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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CHST2 Gene

protein-coding GIFtS: 54
GCID: GC03P142838

carbohydrate (N-acetylglucosamine-6-O) sulfotransferase...

Explore 5 diseases affiliated with
CHST2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase 2¹ ²		Carbohydrate (Chondroitin 6/Keratan) Sulfotransferase 2²
C6ST¹ ²		Carbohydrate Sulfotransferase 2²
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 2² ³		GlcNAc6ST-1³
GST-2² ³		EC 2.8.2.-³
Gn6ST-1² ³		GN6ST³
N-Acetylglucosamine 6-O-Sulfotransferase 1² ³		GlcNAc6ST-1³
GST2²

External Ids:	HGNC: 1970¹	Entrez Gene: 9435²	Ensembl: ENSG00000175040⁷	OMIM: 603798⁵	UniProtKB: Q9Y4C5³

Export aliases for CHST2 gene to outside databases

Previous GC identifers: GC03P139817 GC03P143666 GC03P144119 GC03P144159 GC03P144320 GC03P140210

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHST2:

This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing

N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. (provided by

RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the

transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures

on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are

present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.

Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has

no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates

GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains

Gene Wiki entry for CHST2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CHST2 gene promoter:
p53 Nkx2-5 Evi-1 AREB6 SRY POU2F1 POU2F1b POU2F1a Cart-1 POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHST2 promoter sequence

Search SABiosciences Chromatin IP Primers for CHST2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24 Ensembl cytogenetic band: 3q24 HGNC cytogenetic band: 3q24

CHST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST2 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P142838: view genomic region (about GC identifiers)

Start:	142,838,173 bp from pter	End:	142,841,812 bp from pter
Size:	3,640 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5 (See protein sequence)

Recommended Name: Carbohydrate sulfotransferase 2

Size: 530 amino acids; 57857 Da

Subunit: Homodimer; disulfide-linked. Homodimerization is not essential for enzyme activity

Subcellular location: Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein (Probable)

Caution: It is uncertain whether Met-1 or Met-48 is the initiator

Sequence caution: Sequence=BAA34265.2; Type=Erroneous initiation; Sequence=BAB16886.1; Type=Erroneous initiation;

Sequence=BAB16887.1; Type=Erroneous initiation;

Secondary accessions: D3DNG5 Q2M370 Q9GZN5 Q9UED5 Q9Y6F2

Alternative initiation: 2 isoforms: Q9Y4C5-1 Q9Y4C5-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHST2: NX_Q9Y4C5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y4C5

CHST2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004258.2

ENSEMBL proteins:

ENSP00000307911

Reactome Protein details: Q9Y4C5
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CHST2 (Carbohydrate Sulfotransferase 2/CHST2)
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	GenScript Custom Purified and Recombinant Proteins Services for CHST2
	Novus Biologicals CHST2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CHST2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005802	trans-Golgi network	IDA	12855678
GO:0016021	integral to membrane	IEA	--
GO:0031228	intrinsic to Golgi membrane	NAS	12855678

CHST2 for ontologies About GeneDecksing

CHST2 Antibody Products:

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	GenScript Custom Superior Antibodies Services for CHST2
	Novus Biologicals CHST2 Antibodies
	Search for Antibodies for CHST2 at Abcam
	Uscn Antibodies for CHST2
	ThermoFisher Antibodies for CHST2

Assay Products for CHST2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CHST2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CHST2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CHST2 for domains About GeneDecksing

2 InterPro domains/families:

IPR016469 Carbohydrate_sulfotransferase

IPR000863 Sulfotransferase_dom

Graphical View of Domain Structure for InterPro Entry Q9Y4C5

ProtoNet protein and cluster: Q9Y4C5

UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5

Similarity: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the

transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures

on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are

present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.

Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has

no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates

GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains

Biophysicochemical properties: Kinetic parameters: KM=3.9 uM for PAPS; KM=1.4 mM for BetaBnO-GlcNAc;

Induction: Up-regulated upon cytokine activation

Genatlas biochemistry entry for CHST2:

chondroitin 6-sulfotransferase key enzyme 2,expressed in vascular endothelial cells,implicated in

chondrogenesis,neoplasia,atherosclerosis and other

Enzyme Number (IUBMB): EC 2.8.2.-¹

miRNA Products:		OriGene 3'-UTR Clone: CHST2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST2
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST2 (see all 28):
		hsa-miR-30c hsa-miR-502-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-30d hsa-miR-431 hsa-miR-373* hsa-miR-3680

