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CHUK Gene

protein-coding GIFtS: 65

GC10M101938

conserved helix-loop-helix ubiquitous kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TCF16)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.10 ^³
IKBKA ^², ⁵
IKK-A ^³
IKK-alpha ^¹, ², ³
IKK1 ^¹, ², ³, ⁵
IKKA ^¹, ², ³, ⁵
IkBKA ^¹, ³
NFKBIKA ^¹, ², ³, ⁵
OTTHUMP00000020273 ^²
TCF16 ^², ³

Descriptions
I kappa-B kinase alpha ^³
I-kappa-B kinase 1 ^², ³
I-kappa-B kinase-alpha ^²
IKK-a kinase ^²
IkB kinase alpha subunit ^²
IkappaB kinase ^³
Nuclear factor NF-kappa-B inhibitor kinase alpha ^³
Nuclear factor NFkappaB inhibitor kinase alpha ^²
conserved helix-loop ubiquitous kinase ^²
conserved helix-loop-helix ubiquitous kinase ^², ³

External Ids
HGNC: 1974¹
Entrez Gene: 1147²
UniProtKB: O15111³
Ensembl: ENSG00000213341⁷

Search outside databases for aliases for CHUK gene

Previous GC identifers: GC10M100841 GC10M101181 GC10M102079 GC10M101612

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CHUK:

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a

component of a cytokine-activated protein complex that is an inhibitor of the essential

transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the

inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by

RefSeq]

UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111

Function: Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and

phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the

inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the

non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer

phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52

and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates

'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered

by cytokines

Gene Wiki entry for CHUK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CHUK gene

Entrez Gene cytogenetic band: 10q24-q25 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24-q25

CHUK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M101938: (about GC identifiers)

Start:	101,938,114 bp from pter
End:	101,979,334 bp from pter
Size:	41,221 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111 (See protein sequence)

Recommended Name: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Size: 745 amino acids; 84654 Da

Subunit: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG;

probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK

core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome

holo-complex. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part

of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14.

Directly interacts with IKK-gamma/NEMO and TRPC4AP (By similarity). May interact with TRAF2.

Interacts with NALP2. May interact with MAVS/IPS1

Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus

PDB structures from and Proteopedia :

3BRT (3D)

Secondary accessions: O14666 Q13132 Q5W0I4 Q92467

Post-translational modifications:

Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A.

Autophosphorylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001269.3

ENSEMBL proteins:

ENSP00000359424

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CHUK
	Millipore Purified and/or Recombinant CHUK Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IKK alpha, IKK alpha + IKK beta)
	Human Recombinant Proteins from Abnova (CHUK)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	9252186
GO:0005829	cytosol	EXP	9744859 10485710 10723127

About this table

Antibodies for CHUK:

	Invitrogen Antibodies for CHUK
	Millipore Mono- and Polyclonal Antibodies for the study of CHUK
	Sigma-Aldrich Antibody Arrays and Antibodies for CHUK
	R&D Systems Antibodies for CHUK (IKK alpha)
	Cell Signaling Technology (CST) Antibodies for CHUK (IKKa)
	Antibodies from Abcam (IKK alpha, IKK alpha + IKK beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CHUK)
	Novus Biologicals Antibodies for CHUK

Assays for CHUK:

	Invitrogen Assays for CHUK
	Millipore Kits and Assays for the Analysis of CHUK
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15111

ProtoNet protein and cluster: O15111

UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B

kinase subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHUK)
		Millipore RNAi Products for the Analysis of CHUK Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CHUK)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001278

Applied Biosystems Silencer® siRNAs for CHUK

Sigma-Aldrich siRNA and siRNA Panels for CHUK

Sigma-Aldrich shRNA Panels and shRNA for CHUK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001278
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001278
untagged cDNA clones in CMV expression vector (see all 2): NM_001278

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001278

UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111

Function: Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and

phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the

inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the

non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer

phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52

and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates

'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered

by cytokines

Catalytic activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]

Enzyme regulation: Activated when phosphorylated and inactivated when dephosphorylated

Enzyme Number (IUBMB): EC 2.7.11.10

Genatlas biochemistry entry for CHUK:

