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CHST15 Gene

protein-coding   GIFtS: 59
GCID: GC10M125759

Carbohydrate (N-Acetylgalactosamine 4-Sulfate 6-O) Sulfotransferase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbohydrate (N-Acetylgalactosamine 4-Sulfate 6-O) Sulfotransferase
151 2
     GALNAC4S-6ST2
BRAG2 3 5     B Cell RAG Associated Protein (GALNAC4S-6ST)2
N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase1 3     Carbohydrate Sulfotransferase 152
B-Cell RAG-Associated Gene Protein2 3     EC 2.8.2.333
hBRAG2 3     GALNAC4S6ST3
KIAA05983 5     GalNAc4S-6ST3
B Cell RAG Associated Protein1     

External Ids:    HGNC: 181371   Entrez Gene: 513632   Ensembl: ENSG000001820227   OMIM: 6082775   UniProtKB: Q7LFX53   

Export aliases for CHST15 gene to outside databases

Previous GC identifer: GC10M119382


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHST15 Gene:
Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular
matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of
chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II
transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of
chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as
potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript
variants encoding distinct isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for CHST15 Gene:
CHST15 (carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15) is a protein-coding gene. Diseases associated with CHST15 include morquio syndrome b, and sly syndrome. GO annotations related to this gene include 3'-phosphoadenosine 5'-phosphosulfate binding and N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity.

UniProtKB/Swiss-Prot: CHSTF_HUMAN, Q7LFX5
Function: Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6
hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E
containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal
sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure
found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated
early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific
RAG expression; however such results are unclear in vivo

Gene Wiki entry for CHST15 (GALNAC4S-6ST) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CHST15
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST15 promoter sequence
   Search Chromatin IP Primers for CHST15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHST15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26

CHST15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST15 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M125759:  view genomic region     (about GC identifiers)

Start:
125,767,182 bp from pter      End:
125,853,206 bp from pter
Size:
86,025 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHSTF_HUMAN, Q7LFX5 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 15  
Size: 561 amino acids; 64926 Da
Cofactor: Divalent metal cations (By similarity)
Cofactor: Glutathione (By similarity)
Subunit: Homodimer; disulfide-linked (Potential). The relevance of homodimerization is however unsure. May
interact with phosphorylated proteins in resting B-cells, including HCK
Sequence caution: Sequence=AAC71691.1; Type=Frameshift; Positions=180, 223, 489, 537; Sequence=AAH50540.1;
Type=Frameshift; Positions=511; Sequence=BAA25524.2; Type=Erroneous initiation;
Secondary accessions: O60338 O60474 Q86VM4
Alternative splicing: 2 isoforms:  Q7LFX5-1   Q7LFX5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHST15: NX_Q7LFX5

Explore proteomics data for CHST15 at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Glycosylation2 at Asn364
  • Modification sites at PhosphoSitePlus

  • See CHST15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001257693.1  NP_001257694.1  NP_055678.2  NP_056976.2  

    ENSEMBL proteins: 
     ENSP00000333947   ENSP00000402394   ENSP00000412477  
    Reactome Protein details: Q7LFX5

    CHST15 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals CHST15 Protein
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    Sino Biological Recombinant Protein for CHST15
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    CHST15 Antibody Products:

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    Cloud-Clone Corp. CLIAs for CHST15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q7LFX5

    ProtoNet protein and cluster: Q7LFX5

    UniProtKB/Swiss-Prot: CHSTF_HUMAN, Q7LFX5
    Similarity: Belongs to the sulfotransferase 1 family


    CHST15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHSTF_HUMAN, Q7LFX5
    Function: Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6
    hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E
    containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal
    sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure
    found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated
    early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific
    RAG expression; however such results are unclear in vivo
    Catalytic activity: 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetylgalactosamine = adenosine
    3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
    Catalytic activity: 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetylgalactosamine = adenosine
    3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
    Enzyme regulation: Inhibited by phenyl beta-GalNAc(4,6-SO(4))

         Enzyme Number (IUBMB): EC 2.8.2.331

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:00506563'-phosphoadenosine 5'-phosphosulfate binding IDA11572857
    GO:0050659N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IDA11572857
         
    CHST15 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHST15:
     Increased HPV18 LCR reporter a 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chst15):
     hematopoietic system  immune system  reproductive system 

    CHST15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Chst15tm1Oh for CHST15

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHST15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHST15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST15

    miRNA
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    miRTarBase miRNAs that target CHST15:
    hsa-mir-26b-5p (MIRT030113), hsa-mir-615-3p (MIRT040371)

