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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHST4 Gene

protein-coding   GIFtS: 51
GCID: GC16P071560

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase...

 Explore 8 diseases affiliated with
CHST4 via our new
 Human Malady Compendium 
Biological research products
for CHST4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 41 2     HECGLCNAC6ST2
LSST1 2 3     Carbohydrate Sulfotransferase 42
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 32 3     Galactose/N-Acetylglucosamine/N-Acetylgalactosamine 6-O-Sulfotransferase 32
High Endothelial Cells N-Acetylglucosamine 6-O-Sulfotransferase2 3     GlcNAc6ST-23
GST-32 3     Gn6st-23
HEC-GlcNAc6ST2 3     EC 2.8.2.-3
L-Selectin Ligand Sulfotransferase2 3     GlcNAc6ST-23
N-Acetylglucosamine 6-O-Sulfotransferase 22 3     Gn6st-23
HEC-GLCNAC-6-ST1     EC 2.8.28
GST32     EC 2.8.2.178
GlcNAc6ST22     EC 2.8.2.218

External Ids:    HGNC: 19721   Entrez Gene: 101642   Ensembl: ENSG000001408357   UniProtKB: Q8NCG53   

Export aliases for CHST4 gene to outside databases

Previous GC identifers: GC16P062451 GC16P072283 GC16P071295 GC16P071336 GC16P070117 GC16P057328


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHST4:
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from
3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is
localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing
receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same
protein. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: CHST4_HUMAN, Q8NCG5
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated
glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a
central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl
6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by
MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic
preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2),
GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of
GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location

Gene Wiki entry for CHST4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHST4 gene promoter:
         GR   GATA-3   GR-beta   NF-E2 p45   Evi-1   FOXJ2 (long isoform)   HFH-1   FOXJ2   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHST4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22.2

CHST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P071560:  view genomic region     (about GC identifiers)

Start:
71,559,136 bp from pter      End:
71,572,649 bp from pter
Size:
13,514 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHST4_HUMAN, Q8NCG5 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 4  
Size: 386 amino acids; 45134 Da
Subunit: Monomer
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Miscellaneous: May serve as a antiinflammatory target
Sequence caution: Sequence=AAH35282.1; Type=Erroneous initiation;
Secondary accessions: Q8IV46 Q9Y5R3

Explore the universe of human proteins at neXtProt for CHST4: NX_Q8NCG5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NCG5

  • 4/5 DME Specific Peptides for CHST4 (Q8NCG5) (see all 5)
     LVRDPRAV  LHMAVRDL  VVLKEVRF  RSGSSFVGQLF 

    CHST4 Protein expression data from MOPED and PaxDb:    About this image 
    CHST4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001159867.1  NP_005760.1  

    ENSEMBL proteins: 
     ENSP00000341206   ENSP00000441204   ENSP00000461839  

    Human Recombinant Protein Products for CHST4: 
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    OriGene Protein Over-expression Lysate: CHST4
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    Novus Biologicals CHST4 Proteins
    Novus Biologicals CHST4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CHST4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005802trans-Golgi network IDA12855678
    GO:0016021integral to membrane IEA--
    GO:0031228intrinsic to Golgi membrane NAS12855678

    CHST4 for ontologies           About GeneDecksing



    CHST4 Antibody Products: 
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    Uscn ELISAs and CLIAs for CHST4


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CHST4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR016469 Carbohydrate_sulfotransferase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry Q8NCG5

    ProtoNet protein and cluster: Q8NCG5

    UniProtKB/Swiss-Prot: CHST4_HUMAN, Q8NCG5
    Similarity: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHST4_HUMAN, Q8NCG5
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated
    glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a
    central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl
    6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by
    MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic
    preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2),
    GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of
    GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location
    Induction: Upon cytokine activation, it is expressed at low level

         Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.2.172 EC 2.8.2.212 EC 2.8.22

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001517N-acetylglucosamine 6-O-sulfotransferase activity IDA10330415
    GO:0008146sulfotransferase activity TAS10330415
         
    CHST4 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chst4):
     cellular  immune system 

    CHST4 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Chst4tm1Mifu for CHST4
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CHST4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST4
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    hsa-miR-576-3p hsa-miR-485-5p hsa-miR-513a-5p hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidCHST4 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CHST4
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    Sirion Biotech Custom design and validation of potent shRNA sequences against CHST4 

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CHST4 (NM_001166395)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST4 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Keratan sulfate biosynthesis
    Glycosaminoglycan biosynthesis - keratan sulfate0.45
    2Biological oxidations
    metapathway biotransformation0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for CHST4 
        metapathway biotransformation


    1         Kegg Pathway  (Kegg details for CHST4):
        Glycosaminoglycan biosynthesis - keratan sulfate


    CHST4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHST4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CHST4 (ENSP000003412064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD34ENSP000003100364STRING: ENSP00000310036
    DCPSENSP000002635794STRING: ENSP00000263579
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006044N-acetylglucosamine metabolic process IDA10330415
    GO:0006477protein sulfation IEA--
    GO:0006790sulfur compound metabolic process IDA10330415
    GO:0006928cellular component movement TAS10330415

    CHST4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHST4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHST4
    1 Novoseek chemical compound relationship for CHST4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetylglucosamine 51.9 1 16772045 (1)

    Search CenterWatch for drugs/clinical trials and news about CHST4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHST4 gene (2 alternative transcripts): 
    NM_001166395.1  NM_005769.2  

    Unigene Cluster for CHST4:

    Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
    Hs.251383  [show with all ESTs]
    Unigene Representative Sequence: NM_001166395
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338482(uc002fan.3) ENST00000539698(uc002fao.3) ENST00000572450


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST4
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST4:
    hsa-miR-576-3p hsa-miR-485-5p hsa-miR-513a-5p hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidCHST4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHST4 (see all 7)
    OriGene shRNA RFP: CHST4
    OriGene siRNA: CHST4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST4
    Sirion Biotech Custom design and validation of potent shRNA sequences against CHST4 
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CHST4 (NM_001166395)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST4 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHST4
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST4

    Additional cDNA sequence: 

    AF131235.1 AF149783.1 AF280088.1 AK026635.1 AK074746.1 BC035282.1 

    4 DOTS entries:

    DT.75137501  DT.97777913  DT.100745273  DT.120663149 

    20 AceView cDNA sequences:

    BM128370 AK074746 BM969292 BM128831 BI823850 BC035282 AK026635 BU684395 
    AF149783 BM129080 AW572390 NM_005769 AF280088 AW572510 AL709927 AF131235 
    BX490456 AW002418 BF056840 BF878439 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHST4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTGTGTCTA
    CHST4 Expression
    About this image

    CHST4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CHST4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHST4

    SOURCE GeneReport for Unigene cluster: Hs.251383

    UniProtKB/Swiss-Prot: CHST4_HUMAN, Q8NCG5
    Tissue specificity: Specifically expressed in HEV. Weakly expressed in spleen. Not expressed in other tissues.
    Expressed in colonic mucinous adenocarcinoma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHST4 gene from 3/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CHST41 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 less 63.7(n)
    60.11(a)
      427567  XM_425140.2  XP_425140.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHST46
    --
    --
    54(a)
    42(a)
    1 ↔ 1
    possible ortholog
    GL343483.1(281804-282967)
    2(192755869-192757653)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95506
    CG316376
    --
    18(a)
    17(a)
    many ↔ many
    many ↔ many
    2L(6497053-6498455)
    2L(6498642-6526996)


    ENSEMBL Gene Tree for CHST4 (if available)
    TreeFam Gene Tree for CHST4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHST4 gene
    CHST12  CHST22  CHST32  CHST62  CHST72  CHST52  
    6 SIMAP similar genes for CHST4 using alignment to 1 protein entry:     CHST4_HUMAN:
    CHST5    CHST6    CHST2    CHST3    CHST1    CHST7

    CHST4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/221 NCBI SNPs in CHST4 are shown (see all 221    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1122810951,2
    C--57326281(+) TGTACG/AGATTT 2 -- us2k12Minor allele frequency- A:0.02NA 122
    rs798044861,2
    --57326511(+) ACAGAA/GACTGT 2 -- us2k10--------
    rs761898651,2
    --57326705(+) GCTTGG/ACATTC 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs72011891,2
    C,F--57327016(+) gtgtcG/Atgcca 2 -- us2k11Minor allele frequency- A:0.16WA 118
    rs1130625501,2
    C--57327722(+) GGGACT/-CTTTT 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs556767881,2
    C,F--57328191(+) NNNNGT/CGTTAA 2 -- ut51 us2k113Minor allele frequency- C:0.04NA MN 1996
    rs71915091,2
    C--57329285(+) atggcC/Tggtga 2 -- int10--------
    rs1121447921,2
    C--57329516(+) AACCCC/TGTCTG 2 -- int11Minor allele frequency- T:0.50WA 2
    rs606050181,2
    --57329634(+) GAGCCA/GAGATC 2 -- int10--------
    rs285749321,2
    C,F--57330059(+) CCTGAG/CGAGTC 2 -- int13Minor allele frequency- C:0.29WA CSA 122

    HapMap Linkage Disequilibrium report for CHST4 (71559136 - 71572649 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CHST4: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CHST4 for disorders           About GeneDecksing

    8 diseases for CHST4:    About MalaCards
    mucinous adenocarcinoma    colon mucinous adenocarcinoma    rheumatoid arthritis    adenocarcinoma
    arthritis    infertility    cervicitis    immunodeficiency

    1 disease from the University of Copenhagen DISEASES database for CHST4:
    Mucinous adenocarcinoma
    Human Genome Epidemiology (HuGE) Navigator: CHST4 (2 documents)

    Export disorders for CHST4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHST4 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CHST4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. (PubMed id 10330415)1, 2, 3 Bistrup A.... Hemmerich S. (1999)
    2. Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression. (PubMed id 11726653)1, 2, 9 Uchimura K.... Muramatsu T. (2002)
    3. CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. (PubMed id 11310842)1, 2, 9 Li X.... Tedder T.F. (2001)
    4. The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity. (PubMed id 15220337)1, 2 de Graffenried C.L. and Bertozzi C.R. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis. (PubMed id 12855678)1, 2 de Graffenried C.L. and Bertozzi C.R. (2003)
    8. Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma. (PubMed id 12107080)1, 2 Seko A.... Yamashita K. (2002)
    9. Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase. (PubMed id 11439191)1, 2 Yeh J.-C.... Fakuda M. (2001)
    10. Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family. (PubMed id 11181564)1, 2 Hemmerich S....Rosen S.D. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10164 HGNC: 1972 AceView: CHST4 Ensembl:ENSG00000140835 euGenes: HUgn10164
    ECgene: CHST4 Kegg: 10164 H-InvDB: CHST4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHST4 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHST4 gene:
    Search GeneIP for patents involving CHST4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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