CHURC1-FNTB Gene
protein-coding GIFtS: 26
GCID: GC14P065384
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CHURC1-FNTB readthrough
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Aliases
for CHURC1-FNTB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CHURC1-FNTB Readthrough1 2 | | CHURC1-FNTB Protein2 | | CDNA FLJ35979 Fis, Clone TESTI2013545, Highly Similar To ProteinFarnesyltransferase Subunit Beta (EC 2.5.1.58)4 | | CDNA FLJ58825, Highly Similar To Protein Farnesyltransferase Subunit Beta (EC2.5.1.58)4 | | CDNA FLJ59570, Highly Similar To Protein Farnesyltransferase Subunit Beta (EC2.5.1.58)4 |
Export aliases for CHURC1-FNTB gene to outside databasesPrevious GC identifer: GC14U901261 |
Summaries
for CHURC1-FNTB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHURC1-FNTB:
This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domaincontaining 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces afusion protein that shares sequence identity with each individual gene product. (provided by RefSeq, Feb 2011)
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Genomic Views
for CHURC1-FNTB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CHURC1-FNTB
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHURC1-FNTB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHURC1-FNTB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q23 Ensembl cytogenetic band: 14q23.3 HGNC cytogenetic band: 14q23.3CHURC1-FNTB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P065384: view genomic region
(about GC identifiers)
Start:
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65,381,203 bp from pter |
End:
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65,529,368 bp from pter |
Size:
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148,166 bases |
Orientation:
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plus strand |
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Proteins
for CHURC1-FNTB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/TrEMBL: B3KSC2 (See
protein sequence)Recommended Name: Protein CHURC1-FNTB Size: 193 amino acids; 21429 DaUniProtKB/TrEMBL: B4DL54 (See
protein sequence) Recommended Name: Protein CHURC1-FNTB Size: 471 amino acids; 52785 DaUniProtKB/TrEMBL: B4E1A0 (See
protein sequence) Recommended Name: Protein CHURC1-FNTB Size: 391 amino acids; 43574 DaUniProtKB/TrEMBL: H0YHI0 (See
protein sequence) Recommended Name: Protein CHURC1-FNTB Size: 472 amino acids; 52856 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataUniProtKB/TrEMBL: H0YIM3 (See
protein sequence) Recommended Name: Protein CHURC1-FNTB Size: 107 amino acids; 12015 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataUniProtKB/TrEMBL: H0YIM9 (See
protein sequence) Recommended Name: Protein CHURC1-FNTB Size: 85 amino acids; 9824 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataUniProtKB/TrEMBL: H0YJ25 (See
protein sequence) Recommended Name: Protein CHURC1-FNTB Size: 69 amino acids; 8074 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataCHURC1-FNTB Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (2 alternative transcripts):
NP_001189487.1 NP_001189488.1
ENSEMBL proteins: ENSP00000449668 ENSP00000447121 ENSP00000450692 ENSP00000449709 ENSP00000406393 ENSP00000443140 ENSP00000399362
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0043234 | protein complex |
-- | -- |
CHURC1-FNTB for ontologies About GeneDecksing
CHURC1-FNTB Antibody Products:
Assay Products for CHURC1-FNTB: |
Protein
Domains /
Families
for CHURC1-FNTB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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CHURC1-FNTB for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry B3KSC2Graphical View of Domain Structure for InterPro Entry B4DL54Graphical View of Domain Structure for InterPro Entry B4E1A0Graphical View of Domain Structure for InterPro Entry H0YHI0Graphical View of Domain Structure for InterPro Entry H0YIM3Graphical View of Domain Structure for InterPro Entry H0YIM9Graphical View of Domain Structure for InterPro Entry H0YJ25ProtoNet protein and cluster: B3KSC2 |
Function
for CHURC1-FNTB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHURC1-FNTB |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
CHURC1-FNTB for ontologies About GeneDecksing
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Pathways & Interactions
for CHURC1-FNTB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHURC1-FNTB
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
-- | -- | | GO:0008285 | negative regulation of cell proliferation |
-- | -- | | GO:0010035 | response to inorganic substance |
-- | -- | | GO:0014070 | response to organic cyclic compound |
-- | -- | | GO:0034097 | response to cytokine stimulus |
-- | -- |
CHURC1-FNTB for ontologies About GeneDecksing
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Drugs & Compounds
for CHURC1-FNTB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for CHURC1-FNTB
Search CenterWatch for drugs/clinical trials and news about CHURC1-FNTB 
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Transcripts
for CHURC1-FNTB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for CHURC1-FNTB gene (2 alternative transcripts): NM_001202558.1 NM_001202559.1 7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000552941 ENST00000549987 ENST00000553743 ENST00000551823 ENST00000447296
ENST00000542227 ENST00000448390(uc001xid.3 uc010tso.2)
GeneLoc Exon Structure
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Expression
for CHURC1-FNTB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHURC1-FNTB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for CHURC1-FNTB
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CHURC1-FNTB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHURC1-FNTB | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHURC1-FNTB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHURC1-FNTB |
Orthologs
for CHURC1-FNTB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for CHURC1-FNTB gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
FNTB6 |
-- |
84(a) |
1 → many |
1(93647375-93662482) |
zebrafish
(Danio rerio) |
Actinopterygii |
fntb6 |
farnesyltransferase, CAAX box, beta |
65(a) |
1 → many |
20(28829892-28853668) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG175656 |
-- |
46(a) |
1 → many |
3R(12258703-12260462) |
worm
(Caenorhabditis elegans) |
Secernentea |
fntb-16 |
Temporarily Assigned Gene name family member (tag-... |
42(a) |
1 → many |
V(14447636-14449576) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ERA16 |
protein farnesyltransferase subunit beta |
37(a) |
1 → many |
5(16101391-16104961) |
rice
(Oryza sativa) |
Liliopsida |
-- |
farnesyltransferase subunit beta, putative, expres... |
38(a) |
1 → many |
1(30774058-30778229) |
ENSEMBL Gene Tree for CHURC1-FNTB (if available)
TreeFam Gene Tree for CHURC1-FNTB (if available) |
Paralogs
for CHURC1-FNTB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHURC1-FNTB gene
- FNTB2
3 SIMAP similar genes for CHURC1-FNTB using alignment to 7 protein entries: B3KSC2_HUMAN (see all proteins):CHURC1 FNTB RABGGTB
CHURC1-FNTB for paralogs About GeneDecksing
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Genomic Variants
for CHURC1-FNTB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHURC1-FNTB (65381203 - 65529368 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHURC1-FNTB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHURC1-FNTB |
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Disorders
/ Diseases
for CHURC1-FNTB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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CHURC1-FNTB for disorders About GeneDecksing
1  disease for CHURC1-FNTB: About MalaCardsmalaria
Export disorders for CHURC1-FNTB gene to outside databases
|
Publications
for CHURC1-FNTB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHURC1-FNTB gene integrated from 9 sources:
(articles sorted by number of sources associating them with CHURC1-FNTB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
- Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1 Ganesh S.K....Lin J.P. (2009)
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External Searches for CHURC1-FNTB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CHURC1-FNTB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHURC1-FNTB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHURC1-FNTB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CHURC1-FNTB gene:
Search GeneIP for patents involving CHURC1-FNTB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHURC1-FNTB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHURC1-FNTB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHURC1-FNTB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHURC1-FNTB | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHURC1-FNTB | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHURC1-FNTB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHURC1-FNTB |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHURC1-FNTB |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CHURC1-FNTB |
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