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CHURC1-FNTB Gene

protein-coding   GIFtS: 23
GCID: GC14P065385

CHURC1-FNTB Readthrough

  Search for CHURC1-FNTB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CHURC1-FNTB Readthrough1 2
CHURC1-FNTB Protein2

External Ids:    HGNC: 429601   Entrez Gene: 1005292612   Ensembl: ENSG000001259547   UniProtKB: H0YHI04   UniProtKB: H0YIM34   
UniProtKB: H0YIM94   UniProtKB: H0YJ254   

Export aliases for CHURC1-FNTB gene to outside databases

Previous GC identifers: GC14U901261 GC14P065384


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHURC1-FNTB Gene:
This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill
domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript
produces a fusion protein that shares sequence identity with each individual gene product. (provided by RefSeq,
Feb 2011)

GeneCards Summary for CHURC1-FNTB Gene:
CHURC1-FNTB (CHURC1-FNTB readthrough) is a protein-coding gene. An important paralog of this gene is FNTB.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CHURC1-FNTB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CHURC1-FNTB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHURC1-FNTB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23.3

CHURC1-FNTB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHURC1-FNTB gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P065385:  view genomic region     (about GC identifiers)

Start:
65,381,079 bp from pter      End:
65,529,373 bp from pter
Size:
148,295 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/TrEMBL: H0YHI0 (See protein sequence)
Recommended Name: Protein CHURC1-FNTB  
Size: 472 amino acids; 52856 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H0YIM3 (See protein sequence)

Recommended Name: Protein CHURC1-FNTB  
Size: 107 amino acids; 12015 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H0YIM9 (See protein sequence)

Recommended Name: Protein CHURC1-FNTB  
Size: 85 amino acids; 9824 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H0YJ25 (See protein sequence)

Recommended Name: Protein CHURC1-FNTB  
Size: 69 amino acids; 8074 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

Explore proteomics data for CHURC1-FNTB at MOPED


See CHURC1-FNTB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001189487.1  NP_001189488.1  

ENSEMBL proteins: 
 ENSP00000449668   ENSP00000447121   ENSP00000450692   ENSP00000449709  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR026872 FTB
 IPR009508 Transcrpt_activator_Churchill
 IPR008930 Terpenoid_cyclase/PrenylTrfase
 IPR001330 Prenyltrans

Graphical View of Domain Structure for InterPro Entry H0YHI0
Graphical View of Domain Structure for InterPro Entry H0YIM3
Graphical View of Domain Structure for InterPro Entry H0YIM9
Graphical View of Domain Structure for InterPro Entry H0YJ25

ProtoNet protein and cluster: H0YHI0


CHURC1-FNTB for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004311farnesyltranstransferase activity ----
GO:0004660protein farnesyltransferase activity ----
GO:0008270zinc ion binding ----
GO:0016740transferase activity ----
     
CHURC1-FNTB for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005965protein farnesyltransferase complex ----

CHURC1-FNTB for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHURC1-FNTB
Interactions:

    Search GeneGlobe Interaction Network for CHURC1-FNTB

Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007275multicellular organismal development ----
GO:0008285negative regulation of cell proliferation ----
GO:0010035response to inorganic substance ----
GO:0014070response to organic cyclic compound ----
GO:0018343protein farnesylation ----

CHURC1-FNTB for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CHURC1-FNTB



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CHURC1-FNTB gene (2 alternative transcripts): 
NM_001202558.1  NM_001202559.1  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000552941 ENST00000549987 ENST00000553743 ENST00000551823
miRNA
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hsa-miR-142-3p hsa-miR-429 hsa-miR-3651 hsa-miR-374c hsa-miR-1244 hsa-miR-330-3p hsa-miR-376c hsa-miR-1827
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CHURC1-FNTB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CHURC1-FNTB Expression
About this image

CHURC1-FNTB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CHURC1-FNTB Protein Expression
    Custom PCR Arrays for CHURC1-FNTB
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHURC1-FNTB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for CHURC1-FNTB gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
Uncharacterized protein
81(a)
1 → many
1(267897884-267979925)
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
84(a)
1 → many
AADN03024998.1(1844-3671)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
78(a)
1 → many
1(93645197-93676840)
zebrafish
(Danio rerio)
Actinopterygii fntb6
farnesyltransferase, CAAX box, beta
68(a)
1 → many
20(28829885-28853668) ENSDARG00000027916
fruit fly
(Drosophila melanogaster)
Insecta CG175656
--
47(a)
1 → many
3R(12258703-12260462)
worm
(Caenorhabditis elegans)
Secernentea fntb-16
Protein FNTB-1 (fntb-1) mRNA, complete cds
43(a)
1 → many
V(14447651-14449591) WBGene00006465
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAM11 RAM1 46.35(n)
42.7(a)
  851468   NP_010193.1 


ENSEMBL Gene Tree for CHURC1-FNTB (if available)
TreeFam Gene Tree for CHURC1-FNTB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CHURC1-FNTB gene
FNTB2  
2 SIMAP similar genes for CHURC1-FNTB using alignment to 4 protein entries:     H0YHI0_HUMAN (see all proteins):
FNTB    CHURC1

CHURC1-FNTB for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CHURC1-FNTB (see all 243)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1852891061,2
--65402603(+) GTCACC/TTGCTA 2 -- int10--------
rs1896552601,2
--65402921(+) TAACAA/GTTTTT 2 -- int10--------
rs783944151,2
--65402960(+) CTAGTA/GTATAT 2 -- int10--------
rs1828806801,2
--65403055(+) GTTCTA/GGAGTT 2 -- int10--------
rs24120661,2
C,F--65403114(-) tatgaT/Ctgcac 2 -- int12Minor allele frequency- C:0.04WA 120
rs1507582191,2
C--65403139(+) CGAACC/TCCCAG 2 -- int10--------
rs1390285631,2
--65403145(+) CCCAGA/GCGCAA 2 -- int10--------
rs1439541551,2
--65403147(+) CAGGCA/GCAAGC 2 -- int10--------
rs1464291501,2
--65403282(+) CTACAC/TAGTGA 2 -- int10--------
rs1114806431,2
F--65403360(+) CATACG/TGGGCC 2 -- int11Minor allele frequency- T:0.50CSA 2

HapMap Linkage Disequilibrium report for CHURC1-FNTB (65381079 - 65529373 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for CHURC1-FNTB:    About this table    
Variant IDTypeSubtypePubMed ID
esv2748787CNV Deletion23290073
esv2506970CNV Deletion19546169
esv2748779CNV Deletion23290073
esv2665422CNV Deletion23128226
esv21993CNV Gain19812545
esv33119CNV Gain17666407
nsv832816CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CHURC1-FNTB gene integrated from 10 sources:
(articles sorted by number of sources associating them with CHURC1-FNTB)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)
  2. Seventy-five genetic loci influencing the human red blood cell. (PubMed id 23222517)1 van der Harst P....Chambers J.C. (Nature 2012)
  3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
  6. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  7. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1 Ganesh S.K....Lin J.P. (Nat. Genet. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100529261 HGNC: 42960 Ensembl:ENSG00000125954 euGenes: HUgn100529261 ECgene: CHURC1-FNTB
H-InvDB: CHURC1-FNTB

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CHURC1-FNTB gene:
Search GeneIP for patents involving CHURC1-FNTB

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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