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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHST5 Gene

protein-coding   GIFtS: 57
GCID: GC16M075562

Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 51 2     glcNAc6ST-32
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase
4-Alpha2 3
     gn6st-32
Intestinal GlcNAc-6-Sulfotransferase2 3     EC 2.8.2.-3
GST4-alpha2 3     GlcNAc6ST-33
I-GlcNAc6ST2 3     Gn6st-33
hIGn6ST2 3     Intestinal N-Acetylglucosamine-6-O-Sulfotransferase3
N-Acetylglucosamine 6-O-Sulfotransferase 32 3     EC 2.8.28
I-GlcNAc-6-ST2     EC 2.8.2.178
Carbohydrate Sulfotransferase 52     

External Ids:    HGNC: 19731   Entrez Gene: 235632   Ensembl: ENSG000001357027   OMIM: 6048175   UniProtKB: Q9GZS93   

Export aliases for CHST5 gene to outside databases

Previous GC identifers: GC16M066492 GC16U900019 GC16M075301 GC16M075342 GC16M075343 GC16M074119 GC16M061316


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHST5 Gene:
The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of
which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or
N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type
acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly
expressed in colon and small intestine. (provided by RefSeq, Aug 2011)

GeneCards Summary for CHST5 Gene: 
CHST5 (carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5) is a protein-coding gene. Diseases associated with CHST5 include colon mucinous adenocarcinoma, and macular corneal dystrophy, and among its related super-pathways are Metabolism of carbohydrates and Keratan sulfate/keratin metabolism. GO annotations related to this gene include sulfotransferase activity and N-acetylglucosamine 6-O-sulfotransferase activity. An important paralog of this gene is CHST4.

UniProtKB/Swiss-Prot: CHST5_HUMAN, Q9GZS9
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of
mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does
not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no
activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may
be influenced by its subcellular location

Gene Wiki entry for CHST5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHST5 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-5   MIF-1   Nkx3-1 v1   NF-kappaB   AP-2gamma   Nkx3-1 v2   Nkx3-1 v3   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CHST5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.3   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q23.1

CHST5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M075562:  view genomic region     (about GC identifiers)

Start:
75,562,428 bp from pter      End:
75,569,145 bp from pter
Size:
6,718 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHST5_HUMAN, Q9GZS9 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 5  
Size: 411 amino acids; 46161 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Note=Golgi
membrane, early secretory pathway
Sequence caution: Sequence=AAD56000.1; Type=Erroneous initiation; Sequence=AAD56001.1; Type=Erroneous initiation;
Secondary accessions: B2RV23 Q7LCN3 Q9UBY3
Alternative splicing: 2 isoforms:  Q9GZS9-1   Q9GZS9-2   

Explore the universe of human proteins at neXtProt for CHST5: NX_Q9GZS9

Explore proteomics data for CHST5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9GZS9

  • 4 DME Specific Peptides for CHST5 (Q9GZS9)
     LVRDPRAV  LHMAVRDL  VVLKEVRF  QHPDVFYLMEPAWHVW 

    CHST5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHST5 Protein Expression
    REFSEQ proteins: NP_078809.2  
    ENSEMBL proteins: 
     ENSP00000338783   ENSP00000454375   ENSP00000441220  
    Reactome Protein details: Q9GZS9
    Human Recombinant Protein Products for CHST5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CHST5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CHST5
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    Novus Biologicals CHST5 Protein
    Novus Biologicals CHST5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHST5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus IDA12855678
    GO:0016021integral to membrane NAS10491328
    GO:0031228intrinsic to Golgi membrane NAS12855678

    CHST5 for ontologies           About GeneDecksing



    CHST5 Antibody Products: 
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    Abcam antibodies for CHST5
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    LSBio Antibodies in human, mouse, rat for CHST5 

    Assay Products for CHST5: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CHST5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHST5 
    Cloud-Clone Corp. CLIAs for CHST5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR016469 Carbohydrate_sulfotransferase
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9GZS9

    ProtoNet protein and cluster: Q9GZS9

    UniProtKB/Swiss-Prot: CHST5_HUMAN, Q9GZS9
    Similarity: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily


    CHST5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHST5_HUMAN, Q9GZS9
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of
    mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does
    not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no
    activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may
    be influenced by its subcellular location

         Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.2.172 EC 2.8.22

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001517N-acetylglucosamine 6-O-sulfotransferase activity IDA10491328
    GO:0008146sulfotransferase activity TAS10491328
         
    CHST5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CHST5:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Chst5):
     vision/eye 

    CHST5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Chst5tm1Knsh for CHST5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHST5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHST5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST5 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST5
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    SwitchGear 3'UTR luciferase reporter plasmidCHST5 3' UTR sequence
    Inhib. RNA
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST5
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                         Customized lentivirus expression plasmids for stable overexpression of CHST5 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHST5 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    2Keratan sulfate biosynthesis
    Keratan sulfate biosynthesis0.82
    Keratan sulfate/keratin metabolism0.82
    3Biological oxidations
    metapathway biotransformation0.41
    4Metabolism
    Metabolism0.40
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CHST5
        Articular Cartilage Extracellular Matrix


    1 BioSystems Pathway for CHST5
        metapathway biotransformation

    5/18        Reactome Pathways for CHST5 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS II - Hunter syndrome



    CHST5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHST5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for CHST5 (ENSP000003387834) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHST1ENSP000003092704STRING: ENSP00000309270
    KERAENSP000002667194STRING: ENSP00000266719
    LUMENSP000002667184STRING: ENSP00000266718
    ST3GAL3ENSP000002629154STRING: ENSP00000262915
    FMODENSP000003470414STRING: ENSP00000347041
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006044N-acetylglucosamine metabolic process IDA10491328
    GO:0006477protein sulfation TAS10491328
    GO:0006790sulfur compound metabolic process IDA10491328
    GO:0018146keratan sulfate biosynthetic process TAS--

    CHST5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHST5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHST5

    1 HMDB Compound for CHST5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Poly-N-acetyllactosaminePoly(N-acetyllactosamine) (see all 6)82441-98-3--

    3 Novoseek inferred chemical compound relationships for CHST5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    keratan sulfate 76.9 2 12218059 (2)
    n-acetylglucosamine 60.3 4 11352640 (1)
    sulfate 57 1 12218059 (1)

    Search CenterWatch for drugs/clinical trials and news about CHST5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHST5 gene (2 alternative transcripts): 
    NM_024533.4  NM_012126.1  

    Unigene Cluster for CHST5:

    Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
    Hs.745424  [show with all ESTs]
    Unigene Representative Sequence: AF246718
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336257(uc002fei.3) ENST00000565039 ENST00000541075
    miRNA
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST5
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST5

    Additional mRNA sequence: 

    AF246718.1 BC147002.1 BC147007.1 

    1 DOTS entry:

    DT.100811812 

    24/203 AceView cDNA sequences (see all 203):

    AA973443 AW004791 AA417994 BI334712 BQ648908 BQ214095 AI222794 BU685225 
    BX280059 BU630338 BM462730 AA918258 CR620108 AU133015 AA911949 BC010609 
    AL598909 AI333375 AA398169 BU173659 BX352992 AK025820 AI248552 AA203681 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CHST5 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -           -                 -           -     -                 -                                             
    SP2:              -                             -           -     -                 -                                             
    SP3:              -           -                 -                 -     -     -                                                   
    SP4:                          -                 -           -     -                 -                                             
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CHST5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHST5 expression in normal human tissues (normalized intensities)      CHST5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACTGCACC
    CHST5 Expression
    About this image


    CHST5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium   
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See CHST5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHST5

    SOURCE GeneReport for Unigene cluster: Hs.745424

    UniProtKB/Swiss-Prot: CHST5_HUMAN, Q9GZS9
    Tissue specificity: Predominantly expressed in small and large intestines and colon. Weakly expressed in
    lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas

        SABiosciences Custom PCR Arrays for CHST5
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHST5 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst55 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase more   --   8 (58.11 cM) 111889135 
    chicken
    (Gallus gallus)
    Aves CHST66
    Uncharacterized protein
    61(a)
    1 → many
    11(19363500-19369931)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    59(a)
    43(a)
    1 ↔ many
    possible ortholog
    GL343483.1(236337-237652)
    2(192755869-192757653)
    zebrafish
    (Danio rerio)
    Actinopterygii CHST66
    carbohydrate (N-acetylglucosamine 6-O) sulfotransf...
    49(a)
    1 → many
    25(35925935-35939027)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95506
    CG316376
    --
    18(a)
    18(a)
    many ↔ many
    many ↔ many
    2L(6497053-6498455)
    2L(6498642-6526996)


