Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CHST2 Gene

protein-coding   GIFtS: 54
GCID: GC03P142838

Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase...

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase 21 2     Carbohydrate (Chondroitin 6/Keratan) Sulfotransferase 22
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 22 3     Carbohydrate Sulfotransferase 22
GST-22 3     Epididymis Secretory Protein Li 752
Gn6ST-12 3     glcNAc6ST-12
N-Acetylglucosamine 6-O-Sulfotransferase 12 3     EC 2.8.2.-3
C6ST2     GN6ST3
GST22     GlcNAc6ST-13
HEL-S-752     

External Ids:    HGNC: 19701   Entrez Gene: 94352   Ensembl: ENSG000001750407   OMIM: 6037985   UniProtKB: Q9Y4C53   

Export aliases for CHST2 gene to outside databases

Previous GC identifers: GC03P139817 GC03P143666 GC03P144119 GC03P144159 GC03P144320 GC03P140210


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CHST2 Gene:
This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing
N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. (provided by
RefSeq, Aug 2011)

GeneCards Summary for CHST2 Gene:
CHST2 (carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2) is a protein-coding gene. GO annotations related to this gene include sulfotransferase activity and N-acetylglucosamine 6-O-sulfotransferase activity. An important paralog of this gene is CHST4.

UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like
structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands.
SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites
of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing
to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its
subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains

Gene Wiki entry for CHST2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHST2 gene promoter:
         p53   Nkx2-5   Evi-1   AREB6   SRY   POU2F1   POU2F1b   POU2F1a   Cart-1   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST2 promoter sequence
   Search Chromatin IP Primers for CHST2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

CHST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P142838:  view genomic region     (about GC identifiers)

Start:
142,838,173 bp from pter      End:
142,841,812 bp from pter
Size:
3,640 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 2  
Size: 530 amino acids; 57857 Da
Subunit: Homodimer; disulfide-linked. Homodimerization is not essential for enzyme activity
Sequence caution: Sequence=BAA34265.2; Type=Erroneous initiation; Sequence=BAB16886.1; Type=Erroneous initiation;
Sequence=BAB16887.1; Type=Erroneous initiation;
Secondary accessions: D3DNG5 Q2M370 Q9GZN5 Q9UED5 Q9Y6F2
Alternative initiation: 2 isoforms:  Q9Y4C5-1   Q9Y4C5-2   (Higher levels of expression compared to isoform 1 when expressed in HeLa cells. Exhibits similar intracellular GlcNAc-6-O-sulfation activity)

Explore the universe of human proteins at neXtProt for CHST2: NX_Q9Y4C5

Explore proteomics data for CHST2 at MOPED

Post-translational modifications: 

  • Glycosylation at Asn-475 is required for catalytic activity1
  • Glycosylation2 at Asn152, Asn243, Asn457, Asn475

  • See CHST2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004258.2  
    ENSEMBL proteins: 
     ENSP00000307911  
    Reactome Protein details: Q9Y4C5

    CHST2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CHST2 (Carbohydrate Sulfotransferase 2/CHST2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CHST2
    GenScript Custom Purified and Recombinant Proteins Services for CHST2
    Novus Biologicals CHST2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHST2

     
    Search eBioscience for Proteins for CHST2 

     
    antibodies-online proteins for CHST2 (4 products) 

     
    antibodies-online peptides for CHST2

    CHST2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CHST2 (Carbohydrate Sulfotransferase 2/CHST2)
    OriGene Antibodies for CHST2
    OriGene Custom Antibody Services for CHST2
    Novus Biologicals CHST2 Antibodies
    Abcam antibodies for CHST2
    Cloud-Clone Corp. Antibodies for CHST2
    ThermoFisher Antibodies for CHST2
    antibodies-online antibodies for CHST2 (40 products) 

    CHST2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHST2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHST2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHST2
    Cloud-Clone Corp. CLIAs for CHST2
    Search eBioscience for ELISAs for CHST2 
    antibodies-online kits for CHST2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR016469 Carbohydrate_sulfotransferase
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9Y4C5

    ProtoNet protein and cluster: Q9Y4C5

    UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5
    Similarity: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily


