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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHTF8 Gene

protein-coding   GIFtS: 44
GCID: GC16M069151

CTF8, Chromosome Transmission Fidelity Factor 8 Homolog...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CTF8, Chromosome Transmission Fidelity Factor 8 Homolog (S.
Cerevisiae)1 2
Decreased Expression In Renal And Prostate Cancer Protein2 3
CTF82 3
DERPC2 3
Chromosome Transmission Fidelity Protein 8 Homolog2
hCTF83

External Ids:    HGNC: 243531   Entrez Gene: 549212   Ensembl: ENSG000001688027   OMIM: 6132025   UniProtKB: P0CG123   
UniProtKB: P0CG133   
ORGUL members:         
NONCODE14:n409100      

Export aliases for CHTF8 gene to outside databases

Previous GC identifers: GC16M067714 GC16M055024


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHTF8 Gene:
This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in
both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load
the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This
gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors.
Alternatively spliced transcript variants have been described. This gene has a pseudogene on chromosome X.
(provided by RefSeq, Jan 2010)

GeneCards Summary for CHTF8 Gene: 
CHTF8 (CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CHTF8 include prostatitis, and prostate cancer. GO annotations related to this gene include DNA binding.

UniProtKB/Swiss-Prot: CTF8_HUMAN, P0CG13
Function: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome
transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C
(CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to
single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA,
replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the
ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is
suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with
replication fork progression

Gene Wiki entry for CHTF8 (CTF8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHTF8 gene promoter:
         AREB6   HEN1   HNF-1   Pax-4a   HNF-1A   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CHTF8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHTF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CHTF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHTF8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M069151:  view genomic region     (about GC identifiers)

Start:
69,151,912 bp from pter      End:
69,166,493 bp from pter
Size:
14,582 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CTF8A_HUMAN, P0CG12 (See protein sequence)
Recommended Name: Chromosome transmission fidelity protein 8 homolog isoform 2  
Size: 524 amino acids; 51391 Da
Subcellular location: Nucleus
Miscellaneous: Found in a common chromosomal region of deletion in breast cancer
Caution: mRNA expression studied by PubMed:12477976 does not differentiate between isoform 1 and isoform 2
Sequence caution: Sequence=CAD38758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8MYX8 Q71E72 Q8NDH8 Q8WV66 Q9NX73
Alternative splicing: 2 isoforms:  P0CG12-1   P0CG13-1   

UniProtKB/Swiss-Prot: CTF8_HUMAN, P0CG13 (See protein sequence)

Recommended Name: Chromosome transmission fidelity protein 8 homolog  
Size: 121 amino acids; 13314 Da
Subunit: Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The
CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex interacts with POLH.
CTF18/CTF8/DCC1 associate with PCNA. CTF8 exists as a dimer with DCC1
Subcellular location: Nucleus. Note=Associates with chromatin during S phase
Caution: mRNA expression studied by PubMed:12477976 does not differentiate between isoform 1 and isoform 2
Sequence caution: Sequence=AAQ08897.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAA91144.1;
Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=EAW83250.1; Type=Erroneous translation; Note=Wrong
choice of CDS;
Secondary accessions: A8MYX8 Q71E72 Q8NDH8 Q8WV66 Q9NX73
Alternative splicing: 2 isoforms:  P0CG13-1   P0CG12-1   

Explore the universe of human proteins at neXtProt for CHTF8: NX_P0CG13

Explore proteomics data for CHTF8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus (DERPC)
  • View neXtProt modification sites for NX_P0CG13

  • CHTF8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHTF8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001034779.1  NP_001035236.1  

    ENSEMBL proteins: 
     ENSP00000408367   ENSP00000430899   ENSP00000430079   ENSP00000462519   ENSP00000381290  
     ENSP00000427718   ENSP00000455402   ENSP00000428130   ENSP00000427728   ENSP00000455699  
     ENSP00000305687  

