIAPIN1: view

No data available for Paralogs for CIAPIN1 Gene

Variants for CIAPIN1 Gene

Sequence variations from dbSNP and Humsavar for CIAPIN1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11557672 - 57,440,828(-) TCAAG(A/C/T)GTTAA reference, missense
rs11557674 - 57,440,775(-) TGTTG(C/G)AATGT reference, missense
rs223878 -- 57,437,230(+) atagt(A/G)tgaaa intron-variant
rs223879 -- 57,438,801(+) TACAG(C/T)ACAGA intron-variant
rs178600 -- 57,429,643(+) CCCGC(C/T)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIAPIN1 Gene

Variant ID Type Subtype PubMed ID
nsv906724 CNV Loss 21882294
nsv833245 CNV Loss 17160897

Variation tolerance for CIAPIN1 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIAPIN1 Gene

HapMap Linkage Disequilibrium report
CIAPIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIAPIN1 Gene

Disorders for CIAPIN1 Gene

Relevant External Links for CIAPIN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CIAPIN1

No disorders were found for CIAPIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIAPIN1 Gene

Publications for CIAPIN1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis. (PMID: 18625724) Zhang Y. … Dancis A. (Mol. Cell. Biol. 2008) 3 23
  3. The expression of anamorsin in diffuse large B cell lymphoma: possible prognostic biomarker for low IPI patients. (PMID: 18203020) Shizusawa T. … Kanakura Y. (Leuk. Lymphoma 2008) 3 23
  4. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CIAPIN1 Gene

Sources for CIAPIN1 Gene

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