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Aliases for CHST9 Gene

Aliases for CHST9 Gene

  • Carbohydrate Sulfotransferase 9 2 3 5
  • Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 9 2 3
  • GalNAc-4-O-Sulfotransferase 2 3 4
  • GALNAC4ST-2 3 4
  • N-Acetylgalactosamine 4-O-Sulfotransferase 2 3
  • N-Acetylgalactosamine-4-O-Sulfotransferase 2 4
  • GalNAc-4-Sulfotransferase 2 3
  • GalNAc-4-ST2 4
  • GalNAc4ST2 3
  • EC 2.8.2.- 4

External Ids for CHST9 Gene

Previous GeneCards Identifiers for CHST9 Gene

  • GC18M024226
  • GC18M024383
  • GC18M022747
  • GC18M022749
  • GC18M024486
  • GC18M021345
  • GC18M024495

Summaries for CHST9 Gene

Entrez Gene Summary for CHST9 Gene

  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST9 Gene

CHST9 (Carbohydrate Sulfotransferase 9) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. GO annotations related to this gene include sulfotransferase activity and N-acetylgalactosamine 4-O-sulfotransferase activity. An important paralog of this gene is CHST8.

UniProtKB/Swiss-Prot for CHST9 Gene

  • Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST9 Gene

Genomics for CHST9 Gene

Regulatory Elements for CHST9 Gene

Enhancers for CHST9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F027057 0.5 ENCODE 25.8 +127.7 127695 0.6 SMARCA4 POLR2A YY1 CHST9 GC18P027036 GC18M027101
GH18F027136 1.1 Ensembl ENCODE 11.3 +48.9 48938 0.4 ELF3 MLX ARID4B DMAP1 ZNF48 RARA CEBPB TGIF2 MIER3 CEBPA CHST9 GC18M027137 GC18M027101
GH18F028083 1.4 VISTA Ensembl ENCODE 6.1 -901.1 -901058 5.0 SOX13 L3MBTL2 OVOL3 CEBPB CEBPG FEZF1 ZNF843 YY1 SMARCA4 POLR2A CDH2 CHST9 GC18M028093 GC18M028006 PIR33397
GH18F027227 0.4 ENCODE 19.3 -42.6 -42625 1.0 KDM1A CHST9 PIR61180 GC18M027230
GH18F027223 0.4 ENCODE 11.2 -38.5 -38531 1.0 ZNF341 ZIC2 CHST9 LINC01908
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHST9 on UCSC Golden Path with GeneCards custom track

Promoters for CHST9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001812210 238 1400 HIC1 GLIS2 SP3 L3MBTL2 ZBTB26 EZH2

Genomic Location for CHST9 Gene

Chromosome:
18
Start:
26,906,481 bp from pter
End:
27,185,338 bp from pter
Size:
278,858 bases
Orientation:
Minus strand

Genomic View for CHST9 Gene

Genes around CHST9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHST9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHST9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST9 Gene

Proteins for CHST9 Gene

  • Protein details for CHST9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L1S5-CHST9_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 9
    Protein Accession:
    Q7L1S5
    Secondary Accessions:
    • Q6UX69
    • Q9BXH3
    • Q9BXH4
    • Q9BZW9

    Protein attributes for CHST9 Gene

    Size:
    443 amino acids
    Molecular mass:
    52055 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH25764.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK01862.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK30370.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHST9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHST9 Gene

Post-translational modifications for CHST9 Gene

  • Glycosylation at Thr 52, Asn 159, Asn 243, Asn 324, and Asn 437
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST9 Gene

No data available for DME Specific Peptides for CHST9 Gene

Domains & Families for CHST9 Gene

Gene Families for CHST9 Gene

Protein Domains for CHST9 Gene

Suggested Antigen Peptide Sequences for CHST9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L1S5

UniProtKB/Swiss-Prot:

CHST9_HUMAN :
  • Belongs to the sulfotransferase 2 family.
Family:
  • Belongs to the sulfotransferase 2 family.
genes like me logo Genes that share domains with CHST9: view

Function for CHST9 Gene

Molecular function for CHST9 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.

Enzyme Numbers (IUBMB) for CHST9 Gene

Gene Ontology (GO) - Molecular Function for CHST9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity ISS --
GO:0008146 sulfotransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0047756 chondroitin 4-sulfotransferase activity TAS --
genes like me logo Genes that share ontologies with CHST9: view
genes like me logo Genes that share phenotypes with CHST9: view

Animal Model Products

miRNA for CHST9 Gene

miRTarBase miRNAs that target CHST9

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHST9 Gene

Localization for CHST9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST9 Gene

Isoform 1: Golgi apparatus membrane; Single-pass type II membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHST9 gene
Compartment Confidence
golgi apparatus 5
extracellular 4
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHST9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11139592
genes like me logo Genes that share ontologies with CHST9: view

Pathways & Interactions for CHST9 Gene

genes like me logo Genes that share pathways with CHST9: view

Pathways by source for CHST9 Gene

Interacting Proteins for CHST9 Gene

Selected Interacting proteins: Q7L1S5-CHST9_HUMAN for CHST9 Gene via IID

Gene Ontology (GO) - Biological Process for CHST9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006790 sulfur compound metabolic process IDA 11445554
GO:0016051 carbohydrate biosynthetic process IEA --
GO:0030166 proteoglycan biosynthetic process ISS --
GO:0030203 glycosaminoglycan metabolic process NAS 11139592
genes like me logo Genes that share ontologies with CHST9: view

No data available for SIGNOR curated interactions for CHST9 Gene

Transcripts for CHST9 Gene

Unigene Clusters for CHST9 Gene

Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST9 Gene

No ASD Table

Relevant External Links for CHST9 Gene

GeneLoc Exon Structure for
CHST9
ECgene alternative splicing isoforms for
CHST9

Expression for CHST9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHST9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST9 Gene

This gene is overexpressed in Minor Salivary Gland (x10.5).

