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CHST7 Gene(Protein Coding)

Carbohydrate Sulfotransferase 7

GCID:
GC0XP046574
GIFtS:
52
Genes Participants
UDN Logo

Aliases for CHST7 Gene

Aliases for CHST7 Gene

  • Carbohydrate Sulfotransferase 7 2 3 5
  • Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 5 3 4
  • Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 7 2 3
  • N-Acetylglucosamine 6-O-Sulfotransferase 4 3 4
  • GlcNAc6ST-4 3 4
  • Gn6st-4 3 4
  • C6ST-2 3 4
  • GST-5 3 4
  • Chondroitin 6-Sulfotransferase-2 3
  • Chondroitin 6-Sulfotransferase 2 4
  • EC 2.8.2.17 4
  • EC 2.8.2.- 4

External Ids for CHST7 Gene

Previous GeneCards Identifiers for CHST7 Gene

  • GC0XP045236
  • GC0XP044693
  • GC0XP045479
  • GC0XP046189
  • GC0XP046318
  • GC0XP046433
  • GC0XP044144

Summaries for CHST7 Gene

Entrez Gene Summary for CHST7 Gene

  • This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013]

GeneCards Summary for CHST7 Gene

CHST7 (Carbohydrate Sulfotransferase 7) is a Protein Coding gene. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and chondroitin 6-sulfotransferase activity. An important paralog of this gene is CHST2.

UniProtKB/Swiss-Prot for CHST7 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.

Gene Wiki entry for CHST7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST7 Gene

Genomics for CHST7 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CHST7 Gene

Enhancers for CHST7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG046625 1.5 FANTOM5 Ensembl ENCODE 34.9 +54.4 54362 4.5 PKNOX1 FOXA2 TBL1XR1 FEZF1 ZBTB40 SCRT2 RELB ETV6 FOS IKZF2 CHST7 SLC9A7 RP2 ZNF674 PGAM1P7 PIR58897
GH0XG046572 1.3 FANTOM5 ENCODE 27.3 +0.6 589 4.4 HDGF PKNOX1 WRNIP1 ARID4B SIN3A BRCA1 GLIS2 SP3 REST TBX21 CHST7 SLC9A7 RP2 ZNF674 PIR58897
GH0XG046577 0.9 FANTOM5 ENCODE 23.2 +3.8 3797 0.5 ZNF341 ZNF266 CEBPG ZXDB NFE2L2 CHST7 RP2 ZNF674 PIR58897
GH0XG046791 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.2 +219.1 219109 3.4 BMI1 BRCA1 RAD21 ZBTB40 YY1 ETV6 FOS RELB CREM IKZF2 RP2 CHST7 SLC9A7 ZNF674
GH0XG046704 1.2 FANTOM5 ENCODE 11.9 +131.3 131288 1.9 HDGF TBP TBL1XR1 BMI1 TCF12 EGR1 ZNF143 RELB ETV6 IKZF2 CHST7 YBX1P8 LOC100420317
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHST7 on UCSC Golden Path with GeneCards custom track

Promoters for CHST7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246338 1513 4001 PKNOX1 ARID4B SIN3A BRCA1 RAD21 GLIS2 ZNF366 EGR2 ZNF654 SP3

Transcription factor binding sites by QIAGEN in the CHST7 gene promoter:

Genomic Location for CHST7 Gene

Chromosome:
X
Start:
46,573,687 bp from pter
End:
46,598,496 bp from pter
Size:
24,810 bases
Orientation:
Plus strand

Genomic View for CHST7 Gene

Genes around CHST7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHST7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHST7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CHST7 Gene

Proteins for CHST7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CHST7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS84-CHST7_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 7
    Protein Accession:
    Q9NS84
    Secondary Accessions:
    • O75667

    Protein attributes for CHST7 Gene

    Size:
    486 amino acids
    Molecular mass:
    54266 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHST7 Gene

Protein Expression for CHST7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CHST7 Gene

  • Ubiquitination at Lys272
  • Glycosylation at posLast=8888, Asn186, and Asn407
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHST7 Gene

Domains & Families for CHST7 Gene

Gene Families for CHST7 Gene

HGNC:

Protein Domains for CHST7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHST7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS84

UniProtKB/Swiss-Prot:

CHST7_HUMAN :
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Family:
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
genes like me logo Genes that share domains with CHST7: view

Function for CHST7 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CHST7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + chondroitin = adenosine 3,5-bisphosphate + chondroitin 6-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.