		SwitchGear 3'UTR luciferase reporter plasmid: CHST2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHST2 (see all 4) OriGene shRNA RFP: CHST2 OriGene siRNA: CHST2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CHST2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHST2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHST2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHST2 (NM_004267)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CHST2
		Search LifeMap BioReagents cell lines for CHST2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity	IDA	11042394
GO:0008146	sulfotransferase activity	TAS	9722682

CHST2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Chst2^tm1Tmu for CHST2
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Chst2):

cellular

immune system

CHST2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/14 pathways (see all 14)
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS I - Hurler syndrome	1.00	MPS IIID - Sanfilippo syndrome D	1.00
Mucopolysaccharidoses	1.00	MPS IX - Natowicz syndrome	1.00
MPS IV - Morquio syndrome A	1.00	MPS II - Hunter syndrome	1.00

Keratan sulfate biosynthesis

	Keratan sulfate biosynthesis	1.00			Glycosaminoglycan biosynthesis - keratan sulfate	0.45
	Keratan sulfate/keratin metabolism	0.84

dermatan sulfate biosynthesis

chondroitin sulfate biosynthesis

0.64

chondroitin sulfate biosynthesis (late stages)

0.32

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for CHST2

Articular Cartilage Extracellular Matrix

3 BioSystems Pathways for CHST2

	chondroitin sulfate biosynthesis (late stages)
	metapathway biotransformation
	chondroitin sulfate biosynthesis

5/18 Reactome Pathways for CHST2 (see all 18)

	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	Keratan sulfate/keratin metabolism
	MPS II - Hunter syndrome

1 Kegg Pathway (Kegg details for CHST2):

Glycosaminoglycan biosynthesis - keratan sulfate

CHST2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CHST2

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/13 Interacting proteins for CHST2 (ENSP00000307911⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHST1	ENSP00000309270⁴	STRING: ENSP00000309270
LUM	ENSP00000266718⁴	STRING: ENSP00000266718
ST3GAL1	ENSP00000318445⁴	STRING: ENSP00000318445
ST3GAL4	ENSP00000227495⁴	STRING: ENSP00000227495
FMOD	ENSP00000347041⁴	STRING: ENSP00000347041

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006044	N-acetylglucosamine metabolic process	IDA	9722682
GO:0006790	sulfur compound metabolic process	IDA	9722682
GO:0006954	inflammatory response	IEA	--
GO:0007275	multicellular organismal development	TAS	9722682

CHST2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CHST2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CHST2
3 Novoseek chemical compound relationships for CHST2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chondroitin	65.7	1	10956661 (1)
sulfate	64	3	11726653 (1), 15728736 (1)
n-acetylglucosamine	60.7	1	15728736 (1)

Search CenterWatch for drugs/clinical trials and news about CHST2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CHST2 gene:

NM_004267.4

Unigene Cluster for CHST2:

Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2

Hs.744216 [show with all ESTs]

Unigene Representative Sequence: NM_004267

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000309575(uc003evm.3)

miRNA Products:		OriGene 3'-UTR Clone: CHST2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST2
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST2 (see all 28):
		hsa-miR-30c hsa-miR-502-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-30d hsa-miR-431 hsa-miR-373* hsa-miR-3680

		SwitchGear 3'UTR luciferase reporter plasmid: CHST2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHST2 (see all 4) OriGene shRNA RFP: CHST2 OriGene siRNA: CHST2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHST2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHST2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHST2 (NM_004267)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST2

Additional cDNA sequence:

AB014679.2 AB014680.2 AB021124.1 AF083066.1 AK023268.1 BC017499.1 BC036930.1 BC042160.1

BC068604.1 BC105010.1 BC105012.1

2 DOTS entries:

DT.314882 DT.100690128

24/120 AceView cDNA sequences (see all 120):

AA380245 AA682637 BF477523 BM713972 AI440081 BX109981 AK023268 AW732239

BC068604 BQ640043 NM_004267 BF055977 AW297253 BC017499 T35895 AW026423

CD515007 BI835881 AA846040 BM695999 AB014679 BE208539 BQ637965 AI368451

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CHST2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGTATTAA

About this image

CHST2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CHST2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHST2

SOURCE GeneReport for Unigene cluster: Hs.744216

UniProtKB/Swiss-Prot: CHST2_HUMAN, Q9Y4C5

Tissue specificity: Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain,

spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes

SABiosciences Custom PCR Arrays for CHST2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CHST2 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CHST2¹	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase more	79.32(n) 84.62(a)		429123 XM_003641759.1 XP_003641807.1
lizard (Anolis carolinensis)	Reptilia	CHST2⁶	--	74(a)	1 ↔ 1	3(21516652-21518668)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX705343.1²	--	79.91(n)		BX705343.1
zebrafish (Danio rerio)	Actinopterygii	CK027941.1²	--	75.3(n)		CK027941.1
fruit fly (Drosophila melanogaster)	Insecta	CG31637⁶ CG9550⁶	--	19(a) 18(a)	many ↔ many many ↔ many	2L(6498642-6526996) 2L(6497053-6498455)

