Aliases for CHURC1-FNTB Gene
External Ids for CHURC1-FNTB Gene
- HGNC: 42960
- Entrez Gene: 100529261
- Ensembl: ENSG00000125954
Previous GeneCards Identifiers for CHURC1-FNTB Gene
- GC14U901261
- GC14P065384
- GC14P065385
Summaries for CHURC1-FNTB Gene
-
This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
GeneCards Summary for CHURC1-FNTB Gene
CHURC1-FNTB (CHURC1-FNTB Readthrough) is a Protein Coding gene. An important paralog of this gene is FNTB.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHURC1-FNTB Gene
Genomics for CHURC1-FNTB Gene
Regulatory Elements for CHURC1-FNTB Gene
Enhancers for CHURC1-FNTB Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CHURC1-FNTB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CHURC1-FNTB Gene
- Chromosome:
- 14
- Start:
- 64,914,361 bp from pter
- End:
- 65,062,655 bp from pter
- Size:
- 148,295 bases
- Orientation:
- Plus strand
Genomic View for CHURC1-FNTB Gene
Genes around CHURC1-FNTB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q23.3 by Ensembl
- 14q23.3 by Entrez Gene
- 14q23.3 by HGNC
CHURC1-FNTB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHURC1-FNTB Gene
Proteins for CHURC1-FNTB Gene
-
Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- B4DL54
- Recommended name:
- CHURC1-FNTB readthrough
- Protein Accession:
- B4DL54
- H0YHI0
Protein attributes for CHURC1-FNTB Gene
- Size:
- 471 amino acids
- Molecular mass:
- 52785 Da
- Quaternary structure:
- No Data Available
-
Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H0YIM3
- Recommended name:
- CHURC1-FNTB readthrough
- Protein Accession:
- H0YIM3
Protein attributes for CHURC1-FNTB Gene
- Size:
- 107 amino acids
- Molecular mass:
- 12015 Da
- Quaternary structure:
- No Data Available
-
Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H0YIM9
- Recommended name:
- CHURC1-FNTB readthrough
- Protein Accession:
- H0YIM9
Protein attributes for CHURC1-FNTB Gene
- Size:
- 85 amino acids
- Molecular mass:
- 9824 Da
- Quaternary structure:
- No Data Available
-
Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H0YJ25
- Recommended name:
- CHURC1-FNTB readthrough
- Protein Accession:
- H0YJ25
Protein attributes for CHURC1-FNTB Gene
- Size:
- 69 amino acids
- Molecular mass:
- 8074 Da
- Quaternary structure:
- No Data Available
Protein Expression for CHURC1-FNTB Gene
Post-translational modifications for CHURC1-FNTB Gene
No Post-translational modifications
Other Protein References for CHURC1-FNTB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for CHURC1-FNTB
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CHURC1-FNTB
- Origene Custom Protein Services for CHURC1-FNTB
- Search GeneTex for Proteins for CHURC1-FNTB
Assay Products
No data available for DME Specific Peptides for CHURC1-FNTB Gene
Domains & Families for CHURC1-FNTB Gene
Protein Domains for CHURC1-FNTB Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CHURC1-FNTB Gene
Function for CHURC1-FNTB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004660 | protein farnesyltransferase activity | IBA | -- |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHURC1-FNTB
-
-
ViGene Biosciences ready-to-package AAV shRNAs for CHURC1-FNTB gene
- Search ViGene Biosciences for CHURC1-FNTB
CRISPR Products
- Browse CRISPR knockouts for CHURC1-FNTB
miRNA Products
- Search ViGene Biosciences for CHURC1-FNTB
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for CHURC1-FNTB gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CHURC1-FNTB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHURC1-FNTB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CHURC1-FNTB
-
ViGene Biosciences adenoviral particle packaged cDNA for CHURC1-FNTB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHURC1-FNTB gene
- Search ViGene Biosciences for CHURC1-FNTB
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHURC1-FNTB Gene
Localization for CHURC1-FNTB Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005965 | protein farnesyltransferase complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CHURC1-FNTB Gene
Pathways & Interactions for CHURC1-FNTB Gene
No Data Available
Interacting Proteins for CHURC1-FNTB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0018343 | protein farnesylation | IEA | -- |
| GO:0042127 | regulation of cell proliferation | IEA | -- |
| GO:0045893 | positive regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CHURC1-FNTB Gene
Transcripts for CHURC1-FNTB Gene
mRNA/cDNA for CHURC1-FNTB Gene
- (2) REFSEQ mRNAs :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for CHURC1-FNTB
miRNA Products
