Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CIAO1 Gene

protein-coding   GIFtS: 56
GCID: GC02P096931

Cytosolic Iron-Sulfur Protein Assembly 1

(Previous names: WD repeat domain 39, cytosolic iron-sulfur protein assembly...)
(Previous symbol: WDR39)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytosolic Iron-Sulfur Protein Assembly 11 2     CIA12
WDR391 2 3 5     Cytosolic Iron-Sulfur Protein Assembly 1 Homolog2
WD Repeat Domain 391 2     Probable Cytosolic Iron-Sulfur Protein Assembly Protein CIAO12
WD Repeat-Containing Protein 392 3     WD40 Protein Ciao12
Cytosolic Iron-Sulfur Protein Assembly 1 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 142801   Entrez Gene: 93912   Ensembl: ENSG000001440217   OMIM: 6043335   UniProtKB: O760713   

Export aliases for CIAO1 gene to outside databases

Previous GC identifers: GC02P094803 GC02P095386 GC02P096399 GC02P096416 GC02P096353 GC02P096295 GC02P090893


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CIAO1 Gene: 
CIAO1 (cytosolic iron-sulfur protein assembly 1) is a protein-coding gene. Diseases associated with CIAO1 include wilms tumor, and kaposi's sarcoma, and among its related super-pathways are Metabolic pathways.

UniProtKB/Swiss-Prot: CIAO1_HUMAN, O76071
Function: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that
mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically
modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play
a role in chromosome segregation

Gene Wiki entry for CIAO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CIAO1 gene promoter:
         GR   E2F-4   E2F-3a   E2F-5   GR-beta   E2F-2   E2F   E2F-1   GR-alpha   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCIAO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CIAO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIAO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.1-q11.2

CIAO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIAO1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P096931:  view genomic region     (about GC identifiers)

Start:
96,931,870 bp from pter      End:
96,939,917 bp from pter
Size:
8,048 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CIAO1_HUMAN, O76071 (See protein sequence)
Recommended Name: Probable cytosolic iron-sulfur protein assembly protein CIAO1  
Size: 339 amino acids; 37840 Da
Subunit: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19
and SLC25A5. Interacts with WT1. Interacts with FAM96A
Miscellaneous: 'Ciao' means 'bridge' in Chinese
1 PDB 3D structure from and Proteopedia for CIAO1:
3FM0 (3D)    
Secondary accessions: A0MNN9 Q53FM5

Explore the universe of human proteins at neXtProt for CIAO1: NX_O76071

Explore proteomics data for CIAO1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O76071

  • CIAO1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CIAO1 Protein Expression
    REFSEQ proteins: NP_004795.1  
    ENSEMBL proteins: 
     ENSP00000418287  
    Reactome Protein details: O76071
    Human Recombinant Protein Products for CIAO1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CIAO1
    OriGene Protein Over-expression Lysate for CIAO1
    OriGene MassSpec for CIAO1 
    OriGene Custom Protein Services for CIAO1
    GenScript Custom Purified and Recombinant Proteins Services for CIAO1
    Novus Biologicals CIAO1 Proteins
    Novus Biologicals CIAO1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CIAO1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0071817MMXD complex IDA--
    GO:0097361CIA complex IDA--

    CIAO1 for ontologies           About GeneDecksing



    CIAO1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CIAO1
    GenScript Custom Superior Antibodies Services for CIAO1
    Novus Biologicals CIAO1 Antibody
    Abcam antibodies for CIAO1
    Cloud-Clone Corp. Antibodies for CIAO1 
    ThermoFisher Antibodies for CIAO1
    LSBio Antibodies in human, mouse, rat for CIAO1 

    Assay Products for CIAO1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CIAO1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CIAO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CIAO1 
    Cloud-Clone Corp. CLIAs for CIAO1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O76071

    ProtoNet protein and cluster: O76071

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: CIAO1_HUMAN, O76071
    Similarity: Belongs to the WD repeat CIA1 family
    Similarity: Contains 7 WD repeats


