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CHURC1 Gene(Protein Coding)

Churchill Domain Containing 1

GCID:
GC14P064915
GIFtS:
44
Genes Participants
UDN Logo

Aliases for CHURC1 Gene

Aliases for CHURC1 Gene

  • Churchill Domain Containing 1 2 3 5
  • C14orf52 3 4
  • Chch 3 4
  • Protein Churchill 3
  • My015 3

External Ids for CHURC1 Gene

Previous HGNC Symbols for CHURC1 Gene

  • C14orf52

Previous GeneCards Identifiers for CHURC1 Gene

  • GC14P063372
  • GC14P064450
  • GC14P065382
  • GC14P065383

Summaries for CHURC1 Gene

GeneCards Summary for CHURC1 Gene

CHURC1 (Churchill Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CHURC1 Gene

  • Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHURC1 Gene

Genomics for CHURC1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CHURC1 Gene

Enhancers for CHURC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G064937 1.3 Ensembl ENCODE 131.8 +26.6 26646 6.0 HNRNPUL1 FOXA2 MLX ARID4B DMAP1 YY1 TCF12 ZNF121 PAF1 SP5 CHURC1 CHURC1-FNTB RPPH1-2P RAB15 SPTB GPX2 GC14M064940
GH14G064926 0.9 Ensembl ENCODE 120.9 +14.3 14250 4.5 MTA2 MAFG FEZF1 ZIC2 ZBTB7B ZNF707 CBX5 ZNF585B IKZF1 NFE2 CHURC1 SPTB GC14P064933 CHURC1-FNTB
GH14G064919 0.6 Ensembl 120.8 +5.2 5241 0.4 SOX13 ZNF316 TEAD1 CEBPA CEBPB CEBPG EMSY MAFK TEAD3 CHURC1 GPX2 CHURC1-FNTB GC14P064933
GH14G064932 0.6 ENCODE 93.6 +18.0 18047 0.7 SOX5 SOX13 GATAD2A TEAD1 NCOR1 RCOR2 HNF4A ZBTB33 CHURC1 GC14P064933 CHURC1-FNTB
GH14G064891 0.7 ENCODE 63.1 -22.4 -22364 0.2 ZNF263 CTCF ZNF654 TRIM22 CEBPB REST RAD21 GABPA GATA3 GATA2 CHURC1 SPTB LOC105370534
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHURC1 on UCSC Golden Path with GeneCards custom track

Promoters for CHURC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069690 240 1600 PKNOX1 FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207

Transcription factor binding sites by QIAGEN in the CHURC1 gene promoter:

Genomic Location for CHURC1 Gene

Chromosome:
14
Start:
64,914,361 bp from pter
End:
64,944,591 bp from pter
Size:
30,231 bases
Orientation:
Plus strand

Genomic View for CHURC1 Gene

Genes around CHURC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHURC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHURC1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CHURC1 Gene

Proteins for CHURC1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CHURC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUH1-CHUR_HUMAN
    Recommended name:
    Protein Churchill
    Protein Accession:
    Q8WUH1
    Secondary Accessions:
    • B3KQ81
    • G3V1X3
    • G3V214
    • Q9H3K7

    Protein attributes for CHURC1 Gene

    Size:
    139 amino acids
    Molecular mass:
    16111 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG43128.1; Type=Miscellaneous discrepancy; Note=Frameshift at positions=92 and translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH20550.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG51943.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHURC1 Gene

    Alternative splice isoforms for CHURC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHURC1 Gene

Protein Expression for CHURC1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CHURC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHURC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHURC1 Gene

Domains & Families for CHURC1 Gene

Protein Domains for CHURC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CHURC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUH1

UniProtKB/Swiss-Prot:

CHUR_HUMAN :
  • Belongs to the Churchill family.
Family:
  • Belongs to the Churchill family.
genes like me logo Genes that share domains with CHURC1: view

No data available for Gene Families for CHURC1 Gene

Function for CHURC1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CHURC1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.

Gene Ontology (GO) - Molecular Function for CHURC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CHURC1: view

Phenotypes for CHURC1 Gene

GenomeRNAi human phenotypes for CHURC1:
genes like me logo Genes that share phenotypes with CHURC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHURC1 Gene

Localization for CHURC1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CHURC1 Gene

Pathways & Interactions for CHURC1 Gene

SuperPathways for CHURC1 Gene

PathCards logo More details on SuperPathways for CHURC1
No Data Available

Interacting Proteins for CHURC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000450144%0d%0a9606.ENSP00000367220%0d%0a
Selected Interacting proteins: ENSP00000450144 Q8WUH1-CHUR_HUMAN for CHURC1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CHURC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CHURC1: view

No data available for Pathways by source and SIGNOR curated interactions for CHURC1 Gene

Drugs & Compounds for CHURC1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CHURC1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CHURC1 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(304) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHURC1 Gene

Churchill domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHURC1 Gene

No ASD Table

Relevant External Links for CHURC1 Gene

GeneLoc Exon Structure for
CHURC1
ECgene alternative splicing isoforms for
CHURC1

Expression for CHURC1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHURC1 Gene

mRNA expression in normal human tissues for CHURC1 Gene
mRNA expression by BioGPS for CHURC1 GenemRNA expression by GTEx for CHURC1 Gene

Protein differential expression in normal tissues from HIPED for CHURC1 Gene

This gene is overexpressed in Cervix (33.8) and Peripheral blood mononuclear cells (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHURC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CHURC1 Gene:

CHURC1

SOURCE GeneReport for Unigene cluster for CHURC1 Gene:

Hs.731537

Evidence on tissue expression from TISSUES for CHURC1 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with CHURC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHURC1 Gene

Orthologs for CHURC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHURC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CHURC1 35
  • 100 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia CHURC1 34 35
  • 93.15 (n)
rat
(Rattus norvegicus)
 Mammalia Churc1 34
  • 92.26 (n)
mouse
(Mus musculus)
 Mammalia Churc1 34 16 35
  • 90.48 (n)
dog
(Canis familiaris)
 Mammalia CHURC1 34 35
  • 89.69 (n)
oppossum
(Monodelphis domestica)
 Mammalia CHURC1 35
  • 84 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CHURC1 35
  • 67 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CHURC1 34 35
  • 65.18 (n)
lizard
(Anolis carolinensis)
 Reptilia CHURC1 35
  • 71 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia churc1 34
  • 69.64 (n)
African clawed frog
(Xenopus laevis)
 Amphibia chch-A-prov 34
zebrafish
(Danio rerio)
 Actinopterygii churc1 34 35
  • 69.05 (n)
Species where no ortholog for CHURC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHURC1 Gene

ENSEMBL:
Gene Tree for CHURC1 (if available)
TreeFam:
Gene Tree for CHURC1 (if available)

Paralogs for CHURC1 Gene

(2) SIMAP similar genes for CHURC1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHURC1: view

No data available for Paralogs for CHURC1 Gene

Variants for CHURC1 Gene

Sequence variations from dbSNP and Humsavar for CHURC1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000405287 -- 64,914,216(+) TCAGC(C/T)CAAGA upstream-variant-2KB
rs1000469258 -- 64,922,533(+) AGAGT(A/G)TGCCA intron-variant
rs1000488309 -- 64,925,833(+) GTTAT(G/T)TGGCA intron-variant
rs1000641784 -- 64,931,629(+) AAACA(A/G)ACTTC intron-variant
rs1000837619 -- 64,926,142(+) GTGCT(C/G)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHURC1 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV deletion 23290073

Variation tolerance for CHURC1 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHURC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHURC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHURC1 Gene

Disorders for CHURC1 Gene

Relevant External Links for CHURC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHURC1

No disorders were found for CHURC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHURC1 Gene

Publications for CHURC1 Gene

  1. Embryonic neural inducing factor Churchill is not a DNA-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster. (PMID: 17610897) Lee B.M. … Wright P.E. (J. Mol. Biol. 2007) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A de novo 1.5a88Mb microdeletion on chromosome 14q23.2-23.3 in a patient with autism and spherocytosis. (PMID: 21360829) Griswold A.J. … Pericak-Vance M.A. (Autism Res 2011) 3 64

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