    Block miRNA regulation of human, mouse, rat CHST15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST15 (see all 43):
    hsa-miR-3607-3p hsa-miR-548k hsa-miR-3653 hsa-miR-301a hsa-miR-346 hsa-miR-218 hsa-miR-9 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidCHST15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CHST15

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CHST15 (NM_015892)
    Sino Biological Human cDNA Clone for CHST15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST15

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHSTF_HUMAN, Q7LFX5: Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Note=A small
    fraction may also be present at the cell surface, where it acts as a B-cell receptor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane NAS11572857

    CHST15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHST15 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.00
    Chondroitin sulfate biosynthesis0.41
    3dermatan sulfate biosynthesis
    dermatan sulfate biosynthesis
    dermatan sulfate biosynthesis (late stages)0.00
    4Metabolism
    Metabolism0.38
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CHST15
        Articular Cartilage Extracellular Matrix


    5 BioSystems Pathways for CHST15
        B Cell Receptor Signaling Pathway
    dermatan sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis
    dermatan sulfate biosynthesis


    1 Reactome Pathway for CHST15
        Chondroitin sulfate biosynthesis


    1 Kegg Pathway  (Kegg details for CHST15):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate


    CHST15 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CHST15: 
              Hematopoiesis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CHST15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for CHST15 (Q7LFX53 ENSP000003339474) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCKP086313, ENSP000003650124I2D: score=3 STRING: ENSP00000365012
    RRAGDQ9NQL23, ENSP000003584234I2D: score=2 STRING: ENSP00000358423
    LYNP079483I2D: score=2 
    CHST11ENSP000003057254STRING: ENSP00000305725
    CHST12ENSP000002587114STRING: ENSP00000258711
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0019319hexose biosynthetic process IDA11572857
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0030206chondroitin sulfate biosynthetic process TAS--

    CHST15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHST15 (CHSTF)

    5 HMDB Compounds for CHST15    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    Chondroitin 4-sulfateChondroitin 4'-sulfate (see all 2)----
    DermatanChondroitin sulfate B (see all 13)24967-94-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    5 Novoseek inferred chemical compound relationships for CHST15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetylgalactosamine 4-sulfate 99.3 12 12874280 (1), 16024005 (1), 12423630 (1), 10871629 (1) (see all 9)
    3-phosphoadenosine 5'-phosphosulfate 88.9 6 12874280 (2), 16024005 (1), 12423630 (1), 10871629 (1) (see all 5)
    chondroitin sulfate 80.3 18 17893095 (5), 10871629 (1), 20016933 (1), 11572857 (1)
    dermatan sulfate 71.7 7 12423630 (3), 10871629 (1), 11572857 (1)
    sulfate 70 14 12874280 (3), 16024005 (3), 17893095 (2), 12423630 (1) (see all 7)



    CHST15 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHST15 gene (4 alternative transcripts): 
    NM_001270764.1  NM_001270765.1  NM_014863.3  NM_015892.4  

    Unigene Cluster for CHST15:

    Carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
    Hs.287537  [show with all ESTs]
    Unigene Representative Sequence: CR749804
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346248(uc001lhm.3 uc001lhn.3) ENST00000476765 ENST00000462406
    ENST00000435907 ENST00000421115(uc010que.2 uc001lho.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CHST15 (see all 43):
    hsa-miR-3607-3p hsa-miR-548k hsa-miR-3653 hsa-miR-301a hsa-miR-346 hsa-miR-218 hsa-miR-9 hsa-miR-23a
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST15
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      QuantiTect SYBR Green Assays in human, mouse, rat CHST15
      QuantiFast Probe-based Assays in human, mouse, rat CHST15

    Additional mRNA sequence: 

    AB011170.1 AB062423.1 AF026477.1 AK294961.1 BC027908.1 BC050540.1 BC075813.1 CR749804.1 

    7 DOTS entries:

    DT.100760342  DT.116693  DT.100766912  DT.302980  DT.95305104  DT.95305106  DT.95232834 

    Selected AceView cDNA sequences (see all 171):

    AB011170 BI753246 AI372888 CA427266 AU124257 BU527106 CA488972 AA227793 
    BG236301 CB156744 CR749804 BQ894229 Z43757 BQ066068 AA227859 BM977716 
    BC027908 BF174234 AW503727 AA326265 BX095424 Z39817 F09261 AB062423 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHST15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATTGAAGT
    CHST15 Expression
    About this image


    CHST15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Lens
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
    CHST15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHST15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.287537

    UniProtKB/Swiss-Prot: CHSTF_HUMAN, Q7LFX5
    Tissue specificity: Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and
    adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B,
    pre-B, and mature B-cell lines, it colocalizes with RAG1

