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CHST7 Gene

protein-coding   GIFtS: 55
GCID: GC0XP046433

Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 71 2     gn6st-42
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 52 3     EC 2.8.2.-3
C6ST-22 3     EC 2.8.2.173
GST-52 3     GlcNAc6ST-43
N-Acetylglucosamine 6-O-Sulfotransferase 42 3     Gn6st-43
Carbohydrate Sulfotransferase 72     Chondroitin 6-Sulfotransferase 23
Chondroitin 6-Sulfotransferase-22     C6ST25
glcNAc6ST-42     

External Ids:    HGNC: 138171   Entrez Gene: 565482   Ensembl: ENSG000001471197   OMIM: 3003755   UniProtKB: Q9NS843   

Export aliases for CHST7 gene to outside databases

Previous GC identifers: GC0XP045236 GC0XP044693 GC0XP045479 GC0XP046189 GC0XP046318 GC0XP044144


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHST7 Gene:
This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine)
6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of
sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the
sulfation of 6-hydroxyl group of GalNAc in chondroitin. (provided by RefSeq, Aug 2013)

GeneCards Summary for CHST7 Gene:
CHST7 (carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7) is a protein-coding gene. Diseases associated with CHST7 include sly syndrome, and morquio syndrome b. GO annotations related to this gene include chondroitin 6-sulfotransferase activity and N-acetylglucosamine 6-O-sulfotransferase activity. An important paralog of this gene is CHST4.

UniProtKB/Swiss-Prot: CHST7_HUMAN, Q9NS84
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on
mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine
(GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer
with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the
Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc

Gene Wiki entry for CHST7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHST7 gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST7 promoter sequence
   Search Chromatin IP Primers for CHST7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHST7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3

CHST7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST7 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP046433:  view genomic region     (about GC identifiers)

Start:
46,433,192 bp from pter      End:
46,457,843 bp from pter
Size:
24,652 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CHST7_HUMAN, Q9NS84 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 7  
Size: 486 amino acids; 54266 Da
Secondary accessions: O75667

Explore the universe of human proteins at neXtProt for CHST7: NX_Q9NS84

Explore proteomics data for CHST7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys272
  • Glycosylation2 at Asn88, Asn186, Asn407
  • Modification sites at PhosphoSitePlus

  • See CHST7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_063939.2  
    ENSEMBL proteins: 
     ENSP00000276055  
    Reactome Protein details: Q9NS84

    CHST7 Human Recombinant Protein Products:

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    CHST7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for CHST7

    CHST7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for CHST7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR016469 Carbohydrate_sulfotransferase
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9NS84

    ProtoNet protein and cluster: Q9NS84

    UniProtKB/Swiss-Prot: CHST7_HUMAN, Q9NS84
    Similarity: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily


    CHST7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHST7_HUMAN, Q9NS84
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on
    mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine
    (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer
    with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the
    Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc
    Catalytic activity: 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin
    6'-sulfate

         Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.2.171

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001517N-acetylglucosamine 6-O-sulfotransferase activity IDA10913333
    GO:0008146sulfotransferase activity ----
    GO:0008459chondroitin 6-sulfotransferase activity IDA10781596
         
    CHST7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHST7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHST7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHST7:
    hsa-mir-26b-5p (MIRT029511)

    Block miRNA regulation of human, mouse, rat CHST7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST7 (see all 17):
    hsa-miR-328 hsa-miR-25 hsa-miR-1255a hsa-miR-23a hsa-miR-92b hsa-miR-203 hsa-miR-653 hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidCHST7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHST7
    Predesigned siRNA for gene silencing in human, mouse, rat CHST7

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CHST7 (NM_019886)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CHST7 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHST7_HUMAN, Q9NS84: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum1
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane TAS10781596

    CHST7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHST7 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.00
    Chondroitin sulfate biosynthesis0.41
    3Biological oxidations
    metapathway biotransformation0.42
    4Metabolism
    Metabolism0.38
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CHST7
        Articular Cartilage Extracellular Matrix


    3 BioSystems Pathways for CHST7
        chondroitin sulfate biosynthesis (late stages)
    metapathway biotransformation
    chondroitin sulfate biosynthesis

    1 Reactome Pathway for CHST7
        Chondroitin sulfate biosynthesis


    1 Kegg Pathway  (Kegg details for CHST7):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate


    CHST7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CHST7: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CHST7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for CHST7 (ENSP000002760554) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHPFENSP000002437764STRING: ENSP00000243776
    CHST11ENSP000003057254STRING: ENSP00000305725
    CHST12ENSP000002587114STRING: ENSP00000258711
    CHST13ENSP000003174044STRING: ENSP00000317404
    CHSY1ENSP000002541904STRING: ENSP00000254190
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0005976polysaccharide metabolic process TAS10781596
    GO:0006044N-acetylglucosamine metabolic process IDA10913333
    GO:0006790sulfur compound metabolic process IDA10913333
    GO:0030203glycosaminoglycan metabolic process TAS--

    CHST7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHST7

    5 HMDB Compounds for CHST7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    KeratanKerato sulfate (see all 4)69992-87-6--
    N-AcetyllactosamineD-galactopyranosyl (see all 8)32181-59-2--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    3 Novoseek inferred chemical compound relationships for CHST7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 77 6 10781596 (2), 10956661 (2)
    n-acetylglucosamine 64.8 2 10956661 (1)
    sulfate 52 1 10781596 (1)



