Aliases for CIAPIN1 Gene
Aliases for CIAPIN1 Gene
External Ids for CIAPIN1 Gene
- HGNC: 28050
- Entrez Gene: 57019
- Ensembl: ENSG00000005194
- OMIM: 608943
- UniProtKB: Q6FI81
Previous GeneCards Identifiers for CIAPIN1 Gene
- GC16M056019
- GC16M043329
Summaries for CIAPIN1 Gene
-
CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CIAPIN1 Gene
CIAPIN1 (Cytokine Induced Apoptosis Inhibitor 1) is a Protein Coding gene. Among its related pathways are Cytosolic iron-sulfur cluster assembly and Metabolism. GO annotations related to this gene include methyltransferase activity and iron-sulfur cluster binding.
UniProtKB/Swiss-Prot for CIAPIN1 Gene
-
Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIAPIN1 Gene
Genomics for CIAPIN1 Gene
Regulatory Elements for CIAPIN1 Gene
Enhancers for CIAPIN1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CIAPIN1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CIAPIN1 Gene
- Chromosome:
- 16
- Start:
- 57,428,169 bp from pter
- End:
- 57,447,528 bp from pter
- Size:
- 19,360 bases
- Orientation:
- Minus strand
Genomic View for CIAPIN1 Gene
Genes around CIAPIN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q21 by Ensembl
- 16q21 by Entrez Gene
- 16q21 by HGNC
CIAPIN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CIAPIN1 Gene
Proteins for CIAPIN1 Gene
-
Protein details for CIAPIN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6FI81-CPIN1_HUMAN
- Recommended name:
- Anamorsin
- Protein Accession:
- Q6FI81
- A8K8B6
- O75206
- O75207
- Q9H0W1
- Q9P1L7
Protein attributes for CIAPIN1 Gene
- Size:
- 312 amino acids
- Molecular mass:
- 33582 Da
- Cofactor:
- Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
- Quaternary structure:
-
- Monomer. Interacts with NDOR1; its oxidized form can be reduced by NDOR1. Interacts with CHCHD4 and may be a substrate for CHCHD4 chaperone activity.
- Miscellaneous:
-
- Ana-mors-in means anti-death molecule in Latin.
- SequenceCaution:
-
- Sequence=AAC24312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for CIAPIN1 Gene
Protein Expression for CIAPIN1 Gene
Post-translational modifications for CIAPIN1 Gene
Other Protein References for CIAPIN1 Gene
Antibody Products
- Novus Biologicals Antibodies for CIAPIN1
- Invitrogen Antibodies for CIAPIN1
- antibodies-online Antibodies for CIAPIN1: See all 59
- GeneTex CIAPIN1 antibody for CIAPIN1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CIAPIN1
Protein Products
-
OriGene Purified Proteins for CIAPIN1
- Search Origene for MassSpec and Protein Over-expression Lysates for CIAPIN1
- Origene Custom Protein Services for CIAPIN1
- ProSpec Recombinant Proteins for CIAPIN1
- antibodies-online Proteins for CIAPIN1: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CIAPIN1
Assay Products
- antibodies-online Kits for CIAPIN1: See all 1
No data available for DME Specific Peptides for CIAPIN1 Gene
Domains & Families for CIAPIN1 Gene
Gene Families for CIAPIN1 Gene
Protein Domains for CIAPIN1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CIAPIN1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6FI81UniProtKB/Swiss-Prot:
CPIN1_HUMAN :- The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine.
- Belongs to the anamorsin family.
- Domain:
-
- The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine.
- The C-terminal domain binds one 2Fe-2S iron-sulfur cluster but is otherwise mostly in an intrinsically disordered conformation.
- The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
- Family:
-
- Belongs to the anamorsin family.
