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CHTF18 Gene

protein-coding   GIFtS: 52
GCID: GC16P000838

CTF18, Chromosome Transmission Fidelity Factor 18 Homolog...

(Previous name: chromosome 16 open reading frame 41)
(Previous symbol: C16orf41)
  Search for CHTF18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CTF18, Chromosome Transmission Fidelity Factor 18 Homolog (S.
Cerevisiae)1 2
     Ctf182
C16orf411 2 3     RUVBL2
CHL122 3 5     C321D2.3 (Novel Protein)2
hCTF182 3     C321D2.4 (Novel Protein)2
CTF183 5     Chromosome Transmission Fidelity Protein 18 Homolog2
Chromosome 16 Open Reading Frame 411     Homolog Of Yeast CHL122
C321D2.22     Some Homology With Holliday Junction DNA Helicase RUVB Like2
C321D2.32     EC 3.6.18
C321D2.42     

External Ids:    HGNC: 184351   Entrez Gene: 639222   Ensembl: ENSG000001275867   OMIM: 6132015   UniProtKB: Q8WVB63   

Export aliases for CHTF18 gene to outside databases

Previous GC identifers: GC16P000859 GC16P000778 GC16P000762


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHTF18 Gene:
CHTF18, CHTF8 (MIM 613202), and DCC1 (DSCC1; MIM 613203) are components of an alternative replication factor C
(RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et
al., 2003 (PubMed 12766176); Bermudez et al., 2003 (PubMed 12930902)).(supplied by OMIM, Dec 2009)

GeneCards Summary for CHTF18 Gene:
CHTF18 (CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot: CTF18_HUMAN, Q8WVB6
Function: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome
transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C
(CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to
single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA,
replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the
ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase
POLH

Gene Wiki entry for CHTF18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHTF18 gene promoter:
         Elk-1   Spz1   p53   Nkx2-5   E47   POU2F1a   HOXA5   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHTF18 promoter sequence
   Search Chromatin IP Primers for CHTF18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHTF18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

CHTF18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHTF18 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000838:  view genomic region     (about GC identifiers)

Start:
838,046 bp from pter      End:
850,737 bp from pter
Size:
12,692 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTF18_HUMAN, Q8WVB6 (See protein sequence)
Recommended Name: Chromosome transmission fidelity protein 18 homolog  
Size: 975 amino acids; 107383 Da
Subunit: Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5.
During assembly of the CTF18-RFC complex, CTF18 may first assemble into a subcomplex with RFC2, RFC3, RFC4 and
RFC5. CTF18 then interacts directly with CTF8, which in turn interacts with DCC1. The CTF18-RFC complex
associates with PCNA and with DNA polymerase POLH. The CTF18-RFC complex does not interact with the
Rad9/Rad1/Hus1 complex. CTF18 interacts with SMC1A and RAD21
Sequence caution: Sequence=AAH06437.1; Type=Erroneous initiation; Sequence=BAB15766.1; Type=Erroneous initiation;
Secondary accessions: B7ZBA2 D3DU68 Q7Z6Y4 Q7Z6Y6 Q9BR83 Q9BRG5 Q9H7K3
Alternative splicing: 3 isoforms:  Q8WVB6-1   Q8WVB6-2   Q8WVB6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHTF18: NX_Q8WVB6

Explore proteomics data for CHTF18 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys455
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for CHTF18 (Q8WVB6)
     PGLGKTTL  GPPGLGKTT 


    See CHTF18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071375.1  
    ENSEMBL proteins: 
     ENSP00000262315   ENSP00000456998   ENSP00000406252   ENSP00000399111   ENSP00000412015  
     ENSP00000454679   ENSP00000313029  

    CHTF18 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CHTF18

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type

    3 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q8WVB6

    ProtoNet protein and cluster: Q8WVB6

    UniProtKB/Swiss-Prot: CTF18_HUMAN, Q8WVB6
    Similarity: Belongs to the activator 1 small subunits family. CTF18 subfamily


