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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHST5 Gene

protein-coding   GIFtS: 55
GCID: GC16M075562

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase...
 Explore 10 diseases affiliated with
CHST5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CHST5    

Aliases
for CHST5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 51 2     Carbohydrate Sulfotransferase 52
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 4-Alpha2 3     GlcNAc6ST-33
Intestinal GlcNAc-6-Sulfotransferase2 3     Gn6st-33
GST4-Alpha1     EC 2.8.2.-3
I-GlcNAc6ST2 3     GlcNAc6ST-33
HIGn6ST1     Gn6st-33
N-Acetylglucosamine 6-O-Sulfotransferase 32 3     Intestinal N-Acetylglucosamine-6-O-Sulfotransferase3
FLJ221671     EC 2.8.28
I-GLCNAC-6-ST1     EC 2.8.2.178
I-GlcNAc-6-ST2     

External Ids:    HGNC: 19731   Entrez Gene: 235632   Ensembl: ENSG000001357027   OMIM: 6048175   UniProtKB: Q9GZS93   

Export aliases for CHST5 gene to outside databases

Previous GC identifers: GC16M066492 GC16U900019 GC16M075301 GC16M075342 GC16M075343 GC16M074119 GC16M061316


Summaries
for CHST5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CHST5:
The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which
catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or
N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors.
Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon
and small intestine. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: CHST5_HUMAN, Q9GZS9
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of
mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not
transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity
toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced
by its subcellular location

Gene Wiki entry for CHST5


Genomic Views
for CHST5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHST5 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-5   MIF-1   Nkx3-1 v1   NF-kappaB   AP-2gamma   Nkx3-1 v2   Nkx3-1 v3   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CHST5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.3   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q23.1

CHST5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M075562:  view genomic region     (about GC identifiers)

Start:
 75,562,428 bp from pter      End:
 75,569,145 bp from pter
Size:
 6,718 bases      Orientation:
 minus strand

Proteins
for CHST5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CHST5_HUMAN, Q9GZS9 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 5  
Size: 411 amino acids; 46161 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Note=Golgi membrane,
early secretory pathway
Sequence caution: Sequence=AAD56000.1; Type=Erroneous initiation; Sequence=AAD56001.1; Type=Erroneous initiation;
Secondary accessions: B2RV23 Q7LCN3 Q9UBY3
Alternative splicing: 2 isoforms:  Q9GZS9-1   Q9GZS9-2   

Explore the universe of human proteins at neXtProt for CHST5: NX_Q9GZS9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9GZS9

    • 4 DME Specific Peptides for CHST5 (Q9GZS9)
     LVRDPRAV  LHMAVRDL  VVLKEVRF  QHPDVFYLMEPAWHVW 

    CHST5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_078809.2  
    ENSEMBL proteins: 
     ENSP00000338783   ENSP00000454375   ENSP00000441220  
    Reactome Protein details: Q9GZS9
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: CHST5
    OriGene Custom Protein Services for CHST5 
    GenScript Custom Purified and Recombinant Proteins Services for CHST5
    Novus Biologicals CHST5 Protein
    Novus Biologicals CHST5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CHST5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus IDA12855678
    GO:0016021integral to membrane NAS10491328
    GO:0031228intrinsic to Golgi membrane NAS12855678


    CHST5 for ontologies           About GeneDecksing



    CHST5 Antibody Products: 
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    Novus Biologicals CHST5 Antibodies
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    Uscn Antibodies for CHST5
    Search ThermoFisher Antibodies for CHST5

    Assay Products for CHST5: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for CHST5

    Protein Domains /
    Families
    for CHST5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CHST5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR016469 Carbohydrate_sulfotransferase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZS9

    ProtoNet protein and cluster: Q9GZS9

    UniProtKB/Swiss-Prot: CHST5_HUMAN, Q9GZS9
    Similarity: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily


    Function
    for CHST5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CHST5_HUMAN, Q9GZS9
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of
    mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not
    transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity
    toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced
    by its subcellular location

    Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.2.172 EC 2.8.22

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST5
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    SwitchGear 3'UTR luciferase reporter plasmid: CHST5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHST5 (see all 7)
    OriGene shRNA RFP: CHST5
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CHST5

    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST5 

    Cell Line
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    Search LifeMap BioReagents cell lines for CHST5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST5

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001517N-acetylglucosamine 6-O-sulfotransferase activity IDA10491328
    GO:0008146sulfotransferase activity TAS10491328


