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Aliases for CHST5 Gene

Aliases for CHST5 Gene

  • Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 5 2 3
  • Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 4-Alpha 3 4
  • N-Acetylglucosamine 6-O-Sulfotransferase 3 3 4
  • Intestinal GlcNAc-6-Sulfotransferase 3 4
  • GlcNAc6ST-3 3 4
  • I-GlcNAc6ST 3 4
  • GST4-Alpha 3 4
  • Gn6st-3 3 4
  • HIGn6ST 3 4
  • Intestinal N-Acetylglucosamine-6-O-Sulfotransferase 4
  • Carbohydrate Sulfotransferase 5 3
  • I-GlcNAc-6-ST 3
  • EC 2.8.2.17 64
  • EC 2.8.2.- 4
  • EC 2.8.2 64

External Ids for CHST5 Gene

Summaries for CHST5 Gene

Entrez Gene Summary for CHST5 Gene

  • The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST5 Gene

CHST5 (Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 5) is a Protein Coding gene. Diseases associated with CHST5 include macular corneal dystrophy and mucopolysaccharidoses. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include sulfotransferase activity and N-acetylglucosamine 6-O-sulfotransferase activity. An important paralog of this gene is CHST2.

UniProtKB/Swiss-Prot for CHST5 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location.

Gene Wiki entry for CHST5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST5 Gene

Genomics for CHST5 Gene

Genomic Location for CHST5 Gene

Start:
75,528,530 bp from pter
End:
75,535,247 bp from pter
Size:
6,718 bases
Orientation:
Minus strand

Genomic View for CHST5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHST5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST5 Gene

Regulatory Elements for CHST5 Gene

Proteins for CHST5 Gene

  • Protein details for CHST5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZS9-CHST5_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 5
    Protein Accession:
    Q9GZS9
    Secondary Accessions:
    • B2RV23
    • Q7LCN3
    • Q9UBY3

    Protein attributes for CHST5 Gene

    Size:
    411 amino acids
    Molecular mass:
    46161 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD56000.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD56001.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHST5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHST5 Gene

Proteomics data for CHST5 Gene at MOPED

Selected DME Specific Peptides for CHST5 Gene

Post-translational modifications for CHST5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn138, Asn327, and Asn350

Other Protein References for CHST5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CHST5 Gene

Gene Families for CHST5 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for CHST5 Gene

UniProtKB/Swiss-Prot:

CHST5_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.:
    • Q9GZS9
genes like me logo Genes that share domains with CHST5: view

Function for CHST5 Gene

Molecular function for CHST5 Gene

UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location.

Enzyme Numbers (IUBMB) for CHST5 Gene

Gene Ontology (GO) - Molecular Function for CHST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity IDA 10491328
GO:0008146 sulfotransferase activity TAS 10491328
genes like me logo Genes that share ontologies with CHST5: view
genes like me logo Genes that share phenotypes with CHST5: view

Animal Models for CHST5 Gene

MGI Knock Outs for CHST5:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CHST5 Gene

Localization for CHST5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein. Note=Golgi membrane, early secretory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST5 Gene COMPARTMENTS Subcellular localization image for CHST5 gene
Compartment Confidence
golgi apparatus 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA 12855678
GO:0016021 integral component of membrane NAS 10491328
GO:0031228 intrinsic component of Golgi membrane NAS 12855678
genes like me logo Genes that share ontologies with CHST5: view

Pathways for CHST5 Gene

genes like me logo Genes that share pathways with CHST5: view

Pathways by source for CHST5 Gene

1 R&D Systems pathway for CHST5 Gene
1 BioSystems pathway for CHST5 Gene

Interacting Proteins for CHST5 Gene

Gene Ontology (GO) - Biological Process for CHST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006044 N-acetylglucosamine metabolic process IDA 10491328
GO:0006477 protein sulfation TAS 10491328
GO:0006790 sulfur compound metabolic process IDA 10491328
GO:0018146 keratan sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHST5: view

Compounds for CHST5 Gene

(1) HMDB Compounds for CHST5 Gene

Compound Synonyms Cas Number PubMed IDs
Poly-N-acetyllactosamine
  • Poly(N-acetyllactosamine)
82441-98-3

(3) Novoseek inferred chemical compound relationships for CHST5 Gene

Compound -log(P) Hits PubMed IDs
keratan sulfate 76.9 2
n-acetylglucosamine 60.3 1
sulfate 57 1
genes like me logo Genes that share compounds with CHST5: view