    Find genes that share domains with CHTF18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTF18_HUMAN, Q8WVB6
    Function: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome
    transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C
    (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to
    single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA,
    replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the
    ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase
    POLH

         Enzyme Number (IUBMB): EC 3.6.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003677DNA binding IEA--
    GO:0005524ATP binding IEA--
    GO:0009378four-way junction helicase activity ----
    GO:0016887ATPase activity ----
         
    Find genes that share ontologies with CHTF18           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chtf18):
     cellular  endocrine/exocrine gland  growth/size/body  mortality/aging  reproductive system 

    Find genes that share phenotypes with CHTF18           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Chtf18tm1.1KhK for CHTF18

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHTF18
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHTF18

    miRNA
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    hsa-mir-484 (MIRT042013), hsa-mir-193b-3p (MIRT016447), hsa-mir-378a-5p (MIRT043987)

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    GenScript: all cDNA clones in your preferred vector: CHTF18 (NM_022092)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTF18_HUMAN, Q8WVB6: Nucleus. Note=Associates with chromatin during S phase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CHTF18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHTF18 About    
    See pathways by source

    SuperPathContained pathways About
    1Gastric cancer network 2
    Gastric cancer network 2


    1 BioSystems Pathway for CHTF18
        Gastric cancer network 2


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHTF18
    Interactions:

        GeneGlobe Interaction Network for CHTF18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHTF18 (Q8WVB63 ENSP000002623154) via UniProtKB, MINT, STRING, and/or I2D (see all 262)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    CHTF8P0CG133, ENSP000003812904I2D: score=1 STRING: ENSP00000381290
    DSCC1Q9BVC33, ENSP000003221804I2D: score=1 STRING: ENSP00000322180
    RFC4P352493, ENSP000002962734I2D: score=2 STRING: ENSP00000296273
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair ----
    GO:0006310DNA recombination ----
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with CHTF18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHTF18 (CTF18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHTF18 gene: 
    NM_022092.2  

    Unigene Cluster for CHTF18:

    CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
    Hs.153850  [show with all ESTs]
    Unigene Representative Sequence: AK024476
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000464728(uc002ckg.4) ENST00000262315(uc010bre.1 uc002cke.4)
    ENST00000570058 ENST00000563545 ENST00000479976 ENST00000455171(uc002ckf.4)
    ENST00000440239 ENST00000471202(uc010uus.1 uc010brf.3) ENST00000491530
    ENST00000426047 ENST00000484349 ENST00000569270 ENST00000567620 ENST00000565787
    ENST00000461268 ENST00000493715 ENST00000498439 ENST00000564940
    miRNA
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    hsa-miR-3164
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      QuantiFast Probe-based Assays in human, mouse, rat CHTF18

    Additional mRNA sequence: 

    AK024476.1 AK128869.1 AK293846.1 AK309804.1 BC006278.2 BC006437.1 BC018184.1 

    9 DOTS entries:

    DT.97840026  DT.423009  DT.100751771  DT.101975373  DT.97841074  DT.102828212  DT.92424897  DT.95375344 
    DT.120727801 

    Selected AceView cDNA sequences (see all 106):

    AW631061 BC006437 AK128869 BU633872 AI916173 AI341250 BQ962210 BM701214 
    BF513105 AA558991 BQ231004 BE795677 BE898071 AW236312 AI620989 BM674122 
    BM806765 BM127632 AA352175 AK024476 BU509771 BQ645686 CA421425 CK906217 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHTF18 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ·
    SP1:                                                                                -                                                                           
    SP2:                                                                                -                             -                                             
    SP3:                                                                                -                                                                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 12c ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for CHTF18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHTF18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCGCATT
    CHTF18 Expression
    About this image

    CHTF18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHTF18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.153850
        Custom PCR Arrays for CHTF18
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHTF18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHTF18 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chtf181 , 5 CTF18, chromosome transmission fidelity factor 18 homolog more5
    CTF18, chromosome transmission fidelity factor 181
    76.11(n)1
    75.9(a)1
      17 (12.83 cM)5
    2149011  NM_145409.21  NP_663384.21 
     257189265 
    chicken
    (Gallus gallus)
    Aves CHTF181 CTF18, chromosome transmission fidelity factor 18 homolog more 67.39(n)
    59.5(a)
      416531  NM_001278060.1  NP_001264989.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHTF186
    CTF18, chromosome transmission fidelity factor 18 ...
    54(a)
    1 ↔ 1
    GL343650.1(353075-386671)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153772 Xenopus laevis transcribed sequence with weak similarity more 74.95(n)    48014175 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.209032 Transcribed sequence with weak similarity to protein more 71.62(n)    CB360273.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cutlet1 cutlet 49.34(n)
    39.38(a)
      44637  NM_175955.3  NP_787969.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K08F4.16
    Protein K08F4.1 (K08F4.1) mRNA, complete cds
    25(a)
    1 ↔ 1
    IV(10122120-10126675) WBGene00010676
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTF18(YMR078C)4 Subunit of a complex with Ctf8p that shares some subunits more   --   13(424728-422503) 855102  NP_013795.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CTF181 CTF18 41.45(n)
    34.19(a)
      839431  NM_100352.2  NP_171966.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g02648001 Os03g0264800 43.53(n)
    35.29(a)
      4332344  NM_001056179.2  NP_001049644.2 


    ENSEMBL Gene Tree for CHTF18 (if available)
    TreeFam Gene Tree for CHTF18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHTF18 (see all 827)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124027031,2
    C,F--758667(+) AGGGCG/ATGGAG 1 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs2003728711,2
    --758764(+) CCCTTC/GTGTCA 1 -- us2k10--------
    rs99324841,2
    C,F--758766(+) CTTCTG/ATCACC 1 -- us2k12Minor allele frequency- A:0.05WA EU 711
    rs1923332311,2
    C,F--758772(+) TCACCA/GCCAGG 1 -- us2k11Minor allele frequency- G:0.00EU 593
    rs1995858501,2
    C--758782(+) GACACC/TGCCCA 1 -- us2k10--------
    rs1844932611,2
    C--758801(+) ACACCC/TGTGAG 1 -- us2k10--------
    rs1434889321,2
    C--758802(+) CACCCA/GTGAGC 1 -- us2k10--------
    rs2019140211,2
    --758807(+) GTGAGC/TGGCTT 1 -- us2k10--------
    rs22728961,2
    C,F--758965(+) CCAACG/CCACGA 1 -- us2k111Minor allele frequency- C:0.27NA WA CSA EA 375
    rs1880266141,2
    --758979(+) CCGCCC/TGGTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHTF18 (838046 - 850737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CHTF18 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2501n71CNV Loss21882294
    dgv2499n71CNV Loss21882294
    dgv2475n71CNV Loss21882294
    dgv2500n71CNV Loss21882294
    nsv904796CNV Loss21882294
    nsv904797CNV Loss21882294
    nsv817712CNV Loss17921354
    nsv904844CNV Loss21882294
    nsv526903CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHTF18
    DNA2.0 Custom Variant and Variant Library Synthesis for CHTF18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613201    OMIM disorders: --


    Find genes that share disorders with CHTF18           About GenesLikeMe


    Export disorders for CHTF18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHTF18 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CHTF18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A second proliferating cell nuclear antigen loader complex, Ctf18- replication factor C, stimulates DNA polymerase eta activity. (PubMed id 17545166)1, 2 Shiomi Y.... Tsurimoto T. (J. Biol. Chem. 2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. (PubMed id 12930902)1, 2 Bermudez V.P....Hurwitz J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    4. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. (PubMed id 12766176)1, 2 Merkle C.J.... Chen J. (J. Biol. Chem. 2003)
    5. A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. (PubMed id 12171929)1, 3 Ohta S....Tsurimoto T. (J. Biol. Chem. 2002)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63922 HGNC: 18435 AceView: CHTF18 Ensembl:ENSG00000127586 euGenes: HUgn63922
    ECgene: CHTF18 H-InvDB: CHTF18

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHTF18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHTF18 gene:
    Search GeneIP for patents involving CHTF18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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