Aliases for CHST8 Gene
External Ids for CHST8 Gene
Previous GeneCards Identifiers for CHST8 Gene
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for CHST8 Gene
CHST8 (Carbohydrate Sulfotransferase 8) is a Protein Coding gene. Diseases associated with CHST8 include Peeling Skin Syndrome 3 and Peeling Skin Syndrome. Among its related pathways are N-glycan antennae elongation in the medial/trans-Golgi and Transport to the Golgi and subsequent modification. GO annotations related to this gene include sulfotransferase activity and N-acetylgalactosamine 4-O-sulfotransferase activity. An important paralog of this gene is CHST9.
UniProtKB/Swiss-Prot for CHST8 Gene
Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.