Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHTF18 Gene

Aliases for CHTF18 Gene

  • Chromosome Transmission Fidelity Factor 18 2 3 5
  • C16orf41 3 4
  • Ctf18 3 4
  • CHL12 3 4
  • CTF18, Chromosome Transmission Fidelity Factor 18 Homolog (S. Cerevisiae) 2
  • Some Homology With Holliday Junction DNA Helicase RUVB Like 3
  • CTF18, Chromosome Transmission Fidelity Factor 18 Homolog 3
  • Chromosome Transmission Fidelity Protein 18 Homolog 3
  • Chromosome 16 Open Reading Frame 41 2
  • C321D2.3 (Novel Protein) 3
  • C321D2.4 (Novel Protein) 3
  • Homolog Of Yeast CHL12 3
  • C321D2.2 3
  • C321D2.3 3
  • C321D2.4 3
  • EC 3.6.1 58
  • HCTF18 4
  • RUVBL 3

External Ids for CHTF18 Gene

Previous HGNC Symbols for CHTF18 Gene

  • C16orf41

Previous GeneCards Identifiers for CHTF18 Gene

  • GC16P000859
  • GC16P000778
  • GC16P000838
  • GC16P000762
  • GC16P000815
  • GC16P000861
  • GC16P000886
  • GC16P000904
  • GC16P000918
  • GC16P000939

Summaries for CHTF18 Gene

Entrez Gene Summary for CHTF18 Gene

  • This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016]

GeneCards Summary for CHTF18 Gene

CHTF18 (Chromosome Transmission Fidelity Factor 18) is a Protein Coding gene. Among its related pathways are Gastric Cancer Network 2. GO annotations related to this gene include ATPase activity and four-way junction helicase activity.

UniProtKB/Swiss-Prot for CHTF18 Gene

  • Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.

Gene Wiki entry for CHTF18 Gene

Additional gene information for CHTF18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHTF18 Gene

Genomics for CHTF18 Gene

Regulatory Elements for CHTF18 Gene

Enhancers for CHTF18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H000066 1.8 FANTOM5 ENCODE dbSUPER 23.5 -714.5 -714545 13 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF143 WASH4P WDR90 RHOT2 ENSG00000268836 LUC7L CHTF18 NPRL3 WDR24 RHBDF1 CAPN15
GH16H001308 1.4 ENCODE dbSUPER 27.5 +522.7 522709 5 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 NFYC WDR90 CRAMP1 ENSG00000261505 TELO2 UBE2I E4F1 TSC2 ENSG00000260051 JMJD8 RHOT2
GH16H001377 1.3 ENCODE dbSUPER 26.2 +590.8 590795 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 CBX5 FOS CHTF18 CCDC154 IFT140 CRAMP1 UNKL UBE2I TELO2 TSC2 E4F1 TSR3
GH16H000396 1.4 ENCODE dbSUPER 23.9 -388.2 -388163 7 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 WDR90 ENSG00000261505 WASH4P RHOT2 UBE2I NME4 WDR24 JMJD8 LUC7L CAPN15
GH16H000180 1.4 Ensembl ENCODE 22.9 -606.9 -606948 1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 ZNF143 ZNF207 DEK WDR90 WDR24 RHOT2 ENSG00000268836 WASH4P LUC7L ENSG00000269482 CHTF18 JMJD8 LMF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHTF18 on UCSC Golden Path with GeneCards custom track

Promoters for CHTF18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082249 454 1401 PKNOX1 ATF1 ARID4B SIN3A ZNF2 GLIS2 ELK1 ZNF143 ZNF207 FOS

Genomic Location for CHTF18 Gene

Chromosome:
16
Start:
788,046 bp from pter
End:
800,737 bp from pter
Size:
12,692 bases
Orientation:
Plus strand

Genomic View for CHTF18 Gene

Genes around CHTF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHTF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHTF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHTF18 Gene

