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Aliases for CHURC1-FNTB Gene

Aliases for CHURC1-FNTB Gene

  • CHURC1-FNTB Readthrough 2 3 5

External Ids for CHURC1-FNTB Gene

Previous GeneCards Identifiers for CHURC1-FNTB Gene

  • GC14U901261
  • GC14P065384
  • GC14P065385

Summaries for CHURC1-FNTB Gene

Entrez Gene Summary for CHURC1-FNTB Gene

  • This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for CHURC1-FNTB Gene

CHURC1-FNTB (CHURC1-FNTB Readthrough) is a Protein Coding gene. An important paralog of this gene is FNTB.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHURC1-FNTB Gene

Genomics for CHURC1-FNTB Gene

Regulatory Elements for CHURC1-FNTB Gene

Enhancers for CHURC1-FNTB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CHURC1-FNTB on UCSC Golden Path with GeneCards custom track

Promoters for CHURC1-FNTB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHURC1-FNTB on UCSC Golden Path with GeneCards custom track

Genomic Location for CHURC1-FNTB Gene

Chromosome:
14
Start:
64,914,361 bp from pter
End:
65,062,655 bp from pter
Size:
148,295 bases
Orientation:
Plus strand

Genomic View for CHURC1-FNTB Gene

Genes around CHURC1-FNTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHURC1-FNTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHURC1-FNTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHURC1-FNTB Gene

Proteins for CHURC1-FNTB Gene

  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    B4DL54
    Recommended name:
    Protein CHURC1-FNTB
    Protein Accession:
    B4DL54
    Secondary Accessions:
    • H0YHI0

    Protein attributes for CHURC1-FNTB Gene

    Size:
    471 amino acids
    Molecular mass:
    52785 Da
    Quaternary structure:
    No Data Available
  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YIM3
    Recommended name:
    Protein CHURC1-FNTB
    Protein Accession:
    H0YIM3

    Protein attributes for CHURC1-FNTB Gene

    Size:
    107 amino acids
    Molecular mass:
    12015 Da
    Quaternary structure:
    No Data Available
  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YIM9
    Recommended name:
    Protein CHURC1-FNTB
    Protein Accession:
    H0YIM9

    Protein attributes for CHURC1-FNTB Gene

    Size:
    85 amino acids
    Molecular mass:
    9824 Da
    Quaternary structure:
    No Data Available
  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YJ25
    Recommended name:
    Protein CHURC1-FNTB
    Protein Accession:
    H0YJ25

    Protein attributes for CHURC1-FNTB Gene

    Size:
    69 amino acids
    Molecular mass:
    8074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHURC1-FNTB Gene

Proteomics data for CHURC1-FNTB Gene at MOPED

Post-translational modifications for CHURC1-FNTB Gene

No Post-translational modifications

Other Protein References for CHURC1-FNTB Gene

No data available for DME Specific Peptides for CHURC1-FNTB Gene

Domains & Families for CHURC1-FNTB Gene

Protein Domains for CHURC1-FNTB Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHURC1-FNTB: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CHURC1-FNTB Gene

Function for CHURC1-FNTB Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHURC1-FNTB Gene

Localization for CHURC1-FNTB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHURC1-FNTB Gene COMPARTMENTS Subcellular localization image for CHURC1-FNTB gene
Compartment Confidence
cytosol 5
cytoskeleton 4
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CHURC1-FNTB Gene

Pathways & Interactions for CHURC1-FNTB Gene

SuperPathways for CHURC1-FNTB Gene

No Data Available

Interacting Proteins for CHURC1-FNTB Gene

Gene Ontology (GO) - Biological Process for CHURC1-FNTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CHURC1-FNTB: view

No data available for Pathways by source and SIGNOR curated interactions for CHURC1-FNTB Gene

Drugs & Compounds for CHURC1-FNTB Gene

No Compound Related Data Available

Transcripts for CHURC1-FNTB Gene

mRNA/cDNA for CHURC1-FNTB Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CHURC1-FNTB Gene

No ASD Table

Relevant External Links for CHURC1-FNTB Gene

GeneLoc Exon Structure for
CHURC1-FNTB
ECgene alternative splicing isoforms for
CHURC1-FNTB

Expression for CHURC1-FNTB Gene

mRNA expression in normal human tissues for CHURC1-FNTB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB for CHURC1-FNTB Gene



genes like me logo Genes that share expression patterns with CHURC1-FNTB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CHURC1-FNTB Gene

Orthologs for CHURC1-FNTB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHURC1-FNTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNTB 35
  • 99.93 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia FNTB 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fntb 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17565 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fntb-1 36
  • 43 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR275W 35
  • 48.98 (n)
  • 41.16 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07161g 35
  • 45.4 (n)
  • 40.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAM1 35
  • 46.35 (n)
  • 42.7 (a)
RAM1 36
  • 35 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU05999 35
  • 50.38 (n)
  • 45.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cpp1 35
  • 44.73 (n)
  • 42.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for CHURC1-FNTB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CHURC1-FNTB Gene

ENSEMBL:
Gene Tree for CHURC1-FNTB (if available)
TreeFam:
Gene Tree for CHURC1-FNTB (if available)

Paralogs for CHURC1-FNTB Gene

Paralogs for CHURC1-FNTB Gene

(2) SIMAP similar genes for CHURC1-FNTB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHURC1-FNTB: view

Variants for CHURC1-FNTB Gene

Sequence variations from dbSNP and Humsavar for CHURC1-FNTB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2737851 -- 64,937,352(-) TTAGA(A/G)CCTGA intron-variant
rs2737852 -- 64,937,315(-) TCCCT(G/T)GAGGC intron-variant
rs2763890 -- 64,937,397(-) AACAG(A/G)GCCAG intron-variant
rs7144331 -- 64,983,078(+) ggagg(G/T)agctg intron-variant
rs3742599 -- 64,945,190(-) ACCCA(G/T)GTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHURC1-FNTB Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
esv33119 CNV Gain 17666407
esv21993 CNV Gain 19812545
nsv832816 CNV Gain 17160897
esv2506970 CNV Deletion 19546169
esv2748787 CNV Deletion 23290073
esv2665422 CNV Deletion 23128226

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for CHURC1-FNTB Gene

Disorders for CHURC1-FNTB Gene

Relevant External Links for CHURC1-FNTB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHURC1-FNTB

No disorders were found for CHURC1-FNTB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHURC1-FNTB Gene

Publications for CHURC1-FNTB Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 67
  2. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans D.M. … Whitfield J.B. (Hum. Mol. Genet. 2013) 3
  3. Seventy-five genetic loci influencing the human red blood cell. (PMID: 23222517) van der Harst P. … Chambers J.C. (Nature 2012) 3
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh S.K. … Lin J.P. (Nat. Genet. 2009) 3

Products for CHURC1-FNTB Gene

Sources for CHURC1-FNTB Gene

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