    CIAO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIAO1_HUMAN, O76071
    Function: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that
    mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically
    modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play
    a role in chromosome segregation

         Genatlas biochemistry entry for CIAO1:
    functional modulator of the transcriptional activation function Wilms tumor suppressor gene (WT1),ubiquitously
    expressed,evolutionarily conserved

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CIAO1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CIAO1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CIAO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIAO1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIAO1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CIAO1:
    hsa-let-7b (MIRT005218)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CIAO1
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CIAO1 (see all 19):
    hsa-miR-623 hsa-miR-200a hsa-miR-138-2* hsa-miR-340 hsa-miR-550a* hsa-miR-1273d hsa-miR-4314 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidCIAO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CIAO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CIAO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CIAO1
    Sirion Biotech Customized adenovirus for overexpression of CIAO1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CIAO1 (see all 8)
    OriGene ORF clones in mouse, rat for CIAO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CIAO1 (NM_004804)
    Sino Biological Human cDNA Clone for CIAO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIAO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIAO1
    Sirion Biotech Customized lentivirus for stable overexpression of CIAO1 
                         Customized lentivirus expression plasmids for stable overexpression of CIAO1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CIAO1
    Search LifeMap BioReagents cell lines for CIAO1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIAO1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CIAO1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    2Cytosolic Iron-sulfur Cluster Assembly
    Cytosolic Iron-sulfur Cluster Assembly

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2        Reactome Pathways for CIAO1
        Cytosolic Iron-sulfur Cluster Assembly
    Metabolism



    CIAO1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CIAO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/84 Interacting proteins for CIAO1 (O760712, 3 ENSP000004182874) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC7Q96M832, 3, ENSP000002776574MINT-66303 I2D: score=4 STRING: ENSP00000277657
    BAG6P463793I2D: score=1 
    ENSG00000096155P463793I2D: score=1 
    ENSG00000227761P463793I2D: score=1 
    ENSG00000228760P463793I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9556563
    GO:0007059chromosome segregation IEA--
    GO:0008284positive regulation of cell proliferation TAS9556563
    GO:0016226iron-sulfur cluster assembly IGI17937914
    GO:0044281small molecule metabolic process TAS--

    CIAO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CIAO1

    Search CenterWatch for drugs/clinical trials and news about CIAO1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CIAO1 gene: 
    NM_004804.2  

    Unigene Cluster for CIAO1:

    Cytosolic iron-sulfur protein assembly 1
    Hs.12109  [show with all ESTs]
    Unigene Representative Sequence: NM_004804
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488633 ENST00000469320 ENST00000272402(uc002svs.3) ENST00000491394

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CIAO1
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CIAO1 (see all 19):
    hsa-miR-623 hsa-miR-200a hsa-miR-138-2* hsa-miR-340 hsa-miR-550a* hsa-miR-1273d hsa-miR-4314 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidCIAO1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CIAO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CIAO1
    Clone
    Products:
         
    OriGene clones in human, mouse for CIAO1 (see all 8)
    OriGene ORF clones in mouse, rat for CIAO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CIAO1 (NM_004804)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIAO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIAO1
    Sirion Biotech Customized lentivirus for stable overexpression of CIAO1 
                         Customized lentivirus expression plasmids for stable overexpression of CIAO1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CIAO1
    OriGene qSTAR qPCR primer pairs in human, mouse for CIAO1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CIAO1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIAO1
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIAO1

    Additional mRNA sequence: 

    AF086118.1 AK056423.1 AK092687.1 AK098406.1 AK124703.1 AK223257.1 AK299503.1 AK315568.1 
    BC001395.2 BC032812.1 CR456802.1 EF011618.1 U63810.1 