    CHST5 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CHST5:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
         Mouse knock-out Chst5tm1Knsh for CHST5
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Chst5):
     vision/eye 

    CHST5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CHST5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIIA - Sanfilippo syndrome A1.00
    		MPS I - Hurler syndrome1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		Mucopolysaccharidoses1.00
    		MPS IX - Natowicz syndrome1.00
    		MPS IV - Morquio syndrome A1.00
    		MPS II - Hunter syndrome1.00
    2Keratan sulfate biosynthesis
    		Keratan sulfate biosynthesis1.00
    		Keratan sulfate/keratin metabolism0.84
    3Disease
    		Disease1.00
    4Metabolism
    		Metabolism1.00
    5Articular Cartilage Extracellular Matrix
    		Articular Cartilage Extracellular Matrix1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for CHST5
        Articular Cartilage Extracellular Matrix


    1 BioSystems Pathway for CHST5 
        metapathway biotransformation

    5/18        Reactome Pathways for CHST5 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS II - Hunter syndrome



    CHST5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHST5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for CHST5 (ENSP000003387834) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHST1ENSP000003092704STRING: ENSP00000309270
    KERAENSP000002667194STRING: ENSP00000266719
    LUMENSP000002667184STRING: ENSP00000266718
    ST3GAL3ENSP000002629154STRING: ENSP00000262915
    FMODENSP000003470414STRING: ENSP00000347041
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006044N-acetylglucosamine metabolic process IDA12218059
    GO:0006477protein sulfation TAS10491328
    GO:0006790sulfur compound metabolic process IDA10491328
    GO:0018146keratan sulfate biosynthetic process TAS--


    CHST5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CHST5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHST5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHST5

    1 HMDB Compound for CHST5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Poly-N-acetyllactosaminePoly(N-acetyllactosamine) (see all 6)82441-98-3--
    3 Novoseek chemical compound relationships for CHST5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    keratan sulfate 76.9 2 12218059 (2)
    n-acetylglucosamine 60.3 4 11352640 (1)
    sulfate 57 1 12218059 (1)

    Search CenterWatch for drugs/clinical trials and news about CHST5 

    Transcripts
    for CHST5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CHST5 gene (2 alternative transcripts): 
    NM_024533.4  NM_012126.1  

    Unigene Cluster for CHST5:

    Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
    Hs.710689  [show with all ESTs]
    Unigene Representative Sequence: AF246718
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336257(uc002fei.3) ENST00000565039 ENST00000541075

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: CHST5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHST5 (see all 7)
    OriGene shRNA RFP: CHST5
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CHST5 (NM_024533)
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    Primer
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    Additional cDNA sequence: 

    AF246718.1 BC147002.1 BC147007.1 

    3 DOTS entries:

    DT.100811812  DT.75153978  DT.99997725 

    24/203 AceView cDNA sequences (see all 203):

    AI598171 BM462730 BG034525 BC010609 BQ214095 AK001687 AK025820 AA973443 
    BM799766 BX098470 BU630338 AK057689 AI348199 AA918258 BU685225 D31292 
    BM973146 AA911949 CA311781 AA417994 BQ648908 BX282540 BF509489 BI824736 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CHST5 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -           -                 -           -     -                 -                                             
    SP2:              -                             -           -     -                 -                                             
    SP3:              -           -                 -                 -     -     -                                                   
    SP4:                          -                 -           -     -                 -                                             
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CHST5

    Expression
    for CHST5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHST5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCACTGCACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CHST5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHST5

    SOURCE GeneReport for Unigene cluster: Hs.710689

    UniProtKB/Swiss-Prot: CHST5_HUMAN, Q9GZS9
    Tissue specificity: Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes.
    Not expressed in other tissues. Down-regulated in colonic adenocarcinomas

        SABiosciences Custom PCR Arrays for CHST5
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST5

    Orthologs
    for CHST5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CHST5 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CHST66
    		 Uncharacterized protein
    		 61(a)
    		 1 → many
    		 11(21898871-21900052)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 58(a)
    43(a)
    		 1 ↔ many
    possible ortholog
    		 GL343483.1(236337-237652)
    2(192755869-192757653)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1948796
    		 zgc:194879
    		 49(a)
    		 1 → many
    		 25(35925935-35939027)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG95506
    CG316376
    		 --
    		 19(a)
    18(a)
    		 many ↔ many
    many ↔ many
    		 2L(6497053-6498455)
    2L(6498642-6526996)


    ENSEMBL Gene Tree for CHST5 (if available)
    TreeFam Gene Tree for CHST5 (if available) 