    Human Recombinant Protein Products for CHTF8: 
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    Cloud-Clone Corp. Proteins for CHTF8 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CHTF8 for ontologies           About GeneDecksing



    CHTF8 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR018607 Chromosome_trans_fidel_Ctf8

    Graphical View of Domain Structure for InterPro Entry P0CG12
    Graphical View of Domain Structure for InterPro Entry P0CG13

    ProtoNet protein and cluster: P0CG12

    UniProtKB/Swiss-Prot: CTF8A_HUMAN, P0CG12
    Similarity: Belongs to the DERPC family

    UniProtKB/Swiss-Prot: CTF8_HUMAN, P0CG13
    Similarity: Belongs to the CTF8 family


    CHTF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTF8A_HUMAN, P0CG12
    Function: Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed

         UniProtKB/Swiss-Prot: CTF8_HUMAN, P0CG13
    Function: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome
    transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C
    (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to
    single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA,
    replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the
    ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is
    suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with
    replication fork progression

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    CHTF8 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHTF8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gastric cancer network 2
    Gastric cancer network 2


    1 BioSystems Pathway for CHTF8
        Gastric cancer network 2


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHTF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for CHTF8 (P0CG133 ENSP000003812904) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DSCC1ENSP000003221804STRING: ENSP00000322180
    CHTF18ENSP000002623154STRING: ENSP00000262315
    PCNAENSP000003684384STRING: ENSP00000368438
    RFC2ENSP000000550774STRING: ENSP00000055077
    RFC3ENSP000003694114STRING: ENSP00000369411
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0007049cell cycle IEA--

    CHTF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHTF8 (CTF8)

    Search CenterWatch for drugs/clinical trials and news about CHTF8 / CTF8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHTF8 gene (6 alternative transcripts): 
    NM_001039690.3  NM_001040146.3  NM_001002847.1  NM_001040144.1  NM_001040145.1  NM_017804.3  

    Unigene Cluster for CHTF8:

    CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
    Hs.85962  [show with all ESTs]
    Unigene Representative Sequence: AF525164
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448552 ENST00000523421 ENST00000518041 ENST00000519534 ENST00000398235
    ENST00000519520 ENST00000567763 ENST00000522497 ENST00000520529 ENST00000522091
    ENST00000306585(uc002ewn.2 uc002ewp.2 uc002ewo.2)
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    hsa-miR-124* hsa-miR-1321 hsa-miR-4254 hsa-miR-328 hsa-miR-642a hsa-miR-188-5p hsa-miR-128 hsa-miR-650
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    Additional mRNA sequence: 

    AF525164.1 AK000407.1 AL833902.1 BC018700.2 BC069059.1 NR_033227.1 

    22 DOTS entries:

    DT.95195379  DT.80100606  DT.100822682  DT.100839004  DT.100822686  DT.100822689  DT.100773720  DT.120681234 
    DT.101983767  DT.95366397  DT.95366401  DT.100822684  DT.100838774  DT.120681042  DT.100822680  DT.100822681 
    DT.100822683  DT.102831935  DT.120681190  DT.75125276  DT.92039675  DT.95366396 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CHTF8 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
    SP1:        -     -                 -                                       
    SP2:                                -                                       
    SP3:        -     -                                                         
    SP4:        -     -           -     -                                       
    SP5:        -     -     -           -                                       


    ECgene alternative splicing isoforms for CHTF8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHTF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCCGTAGC
    CHTF8 Expression
    About this image


    See CHTF8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHTF8

    SOURCE GeneReport for Unigene cluster: Hs.85962

    UniProtKB/Swiss-Prot: CTF8A_HUMAN, P0CG12
    Tissue specificity: Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver,
    ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate
    tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules

    UniProtKB/Swiss-Prot: CTF8_HUMAN, P0CG13
    Tissue specificity: Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver,
    ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate
    tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHTF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHTF8 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chtf81 , 5 CTF8, chromosome transmission fidelity factor 8 homolog more5
    CTF8, chromosome transmission fidelity factor 81
    94.77(n)1
    91.74(a)1
      8 (53.30 cM)5
    2149871  NM_145412.31  NP_663387.31 
     1068838635 
    chicken
    (Gallus gallus)
    Aves CHTF81 CTF8, chromosome transmission fidelity factor 8 homolog more 69.35(n)
    74.11(a)
      769609  XM_003641948.1  XP_003641996.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHTF86
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343914.1(9921-11890)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.105692 Xenopus laevis transcribed sequence with weak similarity more 75.34(n)    BI443665.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.242402 Transcribed sequence with weak similarity to protein more 75.25(n)    BM861379.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG340011 CG34001 50.71(n)
    44.44(a)
      3885640  NM_001038910.2  NP_001033999.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T22C1.46
    Protein T22C1.4
    28(a)
    1 ↔ 1
    I(7940132-7940757)


    ENSEMBL Gene Tree for CHTF8 (if available)
    TreeFam Gene Tree for CHTF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHTF8 gene

    CHTF8 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CHTF8
    PGOHUM00000241728 PGOHUM00000241729


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/245 SNPs in CHTF8 are shown (see all 245)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1435612961,2
    C,F--69153143(+) AATGGT/GTGGAT 3 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.01EU 569
    rs790512701,2
    C,F--69153251(+) AAAGGG/TATTGG 3 -- ut31 nc-transcript-variant3Minor allele frequency- T:0.04NA EA EU 813
    rs1815322941,2
    --69153567(+) AAGAGA/GCCACC 3 -- ut31 nc-transcript-variant0--------
    rs37436801,2
    C,F,H--69153608(+) CAGGCC/TACTTG 3 -- ut31 nc-transcript-variantese39Minor allele frequency- T:0.03NS EA NA 980
    rs1181722921,2
    C,F--69153669(+) GCAGGG/ATTTGT 3 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.03NA 120
    rs1858662451,2
    --69153701(+) ATTGGC/GGTTTG 3 -- ut31 nc-transcript-variant0--------
    rs1480242171,2
    C--69153770(+) AACACC/TGGCTC 3 -- ut31 nc-transcript-variant0--------
    rs1407940191,2
    C--69153797(+) TCCAGA/GGCCCA 3 -- ut31 nc-transcript-variant0--------
    rs340196751,2
    C,F,H--69153940(+) TCCTAA/GGGTTT 3 -- ut31 nc-transcript-variant4Minor allele frequency- G:0.03NS NA 232
    rs1501079741,2
    C--69154101(+) AATGAA/GCCTGA 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for CHTF8 (69151912 - 69166493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CHTF8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1850CNV Loss18451855
    nsv906819CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613202    OMIM disorders: --

    6 diseases for CHTF8:    About MalaCards
    prostatitis    prostate cancer    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    gastric cancer    breast cancer


    CHTF8 for disorders           About GeneDecksing


    Export disorders for CHTF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHTF8 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CHTF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. (PubMed id 12766176)1, 2, 3 Merkle C.J.... Chen J. (2003)
    2. A second proliferating cell nuclear antigen loader complex, Ctf18- replication factor C, stimulates DNA polymerase eta activity. (PubMed id 17545166)1, 2 Shiomi Y.... Tsurimoto T. (2007)
    3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. (PubMed id 12930902)1, 2 Bermudez V.P....Hurwitz J. (2003)
    7. A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors. (PubMed id 12477976)1, 2 Sun M....Zou Z. (2002)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Stable interaction between the human proliferating ce ll nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA poly merase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, an d Ctf8. (PubMed id 20826785)1 Murakami T....Tsurimoto T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54921 HGNC: 24353 Ensembl:ENSG00000168802 euGenes: HUgn54921 ECgene: CHTF8
    H-InvDB: CHTF8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHTF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHTF8 gene:
    Search GeneIP for patents involving CHTF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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