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Aliases for CHURC1-FNTB Gene

Aliases for CHURC1-FNTB Gene

  • CHURC1-FNTB Readthrough 2 3

External Ids for CHURC1-FNTB Gene

Previous GeneCards Identifiers for CHURC1-FNTB Gene

  • GC14U901261
  • GC14P065384
  • GC14P065385

Summaries for CHURC1-FNTB Gene

Entrez Gene Summary for CHURC1-FNTB Gene

  • This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for CHURC1-FNTB Gene

CHURC1-FNTB (CHURC1-FNTB Readthrough) is a Protein Coding gene. An important paralog of this gene is FNTB.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHURC1-FNTB Gene

Genomics for CHURC1-FNTB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHURC1-FNTB Gene

Start:
64,914,361 bp from pter
End:
65,062,655 bp from pter
Size:
148,295 bases
Orientation:
Plus strand

Genomic View for CHURC1-FNTB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHURC1-FNTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHURC1-FNTB Gene

No data available for Regulatory Elements for CHURC1-FNTB Gene

Proteins for CHURC1-FNTB Gene

  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    B4DL54
    Recommended name:
    Protein CHURC1-FNTB
    Protein Accession:
    B4DL54
    Secondary Accessions:
    • H0YHI0

    Protein attributes for CHURC1-FNTB Gene

    Size:
    471 amino acids
    Molecular mass:
    52785 Da
    Quaternary structure:
    No Data Available
  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YIM3
    Recommended name:
    Protein CHURC1-FNTB
    Protein Accession:
    H0YIM3
    Secondary Accessions:

    Protein attributes for CHURC1-FNTB Gene

    Size:
    107 amino acids
    Molecular mass:
    12015 Da
    Quaternary structure:
    No Data Available
  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YIM9
    Recommended name:
    Protein CHURC1-FNTB
    Protein Accession:
    H0YIM9
    Secondary Accessions:

    Protein attributes for CHURC1-FNTB Gene

    Size:
    85 amino acids
    Molecular mass:
    9824 Da
    Quaternary structure:
    No Data Available
  • Protein details for CHURC1-FNTB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YJ25
    Recommended name:
    Protein CHURC1-FNTB
    Protein Accession:
    H0YJ25
    Secondary Accessions:

    Protein attributes for CHURC1-FNTB Gene

    Size:
    69 amino acids
    Molecular mass:
    8074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHURC1-FNTB Gene

Proteomics data for CHURC1-FNTB Gene at MOPED

Post-translational modifications for CHURC1-FNTB Gene

No Post-translational modifications

Other Protein References for CHURC1-FNTB Gene

No data available for DME Specific Peptides for CHURC1-FNTB Gene

Domains for CHURC1-FNTB Gene

Protein Domains for CHURC1-FNTB Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHURC1-FNTB: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CHURC1-FNTB Gene

Function for CHURC1-FNTB Gene

Gene Ontology (GO) - Molecular Function for CHURC1-FNTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0008270 zinc ion binding --
genes like me logo Genes that share ontologies with CHURC1-FNTB: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHURC1-FNTB Gene

Localization for CHURC1-FNTB Gene

Gene Ontology (GO) - Cellular Components for CHURC1-FNTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005965 protein farnesyltransferase complex --
genes like me logo Genes that share ontologies with CHURC1-FNTB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CHURC1-FNTB Gene

Pathways for CHURC1-FNTB Gene

SuperPathways for CHURC1-FNTB Gene

No Data Available

Interacting Proteins for CHURC1-FNTB Gene

Gene Ontology (GO) - Biological Process for CHURC1-FNTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development --
GO:0018343 protein farnesylation --
GO:0042127 regulation of cell proliferation --
GO:0045893 positive regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with CHURC1-FNTB: view

No data available for Pathways by source for CHURC1-FNTB Gene

Transcripts for CHURC1-FNTB Gene

mRNA/cDNA for CHURC1-FNTB Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CHURC1-FNTB Gene

No ASD Table

Relevant External Links for CHURC1-FNTB Gene

GeneLoc Exon Structure for
CHURC1-FNTB
ECgene alternative splicing isoforms for
CHURC1-FNTB

Expression for CHURC1-FNTB Gene

mRNA expression in normal human tissues for CHURC1-FNTB Gene

Integrated Proteomics: protein expression from MaxQB for CHURC1-FNTB Gene

genes like me logo Genes that share expressions with CHURC1-FNTB: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHURC1-FNTB Gene

Orthologs for CHURC1-FNTB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHURC1-FNTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNTB 35
  • 99.93 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia FNTB 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fntb 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17565 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fntb-1 36
  • 43 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR275W 35
  • 48.98 (n)
  • 41.16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAM1 35
  • 46.35 (n)
  • 42.7 (a)
RAM1 36
  • 35 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07161g 35
  • 45.4 (n)
  • 40.33 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05999 35
  • 50.38 (n)
  • 45.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cpp1 35
  • 44.73 (n)
  • 42.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for CHURC1-FNTB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CHURC1-FNTB Gene

ENSEMBL:
Gene Tree for CHURC1-FNTB (if available)
TreeFam:
Gene Tree for CHURC1-FNTB (if available)

Paralogs for CHURC1-FNTB Gene

Paralogs for CHURC1-FNTB Gene

Selected SIMAP similar genes for CHURC1-FNTB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHURC1-FNTB: view

Variants for CHURC1-FNTB Gene

Sequence variations from dbSNP and Humsavar for CHURC1-FNTB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1951991 -- 64,936,047(-) TCAGA(G/T)TTTTC intron-variant
rs1951992 -- 64,935,960(-) CATGA(G/T)GGTTT intron-variant
rs2412066 -- 64,936,396(-) tatga(C/T)tgcac intron-variant
rs2412104 -- 64,980,746(-) TATAT(C/T)GAAAT intron-variant
rs2737851 -- 64,937,352(-) TTAGA(A/G)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHURC1-FNTB Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
esv33119 CNV Gain 17666407
esv21993 CNV Gain 19812545
nsv832816 CNV Gain 17160897
esv2506970 CNV Deletion 19546169
esv2748787 CNV Deletion 23290073
esv2665422 CNV Deletion 23128226

Relevant External Links for CHURC1-FNTB Gene

HapMap Linkage Disequilibrium report
CHURC1-FNTB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHURC1-FNTB Gene

Disorders for CHURC1-FNTB Gene

No disorders were found for CHURC1-FNTB Gene.

No data available for UniProtKB/Swiss-Prot for CHURC1-FNTB Gene

Publications for CHURC1-FNTB Gene

  1. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh S.K. … Lin J.P. (Nat. Genet. 2009) 3
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for CHURC1-FNTB Gene

Sources for CHURC1-FNTB Gene

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