Aliases for CHUK Gene
Aliases for CHUK Gene
External Ids for CHUK Gene
- HGNC: 1974
- Entrez Gene: 1147
- Ensembl: ENSG00000213341
- OMIM: 600664
- UniProtKB: O15111
Previous HGNC Symbols for CHUK Gene
- TCF16
Previous GeneCards Identifiers for CHUK Gene
- GC10M100841
- GC10M101181
- GC10M102079
- GC10M101612
- GC10M101938
- GC10M095577
Summaries for CHUK Gene
-
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHUK Gene
CHUK (Conserved Helix-Loop-Helix Ubiquitous Kinase) is a Protein Coding gene. Diseases associated with CHUK include Cocoon Syndrome and Helicobacter Pylori Infection. Among its related pathways are Development EGFR signaling via small GTPases and Constitutive Signaling by AKT1 E17K in Cancer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IKBKB.
UniProtKB/Swiss-Prot for CHUK Gene
-
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at Ser-10 that are subsequently acetylated at Lys-14 by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260).
-
IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The IKK complex is comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and beta-subunits are catalytically active whereas the gamma-subunit has a regulatory function.
Additional gene information for CHUK Gene
- Monarch Initiative
- Search for CHUK at DataMed
- Search for CHUK at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHUK Gene
Genomics for CHUK Gene
GeneHancer (GH) Regulatory Elements for CHUK Gene
Promoters and enhancers for CHUK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CHUK on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CHUK gene promoter:
Regulatory Element Products
Genomic Locations for CHUK Gene
Genomic Locations for CHUK Gene
- chr10:100,186,113-100,229,619
- (GRCh38/hg38)
- Size:
- 43,507 bases
- Orientation:
- Minus strand
- chr10:101,948,055-101,989,376
- (GRCh37/hg19)
Genomic View for CHUK Gene
Genes around CHUK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q24.31 by Ensembl
- 10q24.31 by Entrez Gene
- 10q24.31 by HGNC
CHUK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHUK Gene
Proteins for CHUK Gene
-
Protein details for CHUK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15111-IKKA_HUMAN
- Recommended name:
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Protein Accession:
- O15111
- O14666
- Q13132
- Q5W0I4
- Q92467
Protein attributes for CHUK Gene
- Size:
- 745 amino acids
- Molecular mass:
- 84640 Da
- Quaternary structure:
-
- Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex (PubMed:10195894, PubMed:12612076). The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65 (By similarity). Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP (PubMed:11971985). Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, ELP1 and MAP3K14 (PubMed:9751059). Directly interacts with TRPC4AP (By similarity). May interact with TRAF2 (PubMed:19150425). Interacts with NALP2 (PubMed:15456791). May interact with MAVS/IPS1 (PubMed:16177806). Interacts with ARRB1 and ARRB2 (PubMed:15173580). Interacts with NLRC5; prevents CHUK phosphorylation and kinase activity (PubMed:20434986). Interacts with PIAS1; this interaction induces PIAS1 phosphorylation (PubMed:17540171). Interacts with ZNF268 isoform 2; the interaction is further increased in a TNF-alpha-dependent manner (PubMed:23091055). Interacts with FOXO3 (PubMed:15084260). Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation (PubMed:26334375). Interacts with LRRC14 (PubMed:27426725).
Protein Expression for CHUK Gene
Selected DME Specific Peptides for CHUK Gene
- O15111:
-
- LKIVHILNMTSAKI
- QCVLDGVRG
- LQSRIERETGI
- DQGSLCTSFVGTLQYLAPEL
- HKIIDLGYAK
- QPFTWHEKIKKKD
- PLLAMEYC
- QGQRAAM
- YGISSEKML
- RLGTGGFGNV
- YSDSTEMVKI
- DSYMVYLFDKSKTVYEGPF
- RDLKPEN
- MESLEQRAIDLYKQLK
- KPENCCGLKES
- QQLKAKL
- NYIVQDSK
- LHENKIIHRD
- IIHRDLKPENIVLQ
- TVDYWSFGT
- GPFASRSLS
- AIKSCRLELS
- QDRVLKELFGHLSKLLGCKQKIIDLLP
Post-translational modifications for CHUK Gene
- (Microbial infection) Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.
- Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
Other Protein References for CHUK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CHUK (IKK alpha)
- Cell Signaling Technology (CST) Antibodies for CHUK (IKKA)
-
Custom Antibody ServicesOriGene Antibodies for CHUK
- AM06253SU-N
- AM06512SU-N
- AM06518SU-N
- AP01612PU-N
- AP02417PU-N
- AP02417PU-S
- AP02652PU-N
- AP02652PU-S
- AP06179PU-N
- AP07569SU-N
- AP20307PU-N
- AP20346PU-N
- AP20952PU-N
- AP20953PU-N
- AP21040PU-N
- AP21041PU-N
- AP55885PU-N
- AP55885PU-S
- AP55886PU-N
- AP55886PU-S
- SP1268P
- SP1509P
- TA305976
- TA305994
- TA305995
- TA311872
- TA319147
- TA321322
- TA321323
- TA325378
- TA325379
- TA325380
- TA325381
- TA325382
- TA325383
- TA326719
- TA327250
- TA336452
- TA350751
- Novus Biologicals Antibodies for CHUK
-
Abcam antibodies for CHUK
- Invitrogen Antibodies for CHUK
- antibodies-online: Search results for 371 available CHUK Antibodies ranked by validation data
- Compare Top CHUK Antibodies
-
Recommended
- 302 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 CP Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 116 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 6 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 70 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 5 IHC (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- GeneTex CHUK antibody for CHUK
-
Santa Cruz Biotechnology (SCBT) Antibodies for CHUK
Protein Products
-
OriGene Purified Proteins for CHUK
- Search Origene for MassSpec and Protein Over-expression Lysates for CHUK
- Origene Custom Protein Services for CHUK
- Search GeneTex for Proteins for CHUK
-
Abcam proteins for CHUK
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for CHUK (IKK alpha)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for CHUK (IKKA)
Domains & Families for CHUK Gene
Gene Families for CHUK Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for CHUK Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CHUK Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O15111UniProtKB/Swiss-Prot:
IKKA_HUMAN :- The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
- Domain:
-
- The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Function for CHUK Gene
Molecular function for CHUK Gene
- GENATLAS Biochemistry:
- I kappa B alpha-kinase inhibitor of kappa light polypeptide enhancer in B cells (NFKB),kinase alpha,activated by MEKK1,complexing with IKBKB
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated when phosphorylated and inactivated when dephosphorylated.
- UniProtKB/Swiss-Prot Function:
- Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at Ser-10 that are subsequently acetylated at Lys-14 by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260).
Enzyme Numbers (IUBMB) for CHUK Gene
Phenotypes From GWAS Catalog for CHUK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IDA | 20434986 |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 8246997 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008384 | IkappaB kinase activity | TAS | 18626576 |
Phenotypes for CHUK Gene
- MGI mutant phenotypes for CHUK:
-
inferred from 9 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for CHUK:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Transferrin accumulation in the perinuclear area
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased influenza A/WSN/33 replication
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
Animal Models for CHUK Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHUK
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHUK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHUK gene
- Search ViGene Biosciences for CHUK
CRISPR Products
-
OriGene CRISPR knockouts for CHUK
- genomics-online: gRNA clones - Search results for 100 available CHUK gene related products
- Overview of 100 available CHUK gene related products
- Applied Biological Materials CRISPR for CHUK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHUK
- GenScript: Design CRISPR guide RNA sequences for CHUK
miRNA for CHUK Gene
- miRTarBase miRNAs that target CHUK
miRNA Products
- Search ViGene Biosciences for CHUK
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHUK
- Browse OriGene Inhibitory RNA Products For CHUK
- genomics-online: shRNA clones - Search results for 100 available CHUK gene related products
- Overview of 100 available CHUK gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CHUK gene
Clone Products
- Sino Biological Human cDNA Clone for CHUK
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHUK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHUK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CHUK
- Applied Biological Materials Clones for CHUK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CHUK