    18 DOTS entries:

    DT.316478  DT.100823188  DT.100823179  DT.75188842  DT.97854170  DT.120996302  DT.120996334  DT.91864398 
    DT.120996346  DT.97777837  DT.100666625  DT.100823169  DT.65284707  DT.86858981  DT.95166140  DT.100679351 
    DT.97807769  DT.99965041 

    24/295 AceView cDNA sequences (see all 295):

    BF928848 AI339732 BP343206 BG150053 AV705408 BU158255 BQ894669 AK092687 
    AA304604 BM823662 AW157492 AI678785 BI757061 BM476456 AF086118 BM799740 
    AI634691 BG533301 AA010300 BX419759 BQ212508 CR593125 BM459051 BM769142 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CIAO1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -                                         -           -                     
    SP2:                          -                                         -                                 
    SP3:                          -                                         -     -     -     -               
    SP4:                          -     -                                                                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CIAO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CIAO1 expression in normal human tissues (normalized intensities)      CIAO1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTAAACTCT
    CIAO1 Expression
    About this image


    CIAO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Epidermis (Integumentary System)
             Stratified Epidermis

    See CIAO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CIAO1

    SOURCE GeneReport for Unigene cluster: Hs.12109
        SABiosciences Custom PCR Arrays for CIAO1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CIAO1
    OriGene qSTAR qPCR primer pairs in human, mouse for CIAO1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CIAO1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIAO1
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIAO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIAO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CIAO1 gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ciao11 , 5 cytosolic iron-sulfur protein assembly 1 homolog (S. more5
    cytosolic iron-sulfur protein assembly 11
    89.09(n)1
    94.99(a)1
      2 (61.86 cM)5
    263711  NM_025296.41  NP_079572.21 
     1272409385 
    chicken
    (Gallus gallus)
    Aves CIAO11 cytosolic iron-sulfur protein assembly 1 77.4(n)
    85.62(a)
      426332  XM_423992.3  XP_423992.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL959987.22   -- 79.06(n)    AL959987.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559112 similar to WD40 protein Ciao1 77.11(n)   393116  BC044534.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127973
    Ciao11
    CG12797-PA1 60(a)3
    61.69(n)1
    60.95(a)1
      51C53
    366551  NM_137152.31  NP_610996.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y18D10A.93
    CELE_Y18D10A.91
    WD domain, G-beta repeat3
    Protein Y18D10A.91
    37(a)3
    49.89(n)1
    42.86(a)1
      I(12861246-12866314)3
    1731521  NM_060846.31  NP_493247.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CIA11 Cia1p 50.52(n)
    46.74(a)
      851860   NP_010553.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons emb13451 transducin/WD-40 repeat-containing protein 54.93(n)
    52.02(a)
      817147  NM_128165.3  NP_565615.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g02520001 hypothetical protein 56.11(n)
    52.04(a)
      4342847  NM_001065837.1  NP_001059302.1 


    ENSEMBL Gene Tree for CIAO1 (if available)
    TreeFam Gene Tree for CIAO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/121 SNPs in CIAO1 are shown (see all 121)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470615401,2
    --96933782(+) AAAAAA/GCATTA 1 -- int10--------
    rs599117841,2
    F--96933809(+) AGATCC/TGGCTG 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1477271211,2
    C--96934155(+) GGGCCA/GCACAG 1 -- int10--------
    rs1998319441,2
    --96934303(+) GGAGCG/TTGGCC 2 V L mis10--------
    rs1923146831,2
    C--96934335(+) CTGGCA/GTCTTG 2 A syn10--------
    rs1425221111,2
    C,F--96934352(+) TGACCG/ATACTG 2 /H /R mis11Minor allele frequency- A:0.00NA 4552
    rs1841478891,2
    C--96934377(+) CAGTAC/TCTACC 2 Y syn10--------
    rs1402602701,2
    C--96934388(+) AGGCAA/GTGAAC 2 N S mis11Minor allele frequency- G:0.00EU 1323
    rs621530331,2
    C,F--96934504(+) TGTGCT/CACAAG 1 -- int19Minor allele frequency- C:0.34WA NA CSA EA 369
    rs1412275271,2
    C--96934630(+) GTGAA-/AACTC 
            
