Aliases for CHTOP Gene
Aliases for CHTOP Gene
External Ids for CHTOP Gene
- HGNC: 24511
- Entrez Gene: 26097
- Ensembl: ENSG00000160679
- OMIM: 614206
- UniProtKB: Q9Y3Y2
Previous HGNC Symbols for CHTOP Gene
- C1orf77
Previous GeneCards Identifiers for CHTOP Gene
- GC01P153607
Summaries for CHTOP Gene
-
This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for CHTOP Gene
CHTOP (Chromatin Target Of PRMT1) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. GO annotations related to this gene include poly(A) RNA binding.
UniProtKB/Swiss-Prot for CHTOP Gene
-
Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).
-
Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHTOP Gene
Genomics for CHTOP Gene
Regulatory Elements for CHTOP Gene
Enhancers for CHTOP Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CHTOP on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CHTOP Gene
- Chromosome:
- 1
- Start:
- 153,633,982 bp from pter
- End:
- 153,646,306 bp from pter
- Size:
- 12,325 bases
- Orientation:
- Plus strand
Genomic View for CHTOP Gene
Genes around CHTOP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
CHTOP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHTOP Gene
Proteins for CHTOP Gene
-
Protein details for CHTOP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3Y2-CHTOP_HUMAN
- Recommended name:
- Chromatin target of PRMT1 protein
- Protein Accession:
- Q9Y3Y2
- D3DV55
- Q0VAQ8
- Q2VPI9
- Q5T7Y8
- Q5T7Y9
- Q5T7Z0
- Q6NSM4
- Q6PB28
- Q8WYT9
- Q9BUC5
- Q9H034
- Q9H2L0
Protein attributes for CHTOP Gene
- Size:
- 248 amino acids
- Molecular mass:
- 26397 Da
- Quaternary structure:
-
- Interacts with PRMT1 and PRMT5 (PubMed:25284789). Interacts with the 5FMC complex; the interaction is methylation-dependent. Interacts with FYTTD1, SET and PRC1 complex members CBX4, RNF2 and PHC2; the interactions are methylation-independent. Interacts with ZNF148 (By similarity). Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts (methylated) with ALYREF/THOC4 and with DDX39B in a methylation-independent manner. Interacts (methylated) with NXF1; the interaction is mutually exclusive with the NXF1:THOC5 interaction (PubMed:23299939, PubMed:23826332). Interacts with WDR77 and ERH (PubMed:25284789).
- SequenceCaution:
-
- Sequence=AAH02733.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH70027.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL55869.1; Type=Frameshift; Positions=181; Evidence={ECO:0000305};
Protein Expression for CHTOP Gene
Post-translational modifications for CHTOP Gene
- Asymmetrically methylated by PRMT1 (PubMed:25284789). Symmetrically methylated by PRMT5 (By similarity).
- Ubiquitination at posLast=1616, posLast=8181, and Lys226
- Modification sites at PhosphoSitePlus
Other Protein References for CHTOP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CHTOP
-
Custom Antibody ServicesOriGene Antibodies for CHTOP
- Novus Biologicals Antibodies for CHTOP
- Invitrogen Antibodies for CHTOP
- antibodies-online Antibodies for CHTOP: See all 35
- GeneTex CHTOP antibody for CHTOP
Protein Products
-
OriGene Purified Proteins for CHTOP
- Search Origene for MassSpec and Protein Over-expression Lysates for CHTOP
- Origene Custom Protein Services for CHTOP
- antibodies-online Proteins for CHTOP: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CHTOP
Assay Products
- antibodies-online Kits for CHTOP: See all 4
No data available for DME Specific Peptides for CHTOP Gene
Domains & Families for CHTOP Gene
Suggested Antigen Peptide Sequences for CHTOP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CHTOP Gene
Function for CHTOP Gene
Molecular function for CHTOP Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).
- UniProtKB/Swiss-Prot Function:
- Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA,IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 14667819 |
| GO:0008327 | methyl-CpG binding | IDA | 25284789 |
Phenotypes for CHTOP Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHTOP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHTOP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHTOP gene
- Search ViGene Biosciences for CHTOP
CRISPR Products
-
OriGene CRISPR knockouts for CHTOP
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHTOP
- GenScript: Design CRISPR guide RNA sequences for CHTOP
miRNA for CHTOP Gene
- miRTarBase miRNAs that target CHTOP
-
- hsa-mir-155-5p (MIRT020760)
- hsa-mir-296-3p (MIRT038414)
- hsa-mir-193b-3p (MIRT041594)
- hsa-mir-186-5p (MIRT045224)
- hsa-mir-197-3p (MIRT048090)
- hsa-mir-92a-3p (MIRT049707)
- hsa-let-7a-5p (MIRT266622)
- hsa-let-7b-5p (MIRT266623)
- hsa-let-7c-5p (MIRT266624)
- hsa-let-7d-5p (MIRT266625)
- hsa-let-7e-5p (MIRT266626)
- hsa-let-7f-5p (MIRT266627)
- hsa-mir-98-5p (MIRT266628)
- hsa-let-7g-5p (MIRT266629)
- hsa-let-7i-5p (MIRT266630)
- hsa-mir-609 (MIRT266631)
- hsa-mir-4257 (MIRT266632)
- hsa-mir-4458 (MIRT266634)
- hsa-mir-4500 (MIRT266635)
- hsa-mir-6077 (MIRT266636)
- hsa-mir-6804-5p (MIRT266638)
- hsa-mir-8065 (MIRT266641)
- hsa-mir-586 (MIRT333277)
- hsa-mir-5700 (MIRT333285)
- hsa-mir-1287-3p (MIRT704672)
- hsa-mir-4457 (MIRT704673)
- hsa-mir-6876-5p (MIRT704674)
- hsa-mir-4476 (MIRT704675)
- hsa-mir-449b-3p (MIRT704676)
miRNA Products
- Search ViGene Biosciences for CHTOP
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHTOP
- Browse OriGene Inhibitory RNA Products For CHTOP
-
ViGene Biosciences ready-to-package AAV shRNAs for CHTOP gene
Clone Products
- Sino Biological Human cDNA Clone for CHTOP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHTOP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHTOP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CHTOP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CHTOP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHTOP gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHTOP Gene
Localization for CHTOP Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHTOP Gene
- Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332). {ECO:0000250 UniProtKB:Q9CY57, ECO:0000269 PubMed:23826332}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000346 | transcription export complex | IDA | 23299939 |
| GO:0000932 | P-body | IDA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IEA | -- |
Pathways & Interactions for CHTOP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RNA Polymerase II Transcription Termination | ||
| 2 | Transport of Mature Transcript to Cytoplasm | ||
| 3 | Gene Expression |
.48
|
|
| 4 | mRNA Splicing - Major Pathway | ||
| 5 | Formation of HIV elongation complex in the absence of HIV Tat | ||
Pathways by source for CHTOP Gene
Interacting Proteins for CHTOP Gene
Selected Interacting proteins:
ENSP00000357683
Q9Y3Y2-CHTOP_HUMAN
for CHTOP Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006369 | termination of RNA polymerase II transcription | TAS | -- |
| GO:0006405 | RNA export from nucleus | TAS | -- |
| GO:0006406 | mRNA export from nucleus | TAS | -- |
No data available for SIGNOR curated interactions for CHTOP Gene
Transcripts for CHTOP Gene
mRNA/cDNA for CHTOP Gene
- (5) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (395) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHTOP Gene
- Chromatin target of PRMT1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CHTOP
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHTOP
- GenScript: Design CRISPR guide RNA sequences for CHTOP
miRNA Products
- Search ViGene Biosciences for CHTOP
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHTOP
- Browse OriGene Inhibitory RNA Products For CHTOP
-
ViGene Biosciences ready-to-package AAV shRNAs for CHTOP gene
Clone Products
- Sino Biological Human cDNA Clone for CHTOP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHTOP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHTOP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
Expression for CHTOP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (10.0) and Testis (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHTOP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CHTOP Gene:
CHTOPSOURCE GeneReport for Unigene cluster for CHTOP Gene:
Hs.611057mRNA Expression by UniProt/SwissProt for CHTOP Gene:
Q9Y3Y2-CHTOP_HUMAN
Tissue specificity:
Expressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells (PubMed:25284789).
Evidence on tissue expression from TISSUES for CHTOP Gene
- Nervous system(4.9)
- Liver(4.6)
- Lymph node(4.3)
- Eye(4.2)
- Lung(3.2)
- Pancreas(2.5)
- Kidney(2.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for CHTOP
-
OriGene qPCR primer pairs for CHTOP
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHTOP Gene
Orthologs for CHTOP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHTOP 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Chtop 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CHTOP 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CHTOP 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CHTOP 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHTOP 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CHTOP 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6026 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52883 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | chtopa 35 |
|
OneToMany | |
| chtopb 35 |
|
OneToMany | |||
| wufb17a05 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6891 35 |
|
OneToOne |
- Species where no ortholog for CHTOP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CHTOP Gene
No data available for Paralogs for CHTOP Gene
Variants for CHTOP Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000187941 | -- | 153,639,525(+) | CCACC(C/T)TGAAC | intron-variant | |
| rs1000426770 | -- | 153,638,570(+) | CTTCT(A/C)TGGAA | intron-variant | |
| rs1000651580 | -- | 153,642,565(+) | TATTT(G/T)TAATA | intron-variant | |
| rs1000690592 | -- | 153,642,959(+) | AGGCA(C/T)CTATC | intron-variant | |
| rs1000851877 | -- | 153,637,704(+) | TCGAC(C/T)ACTGA | intron-variant |
Residual Variation Intolerance Score:
52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.85;
34.68% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CHTOP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CHTOP
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHTOP Gene
Disorders for CHTOP Gene
Relevant External Links for CHTOP
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CHTOP
No disorders were found for CHTOP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHTOP Gene
Publications for CHTOP Gene
- Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation. (PMID: 19254951) Zullo A.J. … Grusby M.J. (J. Biol. Chem. 2009) 2 3 4 64
- 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. (PMID: 25284789) Takai H. … Akiyama T. (Cell Rep 2014) 3 4 64
- Chtop is a component of the dynamic TREX mRNA export complex. (PMID: 23299939) Chang C.T. … Wilson S.A. (EMBO J. 2013) 3 4 64
- Mapping interactions between mRNA export factors in living cells. (PMID: 23826332) Teng I.F. … Wilson S.A. (PLoS ONE 2013) 3 4 64
- Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. (PMID: 19858291) van Dijk T.B. … Philipsen S. (Mol. Cell. Biol. 2010) 3 4 64
Products for CHTOP Gene
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- antibodies-online Antibodies for CHTOP: See all 35
- antibodies-online Kits for CHTOP: See all 4
- antibodies-online Proteins for CHTOP: See all 5
- Search antibodies-online for peptides
- GeneTex CHTOP antibody for CHTOP
- Search GeneTex for Proteins for CHTOP
- ViGene Biosciences adenoviral particle packaged cDNA for CHTOP gene
- ViGene Biosciences lentiviral particle packaged cDNA for CHTOP gene
- ViGene Biosciences ready-to-package AAV shRNAs for CHTOP gene
- Search ViGene Biosciences for CHTOP
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHTOP
- VectorBuilder custom plasmid, inducible vectors for CHTOP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHTOP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CHTOP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer