Aliases for CHUK Gene
Aliases for CHUK Gene
External Ids for CHUK Gene
- HGNC: 1974
- Entrez Gene: 1147
- Ensembl: ENSG00000213341
- OMIM: 600664
- UniProtKB: O15111
Previous HGNC Symbols for CHUK Gene
- TCF16
Previous GeneCards Identifiers for CHUK Gene
- GC10M100841
- GC10M101181
- GC10M102079
- GC10M101612
- GC10M101938
- GC10M095577
Summaries for CHUK Gene
-
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHUK Gene
CHUK (Conserved Helix-Loop-Helix Ubiquitous Kinase) is a Protein Coding gene. Diseases associated with CHUK include Cocoon Syndrome and Incontinentia Pigmenti. Among its related pathways are Activated TLR4 signalling and Interleukin-1 signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IKBKB.
UniProtKB/Swiss-Prot for CHUK Gene
-
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at Ser-10 that are subsequently acetylated at Lys-14 by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260).
-
IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The IKK complex is comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and beta-subunits are catalytically active whereas the gamma-subunit has a regulatory function.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHUK Gene
Genomics for CHUK Gene
Regulatory Elements for CHUK Gene
Enhancers for CHUK Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CHUK on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CHUK gene promoter:
Regulatory Element Products
Genomic Location for CHUK Gene
- Chromosome:
- 10
- Start:
- 100,186,113 bp from pter
- End:
- 100,229,619 bp from pter
- Size:
- 43,507 bases
- Orientation:
- Minus strand
Genomic View for CHUK Gene
Genes around CHUK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q24.31 by Ensembl
- 10q24.31 by Entrez Gene
- 10q24.31 by HGNC
CHUK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHUK Gene
Proteins for CHUK Gene
-
Protein details for CHUK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15111-IKKA_HUMAN
- Recommended name:
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Protein Accession:
- O15111
- O14666
- Q13132
- Q5W0I4
- Q92467
Protein attributes for CHUK Gene
- Size:
- 745 amino acids
- Molecular mass:
- 84640 Da
- Quaternary structure:
-
- Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex (PubMed:10195894, PubMed:12612076). The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65 (By similarity). Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP (PubMed:11971985). Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14 (PubMed:9751059). Directly interacts with TRPC4AP (By similarity). May interact with TRAF2 (PubMed:19150425). Interacts with NALP2 (PubMed:15456791). May interact with MAVS/IPS1 (PubMed:16177806). Interacts with ARRB1 and ARRB2 (PubMed:15173580). Interacts with NLRC5; prevents CHUK phosphorylation and kinase activity (PubMed:20434986). Interacts with PIAS1; this interaction induces PIAS1 phosphorylation (PubMed:17540171). Interacts with ZNF268 isoform 2; the interaction is further increased in a TNF-alpha-dependent manner (PubMed:23091055). Interacts with FOXO3 (PubMed:15084260).
Protein Expression for CHUK Gene
Selected DME Specific Peptides for CHUK Gene
- O15111:
-
- LKIVHILNMTSAKI
- QCVLDGVRG
- LQSRIERETGI
- DQGSLCTSFVGTLQYLAPEL
- HKIIDLGYAK
- QPFTWHEKIKKKD
- PLLAMEYC
- QGQRAAM
- YGISSEKML
- RLGTGGFGNV
- YSDSTEMVKI
- DSYMVYLFDKSKTVYEGPF
- RDLKPEN
- MESLEQRAIDLYKQLK
- KPENCCGLKES
- QQLKAKL
- NYIVQDSK
- LHENKIIHRD
- IIHRDLKPENIVLQ
- TVDYWSFGT
- GPFASRSLS
- AIKSCRLELS
- QDRVLKELFGHLSKLLGCKQKIIDLLP
Post-translational modifications for CHUK Gene
- (Microbial infection) Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.
- Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CHUK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CHUK
- R&D Systems Antibodies for CHUK (IKK alpha)
- Cell Signaling Technology (CST) Antibodies for CHUK (IKKA)
-
Custom Antibody ServicesOriGene Antibodies for CHUK
- AM06253SU-N
- AM06512SU-N
- AM06518SU-N
- AP01612PU-N
- AP02417PU-N
- AP02417PU-S
- AP02652PU-N
- AP02652PU-S
- AP06179PU-N
- AP07412PU-N
- AP07569SU-N
- AP20307PU-N
- AP20346PU-N
- AP20952PU-N
- AP20953PU-N
- AP21040PU-N
- AP21041PU-N
- AP22636SU-N
- AP55885PU-N
- AP55885PU-S
- AP55886PU-N
- AP55886PU-S
- SP1268P
- SP1509P
- TA305976
- TA305994
- TA305995
- TA311869
- TA311870
- TA311871
- TA311872
- TA319147
- TA321322
- TA321323
- TA325378
- TA325379
- TA325380
- TA325381
- TA325382
- TA325383
- TA326719
- TA327250
- TA336452
- TA350751
- Novus Biologicals Antibodies for CHUK
-
Abcam antibodies for CHUK
- Invitrogen Antibodies for CHUK
- antibodies-online Antibodies for CHUK: See all 342
- GeneTex CHUK antibody for CHUK
-
St John's Laboratory Antibodies for CHUK
-
Custom Antibody ServicesProSci Antibodies for CHUK
-
Santa Cruz Biotechnology (SCBT) Antibodies for CHUK
Protein Products
- EMD Millipore Purified and/or Recombinant CHUK Protein
-
OriGene Purified Proteins for CHUK
- Search Origene for MassSpec and Protein Over-expression Lysates for CHUK
- Origene Custom Protein Services for CHUK
- antibodies-online Proteins for CHUK: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CHUK
-
Abcam proteins for CHUK
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for CHUK (IKK alpha)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for CHUK (IKKA)
- antibodies-online Kits for CHUK: See all 11
Domains & Families for CHUK Gene
Gene Families for CHUK Gene
Protein Domains for CHUK Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CHUK Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O15111UniProtKB/Swiss-Prot:
IKKA_HUMAN :- The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
- Domain:
-
- The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
- Contains 1 protein kinase domain.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Function for CHUK Gene
Molecular function for CHUK Gene
- GENATLAS Biochemistry:
- I kappa B alpha-kinase inhibitor of kappa light polypeptide enhancer in B cells (NFKB),kinase alpha,activated by MEKK1,complexing with IKBKB
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated when phosphorylated and inactivated when dephosphorylated.
- UniProtKB/Swiss-Prot Function:
- Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at Ser-10 that are subsequently acetylated at Lys-14 by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260).