- Search ViGene Biosciences for CHURC1-FNTB
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for CHURC1-FNTB gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CHURC1-FNTB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHURC1-FNTB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Relevant External Links for CHURC1-FNTB Gene
- GeneLoc Exon Structure for
- CHURC1-FNTB
- ECgene alternative splicing isoforms for
- CHURC1-FNTB
Expression for CHURC1-FNTB Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for CHURC1-FNTB Gene
Evidence on tissue expression from TISSUES for CHURC1-FNTB Gene
- Nervous system(4.8)
- Skin(4.1)
- Kidney(3.1)
- Lung(2.8)
- Intestine(2.6)
- Pancreas(2.5)
- Eye(2.2)
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHURC1-FNTB Gene
Orthologs for CHURC1-FNTB Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FNTB 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FNTB 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | fntb 35 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG17565 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | fntb-1 35 |
|
OneToMany | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR275W 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAM1 34 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F07161g 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU05999 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cpp1 34 |
|
- Species where no ortholog for CHURC1-FNTB was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for CHURC1-FNTB Gene
- ENSEMBL:
- Gene Tree for CHURC1-FNTB (if available)
- TreeFam:
- Gene Tree for CHURC1-FNTB (if available)
Paralogs for CHURC1-FNTB Gene
(2) SIMAP similar genes for CHURC1-FNTB Gene using alignment to 4 proteins:
Variants for CHURC1-FNTB Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004753 | -- | 64,997,092(+) | ATGGT(C/T)GTAAT | intron-variant | |
| rs1000009374 | -- | 65,039,915(+) | CAAGT(A/G)CGGTG | intron-variant | |
| rs1000009500 | -- | 64,963,830(+) | TCCCC(A/C)ACACC | intron-variant | |
| rs1000029483 | -- | 65,011,742(+) | AGGAC(A/T)GCGAC | intron-variant | |
| rs1000089134 | -- | 65,059,550(+) | AATTA(-/TTGTT)TTATC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv21993 | CNV | gain | 19812545 |
| esv2506970 | CNV | deletion | 19546169 |
| esv2665422 | CNV | deletion | 23128226 |
| esv2748779 | CNV | deletion | 23290073 |
| esv2748787 | CNV | deletion | 23290073 |
| esv33119 | CNV | gain | 17666407 |
| esv3551663 | CNV | deletion | 23714750 |
| esv3634758 | CNV | loss | 21293372 |
| nsv1070225 | CNV | deletion | 25765185 |
| nsv1071152 | CNV | deletion | 25765185 |
| nsv1108903 | CNV | deletion | 24896259 |
| nsv1121874 | CNV | deletion | 24896259 |
| nsv832816 | CNV | gain | 17160897 |
Relevant External Links for CHURC1-FNTB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CHURC1-FNTB
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CHURC1-FNTB Gene
Disorders for CHURC1-FNTB Gene
Relevant External Links for CHURC1-FNTB
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CHURC1-FNTB
No disorders were found for CHURC1-FNTB Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHURC1-FNTB Gene
Publications for CHURC1-FNTB Gene
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
- Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans D.M. … Whitfield J.B. (Hum. Mol. Genet. 2013) 3 64
- Seventy-five genetic loci influencing the human red blood cell. (PMID: 23222517) van der Harst P. … Chambers J.C. (Nature 2012) 3 64
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
- Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh S.K. … Lin J.P. (Nat. Genet. 2009) 3 64
Products for CHURC1-FNTB Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse OriGene qPCR primer pairs and template standards
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- GenScript: Next-day shipping cDNA ORF clone for CHURC1-FNTB in any vector
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for CHURC1-FNTB gene
- ViGene Biosciences ready-to-package AAV shRNAs for CHURC1-FNTB gene
- Search ViGene Biosciences for CHURC1-FNTB
- Horizon Cell Lines for CHURC1-FNTB
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHURC1-FNTB
- VectorBuilder custom plasmid, inducible vectors for CHURC1-FNTB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHURC1-FNTB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CHURC1-FNTB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (147) VectorBuilder
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- (151) CIViC
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer