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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHST2 Gene

protein-coding   GIFtS: 55
GCID: GC03P142838

Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase 21 2     Carbohydrate (Chondroitin 6/Keratan) Sulfotransferase 22
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 22 3     Carbohydrate Sulfotransferase 22
GST-22 3     glcNAc6ST-12
Gn6ST-12 3     EC 2.8.2.-3
N-Acetylglucosamine 6-O-Sulfotransferase 12 3     GN6ST3
C6ST2     GlcNAc6ST-13
GST22     

External Ids:    HGNC: 19701   Entrez Gene: 94352   Ensembl: ENSG000001750407   OMIM: 6037985   UniProtKB: Q9Y4C53   

Export aliases for CHST2 gene to outside databases

Previous GC identifers: GC03P139817 GC03P143666 GC03P144119 GC03P144159 GC03P144320 GC03P140210


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHST2 Gene:
This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing
N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. (provided by
RefSeq, Aug 2011)

GeneCards Summary for CHST2 Gene: 
CHST2 (carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2) is a protein-coding gene. Diseases associated with CHST2 include osteonecrosis, and morquio syndrome b, and among its related super-pathways are Keratan sulfate/keratin metabolism and Metabolism of carbohydrates. GO annotations related to this gene include sulfotransferase activity and N-acetylglucosamine 6-O-sulfotransferase activity. An important paralog of this gene is CHST4.

UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like
structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands.
SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites
of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing
to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its
subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains

Gene Wiki entry for CHST2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHST2 gene promoter:
         p53   Nkx2-5   Evi-1   AREB6   SRY   POU2F1   POU2F1b   POU2F1a   Cart-1   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHST2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

CHST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P142838:  view genomic region     (about GC identifiers)

Start:
142,838,173 bp from pter      End:
142,841,812 bp from pter
Size:
3,640 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 2  
Size: 530 amino acids; 57857 Da
Subunit: Homodimer; disulfide-linked. Homodimerization is not essential for enzyme activity
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein
(Probable)
Caution: It is uncertain whether Met-1 or Met-48 is the initiator
Sequence caution: Sequence=BAA34265.2; Type=Erroneous initiation; Sequence=BAB16886.1; Type=Erroneous initiation;
Sequence=BAB16887.1; Type=Erroneous initiation;
Secondary accessions: D3DNG5 Q2M370 Q9GZN5 Q9UED5 Q9Y6F2
Alternative initiation: 2 isoforms:  Q9Y4C5-1   Q9Y4C5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHST2: NX_Q9Y4C5

Explore proteomics data for CHST2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4C5

  • CHST2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHST2 Protein Expression
    REFSEQ proteins: NP_004258.2  
    ENSEMBL proteins: 
     ENSP00000307911  
    Reactome Protein details: Q9Y4C5
    Human Recombinant Protein Products for CHST2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CHST2 (Carbohydrate Sulfotransferase 2/CHST2)
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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals CHST2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHST2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005802trans-Golgi network IDA12855678
    GO:0016021integral to membrane IEA--
    GO:0031228intrinsic to Golgi membrane NAS12855678

    CHST2 for ontologies           About GeneDecksing



    CHST2 Antibody Products: 
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    Assay Products for CHST2: 
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    Cloud-Clone Corp. CLIAs for CHST2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR016469 Carbohydrate_sulfotransferase
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9Y4C5

    ProtoNet protein and cluster: Q9Y4C5

    UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5
    Similarity: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily


    CHST2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHST2_HUMAN, Q9Y4C5
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like
    structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands.
    SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites
    of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing
    to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its
    subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains
    Biophysicochemical properties: Kinetic parameters: KM=3.9 uM for PAPS; KM=1.4 mM for BetaBnO-GlcNAc;
    Induction: Up-regulated upon cytokine activation

         Genatlas biochemistry entry for CHST2:
    chondroitin 6-sulfotransferase key enzyme 2,expressed in vascular endothelial cells,implicated in
    chondrogenesis,neoplasia,atherosclerosis and other

         Enzyme Number (IUBMB): EC 2.8.2.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001517N-acetylglucosamine 6-O-sulfotransferase activity IDA11042394
    GO:0008146sulfotransferase activity TAS9722682
         
    CHST2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chst2):
     cellular  immune system 

    CHST2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Chst2tm1Tmu for CHST2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHST2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHST2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST2 

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST2 (see all 28):
    hsa-miR-30c hsa-miR-502-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-30d hsa-miR-431 hsa-miR-373* hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidCHST2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHST2 About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Keratan sulfate biosynthesis
    Keratan sulfate biosynthesis0.82
    Glycosaminoglycan biosynthesis - keratan sulfate0.43
    Keratan sulfate/keratin metabolism0.82
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    3chondroitin sulfate biosynthesis
    chondroitin sulfate biosynthesis0.74
    chondroitin sulfate biosynthesis (late stages)0.65
    4Biological oxidations
    metapathway biotransformation0.41
    5Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CHST2
        Articular Cartilage Extracellular Matrix


    3 BioSystems Pathways for CHST2
        chondroitin sulfate biosynthesis (late stages)
    metapathway biotransformation
    chondroitin sulfate biosynthesis

    5/18        Reactome Pathways for CHST2 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS II - Hunter syndrome


    1         Kegg Pathway  (Kegg details for CHST2):
        Glycosaminoglycan biosynthesis - keratan sulfate


    CHST2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHST2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for CHST2 (ENSP000003079114) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHST1ENSP000003092704STRING: ENSP00000309270
    LUMENSP000002667184STRING: ENSP00000266718
    ST3GAL1ENSP000003184454STRING: ENSP00000318445
    ST3GAL4ENSP000002274954STRING: ENSP00000227495
    FMODENSP000003470414STRING: ENSP00000347041
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006044N-acetylglucosamine metabolic process IDA9722682
    GO:0006790sulfur compound metabolic process IDA9722682
    GO:0006954inflammatory response IEA--
    GO:0007275multicellular organismal development TAS9722682

    CHST2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHST2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHST2

    3 Novoseek inferred chemical compound relationships for CHST2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 65.7 1 10956661 (1)
    sulfate 64 3 11726653 (1), 15728736 (1)
    n-acetylglucosamine 60.7 1 15728736 (1)

    Search CenterWatch for drugs/clinical trials and news about CHST2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHST2 gene: 
    NM_004267.4  

    Unigene Cluster for CHST2:

    Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
    Hs.8786  [show with all ESTs]
    Unigene Representative Sequence: NM_004267
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000309575(uc003evm.3)
    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST2 (see all 28):
    hsa-miR-30c hsa-miR-502-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-30d hsa-miR-431 hsa-miR-373* hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidCHST2 3' UTR sequence
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    Additional mRNA sequence: 

    AB014679.2 AB014680.2 AB021124.1 AF083066.1 AK023268.1 BC017499.1 BC036930.1 BC042160.1 
    BC068604.1 BC105010.1 BC105012.1 

    3 DOTS entries:

    DT.314882  DT.100690128  DT.97841721 

    24/120 AceView cDNA sequences (see all 120):

    AW732239 BU623278 AI368451 BC017499 AA380245 BF055977 BX109981 AA682637 
    BC068604 AW297253 AB014680 BM713972 BE794921 BC036930 CD515007 BF195119 
    BE208539 BM695999 AA846040 CA390026 AU279547 BQ640043 AI440081 NM_004267 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHST2 expression in normal human tissues (normalized intensities)      CHST2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGTATTAA
    CHST2 Expression
    About this image


    CHST2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/43 selected tissues (see all 43) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             Olfactory Bulb   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Stem Bronchi
             lung ; pneumocytes   
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; endothelial cells   

    See CHST2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHST2

    SOURCE GeneReport for Unigene cluster: Hs.8786

    UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5
    Tissue specificity: Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain,
    spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes

        SABiosciences Custom PCR Arrays for CHST2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHST2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst21 , 5 carbohydrate sulfotransferase 21, 5 87.61(n)1
    94.91(a)1
      9 (50.11 cM)5
    543711  NM_018763.21  NP_061233.21 
     954009295 
    chicken
    (Gallus gallus)
    Aves CHST21 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase more 79.32(n)
    84.62(a)
      429123  XM_003641759.1  XP_003641807.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHST26
    Uncharacterized protein
    75(a)
    1 ↔ 1
    3(21516652-21518668)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX705343.12   -- 79.91(n)    BX705343.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK027941.12   -- 75.3(n)    CK027941.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95506
    CG316376
    --
    18(a)
    17(a)
    many ↔ many
    many ↔ many
    2L(6497053-6498455)
    2L(6498642-6526996)


    ENSEMBL Gene Tree for CHST2 (if available)
    TreeFam Gene Tree for CHST2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHST2 gene
    CHST42  CHST12  CHST32  CHST62  CHST72  CHST52  
    4 SIMAP similar genes for CHST2 using alignment to 1 protein entry:     CHST2_HUMAN:
    CHST7    CHST5    CHST6    CHST4

    CHST2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/142 SNPs in CHST2 are shown (see all 142)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1153886901,2
    F--142814202(+) AAACAA/GTTGTT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1827917511,2
    --142814374(+) CAGTCC/TTTTCA 1 -- us2k10--------
    rs1859471161,2
    --142814415(+) AAAGAA/GGTGGT 1 -- us2k10--------
    rs37557401,2
    C,F,A,H--142814454(-) CCCTTC/TGCCTA 1 -- us2k128Minor allele frequency- T:0.31EA NS NA WA CSA 4237
    rs790595601,2
    F--142814488(+) AAAGAT/CGGGGA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1494449181,2
    --142814521(+) CCTTCA/GTCTGT 1 -- us2k10--------
    rs1438834261,2
    --142814632(+) TCCCCC/TTCCCC 1 -- us2k10--------
    rs1903597331,2
    --142814636(+) CCTCCC/TCAGGA 1 -- us2k10--------
    rs37557391,2
    C,F,H--142814760(-) TTCCAC/TGGGTT 1 -- us2k125Minor allele frequency- T:0.42EA NS NA WA CSA 3642
    rs761201821,2
    F--142814791(+) AAGTCT/CTTGTA 1 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for CHST2 (142838173 - 142841812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CHST2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508250CNV Loss20534489
    nsv877562CNV Gain21882294
    dgv1515e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603798    OMIM disorders: --

    6 diseases for CHST2:    About MalaCards
    osteonecrosis    morquio syndrome b    narcolepsy    endotheliitis
    atherosclerosis    adenocarcinoma


    CHST2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CHST2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 9.42 1 11310842 (1)

    Genetic Association Database (GAD): CHST2
    Human Genome Epidemiology (HuGE) Navigator: CHST2 (5 documents)

    Export disorders for CHST2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHST2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CHST2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. (PubMed id 10049591)1, 2, 3, 9 Li X. and Tedder T.F. (1999)
    2. Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression. (PubMed id 11726653)1, 2, 9 Uchimura K.... Muramatsu T. (2002)
    3. CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. (PubMed id 11310842)1, 2, 9 Li X.... Tedder T.F. (2001)
    4. Functional expression and genomic structure of human N- acetylglucosamine-6-O-sulfotransferase that transfers sulfate to b-N- acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence. (PubMed id 11042394)1, 2, 9 Sakaguchi H.... Sugahara K. (2000)
    5. Role of the carboxyl-terminal region in the activity of N- acetylglucosamine 6-o-sulfotransferase-1. (PubMed id 15632306)1, 2, 9 Chen L.... Muramatsu T. (2004)
    6. Characterization and mutagenesis of Gal/GlcNAc-6-O- sulfotransferases. (PubMed id 12501187)1, 2, 9 Grunwell J.R.... Bertozzi C.R. (2002)
    7. Family-Based Analysis of Genetic Variation Underlying Psychosis-Inducing Effects of Cannabis: Sibling Analysis and Proband Follow-up . (PubMed id 21041608)1, 4 van Winkel R. (2010)
    8. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    9. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    10. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9435 HGNC: 1970 AceView: CHST2 Ensembl:ENSG00000175040 euGenes: HUgn9435
    ECgene: CHST2 Kegg: 9435 H-InvDB: CHST2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHST2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHST2 gene:
    Search GeneIP for patents involving CHST2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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