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Aliases for CHST3 Gene

Aliases for CHST3 Gene

  • Carbohydrate (Chondroitin 6) Sulfotransferase 3 2 3
  • Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 0 3 4
  • Chondroitin 6-O-Sulfotransferase 1 3 4
  • EC 2.8.2.17 4 63
  • C6ST-1 3 4
  • C6ST1 3 6
  • GST-0 3 4
  • C6ST 3 6
  • HSD 3 6
  • Carbohydrate Sulfotransferase 3 3
  • Chondroitin 6-Sulfotransferase 4
  • EC 2.8.2 63

External Ids for CHST3 Gene

Previous GeneCards Identifiers for CHST3 Gene

  • GC10P072502
  • GC10P072827
  • GC10P073616
  • GC10P073068
  • GC10P073394
  • GC10P073724
  • GC10P067718

Summaries for CHST3 Gene

Entrez Gene Summary for CHST3 Gene

  • This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. [provided by RefSeq, Mar 2009]

GeneCards Summary for CHST3 Gene

CHST3 (Carbohydrate (Chondroitin 6) Sulfotransferase 3) is a Protein Coding gene. Diseases associated with CHST3 include spondyloepiphyseal dysplasia with congenital joint dislocations and larsen syndrome, autosomal recessive. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include sulfotransferase activity and chondroitin 6-sulfotransferase activity. An important paralog of this gene is CHST2.

UniProtKB/Swiss-Prot for CHST3 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST3 Gene

Genomics for CHST3 Gene

Regulatory Elements for CHST3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHST3 Gene

Start:
71,964,362 bp from pter
End:
72,013,564 bp from pter
Size:
49,203 bases
Orientation:
Plus strand

Genomic View for CHST3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST3 Gene

Proteins for CHST3 Gene

  • Protein details for CHST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LGC8-CHST3_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 3
    Protein Accession:
    Q7LGC8
    Secondary Accessions:
    • O75099
    • Q52M30

    Protein attributes for CHST3 Gene

    Size:
    479 amino acids
    Molecular mass:
    54706 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHST3 Gene

Proteomics data for CHST3 Gene at MOPED

Selected DME Specific Peptides for CHST3 Gene

Post-translational modifications for CHST3 Gene

  • Glycosylation at Asn63, Asn74, Asn96, Asn256, Asn420, and Asn464
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CHST3 (Carbohydrate Sulfotransferase 3/CHST3)

Domains for CHST3 Gene

Gene Families for CHST3 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for CHST3 Gene

Suggested Antigen Peptide Sequences for CHST3 Gene

Graphical View of Domain Structure for InterPro Entry

Q7LGC8

UniProtKB/Swiss-Prot:

CHST3_HUMAN :
  • Q7LGC8
Family:
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
genes like me logo Genes that share domains with CHST3: view

Function for CHST3 Gene

Molecular function for CHST3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + chondroitin = adenosine 3,5-bisphosphate + chondroitin 6-sulfate
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.

Enzyme Numbers (IUBMB) for CHST3 Gene

Gene Ontology (GO) - Molecular Function for CHST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity TAS 9883891
GO:0008459 chondroitin 6-sulfotransferase activity IDA 9883891
GO:0050698 proteoglycan sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with CHST3: view
genes like me logo Genes that share phenotypes with CHST3: view

Animal Models for CHST3 Gene

MGI Knock Outs for CHST3:

Animal Model Products

CRISPR Products

miRNA for CHST3 Gene

miRTarBase miRNAs that target CHST3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHST3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CHST3 Gene

Localization for CHST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST3 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST3 Gene COMPARTMENTS Subcellular localization image for CHST3 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CHST3: view

Pathways for CHST3 Gene

genes like me logo Genes that share pathways with CHST3: view

Interacting Proteins for CHST3 Gene

Gene Ontology (GO) - Biological Process for CHST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0005975 carbohydrate metabolic process TAS --
GO:0006790 sulfur compound metabolic process IDA 9883891
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
genes like me logo Genes that share ontologies with CHST3: view

Compounds for CHST3 Gene

(5) HMDB Compounds for CHST3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Chondroitin
  • Chondroitin-D-glucuronate
9007-27-6
Keratan
  • Kerato sulfate
69992-87-6
N-Acetyllactosamine
  • D-galactopyranosyl
32181-59-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(9) Novoseek inferred chemical compound relationships for CHST3 Gene

Compound -log(P) Hits PubMed IDs
chondroitin 91.9 28
3-phosphoadenosine 5-phosphosulfate 87.1 3
keratan sulfate 84.4 5
sulfate 72.3 5
chondroitin sulfate 71.7 2

(2) PharmGKB related drug/compound annotations for CHST3 Gene

Drug/compound Annotation
docetaxel CA
thalidomide CA
genes like me logo Genes that share compounds with CHST3: view

Transcripts for CHST3 Gene

mRNA/cDNA for CHST3 Gene

Unigene Clusters for CHST3 Gene

Carbohydrate (chondroitin 6) sulfotransferase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHST3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CHST3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST3 Gene

