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Aliases for CHST9 Gene

Aliases for CHST9 Gene

  • Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 9 2 3
  • GalNAc-4-O-Sulfotransferase 2 3 4
  • GALNAC4ST-2 3 4
  • N-Acetylgalactosamine 4-O-Sulfotransferase 2 3
  • N-Acetylgalactosamine-4-O-Sulfotransferase 2 4
  • Carbohydrate Sulfotransferase 9 3
  • GalNAc-4-Sulfotransferase 2 3
  • GalNAc-4-ST2 4
  • GalNAc4ST2 3
  • EC 2.8.2.- 4

External Ids for CHST9 Gene

Summaries for CHST9 Gene

Entrez Gene Summary for CHST9 Gene

  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST9 Gene

CHST9 (Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 9) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include N-acetylgalactosamine 4-O-sulfotransferase activity. An important paralog of this gene is CHST13.

UniProtKB/Swiss-Prot for CHST9 Gene

  • Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST9 Gene

Genomics for CHST9 Gene

Genomic Location for CHST9 Gene

Start:
26,906,481 bp from pter
End:
27,185,338 bp from pter
Size:
278,858 bases
Orientation:
Minus strand

Genomic View for CHST9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHST9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST9 Gene

Regulatory Elements for CHST9 Gene

Proteins for CHST9 Gene

  • Protein details for CHST9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L1S5-CHST9_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 9
    Protein Accession:
    Q7L1S5
    Secondary Accessions:
    • Q6UX69
    • Q9BXH3
    • Q9BXH4
    • Q9BZW9

    Protein attributes for CHST9 Gene

    Size:
    443 amino acids
    Molecular mass:
    52055 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH25764.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK01862.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK30370.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHST9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHST9 Gene

Proteomics data for CHST9 Gene at MOPED

Post-translational modifications for CHST9 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr52, Asn159, Asn243, Asn324, and Asn437

Other Protein References for CHST9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHST9 Gene

Domains for CHST9 Gene

Gene Families for CHST9 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for CHST9 Gene

UniProtKB/Swiss-Prot:

CHST9_HUMAN
Family:
  • Belongs to the sulfotransferase 2 family.:
    • Q7L1S5
genes like me logo Genes that share domains with CHST9: view

Function for CHST9 Gene

Molecular function for CHST9 Gene

UniProtKB/Swiss-Prot Function: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin

Enzyme Numbers (IUBMB) for CHST9 Gene

Gene Ontology (GO) - Molecular Function for CHST9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity ISS --
GO:0008146 sulfotransferase activity --
genes like me logo Genes that share ontologies with CHST9: view

miRNA for CHST9 Gene

miRTarBase miRNAs that target CHST9

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHST9 Gene

Localization for CHST9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST9 Gene

Isoform 1: Golgi apparatus membrane; Single-pass type II membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST9 Gene COMPARTMENTS Subcellular localization image for CHST9 gene
Compartment Confidence
golgi apparatus 5
extracellular 4
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHST9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0016021 integral component of membrane NAS 11139592
genes like me logo Genes that share ontologies with CHST9: view

Pathways for CHST9 Gene

genes like me logo Genes that share pathways with CHST9: view

Pathways by source for CHST9 Gene

Interacting Proteins for CHST9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000284224%0d%0a9606.ENSP00000294954%0d%0a
Selected Interacting proteins: ENSP00000284224 Q7L1S5-CHST9_HUMAN for CHST9 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CHST9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006790 sulfur compound metabolic process IDA 11445554
GO:0016051 carbohydrate biosynthetic process IEA --
GO:0030166 proteoglycan biosynthetic process ISS --
GO:0030203 glycosaminoglycan metabolic process TAS --
genes like me logo Genes that share ontologies with CHST9: view

Transcripts for CHST9 Gene

Unigene Clusters for CHST9 Gene

Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHST9 Gene

No ASD Table

Relevant External Links for CHST9 Gene

GeneLoc Exon Structure for
CHST9
ECgene alternative splicing isoforms for
CHST9

Expression for CHST9 Gene

mRNA expression in normal human tissues for CHST9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST9 Gene