I kappa B alpha-kinase inhibitor of kappa light polypeptide enhancer in B cells (NFKB),kinase

alpha,activated by MEKK1,complexing with IKBKB

15/24 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Chuk) (see all 24 ):

cellular	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	liver/biliary system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008384	IkappaB kinase activity	TAS	9252186
GO:0016740	transferase activity	IEA	--
GO:0042802	identical protein binding	IPI	9520446

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/39 Sigma-Aldrich "Your Favorite Gene" Pathways for CHUK (Your Favorite Gene powered by Ingenuity) (see all 39 )

Chronic Myeloid Leukemia Signaling
IL-12 Signaling and Production in Macrophages
G-Protein Coupled Receptor Signaling
Type I Diabetes Mellitus Signaling
Acute Phase Response Signaling

GeneDecks CHUK for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CHUK

5/161 Interacting proteins for CHUK (ENSP00000359424³ O15111^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 161 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAVS	Q7Z434¹	STRING (score=.808) EBI-81249, EBI-995373
NFKB1	P19838²	STRING (score=.999) MINT-47906 MINT-47887 MINT-48533 MINT-48643
NFKB2	Q00653²	STRING (score=.998) MINT-47921 MINT-47898 MINT-48569 MINT-48699
CDC37	Q16543²	STRING (score=.915) MINT-47951
MAP3K3	Q99759²	STRING (score=.939) MINT-48382

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002011	morphogenesis of an epithelial sheet	IEA	--
GO:0006955	immune response	TAS	9346484
GO:0007252	I-kappaB phosphorylation	TAS	9252186
GO:0009653	anatomical structure morphogenesis	TAS	10747982
GO:0030316	osteoclast differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for CHUK available from Tocris Bioscience

Compound	Action	CAS number
IKK 16	Selective inhibitor of IKK

About this table

10/38 Novoseek chemical compound relationships for CHUK gene (see all 38 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tab-2	79.01	1	15836773 (1)
tab-1	74.80	3	10187861 (2), 17633026 (1)
acetyl-11-keto-beta-boswellic acid	67.06	1	18032778 (1)
ppme	57.62	1	9915837 (1)
guggulsterone	50.28	1	17119390 (1)
phosphatidylinositol	47.13	8	14585846 (3), 12584727 (1), 18657320 (1), 17172471 (1) (see all 5)
sp 600125	42.73	2	14647474 (1), 16455066 (1)
pd 98,059	35.03	1	15821443 (1)
threonine	32.96	7	9742107 (1), 9804849 (1), 16126728 (1), 9813230 (1) (see all 7)
poly(i-c)	28.67	1	16265667 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHUK)
		Millipore RNAi Products for the Analysis of CHUK Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CHUK)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001278

Sigma-Aldrich siRNA and siRNA Panels for CHUK

Sigma-Aldrich shRNA Panels and shRNA for CHUK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001278

REFSEQ mRNAs for CHUK gene:

NM_001278.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001278

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001278
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001278
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001278

Additional cDNA sequence:

AB209028.1 AF009225.1 AF012890.1 AF080157.1 AY952888.2 BC034796.1 BC092514.1 U22512.1

8 DOTS entries:

DT.100814684 DT.454093 DT.101978418 DT.100675447 DT.98083593 DT.92037566 DT.95162259 DT.100814686

24/357 AceView cDNA sequences (see all 357 ):

BU729203 BX644191 AI192268 BC034796 CR626509 BM695959 AW780178 AF012890

AU280728 BX383252 BM552188 BU192550 AA280792 BQ101058 NM_006459 AI700295

CN482133 AI968640 BG696728 AA574067 AI276320 CB988839 AF064093 AI458619

highest scoring ESTs for CHUK:

AF009225 AF012890 AF080157 AW502600 AW504887 BU428626 CN482133 U22512 CN356185 CN356186

Unigene Cluster for CHUK:

Conserved helix-loop-helix ubiquitous kinase

Hs.198998 [show with all ESTs]

Unigene Representative Sequence: AB209028

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000370397

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CHUK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CHUK

¹ / ² / ³

3 probe-sets matching CHUK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33770_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF009225	1.00	0.90	0.95	1
209666_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF080157	0.80	0.88	0.84	1
209666_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAACCATTCT

SOURCE GeneReport for Unigene cluster: Hs.198998
UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111
Tissue specificity: Widely expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CHUK gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CHUK¹	--	conserved helix-loop-helix ubiquitous kinase	94.63(n) 97.58(a)	477796 XM_856431.1 XP_861524.1
chimpanzee (Pan troglodytes)	CHUK¹	--	conserved helix-loop-helix ubiquitous kinase	99.15(n) 98.93(a)	450673 XM_001167677.1 XP_001167677.1
cow (Bos taurus)	CHUK¹	--	conserved helix-loop-helix ubiquitous kinase	94.68(n) 97.7(a)	281073 NM_174021.2 NP_776446.1
rat (Rattus norvegicus)	Chuk¹	--	conserved helix-loop-helix ubiquitous kinase	92.57(n) 95.17(a)	309361 XM_219857.4 XP_219857.3
mouse (Mus musculus)	Chuk^{1, 5}	19 (45.00 cM)⁵	conserved helix-loop-helix ubiquitous kinase^{1, 5}	92.44(n)¹ 95.44(a)¹	12675¹ NM_007700.1¹ NP_031726.1¹ AI256658⁵ AI528668⁵ (see all 19)

About this table Species with no ortholog for CHUK

ENSEMBL Gene Tree for CHUK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CHUK gene

IKBKB² IKBKE² TBK1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/338 NCBI SNPs in CHUK are shown (see all 338 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 147)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs3763711^1,2	A,C,F	101979865(+)	`cacctT/Cggcat`	1	--	ng3¹		1	NS	48
	rs3808917^1,2	C,F,H	101980705(+)	`TGAAGC/ACCTCT`	1	--	ng3¹		8	EU EA WA	836
	rs2230804^1,2	C,F,H	101967873(-)	`GTTTAA/GTAGTA`	1	V/I	mis¹		17	MN EA NA NS EU WA	2564
	rs12770784^1,2	C,F	101979500(+)	`CCCTAC/TGTATT`	1	--	ng3¹		10	NS EA	932
	rs17886588^1,2	C,F	101980409(-)	`CTTAAA/GTGGAA`	1	--	ng3¹		7	NS	712
	rs17883880^1,2	C,F	101980337(-)	`ACAGCA/TTTCCC`	1	--	ng3¹		7	NS	692
--	rs7099951^1,2	C,F	101981115(+)	`gctaaT/Attttt`	1	--	ng3¹		1	NS	42
	rs3829158^1,2	C,F	101979439(+)	`CCAGAG/TCCCTG`	1	--	ng3¹		1	NS	46
	rs34427437^1,2	C,F	101971868(+)	`ATCACT/ATAGTA`	1	C/S	mis¹		4	EU EA WA	420
	rs17883397^1,2	C	101979583(-)	`TTTGAC/GGGGAA`	1	--	ng3¹		1	NS	46

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HapMap Linkage Disequilibrium images for CHUK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600664

10/41 Novoseek disease relationships for CHUK gene (see all 41 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	73.23	63	11054378 (2), 17897950 (2), 9710600 (1), 10542212 (1) (see all 53)
leukemia t-cell	65.01	10	9710600 (1), 11064457 (1), 11726516 (1), 16611882 (1) (see all 9)
tumors	63.11	99	19074890 (4), 11054378 (2), 11752211 (2), 17644309 (2) (see all 68)
inflammation	56.53	17	17371257 (2), 16009742 (1), 9520464 (1), 18163512 (1) (see all 15)
ectodermal dysplasia, hypohidrotic	54.37	2	14734108 (1), 14523047 (1)
cancer	39.03	15	19116119 (2), 18831712 (1), 17277159 (1), 11520600 (1) (see all 11)
ataxia telangiectasia	32.68	2	17700524 (1), 16497931 (1)
ectodermal dysplasia	25.97	6	18633439 (4)
lymphoma b-cell	24.42	1	15671525 (1)
shock	18.20	4	15922746 (2), 15302572 (1), 18347582 (1)

About this table

Human Genome Epidemiology Navigator: CHUK (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Researchers Identify Key Inflammatory Response Mediator

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

11/607 PubMed articles for CHUK gene (see all 607 ):