-
ViGene Biosciences adenoviral particle packaged cDNA for CHUK gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CHUK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHUK gene
No data available for Transcription Factor Targets and HOMER Transcription for CHUK Gene
Localization for CHUK Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHUK Gene
- Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | TAS | 9252186 |
| GO:0005829 | cytosol | IEA,TAS | -- |
| GO:0008385 | IkappaB kinase complex | TAS,IEA | 18626576 |
Pathways & Interactions for CHUK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | TNFR1 Pathway |
.87
.87
.56
.55
.46
|
.40
.35
|
| 3 | 4-1BB Pathway |
.54
.54
.48
|
.37
.36
.30
|
| 4 | RET signaling |
.92
|
|
| 5 | Cytosolic sensors of pathogen-associated DNA | ||
Pathways by source for CHUK Gene
2 GeneTex pathways for CHUK Gene
1 Cell Signaling Technology pathway for CHUK Gene
46 BioSystems pathways for CHUK Gene
79 Reactome pathways for CHUK Gene
40 KEGG pathways for CHUK Gene
45 GeneGo (Thomson Reuters) pathways for CHUK Gene
6 R&D Systems pathways for CHUK Gene
5 Tocris pathways for CHUK Gene
72 Qiagen pathways for CHUK Gene
Interacting Proteins for CHUK Gene
Selected Interacting proteins:
O15111-IKKA_HUMAN
ENSP00000359424
for CHUK Gene via
MINT
STRING
IID
UniProtKB
SIGNOR curated interactions for CHUK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | -- |
| GO:0003009 | skeletal muscle contraction | IEA | -- |
| GO:0006468 | protein phosphorylation | IDA | 20434986 |
Drugs & Compounds for CHUK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sulfasalazine | Approved | Pharma | Inhibition, Inhibitor, Target, inhibitor | NF-κB activation inhibitor | 63 | |
| Aminosalicylic Acid | Approved | Pharma | Target, inhibitor | 31 | ||
| Mesalazine | Approved | Pharma | Target, inhibitor | 0 | ||
| Acetylcysteine | Approved, Investigational | Pharma | Target, inhibitor | Antioxidant;mucolytic agent | 352 | |
| Amlexanox | Approved, Investigational | Pharma | Inhibitor of TBK1 and IKKepsilon; antiallergic agent | 3 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
(3) Tocris Compounds for CHUK Gene
(12) ApexBio Compounds for CHUK Gene
| Compound | Action | Cas Number |
|---|---|---|
| Andrographolide | NF-κB signaling Inhibitor | 5508-58-7 |
| Bardoxolone methyl | IKK inhibitor, potent antioxidant inflammation modulator | 218600-53-4 |
| Bay 11-7085 | NK-κB activation inhibitor | 196309-76-9 |
| Bay 11-7821(BAY 11-7082) | IKK/NF-κB/TNFα inhibitor | 19542-67-7 |
| BMS-345541(free base) | IKK-1/IKK-2 inhibitor,potent and selective | 445430-58-0 |
| Honokiol | Antioxidant/antitumor/antiangiogenic agent | 35354-74-6 |
| IKK-16 (IKK Inhibitor VII) | Selective IκB kinase inhibitor | 873225-46-8 |
| IMD 0354 | 978-62-1 | |
| Luteolin | Antioxidant and free radical scavenger | 491-70-3 |
| Tanshinone IIA | Antioxidant and anti-inflammatory reagent | 568-72-9 |
| TPCA-1 | IKK-2 inhibitor,potent and selective | 507475-17-4 |
| WS6 | 1421227-53-3 |
Transcripts for CHUK Gene
mRNA/cDNA for CHUK Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (357) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHUK Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHUK
- genomics-online: gRNA clones - Search results for 100 available CHUK gene related products
- Overview of 100 available CHUK gene related products
- Applied Biological Materials CRISPR for CHUK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHUK
- GenScript: Design CRISPR guide RNA sequences for CHUK
miRNA Products
- Search ViGene Biosciences for CHUK
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHUK
- Browse OriGene Inhibitory RNA Products For CHUK
- genomics-online: shRNA clones - Search results for 100 available CHUK gene related products
- Overview of 100 available CHUK gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CHUK gene
Clone Products
- Sino Biological Human cDNA Clone for CHUK
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHUK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHUK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CHUK
- Applied Biological Materials Clones for CHUK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CHUK Gene
This gene is overexpressed in Peripheral blood mononuclear cells (25.2) and Lymph node (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHUK Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CHUK Gene:
CHUKSOURCE GeneReport for Unigene cluster for CHUK Gene:
Hs.198998mRNA Expression by UniProt/SwissProt for CHUK Gene:
O15111-IKKA_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for CHUK Gene
- Blood(4.4)
- Heart(4.3)
- Intestine(2.1)
- Skin(2.1)
