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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHST6 Gene

protein-coding   GIFtS: 56
GCID: GC16M075508

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase...


(Previous symbol: MCDC1)
 Explore 12 diseases affiliated with
CHST6 via our new
 Human Malady Compendium 
Biological research products
for CHST6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 61 2     Corneal N-Acetylglucosamine 6-Sulfotransferase2
MCDC11 2 5     GlcNAc6ST-53
Corneal N-Acetylglucosamine-6-O-Sulfotransferase2 3     Gn6st-53
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 4-Beta2 3     EC 2.8.2.-3
C-GlcNAc6ST2 3     GlcNAc6ST-53
GST4-Beta1     Gn6st-53
HCGn6ST1     EC 2.8.28
N-Acetylglucosamine 6-O-Sulfotransferase 52 3     EC 2.8.2.178
Carbohydrate Sulfotransferase 62     EC 2.8.2.218

External Ids:    HGNC: 69381   Entrez Gene: 41662   Ensembl: ENSG000001831967   OMIM: 6052945   UniProtKB: Q9GZX33   

Export aliases for CHST6 gene to outside databases

Previous GC identifers: GC16M066440 GC16M076471 GC16M075245 GC16M075286 GC16M074064 GC16M061258


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHST6:
The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of
keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal
dystrophy (MCD). (provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: CHST6_HUMAN, Q9GZX3
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation
of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the
non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures

Gene Wiki entry for CHST6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHST6 gene promoter:
         AREB6   NF-1/L   NF-1   AML1a   NF-kappaB1   NF-kappaB   NF-E2   NF-E2 p45   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHST6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22

CHST6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M075508:  view genomic region     (about GC identifiers)

Start:
75,507,022 bp from pter      End:
75,529,282 bp from pter
Size:
22,261 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHST6_HUMAN, Q9GZX3 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 6  
Size: 395 amino acids; 44099 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Caution: PubMed:12824236 reported a Gly-204 variant, however according to their results reported in figure 1, it is a
Gln-204 variant
Secondary accessions: D3DUK3

Explore the universe of human proteins at neXtProt for CHST6: NX_Q9GZX3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9GZX3

  • 4/5 DME Specific Peptides for CHST6 (Q9GZX3) (see all 5)
     LVRDPRAV  LHMAVRDL  VVLKEVRF  RSGSSFVGQLF 

    CHST6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_067628.1  
    ENSEMBL proteins: 
     ENSP00000328983   ENSP00000375079  
    Reactome Protein details: Q9GZX3
    Human Recombinant Protein Products: 
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    Novus Biologicals CHST6 Protein
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    Browse Sino Biological Recombinant Proteins
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    Uscn Proteins for CHST6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus TAS11181564
    GO:0016021integral to membrane IEA--


    CHST6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CHST6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR016469 Carbohydrate_sulfotransferase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZX3

    ProtoNet protein and cluster: Q9GZX3

    UniProtKB/Swiss-Prot: CHST6_HUMAN, Q9GZX3
    Similarity: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CHST6_HUMAN, Q9GZX3
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation
    of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the
    non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures

    Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.2.172 EC 2.8.2.212 EC 2.8.22

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001517N-acetylglucosamine 6-O-sulfotransferase activity TAS11181564


    CHST6 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    MPS IIIC - Sanfilippo syndrome C1.00
    MPS IIIA - Sanfilippo syndrome A1.00
    MPS I - Hurler syndrome1.00
    MPS IIID - Sanfilippo syndrome D1.00
    Mucopolysaccharidoses1.00
    MPS IX - Natowicz syndrome1.00
    MPS IV - Morquio syndrome A1.00
    MPS II - Hunter syndrome1.00
    2Keratan sulfate biosynthesis
    Keratan sulfate biosynthesis1.00
    Glycosaminoglycan biosynthesis - keratan sulfate0.45
    Keratan sulfate/keratin metabolism0.84
    3Disease
    Disease1.00
    4Metabolism
    Metabolism1.00
    5Articular Cartilage Extracellular Matrix
    Articular Cartilage Extracellular Matrix1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for CHST6
        Articular Cartilage Extracellular Matrix


    1 BioSystems Pathway for CHST6 
        metapathway biotransformation

    5/18        Reactome Pathways for CHST6 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS II - Hunter syndrome


    1         Kegg Pathway  (Kegg details for CHST6):
        Glycosaminoglycan biosynthesis - keratan sulfate


    CHST6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHST6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for CHST6 (ENSP000003289834) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHST1ENSP000003092704STRING: ENSP00000309270
    KERAENSP000002667194STRING: ENSP00000266719
    LUMENSP000002667184STRING: ENSP00000266718
    OGNENSP000002625514STRING: ENSP00000262551
    ST3GAL3ENSP000002629154STRING: ENSP00000262915
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006044N-acetylglucosamine metabolic process IDA11352640
    GO:0006790sulfur compound metabolic process IDA11352640
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--