Enzyme Numbers (IUBMB) for CHUK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA,IDA | 20434986 |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 8246997 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008384 | IkappaB kinase activity | IEA,TAS | 18626576 |
Phenotypes for CHUK Gene
- MGI mutant phenotypes for CHUK:
-
inferred from 9 alleles
- cellular phenotype
- mortality/aging
- growth/size/body region phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- immune system phenotype
- cardiovascular system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- liver/biliary system phenotype
- integument phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- embryo phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for CHUK:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Transferrin accumulation in the perinuclear area
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased influenza A/WSN/33 replication
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
Animal Models for CHUK Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CHUK
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHUK
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHUK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHUK gene
- Search ViGene Biosciences for CHUK
CRISPR Products
-
OriGene CRISPR knockouts for CHUK
- GenScript: Design CRISPR guide RNA sequences for CHUK
miRNA for CHUK Gene
- miRTarBase miRNAs that target CHUK
miRNA Products
- Search ViGene Biosciences for CHUK
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CHUK
- VectorBuilder custom plasmid, inducible vectors for CHUK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHUK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CHUK
-
ViGene Biosciences adenoviral particle packaged cDNA for CHUK gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CHUK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHUK gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for CHUK Gene
Localization for CHUK Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHUK Gene
- Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | -- |
| GO:0005829 | cytosol | IEA,TAS | -- |
| GO:0008385 | IkappaB kinase complex | IEA,TAS | 18626576 |
Pathways & Interactions for CHUK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | TNFR1 Pathway |
.87
.87
.56
.55
.46
|
.40
.35
|
| 3 | 4-1BB Pathway |
.54
.54
.48
|
.37
.36
.30
|
| 4 | RET signaling |
.92
|
|
| 5 | Toll-Like receptor Signaling Pathways | ||
Pathways by source for CHUK Gene
2 GeneTex pathways for CHUK Gene
1 Cell Signaling Technology pathway for CHUK Gene
38 BioSystems pathways for CHUK Gene
79 Reactome pathways for CHUK Gene
36 KEGG pathways for CHUK Gene
45 GeneGo (Thomson Reuters) pathways for CHUK Gene
8 R&D Systems pathways for CHUK Gene
5 Tocris pathways for CHUK Gene
72 Qiagen pathways for CHUK Gene
Interacting Proteins for CHUK Gene
Selected Interacting proteins:
O15111-IKKA_HUMAN
ENSP00000359424
for CHUK Gene via
MINT
STRING
UniProtKB
IID
SIGNOR curated interactions for CHUK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0003009 | skeletal muscle contraction | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA,IDA | 20434986 |
| GO:0006954 | inflammatory response | TAS | 18626576 |
| GO:0006955 | immune response | TAS | 9346484 |
Drugs & Compounds for CHUK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sulfasalazine | Approved | Pharma | Inhibition, Inhibitor, Target, inhibitor | NF-κB activation inhibitor | 61 | |
| Aminosalicylic Acid | Approved | Pharma | Target, inhibitor | 28 | ||
| Mesalazine | Approved | Pharma | Target, inhibitor | 0 | ||
| Acetylcysteine | Approved | Pharma | Target, inhibitor | Antioxidant;mucolytic agent | 316 | |
| Adenosine triphosphate | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
(5) Tocris Compounds for CHUK Gene
| Compound | Action | Cas Number |
|---|---|---|
| ACHP | Selective IKKalpha and IKKbeta inhibitor | 406208-42-2 |
| Amlexanox | Inhibitor of TBK1 and IKKeta; antiallergic agent | 68302-57-8 |
| BMS 345541 | Selective allosteric inhibitor of IKK; anti-inflammatory | 547757-23-3 |
| PF 184 | Potent and selective IKKbeta inhibitor | 1187460-81-6 |
| PS 1145 dihydrochloride | Selective IKK inhibitor; orally active | 1049743-58-9 |
(12) ApexBio Compounds for CHUK Gene
| Compound | Action | Cas Number |
|---|---|---|
| Andrographolide | NF-κB signaling Inhibitor | 5508-58-7 |
| Bardoxolone methyl | IKK inhibitor, potent antioxidant inflammation modulator | 218600-53-4 |
| Bay 11-7085 | NK-κB activation inhibitor | 196309-76-9 |
| Bay 11-7821(BAY 11-7082) | IKK/NF-κB/TNFα inhibitor | 19542-67-7 |
| BMS-345541(free base) | IKK-1/IKK-2 inhibitor,potent and selective | 445430-58-0 |
| Honokiol | Antioxidant/antitumor/antiangiogenic agent | 35354-74-6 |
| IKK-16 (IKK Inhibitor VII) | Selective IκB kinase inhibitor | 873225-46-8 |
| IMD 0354 | 978-62-1 | |
| Luteolin | Antioxidant and free radical scavenger | 491-70-3 |
| Tanshinone IIA | Antioxidant and anti-inflammatory reagent | 568-72-9 |
| TPCA-1 | IKK-2 inhibitor,potent and selective | 507475-17-4 |
| WS6 | 1421227-53-3 |
Drug Products
- ApexBio compounds for CHUK
Transcripts for CHUK Gene
mRNA/cDNA for CHUK Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (357) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHUK Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHUK
- GenScript: Design CRISPR guide RNA sequences for CHUK
miRNA Products
- Search ViGene Biosciences for CHUK
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CHUK
- VectorBuilder custom plasmid, inducible vectors for CHUK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHUK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CHUK Gene
This gene is overexpressed in Peripheral blood mononuclear cells (25.2) and Lymph node (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHUK Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CHUK Gene:
CHUKSOURCE GeneReport for Unigene cluster for CHUK Gene:
Hs.198998mRNA Expression by UniProt/SwissProt for CHUK Gene:
O15111-IKKA_HUMAN
Tissue specificity:
Widely expressed.
