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Aliases for CHST13 Gene

Aliases for CHST13 Gene

  • Carbohydrate (Chondroitin 4) Sulfotransferase 13 2 3
  • C4ST3 3 4 6
  • Chondroitin 4-O-Sulfotransferase 3 3 4
  • Chondroitin 4-Sulfotransferase 3 3 4
  • C4ST-3 3 4
  • Carbohydrate Sulfotransferase 13 3
  • EC 2.8.2.5 4

External Ids for CHST13 Gene

Previous GeneCards Identifiers for CHST13 Gene

  • GC03P127525
  • GC03P127564
  • GC03P127725
  • GC03P126243
  • GC03P123622

Summaries for CHST13 Gene

Entrez Gene Summary for CHST13 Gene

  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST13 Gene

CHST13 (Carbohydrate (Chondroitin 4) Sulfotransferase 13) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include N-acetylgalactosamine 4-O-sulfotransferase activity and chondroitin 4-sulfotransferase activity. An important paralog of this gene is CHST11.

UniProtKB/Swiss-Prot for CHST13 Gene

  • Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST13 Gene

Genomics for CHST13 Gene

Regulatory Elements for CHST13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHST13 Gene

Start:
126,524,283 bp from pter
End:
126,543,291 bp from pter
Size:
19,009 bases
Orientation:
Plus strand

Genomic View for CHST13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHST13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST13 Gene

Proteins for CHST13 Gene

  • Protein details for CHST13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NET6-CHSTD_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 13
    Protein Accession:
    Q8NET6
    Secondary Accessions:
    • Q3SYA3
    • Q3SYA5

    Protein attributes for CHST13 Gene

    Size:
    341 amino acids
    Molecular mass:
    38920 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CHST13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHST13 Gene

Proteomics data for CHST13 Gene at MOPED

Post-translational modifications for CHST13 Gene

  • Glycosylation at Asn331
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHST13 Gene

Domains for CHST13 Gene

Gene Families for CHST13 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for CHST13 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NET6

UniProtKB/Swiss-Prot:

CHSTD_HUMAN :
  • Q8NET6
Family:
  • Belongs to the sulfotransferase 2 family.
genes like me logo Genes that share domains with CHST13: view

Function for CHST13 Gene

Molecular function for CHST13 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + chondroitin = adenosine 3,5-bisphosphate + chondroitin 4-sulfate.
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan

Enzyme Numbers (IUBMB) for CHST13 Gene

Gene Ontology (GO) - Molecular Function for CHST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity IDA 12080076
GO:0008146 sulfotransferase activity --
GO:0047756 chondroitin 4-sulfotransferase activity IDA 12080076
genes like me logo Genes that share ontologies with CHST13: view

Phenotypes for CHST13 Gene

GenomeRNAi human phenotypes for CHST13:
genes like me logo Genes that share phenotypes with CHST13: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHST13

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHST13 Gene

Localization for CHST13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST13 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST13 Gene COMPARTMENTS Subcellular localization image for CHST13 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane NAS 12080076
genes like me logo Genes that share ontologies with CHST13: view

Pathways for CHST13 Gene

genes like me logo Genes that share pathways with CHST13: view

Interacting Proteins for CHST13 Gene

Gene Ontology (GO) - Biological Process for CHST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0016051 carbohydrate biosynthetic process IEA --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHST13: view

Compounds for CHST13 Gene

(4) HMDB Compounds for CHST13 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Chondroitin
  • Chondroitin-D-glucuronate
9007-27-6
Chondroitin 4-sulfate
  • Chondroitin 4'-sulfate
Not Available
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7
genes like me logo Genes that share compounds with CHST13: view

Transcripts for CHST13 Gene

mRNA/cDNA for CHST13 Gene

Unigene Clusters for CHST13 Gene

Carbohydrate (chondroitin 4) sulfotransferase 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHST13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST13 Gene

No ASD Table

Relevant External Links for CHST13 Gene

GeneLoc Exon Structure for
CHST13
ECgene alternative splicing isoforms for
CHST13

Expression for CHST13 Gene

mRNA expression in normal human tissues for CHST13 Gene

mRNA differential expression in normal tissues according to GTEx for CHST13 Gene

This gene is overexpressed in Liver (24.4), Testis (10.2), and Whole Blood (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHST13 Gene

SOURCE GeneReport for Unigene cluster for CHST13 Gene Hs.292375

mRNA Expression by UniProt/SwissProt for CHST13 Gene

Q8NET6-CHSTD_HUMAN
Tissue specificity: Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney.
genes like me logo Genes that share expressions with CHST13: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CHST13 Gene

Orthologs for CHST13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST13 35
  • 96.96 (n)
  • 97.65 (a)
CHST13 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHST13 35
  • 86.92 (n)
  • 82.01 (a)
CHST13 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHST13 35
  • 87.77 (n)
  • 82.84 (a)
mouse
(Mus musculus)
Mammalia Chst13 35
  • 80.34 (n)
  • 79.94 (a)
Chst13 16
Chst13 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHST13 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHST13 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chst13 35
  • 80.37 (n)
  • 79.88 (a)
chicken
(Gallus gallus)
Aves CHST13 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST13 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CHST13 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31743 36
  • 36 (a)
OneToMany
Species with no ortholog for CHST13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST13 Gene

ENSEMBL:
Gene Tree for CHST13 (if available)
TreeFam:
Gene Tree for CHST13 (if available)

Paralogs for CHST13 Gene

Paralogs for CHST13 Gene

Selected SIMAP similar genes for CHST13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHST13: view

Variants for CHST13 Gene

Sequence variations from dbSNP and Humsavar for CHST13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1388096 -- 126,524,121(-) GCCCG(C/G)TCCTC upstream-variant-2KB
rs1388097 -- 126,524,031(-) TCGCC(C/T)CTGGG upstream-variant-2KB
rs1994643 -- 126,523,826(-) CCGCC(C/G)TCAGT upstream-variant-2KB
rs6786437 -- 126,522,952(+) CATTT(C/T)CTGTA upstream-variant-2KB
rs6796854 -- 126,525,748(+) GTCCC(A/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST13 Gene

Variant ID Type Subtype PubMed ID
nsv877432 CNV Loss 21882294
nsv829717 CNV Loss 17160897
dgv5246n71 CNV Loss 21882294
dgv5247n71 CNV Loss 21882294
nsv877444 CNV Loss 21882294
esv2725870 CNV Deletion 23290073
esv2667811 CNV Deletion 23128226
esv2725871 CNV Deletion 23290073
esv2435482 CNV Insertion 19546169
nsv822240 CNV Gain 20364138
nsv822241 CNV Gain 20364138

Relevant External Links for CHST13 Gene

HapMap Linkage Disequilibrium report
CHST13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST13 Gene

Disorders for CHST13 Gene

Relevant External Links for CHST13

Genetic Association Database (GAD)
CHST13
Human Genome Epidemiology (HuGE) Navigator
CHST13
genes like me logo Genes that share disorders with CHST13: view

No data available for UniProtKB/Swiss-Prot for CHST13 Gene

Publications for CHST13 Gene

  1. Molecular cloning and characterization of chondroitin-4-O- sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases. (PMID: 12080076) Kang H.-G. … Schachner M. (J. Biol. Chem. 2002) 2 3 4 23
  2. Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria. (PMID: 20580388) Valente B. … Silveira H. (Trans. R. Soc. Trop. Med. Hyg. 2010) 3 48
  3. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A. … Oetting W.S. (Transplantation 2010) 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4

Products for CHST13 Gene

Sources for CHST13 Gene

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