CHUK Gene
protein-coding GIFtS: 67
GCID: GC10M101938
|
|
conserved helix-loop-helix ubiquitous kinase
(Previous symbol: TCF16)
| |
Aliases
for CHUK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Conserved Helix-Loop-Helix Ubiquitous Kinase1 2 3 | | IKBKA2 5 | | IKK11 2 3 5 | | I-Kappa-B Kinase-Alpha2 | | IKKA1 2 3 5 | | IkB Kinase Alpha Subunit2 | | NFKBIKA1 2 3 5 | | IKK-A Kinase2 | | IKK-Alpha1 | | Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Alpha2 | | TCF161 2 3 | | Nuclear Factor NFkappaB Inhibitor Kinase Alpha2 | | IkBKA1 3 | | IKK-A3 | | Transcription Factor 162 3 | | I-Kappa-B Kinase Alpha3 | | TCF-162 3 | | IkappaB Kinase3 | | I-Kappa-B Kinase 12 3 | | Nuclear Factor NF-Kappa-B Inhibitor Kinase Alpha3 | | EC 2.7.11.103 8 | | EC 2.7.118 |
Export aliases for CHUK gene to outside databasesPrevious GC identifers: GC10M100841 GC10M101181 GC10M102079 GC10M101612 GC10M095577 |
Summaries
for CHUK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHUK:
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of acytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex,phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activatingthe transcription factor. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111Function: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiplestimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts aspart of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitorsof NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequentdegradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates thetranscription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of theA20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11).Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory geneactivation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimerphosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation ofNF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survivaland lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signalingpathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequentlyincreases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility atNF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3
 summary
for CHUK: IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The complex is
comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and
beta-subunits are catalytically active whereas the gamma-subunit serves a regulatory function. Activation of
NF-kappaB occurs via degradation of IkappaB, a process that is initiated by its phosphorylation by IkappaB
kinase (IKK). Phosphorylated IkappaB becomes dissociated from NF-kappaB, unmasking the NLS. Phosphorylation
also results in IkappaB ubiquitination and targeting to the proteasome. NF-kappaB can now enter the nucleus
and regulate gene expression.
Gene Wiki entry for CHUK
|
Genomic Views
for CHUK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHUK gene promoter:
Pax-5 FOXO3 POU6F1 (c2) LCR-F1 FOXO3b RORalpha1 PPAR-gamma1 c-Myb FOXO3a PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHUK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHUK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24-q25 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q24-q25CHUK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M101938: view genomic region
(about GC identifiers)
Start:
|
101,948,055 bp from pter |
End:
|
101,989,376 bp from pter |
Size:
|
41,322 bases |
Orientation:
|
minus strand |
|
Proteins
for CHUK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111 (See
protein sequence)Recommended Name: Inhibitor of nuclear factor kappa-B kinase subunit alpha Size: 745 amino acids; 84640 Da
Subunit: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably fouralpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associatewith regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates withTERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3,CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA,IKBKAP and MAP3K14. Directly interacts with IKK-gamma/NEMO and TRPC4AP (By similarity). May interact with TRAF2.Interacts with NALP2. May interact with MAVS/IPS1. Interacts with ARRB1 and ARRB2. Interacts with NLRC5; prevents CHUKphosphorylation and kinase activity. Interacts with PIAS1; this interaction induces PIAS1 phosphorylation
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus
1 PDB 3D structure from  and Proteopedia  for CHUK:3BRT (3D)
Secondary accessions: O14666 Q13132 Q5W0I4 Q92467Explore the universe of human proteins at neXtProt for CHUK: NX_O15111
Post-translational modifications:
Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated1
Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signalingpathway1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15111
4/23 DME Specific Peptides for CHUK (O15111) (see all 23)
CHUK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001269.3
ENSEMBL proteins: ENSP00000359424 Reactome Protein details: O15111
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
