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Aliases for CHST5 Gene

Aliases for CHST5 Gene

  • Carbohydrate Sulfotransferase 5 2 3 5
  • Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 4-Alpha 3 4
  • Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 5 2 3
  • N-Acetylglucosamine 6-O-Sulfotransferase 3 3 4
  • Intestinal GlcNAc-6-Sulfotransferase 3 4
  • GlcNAc6ST-3 3 4
  • I-GlcNAc6ST 3 4
  • GST4-Alpha 3 4
  • Gn6st-3 3 4
  • HIGn6ST 3 4
  • Intestinal N-Acetylglucosamine-6-O-Sulfotransferase 4
  • I-GlcNAc-6-ST 3
  • EC 2.8.2.17 61
  • EC 2.8.2.- 4
  • EC 2.8.2 61

External Ids for CHST5 Gene

Previous GeneCards Identifiers for CHST5 Gene

  • GC16M066492
  • GC16U900019
  • GC16M075301
  • GC16M075342
  • GC16M075343
  • GC16M074119
  • GC16M075562
  • GC16M061316

Summaries for CHST5 Gene

Entrez Gene Summary for CHST5 Gene

  • The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST5 Gene

CHST5 (Carbohydrate Sulfotransferase 5) is a Protein Coding gene. Diseases associated with CHST5 include Colon Mucinous Adenocarcinoma. Among its related pathways are Keratan sulfate/keratin metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and N-acetylglucosamine 6-O-sulfotransferase activity. An important paralog of this gene is CHST6.

UniProtKB/Swiss-Prot for CHST5 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location.

Gene Wiki entry for CHST5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST5 Gene

Genomics for CHST5 Gene

Regulatory Elements for CHST5 Gene

Enhancers for CHST5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G075482 1.4 ENCODE dbSUPER 11.8 +50.1 50106 4.6 HDGF FOXA2 PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ENSG00000261783 CHST5 TMEM231 GLG1 TMEM170A BCAR1 ENSG00000203472 CHST6
GH16G075471 1.2 Ensembl ENCODE 12 +62.9 62947 1.9 PKNOX1 ATF1 ARID4B ZNF2 SLC30A9 ZNF143 DEK SP5 MXD4 REST ENSG00000261783 CHST6 CHST5 TMEM231 ENSG00000252122 GABARAPL2 CFDP1 ENSG00000203472 TMEM170A
GH16G075501 1 Ensembl ENCODE dbSUPER 11.9 +33.3 33295 0.9 RFX1 AGO1 KDM6A TMEM231 ADAT1 CHST5 GABARAPL2 RNU6-758P ENSG00000273971 LOC100420067
GH16G075498 1 Ensembl dbSUPER 11.8 +36.3 36346 0.6 TFAP4 PKNOX1 NFIB SAP130 ARID4B FEZF1 ZIC2 ZNF366 SCRT2 PATZ1 CHST5 TMEM231 GABARAPL2 ADAT1 RNU6-758P ENSG00000273971 LOC100420067
GH16G075615 0.8 ENCODE 12 -81.4 -81398 2.0 MXI1 SAP30 ZNF384 CEBPG ZFHX2 EGR1 CBX5 EED ETV6 PRDM10 ADAT1 TMEM231 CHST5 GABARAPL2 ENSG00000259992
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHST5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHST5 Gene

Chromosome:
16
Start:
75,528,530 bp from pter
End:
75,535,247 bp from pter
Size:
6,718 bases
Orientation:
Minus strand

Genomic View for CHST5 Gene

Genes around CHST5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHST5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHST5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST5 Gene

Proteins for CHST5 Gene

  • Protein details for CHST5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZS9-CHST5_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 5
    Protein Accession:
    Q9GZS9
    Secondary Accessions:
    • B2RV23
    • Q7LCN3
    • Q9UBY3

    Protein attributes for CHST5 Gene

    Size:
    411 amino acids
    Molecular mass:
    46161 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD56000.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD56001.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHST5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHST5 Gene

Selected DME Specific Peptides for CHST5 Gene

Q9GZS9:
  • QHPDVFYLMEPAWHVW
  • LVRDPRAV
  • LHMAVRDL
  • VVLKEVRF

Post-translational modifications for CHST5 Gene

  • Glycosylation at posLast=138138, Asn327, and Asn350
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CHST5 Gene

Gene Families for CHST5 Gene

Protein Domains for CHST5 Gene

Suggested Antigen Peptide Sequences for CHST5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZS9

UniProtKB/Swiss-Prot:

CHST5_HUMAN :
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Family:
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
genes like me logo Genes that share domains with CHST5: view

Function for CHST5 Gene

Molecular function for CHST5 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location.

Enzyme Numbers (IUBMB) for CHST5 Gene

Gene Ontology (GO) - Molecular Function for CHST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity TAS --
GO:0008146 sulfotransferase activity TAS 10491328
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CHST5: view
genes like me logo Genes that share phenotypes with CHST5: view

Animal Model Products

CRISPR Products

miRNA for CHST5 Gene

miRTarBase miRNAs that target CHST5

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHST5 Gene

Localization for CHST5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein. Note=Golgi membrane, early secretory pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHST5 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA,IDA 12855678
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,NAS 10491328
GO:0031228 intrinsic component of Golgi membrane NAS 12855678
genes like me logo Genes that share ontologies with CHST5: view

Pathways & Interactions for CHST5 Gene

genes like me logo Genes that share pathways with CHST5: view

Pathways by source for CHST5 Gene

Interacting Proteins for CHST5 Gene

Gene Ontology (GO) - Biological Process for CHST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006044 N-acetylglucosamine metabolic process IDA 10491328
GO:0006477 protein sulfation TAS 10491328
GO:0006790 sulfur compound metabolic process IDA 10491328
GO:0018146 keratan sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHST5: view