    Find genes that share domains with CHST2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHST2_HUMAN, Q9Y4C5
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like
    structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands.
    SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites
    of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing
    to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its
    subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains
    Biophysicochemical properties: Kinetic parameters: KM=3.9 uM for PAPS; KM=1.4 mM for BetaBnO-GlcNAc;
    Induction: Up-regulated upon cytokine activation

         Genatlas biochemistry entry for CHST2:
    chondroitin 6-sulfotransferase key enzyme 2,expressed in vascular endothelial cells,implicated in
    chondrogenesis,neoplasia,atherosclerosis and other

         Enzyme Number (IUBMB): EC 2.8.2.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001517N-acetylglucosamine 6-O-sulfotransferase activity IDA11042394
    GO:0008146sulfotransferase activity TAS9722682
         
    Find genes that share ontologies with CHST2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chst2):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with CHST2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Chst2tm1Tmu for CHST2

       genOway: Develop your customized and physiologically relevant rodent model for CHST2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CHST2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST2 (see all 28):
    hsa-miR-30c hsa-miR-502-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-30d hsa-miR-431 hsa-miR-373* hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidCHST2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHST2
    Predesigned siRNA for gene silencing in human, mouse, rat CHST2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHST2

    Clone
    Products:
         
    OriGene clones in human, mouse for CHST2 (see all 6)
    OriGene ORF clones in mouse, rat for CHST2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHST2 (NM_004267)
    Sino Biological Human cDNA Clone for CHST2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHST2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHST2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CHST2_HUMAN, Q9Y4C5: Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    mitochondrion2
    cytoskeleton1
    cytosol1
    extracellular1
    lysosome1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005802trans-Golgi network IDA12855678
    GO:0016021integral component of membrane IEA--
    GO:0031228intrinsic component of Golgi membrane NAS12855678

    Find genes that share ontologies with CHST2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CHST2 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Keratan sulfate/keratin metabolism
    Keratan sulfate/keratin metabolism0.85
    Glycosaminoglycan biosynthesis - keratan sulfate0.43
    Keratan sulfate biosynthesis0.85
    3Biological oxidations
    metapathway biotransformation0.42
    4Metabolism
    Metabolism0.38
    5Disease
    Disease


    Find genes that share SuperPaths with CHST2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CHST2
        Articular Cartilage Extracellular Matrix


    3 BioSystems Pathways for CHST2
        chondroitin sulfate biosynthesis (late stages)
    metapathway biotransformation
    chondroitin sulfate biosynthesis


    1 Reactome Pathway for CHST2
        Keratan sulfate biosynthesis


    1 Kegg Pathway  (Kegg details for CHST2):
        Glycosaminoglycan biosynthesis - keratan sulfate

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHST2
    Interactions:

        Search GeneGlobe Interaction Network for CHST2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for CHST2 (ENSP000003079114) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHST1ENSP000003092704STRING: ENSP00000309270
    LUMENSP000002667184STRING: ENSP00000266718
    ST3GAL1ENSP000003184454STRING: ENSP00000318445
    ST3GAL3ENSP000002629154STRING: ENSP00000262915
    ST3GAL4ENSP000002274954STRING: ENSP00000227495
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006044N-acetylglucosamine metabolic process IDA9722682
    GO:0006790sulfur compound metabolic process IDA9722682
    GO:0006954inflammatory response IEA--
    GO:0007275multicellular organismal development TAS9722682

    Find genes that share ontologies with CHST2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHST2

    3 Novoseek inferred chemical compound relationships for CHST2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 65.7 1 10956661 (1)
    sulfate 64 3 11726653 (1), 15728736 (1)
    n-acetylglucosamine 60.7 1 15728736 (1)



    Find genes that share compounds with CHST2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CHST2 gene: 
    NM_004267.4  

    Unigene Cluster for CHST2:

    Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
    Hs.8786  [show with all ESTs]
    Unigene Representative Sequence: NM_004267
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000309575(uc003evm.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHST2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST2 (see all 28):
    hsa-miR-30c hsa-miR-502-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-30d hsa-miR-431 hsa-miR-373* hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidCHST2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHST2
    Predesigned siRNA for gene silencing in human, mouse, rat CHST2
    Clone
    Products:
         