CHUK for ontologies About GeneDecksing
CHUK Antibody Products:
Assay Products for CHUK: |
Protein
Domains /
Families
for CHUK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHUK for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O15111ProtoNet protein and cluster: O15111 UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111Domain: The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- andhetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKGSimilarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CHUK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111Function: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiplestimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts aspart of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitorsof NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequentdegradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates thetranscription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of theA20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11).Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory geneactivation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimerphosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation ofNF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survivaland lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signalingpathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequentlyincreases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility atNF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3Catalytic activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]Enzyme regulation: Activated when phosphorylated and inactivated when dephosphorylated Genatlas biochemistry entry for CHUK:I kappa B alpha-kinase inhibitor of kappa light polypeptide enhancer in B cells (NFKB),kinase alpha,activated byMEKK1,complexing with IKBKB
Enzyme Numbers (IUBMB): EC 2.7.11.101 2 EC 2.7.112
Inhib. RNA
Products: |  | EMD Millipore RNAi Products for the Analysis of CHUK Gene knock-down | |  | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHUK (see all 7)
OriGene shRNA RFP: CHUK
OriGene siRNA: CHUK
| | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHUK |
Clone
Products: | | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHUK (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHUK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHUK (NM_001278) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHUK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHUK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHUK |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
CHUK for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for CHUK:
Animal Models:
Mouse knock-outs for CHUK: Chuktm1Ver Chuktm1.1Mpa Chuktm1Aki
15/22 MGI mutant phenotypes (inferred from 8 alleles ) (MGI details for Chuk) (see all 22):
CHUK for phenotypes About GeneDecksing
|
Pathways & Interactions
for CHUK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/116 super-pathways (see all 116) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | TWEAK Pathway | | | 3 | Signaling by FGFR | | | 4 | PIP3 activates AKT signaling | | | 5 | 4-1BB Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/35 EMD Millipore Pathways for CHUK (see all 35)
2  R&D Systems Pathways for CHUK
5/72 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CHUK (see all 72)
1 
Cell Signaling Technology (CST) Pathway for CHUK
5 Tocris Bioscience Pathways for CHUK
5/45  GeneGo (Thomson Reuters) Pathways for CHUK (see all 45)
5/34  BioSystems Pathways for CHUK (see all 34)
5/68 
Reactome Pathways for CHUK (see all 68)
5/23 
Kegg Pathways (Kegg details for CHUK) (see all 23):
CHUK for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHUK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/219 Interacting proteins for CHUK (O151111, 2, 3 ENSP000003594244) via UniProtKB, MINT, STRING, and/or I2D (see all 219)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| IKBKG | Q9Y6K91, 2, 3, ENSP000003586224 | EBI-81249,EBI-356130 MINT-4652844 MINT-3089462 MINT-48137 MINT-47970 MINT-5115028 I2D:
score=9 STRING: ENSP00000358622 | | RELA | Q042061, 2, 3, ENSP000003842734 | EBI-81249,EBI-73886 MINT-48009 MINT-50107 MINT-48896 I2D:
score=7 STRING: ENSP00000384273 | | MAP3K14 | Q995581, 2, 3 | EBI-81249,EBI-358011 MINT-48791 MINT-47999 MINT-1955970 I2D:
score=7 | | IKBKB | O149201, 2, 3, ENSP000003391514 | EBI-81249,EBI-81266 MINT-47955 MINT-48069 I2D:
score=11 STRING: ENSP00000339151 | | NFKB1 | P198382, 3, ENSP000002265744 | MINT-47906 MINT-47887 MINT-48533 MINT-48643 I2D:
score=5 STRING: ENSP00000226574 |
About this table
Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002011 | morphogenesis of an epithelial sheet |
IEA | -- | | GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
TAS | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- | | GO:0003009 | skeletal muscle contraction |
IEA | -- |
CHUK for ontologies About GeneDecksing
|