    ENSEMBL Gene Tree for CHST5 (if available)
    TreeFam Gene Tree for CHST5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHST5 gene
    CHST42  CHST12  CHST22  CHST32  CHST62  CHST72  
    6 SIMAP similar genes for CHST5 using alignment to 2 protein entries:     CHST5_HUMAN (see all proteins):
    CHST6    CHST4    CHST2    CHST3    CHST7    CHST1

    CHST5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CHST5
    PGOHUM00000242500


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/271 SNPs in CHST5 are shown (see all 271)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25508851,2
    C,F--75570162(+) GCATAT/CGACTG 1 -- us2k16Minor allele frequency- C:0.27WA NA CSA EA 364
    rs1838500461,2
    --75570197(+) GGCAGG/TCAGAT 1 -- us2k10--------
    rs1152864331,2
    F--75570410(+) CAAAGC/AGAGAC 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1162480741,2
    F--75570415(+) CGAGAC/TTCCAT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1877630231,2
    --75570596(+) TGGTCA/GTAAGT 1 -- us2k10--------
    rs1506959631,2
    --75570598(+) GTCATA/CAGTTT 1 -- us2k10--------
    rs1398363421,2
    --75570627(+) AAATAA/CACCAG 1 -- us2k10--------
    rs1895568901,2
    --75570745(+) TAACTC/TCTGTG 1 -- us2k10--------
    rs1498381021,2
    C--75570818(+) AGTTCC/GAGACC 1 -- us2k10--------
    rs1822536701,2
    --75570835(+) ACCACA/CAGGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHST5 (75562428 - 75569145 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for CHST5 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714710CNV Deletion23290073
    esv2647265CNV Deletion19546169
    nsv436838CNV Insertion17901297
    dgv10e24CNV Loss17666407
    nsv906918CNV Loss21882294
    nsv525955CNV Loss19592680
    nsv906925CNV Loss21882294
    nsv817738CNV Gain17921354
    dgv352n27CNV Gain19166990
    dgv2914n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CHST5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604817    OMIM disorders: --

    11 diseases for CHST5:    About MalaCards
    colon mucinous adenocarcinoma    macular corneal dystrophy    mucinous adenocarcinoma    morquio syndrome b
    esophageal adenocarcinoma    corneal dystrophy    colon adenocarcinoma    adenocarcinoma
    esophagitis    endotheliitis    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for CHST5:
    Macular corneal dystrophy     Mucinous adenocarcinoma

    CHST5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHST5
    Human Genome Epidemiology (HuGE) Navigator: CHST5 (4 documents)

    Export disorders for CHST5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHST5 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with CHST5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a mammalian N-acetylglucosamine-6- sulfotransferase that is highly restricted to intestinal tissue. (PubMed id 10491328)1, 2, 3, 9 Lee J.K.... Hemmerich S. (1999)
    2. Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene. (PubMed id 11017086)1, 2, 3 Akama T.O.... Fukuda M.N. (2000)
    3. Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications. (PubMed id 12626414)1, 2, 9 Lee J.K.... Rosen S.D. (2003)
    4. Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. (PubMed id 12218059)1, 2, 9 Akama T.O.... Fukuda M.N. (2002)
    5. Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta). (PubMed id 11352640)1, 2, 9 Bartes A.... Hemmerich S. (2001)
    6. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (2010)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    8. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    9. Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis. (PubMed id 12855678)1, 2 de Graffenried C.L. and Bertozzi C.R. (2003)
    10. Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma. (PubMed id 12107080)1, 2 Seko A.... Yamashita K. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23563 HGNC: 1973 AceView: ADAT1andCHST5 Ensembl:ENSG00000135702 euGenes: HUgn23563
    ECgene: CHST5 H-InvDB: CHST5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHST5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHST5 gene:
    Search GeneIP for patents involving CHST5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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