Function for CIAPIN1 Gene
Molecular function for CIAPIN1 Gene
- UniProtKB/Swiss-Prot Function:
- Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0051536 | iron-sulfur cluster binding | IEA | -- |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | IDA,IEA | 27519415 |
Phenotypes for CIAPIN1 Gene
- MGI mutant phenotypes for CIAPIN1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CIAPIN1:
Animal Models for CIAPIN1 Gene
- MGI Knock Outs for CIAPIN1:
-
- Ciapin1 tm1Yzka
Animal Model Products
-
Taconic Biosciences Mouse Models for CIAPIN1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CIAPIN1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CIAPIN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CIAPIN1 gene
- Search ViGene Biosciences for CIAPIN1
CRISPR Products
-
OriGene CRISPR knockouts for CIAPIN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CIAPIN1
- GenScript: Design CRISPR guide RNA sequences for CIAPIN1
miRNA for CIAPIN1 Gene
- miRTarBase miRNAs that target CIAPIN1
-
- hsa-mir-155-5p (MIRT020778)
- hsa-mir-361-3p (MIRT038271)
- hsa-mir-193b-3p (MIRT041489)
- hsa-mir-450a-2-3p (MIRT451529)
- hsa-mir-6857-5p (MIRT451530)
- hsa-mir-6763-5p (MIRT451531)
- hsa-mir-3150a-3p (MIRT451532)
- hsa-mir-6810-5p (MIRT451533)
- hsa-mir-2110 (MIRT451534)
- hsa-mir-1273g-5p (MIRT451535)
- hsa-mir-203a-5p (MIRT451536)
- hsa-mir-92a-1-5p (MIRT451537)
- hsa-mir-486-3p (MIRT451538)
- hsa-mir-4450 (MIRT451539)
- hsa-mir-3202 (MIRT451540)
- hsa-mir-4533 (MIRT451541)
- hsa-mir-222-3p (MIRT451542)
- hsa-mir-221-3p (MIRT451543)
- hsa-mir-548v (MIRT451544)
- hsa-mir-187-5p (MIRT451545)
- hsa-mir-2467-3p (MIRT451546)
- hsa-mir-3179 (MIRT451547)
- hsa-mir-139-5p (MIRT451548)
- hsa-mir-7853-5p (MIRT451549)
- hsa-mir-105-5p (MIRT451550)
- hsa-mir-6805-5p (MIRT451551)
- hsa-mir-6780a-5p (MIRT451552)
- hsa-mir-6779-5p (MIRT451553)
- hsa-mir-3689c (MIRT451554)
- hsa-mir-3689b-3p (MIRT451555)
- hsa-mir-3689a-3p (MIRT451556)
- hsa-mir-30b-3p (MIRT451557)
- hsa-mir-1273h-5p (MIRT451558)
- hsa-mir-525-5p (MIRT451559)
- hsa-mir-520a-5p (MIRT451560)
- hsa-mir-6778-5p (MIRT451561)
- hsa-mir-1233-5p (MIRT451562)
- hsa-mir-6799-5p (MIRT451563)
- hsa-mir-6883-5p (MIRT451564)
- hsa-mir-6785-5p (MIRT451565)
- hsa-mir-4728-5p (MIRT451566)
- hsa-mir-149-3p (MIRT451567)
- hsa-mir-6851-5p (MIRT451568)
- hsa-mir-7106-5p (MIRT451569)
- hsa-mir-3689d (MIRT451570)
- hsa-mir-765 (MIRT451571)
- hsa-mir-505-5p (MIRT451572)
- hsa-mir-6134 (MIRT451573)
- hsa-mir-6847-5p (MIRT451574)
miRNA Products
- Search ViGene Biosciences for CIAPIN1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CIAPIN1
- Browse OriGene Inhibitory RNA Products For CIAPIN1
-
ViGene Biosciences ready-to-package AAV shRNAs for CIAPIN1 gene
Clone Products
-
OriGene ORF clones in human for CIAPIN1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CIAPIN1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CIAPIN1
- VectorBuilder custom plasmid, inducible vectors for CIAPIN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIAPIN1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CIAPIN1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CIAPIN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CIAPIN1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CIAPIN1 Gene
Localization for CIAPIN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CIAPIN1 Gene
- Cytoplasm. Nucleus. Mitochondrion. Mitochondrion intermembrane space. Note=Imported into mitochondria (in vitro).
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 2 |
| extracellular | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IDA | 16957168 |
| GO:0005737 | cytoplasm | ISS,IEA | 14970183 |
| GO:0005739 | mitochondrion | IDA | -- |
Pathways & Interactions for CIAPIN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytosolic iron-sulfur cluster assembly | ||
| 2 | Metabolism |
.37
|
|
Pathways by source for CIAPIN1 Gene
1 GeneTex pathway for CIAPIN1 Gene
2 Reactome pathways for CIAPIN1 Gene
Interacting Proteins for CIAPIN1 Gene
Selected Interacting proteins:
ENSP00000377914
Q6FI81-CPIN1_HUMAN
for CIAPIN1 Gene via
STRING
UniProtKB
IID
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0016226 | iron-sulfur cluster assembly | IBA,IEA | -- |
| GO:0030097 | hemopoiesis | IEA | -- |
| GO:0032259 | methylation | IEA | -- |
No data available for SIGNOR curated interactions for CIAPIN1 Gene
Drugs & Compounds for CIAPIN1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Birinapant (TL32711) | Pharma | Potent XIAP/cIAP1 antagonist | 0 | |||
| BV6 | Pharma | 0 | ||||
| GDC-0152 | Pharma | IAP antagonist,potent amd samll-molecule | 0 | |||
| SM-164 | Pharma | Anticancer agent | 0 | |||
| YM155 | Pharma | Survivin suppressant,apoptosis inhibitor, Survivin inhibitors | 0 |
(5) ApexBio Compounds for CIAPIN1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Birinapant (TL32711) | Potent XIAP/cIAP1 antagonist | 1260251-31-7 |
| BV6 | 1001600-56-1 | |
| GDC-0152 | IAP antagonist,potent amd samll-molecule | 873652-48-3 |
| SM-164 | Anticancer agent | 957135-43-2 |
| YM155 | Survivin suppressant,apoptosis inhibitor | 781661-94-7 |
Drug Products
- ApexBio compounds for CIAPIN1
Transcripts for CIAPIN1 Gene
mRNA/cDNA for CIAPIN1 Gene
- (4) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (262) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CIAPIN1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CIAPIN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CIAPIN1
- GenScript: Design CRISPR guide RNA sequences for CIAPIN1
miRNA Products
- Search ViGene Biosciences for CIAPIN1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CIAPIN1
- Browse OriGene Inhibitory RNA Products For CIAPIN1
-
ViGene Biosciences ready-to-package AAV shRNAs for CIAPIN1 gene
Clone Products
-
OriGene ORF clones in human for CIAPIN1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CIAPIN1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CIAPIN1
- VectorBuilder custom plasmid, inducible vectors for CIAPIN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIAPIN1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||
| SP5: |
Expression for CIAPIN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Intestine (Gastrointestinal Tract)
This gene is overexpressed in Peripheral blood mononuclear cells (15.6), Cervix (6.6), and Lymph node (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CIAPIN1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CIAPIN1 Gene:
CIAPIN1SOURCE GeneReport for Unigene cluster for CIAPIN1 Gene:
Hs.4900mRNA Expression by UniProt/SwissProt for CIAPIN1 Gene:
Q6FI81-CPIN1_HUMAN
Tissue specificity:
Ubiquitously expressed. Highly expressed in heart, liver and pancreas.