    AACAG
    1 -- int10--------

    HapMap Linkage Disequilibrium report for CIAO1 (96931870 - 96939917 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CIAO1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv650e201CNV Deletion23290073
    nsv508155CNV Loss20534489
    nsv874677CNV Loss21882294
    nsv874679CNV Gain21882294
    nsv834305CNV Gain17160897
    esv5003CNV Complex18987735


    Human Gene Mutation Database (HGMD): CIAO1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CIAO1
    DNA2.0 Custom Variant and Variant Library Synthesis for CIAO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604333    OMIM disorders: --

    3 diseases for CIAO1:    About MalaCards
    wilms tumor    kaposi's sarcoma    sarcoma


    CIAO1 for disorders           About GeneDecksing


    Export disorders for CIAO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CIAO1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with CIAO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2, 3 Loftus B.J.... Adams M.D. (1999)
    2. Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1. (PubMed id 9556563)1, 2, 3 Johnstone R.W.... Shi Y. (1998)
    3. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1, 2 Stehling O....Lill R. (2012)
    4. Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. (PubMed id 17937914)1, 2 Srinivasan V.... Lill R. (2007)
    5. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1, 2 Higa L.A.... Zhang H. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. MMS19 links cytoplasmic iron-sulfur cluster assembly t o DNA metabolism. (PubMed id 22678361)2 Gari K....Boulton S.J. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9391 HGNC: 14280 AceView: CIAO1 Ensembl:ENSG00000144021 euGenes: HUgn9391
    ECgene: CIAO1 H-InvDB: CIAO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CIAO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CIAO1 gene:
    Search GeneIP for patents involving CIAO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CIAO1  
     OriGene qPCR primer pairs and template standards for CIAO1   OriGene Protein Over-expression Lysate for CIAO1  
     OriGene MassSpec something-or-other for CIAO1   OriGene clones in human, mouse for CIAO1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CIAO1   OriGene Purified Protein for CIAO1  
     OriGene ORF clones in mouse, rat for CIAO1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CIAO1   OriGene Custom Protein Services for CIAO1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CIAO1
     QIAGEN SeqTarget long-range PCR primers for resequencing CIAO1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIAO1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CIAO1
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIAO1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIAO1
     GenScript Custom Purified and Recombinant Proteins Services for CIAO1 GenScript cDNA clones with any tag delivered in your preferred vector for CIAO1
     GenScript Custom Assay Services for CIAO1 GenScript Custom Superior Antibodies Services for CIAO1
     GenScript Custom overexpressing Cell Line Services for CIAO1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CIAO1 promoter
     Search Chromatin IP Primers for CIAO1
     RT2 qPCR Primer Assay in human, mouse, rat CIAO1
     Search GNC Networks for CIAO1
     SABiosciences Custom PCR Arrays for CIAO1
     Search Tocris compounds for CIAO1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CIAO1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CIAO1 antibodies
     CIAO1 proteins
     CIAO1 lysates
     Antibodies for CIAO1
     See all of Abcam's Antibodies, Kits and Proteins for CIAO1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CIAO1
     Antibodies for CIAO1
     ELISAs for CIAO1
     CLIAs for CIAO1
     Search LifeMap BioReagents cell lines for CIAO1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIAO1
     SwitchGear 3'UTR luciferase reporter plasmids for CIAO1
     SwitchGear Promoter luciferase reporter plasmids for CIAO1
     ThermoFisher Antibodies for CIAO1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIAO1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CIAO1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CIAO1
    Customized:
     lentivirus for stable overexpression of CIAO1
     lentivirus expression plasmids for stable overexpression of CIAO1
     adenovirus for overexpression of CIAO1
     LSBio Antibodies in human, mouse, rat for CIAO1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CIAO1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4