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Aliases for CHST15 Gene

Aliases for CHST15 Gene

  • Carbohydrate (N-Acetylgalactosamine 4-Sulfate 6-O) Sulfotransferase 15 2 3
  • BRAG 3 4 6
  • N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase 2 4
  • B-Cell RAG-Associated Gene Protein 3 4
  • GALNAC4S-6ST 3 4
  • KIAA0598 4 6
  • HBRAG 3 4
  • B Cell RAG Associated Protein (GALNAC4S-6ST) 3
  • Carbohydrate Sulfotransferase 15 3
  • B Cell RAG Associated Protein 2
  • GALNAC4S6ST 4
  • EC 2.8.2.33 4

External Ids for CHST15 Gene

Summaries for CHST15 Gene

Entrez Gene Summary for CHST15 Gene

  • Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for CHST15 Gene

CHST15 (Carbohydrate (N-Acetylgalactosamine 4-Sulfate 6-O) Sulfotransferase 15) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include 3-phosphoadenosine 5-phosphosulfate binding and N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity.

UniProtKB/Swiss-Prot for CHST15 Gene

  • Sulfotransferase that transfers sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo.

Gene Wiki entry for CHST15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST15 Gene

Genomics for CHST15 Gene

Genomic Location for CHST15 Gene

Start:
124,006,155 bp from pter
End:
124,093,684 bp from pter
Size:
87,530 bases
Orientation:
Minus strand

Genomic View for CHST15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHST15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST15 Gene

No data available for Regulatory Elements for CHST15 Gene

Proteins for CHST15 Gene

  • Protein details for CHST15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LFX5-CHSTF_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 15
    Protein Accession:
    Q7LFX5
    Secondary Accessions:
    • O60338
    • O60474
    • Q86VM4

    Protein attributes for CHST15 Gene

    Size:
    561 amino acids
    Molecular mass:
    64926 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Cofactor:
    Name=glutathione; Xref=ChEBI:CHEBI:57925;
    Quaternary structure:
    • Homodimer; disulfide-linked (Potential). The relevance of homodimerization is however unsure. May interact with phosphorylated proteins in resting B-cells, including HCK.
    SequenceCaution:
    • Sequence=AAC71691.1; Type=Frameshift; Positions=180, 223, 489, 537; Evidence={ECO:0000305}; Sequence=AAH50540.1; Type=Frameshift; Positions=511; Evidence={ECO:0000305}; Sequence=BAA25524.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHST15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHST15 Gene

Proteomics data for CHST15 Gene at MOPED

Post-translational modifications for CHST15 Gene

Other Protein References for CHST15 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHST15 Gene

Domains for CHST15 Gene

Gene Families for CHST15 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for CHST15 Gene

Graphical View of Domain Structure for InterPro Entry

Q7LFX5

UniProtKB/Swiss-Prot:

CHSTF_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family.:
    • Q7LFX5
genes like me logo Genes that share domains with CHST15: view

Function for CHST15 Gene

Molecular function for CHST15 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetylgalactosamine = adenosine 3,5-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine.
UniProtKB/Swiss-Prot CatalyticActivity: 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetylgalactosamine = adenosine 3,5-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by phenyl beta-GalNAc(4,6-SO(4)).
UniProtKB/Swiss-Prot Function: Sulfotransferase that transfers sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo.

Enzyme Numbers (IUBMB) for CHST15 Gene

Gene Ontology (GO) - Molecular Function for CHST15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity --
GO:0050656 3-phosphoadenosine 5-phosphosulfate binding IDA 11572857
GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IDA 11572857
genes like me logo Genes that share ontologies with CHST15: view

Phenotypes for CHST15 Gene

genes like me logo Genes that share phenotypes with CHST15: view

Animal Models for CHST15 Gene

MGI Knock Outs for CHST15:

miRNA for CHST15 Gene

miRTarBase miRNAs that target CHST15

No data available for Transcription Factor Targeting and HOMER Transcription for CHST15 Gene

Localization for CHST15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST15 Gene

Golgi apparatus membrane; Single-pass type II membrane protein. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST15 Gene COMPARTMENTS Subcellular localization image for CHST15 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHST15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane NAS 11572857
genes like me logo Genes that share ontologies with CHST15: view

Pathways for CHST15 Gene

genes like me logo Genes that share pathways with CHST15: view

Gene Ontology (GO) - Biological Process for CHST15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0019319 hexose biosynthetic process IDA 11572857
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHST15: view