        Pathway & Disease-focused RT2 Profiler PCR Array including CHST15: 
              Hematopoiesis in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CHST15 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst151 , 5 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) more1, 5 86.39(n)1
    92.51(a)1
      7 (76.29 cM)5
    775901  NM_029935.51  NP_084211.21 
     1322357805 
    chicken
    (Gallus gallus)
    Aves CHST151 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) more 73.64(n)
    78.53(a)
      423952  XM_421811.4  XP_421811.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHST156
    carbohydrate (N-acetylgalactosamine 4-sulfate 6-O)...
    75(a)
    1 ↔ 1
    3(61065430-61090073)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5655231 carbohydrate sulfotransferase 15-like 60.65(n)
    57.84(a)
      565523  XM_688803.5  XP_693895.2 


    ENSEMBL Gene Tree for CHST15 (if available)
    TreeFam Gene Tree for CHST15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHST15 (see all 1920)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs717049051,2
    C--125767500(+) CTCTGGA/-GAGAA 2 -- ut311Minor allele frequency- -:0.50CSA 2
    rs599932731,2
    C--125774914(+) AGGGC-/GGGGGG 2 -- int10--------
    rs345918171,2
    C--125777025(+) CACAA-/TGTGGTA 2 -- int10--------
    rs57886451,2
    C--125780753(-) CCCCC-/CGTACC 6 V R fra1 int1 trp31Minor allele frequency- C:0.00NA 2
    rs2009363451,2
    C--125782327(+) CATTTC/TTTTTT 4 -- int10--------
    rs1441906061,2
    C--125783001(+) AAAAA-/AAAAAA 4 -- int10--------
    rs599401521,2
    C--125783015(+) AAAAA-/A/AA  
            
    GAGGT
    4 -- int11NA 2
    rs574698331,2
    C--125792439(+) AATTA-/ATAGAAGTA
    A
    /TAGAAGTAAA
    GGCTG
    4 -- int10--------
    rs1114121821,2
    C,F--125794273(+) CTAACG/AGGGAC 4 -- int11Minor allele frequency- A:0.50WA 2
    rs1134424781,2
    C,F--125794642(+) CTAACG/AGGGAC 4 -- int12Minor allele frequency- A:0.50NA WA 4

    HapMap Linkage Disequilibrium report for CHST15 (125767182 - 125853206 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CHST15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2742617CNV Deletion23290073
    esv33043CNV Loss17666407
    nsv524333CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHST15
    DNA2.0 Custom Variant and Variant Library Synthesis for CHST15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608277    OMIM disorders: --

    8 diseases for CHST15:    
    About MalaCards
    morquio syndrome b    sly syndrome    mucopolysaccharidoses    tonsillitis
    labyrinthitis    alzheimer's disease    colorectal cancer    cerebritis


    CHST15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHST15
    Human Genome Epidemiology (HuGE) Navigator: CHST15 (0 documents)

    Export disorders for CHST15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHST15 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CHST15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene. (PubMed id 11572857)1, 2, 3, 9 Ohtake S.... Habuchi O. (J. Biol. Chem. 2001)
    2. hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1). (PubMed id 9754571)1, 2, 3 Verkoczy L.K.... Berinstein N.L. (Eur. J. Immunol. 1998)
    3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    4. A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase. (PubMed id 12874280)1, 2, 9 Ohtake S.... Habuchi O. (J. Biol. Chem. 2003)
    5. Synthesis of sulfated phenyl 2-acetamido-2-deoxy-D--D- galactopyranosides. 4-O-Sulfated phenyl 2-acetamido-2-deoxy-beta-D- galactopyranoside is a competitive acceptor that decreases sulfation of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-O- sulfotransferase. (PubMed id 16024005)1, 2, 9 Sawada T.... Habuchi O. (Carbohydr. Res. 2005)
    6. Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells. (PubMed id 10749872)1, 2, 9 Verkoczy L.K.... Berinstein N.L. (J. Biol. Chem. 2000)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    9. Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer. (PubMed id 11032940)1, 2 Yuki M....Horii A. (Oncol. Rep. 2000)
    10. Role of GalNAc4S-6ST in astrocytic tumor progression. (PubMed id 23349846)1 Kobayashi T....Nakayama J. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51363 HGNC: 18137 AceView: GALNAC4S-6ST Ensembl:ENSG00000182022 euGenes: HUgn51363
    ECgene: CHST15 Kegg: 51363 H-InvDB: CHST15

    (According to HUGE)
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    HUGE: KIAA0598

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHST15 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=CHST15

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHST15 gene:
    Search GeneIP for patents involving CHST15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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