Protein differential expression in normal tissues from HIPED for CHST9 Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHST9 Gene



Protein tissue co-expression partners for CHST9 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHST9 Gene:

CHST9

SOURCE GeneReport for Unigene cluster for CHST9 Gene:

Hs.44584

mRNA Expression by UniProt/SwissProt for CHST9 Gene:

Q7L1S5-CHST9_HUMAN
Tissue specificity: Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland. Weakly or not expressed in heart, liver and spinal cord.
genes like me logo Genes that share expression patterns with CHST9: view

Primer Products

Orthologs for CHST9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST9 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia CHST9 34 35
  • 89.74 (n)
cow
(Bos Taurus)
Mammalia CHST9 34 35
  • 86.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHST9 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chst9 34 16 35
  • 80.91 (n)
rat
(Rattus norvegicus)
Mammalia Chst9 34
  • 80.55 (n)
oppossum
(Monodelphis domestica)
Mammalia CHST9 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHST9 34 35
  • 67.81 (n)
lizard
(Anolis carolinensis)
Reptilia CHST9 35
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13937 35
  • 23 (a)
ManyToMany
CG14024 35
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
Species where no ortholog for CHST9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CHST9 Gene

ENSEMBL:
Gene Tree for CHST9 (if available)
TreeFam:
Gene Tree for CHST9 (if available)

Paralogs for CHST9 Gene

Paralogs for CHST9 Gene

(5) SIMAP similar genes for CHST9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHST9: view

Variants for CHST9 Gene

Sequence variations from dbSNP and Humsavar for CHST9 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1025655 -- 27,016,247(-) CTGGT(C/T)ATGCT intron-variant
rs1036459 -- 27,032,500(-) aagga(C/G)ggagg intron-variant
rs10438990 -- 26,965,659(+) AGACT(A/G)AATGA intron-variant
rs10460045 -- 26,975,735(+) tatat(A/G)tatat intron-variant
rs10460098 -- 26,975,737(+) tatat(A/G)tatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST9 Gene

Variant ID Type Subtype PubMed ID
nsv978623 CNV duplication 23825009
nsv962502 CNV duplication 23825009
nsv954932 CNV deletion 24416366
nsv833600 CNV gain 17160897
nsv820910 CNV deletion 20802225
nsv576588 CNV loss 21841781
nsv528945 CNV loss 19592680
nsv512523 CNV loss 21212237
nsv475202 CNV novel sequence insertion 20440878
nsv2236 CNV insertion 18451855
nsv1116264 CNV deletion 24896259
esv3893079 CNV gain 25118596
esv3642035 CNV gain 21293372
esv3642033 CNV loss 21293372
esv3642032 CNV loss 21293372
esv3642031 CNV loss 21293372
esv3642030 CNV gain 21293372
esv3642029 CNV loss 21293372
esv3582991 CNV loss 25503493
esv3555154 CNV deletion 23714750
esv3435383 CNV insertion 20981092
esv3134901 CNV deletion 24192839
esv2761995 CNV loss 21179565
esv2716889 CNV deletion 23290073
esv2716888 CNV deletion 23290073
esv2676360 CNV deletion 23128226
esv2668079 CNV deletion 23128226
esv2658895 CNV deletion 23128226
esv25443 CNV gain 19812545
esv1411247 CNV insertion 17803354
dgv9e198 CNV loss 23635498
dgv5876n54 CNV loss 21841781
dgv1570n106 CNV deletion 24896259
dgv1569n106 CNV deletion 24896259
dgv10e198 CNV loss 23635498

Variation tolerance for CHST9 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHST9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHST9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST9 Gene

Disorders for CHST9 Gene

Relevant External Links for CHST9

Genetic Association Database (GAD)
CHST9
Human Genome Epidemiology (HuGE) Navigator
CHST9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHST9

No disorders were found for CHST9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHST9 Gene

Publications for CHST9 Gene

  1. Molecular cloning and expression of an N-acetylgalactosamine-4-O- sulfotransferase that transfers sulfate to terminal and non-terminal beta 1,4-linked N-acetylgalactosamine. (PMID: 11139592) Kang H.-G. … Schachner M. (J. Biol. Chem. 2001) 2 3 4 64
  2. Molecular cloning and expression of two distinct human N- acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1->4GlcNAc beta 1->R in both N- and O-glycans. (PMID: 11445554) Hiraoka N. … Fukuda M. (Glycobiology 2001) 2 3 4 64
  3. Examination of copy number variations of CHST9 in multiple types of hematologic malignancies. (PMID: 21156230) Zhao X. … Wan J. (Cancer Genet. Cytogenet. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CHST9 Gene

Sources for CHST9 Gene

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