Compounds for CHST15 Gene

(5) HMDB Compounds for CHST15 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Chondroitin
  • Chondroitin-D-glucuronate
9007-27-6
Chondroitin 4-sulfate
  • Chondroitin 4'-sulfate
Not Available
Dermatan
  • Chondroitin sulfate B
24967-94-0
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(5) Novoseek inferred chemical compound relationships for CHST15 Gene

Compound -log(P) Hits PubMed IDs
n-acetylgalactosamine 4-sulfate 99.3 9
3-phosphoadenosine 5-phosphosulfate 88.9 6
chondroitin sulfate 80.3 8
dermatan sulfate 71.7 5
sulfate 70 12
genes like me logo Genes that share compounds with CHST15: view

Transcripts for CHST15 Gene

Unigene Clusters for CHST15 Gene

Carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHST15 Gene

No ASD Table

Relevant External Links for CHST15 Gene

GeneLoc Exon Structure for
CHST15
ECgene alternative splicing isoforms for
CHST15

Expression for CHST15 Gene

mRNA expression in normal human tissues for CHST15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST15 Gene

This gene is overexpressed in Whole Blood (11.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHST15 Gene

SOURCE GeneReport for Unigene cluster for CHST15 Gene Hs.287537

mRNA Expression by UniProt/SwissProt for CHST15 Gene

Q7LFX5-CHSTF_HUMAN
Tissue specificity: Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B, pre-B, and mature B-cell lines, it colocalizes with RAG1.
genes like me logo Genes that share expressions with CHST15: view

Orthologs for CHST15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHST15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST15 35
  • 99.58 (n)
  • 99.47 (a)
CHST15 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHST15 35
  • 89.42 (n)
  • 90.55 (a)
CHST15 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHST15 35
  • 88.29 (n)
  • 91.44 (a)
CHST15 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chst15 35
  • 86.39 (n)
  • 92.51 (a)
Chst15 16
Chst15 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHST15 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHST15 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chst15 35
  • 87.05 (n)
  • 92.51 (a)
chicken
(Gallus gallus)
Aves CHST15 35
  • 73.64 (n)
  • 78.53 (a)
CHST15 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST15 36
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CHST15 36
  • 56 (a)
OneToOne
LOC565523 35
  • 60.65 (n)
  • 57.84 (a)
Species with no ortholog for CHST15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST15 Gene

ENSEMBL:
Gene Tree for CHST15 (if available)
TreeFam:
Gene Tree for CHST15 (if available)

Paralogs for CHST15 Gene

No data available for Paralogs for CHST15 Gene

Variants for CHST15 Gene

Sequence variations from dbSNP and Humsavar for CHST15 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs10899 -- 124,008,704(-) CCGTC(C/T)ACCCA utr-variant-3-prime, intron-variant
rs12915 -- 124,008,578(-) CGTTC(A/C/G)AAGGT utr-variant-3-prime, intron-variant
rs1801819 -- 124,008,486(-) GGACA(A/G)TCCCC utr-variant-3-prime, intron-variant
rs3936165 -- 124,081,302(-) GAAAC(A/G)CTGAG intron-variant
rs4072194 -- 124,021,243(-) CCCCC(C/G/T)CCCCC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CHST15 Gene

Variant ID Type Subtype PubMed ID
nsv524333 CNV Loss 19592680
esv2742617 CNV Deletion 23290073
esv33043 CNV Loss 17666407

Relevant External Links for CHST15 Gene

HapMap Linkage Disequilibrium report
CHST15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST15 Gene

Disorders for CHST15 Gene

Relevant External Links for CHST15

Genetic Association Database (GAD)
CHST15
Human Genome Epidemiology (HuGE) Navigator
CHST15
genes like me logo Genes that share disorders with CHST15: view

No data available for UniProtKB/Swiss-Prot for CHST15 Gene

Publications for CHST15 Gene

  1. Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene. (PMID: 11572857) Ohtake S. … Habuchi O. (J. Biol. Chem. 2001) 2 3 4 23
  2. Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells. (PMID: 10749872) Verkoczy L.K. … Berinstein N.L. (J. Biol. Chem. 2000) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  4. hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1). (PMID: 9754571) Verkoczy L.K. … Berinstein N.L. (Eur. J. Immunol. 1998) 2 3 4
  5. A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase. (PMID: 12874280) Ohtake S. … Habuchi O. (J. Biol. Chem. 2003) 3 4 23

Products for CHST15 Gene

Sources for CHST15 Gene

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