Proteins for CHTF18 Gene

  • Protein details for CHTF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVB6-CTF18_HUMAN
    Recommended name:
    Chromosome transmission fidelity protein 18 homolog
    Protein Accession:
    Q8WVB6
    Secondary Accessions:
    • B7ZBA2
    • D3DU68
    • Q7Z6Y4
    • Q7Z6Y6
    • Q9BR83
    • Q9BRG5
    • Q9H7K3

    Protein attributes for CHTF18 Gene

    Size:
    975 amino acids
    Molecular mass:
    107383 Da
    Quaternary structure:
    • Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5 (PubMed:12766176, PubMed:12930902). During assembly of the CTF18-RFC complex, CTF18 may first assemble into a subcomplex with RFC2, RFC3, RFC4 and RFC5. CTF18 then interacts directly with CTF8, which in turn interacts with DCC1 (PubMed:12766176, PubMed:12930902). The CTF18-RFC complex associates with PCNA and with DNA polymerase POLH (PubMed:12766176, PubMed:17545166). The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex (PubMed:12766176). CTF18 interacts with SMC1A and RAD21 (PubMed:12930902). Interacts with DDX11 (PubMed:18499658).
    SequenceCaution:
    • Sequence=AAH06437.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15766.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHTF18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHTF18 Gene

Selected DME Specific Peptides for CHTF18 Gene

Q8WVB6:
  • GPPGLGKTT
  • PGLGKTTL

Post-translational modifications for CHTF18 Gene

  • Ubiquitination at Lys455
  • Modification sites at PhosphoSitePlus

Domains & Families for CHTF18 Gene

Gene Families for CHTF18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CHTF18 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WVB6

UniProtKB/Swiss-Prot:

CTF18_HUMAN :
  • Belongs to the activator 1 small subunits family. CTF18 subfamily.
Family:
  • Belongs to the activator 1 small subunits family. CTF18 subfamily.
genes like me logo Genes that share domains with CHTF18: view

Function for CHTF18 Gene

Molecular function for CHTF18 Gene

UniProtKB/Swiss-Prot Function:
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.

Enzyme Numbers (IUBMB) for CHTF18 Gene

Phenotypes From GWAS Catalog for CHTF18 Gene

Gene Ontology (GO) - Molecular Function for CHTF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003689 contributes_to DNA clamp loader activity IDA 12930902
GO:0005515 protein binding IPI 12930902
GO:0005524 ATP binding IEA --
GO:0043142 contributes_to single-stranded DNA-dependent ATPase activity IDA 12930902
genes like me logo Genes that share ontologies with CHTF18: view
genes like me logo Genes that share phenotypes with CHTF18: view

Animal Models for CHTF18 Gene

MGI Knock Outs for CHTF18:

Animal Model Products

CRISPR Products

miRNA for CHTF18 Gene

miRTarBase miRNAs that target CHTF18

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHTF18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHTF18 Gene

Localization for CHTF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHTF18 Gene

Nucleus. Note=Associates with chromatin during S phase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHTF18 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHTF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IDA 19946888
GO:0031390 Ctf18 RFC-like complex IDA 12930902
genes like me logo Genes that share ontologies with CHTF18: view

Pathways & Interactions for CHTF18 Gene

SuperPathways for CHTF18 Gene

SuperPathway Contained pathways
1 Gastric Cancer Network 2
genes like me logo Genes that share pathways with CHTF18: view

Pathways by source for CHTF18 Gene

1 BioSystems pathway for CHTF18 Gene

Gene Ontology (GO) - Biological Process for CHTF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0007049 cell cycle IEA --
GO:1900264 positive regulation of DNA-directed DNA polymerase activity IDA 12930902
genes like me logo Genes that share ontologies with CHTF18: view

No data available for SIGNOR curated interactions for CHTF18 Gene

Drugs & Compounds for CHTF18 Gene

No Compound Related Data Available

Transcripts for CHTF18 Gene

Unigene Clusters for CHTF18 Gene

CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHTF18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CHTF18 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1: -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - -
SP15: - - - -
SP16: -
SP17: -
SP18: -

ExUns: 12c ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8: -
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for CHTF18 Gene

