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CHST9 Gene

protein-coding   GIFtS: 53
GCID: GC18M024495

Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 91 2     N-Acetylgalactosamine 4-O-Sulfotransferase 22
GalNAc-4-O-Sulfotransferase 22 3     EC 2.8.2.-3
GALNAC4ST-22     GalNAc-4-ST23
Carbohydrate Sulfotransferase 92     GalNAc4ST-23
GalNAc-4-Sulfotransferase 22     N-Acetylgalactosamine-4-O-Sulfotransferase 23

External Ids:    HGNC: 198981   Entrez Gene: 835392   Ensembl: ENSG000001540807   OMIM: 6101915   UniProtKB: Q7L1S53   

Export aliases for CHST9 gene to outside databases

Previous GC identifers: GC18M024226 GC18M024383 GC18M022747 GC18M022749 GC18M024486 GC18M021345


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHST9 Gene:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane,
and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in
both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins,
glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic
development. Alternatively spliced transcript variants have been described for this gene. (provided by RefSeq,
Aug 2011)

GeneCards Summary for CHST9 Gene:
CHST9 (carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9) is a protein-coding gene. Diseases associated with CHST9 include morquio syndrome b, and sly syndrome. GO annotations related to this gene include N-acetylgalactosamine 4-O-sulfotransferase activity. An important paralog of this gene is CHST12.

UniProtKB/Swiss-Prot: CHST9_HUMAN, Q7L1S5
Function: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues
in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin,
by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than
toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active
toward chondroitin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHST9 gene promoter:
         MEF-2A   LHX3b/Lhx3b   LHX3a/Lhx3a   CUTL1   aMEF-2   Nkx2-5   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST9 promoter sequence
   Search Chromatin IP Primers for CHST9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHST9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2   Ensembl cytogenetic band:  18q11.2   HGNC cytogenetic band: 18q11.2

CHST9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST9 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M024495:  view genomic region     (about GC identifiers)

Start:
24,495,595 bp from pter      End:
24,765,289 bp from pter
Size:
269,695 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHST9_HUMAN, Q7L1S5 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 9  
Size: 443 amino acids; 52055 Da
Caution: It is uncertain whether Met-1 or Met-8 is the initiator
Sequence caution: Sequence=AAH25764.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAK01862.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAK30370.1;
Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q6UX69 Q9BXH3 Q9BXH4 Q9BZW9
Alternative splicing: 2 isoforms:  Q7L1S5-1   Q7L1S5-2   

Explore the universe of human proteins at neXtProt for CHST9: NX_Q7L1S5

Explore proteomics data for CHST9 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr52, Asn159, Asn243, Asn324, Asn437
  • Modification sites at PhosphoSitePlus

  • See CHST9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243245.1  NP_113610.2  

    ENSEMBL proteins: 
     ENSP00000284224   ENSP00000462852   ENSP00000464655  
    Reactome Protein details: Q7L1S5

    CHST9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for CHST9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR005331 Sulfotransferase
     IPR018011 Carb_sulfotransferase-rel

    Graphical View of Domain Structure for InterPro Entry Q7L1S5

    ProtoNet protein and cluster: Q7L1S5

    UniProtKB/Swiss-Prot: CHST9_HUMAN, Q7L1S5
    Similarity: Belongs to the sulfotransferase 2 family


    CHST9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHST9_HUMAN, Q7L1S5
    Function: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues
    in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin,
    by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than
    toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active
    toward chondroitin

         Enzyme Number (IUBMB): EC 2.8.2.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001537N-acetylgalactosamine 4-O-sulfotransferase activity ISS--
    GO:0008146sulfotransferase activity ----
         
    CHST9 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHST9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHST9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST9

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHST9:
    hsa-mir-335-5p (MIRT018484), hsa-mir-92a-3p (MIRT048939)

    Block miRNA regulation of human, mouse, rat CHST9 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CHST9:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidCHST9 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CHST9
    Predesigned siRNA for gene silencing in human, mouse, rat CHST9

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    GenScript: all cDNA clones in your preferred vector: CHST9 (NM_031422)
    Sino Biological Human cDNA Clone for CHST9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST9

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHST9_HUMAN, Q7L1S5: Isoform 1: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    CHST9_HUMAN, Q7L1S5: Isoform 2: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular4
    endoplasmic reticulum2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region IEA--
    GO:0016021integral component of membrane NAS11139592

    CHST9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHST9 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    Chondroitin sulfate biosynthesis0.41
    3Biological oxidations
    metapathway biotransformation0.42
    4Metabolism
    Metabolism0.38
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CHST9
        metapathway biotransformation


    1 Reactome Pathway for CHST9
        Chondroitin sulfate biosynthesis



    CHST9 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHST9
    Interactions:

        Search GeneGlobe Interaction Network for CHST9

    1 Interacting protein for CHST9 (Q7L1S53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LHCGRP228883I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006790sulfur compound metabolic process IDA11445554
    GO:0016051carbohydrate biosynthetic process IEA--
    GO:0030166proteoglycan biosynthetic process ISS--
    GO:0030203glycosaminoglycan metabolic process TAS--

    CHST9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHST9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHST9 gene (3 alternative transcripts): 
    NM_001256316.1  NM_031422.5  NM_001243848.1  

    Unigene Cluster for CHST9:

    Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
    Hs.44584  [show with all ESTs]
    Unigene Representative Sequence: AK124319
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284224(uc002kwd.3 uc002kwe.3 uc021uij.1) ENST00000581714
    ENST00000580774
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHST9 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CHST9:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidCHST9 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHST9 (NM_031422)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST9
    Primer
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    OriGene qPCR primer pairs and template standards for CHST9
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST9
      QuantiTect SYBR Green Assays in human, mouse, rat CHST9
      QuantiFast Probe-based Assays in human, mouse, rat CHST9

    Additional mRNA sequence: AK124319.1 

    4 DOTS entries:

    DT.101977841  DT.100018056  DT.91731346  DT.100647539 

    Selected AceView cDNA sequences (see all 39):

    AK093349 AJ707539 AY358488 BC025764 AI928085 BX105249 BM993308 BI711441 
    AX748069 AW293362 BU678771 AF332472 AI288691 BI966139 NM_031422 BM919514 
    AW003350 AF239821 AI927495 BU685729 AA417086 BE551839 BF205671 AI655266 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHST9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATATTTT
    CHST9 Expression
    About this image


    CHST9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    CHST9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHST9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.44584

    UniProtKB/Swiss-Prot: CHST9_HUMAN, Q7L1S5
    Tissue specificity: Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary
    gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland.
    Weakly or not expressed in heart, liver and spinal cord

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHST9 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst91 , 5 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase more1, 5 80.91(n)1
    78.4(a)1
      18 (8.85 cM)5
    713671  NM_199055.21  NP_951010.11 
     154519245 
    chicken
    (Gallus gallus)
    Aves CHST91 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase more 67.81(n)
    67.81(a)
      421089  XM_004939813.1  XP_004939870.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHST96
    carbohydrate (N-acetylgalactosamine 4-0) sulfotran...
    64(a)
    1 ↔ 1
    4(36354139-36427063)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG139376
    CG140246
    --
    23(a)
    19(a)
    many ↔ many
    many ↔ many
    3L(1876551-1883041)
    2L(5311311-5314885)


    ENSEMBL Gene Tree for CHST9 (if available)
    TreeFam Gene Tree for CHST9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHST9 gene
    CHST122  CHST132  CHST112  CHST102  CHST82  CHST142  
    5 SIMAP similar genes for CHST9 using alignment to 2 protein entries:     CHST9_HUMAN (see all proteins):
    CHST11    CHST8    CHST13    CHST10    CHST12

    CHST9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHST9 (see all 5579)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23075611,2
    C,F--21353746(+) TGATAAGTGTT/-
            
    GTACA
    2 -- int14Minor allele frequency- -:0.32EU NA EA 342
    rs30842521,2
    C--21355505(+) TTAAT-/TAA   
      T
    /TTAA
    AGACT
    2 -- int10--------
    rs1128754051,2
    C--21355516(+) AGGGGA/GCATGG 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs353692191,2
    C--21368270(+) CACTA-/TTTTCT 2 -- int12Minor allele frequency- T:0.25NA 4
    rs723285241,2
    C--21381749(+) TTTTG-/T/TT  
            
    TTTTT
    2 -- int11CSA 2
    rs105738201,2
    C--21385410(+) TTCTG-/T/TT  
            
    TTTTT
    2 -- int11NA 2
    rs1510585241,2
    --21421877(+) AGCAGA/GAGACG 2 -- int10--------
    rs1409499891,2
    C--21421934(+) AGTGAC/TCAACT 2 -- int10--------
    rs1859360851,2
    --21421972(+) GAAGAC/TGAGGA 2 -- int10--------
    rs746255801,2
    --21421973(+) AAGACG/CAGGAC 2 -- int11Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for CHST9 (24495595 - 24745595 bp, first 250kb of CHST9)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CHST9 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716888CNV Deletion23290073
    esv2716889CNV Deletion23290073
    esv2658895CNV Deletion23128226
    esv2668079CNV Deletion23128226
    nsv820910CNV Deletion20802225
    esv2676360CNV Deletion23128226
    nsv2236CNV Insertion18451855
    esv1411247CNV Insertion17803354
    nsv528945CNV Loss19592680
    nsv909477CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610191    OMIM disorders: --

    7 diseases for CHST9:    
    About MalaCards
    morquio syndrome b    sly syndrome    dental caries    mucopolysaccharidoses
    prostatitis    breast cancer    endotheliitis


    CHST9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHST9
    Human Genome Epidemiology (HuGE) Navigator: CHST9 (1 document)

    Export disorders for CHST9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHST9 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CHST9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of an N-acetylgalactosamine-4-O- sulfotransferase that transfers sulfate to terminal and non-terminal beta 1,4-linked N-acetylgalactosamine. (PubMed id 11139592)1, 2, 3 Kang H.-G.... Schachner M. (J. Biol. Chem. 2001)
    2. Molecular cloning and expression of two distinct human N- acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1->4GlcNAc beta 1->R in both N- and O-glycans. (PubMed id 11445554)1, 2, 3 Hiraoka N.... Fukuda M. (Glycobiology 2001)
    3. Examination of copy number variations of CHST9 in multiple types of hematologic malignancies. (PubMed id 21156230)1, 4 Zhao X....Wan J. (Cancer Genet. Cytogenet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PubMed id 23897914)1 Wang H....O'Brodovich H.M. (Pediatrics 2013)
    8. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
    9. Genome-wide association scan of dental caries in the permanent dentition. (PubMed id 23259602)1 Wang X....Marazita M.L. (BMC Oral Health 2012)
    10. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83539 HGNC: 19898 AceView: CHST9 Ensembl:ENSG00000154080 euGenes: HUgn83539
    ECgene: CHST9 H-InvDB: CHST9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHST9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHST9 gene:
    Search GeneIP for patents involving CHST9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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