    CHST6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHST6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHST6

    2 HMDB Compounds for CHST6    About this table
    CompoundSynonyms CAS #PubMed Ids
    KeratanKerato sulfate (see all 4)69992-87-6--
    Poly-N-acetyllactosaminePoly(N-acetyllactosamine) (see all 6)82441-98-3--
    4 Novoseek chemical compound relationships for CHST6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    keratan sulfate 86.8 15 11278593 (4), 12218059 (4), 10510083 (1), 11352640 (1) (see all 5)
    n-acetylglucosamine 67.5 11 12672413 (1), 10510083 (1), 11278593 (1), 12882769 (1) (see all 7)
    sulfate 32.1 5 11278593 (2), 12218059 (1)
    galactose 23.1 1 10510083 (1)

    Search CenterWatch for drugs/clinical trials and news about CHST6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHST6 gene: 
    NM_021615.4  

    Unigene Cluster for CHST6:

    Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
    Hs.655622  [show with all ESTs]
    Unigene Representative Sequence: NM_021615
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332272(uc002fef.3 uc002feg.1 uc002feh.1) ENST00000390664


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    Additional cDNA sequence: 

    AF280086.1 AK093904.1 AK311527.1 BC036640.1 BC041645.1 BC074834.2 BC074883.2 

    5 DOTS entries:

    DT.99997725  DT.438406  DT.91959070  DT.100643414  DT.75153978 

    24/30 AceView cDNA sequences (see all 30):

    BC074834 BM715071 BX280599 BC074883 BQ181684 BU739978 AF280086 BU679155 
    AI824198 BU859309 NM_021615 BU678606 AI824100 CK431218 AI362200 AW151502 
    BG107354 AI991572 BC036640 BM046901 BM047763 BC041645 AI375973 AF219990 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHST6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAGGAGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CHST6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHST6

    SOURCE GeneReport for Unigene cluster: Hs.655622

    UniProtKB/Swiss-Prot: CHST6_HUMAN, Q9GZX3
    Tissue specificity: Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHST6 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CHST61 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase more 62.04(n)
    66.23(a)
      770257  XM_001232704.2  XP_001232705.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    62(a)
    43(a)
    1 ↔ many
    possible ortholog
    GL343483.1(236337-237652)
    2(192755869-192757653)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641662 hypothetical protein MGC64166 74.76(n)   393358  BC053293.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95506
    CG316376
    --
    18(a)
    18(a)
    many ↔ many
    many ↔ many
    2L(6497053-6498455)
    2L(6498642-6526996)


    ENSEMBL Gene Tree for CHST6 (if available)
    TreeFam Gene Tree for CHST6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHST6 gene
    CHST42  CHST12  CHST22  CHST32  CHST72  CHST52  
    6 SIMAP similar genes for CHST6 using alignment to 5 protein entries:     CHST6_HUMAN (see all proteins):
    CHST5    CHST4    CHST2    CHST1    CHST3    CHST7

    CHST6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/545 NCBI SNPs in CHST6 are shown (see all 545    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219178241,2
    Cpathogenic75512900(-) GGACCC/TGGCGC 2 P L mis10--------
    rs289378781,2
    Cpathogenic75513118(-) CGCGAC/ACCGCG 2 /E /D mis1 ese31Minor allele frequency- A:0.00NA 2
    rs289378791,2
    C,Fpathogenic75513128(-) GCACCT/GGGTGC 2 /R /L mis1 ese33Minor allele frequency- G:0.00NA 3798
    rs289378771,2
    Cpathogenic75513206(-) GCTCAA/GGGAGG 2 K R mis1 ese31Minor allele frequency- G:0.00NA 2
    rs725475441,2
    Cpathogenic75513398(-) TGCCTA/GTCTGC 2 Y C mis10--------
    rs1219178221,2
    Cpathogenic75513423(-) TCCTGG/TGCGAC 2 G C mis10--------
    rs1219178261,2
    Cpathogenic75513450(-) CTGTGA/CGCGAC 2 S R mis10--------
    rs1870232321,2
    --75506529(+) TGGGGC/TGCAGT 1 -- ds50010--------
    rs376051,2
    C,F,A,--75506572(-) CCTAGC/GTTTGT 1 -- ds50016Minor allele frequency- G:0.22NA WA EA 364
    rs9779871,2
    C,F,A,H,--75506593(-) GCCACC/TACAGA 1 -- ds500124Minor allele frequency- T:0.49NS EA NA WA CSA 2348

