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Aliases for CHST8 Gene

Aliases for CHST8 Gene

  • Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 8 2 3
  • N-Acetylgalactosamine-4-O-Sulfotransferase 1 3 4
  • GalNAc-4-O-Sulfotransferase 1 3 4
  • GALNAC-4-ST1 3 4
  • GalNAc4ST-1 3 4
  • GALNAC4ST1 3 6
  • Carbohydrate Sulfotransferase 8 3
  • EC 2.8.2.- 4
  • GalNAc4ST 3
  • PSS3 3

External Ids for CHST8 Gene

Previous GeneCards Identifiers for CHST8 Gene

  • GC19P034730
  • GC19P034561
  • GC19P038788
  • GC19P038804
  • GC19P038867
  • GC19P034112
  • GC19P030612

Summaries for CHST8 Gene

Entrez Gene Summary for CHST8 Gene

  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST8 Gene

CHST8 (Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 8) is a Protein Coding gene. Diseases associated with CHST8 include peeling skin syndrome type a and peeling skin syndrome. Among its related pathways are Biological oxidations. GO annotations related to this gene include N-acetylgalactosamine 4-O-sulfotransferase activity. An important paralog of this gene is CHST13.

UniProtKB/Swiss-Prot for CHST8 Gene

  • Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST8 Gene

Genomics for CHST8 Gene

Regulatory Elements for CHST8 Gene

Genomic Location for CHST8 Gene

Start:
33,621,955 bp from pter
End:
33,773,509 bp from pter
Size:
151,555 bases
Orientation:
Plus strand

Genomic View for CHST8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHST8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST8 Gene

Proteins for CHST8 Gene

  • Protein details for CHST8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2A9-CHST8_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 8
    Protein Accession:
    Q9H2A9
    Secondary Accessions:
    • Q9H3N2

    Protein attributes for CHST8 Gene

    Size:
    424 amino acids
    Molecular mass:
    48834 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHST8 Gene

Proteomics data for CHST8 Gene at MOPED

Post-translational modifications for CHST8 Gene

  • Glycosylation at Thr76, Ser80, Ser81, Asn128, Asn294, Asn367, and Asn415
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST8 Gene

No data available for DME Specific Peptides for CHST8 Gene

Domains for CHST8 Gene

Gene Families for CHST8 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for CHST8 Gene

Suggested Antigen Peptide Sequences for CHST8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2A9

UniProtKB/Swiss-Prot:

CHST8_HUMAN :
  • Q9H2A9
Family:
  • Belongs to the sulfotransferase 2 family.
genes like me logo Genes that share domains with CHST8: view

Function for CHST8 Gene

Molecular function for CHST8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=10 uM for carbonic anhydrase VI {ECO:0000269 PubMed:11001942}; pH dependence: Optimum pH is 7.2. {ECO:0000269 PubMed:11001942};
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.
UniProtKB/Swiss-Prot Induction: Down-regulated (17-fold) in prion-infected cells.

Enzyme Numbers (IUBMB) for CHST8 Gene

Gene Ontology (GO) - Molecular Function for CHST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity IDA 10988300
GO:0008146 sulfotransferase activity --
genes like me logo Genes that share ontologies with CHST8: view
genes like me logo Genes that share phenotypes with CHST8: view

Animal Models for CHST8 Gene

MGI Knock Outs for CHST8:

miRNA for CHST8 Gene

miRTarBase miRNAs that target CHST8

No data available for Transcription Factor Targeting and HOMER Transcription for CHST8 Gene

Localization for CHST8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST8 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST8 Gene COMPARTMENTS Subcellular localization image for CHST8 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CHST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane NAS 10988300
genes like me logo Genes that share ontologies with CHST8: view

Pathways for CHST8 Gene

SuperPathways for CHST8 Gene

Superpath Contained pathways
1 Biological oxidations
genes like me logo Genes that share pathways with CHST8: view

Pathways by source for CHST8 Gene

1 BioSystems pathway for CHST8 Gene

Interacting Proteins for CHST8 Gene

Gene Ontology (GO) - Biological Process for CHST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006790 sulfur compound metabolic process IDA 11445554
GO:0007417 central nervous system development NAS 10988300
GO:0016051 carbohydrate biosynthetic process IEA --
GO:0030166 proteoglycan biosynthetic process IDA 10988300
GO:0042446 hormone biosynthetic process IEP 10988300
genes like me logo Genes that share ontologies with CHST8: view

Transcripts for CHST8 Gene

Unigene Clusters for CHST8 Gene

Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHST8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for CHST8 Gene

GeneLoc Exon Structure for
CHST8
ECgene alternative splicing isoforms for
CHST8

Expression for CHST8 Gene

mRNA expression in normal human tissues for CHST8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST8 Gene

This gene is overexpressed in Pituitary (19.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CHST8 Gene

