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Aliases for CHURC1 Gene

Aliases for CHURC1 Gene

  • Churchill Domain Containing 1 2 3
  • C14orf52 3 4
  • Chch 3 4
  • Protein Churchill 3
  • My015 3

External Ids for CHURC1 Gene

Previous Symbols for CHURC1 Gene

  • C14orf52

Summaries for CHURC1 Gene

GeneCards Summary for CHURC1 Gene

CHURC1 (Churchill Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CHURC1 Gene

  • Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHURC1 Gene

Genomics for CHURC1 Gene

Genomic Location for CHURC1 Gene

64,914,361 bp from pter
64,944,591 bp from pter
30,231 bases
Plus strand

Genomic View for CHURC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHURC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHURC1 Gene

Regulatory Elements for CHURC1 Gene

Proteins for CHURC1 Gene

  • Protein details for CHURC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Churchill
    Protein Accession:
    Secondary Accessions:
    • B3KQ81
    • G3V1X3
    • G3V214
    • Q9H3K7

    Protein attributes for CHURC1 Gene

    139 amino acids
    Molecular mass:
    16111 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG43128.1; Type=Miscellaneous discrepancy; Note=Frameshift at positions=92 and translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH20550.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG51943.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHURC1 Gene

    Alternative splice isoforms for CHURC1 Gene


neXtProt entry for CHURC1 Gene

Proteomics data for CHURC1 Gene at MOPED

Post-translational modifications for CHURC1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CHURC1 Gene

Domains for CHURC1 Gene

Protein Domains for CHURC1 Gene


Suggested Antigen Peptide Sequences for CHURC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Churchill family.:
    • Q8WUH1
genes like me logo Genes that share domains with CHURC1: view

No data available for Gene Families for CHURC1 Gene

Function for CHURC1 Gene

Molecular function for CHURC1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.

Gene Ontology (GO) - Molecular Function for CHURC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CHURC1: view

Phenotypes for CHURC1 Gene

GenomeRNAi human phenotypes for CHURC1:
genes like me logo Genes that share phenotypes with CHURC1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHURC1 Gene

Localization for CHURC1 Gene

Subcellular locations from

Jensen Localization Image for CHURC1 Gene COMPARTMENTS Subcellular localization image for CHURC1 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CHURC1 Gene

Pathways for CHURC1 Gene

SuperPathways for CHURC1 Gene

No Data Available

Interacting Proteins for CHURC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000450144 Q8WUH1-CHUR_HUMAN for CHURC1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CHURC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CHURC1: view

No data available for Pathways by source for CHURC1 Gene

Transcripts for CHURC1 Gene

Unigene Clusters for CHURC1 Gene

Churchill domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHURC1 Gene

No ASD Table

Relevant External Links for CHURC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHURC1 Gene

mRNA expression in normal human tissues for CHURC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CHURC1 Gene

SOURCE GeneReport for Unigene cluster for CHURC1 Gene Hs.731537

genes like me logo Genes that share expressions with CHURC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHURC1 Gene

Orthologs for CHURC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHURC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHURC1 36
  • 100 (a)
(Bos Taurus)
Mammalia CHURC1 35
  • 93.15 (n)
  • 95.54 (a)
  • 96 (a)
(Canis familiaris)
Mammalia CHURC1 35
  • 89.69 (n)
  • 91.37 (a)
  • 92 (a)
(Mus musculus)
Mammalia Churc1 35
  • 90.48 (n)
  • 95.54 (a)
Churc1 16
Churc1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia CHURC1 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia CHURC1 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Churc1 35
  • 92.26 (n)
  • 95.54 (a)
(Gallus gallus)
Aves CHURC1 35
  • 65.18 (n)
  • 70.54 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia CHURC1 36
  • 71 (a)
African clawed frog
(Xenopus laevis)
Amphibia chch-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia churc1 35
  • 69.64 (n)
  • 71.43 (a)
(Danio rerio)
Actinopterygii churc1 35
  • 69.05 (n)
  • 68.75 (a)
churc1 36
  • 69 (a)
Species with no ortholog for CHURC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHURC1 Gene

Gene Tree for CHURC1 (if available)
Gene Tree for CHURC1 (if available)

Paralogs for CHURC1 Gene

Selected SIMAP similar genes for CHURC1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHURC1: view

No data available for Paralogs for CHURC1 Gene

Variants for CHURC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CHURC1 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073

Relevant External Links for CHURC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CHURC1 Gene

Disorders for CHURC1 Gene

No disorders were found for CHURC1 Gene.

No data available for UniProtKB/Swiss-Prot for CHURC1 Gene

Publications for CHURC1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Embryonic neural inducing factor Churchill is not a DNA-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster. (PMID: 17610897) Lee B.M. … Wright P.E. (J. Mol. Biol. 2007) 3 4
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. A de novo 1.5a88Mb microdeletion on chromosome 14q23.2-23.3 in a patient with autism and spherocytosis. (PMID: 21360829) Griswold A.J. … Pericak-Vance M.A. (Autism Res 2011) 3

Products for CHURC1 Gene

Sources for CHURC1 Gene

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