No data available for SIGNOR curated interactions for CHST5 Gene

Drugs & Compounds for CHST5 Gene

(4) Additional Compounds for CHST5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Poly-N-acetyllactosamine
  • 2-(Acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-D-Glucose
  • 2-(Acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose homopolymer
  • N-Acetyl-4-O-beta-D-galactopyranosyl-D-glucosamine
  • N-Acetyl-lactosamine
  • O-beta-D-Galactopyranosyl-(14)-2-deoxy-2-acetamido-D-glucose
82441-98-3
genes like me logo Genes that share compounds with CHST5: view

Transcripts for CHST5 Gene

mRNA/cDNA for CHST5 Gene

Unigene Clusters for CHST5 Gene

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5:
SP6: - - - - - -
SP7:
SP8: -

Relevant External Links for CHST5 Gene

GeneLoc Exon Structure for
CHST5
ECgene alternative splicing isoforms for
CHST5

Expression for CHST5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHST5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST5 Gene

This gene is overexpressed in Colon - Transverse (x21.8) and Small Intestine - Terminal Ileum (x16.3).

Protein differential expression in normal tissues from HIPED for CHST5 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHST5 Gene



Protein tissue co-expression partners for CHST5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHST5 Gene:

CHST5

SOURCE GeneReport for Unigene cluster for CHST5 Gene:

Hs.745424

mRNA Expression by UniProt/SwissProt for CHST5 Gene:

Q9GZS9-CHST5_HUMAN
Tissue specificity: Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas.

Evidence on tissue expression from TISSUES for CHST5 Gene

  • Intestine(4.4)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CHST5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CHST5 Gene

Orthologs for CHST5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST5 34 35
  • 98.86 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Chst5 35
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CHST5 35
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9550 35
  • 21 (a)
ManyToMany
CG31637 35
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 20 (a)
ManyToMany
CSA.5535 35
  • 20 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
Species where no ortholog for CHST5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST5 Gene

ENSEMBL:
Gene Tree for CHST5 (if available)
TreeFam:
Gene Tree for CHST5 (if available)

Paralogs for CHST5 Gene

Paralogs for CHST5 Gene

(6) SIMAP similar genes for CHST5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CHST5 Gene

genes like me logo Genes that share paralogs with CHST5: view

Variants for CHST5 Gene

Sequence variations from dbSNP and Humsavar for CHST5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs869025261 Likely benign 75,529,648(-) CGGCA(C/T)CGTGC reference, missense
rs1000024597 -- 75,528,711(+) CCGGA(A/C)TAATT utr-variant-3-prime
rs1000073940 -- 75,529,047(+) GATAG(G/T)AGGGA utr-variant-3-prime
rs1000529948 -- 75,529,256(+) CAGCA(A/G)CTGCA reference, synonymous-codon
rs1000848031 -- 75,532,278(+) GTGGA(C/T)CTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST5 Gene

Variant ID Type Subtype PubMed ID
dgv10e24 CNV loss 17666407
dgv124n111 CNV duplication 26073780
dgv3020n100 CNV gain 25217958
dgv352n27 CNV gain 19166990
dgv491n67 CNV gain 20364138
dgv5189n54 CNV gain 21841781
dgv5190n54 CNV gain 21841781
dgv5191n54 CNV gain 21841781
dgv536e214 CNV gain 21293372
dgv54e203 CNV gain 21179565
dgv856e212 CNV gain 25503493
esv2647265 CNV deletion 19546169
esv2714710 CNV deletion 23290073
esv2758657 CNV gain 17122850
esv3639097 CNV loss 21293372
esv3892888 CNV gain+loss 25118596
esv3892889 CNV gain 25118596
nsv1056522 CNV gain+loss 25217958
nsv1059777 CNV loss 25217958
nsv1060805 CNV gain 25217958
nsv1063718 CNV gain 25217958
nsv1065995 CNV loss 25217958
nsv436838 CNV insertion 17901297
nsv442728 CNV gain 18776908
nsv457521 CNV gain 19166990
nsv516675 CNV gain+loss 19592680
nsv525955 CNV loss 19592680
nsv572979 CNV gain 21841781
nsv572981 CNV gain 21841781
nsv572988 CNV gain 21841781
nsv572994 CNV gain 21841781
nsv817738 CNV gain 17921354
nsv9461 CNV gain 18304495

Variation tolerance for CHST5 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHST5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHST5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST5 Gene

Disorders for CHST5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CHST5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colon mucinous adenocarcinoma
  • colonic mucinous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CHST5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHST5

Genetic Association Database (GAD)
CHST5
Human Genome Epidemiology (HuGE) Navigator
CHST5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHST5
genes like me logo Genes that share disorders with CHST5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHST5 Gene

Publications for CHST5 Gene

  1. Cloning and characterization of a mammalian N-acetylglucosamine-6- sulfotransferase that is highly restricted to intestinal tissue. (PMID: 10491328) Lee J.K. … Hemmerich S. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications. (PMID: 12626414) Lee J.K. … Rosen S.D. (Glycobiology 2003) 3 4 22 64
  3. Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. (PMID: 12218059) Akama T.O. … Fukuda M.N. (J. Biol. Chem. 2002) 3 4 22 64
  4. Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta). (PMID: 11352640) Bartes A. … Hemmerich S. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
  5. Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene. (PMID: 11017086) Akama T.O. … Fukuda M.N. (Nat. Genet. 2000) 2 3 4 64

Products for CHST5 Gene

Sources for CHST5 Gene

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