Aliases for CHTF8 Gene
Aliases for CHTF8 Gene
- Chromosome Transmission Fidelity Factor 8 2 3 5
- Decreased Expression In Renal And Prostate Cancer Protein 3 4
- DERPC 3 4
- CTF8 3 4
- CTF8, Chromosome Transmission Fidelity Factor 8 Homolog (S. Cerevisiae) 2
- CTF8, Chromosome Transmission Fidelity Factor 8 Homolog 3
- Chromosome Transmission Fidelity Protein 8 Homolog 3
- HCTF8 4
External Ids for CHTF8 Gene
Previous GeneCards Identifiers for CHTF8 Gene
- GC16M067714
- GC16M055024
Summaries for CHTF8 Gene
-
This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternatively spliced transcript variants have been described. This gene has a pseudogene on chromosome X. [provided by RefSeq, Jan 2010]
GeneCards Summary for CHTF8 Gene
CHTF8 (Chromosome Transmission Fidelity Factor 8) is a Protein Coding gene. Among its related pathways are Gastric Cancer Network 2.
UniProtKB/Swiss-Prot for CHTF8 Gene
-
Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.
-
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHTF8 Gene
Genomics for CHTF8 Gene
Regulatory Elements for CHTF8 Gene
- Transcription factor binding sites by QIAGEN in the CHTF8 gene promoter:
Regulatory Element Products
Genomic Location for CHTF8 Gene
- Chromosome:
- 16
- Start:
- 69,118,009 bp from pter
- End:
- 69,132,590 bp from pter
- Size:
- 14,582 bases
- Orientation:
- Minus strand
Genomic View for CHTF8 Gene
- Cytogenetic band:
-
- 16q22.1 by Ensembl
- 16q22.1 by Entrez Gene
- 16q22.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHTF8 Gene
Proteins for CHTF8 Gene
-
Protein details for CHTF8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0CG12-CTF8A_HUMAN
- Recommended name:
- Chromosome transmission fidelity protein 8 homolog isoform 2
- Protein Accession:
- P0CG12
- A8MYX8
- Q71E72
- Q8NDH8
- Q8WV66
- Q9NX73
Protein attributes for CHTF8 Gene
- Size:
- 524 amino acids
- Molecular mass:
- 51391 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Found in a common chromosomal region of deletion in breast cancer.
- SequenceCaution:
-
- Sequence=CAD38758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
-
Protein details for CHTF8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0CG13-CTF8_HUMAN
- Recommended name:
- Chromosome transmission fidelity protein 8 homolog
- Protein Accession:
- P0CG13
- A8MYX8
- Q71E72
- Q8NDH8
- Q8WV66
- Q9NX73
Protein attributes for CHTF8 Gene
- Size:
- 121 amino acids
- Molecular mass:
- 13314 Da
- Quaternary structure:
-
- Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex interacts with POLH. CTF18/CTF8/DCC1 associate with PCNA. CTF8 exists as a dimer with DCC1.
- SequenceCaution:
-
- Sequence=AAQ08897.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAA91144.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW83250.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Protein Expression for CHTF8 Gene
Post-translational modifications for CHTF8 Gene
Other Protein References for CHTF8 Gene
Antibody Products
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Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CHTF8
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- antibodies-online Proteins for CHTF8: See all 4
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Assay Products
No data available for DME Specific Peptides for CHTF8 Gene
Domains & Families for CHTF8 Gene
Suggested Antigen Peptide Sequences for CHTF8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P0CG12- Family:
-
- Belongs to the DERPC family.
- Belongs to the CTF8 family.
No data available for Gene Families for CHTF8 Gene
Function for CHTF8 Gene
Molecular function for CHTF8 Gene
- UniProtKB/Swiss-Prot Function:
- Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.
- UniProtKB/Swiss-Prot Function:
- Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003689 | DNA clamp loader activity | IDA | -- |
| GO:0043142 | single-stranded DNA-dependent ATPase activity | IDA | -- |
Phenotypes for CHTF8 Gene
- GenomeRNAi human phenotypes for CHTF8:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHTF8 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for CHTF8
-
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miRNA for CHTF8 Gene
- miRTarBase miRNAs that target CHTF8
-
- hsa-mir-296-3p (MIRT038507)
- hsa-mir-106a-5p (MIRT048338)
- hsa-mir-17-5p (MIRT050932)
- hsa-mir-432-3p (MIRT479233)
- hsa-mir-6869-5p (MIRT479234)
- hsa-mir-4709-3p (MIRT479235)
- hsa-mir-1255b-5p (MIRT479236)
- hsa-mir-1255a (MIRT479237)
- hsa-mir-6744-5p (MIRT479238)
- hsa-mir-571 (MIRT479239)
- hsa-mir-1911-5p (MIRT479240)
- hsa-mir-423-5p (MIRT479241)
- hsa-mir-3184-5p (MIRT479242)
- hsa-mir-6133 (MIRT479243)
- hsa-mir-6130 (MIRT479244)
- hsa-mir-6129 (MIRT479245)
- hsa-mir-6127 (MIRT479246)
- hsa-mir-4510 (MIRT479247)
- hsa-mir-4419a (MIRT479248)
- hsa-mir-3922-3p (MIRT479249)
- hsa-mir-3176 (MIRT479250)
- hsa-mir-3190-5p (MIRT479251)
- hsa-mir-3126-3p (MIRT479252)
- hsa-mir-6873-5p (MIRT479253)
- hsa-mir-624-5p (MIRT479254)
miRNA Products
- Search ViGene Biosciences for CHTF8
Inhibitory RNA Products
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-
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Clone Products
- Sino Biological Human cDNA Clone for CHTF8
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- VectorBuilder custom plasmid, inducible vectors for CHTF8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHTF8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CHTF8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CHTF8 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHTF8 Gene
Localization for CHTF8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHTF8 Gene
- Nucleus.
