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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHURC1 Gene

protein-coding   GIFtS: 40
GCID: GC14P065383

churchill domain containing 1


(Previous symbol: C14orf52)
 Explore 1 disease affiliated with
CHURC1 via our new
 Human Malady Compendium 
Biological research products
for CHURC1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Churchill Domain Containing 11 2     Chch1
C14orf521 2 3     Protein Churchill2
FLJ330641     CHCH3
My0151     

External Ids:    HGNC: 200991   Entrez Gene: 916122   Ensembl: ENSG000002582897   OMIM: 6085775   UniProtKB: Q8WUH13   

Export aliases for CHURC1 gene to outside databases

Previous GC identifers: GC14P063372 GC14P064450 GC14P065382


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CHUR_HUMAN, Q8WUH1
Function: Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the
regulation of cell movement (By similarity). Does not bind DNA by itself




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHURC1 gene promoter:
         TBP   ISGF-3   Nkx2-5   C/EBPalpha   HNF-1A   CHOP-10   FOXC1   HNF-1   TFIID   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHURC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHURC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHURC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23.3

CHURC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHURC1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P065383:  view genomic region     (about GC identifiers)

Start:
65,381,079 bp from pter      End:
65,411,309 bp from pter
Size:
30,231 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHUR_HUMAN, Q8WUH1 (See protein sequence)
Recommended Name: Protein Churchill  
Size: 112 amino acids; 12887 Da
Mass spectrometry: Mass=13033; Method=MALDI; Range=1-112; Note=The mass difference may be explained by bound zinc ions;
Source=PubMed:17610897;
Sequence caution: Sequence=AAG43128.1; Type=Frameshift; Positions=92;
1 PDB 3D structure from and Proteopedia for CHURC1:
2JOX (3D)    
Secondary accessions: B3KQ81 Q9H3K7
Alternative splicing: 2 isoforms:  Q8WUH1-1   Q8WUH1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHURC1: NX_Q8WUH1

CHURC1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (3 alternative transcripts): 
NP_001190992.1  NP_001190993.1  NP_660148.3  

ENSEMBL proteins: 
 ENSP00000450144   ENSP00000448050   ENSP00000450165   ENSP00000446697   ENSP00000446610  
 ENSP00000449184   ENSP00000352026  

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CHURC1 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR009508 Transcrpt_activator_Churchill

Graphical View of Domain Structure for InterPro Entry Q8WUH1

ProtoNet protein and cluster: Q8WUH1

1 Blocks protein family: IPB009508 Churchill

UniProtKB/Swiss-Prot: CHUR_HUMAN, Q8WUH1
Similarity: Belongs to the Churchill family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: CHUR_HUMAN, Q8WUH1
Function: Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the
regulation of cell movement (By similarity). Does not bind DNA by itself

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008270zinc ion binding IEA--


CHURC1 for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for CHURC1:
 Decreased viability with pacli 


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHURC1

2 Interacting proteins for CHURC1 (Q8WUH13) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SERTAD1Q9UHV23I2D: score=1 
ZBTB9Q96C003I2D: score=1 
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0007275multicellular organismal development IEA--
GO:0045893positive regulation of transcription, DNA-dependent IEA--


CHURC1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CHURC1
Search CenterWatch for drugs/clinical trials and news about CHURC1 / CHUR 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CHURC1 gene (3 alternative transcripts): 
NM_001204063.1  NM_001204064.1  NM_145165.3  

Unigene Cluster for CHURC1:

Churchill domain containing 1
Hs.731537  [show with all ESTs]
Unigene Representative Sequence: NM_145165
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000552002 ENST00000549115 ENST00000548752 ENST00000551947(uc010tsk.2 uc010tsj.2)
ENST00000556089 ENST00000551093 ENST00000547625 ENST00000359118(uc001xhv.2 uc001xhw.2 uc021rup.1)


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hsa-miR-548j hsa-miR-4291 hsa-miR-2052 hsa-miR-548k hsa-miR-548l hsa-miR-298 hsa-miR-548a-5p hsa-miR-548d-5p
SwitchGear 3'UTR luciferase reporter plasmidCHURC1 3' UTR sequence
Inhib. RNA
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Clone
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Additional cDNA sequence: 