GeneLoc Exon Structure for
CHTF18
ECgene alternative splicing isoforms for
CHTF18

Expression for CHTF18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHTF18 Gene

Protein differential expression in normal tissues from HIPED for CHTF18 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHTF18 Gene



NURSA nuclear receptor signaling pathways regulating expression of CHTF18 Gene:

CHTF18

SOURCE GeneReport for Unigene cluster for CHTF18 Gene:

Hs.153850

Evidence on tissue expression from TISSUES for CHTF18 Gene

  • Nervous system(4.3)
  • Spleen(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with CHTF18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHTF18 Gene

Orthologs for CHTF18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHTF18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHTF18 33
  • 96.39 (n)
cow
(Bos Taurus)
Mammalia CHTF18 33 34
  • 81.36 (n)
dog
(Canis familiaris)
Mammalia CHTF18 33 34
  • 78.97 (n)
rat
(Rattus norvegicus)
Mammalia Chtf18 33
  • 77.1 (n)
mouse
(Mus musculus)
Mammalia Chtf18 33 16 34
  • 76.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CHTF18 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHTF18 33 34
  • 67.39 (n)
lizard
(Anolis carolinensis)
Reptilia CHTF18 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chtf18 33
  • 60.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15377 33
zebrafish
(Danio rerio)
Actinopterygii chtf18 33 34
  • 56.18 (n)
Dr.20903 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13212 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008869 33
  • 50.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta cutlet 33 34
  • 49.34 (n)
worm
(Caenorhabditis elegans)
Secernentea K08F4.1 34
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTF18 34 36
  • 24 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons CTF18 33
  • 41.45 (n)
rice
(Oryza sativa)
Liliopsida Os03g0264800 33
  • 43.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToOne
Species where no ortholog for CHTF18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHTF18 Gene

ENSEMBL:
Gene Tree for CHTF18 (if available)
TreeFam:
Gene Tree for CHTF18 (if available)

Paralogs for CHTF18 Gene

No data available for Paralogs for CHTF18 Gene

Variants for CHTF18 Gene

Sequence variations from dbSNP and Humsavar for CHTF18 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000149367 -- 792,103(+) GTTCA(C/T)GGGAT intron-variant
rs1000261081 -- 789,879(+) ACACA(A/G/T)CCTCC intron-variant, upstream-variant-2KB
rs1000336565 -- 791,520(+) GAACT(A/G)GAGCG intron-variant
rs1000419307 -- 793,793(+) GGGAC(G/T)TTCCC intron-variant
rs1000473170 -- 793,676(+) GTCTC(C/T)GTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHTF18 Gene

Variant ID Type Subtype PubMed ID
dgv4827n54 CNV loss 21841781
dgv4828n54 CNV gain 21841781
esv2422427 CNV duplication 17116639
esv3570042 CNV gain 25503493
esv3637582 CNV gain 21293372
esv3637584 CNV loss 21293372
esv3637585 CNV gain 21293372
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457312 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv482184 CNV gain 20164927
nsv517488 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571040 CNV loss 21841781
nsv571042 CNV loss 21841781
nsv571043 CNV loss 21841781
nsv571044 CNV loss 21841781
nsv571045 CNV gain 21841781
nsv817712 CNV loss 17921354
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for CHTF18 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.00; 92.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHTF18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHTF18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHTF18 Gene

Disorders for CHTF18 Gene

Relevant External Links for CHTF18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHTF18

No disorders were found for CHTF18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHTF18 Gene

Publications for CHTF18 Gene

  1. Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. (PMID: 18499658) Farina A … Hurwitz J (The Journal of biological chemistry 2008) 3 4 60
  2. A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity. (PMID: 17545166) Shiomi Y … Tsurimoto T (The Journal of biological chemistry 2007) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. (PMID: 12930902) Bermudez VP … Hurwitz J (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 60
  5. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. (PMID: 12766176) Merkle CJ … Chen J (The Journal of biological chemistry 2003) 3 4 60

Products for CHTF18 Gene

Sources for CHTF18 Gene

Content
Loading form....