    CHST7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHST7 gene: 
    NM_019886.3  

    Unigene Cluster for CHST7:

    Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
    Hs.129955  [show with all ESTs]
    Unigene Representative Sequence: NM_019886
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000276055(uc004dgt.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat CHST7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST7 (see all 17):
    hsa-miR-328 hsa-miR-25 hsa-miR-1255a hsa-miR-23a hsa-miR-92b hsa-miR-203 hsa-miR-653 hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidCHST7 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST7
      QuantiTect SYBR Green Assays in human, mouse, rat CHST7
      QuantiFast Probe-based Assays in human, mouse, rat CHST7

    Additional mRNA sequence: 

    AB037187.1 AB040711.1 BC023971.1 BC045537.1 

    1 DOTS entry:

    DT.40113200 

    Selected AceView cDNA sequences (see all 61):

    BX281121 BC045537 BC023971 AB037187 NM_019886 BU856499 BE672928 BQ940898 
    AB040711 CR619110 CF132427 BE855857 BQ892599 CK903413 AA229836 CK903414 
    BQ447392 BM717972 BQ690181 BG719079 BF061000 BX383479 BI753579 BM006567 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHST7 expression in normal human tissues (normalized intensities)      CHST7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATGAAAA
    CHST7 Expression
    About this image


    CHST7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Arteries
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
     
     Ovary (Reproductive System)
    CHST7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHST7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129955

    UniProtKB/Swiss-Prot: CHST7_HUMAN, Q9NS84
    Tissue specificity: Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level
    in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin

        Pathway & Disease-focused RT2 Profiler PCR Array including CHST7: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHST7
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST7
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    QuantiFast Probe-based Assays in human, mouse, rat CHST7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHST7 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst71 , 5 carbohydrate (N-acetylglucosamino) sulfotransferase more1, 5 84.16(n)1
    87.81(a)1
      X (15.50 cM)5
    603221  NM_021715.11  NP_068361.11 
     200595605 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    many ↔ many
    2(192755869-192757653)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.161272 Transcribed sequence with weak similarity to protein more 72.97(n)    AL853506.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5637481 carbohydrate sulfotransferase 7-like 60.34(n)
    56.95(a)
      563748  XM_005165997.1  XP_005166054.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95506
    CG316376
    --
    21(a)
    18(a)
    many ↔ many
    many ↔ many
    2L(6497053-6498455)
    2L(6498642-6526996)


    ENSEMBL Gene Tree for CHST7 (if available)
    TreeFam Gene Tree for CHST7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHST7 gene
    CHST42  CHST12  CHST22  CHST32  CHST62  CHST52  
    4 SIMAP similar genes for CHST7 using alignment to 2 protein entries:     CHST7_HUMAN (see all proteins):
    CHST2    CHST4    CHST5    CHST6

    CHST7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHST7 (see all 309)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845187811,2
    --46350159(+) GTCTCA/GGCTGC 1 -- us2k10--------
    rs1890316091,2
    --46350546(+) TGGAAA/CTGGAG 1 -- us2k10--------
    rs1410440191,2
    C--46350612(+) TATGAA/GGTTAT 1 -- us2k10--------
    rs1930452691,2
    --46350800(+) GAGTTC/TAGCTT 1 -- us2k10--------
    rs2009596741,2
    C--46350934(+) GGCTG-/AAGAAG 1 -- us2k10--------
    rs1851180581,2
    --46351626(+) TGCCAC/GGTACA 1 -- us2k10--------
    rs1899598691,2
    --46351836(+) TGCCTA/GAAGTC 1 -- us2k10--------
    rs1812686291,2
    C--46351918(+) CCCGCC/TACAGC 1 -- us2k10--------
    rs1854787621,2
    C--46352021(+) CTGCTA/GAGCCG 1 -- us2k10--------
    rs615754621,2
    C,F--46352275(+) CTGTAC/TACGCT 2 Y syn17Minor allele frequency- T:0.03NS MN WA EA NA 4060

    HapMap Linkage Disequilibrium report for CHST7 (46433192 - 46457843 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CHST7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv25002CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHST7
    DNA2.0 Custom Variant and Variant Library Synthesis for CHST7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300375    OMIM disorders: --

    4 diseases for CHST7:    About MalaCards
    sly syndrome    morquio syndrome b    mucopolysaccharidoses    thyroiditis


    CHST7 for disorders           About GeneDecksing


    Export disorders for CHST7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHST7 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CHST7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a novel chondroitin 6-O- sulfotransferase. (PubMed id 10781596)1, 2, 3, 9 Kitagawa H.... Sugahara K. (J. Biol. Chem. 2000)
    2. Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5). (PubMed id 10956661)1, 2, 9 Bhakta S.... Hemmerich S. (J. Biol. Chem. 2000)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities. (PubMed id 10913333)1, 2 Uchimura K.... Muramatsu T. (Biochem. Biophys. Res. Commun. 2000)
    7. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PubMed id 11944989)1, 9 Thiselton D.L.... Meindl A. (Genomics 2002)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56548 HGNC: 13817 AceView: CHST7 Ensembl:ENSG00000147119 euGenes: HUgn56548
    ECgene: CHST7 Kegg: 56548 H-InvDB: CHST7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CHST7 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=CHST7

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHST7 gene:
    Search GeneIP for patents involving CHST7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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