Drugs & Compounds
for CHUK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CHUK for compounds About GeneDecksing
Compounds for CHUK available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| IKK 16 | Selective inhibitor of IKK | -- |
2 HMDB Compounds for CHUK About this table
3 DrugBank Compounds for CHUK About this table
10/87 Novoseek chemical compound relationships for CHUK gene (see all 87) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tab-2 |
82.7 |
1 |
15836773 (1) |
| tab-1 |
73.4 |
3 |
10187861 (2), 17633026 (1) |
| acetyl-11-keto-beta-boswellic acid |
65 |
1 |
18032778 (1) |
| parthenolide |
61.9 |
7 |
10553091 (1), 15618150 (1), 17436572 (1), 15467918 (1) (see all 6) |
| geldanamycin |
59.9 |
11 |
10744744 (2), 15077173 (2), 17088896 (1), 15930313 (1) (see all 6) |
| helenalin |
58.5 |
4 |
20175984 (2), 20069553 (1) |
| bortezomib |
56 |
1 |
19436050 (1) |
| ppme |
54.9 |
1 |
9915837 (1) |
| pdtc |
49.9 |
9 |
12584727 (1), 19399830 (1), 16490171 (1), 16998220 (1) (see all 6) |
| guggulsterone |
47.7 |
1 |
17119390 (1) |
Search CenterWatch for drugs/clinical trials and news about CHUK / IKKA
|
Transcripts
for CHUK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHUK gene: NM_001278.3 Unigene Cluster for CHUK: Conserved helix-loop-helix ubiquitous kinase Hs.198998 [show with all ESTs]Unigene Representative Sequence: AB2090284 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370397(uc001kqp.3) ENST00000590930 ENST00000588656 ENST00000585551
Inhib. RNA
Products: | | EMD Millipore RNAi Products for the Analysis of CHUK Gene knock-down | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHUK (see all 7)
OriGene shRNA RFP: CHUK
OriGene siRNA: CHUK
| | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHUK |
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHUK (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHUK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHUK (NM_001278) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHUK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHUK |
Additional cDNA sequence: AB209028.1 AF009225.1 AF012890.1 AF080157.1 AY952888.2 BC034796.1 BC092514.1 U22512.1 8 DOTS entries: DT.100814684 DT.454093 DT.101978418 DT.100675447 DT.98083593 DT.92037566 DT.95162259 DT.100814686 24/357 AceView cDNA sequences (see all 357): CA397884 AA574067 BM835165 AF064093 CR626509 AJ289817 AU280728 BU729203 N94750 AU279637 CN482133 BM466809 BE219160 AI300129 CB988839 AW953039 BM797027 BQ228965 BM552188 CN479910 CR607760 AF012890 BX383252 CK823085
GeneLoc Exon Structure
|
Expression
for CHUK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHUK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACCATTCT
About this image
See CHUK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHUK
SOURCE GeneReport for Unigene cluster: Hs.198998
UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111Tissue specificity: Widely expressed
SABiosciences Expression via Pathway-Focused PCR Arrays including CHUK (see all 12):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHUK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHUK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHUK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHUK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHUK |
Orthologs
for CHUK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CHUK gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Chuk1 , 5 |
conserved helix-loop-helix ubiquitous kinase1, 5 |
92.44(n)1
95.3(a)1 |
|
19 (36.71 cM)5
126751 NM_007700.21 NP_031726.21
440733355 |
chicken
(Gallus gallus) |
Aves |
CHUK1 |
conserved helix-loop-helix ubiquitous kinase |
76.33(n)
81.17(a) |
|
423669 NM_001012904.1 NP_001012922.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CHUK6 |
-- |
83(a) |
1 ↔ 1 |
GL343297.1(1223372-1262931) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.318712 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.34(n) |
|
AW159773.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc565392 |
hypothetical protein MGC56539 |
73.41(n) |
|
393287 BC051614.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ird53 |
antibacterial humoral response (sensu
Invertebrata) more |
32(a) |
|
89B3 -- |
ENSEMBL Gene Tree for CHUK (if available)
TreeFam Gene Tree for CHUK (if available) |
Paralogs
for CHUK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHUK gene
- IKBKB2 IKBKE2 TBK12
7 SIMAP similar genes for CHUK using alignment to 2 protein entries: IKKA_HUMAN (see all proteins):IKBKB RPS6KA2 NUAK1 DKFZp564L2416 MARK4 CDK4
STK11
CHUK for paralogs About GeneDecksing
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Genomic Variants
for CHUK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHUK (101948055 - 101989376 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHUK: --
Human Gene Mutation Database (HGMD): CHUK
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHUK |
|
Disorders
/ Diseases
for CHUK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHUK for disorders About GeneDecksing
