Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHST12 Gene

protein-coding   GIFtS: 52
GCID: GC07P002448

carbohydrate (chondroitin 4) sulfotransferase 12

 Explore 2 diseases affiliated with
CHST12 via our new
 Human Malady Compendium 
Biological research products
for CHST12
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Carbohydrate (Chondroitin 4) Sulfotransferase 121 2     Sulfotransferase Hlo2 3
C4ST21 2 3     C4ST-22 3
C4S-21 2     Carbohydrate Sulfotransferase 122
Chondroitin 4-O-Sulfotransferase 22 3     EC 2.8.2.53
Chondroitin 4-Sulfotransferase 22 3     

External Ids:    HGNC: 174231   Entrez Gene: 555012   Ensembl: ENSG000001362137   OMIM: 6101295   UniProtKB: Q9NRB33   

Export aliases for CHST12 gene to outside databases

Previous GC identifers: GC07P002153 GC07P002188 GC07P002189 GC07P002216 GC07P002409 GC07P002274 GC07P002446 GC07P002364 GC07P002447


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHST12:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and
catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and
desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is
distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants
differing only in their 5' UTRs have been found for this gene. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: CHSTC_HUMAN, Q9NRB3
Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin
and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and
is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan
sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor

Gene Wiki entry for CHST12


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHST12 gene promoter:
         Tal-1beta   RORalpha2   Roaz   E47   YY1   c-Ets-1   Max   IRF-7A   ZID   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHST12 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHST12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

CHST12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST12 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P002448:  view genomic region     (about GC identifiers)

Start:
2,443,223 bp from pter      End:
2,474,242 bp from pter
Size:
31,020 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 2,491,153-2,522,134     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHSTC_HUMAN, Q9NRB3 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 12  
Size: 414 amino acids; 48414 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: A4D1Z9 Q502W3 Q9NXY7

Explore the universe of human proteins at neXtProt for CHST12: NX_Q9NRB3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRB3

  • CHST12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230723.1  NP_001230724.1  NP_061111.1  

    ENSEMBL proteins: 
     ENSP00000258711   ENSP00000411207  
    Reactome Protein details: Q9NRB3
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CHST12
    OriGene Protein Over-expression Lysate: CHST12
    OriGene Custom Protein Services for CHST12 
    GenScript Custom Purified and Recombinant Proteins Services for CHST12
    Novus Biologicals CHST12 Proteins
    Novus Biologicals CHST12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CHST12

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane ----
    GO:0030173integral to Golgi membrane NAS10781601


    CHST12 for ontologies           About GeneDecksing



    CHST12 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CHST12 
    GenScript Custom Superior Antibodies Services for CHST12
    Novus Biologicals CHST12 Antibodies
    Search for Antibodies for CHST12 at Abcam  
    Uscn Antibodies for CHST12
    Search ThermoFisher Antibodies for CHST12

    Assay Products for CHST12: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHST12
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CHST12


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CHST12 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR005331 Sulfotransferase
     IPR018011 Carb_sulfotransferase-rel

    Graphical View of Domain Structure for InterPro Entry Q9NRB3

    ProtoNet protein and cluster: Q9NRB3

    UniProtKB/Swiss-Prot: CHSTC_HUMAN, Q9NRB3
    Similarity: Belongs to the sulfotransferase 2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CHSTC_HUMAN, Q9NRB3
    Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin
    and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and
    is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan
    sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor
    Catalytic activity: 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate

    Enzyme Number (IUBMB): EC 2.8.2.51

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: CHST12
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST12
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST12 (see all 9):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-34a hsa-miR-338-5p hsa-miR-656 hsa-miR-508-5p hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHST12 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHST12 (see all 7)
    OriGene shRNA RFP: CHST12
    OriGene siRNA: CHST12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHST12

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHST12 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHST12
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CHST12 (NM_018641)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST12 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHST12
    Search LifeMap BioReagents cell lines for CHST12

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST12

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0047756chondroitin 4-sulfotransferase activity IDA10781601
    GO:00506563'-phosphoadenosine 5'-phosphosulfate binding NAS10781601


    CHST12 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CHST12:
     Decreased Hepatitis C virus re 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    MPS IIIC - Sanfilippo syndrome C1.00
    MPS IIIA - Sanfilippo syndrome A1.00
    MPS I - Hurler syndrome1.00
    MPS IIID - Sanfilippo syndrome D1.00
    Mucopolysaccharidoses1.00
    MPS IX - Natowicz syndrome1.00
    MPS IV - Morquio syndrome A1.00
    MPS II - Hunter syndrome1.00
    2dermatan sulfate biosynthesis
    Glycosaminoglycan biosynthesis - chondroitin sulfate0.73
    chondroitin sulfate biosynthesis (late stages)0.32
    chondroitin sulfate biosynthesis0.64
    Chondroitin sulfate biosynthesis0.24
    3Disease
    Disease1.00
    4Metabolism
    Metabolism1.00
    5A tetrasaccharide linker sequence is required for GAG synthesis
    Chondroitin sulfate/dermatan sulfate metabolism0.54

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for CHST12 
        chondroitin sulfate biosynthesis (late stages)
    metapathway biotransformation
    chondroitin sulfate biosynthesis

    5/18        Reactome Pathways for CHST12 (see all 18)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS II - Hunter syndrome