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. (PubMed id 9520446)^{1, 3, 4} Ling L.... Goeddel D.V. (1998)
IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. (PubMed id 9813230)^{1, 3, 4} Hu M.C.-T. and Wang Y.-P. (1998)
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF- kappaB activation. (PubMed id 9346484)^{1, 3, 4} Mercurio F.... Rao A. (1997)
IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression. (PubMed id 16902410)^{1, 2, 3} Schneider G....Schmid R.M. (2006)
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. (PubMed id 9819420)^{1, 3, 4} Nemoto S.... Lin A. (1998)
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. (PubMed id 10195894)^{1, 3, 4} Delhase M.... Karin M. (1999)
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. (PubMed id 10485710)^{1, 3, 4} Ozes O.N....Donner D.B. (1999)
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. (PubMed id 16177806)^{3, 4} Meylan E.... Tschopp J. (2005)
PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. (PubMed id 15456791)^{3, 4} Bruey J.-M....Reed J.C. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
IkBalpha Promoter Polymorphisms in Patients with Primary Sjogren's Syndrome. (PubMed id 18600435)³ Ou T.T....Yen J.H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Search String
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1147	HGNC: 1974	AceView: CHUK	Ensembl:ENSG00000213341	euGenes: HUgn1147
ECgene: CHUK	H-InvDB: CHUK

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CHUK	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/chuk/

Licensable Technologies for CHUK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CHUK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CHUK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CHUK		Antibodies for CHUK
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CHUK		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CHUK)
	Antibodies (CHUK)
	Chimera RNAi (CHUK)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CHUK (IKKa)

	Recombinant Proteins (IKK alpha, IKK alpha + IKK beta)
	Antibodies (IKK alpha, IKK alpha + IKK beta)

Search OriGene for CHUK

Tocris compounds for CHUK

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CHUK

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CHUK Gene at Home site.
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CHUK Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CHUK

Summaries
for CHUK

Genomic Location
for CHUK

Proteins
for CHUK

Protein Domains/
Families
for CHUK

Gene Function
for CHUK

Pathways & Interactions
for CHUK

Drugs & Compounds
for CHUK

Transcripts
for CHUK

Expression
for CHUK

Orthologs
for CHUK

Paralogs
for CHUK

SNPs/Variants
for CHUK

Disorders & Mutations
for CHUK

Medical News
for CHUK

Publications
for CHUK

Search for CHUK

Genome Databases showing CHUK

Other Databases showing CHUK

Specialized Databases showing CHUK

Licensable Technologies
for CHUK

Services
for CHUK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CHUK (Gene Symbol)
EC 2.7.11.10
IKBKA
IKK-A
IKK-alpha
IKK1
IKKA
IkBKA
NFKBIKA
OTTHUMP00000020273
TCF16
I kappa-B kinase alpha
I-kappa-B kinase 1
I-kappa-B kinase-alpha
IKK-a kinase
IkB kinase alpha subunit
IkappaB kinase
Nuclear factor NF-kappa-B inhibitor kinase alpha
Nuclear factor NFkappaB inhibitor kinase alpha
conserved helix-loop ubiquitous kinase
conserved helix-loop-helix ubiquitous kinase

CHUK Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CHUK

Summariesfor CHUK

Genomic Locationfor CHUK

Proteinsfor CHUK

Protein Domains/Familiesfor CHUK

Gene Functionfor CHUK

Pathways & Interactionsfor CHUK

Drugs & Compoundsfor CHUK

Transcriptsfor CHUK

Expression for CHUK

Orthologsfor CHUK

Paralogsfor CHUK

SNPs/Variantsfor CHUK

Disorders & Mutationsfor CHUK

Medical Newsfor CHUK

Publicationsfor CHUK

Search for CHUK

Genome Databases showing CHUK

Other Databases showing CHUK

Specialized Databases showing CHUK

Licensable Technologiesfor CHUK

Servicesfor CHUK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CHUK

Summaries
for CHUK

Genomic Location
for CHUK

Proteins
for CHUK

Protein Domains/
Families
for CHUK

Gene Function
for CHUK

Pathways & Interactions
for CHUK

Drugs & Compounds
for CHUK

Transcripts
for CHUK

Expression
for CHUK

Orthologs
for CHUK

Paralogs
for CHUK

SNPs/Variants
for CHUK

Disorders & Mutations
for CHUK

Medical News
for CHUK

Publications
for CHUK

Licensable Technologies
for CHUK

Services
for CHUK