AF060510.1 AK057626.1 AK296141.1 AK315905.1 BC010517.1 BC020550.1 

11 DOTS entries:

DT.445632  DT.447119  DT.120751802  DT.424574  DT.92431261  DT.95369769  DT.100683597  DT.101977195 
DT.120751749  DT.95369771  DT.99998521 

24/304 AceView cDNA sequences (see all 304):

CA941926 AI089948 AA830066 BU507027 AA316566 BM314958 BC010517 AK057626 
BF430939 BX111129 BP370748 BM908308 CA950480 AI741393 CB266415 AA962528 
AI306540 CA950253 AI244563 BQ957354 AA452621 BU738442 AI540098 BF476469 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CHURC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

CHURC1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See CHURC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHURC1

SOURCE GeneReport for Unigene cluster: Hs.731537
    SABiosciences Custom PCR Arrays for CHURC1
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHURC1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CHURC1 gene from 5/15 species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Churc11 , 5 churchill domain containing 11, 5 90.48(n)1
95.54(a)1
  12 (33.73 cM)5
2111511  NM_206534.11  NP_996257.11 
 767655385 
chicken
(Gallus gallus)
Aves CHURC11 churchill domain containing 1 65.18(n)
70.54(a)
  395448  NM_204709.1  NP_990040.1 
lizard
(Anolis carolinensis)
Reptilia CHURC16
--
72(a)
1 ↔ 1
1(93752461-93765719)
African clawed frog
(Xenopus laevis)
Amphibia chch-A-prov2 Churchill protein 76.59(n)    AF238862.1 
zebrafish
(Danio rerio)
Actinopterygii CD580853.12   -- 75.42(n)    CD580853.1 


ENSEMBL Gene Tree for CHURC1 (if available)
TreeFam Gene Tree for CHURC1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/409 NCBI SNPs in CHURC1 are shown (see all 409    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1807159001,2
--65379097(+) AAAGTC/GCTTTA 5 -- us2k10--------
rs71434321,2
C,F,A,H,--65379146(+) TTGAGA/CTAAGG 5 -- us2k118Minor allele frequency- C:0.28NS EA NA CSA WA 2340
rs71448111,2
C,F,A,H,--65379147(+) TGAGAT/CAAGGA 5 -- us2k118Minor allele frequency- C:0.28NS EA NA CSA WA 2334
rs1505022581,2
--65379204(+) CCATAA/GACAAG 5 -- us2k10--------
rs1383914591,2
--65379258(+) GAGACA/GTATTT 5 -- us2k10--------
rs1851567661,2
--65379262(+) CATATC/TTTTCT 5 -- us2k10--------
rs1892305791,2
--65379274(+) ACCAAA/CCACAT 5 -- us2k10--------
rs71437641,2
C,F,A,H,--65379283(+) ATAGGA/GTTGTA 5 -- us2k112Minor allele frequency- G:0.24NS EA NA WA CSA 742
rs1440801551,2
--65379312(+) CTGAAA/CTGAGG 5 -- us2k10--------
rs64208961,2
C,F,H,--65379404(+) AGTTCA/TTGCAG 5 -- us2k118Minor allele frequency- T:0.08NS EA NA WA CSA 1133

HapMap Linkage Disequilibrium report for CHURC1 (65381079 - 65411309 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CHURC1: --

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CHURC1 for disorders           About GeneDecksing

OMIM gene information: 608577    OMIM disorders: --

1 disease for CHURC1:    About MalaCards
spherocytosis


Export disorders for CHURC1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CHURC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CHURC1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Embryonic neural inducing factor Churchill is not a DNA-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster. (PubMed id 17610897)1, 2 Lee B.M....Wright P.E. (2007)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. A de novo 1.5a88Mb microdeletion on chromosome 14q23.2- 23.3 in a patient with autism and spherocytosis. (PubMed id 21360829)1 Griswold A.J....Pericak-Vance M.A. (2011)
  5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
  7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
  8. Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation. (PubMed id 14651851)1 Sheng G....Stern C.D. (2003)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 91612 HGNC: 20099 AceView: CHURC1 Ensembl:ENSG00000258289 euGenes: HUgn91612
ECgene: CHURC1 H-InvDB: CHURC1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CHURC1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CHURC1 gene:
Search GeneIP for patents involving CHURC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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