OMIM gene information: 600664
OMIM disorders: 613630
UniProtKB/Swiss-Prot: IKKA_HUMAN, O15111
Defects in CHUK are the cause of cocoon syndrome (COCOS) [MIM:613630]; also known as fetal encasementsyndrome. COCOS is a lethal syndrome characterized by multiple fetal malformations including defective face andseemingly absent limbs, which are bound to the trunk and encased under the skin
20/97  diseases for CHUK (see all 97): About MalaCardsestrogen-receptor negative breast cancer diffuse large b-cell lymphoma human t-cell leukemia virus type 1 multidrug-resistant tuberculosis
ectodermal dysplasia b-cell lymphomas salivary gland cancer non-hodgkin lymphoma
cocoon syndrome ataxia telangiectasia chronic obstructive pulmonary disease oral squamous cell carcinoma
mantle cell lymphoma fatty liver disease systemic lupus erythematosus cystic fibrosis
squamous cell carcinoma myeloid leukemia skin papilloma lupus erythematosus
10/43 Novoseek disease relationships for CHUK gene (see all 43) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
73.6 |
65 |
11054378 (2), 17897950 (2), 9710600 (1), 10542212 (1) (see all 55) |
| tumors |
63.6 |
105 |
19074890 (4), 11054378 (2), 11752211 (2), 17644309 (2) (see all 74) |
| leukemia t-cell |
63.5 |
10 |
9710600 (1), 11064457 (1), 11726516 (1), 16611882 (1) (see all 9) |
| ectodermal dysplasia, hypohidrotic |
59 |
2 |
14734108 (1), 14523047 (1) |
| inflammation |
59 |
20 |
17371257 (2), 16009742 (1), 9520464 (1), 18163512 (1) (see all 18) |
| cancer |
42.3 |
19 |
19116119 (2), 18831712 (1), 19946332 (1), 17277159 (1) (see all 14) |
| ataxia telangiectasia |
30.2 |
2 |
17700524 (1), 16497931 (1) |
| lymphoma b-cell |
24.1 |
1 |
15671525 (1) |
| ectodermal dysplasia |
23.1 |
6 |
18633439 (4) |
| lymphoma |
20.4 |
2 |
17237443 (1), 20516126 (1) |
Human Genome Epidemiology (HuGE) Navigator: CHUK (32 documents)
Export disorders for CHUK gene to outside databases
|
Publications
for CHUK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHUK gene, integrated from 9 sources (see all 848):
(articles sorted by number of sources associating them with CHUK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. (PubMed id 9520446)1, 2, 9 Ling L.... Goeddel D.V. (1998)
- The IkappaB kinase complex: master regulator of NF-kappaB signaling. (PubMed id 18626576)1, 2, 9 Solt L.A. and May M.J. (2008)
- IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. (PubMed id 9813230)1, 2, 9 Hu M.C.-T. and Wang Y.-P. (1998)
- IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF- kappaB activation. (PubMed id 9346484)1, 2, 9 Mercurio F.... Rao A. (1997)
- Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. (PubMed id 17434128)1, 2, 9 Huang W.C....Chen C.C. (2007)
- IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression. (PubMed id 16902410)1, 3, 9 Schneider G....Schmid R.M. (2006)
- Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. (PubMed id 9819420)1, 2, 9 Nemoto S.... Lin A. (1998)
- Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. (PubMed id 20501937)1, 2, 9 Razani B....Cheng G. (2010)
- Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation. (PubMed id 12612076)1, 2, 9 Tegethoff S....Scheidereit C. (2003)
- Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. (PubMed id 10195894)1, 2, 9 Delhase M.... Karin M. (1999)
|
External Searches for CHUK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHUK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHUK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHUK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CHUK gene:
Search GeneIP for patents involving CHUK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHUK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CHUK | | OriGene shRNA RFP for CHUK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHUK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHUK | | | OriGene Protein Over-expression Lysate for CHUK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHUK | | OriGene 3'-UTR Clone for CHUK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHUK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHUK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHUK | | OriGene Custom Protein Services for CHUK | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHUK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHUK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHUK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHUK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHUK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHUK |
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| | Antibodies & Assays for CHUK (IKK-alpha) |
| | | | Tocris compounds for CHUK |
| |  |  |  |  | | | | |
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 | | | CHUK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHUK |
|  |  |  | | | | ThermoFisher Antibody for CHUK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHUK |
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