Enzyme Numbers (IUBMB) for CHST7 Gene

Gene Ontology (GO) - Molecular Function for CHST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity IDA 10913333
GO:0008146 sulfotransferase activity IEA --
GO:0008459 chondroitin 6-sulfotransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CHST7: view

Phenotypes for CHST7 Gene

GenomeRNAi human phenotypes for CHST7:
genes like me logo Genes that share phenotypes with CHST7: view

Animal Model Products

CRISPR Products

miRNA for CHST7 Gene

miRTarBase miRNAs that target CHST7

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHST7 Gene

Localization for CHST7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST7 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHST7 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 10781596
genes like me logo Genes that share ontologies with CHST7: view

Pathways & Interactions for CHST7 Gene

genes like me logo Genes that share pathways with CHST7: view

Gene Ontology (GO) - Biological Process for CHST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005976 polysaccharide metabolic process TAS 10781596
GO:0006044 N-acetylglucosamine metabolic process IDA 10913333
GO:0006790 sulfur compound metabolic process IDA 10913333
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHST7: view

No data available for SIGNOR curated interactions for CHST7 Gene

Drugs & Compounds for CHST7 Gene

Products:

  1. Drug

(1) Drugs for CHST7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chondroitin Nutra 44

(7) Additional Compounds for CHST7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
 1053-73-2
Chondroitin 6'-sulfate
Keratan
  • Keratan 6'-sulfate
  • Keratan 6'-sulphate
  • Keratan sulfate
  • Keratan sulphate
  • Kerato 6'-sulfate
 69992-87-6
n-acetyllactosamine
  • beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • beta-D-Galactosyl-1,4-N-acetyl-D-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-beta-delta-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-delta-glucosamine
  • D-Galactopyranosyl
 32181-59-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
 482-67-7
genes like me logo Genes that share compounds with CHST7: view

Transcripts for CHST7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CHST7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(61) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHST7 Gene

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST7 Gene

No ASD Table

Relevant External Links for CHST7 Gene

GeneLoc Exon Structure for
CHST7
ECgene alternative splicing isoforms for
CHST7

Expression for CHST7 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHST7 Gene

mRNA expression in normal human tissues for CHST7 Gene
mRNA expression by BioGPS for CHST7 GenemRNA expression by GTEx for CHST7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST7 Gene

This gene is overexpressed in Ovary (x5.3).

Protein differential expression in normal tissues from HIPED for CHST7 Gene

This gene is overexpressed in Ovary (40.3) and Testis (28.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHST7 Gene



Protein tissue co-expression partners for CHST7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHST7 Gene:

CHST7

SOURCE GeneReport for Unigene cluster for CHST7 Gene:

Hs.129955

mRNA Expression by UniProt/SwissProt for CHST7 Gene:

Q9NS84-CHST7_HUMAN
Tissue specificity: Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin.

Evidence on tissue expression from TISSUES for CHST7 Gene

  • Nervous system(4.4)
  • Liver(4.1)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with CHST7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CHST7 Gene

Orthologs for CHST7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST7 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia CHST7 34 35
  • 90.95 (n)
cow
(Bos Taurus)
 Mammalia CHST7 34 35
  • 88.89 (n)
rat
(Rattus norvegicus)
 Mammalia Chst7 34
  • 85.22 (n)
mouse
(Mus musculus)
 Mammalia Chst7 34 16 35
  • 84.16 (n)
oppossum
(Monodelphis domestica)
 Mammalia CHST7 35
  • 74 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 32 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia chst7 34
  • 62.23 (n)
Str.16127 34
zebrafish
(Danio rerio)
 Actinopterygii LOC563748 34
  • 60.34 (n)
CHST7 35
  • 53 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG9550 35
  • 21 (a)
 ManyToMany
CG31637 35
  • 18 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 33 (a)
 ManyToMany
-- 35
  • 26 (a)
 ManyToMany
-- 35
  • 24 (a)
 ManyToMany
-- 35
  • 24 (a)
 ManyToMany
-- 35
  • 22 (a)
 ManyToMany
-- 35
  • 20 (a)
 ManyToMany
CSA.5535 35
  • 19 (a)
 ManyToMany
-- 35
  • 18 (a)
 ManyToMany
Species where no ortholog for CHST7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST7 Gene

ENSEMBL:
Gene Tree for CHST7 (if available)
TreeFam:
Gene Tree for CHST7 (if available)

Paralogs for CHST7 Gene

Paralogs for CHST7 Gene

(4) SIMAP similar genes for CHST7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHST7: view

Variants for CHST7 Gene

Sequence variations from dbSNP and Humsavar for CHST7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000004642 -- 46,582,467(+) GAAAA(C/T)TCTTG intron-variant
rs1000323288 -- 46,574,795(+) CGCCT(C/G)AAGTC reference, synonymous-codon
rs1000483927 -- 46,585,100(+) AATAC(A/G)CAGAT intron-variant
rs1000738310 -- 46,590,395(+) AACAT(A/G)AGGGC intron-variant
rs1001000422 -- 46,596,213(+) TTTAT(G/T)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST7 Gene

Variant ID Type Subtype PubMed ID
esv25002 CNV loss 19812545
esv3576853 CNV gain 25503493

Variation tolerance for CHST7 Gene

Gene Damage Index Score: 0.98; 20.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHST7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHST7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST7 Gene

Disorders for CHST7 Gene

Relevant External Links for CHST7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHST7

No disorders were found for CHST7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHST7 Gene

Publications for CHST7 Gene

  1. Molecular cloning and expression of a novel chondroitin 6-O- sulfotransferase. (PMID: 10781596) Kitagawa H. … Sugahara K. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5). (PMID: 10956661) Bhakta S. … Hemmerich S. (J. Biol. Chem. 2000) 3 4 22 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CHST7 Gene

Sources for CHST7 Gene

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