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Aliases for CHSY3 Gene

Aliases for CHSY3 Gene

  • Chondroitin Sulfate Synthase 3 2 3
  • Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan 4-Beta-N-Acetylgalactosaminyltransferase II 3 4
  • N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase 3 3 4
  • Chondroitin Glucuronyltransferase 3 3 4
  • N-Acetylgalactosaminyltransferase 3 3 4
  • Carbohydrate Synthase 2 3 4
  • Chondroitin Synthase 2 3 4
  • ChSy-2 3 4
  • CHSY2 3 4
  • CSS3 3 4
  • Chondroitin Synthase-2 3
  • EC 2.4.1.175 4
  • EC 2.4.1.226 4

External Ids for CHSY3 Gene

Previous GeneCards Identifiers for CHSY3 Gene

  • GC05P129273
  • GC05P124432

Summaries for CHSY3 Gene

Entrez Gene Summary for CHSY3 Gene

  • CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003 [PubMed 12907687]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CHSY3 Gene

CHSY3 (Chondroitin Sulfate Synthase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include transferase activity, transferring glycosyl groups and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is B4GALNT4.

UniProtKB/Swiss-Prot for CHSY3 Gene

  • Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHSY3 Gene

Genomics for CHSY3 Gene

Regulatory Elements for CHSY3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHSY3 Gene

Chromosome:
5
Start:
129,903,408 bp from pter
End:
130,186,678 bp from pter
Size:
283,271 bases
Orientation:
Plus strand

Genomic View for CHSY3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHSY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHSY3 Gene

Proteins for CHSY3 Gene

  • Protein details for CHSY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70JA7-CHSS3_HUMAN
    Recommended name:
    Chondroitin sulfate synthase 3
    Protein Accession:
    Q70JA7
    Secondary Accessions:
    • B2RP97
    • Q76L22
    • Q86Y52

    Protein attributes for CHSY3 Gene

    Size:
    882 amino acids
    Molecular mass:
    100284 Da
    Cofactor:
    Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Cd(2+); Xref=ChEBI:CHEBI:48775; Note=Divalent metal cations. Highest activities are measured with Co(2+), Mn(2+) and Cd(2+).;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD43233.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CHSY3 Gene

Proteomics data for CHSY3 Gene at MOPED

Post-translational modifications for CHSY3 Gene

  • Glycosylation at Ser 100, Asn 155, Asn 279, Asn 710, and Asn 878
  • Modification sites at PhosphoSitePlus

Other Protein References for CHSY3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHSY3 Gene

Domains & Families for CHSY3 Gene

Gene Families for CHSY3 Gene

Protein Domains for CHSY3 Gene

Suggested Antigen Peptide Sequences for CHSY3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70JA7

UniProtKB/Swiss-Prot:

CHSS3_HUMAN :
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with CHSY3: view

Function for CHSY3 Gene

Molecular function for CHSY3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
UniProtKB/Swiss-Prot Function:
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1.

Enzyme Numbers (IUBMB) for CHSY3 Gene

Gene Ontology (GO) - Molecular Function for CHSY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008376 acetylgalactosaminyltransferase activity --
GO:0046872 metal ion binding IEA --
GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA --
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IEA --
genes like me logo Genes that share ontologies with CHSY3: view
genes like me logo Genes that share phenotypes with CHSY3: view

Animal Model Products

miRNA for CHSY3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHSY3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CHSY3 Gene

Localization for CHSY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHSY3 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHSY3 Gene COMPARTMENTS Subcellular localization image for CHSY3 gene
Compartment Confidence
golgi apparatus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for CHSY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with CHSY3: view

Pathways & Interactions for CHSY3 Gene

genes like me logo Genes that share pathways with CHSY3: view

Interacting Proteins for CHSY3 Gene

Gene Ontology (GO) - Biological Process for CHSY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CHSY3: view

No data available for SIGNOR curated interactions for CHSY3 Gene

Drugs & Compounds for CHSY3 Gene

(3) Drugs for CHSY3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine 5'-diphosphate Experimental Pharma 0
Cobalt Pharma 147
Manganese Pharma 30

(5) Additional Compounds for CHSY3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
Uridine diphosphate glucuronic acid
  • a-D-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
  • a-D-Glucopyranuronic acid ester with uridine 5'-pyrophosphate
  • alpha-D-Glucopyranuronic acid 1-P'-ester with uridine 5'-(trihydrogen diphosphate)
  • alpha-delta-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
  • alpha-delta-Glucopyranuronic acid 1-P'-ester with uridine 5'-(trihydrogen diphosphate)
2616-64-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with CHSY3: view

Transcripts for CHSY3 Gene

mRNA/cDNA for CHSY3 Gene

(6) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHSY3 Gene

Chondroitin sulfate synthase 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHSY3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHSY3 Gene

No ASD Table

Relevant External Links for CHSY3 Gene

GeneLoc Exon Structure for
CHSY3
ECgene alternative splicing isoforms for
CHSY3

Expression for CHSY3 Gene

mRNA expression in normal human tissues for CHSY3 Gene

mRNA differential expression in normal tissues according to GTEx for CHSY3 Gene

This gene is overexpressed in Artery - Tibial (x6.5) and Artery - Aorta (x6.1).

Protein differential expression in normal tissues from HIPED for CHSY3 Gene

This gene is overexpressed in Breast (24.1), Heart (21.9), Esophagus (12.2), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHSY3 Gene



SOURCE GeneReport for Unigene cluster for CHSY3 Gene Hs.213137

mRNA Expression by UniProt/SwissProt for CHSY3 Gene

Q70JA7-CHSS3_HUMAN
Tissue specificity: Detected at low levels in brain, cerebral cortex, uterus and small intestine.
genes like me logo Genes that share expression patterns with CHSY3: view

Protein tissue co-expression partners for CHSY3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CHSY3 Gene

Orthologs for CHSY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHSY3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHSY3 35
  • 91.78 (n)
  • 95 (a)
CHSY3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHSY3 35
  • 91.8 (n)
  • 95.01 (a)
CHSY3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chsy3 35
  • 86.85 (n)
  • 91.04 (a)
Chsy3 16
Chsy3 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHSY3 35
  • 99.58 (n)
  • 99.77 (a)
CHSY3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chsy3 35
  • 86.58 (n)
  • 90.36 (a)
chicken
(Gallus gallus)
Aves CHSY3 35
  • 76.99 (n)
  • 82.1 (a)
CHSY3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHSY3 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chsy3 35
  • 71.82 (n)
  • 77.05 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.984 35
zebrafish
(Danio rerio)
Actinopterygii chsy3 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9220 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sqv-5 35
  • 49.28 (n)
  • 42.55 (a)
sqv-5 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for CHSY3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHSY3 Gene

ENSEMBL:
Gene Tree for CHSY3 (if available)
TreeFam:
Gene Tree for CHSY3 (if available)

Paralogs for CHSY3 Gene

Paralogs for CHSY3 Gene

(3) SIMAP similar genes for CHSY3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHSY3: view

Variants for CHSY3 Gene

Sequence variations from dbSNP and Humsavar for CHSY3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_021174 -
VAR_027540 -

Structural Variations from Database of Genomic Variants (DGV) for CHSY3 Gene

Variant ID Type Subtype PubMed ID
nsv830488 CNV Gain 17160897
nsv882860 CNV Gain 21882294
dgv6322n71 CNV Loss 21882294
esv2671963 CNV Deletion 23128226
nsv471046 CNV Loss 18288195
nsv462445 CNV Loss 19166990
esv2663844 CNV Deletion 23128226
nsv327235 CNV Loss 16902084
esv2668447 CNV Deletion 23128226
nsv882863 CNV Gain 21882294
esv2730772 CNV Deletion 23290073

Variation tolerance for CHSY3 Gene

Residual Variation Intolerance Score: 13.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.19; 61.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHSY3 Gene

HapMap Linkage Disequilibrium report
CHSY3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHSY3 Gene

Disorders for CHSY3 Gene

Relevant External Links for CHSY3

Genetic Association Database (GAD)
CHSY3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHSY3
genes like me logo Genes that share disorders with CHSY3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHSY3 Gene

Publications for CHSY3 Gene

  1. Chondroitin sulfate synthase-3. Molecular cloning and characterization. (PMID: 12907687) Yada T. … Kimata K. (J. Biol. Chem. 2003) 2 23 67
  2. Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. (PMID: 18316376) Izumikawa T. … Kitagawa H. (J. Biol. Chem. 2008) 23 67
  3. Involvement of chondroitin sulfate synthase-3 (chondroitin synthase- 2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor. (PMID: 17253960) Izumikawa T. … Kitagawa H. (Biochem. J. 2007) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer. (PMID: 21468578) Kalathas D. … Vynios D.H. (Mol Med Rep 2011) 67

Products for CHSY3 Gene

Sources for CHSY3 Gene

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