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Aliases for CHURC1-FNTB Gene

Aliases for CHURC1-FNTB Gene

  • CHURC1-FNTB Readthrough 2 3 5

External Ids for CHURC1-FNTB Gene

Previous GeneCards Identifiers for CHURC1-FNTB Gene

  • GC14U901261
  • GC14P065384
  • GC14P065385

Summaries for CHURC1-FNTB Gene

Entrez Gene Summary for CHURC1-FNTB Gene

  • This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for CHURC1-FNTB Gene

CHURC1-FNTB (CHURC1-FNTB Readthrough) is a Protein Coding gene. An important paralog of this gene is FNTB.

Additional gene information for CHURC1-FNTB Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHURC1-FNTB Gene

Genomics for CHURC1-FNTB Gene

Regulatory Elements for CHURC1-FNTB Gene

Enhancers for CHURC1-FNTB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H064754 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -156.7 -156662 5 KLF17 RAD21 GLIS2 ZNF143 RCOR1 FOS DEK ZNF654 USF2 CEBPB CHURC1 PLEKHG3 PPP1R36 RPPH1-2P CHURC1-FNTB GPX2 SPTB ZBTB1 PIR60020 GC14P064746
GH14H065042 1.5 Ensembl ENCODE dbSUPER 11.6 +129.5 129500 3 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 RUNX3 NCOA1 FNTB CHURC1-FNTB CHURC1 MIR4706 PIR35799
GH14H064822 1.4 Ensembl ENCODE dbSUPER 11.1 -88.2 -88182 7 PKNOX1 ZNF2 RAD21 TCF12 GLIS2 ZNF143 FOS CREM SMARCA5 ZNF654 CHURC1 SPTB RPPH1-2P CHURC1-FNTB GPX2 RAB15 PIR49393 GC14M064872
GH14H065078 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +167.2 167186 6 SREBF1 IRF2 FOXA2 STAT1 IKZF1 STAT2 HNF4A MLLT1 CHURC1-FNTB RAB15 FNTB LOC100506321 PIR44037
GH14H064937 1.3 Ensembl ENCODE 11.4 +26.6 26646 6 FOXA2 MLX ARID4B DMAP1 YY1 TCF12 PAF1 SP5 MXD4 REST CHURC1 CHURC1-FNTB RPPH1-2P RAB15 SPTB GC14M064940 GPX2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHURC1-FNTB on UCSC Golden Path with GeneCards custom track

Promoters for CHURC1-FNTB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069690 240 1600 PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 ELK1

Genomic Location for CHURC1-FNTB Gene

Chromosome:
14
Start:
64,914,361 bp from pter
End:
65,062,655 bp from pter
Size:
148,295 bases
Orientation:
Plus strand

Genomic View for CHURC1-FNTB Gene

Genes around CHURC1-FNTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHURC1-FNTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHURC1-FNTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHURC1-FNTB Gene

Proteins for CHURC1-FNTB Gene

  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    B4DL54
    Recommended name:
    CHURC1-FNTB readthrough
    Protein Accession:
    B4DL54
    Secondary Accessions:
    • H0YHI0

    Protein attributes for CHURC1-FNTB Gene

    Size:
    471 amino acids
    Molecular mass:
    52785 Da
    Quaternary structure:
    No Data Available
  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YIM3
    Recommended name:
    CHURC1-FNTB readthrough
    Protein Accession:
    H0YIM3

    Protein attributes for CHURC1-FNTB Gene

    Size:
    107 amino acids
    Molecular mass:
    12015 Da
    Quaternary structure:
    No Data Available
  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YIM9
    Recommended name:
    CHURC1-FNTB readthrough
    Protein Accession:
    H0YIM9

    Protein attributes for CHURC1-FNTB Gene

    Size:
    85 amino acids
    Molecular mass:
    9824 Da
    Quaternary structure:
    No Data Available
  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YJ25
    Recommended name:
    CHURC1-FNTB readthrough
    Protein Accession:
    H0YJ25

    Protein attributes for CHURC1-FNTB Gene

    Size:
    69 amino acids
    Molecular mass:
    8074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHURC1-FNTB Gene

Post-translational modifications for CHURC1-FNTB Gene

No Post-translational modifications

Other Protein References for CHURC1-FNTB Gene

No data available for DME Specific Peptides for CHURC1-FNTB Gene

Domains & Families for CHURC1-FNTB Gene

Gene Families for CHURC1-FNTB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CHURC1-FNTB Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHURC1-FNTB: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CHURC1-FNTB Gene