SOURCE GeneReport for Unigene cluster for CHST8 Gene Hs.165724

mRNA Expression by UniProt/SwissProt for CHST8 Gene

Q9H2A9-CHST8_HUMAN
Tissue specificity: Predominantly expressed in pituitary gland. In brain, it is expressed in pituitary gland, cerebellum, medulla oblongata, pons, thalamus and spinal cord. Expressed in the epidermis. Expressed at lower level in lung, spleen, adrenal gland, placenta, prostate, testis, mammary gland and trachea.
genes like me logo Genes that share expressions with CHST8: view

Orthologs for CHST8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST8 35
  • 99.37 (n)
  • 99.29 (a)
CHST8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHST8 35
  • 87.74 (n)
  • 87.74 (a)
CHST8 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHST8 35
  • 88.29 (n)
  • 88.21 (a)
CHST8 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chst8 35
  • 83.09 (n)
  • 87.5 (a)
Chst8 16
Chst8 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHST8 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chst8 35
  • 83.89 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves CHST8 35
  • 66.34 (n)
  • 74.84 (a)
CHST8 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST8 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chst8 35
  • 61.18 (n)
  • 64.41 (a)
zebrafish
(Danio rerio)
Actinopterygii chst8 35
  • 64.58 (n)
  • 69.37 (a)
chst8 36
  • 59 (a)
OneToMany
CHST8 (2 of 2) 36
  • 71 (a)
OneToMany
wufj18f04 35
fruit fly
(Drosophila melanogaster)
Insecta CG13937 36
  • 22 (a)
ManyToMany
CG14024 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
Species with no ortholog for CHST8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST8 Gene

ENSEMBL:
Gene Tree for CHST8 (if available)
TreeFam:
Gene Tree for CHST8 (if available)

Paralogs for CHST8 Gene

Paralogs for CHST8 Gene

Selected SIMAP similar genes for CHST8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHST8: view

Variants for CHST8 Gene

Sequence variations from dbSNP and Humsavar for CHST8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs108295 -- 33,733,911(+) CTTCC(A/G)TCGTT intron-variant
rs110777 -- 33,762,044(-) GGAAA(C/T)GCACC intron-variant
rs157725 -- 33,717,696(+) ggatg(C/T)taatg intron-variant
rs157726 -- 33,717,318(+) TAGCC(A/G)GGCGT intron-variant
rs157727 -- 33,716,650(+) gatgt(A/G)agcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST8 Gene

Variant ID Type Subtype PubMed ID
dgv1073e1 CNV Complex 17122850
dgv139e55 CNV Gain 17911159
esv23382 CNV Loss 19812545
esv2718477 CNV Deletion 23290073
nsv509736 CNV Insertion 20534489
nsv833809 CNV Loss 17160897
essv22276 CNV CNV 17122850
nsv507894 CNV Insertion 20534489
esv2718478 CNV Deletion 23290073
esv1416262 CNV Deletion 17803354
esv2718479 CNV Deletion 23290073
esv1700346 CNV Insertion 17803354
esv33416 CNV Loss 17666407

Relevant External Links for CHST8 Gene

HapMap Linkage Disequilibrium report
CHST8
Human Gene Mutation Database (HGMD)
CHST8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST8 Gene

Disorders for CHST8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CHST8 Gene including...

Search for CHST8 Gene in MalaCards »

UniProtKB/Swiss-Prot

CHST8_HUMAN
  • Note=CHST8 mutations may be a cause of generalized non-inflammatory peeling skin syndrome type A (PubMed:22289416). Peeling skin syndrome (PSS) is a genodermatosis characterized by continuous shedding of the outer layers of the epidermis. Two main PSS subtypes have been suggested. Patients with non-inflammatory PSS (type A) manifest white scaling, with painless and easy removal of the skin, irritation when in contact with water, dust and sand, and no history of erythema, pruritis or atopy. Inflammatory PSS (type B) is associated with generalized erythema, pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly after. Several patients have been reported with high IgE levels. {ECO:0000269 PubMed:22289416}.

(1) University of Copenhagen DISEASES for CHST8 Gene

Relevant External Links for CHST8

Genetic Association Database (GAD)
CHST8
Human Genome Epidemiology (HuGE) Navigator
CHST8
genes like me logo Genes that share disorders with CHST8: view

Publications for CHST8 Gene

  1. Molecular cloning and expression of the pituitary glycoprotein hormone N-acetylgalactosamine-4-O-sulfotransferase. (PMID: 10988300) Xia G. … Baenziger J.U. (J. Biol. Chem. 2000) 2 3 4
  2. Molecular cloning and characterization of GalNAc 4-sulfotransferase expressed in human pituitary gland. (PMID: 11001942) Okuda T. … Habuchi O. (J. Biol. Chem. 2000) 2 3 4
  3. Molecular cloning and expression of two distinct human N- acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1->4GlcNAc beta 1->R in both N- and O-glycans. (PMID: 11445554) Hiraoka N. … Fukuda M. (Glycobiology 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Glycosylation-related gene expression in prion diseases: PrPSc accumulation in scrapie infected GT1 cells depends on beta-1,4-linked GalNAc-4-SO4 hyposulfation. (PMID: 15632154) Barret A. … Gallet P.F. (J. Biol. Chem. 2005) 3 4

Products for CHST8 Gene

Sources for CHST8 Gene

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