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Aliases for CHTF18 Gene

Aliases for CHTF18 Gene

  • Chromosome Transmission Fidelity Factor 18 2 3
  • C16orf41 3 4
  • HCTF18 3 4
  • Ctf18 3 4
  • CHL12 3 4
  • CTF18, Chromosome Transmission Fidelity Factor 18 Homolog (S. Cerevisiae) 2
  • Some Homology With Holliday Junction DNA Helicase RUVB Like 3
  • CTF18, Chromosome Transmission Fidelity Factor 18 Homolog 3
  • Chromosome 16 Open Reading Frame 41 2
  • C321D2.3 (Novel Protein) 3
  • C321D2.4 (Novel Protein) 3
  • Homolog Of Yeast CHL12 3
  • C321D2.2 3
  • C321D2.3 3
  • C321D2.4 3
  • EC 3.6.1 63
  • RUVBL 3

External Ids for CHTF18 Gene

Previous HGNC Symbols for CHTF18 Gene

  • C16orf41

Previous GeneCards Identifiers for CHTF18 Gene

  • GC16P000859
  • GC16P000778
  • GC16P000838
  • GC16P000762
  • GC16P000815

Summaries for CHTF18 Gene

Entrez Gene Summary for CHTF18 Gene

  • CHTF18, CHTF8 (MIM 613202), and DCC1 (DSCC1; MIM 613203) are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]

GeneCards Summary for CHTF18 Gene

CHTF18 (Chromosome Transmission Fidelity Factor 18) is a Protein Coding gene. Among its related pathways are Gastric cancer network 2. GO annotations related to this gene include ATPase activity and four-way junction helicase activity.

UniProtKB/Swiss-Prot for CHTF18 Gene

  • Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.

Gene Wiki entry for CHTF18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHTF18 Gene

Genomics for CHTF18 Gene

Regulatory Elements for CHTF18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHTF18 Gene

Chromosome:
16
Start:
788,046 bp from pter
End:
800,737 bp from pter
Size:
12,692 bases
Orientation:
Plus strand

Genomic View for CHTF18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHTF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHTF18 Gene

Proteins for CHTF18 Gene

  • Protein details for CHTF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVB6-CTF18_HUMAN
    Recommended name:
    Chromosome transmission fidelity protein 18 homolog
    Protein Accession:
    Q8WVB6
    Secondary Accessions:
    • B7ZBA2
    • D3DU68
    • Q7Z6Y4
    • Q7Z6Y6
    • Q9BR83
    • Q9BRG5
    • Q9H7K3

    Protein attributes for CHTF18 Gene

    Size:
    975 amino acids
    Molecular mass:
    107383 Da
    Quaternary structure:
    • Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. During assembly of the CTF18-RFC complex, CTF18 may first assemble into a subcomplex with RFC2, RFC3, RFC4 and RFC5. CTF18 then interacts directly with CTF8, which in turn interacts with DCC1. The CTF18-RFC complex associates with PCNA and with DNA polymerase POLH. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. CTF18 interacts with SMC1A and RAD21.
    SequenceCaution:
    • Sequence=AAH06437.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15766.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHTF18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHTF18 Gene

Proteomics data for CHTF18 Gene at MOPED

Selected DME Specific Peptides for CHTF18 Gene

Post-translational modifications for CHTF18 Gene

  • Ubiquitination at Lys 455
  • Modification sites at PhosphoSitePlus

Domains & Families for CHTF18 Gene

Protein Domains for CHTF18 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WVB6

UniProtKB/Swiss-Prot:

CTF18_HUMAN :
  • Belongs to the activator 1 small subunits family. CTF18 subfamily.
Family:
  • Belongs to the activator 1 small subunits family. CTF18 subfamily.
genes like me logo Genes that share domains with CHTF18: view

Function for CHTF18 Gene

Molecular function for CHTF18 Gene

UniProtKB/Swiss-Prot Function:
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.

Enzyme Numbers (IUBMB) for CHTF18 Gene

Gene Ontology (GO) - Molecular Function for CHTF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CHTF18: view
genes like me logo Genes that share phenotypes with CHTF18: view

Animal Models for CHTF18 Gene

MGI Knock Outs for CHTF18:

Animal Model Products

CRISPR Products

miRNA for CHTF18 Gene

miRTarBase miRNAs that target CHTF18

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHTF18

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CHTF18 Gene

Localization for CHTF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHTF18 Gene

Nucleus. Note=Associates with chromatin during S phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHTF18 Gene COMPARTMENTS Subcellular localization image for CHTF18 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for CHTF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CHTF18: view

Pathways & Interactions for CHTF18 Gene

SuperPathways for CHTF18 Gene

Superpath Contained pathways
1 Gastric cancer network 2
genes like me logo Genes that share pathways with CHTF18: view

Pathways by source for CHTF18 Gene

1 BioSystems pathway for CHTF18 Gene

Gene Ontology (GO) - Biological Process for CHTF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CHTF18: view

No data available for SIGNOR curated interactions for CHTF18 Gene

Drugs & Compounds for CHTF18 Gene

No Compound Related Data Available

Transcripts for CHTF18 Gene

Unigene Clusters for CHTF18 Gene

CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHTF18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHTF18 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1: -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - -
SP15: - - - -
SP16: -
SP17: -
SP18: -

ExUns: 12c ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8: -
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for CHTF18 Gene

GeneLoc Exon Structure for
CHTF18
ECgene alternative splicing isoforms for
CHTF18

Expression for CHTF18 Gene

mRNA expression in normal human tissues for CHTF18 Gene

Protein differential expression in normal tissues from HIPED for CHTF18 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHTF18 Gene



SOURCE GeneReport for Unigene cluster for CHTF18 Gene Hs.153850

genes like me logo Genes that share expression patterns with CHTF18: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CHTF18 Gene

Orthologs for CHTF18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHTF18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHTF18 35
  • 81.36 (n)
  • 78.22 (a)
CHTF18 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHTF18 35
  • 78.97 (n)
  • 74.51 (a)
CHTF18 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chtf18 35
  • 76.11 (n)
  • 75.9 (a)
Chtf18 16
Chtf18 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHTF18 35
  • 96.39 (n)
  • 93.54 (a)
rat
(Rattus norvegicus)
Mammalia Chtf18 35
  • 77.1 (n)
  • 77.27 (a)
oppossum
(Monodelphis domestica)
Mammalia CHTF18 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves CHTF18 35
  • 67.39 (n)
  • 59.5 (a)
CHTF18 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHTF18 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chtf18 35
  • 60.34 (n)
  • 56.92 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15377 35
zebrafish
(Danio rerio)
Actinopterygii chtf18 35
  • 56.18 (n)
  • 51.47 (a)
Dr.20903 35
chtf18 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13212 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008869 35
  • 50.88 (n)
  • 37.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta cutlet 35
  • 49.34 (n)
  • 39.38 (a)
cutlet 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K08F4.1 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTF18 36
  • 24 (a)
OneToOne
CTF18 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CTF18 35
  • 41.45 (n)
  • 34.19 (a)
rice
(Oryza sativa)
Liliopsida Os03g0264800 35
  • 43.53 (n)
  • 35.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for CHTF18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHTF18 Gene

ENSEMBL:
Gene Tree for CHTF18 (if available)
TreeFam:
Gene Tree for CHTF18 (if available)

Paralogs for CHTF18 Gene

No data available for Paralogs for CHTF18 Gene

Variants for CHTF18 Gene

Sequence variations from dbSNP and Humsavar for CHTF18 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs577688 -- 792,921(+) TGAAA(C/G)GATGG intron-variant
rs742317 -- 796,798(-) ATCTC(A/G/T)CGGGC synonymous-codon, reference
rs742318 -- 791,710(+) GTGCT(C/G)AATTT intron-variant, utr-variant-5-prime
rs742319 -- 791,966(+) AGGTC(C/T)GTCTC intron-variant, utr-variant-5-prime
rs742320 -- 792,706(-) AGAGG(C/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHTF18 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2498n71 CNV Loss 21882294
dgv2499n71 CNV Loss 21882294
dgv2500n71 CNV Loss 21882294
nsv457312 CNV Loss 19166990
nsv517488 CNV Loss 19592680
nsv817712 CNV Loss 17921354
nsv904841 CNV Loss 21882294
nsv904842 CNV Loss 21882294
nsv904843 CNV Loss 21882294
nsv904844 CNV Loss 21882294
nsv904845 CNV Gain 21882294
dgv2501n71 CNV Loss 21882294
dgv2502n71 CNV Loss 21882294
nsv482184 CNV Gain 20164927

Variation tolerance for CHTF18 Gene

Residual Variation Intolerance Score: 99.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.00; 92.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHTF18 Gene

HapMap Linkage Disequilibrium report
CHTF18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHTF18 Gene

Disorders for CHTF18 Gene

Relevant External Links for CHTF18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHTF18
genes like me logo Genes that share disorders with CHTF18: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHTF18 Gene

Publications for CHTF18 Gene

  1. The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. (PMID: 20090939) Takahashi N. … De Veylder L. (PLoS Genet. 2010) 23 67
  2. Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast. (PMID: 18250106) Berkowitz K.M. … Jongens T.A. (Mol. Hum. Reprod. 2008) 23 67
  3. The INO80 chromatin remodeling complex functions in sister chromatid cohesion. (PMID: 17471029) Ogiwara H. … Seki M. (Cell Cycle 2007) 23 67
  4. Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. (PMID: 13678589) Kanellis P. … Durocher D. (Curr. Biol. 2003) 23 67
  5. A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. (PMID: 12171929) Ohta S. … Tsurimoto T. (J. Biol. Chem. 2002) 2 67

Products for CHTF18 Gene

Sources for CHTF18 Gene

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