- Liver(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CHUK Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- reproductive
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- ear
- head
- inner ear
- jaw
- mandible
- maxilla
- middle ear
- mouth
- outer ear
- skull
- tongue
- tooth
Abdomen:
- abdominal wall
- intestine
- large intestine
- liver
- small intestine
Pelvis:
- penis
- testicle
- vulva
Limb:
- lower limb
- upper limb
General:
- skin
- sweat gland
Primer Products
-
OriGene qPCR primer pairs for CHUK
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHUK Gene
Orthologs for CHUK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHUK 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CHUK 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CHUK 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chuk 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Chuk 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CHUK 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CHUK 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHUK 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CHUK 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | chuk 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.31871 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | chuk 33 34 |
|
||
| zgc56539 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | ird5 35 34 |
|
- Species where no ortholog for CHUK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CHUK Gene
Variants for CHUK Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs267606736 | pathogenic, Cocoon syndrome | 100,205,167(-) | G/A | coding_sequence_variant, non_coding_transcript_variant, stop_gained | |
| rs483352712 | uncertain-significance, not provided | 100,205,161(-) | G/A/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1057524734 | uncertain-significance, not specified | 100,194,000(-) | A/C | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1000008521 | -- | 100,198,246(-) | A/G | 3_prime_UTR_variant, intron_variant | |
| rs1000110110 | -- | 100,206,050(-) | C/G | intron_variant |
Residual Variation Intolerance Score:
12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.53;
44.18% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CHUK Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHUK Gene
Disorders for CHUK Gene
(8) MalaCards diseases for CHUK Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cocoon syndrome |
|
|
| helicobacter pylori infection |
|
|
| ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive |
|
|
| popliteal pterygium syndrome |
|
|
| incontinentia pigmenti |
|
|
Search CHUK in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IKKA_HUMAN- Cocoon syndrome (COCOS) [MIM:613630]: A lethal syndrome characterized by multiple fetal malformations including defective face and seemingly absent limbs, which are bound to the trunk and encased under the skin. {ECO:0000269 PubMed:20961246}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for CHUK
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CHUK Gene
Publications for CHUK Gene
- The IkappaB kinase complex: master regulator of NF-kappaB signaling. (PMID: 18626576) Solt LA … May MJ (Immunologic research 2008) 3 4 22 58
- Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. (PMID: 17434128) Huang WC … Chen CC (Molecular cell 2007) 3 4 22 58
- IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression. (PMID: 16902410) Schneider G … Schmid RM (The EMBO journal 2006) 2 3 22 58
- NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. (PMID: 9520446) Ling L … Goeddel DV (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 58
- IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. (PMID: 9813230) Hu MC … Wang Y (Gene 1998) 3 4 22 58
Products for CHUK Gene
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- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CHUK
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- Find your target
- Browse Primary Antibodies
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- Cyagen custom Knockout/knockin (KOKI) mouse models for CHUK
- VectorBuilder custom plasmid, inducible vectors for CHUK
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CHUK
- antibodies-online: Search results for 371 available CHUK Antibodies ranked by validation data
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- 302 WB Antibodies (anti-human)
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- 1 CP Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 116 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 6 IHC (p) Antibodies (anti-mouse)
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- 70 WB Antibodies (anti-rat)
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