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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CHSY3 Gene

protein-coding GIFtS: 51
GCID: GC05P129273

chondroitin sulfate synthase 3

Explore 2 diseases affiliated with
CHSY3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chondroitin Sulfate Synthase 3¹ ²		N-Acetylgalactosaminyltransferase 3² ³
CSS3¹ ² ³ ⁵		CHSY-2¹
Carbohydrate Synthase 2² ³		ChSy-2³
Chondroitin Glucuronyltransferase 3² ³		Chondroitin Synthase-2²
Chondroitin Synthase 2² ³		ChSy-2³
Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan 4-Beta-N-Acetylgalactosaminyltransferase II² ³		EC 2.4.1.175³
CHSY2² ³		EC 2.4.1.226³
N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase 3² ³

External Ids:	HGNC: 24293¹	Entrez Gene: 337876²	Ensembl: ENSG00000198108⁷	OMIM: 609963⁵	UniProtKB: Q70JA7³

Export aliases for CHSY3 gene to outside databases

Previous GC identifer: GC05P124432

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHSY3:

CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities

(Yada et al., 2003 (PubMed 12907687)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: CHSS3_HUMAN, Q70JA7

Function: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers

glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of

the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CHSY3 gene promoter:
STAT1 Pax-5 NF-kappaB2 RelA Nkx2-5 NF-kappaB NF-kappaB1 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHSY3 promoter sequence

Search SABiosciences Chromatin IP Primers for CHSY3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHSY3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.3 Ensembl cytogenetic band: 5q23.3 HGNC cytogenetic band: 5q13

CHSY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHSY3 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P129273: view genomic region (about GC identifiers)

Start:	129,240,165 bp from pter	End:	129,522,327 bp from pter
Size:	282,163 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHSS3_HUMAN, Q70JA7 (See protein sequence)

Recommended Name: Chondroitin sulfate synthase 3

Size: 882 amino acids; 100284 Da

Cofactor: Divalent cations. Highest activities are measured with cobalt, manganese and cadmium

Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable)

Sequence caution: Sequence=CAD43233.1; Type=Erroneous initiation;

Secondary accessions: B2RP97 Q76L22 Q86Y52

Explore the universe of human proteins at neXtProt for CHSY3: NX_Q70JA7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q70JA7

CHSY3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_787052.3

ENSEMBL proteins:

ENSP00000302629

Reactome Protein details: Q70JA7
Human Recombinant Protein Products for CHSY3:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CHSY3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0032580	Golgi cisterna membrane	IEA	--

CHSY3 for ontologies About GeneDecksing

CHSY3 Antibody Products:

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Assay Products for CHSY3:

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	Uscn ELISAs and CLIAs for CHSY3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CHSY3 for domains About GeneDecksing

1 InterPro domain/family:

IPR008428 Chond_GalNAc

Graphical View of Domain Structure for InterPro Entry Q70JA7

ProtoNet protein and cluster: Q70JA7

UniProtKB/Swiss-Prot: CHSS3_HUMAN, Q70JA7

Similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CHSS3_HUMAN, Q70JA7

Function: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers

glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of

the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1

Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine +

beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP +

N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

Catalytic activity: UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan =

UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan

Enzyme Numbers (IUBMB): EC 2.4.1.226¹ EC 2.4.1.175¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0046872	metal ion binding	IEA	--
GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	IEA	--
GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	IEA	--

CHSY3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CHSY3:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CHSY3

miRNA Products:		OriGene 3'-UTR Clone: CHSY3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHSY3
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CHSY3 (see all 22):
		hsa-miR-1263 hsa-let-7d hsa-miR-202 hsa-miR-575 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: CHSY3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHSY3 (see all 4) OriGene shRNA RFP: CHSY3 OriGene siRNA: CHSY3
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CHSY3
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHSY3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHSY3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CHSY3
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		Sirion Biotech Customized stable knockdown cell line services for CHSY3 Sirion Biotech Customized inducible knockdown cell line services for CHSY3 Sirion Biotech Customized stable overexpressing cell line services for CHSY3 Sirion Biotech Customized inducible overexpressing cell line services for CHSY3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHSY3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/14 pathways (see all 14)
MPS VI - Maroteaux-Lamy syndrome	1.00	MPS VII - Sly syndrome	1.00
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS I - Hurler syndrome	1.00	MPS IIID - Sanfilippo syndrome D	1.00
Mucopolysaccharidoses	1.00	MPS IX - Natowicz syndrome	1.00

dermatan sulfate biosynthesis

dermatan sulfate biosynthesis	1.00	chondroitin and dermatan biosynthesis	0.38
Glycosaminoglycan biosynthesis - chondroitin sulfate	0.73	chondroitin sulfate biosynthesis (late stages)	0.32
chondroitin sulfate biosynthesis	0.64	Chondroitin sulfate biosynthesis	0.24