- Nucleus. Note=Associates with chromatin during S phase.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0031390 | Ctf18 RFC-like complex | IEA,IBA | -- |
| GO:0070062 | extracellular exosome | IDA | 23533145 |
Pathways & Interactions for CHTF8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gastric Cancer Network 2 | ||
Pathways by source for CHTF8 Gene
1 BioSystems pathway for CHTF8 Gene
Interacting Proteins for CHTF8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006260 | DNA replication | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007064 | mitotic sister chromatid cohesion | IEA,IBA | -- |
| GO:1900264 | positive regulation of DNA-directed DNA polymerase activity | IDA | -- |
No data available for SIGNOR curated interactions for CHTF8 Gene
Transcripts for CHTF8 Gene
mRNA/cDNA for CHTF8 Gene
- (9) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHTF8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHTF8
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHTF8
- GenScript: Design CRISPR guide RNA sequences for CHTF8
miRNA Products
- Search ViGene Biosciences for CHTF8
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CHTF8
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-
ViGene Biosciences ready-to-package AAV shRNAs for CHTF8 gene
Clone Products
- Sino Biological Human cDNA Clone for CHTF8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHTF8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHTF8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||
| SP7: | - | - | - | - | - |
Expression for CHTF8 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHTF8 Gene
NURSA nuclear receptor signaling pathways regulating expression of CHTF8 Gene:
CHTF8SOURCE GeneReport for Unigene cluster for CHTF8 Gene:
Hs.85962mRNA Expression by UniProt/SwissProt for CHTF8 Gene:
P0CG12-CTF8A_HUMANEvidence on tissue expression from TISSUES for CHTF8 Gene
- Nervous system(3.4)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CHTF8
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHTF8 Gene
Orthologs for CHTF8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHTF8 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CHTF8 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chtf8 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CHTF8 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Chtf8 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CHTF8 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHTF8 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CHTF8 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | chtf8 34 |
|
||
| Str.4395 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10569 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | chtf8 34 35 |
|
||
| Dr.24240 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2759 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012170 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG34001 34 35 |
|
- Species where no ortholog for CHTF8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CHTF8 Gene
Pseudogenes.org Pseudogenes for CHTF8 Gene
No data available for Paralogs for CHTF8 Gene
Variants for CHTF8 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000311617 | -- | 69,119,977(+) | GTCCT(A/G)GGAGA | intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime | |
| rs1000537458 | -- | 69,130,925(+) | GGTAA(C/T)TTCTC | intron-variant, upstream-variant-2KB | |
| rs1000769290 | -- | 69,130,528(+) | ACAGA(A/C)CTGGA | intron-variant | |
| rs1000915406 | -- | 69,134,408(+) | GACCA(C/G)TGGGA | intron-variant, upstream-variant-2KB | |
| rs1001210112 | -- | 69,122,032(+) | TCACC(A/C)GCCTC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1070354 | CNV | deletion | 25765185 |
| nsv1850 | CNV | deletion | 18451855 |
Relevant External Links for CHTF8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CHTF8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHTF8 Gene
Disorders for CHTF8 Gene
Relevant External Links for CHTF8
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CHTF8
No disorders were found for CHTF8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHTF8 Gene
Publications for CHTF8 Gene
- Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. (PMID: 12766176) Merkle C.J. … Chen J. (J. Biol. Chem. 2003) 2 3 4 64
- A second proliferating cell nuclear antigen loader complex, Ctf18- replication factor C, stimulates DNA polymerase eta activity. (PMID: 17545166) Shiomi Y. … Tsurimoto T. (J. Biol. Chem. 2007) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
Products for CHTF8 Gene
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- Novus Biologicals Antibodies for CHTF8
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- Cyagen custom Knockout/knockin (KOKI) mouse models for CHTF8
- VectorBuilder custom plasmid, inducible vectors for CHTF8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHTF8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CHTF8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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