This gene is overexpressed in Minor Salivary Gland (10.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CHST9 Gene

SOURCE GeneReport for Unigene cluster for CHST9 Gene Hs.44584

mRNA Expression by UniProt/SwissProt for CHST9 Gene

Q7L1S5-CHST9_HUMAN
Tissue specificity: Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland. Weakly or not expressed in heart, liver and spinal cord.
genes like me logo Genes that share expressions with CHST9: view

Orthologs for CHST9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST9 36
  • 99.25 (n)
  • 99.1 (a)
CHST9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHST9 36
  • 86.25 (n)
  • 85.78 (a)
CHST9 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHST9 36
  • 89.74 (n)
  • 88.01 (a)
CHST9 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chst9 36
  • 80.91 (n)
  • 78.4 (a)
Chst9 16
Chst9 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHST9 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHST9 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chst9 36
  • 80.55 (n)
  • 77.97 (a)
chicken
(Gallus gallus)
Aves CHST9 36
  • 67.81 (n)
  • 67.81 (a)
CHST9 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST9 37
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13937 37
  • 23 (a)
ManyToMany
CG14024 37
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 22 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
Species with no ortholog for CHST9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CHST9 Gene

ENSEMBL:
Gene Tree for CHST9 (if available)
TreeFam:
Gene Tree for CHST9 (if available)

Paralogs for CHST9 Gene

Paralogs for CHST9 Gene

Selected SIMAP similar genes for CHST9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHST9: view

Variants for CHST9 Gene

Sequence variations from dbSNP and Humsavar for CHST9 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs149424 -- 26,937,683(+) TAATT(C/T)GCCTC intron-variant
rs151252 -- 26,940,373(-) cccat(C/G)tccaa intron-variant
rs163042 -- 26,952,372(+) GACAT(C/T)AACAA intron-variant
rs163047 -- 26,946,998(+) ctata(C/T)gtgct intron-variant
rs163048 -- 26,943,753(+) GTTCT(A/G)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST9 Gene

Variant ID Type Subtype PubMed ID
nsv833600 CNV Gain 17160897
nsv909472 CNV Gain 21882294
esv2668079 CNV Deletion 23128226
esv1411247 CNV Insertion 17803354
esv2676360 CNV Deletion 23128226
nsv512523 CNV Loss 21212237
esv2716888 CNV Deletion 23290073
esv2658895 CNV Deletion 23128226
esv25443 CNV Gain 19812545
nsv820910 CNV Deletion 20802225
esv2716889 CNV Deletion 23290073
dgv3398n71 CNV Gain 21882294
nsv909475 CNV Loss 21882294
nsv909476 CNV Loss 21882294
nsv2236 CNV Insertion 18451855
nsv909477 CNV Loss 21882294
nsv528945 CNV Loss 19592680

Relevant External Links for CHST9 Gene

HapMap Linkage Disequilibrium report
CHST9

Disorders for CHST9 Gene

Relevant External Links for CHST9

Genetic Association Database (GAD)
CHST9
Human Genome Epidemiology (HuGE) Navigator
CHST9
genes like me logo Genes that share disorders with CHST9: view

No data available for UniProtKB/Swiss-Prot for CHST9 Gene

Publications for CHST9 Gene

  1. Molecular cloning and expression of an N-acetylgalactosamine-4-O- sulfotransferase that transfers sulfate to terminal and non-terminal beta 1,4-linked N-acetylgalactosamine. (PMID: 11139592) Kang H.-G. … Schachner M. (J. Biol. Chem. 2001) 2 3 4
  2. Molecular cloning and expression of two distinct human N- acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1->4GlcNAc beta 1->R in both N- and O-glycans. (PMID: 11445554) Hiraoka N. … Fukuda M. (Glycobiology 2001) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CHST9 Gene

Sources for CHST9 Gene

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