    OriGene clones in human, mouse for CHST2 (see all 6)
    OriGene ORF clones in mouse, rat for CHST2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHST2 (NM_004267)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHST2
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST2
      QuantiTect SYBR Green Assays in human, mouse, rat CHST2
      QuantiFast Probe-based Assays in human, mouse, rat CHST2

    Additional mRNA sequence: 

    AB014679.2 AB014680.2 AB021124.1 AF083066.1 AK023268.1 BC017499.1 BC036930.1 BC042160.1 
    BC068604.1 BC105010.1 BC105012.1 

    3 DOTS entries:

    DT.314882  DT.100690128  DT.97841721 

    Selected AceView cDNA sequences (see all 120):

    H89886 AI440081 AI784543 NM_004267 BC042160 AB014679 BQ637965 BF195119 
    T35895 CA390026 AA682637 BC017499 BM713972 BG056606 AA380245 BM695999 
    BF055977 BU623278 BC036930 BE208539 AF083066 AU279547 AI797262 AW297253 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CHST2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGTATTAA
    CHST2 Expression
    About this image


    CHST2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
    CHST2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHST2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8786

    UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5
    Tissue specificity: Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain,
    spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes

        Custom PCR Arrays for CHST2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHST2
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST2
    QuantiTect SYBR Green Assays in human, mouse, rat CHST2
    QuantiFast Probe-based Assays in human, mouse, rat CHST2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CHST2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst21 , 5 carbohydrate sulfotransferase 21, 5 87.61(n)1
    94.91(a)1
      9 (50.11 cM)5
    543711  NM_018763.21  NP_061233.21 
     954009295 
    chicken
    (Gallus gallus)
    Aves CHST21 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase more 81.65(n)
    87.74(a)
      429123  XM_003641759.2  XP_003641807.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHST26
    carbohydrate (N-acetylglucosamine-6-O) sulfotransf...
    77(a)
    1 ↔ 1
    3(21516652-21518668)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX705343.12   -- 79.91(n)    BX705343.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK027941.12   -- 75.3(n)    CK027941.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95506
    CG316376
    --
    20(a)
    19(a)
    many ↔ many
    many ↔ many
    2L(6497053-6498455)
    2L(6498642-6526996)


    ENSEMBL Gene Tree for CHST2 (if available)
    TreeFam Gene Tree for CHST2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CHST2 gene
    CHST42  CHST12  CHST32  CHST62  CHST72  CHST52  
    4 SIMAP similar genes for CHST2 using alignment to 1 protein entry:     CHST2_HUMAN:
    CHST7    CHST5    CHST6    CHST4

    Find genes that share paralogs with CHST2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CHST2 (see all 142)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1153886901,2
    F--142814202(+) AAACAA/GTTGTT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1827917511,2
    --142814374(+) CAGTCC/TTTTCA 1 -- us2k10--------
    rs1859471161,2
    --142814415(+) AAAGAA/GGTGGT 1 -- us2k10--------
    rs37557401,2
    C,F,A,H--142814454(-) CCCTTC/TGCCTA 1 -- us2k128Minor allele frequency- T:0.31EA NS NA WA CSA 4237
    rs790595601,2
    F--142814488(+) AAAGAT/CGGGGA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1494449181,2
    --142814521(+) CCTTCA/GTCTGT 1 -- us2k10--------
    rs1438834261,2
    --142814632(+) TCCCCC/TTCCCC 1 -- us2k10--------
    rs1903597331,2
    --142814636(+) CCTCCC/TCAGGA 1 -- us2k10--------
    rs37557391,2
    C,F,H--142814760(-) TTCCAC/TGGGTT 1 -- us2k125Minor allele frequency- T:0.42EA NS NA WA CSA 3642
    rs761201821,2
    F--142814791(+) AAGTCT/CTTGTA 1 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for CHST2 (142838173 - 142841812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CHST2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508250CNV Loss20534489
    nsv877562CNV Gain21882294
    dgv1515e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHST2
    DNA2.0 Custom Variant and Variant Library Synthesis for CHST2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603798    OMIM disorders: --