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Disease

Disease

1.00

A tetrasaccharide linker sequence is required for GAG synthesis

Chondroitin sulfate/dermatan sulfate metabolism

0.54

Pathway sources
See GeneCards unified pathways
Show all pathways

4 BioSystems Pathways for CHSY3

	chondroitin sulfate biosynthesis (late stages)
	chondroitin and dermatan biosynthesis
	chondroitin sulfate biosynthesis
	dermatan sulfate biosynthesis

5/18 Reactome Pathways for CHSY3 (see all 18)

	Chondroitin sulfate/dermatan sulfate metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	MPS II - Hunter syndrome

2 Kegg Pathways (Kegg details for CHSY3):

	Glycosaminoglycan biosynthesis - chondroitin sulfate
	Metabolic pathways

CHSY3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CHSY3

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/19 Interacting proteins for CHSY3 (ENSP00000302629⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BGN	ENSP00000327336⁴	STRING: ENSP00000327336
CHPF	ENSP00000243776⁴	STRING: ENSP00000243776
CHPF2	ENSP00000035307⁴	STRING: ENSP00000035307
CHST11	ENSP00000305725⁴	STRING: ENSP00000305725
CHST12	ENSP00000258711⁴	STRING: ENSP00000258711

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0030203	glycosaminoglycan metabolic process	TAS	--
GO:0030204	chondroitin sulfate metabolic process	TAS	--
GO:0030206	chondroitin sulfate biosynthetic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

CHSY3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CHSY3

7 HMDB Compounds for CHSY3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Cadmium	Cd (see all 6)	7440-43-9	--
Cobalt	Co (see all 6)	7440-48-4	--
Lactosamine	beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)	13000-25-4	--
Manganese	manganese	7439-96-5	--
Uridine 5'-diphosphate	5'-UDP (see all 9)	58-98-0	--
Uridine diphosphate glucuronic acid	UDP glucuronate (see all 41)	2616-64-0	--
Uridine diphosphate-N-acetylgalactosamine	UDP-N-acetyl-D-galactosamine (see all 17)	7277-98-7	--

Search CenterWatch for drugs/clinical trials and news about CHSY3 / CHSS3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CHSY3 gene:

NM_175856.4

Unigene Cluster for CHSY3:

Chondroitin sulfate synthase 3

Hs.213137 [show with all ESTs]

Unigene Representative Sequence: AJ578034

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000305031(uc003kvd.3) ENST00000507545

miRNA Products:		OriGene 3'-UTR Clone: CHSY3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHSY3
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CHSY3 (see all 22):
		hsa-miR-1263 hsa-let-7d hsa-miR-202 hsa-miR-575 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: CHSY3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CHSY3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHSY3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHSY3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHSY3 (NM_175856)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHSY3

Additional cDNA sequence:

AB086062.1 AB175496.1 AJ504664.2 AJ578034.2 AJ632296.1 AJ862728.1 AY726604.1 BC137325.1

2 DOTS entries:

DT.40299060 DT.91741888

9 AceView cDNA sequences:

BI822321 AI379417 CB267553 D62790 AJ504664 BE739870 AI076484 AJ578034

BE504376

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CHSY3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACATTTTAG

About this image

CHSY3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CHSY3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHSY3

SOURCE GeneReport for Unigene cluster: Hs.213137

UniProtKB/Swiss-Prot: CHSS3_HUMAN, Q70JA7

Tissue specificity: Detected at low levels in brain, cerebral cortex, uterus and small intestine

