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Aliases for CHST13 Gene

Aliases for CHST13 Gene

  • Carbohydrate Sulfotransferase 13 2 3 5
  • Chondroitin 4-Sulfotransferase 3 2 3 4
  • Carbohydrate (Chondroitin 4) Sulfotransferase 13 2 3
  • Chondroitin 4-O-Sulfotransferase 3 3 4
  • C4ST-3 3 4
  • C4ST3 3 4
  • EC 2.8.2.5 4

External Ids for CHST13 Gene

Previous GeneCards Identifiers for CHST13 Gene

  • GC03P127525
  • GC03P127564
  • GC03P127725
  • GC03P126243
  • GC03P123622

Summaries for CHST13 Gene

Entrez Gene Summary for CHST13 Gene

  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST13 Gene

CHST13 (Carbohydrate Sulfotransferase 13) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. GO annotations related to this gene include sulfotransferase activity and chondroitin 4-sulfotransferase activity. An important paralog of this gene is CHST11.

UniProtKB/Swiss-Prot for CHST13 Gene

  • Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST13 Gene

Genomics for CHST13 Gene

Regulatory Elements for CHST13 Gene

Enhancers for CHST13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F126522 1.6 FANTOM5 Ensembl ENCODE 59.6 +2.8 2834 8.6 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 GLIS2 ZNF143 PAF1 ZNF263 CHST13 TXNRD3NB TXNRD3 NUP210P1 OR7E29P C3orf22 ZXDC UROC1
GH03F126539 1.5 FANTOM5 Ensembl ENCODE 32.7 +17.0 17048 3.9 PKNOX1 SIN3A ARID4B DMAP1 ZNF48 YY1 ZNF766 FOS ZNF263 REST CHST13 ZXDC C3orf22
GH03F126549 0.6 Ensembl 62.8 +25.4 25418 1.0 HLF ZMYM3 KDM1A RAD21 THRB CHST13 TXNRD3NB TXNRD3 NUP210P1 C3orf22
GH03F126745 1.1 Ensembl ENCODE 10.9 +222.2 222218 1.4 ELF3 SOX13 CTCF SAP130 ZNF792 ARID4B CEBPG ZIC2 RAD21 ZNF48 CHCHD6 CHST13 GC03P126746 GC03P126709
GH03F126683 0.7 Ensembl ENCODE 11.7 +160.5 160509 2.0 SMARCA4 POLR2A ZNF384 TXNRD3 CHST13 NUP210P1 FAM86JP LOC645852 CHCHD6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHST13 on UCSC Golden Path with GeneCards custom track

Promoters for CHST13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001372941 217 1001 ELF3 TBP MLX ARID4B DMAP1 ZNF48 ZSCAN9 DNMT3B RARA YY1

Genomic Location for CHST13 Gene

Chromosome:
3
Start:
126,524,283 bp from pter
End:
126,543,291 bp from pter
Size:
19,009 bases
Orientation:
Plus strand

Genomic View for CHST13 Gene

Genes around CHST13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHST13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHST13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST13 Gene

Proteins for CHST13 Gene

  • Protein details for CHST13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NET6-CHSTD_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 13
    Protein Accession:
    Q8NET6
    Secondary Accessions:
    • Q3SYA3
    • Q3SYA5

    Protein attributes for CHST13 Gene

    Size:
    341 amino acids
    Molecular mass:
    38920 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CHST13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHST13 Gene

Post-translational modifications for CHST13 Gene

  • Glycosylation at Asn 331
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHST13 Gene

Domains & Families for CHST13 Gene

Gene Families for CHST13 Gene

Protein Domains for CHST13 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NET6

UniProtKB/Swiss-Prot:

CHSTD_HUMAN :
  • Belongs to the sulfotransferase 2 family.
Family:
  • Belongs to the sulfotransferase 2 family.
genes like me logo Genes that share domains with CHST13: view

Function for CHST13 Gene

Molecular function for CHST13 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + chondroitin = adenosine 3,5-bisphosphate + chondroitin 4-sulfate.
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.

Enzyme Numbers (IUBMB) for CHST13 Gene

Gene Ontology (GO) - Molecular Function for CHST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity IDA 12080076
GO:0008146 sulfotransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0047756 chondroitin 4-sulfotransferase activity TAS --
genes like me logo Genes that share ontologies with CHST13: view
genes like me logo Genes that share phenotypes with CHST13: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHST13 Gene

Localization for CHST13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST13 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHST13 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 12080076
genes like me logo Genes that share ontologies with CHST13: view

Pathways & Interactions for CHST13 Gene

genes like me logo Genes that share pathways with CHST13: view

Interacting Proteins for CHST13 Gene

Gene Ontology (GO) - Biological Process for CHST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0016051 carbohydrate biosynthetic process IEA --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHST13: view