    Find genes that share disorders with CHST2           About GenesLikeMe

    1 Novoseek inferred disease relationship for CHST2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 9.42 1 11310842 (1)

    Genetic Association Database (GAD): CHST2
    Human Genome Epidemiology (HuGE) Navigator: CHST2 (5 documents)

    Export disorders for CHST2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CHST2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CHST2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. (PubMed id 10049591)1, 2, 3, 9 Li X. and Tedder T.F. (Genomics 1999)
    2. Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression. (PubMed id 11726653)1, 2, 9 Uchimura K.... Muramatsu T. (J. Biol. Chem. 2002)
    3. CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. (PubMed id 11310842)1, 2, 9 Li X.... Tedder T.F. (J. Leukoc. Biol. 2001)
    4. Functional expression and genomic structure of human N- acetylglucosamine-6-O-sulfotransferase that transfers sulfate to b-N- acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence. (PubMed id 11042394)1, 2, 9 Sakaguchi H.... Sugahara K. (Biochim. Biophys. Acta 2000)
    5. Effects of N-glycosylation on the activity and localization of GlcNAc-6-sulfotransferase 1. (PubMed id 19571171)1, 2, 9 Desko M.M....Kohler J.J. (Glycobiology 2009)
    6. Role of the carboxyl-terminal region in the activity of N- acetylglucosamine 6-o-sulfotransferase-1. (PubMed id 15632306)1, 2, 9 Chen L.... Muramatsu T. (J. Biochem. 2004)
    7. Characterization and mutagenesis of Gal/GlcNAc-6-O- sulfotransferases. (PubMed id 12501187)1, 2, 9 Grunwell J.R.... Bertozzi C.R. (Biochemistry 2002)
    8. Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. (PubMed id 21041608)1, 4 van Winkel R. (Arch. Gen. Psychiatry 2011)
    9. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    10. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9435 HGNC: 1970 AceView: CHST2 Ensembl:ENSG00000175040 euGenes: HUgn9435
    ECgene: CHST2 Kegg: 9435 H-InvDB: CHST2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CHST2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=CHST2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CHST2 gene:
    Search GeneIP for patents involving CHST2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CHST2 (Carbohydrate Sulfotransferase 2/CHST2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for CHST2 (Carbohydrate Sulfotransferase 2/CHST2)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CHST2   OriGene RNAi products in human, mouse, rat for CHST2  
     OriGene qPCR primer pairs and template standards for CHST2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CHST2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHST2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CHST2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHST2   OriGene Custom Protein Services for CHST2  

     
     
     Block miRNA regulation of human, mouse, rat CHST2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CHST2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHST2 Predesigned siRNA for gene silencing in human, mouse, rat CHST2
     QuantiFast Probe-based Assays in human, mouse, rat CHST2 QuantiTect SYBR Green Assays in human, mouse, rat CHST2
     Custom PCR Arrays for CHST2 Search Chromatin IP Primers for CHST2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST2  Search GeneGlobe Interaction Network for CHST2
     Regulatory tfbs in CHST2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CHST2 GenScript cDNA clones with any tag delivered in your preferred vector for CHST2
     GenScript Custom Assay Services for CHST2 GenScript Custom overexpressing Cell Line Services for CHST2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CHST2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CHST2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CHST2 antibodies
     CHST2 proteins
     Antibodies for CHST2
     See all of Abcam's Antibodies, Kits and Proteins for CHST2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CHST2
     Antibodies for CHST2
     ELISAs for CHST2
     CLIAs for CHST2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CHST2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST2
     SwitchGear 3'UTR luciferase reporter plasmids for CHST2
     SwitchGear Promoter luciferase reporter plasmids for CHST2
     ThermoFisher Antibodies for CHST2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST2
     Browse compounds at ApexBio
     Search Addgene for plasmids for CHST2
      Search eBioscience for proteins for CHST2
      Search eBioscience for elisas for CHST2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CHST2
     antibodies-online antibodies for CHST2 (40 products)
     antibodies-online kits for CHST2 (4 products)
     antibodies-online peptides for CHST2
     antibodies-online proteins for CHST2 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHST2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4