Evidence on tissue expression from TISSUES for CIAPIN1 Gene
- Nervous system(4.9)
- Liver(4.2)
- Skin(4.2)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CIAPIN1
-
OriGene qPCR primer pairs for CIAPIN1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIAPIN1 Gene
Orthologs for CIAPIN1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CIAPIN1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CIAPIN1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CIAPIN1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ciapin1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ciapin1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CIAPIN1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | CIAPIN1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ciapin1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398841 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ciapin1 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | DRE2_ANOGA 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | l(2)35Bg 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | T20B12.7 35 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DRE2 35 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G18400 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0674400 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9538 35 |
|
OneToOne |
- Species where no ortholog for CIAPIN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CIAPIN1 Gene
Pseudogenes.org Pseudogenes for CIAPIN1 Gene
No data available for Paralogs for CIAPIN1 Gene
Variants for CIAPIN1 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs538303703 | Likely benign | 57,447,539(+) | TTGGC(C/G/T)GGGCG | upstream-variant-2KB, reference, missense | |
| rs547268811 | Uncertain significance | 57,447,481(+) | GTCGC(C/G/T)GTGGG | upstream-variant-2KB, utr-variant-5-prime | |
| rs886052178 | Uncertain significance | 57,447,469(+) | GCTAC(C/G)GGTCG | upstream-variant-2KB, utr-variant-5-prime | |
| rs886052179 | Uncertain significance | 57,447,587(+) | AGGGG(-/G)CTGCC | intron-variant, upstream-variant-2KB | |
| rs1000369450 | -- | 57,433,737(+) | GAAAC(A/G)TTAAT | intron-variant |
Residual Variation Intolerance Score:
64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.70;
57.30% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CIAPIN1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CIAPIN1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIAPIN1 Gene
Disorders for CIAPIN1 Gene
Relevant External Links for CIAPIN1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CIAPIN1
No disorders were found for CIAPIN1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIAPIN1 Gene
Publications for CIAPIN1 Gene
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3 4 64
- A glutaredoxin-BolA complex serves as an iron-sulfur cluster chaperone for the cytosolic cluster assembly machinery. (PMID: 27519415) Frey A.G. … Philpott C.C. (J. Biol. Chem. 2017) 3 4 64
- Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis. (PMID: 23596212) Banci L. … Winkelmann J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 64
- Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery. (PMID: 21700214) Banci L. … Winkelmann J. (Chem. Biol. 2011) 3 4 64
Products for CIAPIN1 Gene
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- Custom Antibody ServicesOriGene Antibodies for CIAPIN1
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- OriGene Purified Proteins for CIAPIN1
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- OriGene qPCR primer pairs and template standards for CIAPIN1
- OriGene qPCR primer pairs for CIAPIN1
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- GenScript: Design CRISPR guide RNA sequences for CIAPIN1
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- Sino Biological Antibodies
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- Novus Biologicals Antibodies for CIAPIN1
- Novus Biologicals proteins and lysates for CIAPIN1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for CIAPIN1
- Taconic Biosciences Mouse Models for CIAPIN1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CIAPIN1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CIAPIN1
- Addgene plasmids for CIAPIN1
- antibodies-online Antibodies for CIAPIN1: See all 59
- antibodies-online Kits for CIAPIN1: See all 1
- antibodies-online Proteins for CIAPIN1: See all 13
- Search antibodies-online for peptides
- GeneTex CIAPIN1 antibody for CIAPIN1
- Search GeneTex for Proteins for CIAPIN1
- ViGene Biosciences adenoviral particle packaged cDNA for CIAPIN1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CIAPIN1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CIAPIN1 gene
- Search ViGene Biosciences for CIAPIN1
- Santa Cruz Biotechnology (SCBT) Antibodies for CIAPIN1
- Search Santa Cruz Biotechnology (SCBT) for CIAPIN1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CIAPIN1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CIAPIN1
- VectorBuilder custom plasmid, inducible vectors for CIAPIN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CIAPIN1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CIAPIN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer