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Aliases for CHURC1 Gene

Aliases for CHURC1 Gene

  • Churchill Domain Containing 1 2 3 5
  • C14orf52 3 4
  • Chch 3 4
  • Protein Churchill 3
  • My015 3

External Ids for CHURC1 Gene

Previous HGNC Symbols for CHURC1 Gene

  • C14orf52

Previous GeneCards Identifiers for CHURC1 Gene

  • GC14P063372
  • GC14P064450
  • GC14P065382
  • GC14P065383

Summaries for CHURC1 Gene

GeneCards Summary for CHURC1 Gene

CHURC1 (Churchill Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CHURC1 Gene

  • Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.

Additional gene information for CHURC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHURC1 Gene

Genomics for CHURC1 Gene

Regulatory Elements for CHURC1 Gene

Enhancers for CHURC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H064937 1.3 Ensembl ENCODE 131.8 +26.6 26646 6 FOXA2 MLX ARID4B DMAP1 YY1 TCF12 PAF1 SP5 MXD4 REST CHURC1 CHURC1-FNTB RPPH1-2P RAB15 SPTB GPX2 GC14M064940
GH14H064926 0.9 Ensembl ENCODE 120.9 +14.3 14250 4 ZNF687 MAFG FEZF1 ZIC2 IKZF1 NFE2 HNF4A IKZF2 RUNX3 CHURC1 SPTB GC14P064933 CHURC1-FNTB
GH14H064919 0.6 Ensembl 120.8 +5.2 5241 0 SOX13 ZNF316 TEAD1 CEBPA CEBPB CEBPG EMSY MAFK TEAD3 CHURC1 GPX2 CHURC1-FNTB GC14P064933
GH14H064932 0.6 ENCODE 93.6 +18.0 18047 0 SOX5 SOX13 GATAD2A TEAD1 RCOR2 HNF4A KDM1A CHURC1 GC14P064933 CHURC1-FNTB
GH14H064891 0.7 ENCODE 63 -22.4 -22364 0 CTCF RAD21 GATA3 GATA2 SMC3 ZNF143 CREM SMARCA5 ZNF654 CEBPB CHURC1 SPTB LOC105370534
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHURC1 on UCSC Golden Path with GeneCards custom track

Promoters for CHURC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069690 240 1600 PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 ELK1

Genomic Location for CHURC1 Gene

Chromosome:
14
Start:
64,914,361 bp from pter
End:
64,944,591 bp from pter
Size:
30,231 bases
Orientation:
Plus strand

Genomic View for CHURC1 Gene

Genes around CHURC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHURC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHURC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHURC1 Gene

Proteins for CHURC1 Gene

  • Protein details for CHURC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUH1-CHUR_HUMAN
    Recommended name:
    Protein Churchill
    Protein Accession:
    Q8WUH1
    Secondary Accessions:
    • B3KQ81
    • G3V1X3
    • G3V214
    • Q9H3K7

    Protein attributes for CHURC1 Gene

    Size:
    139 amino acids
    Molecular mass:
    16111 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG43128.1; Type=Miscellaneous discrepancy; Note=Frameshift at positions=92 and translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH20550.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG51943.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHURC1 Gene

    Alternative splice isoforms for CHURC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHURC1 Gene

Post-translational modifications for CHURC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CHURC1 Gene

Domains & Families for CHURC1 Gene

Gene Families for CHURC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CHURC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CHURC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUH1

UniProtKB/Swiss-Prot:

CHUR_HUMAN :
  • Belongs to the Churchill family.
Family:
  • Belongs to the Churchill family.
genes like me logo Genes that share domains with CHURC1: view

Function for CHURC1 Gene

Molecular function for CHURC1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.

Phenotypes From GWAS Catalog for CHURC1 Gene

Gene Ontology (GO) - Molecular Function for CHURC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CHURC1: view

Phenotypes for CHURC1 Gene

genes like me logo Genes that share phenotypes with CHURC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHURC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHURC1 Gene

Localization for CHURC1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CHURC1 Gene

Pathways & Interactions for CHURC1 Gene

SuperPathways for CHURC1 Gene

No Data Available

Interacting Proteins for CHURC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000450144%0d%0a9606.ENSP00000367220%0d%0a
Selected Interacting proteins: ENSP00000450144 Q8WUH1-CHUR_HUMAN for CHURC1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CHURC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CHURC1: view

No data available for Pathways by source and SIGNOR curated interactions for CHURC1 Gene

Drugs & Compounds for CHURC1 Gene

No Compound Related Data Available

Transcripts for CHURC1 Gene

Unigene Clusters for CHURC1 Gene

Churchill domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHURC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CHURC1 Gene

No ASD Table

Relevant External Links for CHURC1 Gene

GeneLoc Exon Structure for
CHURC1
ECgene alternative splicing isoforms for
CHURC1

Expression for CHURC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHURC1 Gene

Protein differential expression in normal tissues from HIPED for CHURC1 Gene

This gene is overexpressed in Cervix (33.8) and Peripheral blood mononuclear cells (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHURC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CHURC1 Gene:

CHURC1

SOURCE GeneReport for Unigene cluster for CHURC1 Gene:

Hs.731537

Evidence on tissue expression from TISSUES for CHURC1 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with CHURC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHURC1 Gene

Orthologs for CHURC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHURC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHURC1 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHURC1 33 34
  • 93.15 (n)
rat
(Rattus norvegicus)
Mammalia Churc1 33
  • 92.26 (n)
mouse
(Mus musculus)
Mammalia Churc1 33 16 34
  • 90.48 (n)
dog
(Canis familiaris)
Mammalia CHURC1 33 34
  • 89.69 (n)
oppossum
(Monodelphis domestica)
Mammalia CHURC1 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHURC1 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHURC1 33 34
  • 65.18 (n)
lizard
(Anolis carolinensis)
Reptilia CHURC1 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia churc1 33
  • 69.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia chch-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii churc1 33 34
  • 69.05 (n)
Species where no ortholog for CHURC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHURC1 Gene

ENSEMBL:
Gene Tree for CHURC1 (if available)
TreeFam:
Gene Tree for CHURC1 (if available)

Paralogs for CHURC1 Gene

(2) SIMAP similar genes for CHURC1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHURC1: view

No data available for Paralogs for CHURC1 Gene

Variants for CHURC1 Gene

Sequence variations from dbSNP and Humsavar for CHURC1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000405287 -- 64,914,216(+) TCAGC(C/T)CAAGA upstream-variant-2KB
rs1000469258 -- 64,922,533(+) AGAGT(A/G)TGCCA intron-variant
rs1000488309 -- 64,925,833(+) GTTAT(G/T)TGGCA intron-variant
rs1000641784 -- 64,931,629(+) AAACA(A/G)ACTTC intron-variant
rs1000837619 -- 64,926,142(+) GTGCT(C/G)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHURC1 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV deletion 23290073

Variation tolerance for CHURC1 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHURC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHURC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHURC1 Gene

Disorders for CHURC1 Gene

Relevant External Links for CHURC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHURC1

No disorders were found for CHURC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHURC1 Gene

Publications for CHURC1 Gene

  1. Embryonic neural inducing factor churchill is not a DNA-binding zinc finger protein: solution structure reveals a solvent-exposed beta-sheet and zinc binuclear cluster. (PMID: 17610897) Lee BM … Wright PE (Journal of molecular biology 2007) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for CHURC1 Gene

Sources for CHURC1 Gene

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