No data available for SIGNOR curated interactions for CHST13 Gene

Drugs & Compounds for CHST13 Gene

(1) Drugs for CHST13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chondroitin Nutra 43

(3) Additional Compounds for CHST13 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Chondroitin 4-sulfate
  • Chondroitin 4'-sulfate
  • Chondroitin 4'-sulphate
  • Chondroitin sulfate A
  • Chondroitin sulphate A
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with CHST13: view

Transcripts for CHST13 Gene

mRNA/cDNA for CHST13 Gene

Unigene Clusters for CHST13 Gene

Carbohydrate (chondroitin 4) sulfotransferase 13:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST13 Gene

No ASD Table

Relevant External Links for CHST13 Gene

GeneLoc Exon Structure for
CHST13
ECgene alternative splicing isoforms for
CHST13

Expression for CHST13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHST13 Gene

mRNA differential expression in normal tissues according to GTEx for CHST13 Gene

This gene is overexpressed in Liver (x24.4), Testis (x10.2), and Whole Blood (x8.7).

Protein differential expression in normal tissues from HIPED for CHST13 Gene

This gene is overexpressed in Platelet (46.8), Fetal Liver (12.4), and Testis (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHST13 Gene



Protein tissue co-expression partners for CHST13 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHST13 Gene:

CHST13

SOURCE GeneReport for Unigene cluster for CHST13 Gene:

Hs.292375

mRNA Expression by UniProt/SwissProt for CHST13 Gene:

Q8NET6-CHSTD_HUMAN
Tissue specificity: Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney.
genes like me logo Genes that share expression patterns with CHST13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CHST13 Gene

Orthologs for CHST13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST13 34 35
  • 96.96 (n)
dog
(Canis familiaris)
Mammalia CHST13 34
  • 87.77 (n)
cow
(Bos Taurus)
Mammalia CHST13 34 35
  • 86.92 (n)
rat
(Rattus norvegicus)
Mammalia Chst13 34
  • 80.37 (n)
mouse
(Mus musculus)
Mammalia Chst13 34 16 35
  • 80.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHST13 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHST13 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHST13 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST13 35
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CHST13 35
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31743 35
  • 36 (a)
OneToMany
Species where no ortholog for CHST13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST13 Gene

ENSEMBL:
Gene Tree for CHST13 (if available)
TreeFam:
Gene Tree for CHST13 (if available)

Paralogs for CHST13 Gene

Paralogs for CHST13 Gene

(6) SIMAP similar genes for CHST13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHST13: view

Variants for CHST13 Gene

Sequence variations from dbSNP and Humsavar for CHST13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1054097 -- 126,543,249(+) AGCTG(C/G)GCGGT intron-variant, utr-variant-3-prime
rs1056522 -- 126,542,502(-) GGCGC(C/T)GCTGG intron-variant, reference, missense
rs1056523 -- 126,542,364(-) CCTCC(A/G)CCAGC intron-variant, reference, missense
rs1056524 -- 126,542,359(-) GCCAG(C/T)GTCTC intron-variant, reference, synonymous-codon
rs10580329 -- 126,543,739(+) GTGAG(-/AG)GAATT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CHST13 Gene

Variant ID Type Subtype PubMed ID
nsv955338 CNV deletion 24416366
nsv829717 CNV loss 17160897
nsv822241 CNV gain 20364138
nsv822240 CNV gain 20364138
nsv1153775 CNV deletion 26484159
nsv1151449 CNV insertion 26484159
nsv1149564 CNV deletion 26484159
nsv1145446 CNV deletion 24896259
nsv1137754 CNV deletion 24896259
esv3426789 CNV duplication 20981092
esv2725871 CNV deletion 23290073
esv2725870 CNV deletion 23290073
esv2667811 CNV deletion 23128226
esv2435482 CNV insertion 19546169
dgv2591n106 CNV tandem duplication 24896259

Variation tolerance for CHST13 Gene

Gene Damage Index Score: 10.89; 91.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHST13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHST13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST13 Gene

Disorders for CHST13 Gene

Relevant External Links for CHST13

Genetic Association Database (GAD)
CHST13
Human Genome Epidemiology (HuGE) Navigator
CHST13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHST13

No disorders were found for CHST13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHST13 Gene

Publications for CHST13 Gene

  1. Molecular cloning and characterization of chondroitin-4-O- sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases. (PMID: 12080076) Kang H.-G. … Schachner M. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria. (PMID: 20580388) Valente B. … Silveira H. (Trans. R. Soc. Trop. Med. Hyg. 2010) 3 46 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A. … Oetting W.S. (Transplantation 2010) 46 64
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 64

Products for CHST13 Gene

Sources for CHST13 Gene

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