Transcripts for CHST5 Gene

mRNA/cDNA for CHST5 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(203) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHST5 Gene

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHST5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5:
SP6: - - - - - -
SP7:
SP8: -

Relevant External Links for CHST5 Gene

GeneLoc Exon Structure for
CHST5
ECgene alternative splicing isoforms for
CHST5

Expression for CHST5 Gene

mRNA expression in normal human tissues for CHST5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST5 Gene

This gene is overexpressed in Colon - Transverse (21.8) and Small Intestine - Terminal Ileum (16.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHST5 Gene

SOURCE GeneReport for Unigene cluster for CHST5 Gene Hs.745424

mRNA Expression by UniProt/SwissProt for CHST5 Gene

Q9GZS9-CHST5_HUMAN
Tissue specificity: Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas.
genes like me logo Genes that share expressions with CHST5: view

Orthologs for CHST5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST5 36
  • 98.86 (n)
  • 99.03 (a)
CHST5 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Chst5 16
Chst5 37
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CHST5 37
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31637 37
  • 19 (a)
ManyToMany
CG9550 37
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 19 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
-- 37
  • 22 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
CSA.5535 37
  • 20 (a)
ManyToMany
Species with no ortholog for CHST5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST5 Gene

ENSEMBL:
Gene Tree for CHST5 (if available)
TreeFam:
Gene Tree for CHST5 (if available)

Paralogs for CHST5 Gene

Paralogs for CHST5 Gene

Selected SIMAP similar genes for CHST5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CHST5 Gene

genes like me logo Genes that share paralogs with CHST5: view

Variants for CHST5 Gene

Sequence variations from dbSNP and Humsavar for CHST5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs383400 -- 75,529,368(-) ATCGA(A/G)GCCTT synonymous-codon, reference
rs394150 -- 75,529,734(-) AACCT(A/G)CGCAT synonymous-codon, reference
rs2017265 -- 75,532,458(-) AGGCA(A/G/T)GGAGC intron-variant
rs2432619 -- 75,534,181(+) CCATC(G/T)CTAAA intron-variant
rs2453141 -- 75,535,607(+) CAGAC(A/G)TGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CHST5 Gene

Variant ID Type Subtype PubMed ID
dgv902e1 CNV Complex 17122850
nsv525955 CNV Loss 19592680
nsv457521 CNV Gain 19166990
esv2714710 CNV Deletion 23290073
nsv516675 CNV Gain+Loss 19592680
dgv2913n71 CNV Gain 21882294
nsv906917 CNV Gain+Loss 21882294
esv2647265 CNV Deletion 19546169
nsv906918 CNV Loss 21882294
nsv9461 CNV Gain 18304495
nsv436838 CNV Insertion 17901297
dgv491n67 CNV Gain 20364138
dgv2914n71 CNV Gain 21882294
dgv352n27 CNV Gain 19166990
nsv906925 CNV Loss 21882294
nsv906926 CNV Gain 21882294
nsv442728 CNV CNV 18776908
nsv817738 CNV Gain 17921354
dgv10e24 CNV Loss 17666407
nsv906927 CNV Gain 21882294
nsv906928 CNV Gain 21882294

Relevant External Links for CHST5 Gene

HapMap Linkage Disequilibrium report
CHST5

Disorders for CHST5 Gene

(2) University of Copenhagen DISEASES for CHST5 Gene

Relevant External Links for CHST5

Genetic Association Database (GAD)
CHST5
Human Genome Epidemiology (HuGE) Navigator
CHST5
genes like me logo Genes that share disorders with CHST5: view

No data available for UniProtKB/Swiss-Prot for CHST5 Gene

Publications for CHST5 Gene

  1. Cloning and characterization of a mammalian N-acetylglucosamine-6- sulfotransferase that is highly restricted to intestinal tissue. (PMID: 10491328) Lee J.K. … Hemmerich S. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta). (PMID: 11352640) Bartes A. … Hemmerich S. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  3. Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene. (PMID: 11017086) Akama T.O. … Fukuda M.N. (Nat. Genet. 2000) 2 3 4
  4. Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. (PMID: 12218059) Akama T.O. … Fukuda M.N. (J. Biol. Chem. 2002) 3 4 23
  5. Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications. (PMID: 12626414) Lee J.K. … Rosen S.D. (Glycobiology 2003) 3 4 23

Products for CHST5 Gene

Sources for CHST5 Gene

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