No ASD Table

Relevant External Links for CHST3 Gene

GeneLoc Exon Structure for
CHST3
ECgene alternative splicing isoforms for
CHST3

Expression for CHST3 Gene

mRNA expression in normal human tissues for CHST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHST3 Gene

SOURCE GeneReport for Unigene cluster for CHST3 Gene Hs.158304

mRNA Expression by UniProt/SwissProt for CHST3 Gene

Q7LGC8-CHST3_HUMAN
Tissue specificity: Widely expressed in adult tissues. Expressed in heart, placenta, skeletal muscle and pancreas. Also expressed in various immune tissues such as spleen, lymph node, thymus and appendix.
genes like me logo Genes that share expressions with CHST3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CHST3 Gene

Orthologs for CHST3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST3 35
  • 99.79 (n)
  • 100 (a)
CHST3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHST3 35
  • 87.11 (n)
  • 88.24 (a)
CHST3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHST3 35
  • 90.08 (n)
  • 90.57 (a)
CHST3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chst3 35
  • 85.17 (n)
  • 86.65 (a)
Chst3 16
Chst3 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHST3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chst3 35
  • 86.08 (n)
  • 86.29 (a)
chicken
(Gallus gallus)
Aves CHST3 35
  • 80.27 (n)
  • 78.27 (a)
CHST3 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST3 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chst3 35
  • 65.65 (n)
  • 73.91 (a)
zebrafish
(Danio rerio)
Actinopterygii chst3a 36
  • 58 (a)
OneToMany
chst3b 35
  • 69.66 (n)
  • 61.45 (a)
chst3b 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31637 36
  • 18 (a)
ManyToMany
CG9550 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
CSA.5535 36
  • 21 (a)
ManyToMany
Species with no ortholog for CHST3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST3 Gene

ENSEMBL:
Gene Tree for CHST3 (if available)
TreeFam:
Gene Tree for CHST3 (if available)

Paralogs for CHST3 Gene

Paralogs for CHST3 Gene

Selected SIMAP similar genes for CHST3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHST3: view

Variants for CHST3 Gene

Sequence variations from dbSNP and Humsavar for CHST3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs12418 -- 72,013,256(+) TTCAC(A/G)GCATA utr-variant-3-prime
rs730334 -- 71,998,574(+) TCCCC(C/T)ACAGC intron-variant
rs730720 -- 72,013,004(-) ATGGC(A/G)CCATG utr-variant-3-prime
rs730721 -- 72,012,966(-) TTTGT(C/T)CCCAG utr-variant-3-prime
rs730722 -- 72,012,892(-) GTTGC(C/G)AATTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CHST3 Gene

Variant ID Type Subtype PubMed ID
nsv895717 CNV Loss 21882294
nsv895718 CNV Loss 21882294
nsv7110 CNV Insertion 18451855
nsv895719 CNV Loss 21882294
nsv820285 CNV Loss 19587683

Relevant External Links for CHST3 Gene

HapMap Linkage Disequilibrium report
CHST3
Human Gene Mutation Database (HGMD)
CHST3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST3 Gene

Disorders for CHST3 Gene

(1) OMIM Diseases for CHST3 Gene (603799)

UniProtKB/Swiss-Prot

CHST3_HUMAN
  • Spondyloepiphyseal dysplasia with congenital joint dislocations (SEDC-JD) [MIM:143095]: A bone dysplasia clinically characterized by dislocation of the knees and/or hips at birth, clubfoot, elbow joint dysplasia with subluxation and limited extension, short stature, and progressive kyphosis developing in late childhood. The disorder is usually evident at birth, with short stature and multiple joint dislocations or subluxations that dominate the neonatal clinical and radiographic picture. During childhood, the dislocations improve, both spontaneously and with surgical treatment, and features of spondyloepiphyseal dysplasia become apparent, leading to arthritis of the hips and spine with intervertebral disk degeneration, rigid kyphoscoliosis, and trunk shortening by late childhood. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for CHST3 Gene

Relevant External Links for CHST3

Genetic Association Database (GAD)
CHST3
Human Genome Epidemiology (HuGE) Navigator
CHST3
genes like me logo Genes that share disorders with CHST3: view

Publications for CHST3 Gene

  1. Molecular cloning and expression of human chondroitin 6- sulfotransferase. (PMID: 9714738) Fukuta M. … Habuchi O. (Biochim. Biophys. Acta 1998) 2 3 4 23
  2. Functional expression and genomic structure of human chondroitin 6- sulfotransferase. (PMID: 9883891) Tsutsumi K. … Sugahara K. (FEBS Lett. 1998) 2 3 4 23
  3. Loss of chondroitin 6-O-sulfotransferase-1 function results in severe human chondrodysplasia with progressive spinal involvement. (PMID: 15215498) Thiele H. … Mundlos S. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  4. Congenital joint dislocations caused by carbohydrate sulfotransferase 3 deficiency in recessive Larsen syndrome and humero-spinal dysostosis. (PMID: 18513679) Hermanns P. … Superti-Furga A. (Am. J. Hum. Genet. 2008) 3 4 23
  5. Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. (PMID: 18697746) Kitagawa H. … Sugahara K. (J. Biol. Chem. 2008) 3 23

Products for CHST3 Gene

Sources for CHST3 Gene

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