ENSEMBL Gene Tree for CHST2 (if available)
TreeFam Gene Tree for CHST2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CHST2 gene

CHST4² CHST1² CHST3² CHST6² CHST7² CHST5²

4 SIMAP similar genes for CHST2 using alignment to 1 protein entry: CHST2_HUMAN:

CHST7 CHST5 CHST6 CHST4

CHST2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79059560^1,2	F,	--	140209265(+)	`AAAGAT/CGGGGA`	1	--	us2k¹		1		WA	118
rs76120182^1,2		--	140209568(+)	`AAGTCT/CTTGTA`	1	--	us2k¹		1		WA	118
rs79227864^1,2	F,	--	140209675(+)	`CAAAGA/GTAATT`	1	--	us2k¹		1		WA	118
rs112633558^1,2		--	140209800(+)	`GGCACC/TTGGAG`	1	--	us2k¹		1		CSA	2
rs58870624^1,2	C,F,	--	140209880(+)	`GTTACA/GACTGT`	1	--	us2k¹		1		WA	118
rs73868248^1,2	C,F,	--	140209970(+)	`TTCCTC/TATAAC`	1	--	us2k¹		3		WA CSA	122
rs11549674^1,2	C,F,H	--	140211019(+)	`AAGCGC/TTGGTA`	1	--	ut5¹ ese³		6		NS NA	800
rs72551381^1,2		--	140211478(+)	`AGGGCG/TCCCGC`	1	--	ut5¹		0	--	--	--	--
rs6764683^1,2	C,	--	140211543(+)	`GCGGGG/TACCCC`	1	--	ut5¹ ese³		2		CSA WA	120
rs4149494^1,2	C,A,	--	140211811(+)	`CGCCGC/TGCCCG`	1	--	ut5¹ ese³		3		NA WA EA	240

HapMap Linkage Disequilibrium report for CHST2 (142838173 - 142841812 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CHST2
1 CNV: 3452

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CHST2 for disorders           About GeneDecksing

OMIM gene information: 603798    OMIM disorders: --

5 diseases for CHST2:    About MalaCards

hearing loss osteonecrosis atherosclerosis immunodeficiency

adenocarcinoma

1 Novoseek disease relationship for CHST2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	9.42	1	11310842 (1)

Human Genome Epidemiology (HuGE) Navigator: CHST2 (5 documents)

Export disorders for CHST2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CHST2 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with CHST2)

Utopia: connect your pdf to the dynamic
world of online information

CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. (PubMed id 10049591)^{1, 2, 3, 9} Li X. and Tedder T.F. (1999)
Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression. (PubMed id 11726653)^{1, 2, 9} Uchimura K.... Muramatsu T. (2002)
CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. (PubMed id 11310842)^{1, 2, 9} Li X.... Tedder T.F. (2001)
Functional expression and genomic structure of human N- acetylglucosamine-6-O-sulfotransferase that transfers sulfate to b-N- acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence. (PubMed id 11042394)^{1, 2, 9} Sakaguchi H.... Sugahara K. (2000)
Role of the carboxyl-terminal region in the activity of N- acetylglucosamine 6-o-sulfotransferase-1. (PubMed id 15632306)^{1, 2, 9} Chen L.... Muramatsu T. (2004)
Characterization and mutagenesis of Gal/GlcNAc-6-O- sulfotransferases. (PubMed id 12501187)^{1, 2, 9} Grunwell J.R.... Bertozzi C.R. (2002)
The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity. (PubMed id 15220337)^{1, 2} de Graffenried C.L. and Bertozzi C.R. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis. (PubMed id 12855678)^{1, 2} de Graffenried C.L. and Bertozzi C.R. (2003)
Human N-acetylglucosamine-6-O-sulfotransferase involved in the biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning, chromosomal mapping, and expression in various organs and tumor cells. (PubMed id 9722682)^{1, 2} Uchimura K.... Muramatsu T. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9435	HGNC: 1970	AceView: CHST2	Ensembl:ENSG00000175040	euGenes: HUgn9435
ECgene: CHST2	Kegg: 9435	H-InvDB: CHST2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CHST2	Pharmacogenomics, SNPs, Pathways
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/

Intellectual Property for CHST2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CHST2 gene:
Search GeneIP for patents involving CHST2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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