SABiosciences Custom PCR Arrays for CHSY3

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHSY3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHSY3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CHSY3 gene from 6/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Chsy3^{1 , 5}	chondroitin sulfate synthase 3^{1, 5}	87.15(n)¹ 91.5(a)¹		18 (33.93 cM)⁵ 78923¹ NM_001081328.1¹ NP_001074797.1¹ 59175401⁵
chicken (Gallus gallus)	Aves	CHSY3¹	chondroitin sulfate synthase 3	77.21(n) 82.53(a)		415598 XM_413966.3 XP_413966.3
lizard (Anolis carolinensis)	Reptilia	CHSY3⁶	--	76(a)	1 ↔ 1	2(30769735-30869036)
zebrafish (Danio rerio)	Actinopterygii	si:xx-bac7cse.2⁶	si:xx-bac7cse.2	69(a)	1 ↔ 1	10(16543642-16699699)
fruit fly (Drosophila melanogaster)	Insecta	CG9220⁶	--	36(a)	1 → many	X(15480027-15484961)
worm (Caenorhabditis elegans)	Secernentea	sqv-5¹	Protein SQV-5	49.28(n) 42.55(a)		172851 NM_001026469.4 NP_001021640.2

ENSEMBL Gene Tree for CHSY3 (if available)
TreeFam Gene Tree for CHSY3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CHSY3 gene

CSGALNACT1² CHPF² CSGALNACT2² CHPF2² CHSY1²

3 SIMAP similar genes for CHSY3 using alignment to 1 protein entry: CHSS3_HUMAN:

CHSY2 ChSy-2 CHSY1

CHSY3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs33921^1,2	C,F,H	--	129238568(-)	`GTTTTG/TCCCAG`	1	--	us2k¹		16		NS EA NA WA CSA	931
rs193155975^1,2		--	129238641(+)	`CACAGA/CCAGGG`	1	--	us2k¹		0	--	--	--	--
rs185145277^1,2		--	129238668(+)	`CCATTA/CCTCCA`	1	--	us2k¹		0	--	--	--	--
rs2431201^1,2	C,A	--	129238809(+)	`GAAGGA/TAGTAC`	1	--	us2k¹ trp³		3		NA WA	240
rs189996247^1,2		--	129238836(+)	`ACCCCA/TGACTA`	1	--	us2k¹		0	--	--	--	--
rs33920^1,2	C,F	--	129238943(-)	`AAAATC/TATTGT`	1	--	us2k¹		1		NA	120
rs192645082^1,2		--	129239056(+)	`GTTCAC/TAGGCA`	1	--	us2k¹		0	--	--	--	--
rs183889851^1,2		--	129239140(+)	`GTTTGA/GATCTT`	1	--	us2k¹		0	--	--	--	--
rs75778088^1,2		--	129239178(+)	`CCATTT/CCTCCA`	1	--	us2k¹		1		NA	120
rs138166277^1,2		--	129239274(+)	`GAGCCA/GAGGGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CHSY3 (129240165 - 129490165 bp, first 250kb of CHSY3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CHSY3
1 Indel: 12759

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CHSY3 for disorders           About GeneDecksing

OMIM gene information: 609963    OMIM disorders: --

2 diseases for CHSY3:    About MalaCards

colorectal cancer cerebritis

Export disorders for CHSY3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CHSY3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CHSY3)

Utopia: connect your pdf to the dynamic
world of online information

Chondroitin sulfate synthase-3. Molecular cloning and characterization. (PubMed id 12907687)^{1, 2, 3, 9} Yada T....Kimata K. (2003)
Involvement of chondroitin sulfate synthase-3 (chondroitin synthase- 2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor. (PubMed id 17253960)^{1, 9} Izumikawa T.... Kitagawa H. (2007)
Chondroitin synthases I, II, III and chondroitin sulf ate glucuronyltransferase expression in colorectal cancer. (PubMed id 21468578)¹ Kalathas D....Vynios D.H. (2011)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)¹ Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Identification of Chondroitin Sulfate Glucuronyltransferase as Chondroitin Synthase-3 Involved in Chondroitin Polymerization: CHONDROITIN POLYMERIZATION IS ACHIEVED BY MULTIPLE ENZYME COMPLEXES CONSISTING OF CHONDROITIN SYNTHASE FAMILY MEMBERS. (PubMed id 18316376)⁹ Izumikawa T....Kitagawa H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 337876	HGNC: 24293	AceView: CSS3	Ensembl:ENSG00000198108	euGenes: HUgn337876
ECgene: CHSY3	Kegg: 337876	H-InvDB: CHSY3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CHSY3	Pharmacogenomics, SNPs, Pathways
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_446

Intellectual Property for CHSY3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CHSY3 gene:
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GeneCards and IP:
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