    Paralogs
    for CHST5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHST5 gene
    CHST42  CHST12  CHST22  CHST32  CHST62  CHST72  
    6 SIMAP similar genes for CHST5 using alignment to 2 protein entries:     CHST5_HUMAN (see all proteins):
    CHST6    CHST4    CHST2    CHST3    CHST7    CHST1

    CHST5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CHST5
    PGOHUM00000242500


    Genomic Variants
    for CHST5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/204 NCBI SNPs in CHST5 are shown (see all 204)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs750206851,2
    		C,--61315657(+) CTTTGT/CTCAGG 1 -- ds50012Minor allele frequency- C:0.04NA 122
    rs80585861,2
    		C,F,H,--61315856(+) cagtcT/Cgcccc 1 -- ds50017Minor allele frequency- C:0.16NS NA WA 1006
    rs3941501,2
    		F--61317304(-) AACCTA/GCGCAT 2 L syn1 ese31Minor allele frequency- G:0.40MN 184
    rs1127491551,2
    		--61318070(+) GAATAG/CGGAGT 1 -- ut511Minor allele frequency- C:0.50CSA 2
    rs747803011,2
    		--61318201(+) TCTATC/GTGTAG 1 -- ut511Minor allele frequency- G:0.01WA 118
    rs762231621,2
    		C,F,--61318231(+) AAGAGA/GACTCC 1 -- ut511Minor allele frequency- G:0.03WA 118
    rs25509151,2
    		C,F,H,--61318340(-) ACCTCG/CGCGAG 1 -- ut518Minor allele frequency- C:0.07NS NA WA CSA 332
    rs1166460601,2
    		C,F,--61318428(+) TTACCC/TGTGTG 1 -- ut511Minor allele frequency- T:0.02WA 118
    rs755811121,2
    		--61318477(+) TGGGGG/TGATTG 1 -- ut510--------
    rs25509141,2
    		C,F,--61318624(-) TGAGCC/AACCGC 1 -- ut51 ese32Minor allele frequency- A:0.50NA CSA 4

    HapMap Linkage Disequilibrium report for CHST5 (75562428 - 75569145 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for CHST5
         11 CNVs: 88219 49761 30791 102332 77420 53835 37695 77421 4013 49760 9763

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CHST5

    Disorders / Diseases
    for CHST5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CHST5 for disorders           About GeneDecksing

    OMIM gene information: 604817    OMIM disorders: --

    10 diseases for CHST5:    About MalaCards
    macular corneal dystrophy    corneal dystrophy    mucinous adenocarcinoma    colon mucinous adenocarcinoma
    colon adenocarcinoma    adenocarcinoma    esophagitis    cholesterol
    immunodeficiency    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for CHST5:
    Macular corneal dystrophy     Mucinous adenocarcinoma
    Human Genome Epidemiology (HuGE) Navigator: CHST5 (4 documents)

    Export disorders for CHST5 gene to outside databases

    Publications
    for CHST5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHST5 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CHST5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a mammalian N-acetylglucosamine-6- sulfotransferase that is highly restricted to intestinal tissue. (PubMed id 10491328)1, 2, 3, 9 Lee J.K.... Hemmerich S. (1999)
    2. Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene. (PubMed id 11017086)1, 2, 3 Akama T.O.... Fukuda M.N. (2000)
    3. Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications. (PubMed id 12626414)1, 2, 9 Lee J.K.... Rosen S.D. (2003)
    4. Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. (PubMed id 12218059)1, 2, 9 Akama T.O.... Fukuda M.N. (2002)
    5. Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta). (PubMed id 11352640)1, 2, 9 Bartes A.... Hemmerich S. (2001)
    6. Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis. (PubMed id 12855678)1, 2 de Graffenried C.L. and Bertozzi C.R. (2003)
    7. Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma. (PubMed id 12107080)1, 2 Seko A.... Yamashita K. (2002)
    8. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1 Dastani Z....Genest J. (2010)
    9. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1 Liu C.Y....Christiani D.C. (2010)
    10. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1 Saito A....Kamatani N. (2009)

    External Searches for CHST5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CHST5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23563 HGNC: 1973 AceView: ADAT1andCHST5 Ensembl:ENSG00000135702 euGenes: HUgn23563
    ECgene: CHST5 H-InvDB: CHST5

    Other Databases showing CHST5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CHST5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHST5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    Intellectual Property
    for CHST5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CHST5 gene:
    Search GeneIP for patents involving CHST5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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