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CHTOP Gene

protein-coding   GIFtS: 45
GCID: GC01P153607

Chromatin Target Of PRMT1

(Previous name: chromosome 1 open reading frame 77)
(Previous symbol: C1orf77)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromatin Target Of PRMT11 2     FL-SRAG2
C1orf771 2 3     SRAG-32
FOP2 3 5     SRAG-52
SRAG2 3 5     Chromatin Target Of PRMT1 Protein2
Small Protein Rich In Arginine And Glycine1 2     pp77042
Friend Of PRMT1 Protein2 3     Small Arginine- And Glycine-Rich Protein3
Chromosome 1 Open Reading Frame 771     C10orf775
Friend Of Prmt11     

External Ids:    HGNC: 245111   Entrez Gene: 260972   Ensembl: ENSG000001606797   OMIM: 6142065   UniProtKB: Q9Y3Y23   

Export aliases for CHTOP gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHTOP Gene:
This gene encodes a small nuclear protein that is characterized by a arginine and glycine rich region. The encoded
protein may be involved in cell cycle progression. This protein interacts with protein arginine
methyltransferases and plays a role in the activation of estradiol-dependent transcription. Alternate splicing
results in multiple transcript variants. (provided by RefSeq, Sep 2011)

GeneCards Summary for CHTOP Gene:
CHTOP (chromatin target of PRMT1) is a protein-coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: CHTOP_HUMAN, Q9Y3Y2
Function: Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a
role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of
ZNF148 and subsequent transactivation of ZNF148 target genes
Function: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to
couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not
with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to
mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a
region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.
The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs
and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with
ALYREF/THOC4 enhances NXF1 RNA binding activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CHTOP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHTOP promoter sequence
   Search Chromatin IP Primers for CHTOP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHTOP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

CHTOP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHTOP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153607:  view genomic region     (about GC identifiers)

Start:
153,606,458 bp from pter      End:
153,618,782 bp from pter
Size:
12,325 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CHTOP_HUMAN, Q9Y3Y2 (See protein sequence)
Recommended Name: Chromatin target of PRMT1 protein  
Size: 248 amino acids; 26397 Da
Subunit: Interacts with PRMT1 and PRMT5. Interacts with the 5FMC complex; the interaction is
methylation-dependent. Interacts with FYTTD1, SET and PRC1 complex members CBX4, RNF2 and PHC2; the interactions
are methylation-independent. Interacts with ZNF148. Component of the transcription/export (TREX) complex at least
composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure
involving ATP-dependent remodeling; in the complex interacts (methylated) with ALYREF/THOC4 and with DDX39B in a
methylation-independent manner. Interacts (methylated) with NXF1; the interaction is mutually exclusive with the
NXF1:THOC5 interaction
Sequence caution: Sequence=AAH02733.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH70027.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAL55869.1;
Type=Frameshift; Positions=181;
Secondary accessions: D3DV55 Q0VAQ8 Q2VPI9 Q5T7Y8 Q5T7Y9 Q5T7Z0 Q6NSM4 Q6PB28 Q8WYT9 Q9BUC5
Q9H034 Q9H2L0
Alternative splicing: 3 isoforms:  Q9Y3Y2-1   Q9Y3Y2-3   Q9Y3Y2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHTOP: NX_Q9Y3Y2

Explore proteomics data for CHTOP at MOPED

Post-translational modifications: 

  • Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5 (By similarity)1
  • Ubiquitination2 at Lys16, Lys81, Lys226
  • Modification sites at PhosphoSitePlus

  • See CHTOP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193541.1  NP_001231593.1  NP_056422.2  

    ENSEMBL proteins: 
     ENSP00000357683   ENSP00000385228   ENSP00000357676   ENSP00000357675   ENSP00000357679  

    CHTOP Human Recombinant Protein Products:

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    OriGene Purified Protein for CHTOP
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    OriGene MassSpec for CHTOP
    OriGene Custom Protein Services for CHTOP
    GenScript Custom Purified and Recombinant Proteins Services for CHTOP
    Novus Biologicals CHTOP Protein
    Novus Biologicals CHTOP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CHTOP 

     
    antibodies-online proteins for CHTOP (3 products) 

     
    antibodies-online peptides for CHTOP

    CHTOP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CHTOP Antibody
    Abcam antibodies for CHTOP
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CHTOP
    antibodies-online antibodies for CHTOP (29 products) 

    CHTOP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHTOP
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CHTOP 
    antibodies-online kits for CHTOP (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR025715 FoP_duplication

    Graphical View of Domain Structure for InterPro Entry Q9Y3Y2

    ProtoNet protein and cluster: Q9Y3Y2


    Find genes that share domains with CHTOP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHTOP_HUMAN, Q9Y3Y2
    Function: Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a
    role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of
    ZNF148 and subsequent transactivation of ZNF148 target genes
    Function: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to
    couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not
    with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to
    mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a
    region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.
    The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs
    and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with
    ALYREF/THOC4 enhances NXF1 RNA binding activity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI19858291
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CHTOP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CHTOP:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Chtop):
     mortality/aging 

    Find genes that share phenotypes with CHTOP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CHTOP

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHTOP:
    hsa-mir-155-5p (MIRT020760), hsa-mir-193b-3p (MIRT041594), hsa-mir-296-3p (MIRT038414), hsa-mir-197-3p (MIRT048090), hsa-mir-186-5p (MIRT045224), hsa-mir-92a-3p (MIRT049707)

    Block miRNA regulation of human, mouse, rat CHTOP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHTOP (see all 20):
    hsa-miR-548j hsa-miR-576-3p hsa-miR-300 hsa-miR-548i hsa-miR-485-3p hsa-miR-181a-2* hsa-miR-144 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCHTOP 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CHTOP
    Predesigned siRNA for gene silencing in human, mouse, rat CHTOP

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CHTOP (see all 8)
    OriGene ORF clones in mouse, rat for CHTOP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CHTOP (NM_015607)
    Sino Biological Human cDNA Clone for CHTOP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHTOP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHTOP

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHTOP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHTOP_HUMAN, Q9Y3Y2: Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm (By similarity). Nucleus speckle.
    Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear
    speckles known as perispeckles in which TREX complex assembly seems to occur

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000346transcription export complex IDA--
    GO:0005634nucleus ----
    GO:0005730nucleolus IEA--
    GO:0016607nuclear speck IDA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with CHTOP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHTOP
    Interactions:

        Search GeneGlobe Interaction Network for CHTOP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for CHTOP (Q9Y3Y21, 3 ENSP000003576834) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT1Q998731, 3EBI-347794,EBI-78738 I2D: score=1 
    DDX39BQ138383I2D: score=1 
    ENSG00000215425Q138383I2D: score=1 
    ENSG00000225073Q138383I2D: score=1 
    ENSG00000225859Q138383I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006406mRNA export from nucleus IDA--
    GO:0032781positive regulation of ATPase activity IDA--
    GO:0051096positive regulation of helicase activity IDA--

    Find genes that share ontologies with CHTOP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHTOP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHTOP gene (3 alternative transcripts): 
    NM_001206612.1  NM_001244664.1  NM_015607.3  

    Unigene Cluster for CHTOP:

    Chromatin target of PRMT1
    Hs.611057  [show with all ESTs]
    Unigene Representative Sequence: NM_001206612
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368694(uc009woi.2 uc001fcn.2 uc001fcm.2 uc021ozz.1)
    ENST00000495554(uc001fco.2) ENST00000403433 ENST00000368687 ENST00000368686(uc009woj.2)
    ENST00000368690
    miRNA
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    Block miRNA regulation of human, mouse, rat CHTOP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHTOP (see all 20):
    hsa-miR-548j hsa-miR-576-3p hsa-miR-300 hsa-miR-548i hsa-miR-485-3p hsa-miR-181a-2* hsa-miR-144 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCHTOP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHTOP
    Predesigned siRNA for gene silencing in human, mouse, rat CHTOP
    Clone
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    OriGene clones in human, mouse for CHTOP (see all 8)
    OriGene ORF clones in mouse, rat for CHTOP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CHTOP (NM_015607)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHTOP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHTOP
    Primer
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    OriGene qPCR primer pairs and template standards for CHTOP
    OriGene qSTAR qPCR primer pairs in human, mouse for CHTOP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHTOP
      QuantiTect SYBR Green Assays in human, mouse, rat CHTOP
      QuantiFast Probe-based Assays in human, mouse, rat CHTOP

    Additional mRNA sequence: 

    AF261137.1 AF318362.1 AK308713.1 AL512704.1 BC002733.2 BC059949.1 BC108721.1 BC120961.1 
    BC120962.1 

    Selected DOTS entries (see all 28):

    DT.92448317  DT.99960355  DT.95347023  DT.452791  DT.100885866  DT.92448309  DT.121412370  DT.97859775 
    DT.40121223  DT.121412415  DT.86846433  DT.92448312  DT.100728397  DT.95347096  DT.100035411  DT.100038537 
    DT.121412414  DT.100038535  DT.100885873  DT.121412382  DT.97859777  DT.100038532  DT.100885869  DT.121412429 

    Selected AceView cDNA sequences (see all 395):

    BE018618 CB139028 BM692225 AL512704 CB162795 AA552427 CB138982 BQ053708 
    CB137812 BP375397 BF971221 CR612307 BU542465 CB137119 CB146732 BE502022 
    AI815533 CB857581 BM835521 AW006328 BG481222 BQ684972 CB139912 AI097479 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHTOP (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                          -     -     -           -                       -                                                   
    SP2:                          -     -     -           -                       -                                                   
    SP3:                          -     -     -           -     -     -     -     -     -     -                                       
    SP4:                          -     -     -                                                                                       
    SP5:                                                  -                       -                                                   


    ECgene alternative splicing isoforms for CHTOP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHTOP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGACTCTT
    CHTOP Expression
    About this image


    CHTOP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Ovary (Reproductive System)
    CHTOP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHTOP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.611057

    UniProtKB/Swiss-Prot: CHTOP_HUMAN, Q9Y3Y2
    Tissue specificity: Expressed in an erythroid progenitor cell line derived from peripheral blood

        Custom PCR Arrays for CHTOP
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    QuantiFast Probe-based Assays in human, mouse, rat CHTOP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHTOP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CHTOP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chtop5 RIKEN cDNA 2500003M10 gene   --   3 (39.24 cM) 90498956 
    chicken
    (Gallus gallus)
    Aves CHTOP6
    chromatin target of PRMT1
    89(a)
    1 ↔ 1
    25(702003-708798)
    lizard
    (Anolis carolinensis)
    Reptilia CHTOP6
    chromatin target of PRMT1
    90(a)
    1 ↔ 1
    GL344732.1(9144-22166)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528832 hypothetical protein MGC52883 80.04(n)    AB018189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb17a052 wufb17a05 76.99(n)   321491  BC045295.1 


    ENSEMBL Gene Tree for CHTOP (if available)
    TreeFam Gene Tree for CHTOP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHTOP (see all 339)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs353570721,2
    C--153608885(+) AAAAAA/-AAAAA 3 -- int11Minor allele frequency- -:0.00NA 2
    rs678796781,2
    C,F--153611359(+) TTTTC-/T/TT  
            
    TTTTT
    3 -- int12NA CSA 4
    rs113538191,2
    C,F--153618838(+) TGATG-/TTTTTT 3 -- ds50013Minor allele frequency- T:0.33NA CSA 6
    rs38186321,2
    C,F,A,H--160105988(-) GACATT/CGGATG 3 -- us2k123Minor allele frequency- C:0.38NS EA WA NA CSA 2350
    rs1916425921,2
    --160106017(+) GAAGTC/GGGTGG 3 -- us2k10--------
    rs730099981,2
    C,F--160106027(+) GAGACG/ATGAAG 3 -- us2k11Minor allele frequency- A:0.50WA 2
    rs287096121,2
    C--160106111(+) CTACTT/CGAGGA 3 -- us2k12Minor allele frequency- C:0.00NA 4
    rs1831583091,2
    --160106165(+) AAGTCA/GAGGAG 3 -- us2k10--------
    rs1403221371,2
    --160106210(+) AATAAA/TCTTTT 3 -- us2k10--------
    rs348231831,2
    C--160106212(+) TTTTGT/-GAGAC 3 -- us2k11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for CHTOP (153606458 - 153618782 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CHTOP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHTOP
    DNA2.0 Custom Variant and Variant Library Synthesis for CHTOP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614206    OMIM disorders: --


    Find genes that share disorders with CHTOP           About GenesLikeMe


    Export disorders for CHTOP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHTOP gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CHTOP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation. (PubMed id 19254951)1, 2, 3 Zullo A.J.... Grusby M.J. (J. Biol. Chem. 2009)
    2. Chtop is a component of the dynamic TREX mRNA export complex. (PubMed id 23299939)1, 2 Chang C.T....Wilson S.A. (EMBO J. 2013)
    3. Mapping interactions between mRNA export factors in living cells. (PubMed id 23826332)1, 2 Teng I.F. and Wilson S.A. (PLoS ONE 2013)
    4. Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. (PubMed id 19858291)1, 2 van Dijk T.B.... Philipsen S. (Mol. Cell. Biol. 2010)
    5. Fetal globin expression is regulated by Friend of Prmt1. (PubMed id 20688955)1, 2 van Dijk T.B.... Philipsen S. (Blood 2010)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26097 HGNC: 24511 AceView: DKFZP547E1010 Ensembl:ENSG00000160679 euGenes: HUgn26097
    ECgene: CHTOP H-InvDB: CHTOP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHTOP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHTOP gene:
    Search GeneIP for patents involving CHTOP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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