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CHSY3 Gene

protein-coding   GIFtS: 54
GCID: GC05P129273

Chondroitin Sulfate Synthase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chondroitin Sulfate Synthase 31 2     N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase 32 3
CSS32 3 5     N-Acetylgalactosaminyltransferase 32 3
Carbohydrate Synthase 22 3     chSy-22
Chondroitin Glucuronyltransferase 32 3     Chondroitin Synthase-22
Chondroitin Synthase 22 3     ChSy-23
Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan
4-Beta-N-Acetylgalactosaminyltransferase II2 3
     EC 2.4.1.1753
CHSY22 3     EC 2.4.1.2263

External Ids:    HGNC: 242931   Entrez Gene: 3378762   Ensembl: ENSG000001981087   OMIM: 6099635   UniProtKB: Q70JA73   

Export aliases for CHSY3 gene to outside databases

Previous GC identifer: GC05P124432


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHSY3 Gene:
CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities
(Yada et al., 2003 (PubMed 12907687)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CHSY3 Gene:
CHSY3 (chondroitin sulfate synthase 3) is a protein-coding gene. Diseases associated with CHSY3 include morquio syndrome b, and sly syndrome. GO annotations related to this gene include glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity and N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity. An important paralog of this gene is CSGALNACT1.

UniProtKB/Swiss-Prot: CHSS3_HUMAN, Q70JA7
Function: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers
glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end
of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHSY3 gene promoter:
         STAT1   Pax-5   NF-kappaB2   RelA   Nkx2-5   NF-kappaB   NF-kappaB1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHSY3 promoter sequence
   Search Chromatin IP Primers for CHSY3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHSY3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.3   Ensembl cytogenetic band:  5q23.3   HGNC cytogenetic band: 5q13

CHSY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHSY3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P129273:  view genomic region     (about GC identifiers)

Start:
129,240,165 bp from pter      End:
129,522,327 bp from pter
Size:
282,163 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHSS3_HUMAN, Q70JA7 (See protein sequence)
Recommended Name: Chondroitin sulfate synthase 3  
Size: 882 amino acids; 100284 Da
Cofactor: Divalent cations. Highest activities are measured with cobalt, manganese and cadmium
Sequence caution: Sequence=CAD43233.1; Type=Erroneous initiation;
Secondary accessions: B2RP97 Q76L22 Q86Y52

Explore the universe of human proteins at neXtProt for CHSY3: NX_Q70JA7

Explore proteomics data for CHSY3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser100, Ser101, Asn155, Asn279, Asn710, Asn878
  • Modification sites at PhosphoSitePlus

  • See CHSY3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_787052.3  
    ENSEMBL proteins: 
     ENSP00000302629  
    Reactome Protein details: Q70JA7

    CHSY3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    B3GT: Beta 3-glycosyltransferases
    B4GT: Beta 4-glycosyltransferases

    1 InterPro protein domain:
     IPR008428 Chond_GalNAc

    Graphical View of Domain Structure for InterPro Entry Q70JA7

    ProtoNet protein and cluster: Q70JA7

    UniProtKB/Swiss-Prot: CHSS3_HUMAN, Q70JA7
    Similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family


    CHSY3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHSS3_HUMAN, Q70JA7
    Function: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers
    glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end
    of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1
    Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP +
    N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
    Catalytic activity: UDP-alpha-D-glucuronate +
    N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan

         Enzyme Numbers (IUBMB): EC 2.4.1.2261 EC 2.4.1.1751

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016757transferase activity, transferring glycosyl groups ----
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0046872metal ion binding IEA--
    GO:0047238glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA--
    GO:0050510N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IEA--
         
    CHSY3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHSY3:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHSY3
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    miRNA
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    miRTarBase miRNAs that target CHSY3:
    hsa-mir-484 (MIRT042238), hsa-mir-215-5p (MIRT024796), hsa-mir-192-5p (MIRT026772), hsa-mir-124-3p (MIRT022942)

    Block miRNA regulation of human, mouse, rat CHSY3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHSY3 (see all 22):
    hsa-miR-1263 hsa-let-7d hsa-miR-202 hsa-miR-575 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidCHSY3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHSS3_HUMAN, Q70JA7: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    CHSY3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHSY3 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.00
    Chondroitin sulfate biosynthesis0.41
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4dermatan sulfate biosynthesis
    dermatan sulfate biosynthesis
    chondroitin and dermatan biosynthesis0.00
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for CHSY3
        chondroitin and dermatan biosynthesis
    chondroitin sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis
    dermatan sulfate biosynthesis

    1 Reactome Pathway for CHSY3
        Chondroitin sulfate biosynthesis


    2 Kegg Pathways  (Kegg details for CHSY3):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
    Metabolic pathways


    CHSY3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHSY3
    Interactions:

        Search GeneGlobe Interaction Network for CHSY3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CHSY3 (ENSP000003026294) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BGNENSP000003273364STRING: ENSP00000327336
    CHPFENSP000002437764STRING: ENSP00000243776
    CHPF2ENSP000000353074STRING: ENSP00000035307
    CHST11ENSP000003057254STRING: ENSP00000305725
    CHST12ENSP000002587114STRING: ENSP00000258711
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0030206chondroitin sulfate biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--

    CHSY3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHSY3 (CHSS3)

    7 HMDB Compounds for CHSY3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CadmiumCd (see all 6)7440-43-9--
    CobaltCo (see all 6)7440-48-4--
    Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHSY3 gene: 
    NM_175856.4  

    Unigene Cluster for CHSY3:

    Chondroitin sulfate synthase 3
    Hs.213137  [show with all ESTs]
    Unigene Representative Sequence: AJ578034
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305031(uc003kvd.3) ENST00000507545
    miRNA
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    hsa-miR-1263 hsa-let-7d hsa-miR-202 hsa-miR-575 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-23a
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    Additional mRNA sequence: 

    AB086062.1 AB175496.1 AJ504664.2 AJ578034.2 AJ632296.1 AJ862728.1 AY726604.1 BC137325.1 

    2 DOTS entries:

    DT.40299060  DT.91741888 

    9 AceView cDNA sequences:

    AI379417 BI822321 AJ504664 AI076484 CB267553 AJ578034 D62790 BE739870 
    BE504376 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHSY3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATTTTAG
    CHSY3 Expression
    About this image

    CHSY3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHSY3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.213137

    UniProtKB/Swiss-Prot: CHSS3_HUMAN, Q70JA7
    Tissue specificity: Detected at low levels in brain, cerebral cortex, uterus and small intestine

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHSY3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHSY3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chsy31 , 5 chondroitin sulfate synthase 31, 5 86.85(n)1
    91.04(a)1
      18 (33.93 cM)5
    789231  NM_001081328.11  NP_001074797.11 
     591754015 
    chicken
    (Gallus gallus)
    Aves CHSY31 chondroitin sulfate synthase 3 76.99(n)
    82.1(a)
      415598  XM_413966.4  XP_413966.3 
    lizard
    (Anolis carolinensis)
    Reptilia CHSY36
    chondroitin sulfate synthase 3
    77(a)
    1 ↔ 1
    2(30769735-30869036)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia chsy31 chondroitin sulfate synthase 3 71.82(n)
    77.05(a)
      100494038  XM_002931723.2  XP_002931769.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chsy36
    chondroitin sulfate synthase 3
    70(a)
    1 ↔ 1
    10(16543642-16699699) ENSDARG00000069472
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92206
    --
    38(a)
    1 → many
    X(15480027-15484961)
    worm
    (Caenorhabditis elegans)
    Secernentea sqv-51 sqv-5 49.28(n)
    42.55(a)
      172851  NM_001026469.5  NP_001021640.2 


    ENSEMBL Gene Tree for CHSY3 (if available)
    TreeFam Gene Tree for CHSY3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHSY3 gene
    CSGALNACT12  CHPF2  B4GALNT32  CSGALNACT22  CHSY12  CHPF22  B4GALNT42  
    3 SIMAP similar genes for CHSY3 using alignment to 1 protein entry:     CHSS3_HUMAN:
    CHSY2    ChSy-2    CHSY1

    CHSY3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHSY3 (see all 5399)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340680571,2
    C--124668718(+) CAAAC-/AG/GA 
            
    AAGAT
    1 -- int11CSA 2
    rs710009491,2
    C--124668719(-) AATCT-/TCTGTTT 1 -- int11Minor allele frequency- TC:0.00NA 2
    rs339211,2
    C,F,H--129238568(-) GTTTTG/TCCCAG 1 -- us2k116Minor allele frequency- T:0.39NS EA NA WA CSA 931
    rs1931559751,2
    --129238641(+) CACAGA/CCAGGG 1 -- us2k10--------
    rs1851452771,2
    --129238668(+) CCATTA/CCTCCA 1 -- us2k10--------
    rs24312011,2
    C,F,A--129238809(+) GAAGGA/TAGTAC 1 -- us2k1 trp33Minor allele frequency- T:0.17NA WA 240
    rs1899962471,2
    --129238836(+) ACCCCA/TGACTA 1 -- us2k10--------
    rs339201,2
    C,F--129238943(-) AAAATC/TATTGT 1 -- us2k11Minor allele frequency- T:0.08NA 120
    rs1926450821,2
    --129239056(+) GTTCAC/TAGGCA 1 -- us2k10--------
    rs1838898511,2
    --129239140(+) GTTTGA/GATCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHSY3 (129240165 - 129490165 bp, first 250kb of CHSY3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CHSY3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671963CNV Deletion23128226
    esv2730772CNV Deletion23290073
    esv2663844CNV Deletion23128226
    esv2668447CNV Deletion23128226
    nsv462445CNV Loss19166990
    nsv327235CNV Loss16902084
    dgv6322n71CNV Loss21882294
    nsv471046CNV Loss18288195
    nsv830488CNV Gain17160897
    nsv882863CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609963    OMIM disorders: --

    5 diseases for CHSY3:    
    About MalaCards
    morquio syndrome b    sly syndrome    mucopolysaccharidoses    cerebritis
    colorectal cancer


    CHSY3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHSY3

    Export disorders for CHSY3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHSY3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CHSY3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chondroitin sulfate synthase-3. Molecular cloning and characterization. (PubMed id 12907687)1, 2, 3, 9 Yada T....Kimata K. (J. Biol. Chem. 2003)
    2. Involvement of chondroitin sulfate synthase-3 (chondroitin synthase- 2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor. (PubMed id 17253960)1, 9 Izumikawa T.... Kitagawa H. (Biochem. J. 2007)
    3. Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer. (PubMed id 21468578)1 Kalathas D....Vynios D.H. (Mol Med Rep 2011)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. (PubMed id 18316376)9 Izumikawa T....Kitagawa H. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 337876 HGNC: 24293 AceView: CSS3 Ensembl:ENSG00000198108 euGenes: HUgn337876
    ECgene: CHSY3 Kegg: 337876 H-InvDB: CHSY3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CHSY3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=CHSY3
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_446

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHSY3 gene:
    Search GeneIP for patents involving CHSY3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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