    HapMap Linkage Disequilibrium report for CHST6 (75507022 - 75529282 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CHST6
         1 CNV: 4013
    Human Gene Mutation Database (HGMD): CHST6

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CHST6 for disorders           About GeneDecksing

    OMIM gene information: 605294   
    OMIM disorders: 217800  
    UniProtKB/Swiss-Prot: CHST6_HUMAN, Q9GZX3
  • Defects in CHST6 are the cause of macular dystrophy, corneal, 1 (MCDC1) [MIM:217800]. An ocular disease
  • characterized by bilateral, progressive corneal opacification, and reduced corneal sensitivity. Onset occurs in the
    first decade, usually between ages 5 and 9. Painful attacks with photophobia, foreign body sensations, and recurrent
    erosions occur in most patients. The disease is due to deposition of an unsulfated keratan sulfate both within the
    intracellular space (within the keratocytes and endothelial cells) and in the extracellular corneal stroma. Macular
    corneal dystrophy is divided into the clinically indistinguishable types I, IA, and II based on analysis of the
    normally sulfated, or antigenic, keratan sulfate levels in serum and immunohistochemical evaluation of the cornea.
    Patients with types I and IA macular corneal dystrophy have undetectable serum levels of antigenic keratan sulfate,
    whereas those with type II macular corneal dystrophy have normal or low levels, depending on the population examined.
    Note=CHST6 homozygous missense mutations have been observed in patients with macular corneal dystrophy type I, while
    type II patients show a large deletion and replacement in the upstream region of CHST6. The only missense mutation for
    type II is Cys-50, which is heterozygous with a replacement in the upstream region on the other allele of CHST6

    12 diseases for CHST6:    About MalaCards
    macular corneal dystrophy    corneal dystrophy    lattice corneal dystrophy    irregular astigmatism
    corneal granular dystrophy    autosomal recessive disease    corneal disease    macular dystrophy
    astigmatism    influenza    cholesterol    immunodeficiency

    2 diseases from the University of Copenhagen DISEASES database for CHST6:
    Macular corneal dystrophy     Lattice corneal dystrophy

    2 Novoseek disease relationships for CHST6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    corneal dystrophy, macular type 93.7 3 15953452 (1), 17093400 (1)
    corneal diseases 71.7 2 16568029 (1), 12700042 (1)

    Genetic Association Database (GAD): CHST6
    Human Genome Epidemiology (HuGE) Navigator: CHST6 (1 document)

    Export disorders for CHST6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHST6 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with CHST6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel mutations in the carbohydrate sulfotransferase gene (CHST6) in American patients with macular corneal dystrophy. (PubMed id 15013869)1, 2, 4, 9 Aldave A.J....Small K. (2004)
    2. Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India. (PubMed id 14609920)1, 2, 4, 9 Warren J.F.... Margolis T.P. (2003)
    3. Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene. (PubMed id 11017086)1, 2, 3, 9 Akama T.O.... Fukuda M.N. (2000)
    4. Mutations in the CHST6 gene in patients with macular corneal dystrophy: immunohistochemical evidence of heterogeneity. (PubMed id 12882769)1, 2, 9 Iida-Hasegawa N.... Kanai A. (2003)
    5. Novel mutations of the carbohydrate sulfotransferase-6 (CHST6) gene causing macular corneal dystrophy in India. (PubMed id 14735064)1, 2, 9 Sultana A.... Klintworth G.K. (2003)
    6. Novel mutations in the CHST6 gene causing macular corneal dystrophy. (PubMed id 14984470)1, 2, 9 Abbruzzese C.... De Luca M. (2004)
    7. Truncating mutations in the carbohydrate sulfotransferase 6 gene (CHST6) result in macular corneal dystrophy. (PubMed id 12824236)1, 2, 9 Niel F.... Valleix S. (2003)
    8. Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. (PubMed id 12218059)1, 2, 9 Akama T.O.... Fukuda M.N. (2002)
    9. Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta). (PubMed id 11352640)1, 2, 9 Bartes A.... Hemmerich S. (2001)
    10. Mutations in corneal carbohydrate sulfotransferase 6 gene (CHST6) cause macular corneal dystrophy in Iceland. (PubMed id 11139648)1, 2, 9 Liu N.-P.... Klintworth G.K. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4166 HGNC: 6938 AceView: CHST6 Ensembl:ENSG00000183196 euGenes: HUgn4166
    ECgene: CHST6 Kegg: 4166 H-InvDB: CHST6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHST6 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHST6 gene:
    Search GeneIP for patents involving CHST6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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