Function for CHURC1-FNTB Gene

Phenotypes From GWAS Catalog for CHURC1-FNTB Gene

Gene Ontology (GO) - Molecular Function for CHURC1-FNTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004660 protein farnesyltransferase activity IBA --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CHURC1-FNTB: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for CHURC1-FNTB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHURC1-FNTB Gene

Localization for CHURC1-FNTB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHURC1-FNTB gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CHURC1-FNTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005965 protein farnesyltransferase complex IBA --
genes like me logo Genes that share ontologies with CHURC1-FNTB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CHURC1-FNTB Gene

Pathways & Interactions for CHURC1-FNTB Gene

SuperPathways for CHURC1-FNTB Gene

No Data Available

Interacting Proteins for CHURC1-FNTB Gene

Gene Ontology (GO) - Biological Process for CHURC1-FNTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0018343 protein farnesylation IBA --
GO:0042127 regulation of cell proliferation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CHURC1-FNTB: view

No data available for Pathways by source and SIGNOR curated interactions for CHURC1-FNTB Gene

Drugs & Compounds for CHURC1-FNTB Gene

No Compound Related Data Available

Transcripts for CHURC1-FNTB Gene

mRNA/cDNA for CHURC1-FNTB Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for CHURC1-FNTB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CHURC1-FNTB Gene

No ASD Table

Relevant External Links for CHURC1-FNTB Gene

GeneLoc Exon Structure for
CHURC1-FNTB
ECgene alternative splicing isoforms for
CHURC1-FNTB

Expression for CHURC1-FNTB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHURC1-FNTB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for CHURC1-FNTB Gene



Evidence on tissue expression from TISSUES for CHURC1-FNTB Gene

  • Nervous system(4.8)
  • Skin(4.1)
  • Kidney(3.1)
  • Lung(2.8)
  • Intestine(2.6)
  • Pancreas(2.5)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with CHURC1-FNTB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHURC1-FNTB Gene

Orthologs for CHURC1-FNTB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHURC1-FNTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNTB 33
  • 99.93 (n)
cow
(Bos Taurus)
Mammalia FNTB 34
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 78 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fntb 34
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17565 34
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fntb-1 34
  • 43 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR275W 33
  • 48.98 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAM1 33 34
  • 46.35 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07161g 33
  • 45.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU05999 33
  • 50.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cpp1 33
  • 44.73 (n)
Species where no ortholog for CHURC1-FNTB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CHURC1-FNTB Gene

ENSEMBL:
Gene Tree for CHURC1-FNTB (if available)
TreeFam:
Gene Tree for CHURC1-FNTB (if available)

Paralogs for CHURC1-FNTB Gene

Paralogs for CHURC1-FNTB Gene

(2) SIMAP similar genes for CHURC1-FNTB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHURC1-FNTB: view

Variants for CHURC1-FNTB Gene

Sequence variations from dbSNP and Humsavar for CHURC1-FNTB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000004753 -- 64,997,092(+) ATGGT(C/T)GTAAT intron-variant
rs1000009374 -- 65,039,915(+) CAAGT(A/G)CGGTG intron-variant
rs1000009500 -- 64,963,830(+) TCCCC(A/C)ACACC intron-variant
rs1000029483 -- 65,011,742(+) AGGAC(A/T)GCGAC intron-variant
rs1000089134 -- 65,059,550(+) AATTA(-/TTGTT)TTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHURC1-FNTB Gene

Variant ID Type Subtype PubMed ID
esv21993 CNV gain 19812545
esv2506970 CNV deletion 19546169
esv2665422 CNV deletion 23128226
esv2748779 CNV deletion 23290073
esv2748787 CNV deletion 23290073
esv33119 CNV gain 17666407
esv3551663 CNV deletion 23714750
esv3634758 CNV loss 21293372
nsv1070225 CNV deletion 25765185
nsv1071152 CNV deletion 25765185
nsv1108903 CNV deletion 24896259
nsv1121874 CNV deletion 24896259
nsv832816 CNV gain 17160897

Relevant External Links for CHURC1-FNTB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHURC1-FNTB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CHURC1-FNTB Gene

Disorders for CHURC1-FNTB Gene

Relevant External Links for CHURC1-FNTB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHURC1-FNTB

No disorders were found for CHURC1-FNTB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHURC1-FNTB Gene

Publications for CHURC1-FNTB Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  2. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans DM … Whitfield JB (Human molecular genetics 2013) 3 60
  3. Seventy-five genetic loci influencing the human red blood cell. (PMID: 23222517) van der Harst P … Chambers JC (Nature 2012) 3 60
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60
  5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh SK … Lin JP (Nature genetics 2009) 3 60

Products for CHURC1-FNTB Gene

Sources for CHURC1-FNTB Gene

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