Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CIAO1 Gene

Aliases for CIAO1 Gene

  • Cytosolic Iron-Sulfur Assembly Component 1 2 3
  • WDR39 3 4 6
  • WD Repeat-Containing Protein 39 3 4
  • WD Repeat Domain 39 2 3
  • Cytosolic Iron-Sulfur Protein Assembly 1 Homolog (S. Cerevisiae) 2
  • Probable Cytosolic Iron-Sulfur Protein Assembly Protein CIAO1 3
  • Cytosolic Iron-Sulfur Protein Assembly 1 Homolog 3
  • Cytosolic Iron-Sulfur Protein Assembly 1 2
  • WD40 Protein Ciao1 3
  • CIA1 3

External Ids for CIAO1 Gene

Previous HGNC Symbols for CIAO1 Gene

  • WDR39

Previous GeneCards Identifiers for CIAO1 Gene

  • GC02P094803
  • GC02P095386
  • GC02P096399
  • GC02P096416
  • GC02P096353
  • GC02P096931
  • GC02P090893

Summaries for CIAO1 Gene

GeneCards Summary for CIAO1 Gene

CIAO1 (Cytosolic Iron-Sulfur Assembly Component 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic Iron-sulfur Cluster Assembly.

UniProtKB/Swiss-Prot for CIAO1 Gene

  • Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Gene Wiki entry for CIAO1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIAO1 Gene

Genomics for CIAO1 Gene

Regulatory Elements for CIAO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CIAO1 Gene

Start:
96,266,132 bp from pter
End:
96,274,179 bp from pter
Size:
8,048 bases
Orientation:
Plus strand

Genomic View for CIAO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIAO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIAO1 Gene

Proteins for CIAO1 Gene

  • Protein details for CIAO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76071-CIAO1_HUMAN
    Recommended name:
    Probable cytosolic iron-sulfur protein assembly protein CIAO1
    Protein Accession:
    O76071
    Secondary Accessions:
    • A0MNN9
    • Q53FM5

    Protein attributes for CIAO1 Gene

    Size:
    339 amino acids
    Molecular mass:
    37840 Da
    Quaternary structure:
    • Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
    Miscellaneous:
    • Ciao means bridge in Chinese

    Three dimensional structures from OCA and Proteopedia for CIAO1 Gene

neXtProt entry for CIAO1 Gene

Proteomics data for CIAO1 Gene at MOPED

Post-translational modifications for CIAO1 Gene

  • Ubiquitination at Lys53
  • Modification sites at PhosphoSitePlus

Other Protein References for CIAO1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CIAO1 Gene

Domains for CIAO1 Gene

Gene Families for CIAO1 Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for CIAO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76071

UniProtKB/Swiss-Prot:

CIAO1_HUMAN :
  • O76071
Family:
  • Belongs to the WD repeat CIA1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with CIAO1: view

Function for CIAO1 Gene

Molecular function for CIAO1 Gene

GENATLAS Biochemistry: functional modulator of the transcriptional activation function Wilms tumor suppressor gene (WT1),ubiquitously expressed,evolutionarily conserved
UniProtKB/Swiss-Prot Function: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Gene Ontology (GO) - Molecular Function for CIAO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CIAO1: view

Animal Model Products

CRISPR Products

miRNA for CIAO1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CIAO1 Gene

Localization for CIAO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIAO1 Gene COMPARTMENTS Subcellular localization image for CIAO1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
extracellular 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CIAO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071817 MMXD complex IDA 20797633
GO:0097361 CIA complex IDA 22678361
genes like me logo Genes that share ontologies with CIAO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CIAO1 Gene

Pathways for CIAO1 Gene

genes like me logo Genes that share pathways with CIAO1: view

Pathways by source for CIAO1 Gene

2 Reactome pathways for CIAO1 Gene

Gene Ontology (GO) - Biological Process for CIAO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9556563
GO:0007059 chromosome segregation IEA --
GO:0008284 positive regulation of cell proliferation TAS 9556563
GO:0016226 iron-sulfur cluster assembly IGI 17937914
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CIAO1: view

Transcripts for CIAO1 Gene

mRNA/cDNA for CIAO1 Gene

Unigene Clusters for CIAO1 Gene

Cytosolic iron-sulfur protein assembly 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIAO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIAO1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5:
SP6: -
SP7:

Relevant External Links for CIAO1 Gene

GeneLoc Exon Structure for
CIAO1
ECgene alternative splicing isoforms for
CIAO1

Expression for CIAO1 Gene

mRNA expression in normal human tissues for CIAO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CIAO1 Gene

SOURCE GeneReport for Unigene cluster for CIAO1 Gene Hs.12109

genes like me logo Genes that share expressions with CIAO1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CIAO1 Gene

Orthologs for CIAO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CIAO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIAO1 35
  • 100 (n)
  • 100 (a)
CIAO1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CIAO1 35
  • 89.48 (n)
  • 93.51 (a)
CIAO1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIAO1 35
  • 92.53 (n)
  • 97.35 (a)
CIAO1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ciao1 35
  • 89.09 (n)
  • 94.99 (a)
Ciao1 16
Ciao1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CIAO1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CIAO1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ciao1 35
  • 89.09 (n)
  • 94.4 (a)
chicken
(Gallus gallus)
Aves CIAO1 35
  • 77.4 (n)
  • 85.62 (a)
CIAO1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ciao1 35
  • 75.08 (n)
  • 82.28 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9607 35
zebrafish
(Danio rerio)
Actinopterygii ciao1 35
  • 72.46 (n)
  • 78.35 (a)
ciao1 36
  • 78 (a)
OneToOne
zgc55911 35
African malaria mosquito
(Anopheles gambiae)
Insecta CIAO1_ANOGA 35
  • 62.08 (n)
  • 59.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ciao1 35
  • 60.86 (n)
  • 59.63 (a)
Ciao1 36
  • 58 (a)
OneToOne
CG12797 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y18D10A.9 35
  • 49.35 (n)
  • 41.94 (a)
Y18D10A.9 36
  • 38 (a)
OneToOne
Y18D10A.9 37
  • 37 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR091W 35
  • 51.01 (n)
  • 43.81 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIA1 35
  • 50.34 (n)
  • 45.58 (a)
CIA1 36
  • 42 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21781g 35
  • 49.47 (n)
  • 43.67 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1345 35
  • 54.72 (n)
  • 52.02 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6887 35
rice
(Oryza sativa)
Liliopsida Os07g0252000 35
  • 55.66 (n)
  • 52.02 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05426 35
  • 52.55 (n)
  • 44.48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13187 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for CIAO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIAO1 Gene

ENSEMBL:
Gene Tree for CIAO1 (if available)
TreeFam:
Gene Tree for CIAO1 (if available)

Paralogs for CIAO1 Gene

Selected SIMAP similar genes for CIAO1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CIAO1: view

No data available for Paralogs for CIAO1 Gene

Variants for CIAO1 Gene

Sequence variations from dbSNP and Humsavar for CIAO1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1044594 -- 96,271,558(+) AACAT(C/G)AGTAC utr-variant-3-prime
rs3087589 -- 96,271,348(+) GGCCT(C/T)TGAGC reference, synonymous-codon
rs3207833 -- 96,273,603(+) GGTTG(C/T)AGTGA utr-variant-3-prime
rs4907309 -- 96,270,516(+) AAAAA(A/T)ACTTT intron-variant
rs6745581 -- 96,269,425(+) CTATG(C/T)AGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIAO1 Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv834305 CNV Gain 17160897
nsv874679 CNV Gain 21882294
nsv508155 CNV Loss 20534489

Relevant External Links for CIAO1 Gene

HapMap Linkage Disequilibrium report
CIAO1
Human Gene Mutation Database (HGMD)
CIAO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIAO1 Gene

Disorders for CIAO1 Gene

No disorders were found for CIAO1 Gene.

No data available for UniProtKB/Swiss-Prot for CIAO1 Gene

Publications for CIAO1 Gene

  1. Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1. (PMID: 9556563) Johnstone R.W. … Shi Y. (J. Biol. Chem. 1998) 2 3 4
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. (PMID: 17937914) Srinivasan V. … Lill R. (Structure 2007) 3 4
  5. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. (PMID: 20797633) Ito S. … Tanaka K. (Mol. Cell 2010) 3 4

Products for CIAO1 Gene

  • Addgene plasmids for CIAO1

Sources for CIAO1 Gene

Back to Top

Content