Primer Products
-
OriGene qPCR primer pairs for CHUK
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHUK Gene
Orthologs for CHUK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHUK 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CHUK 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CHUK 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chuk 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Chuk 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CHUK 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CHUK 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHUK 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CHUK 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | chuk 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.31871 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | chuk 34 35 |
|
||
| zgc56539 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | ird5 36 35 |
|
- Species where no ortholog for CHUK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CHUK Gene
Variants for CHUK Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs267606736 | Pathogenic | 100,205,167(-) | TTATA(C/T)AGCTG | nc-transcript-variant, reference, stop-gained | |
| rs483352712 | Uncertain significance | 100,205,161(-) | AGCTG(C/G/T)GTAAA | nc-transcript-variant, reference, missense | |
| rs10549639 | -- | 100,190,021(+) | TATCC(-/T)TTTTT | intron-variant, downstream-variant-500B | |
| rs10632101 | -- | 100,217,073(+) | GATAT(-/CATA)CCAGG | intron-variant | |
| rs10883453 | -- | 100,208,164(+) | GCAGC(C/G)GCGTG | intron-variant |
Residual Variation Intolerance Score:
12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.53;
44.18% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CHUK Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHUK Gene
Disorders for CHUK Gene
(7) MalaCards diseases for CHUK Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cocoon syndrome |
|
|
| incontinentia pigmenti |
|
|
| ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive |
|
|
| popliteal pterygium syndrome 1 |
|
|
| human t-cell leukemia virus type 1 |
|
|
Search CHUK in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IKKA_HUMAN- Cocoon syndrome (COCOS) [MIM:613630]: A lethal syndrome characterized by multiple fetal malformations including defective face and seemingly absent limbs, which are bound to the trunk and encased under the skin. {ECO:0000269 PubMed:20961246}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CHUK
No data available for Genatlas for CHUK Gene
Publications for CHUK Gene
- The IkappaB kinase complex: master regulator of NF-kappaB signaling. (PMID: 18626576) Solt L.A. … May M.J. (Immunol. Res. 2008) 3 4 22 64
- Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. (PMID: 17434128) Huang W.C. … Chen C.C. (Mol. Cell 2007) 3 4 22 64
- IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression. (PMID: 16902410) Schneider G. … Schmid R.M. (EMBO J. 2006) 2 3 22 64
- NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. (PMID: 9520446) Ling L. … Goeddel D.V. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 22 64
- IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. (PMID: 9813230) Hu M.C.-T. … Wang Y.-P. (Gene 1998) 3 4 22 64
Products for CHUK Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CHUK
- EMD Millipore Purified and/or Recombinant CHUK Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for CHUK (IKK alpha)
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- Custom Antibody ServicesOriGene Antibodies for CHUK
- AM06253SU-N
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- Browse OriGene ELISA Kits
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- GeneTex CHUK antibody for CHUK
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- Mammalian expression: PiggyBac
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Sources for CHUK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (28) RNAdb
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- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
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- (60) miRBase
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- (62) NCBI
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- (69) Novus
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- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
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- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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