    2         Kegg Pathways  (Kegg details for CHST12):
        Glycosaminoglycan biosynthesis - chondroitin sulfate
    Sulfur metabolism


    CHST12 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHST12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for CHST12 (Q9NRB31, 3 ENSP000002587114) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UGGT1Q9NYU21, 3, ENSP000002592534EBI-1042837,EBI-1056389 I2D: score=2 STRING: ENSP00000259253
    BGNENSP000003273364STRING: ENSP00000327336
    CHPFENSP000002437764STRING: ENSP00000243776
    CHST15ENSP000003339474STRING: ENSP00000333947
    CHST3ENSP000003622074STRING: ENSP00000362207
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0016051carbohydrate biosynthetic process IEA--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0030206chondroitin sulfate biosynthetic process TAS--


    CHST12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHST12 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHST12

    5 HMDB Compounds for CHST12    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    Chondroitin 4-sulfateChondroitin 4'-sulfate (see all 2)----
    DermatanChondroitin sulfate B (see all 13)24967-94-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--
    1 Novoseek chemical compound relationship for CHST12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 85.6 6 16118286 (1), 10988300 (1)

    Search CenterWatch for drugs/clinical trials and news about CHST12 / CHSTC 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHST12 gene (3 alternative transcripts): 
    NM_001243794.1  NM_001243795.1  NM_018641.4  

    Unigene Cluster for CHST12:

    Carbohydrate (chondroitin 4) sulfotransferase 12
    Hs.213088  [show with all ESTs]
    Unigene Representative Sequence: NM_018641
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258711(uc003smc.3 uc003smd.3 uc021zyu.1) ENST00000432336


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: CHST12
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST12
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST12 (see all 9):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-34a hsa-miR-338-5p hsa-miR-656 hsa-miR-508-5p hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHST12 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHST12 (see all 7)
    OriGene shRNA RFP: CHST12
    OriGene siRNA: CHST12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST12
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHST12 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHST12
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CHST12 (NM_018641)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST12 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHST12
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHST12
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST12

    Additional cDNA sequence: 

    AF239822.1 AJ289131.1 AK223191.1 AK223211.1 AK313484.1 AY358574.1 BC002918.1 BC015954.1 
    BC095492.1 

    5 DOTS entries:

    DT.411485  DT.100836713  DT.92447164  DT.100742748  DT.97841141 

    24/99 AceView cDNA sequences (see all 99):

    AA449104 BI828898 AA252298 BQ213557 BP340554 AW292663 AJ289131 AA252149 
    BM677270 BM721669 BE276749 BE407252 BP339538 BU538747 CR615984 AI343334 
    AI872887 CB992553 AI648561 AA449539 BU539269 AA583629 BX095157 BQ709597 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHST12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGCGGCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CHST12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHST12

    SOURCE GeneReport for Unigene cluster: Hs.213088

    UniProtKB/Swiss-Prot: CHSTC_HUMAN, Q9NRB3
    Tissue specificity: Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland,
    adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung

        SABiosciences Custom PCR Arrays for CHST12
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHST12
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHST12
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST12
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHST12 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CHST121 carbohydrate (chondroitin 4) sulfotransferase 12 76.94(n)
    78.4(a)
      416469  XM_414775.3  XP_414775.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHST126
    --
    74(a)
    1 ↔ 1
    GL343340.1(68356-69612)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.39902 Xenopus laevis transcribed sequence with weak similarity more 73.22(n)    48046065 
    zebrafish
    (Danio rerio)
    Actinopterygii chst12a1 carbohydrate (chondroitin 4) sulfotransferase 12a 63.66(n)
    61.95(a)
      407076  NM_213547.1  NP_998712.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG317436
    --
    29(a)
    1 → many
    2L(16879517-16886323)


    ENSEMBL Gene Tree for CHST12 (if available)
    TreeFam Gene Tree for CHST12 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHST12 gene
    CHST132  CHST92  CHST112  CHST102  CHST82  CHST142  
    4 SIMAP similar genes for CHST12 using alignment to 2 protein entries:     CHSTC_HUMAN (see all proteins):
    CHST11    CHST9    CHST13    CHST8

    CHST12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/659 NCBI SNPs in CHST12 are shown (see all 659    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1489376441,2
    --2441294(+) ACTTCA/GGCCTC 3 -- us2k10--------
    rs1915397871,2
    --2441325(+) GTGTGA/CGCCAC 3 -- us2k10--------
    rs559707421,2
    C,F,--2441337(+) GCACAT/CGGCTG 3 -- us2k110Minor allele frequency- C:0.34WA NA CSA EA 372
    rs1436637811,2
    --2441382(+) CAGGGC/TGACAT 3 -- us2k10--------
    rs1837462321,2
    --2441415(+) TACATA/GCGTGC 3 -- us2k10--------
    rs1888593341,2
    --2441434(+) ATATGA/TATGTA 3 -- us2k10--------
    rs765791991,2
    F,--2441465(+) CATGCA/GTAATA 3 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1812848361,2
    --2441471(+) TAATAA/CAGGTC 3 -- us2k10--------
    rs1145807731,2
    F,--2441541(+) TATGCA/CTTACA 3 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1481593141,2
    --2441612(+) GTGGTG/TGTTTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHST12 (2443223 - 2474242 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CHST12: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHST12
    DNA2.0 Custom Variant and Variant Library Synthesis for CHST12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CHST12 for disorders           About GeneDecksing

    OMIM gene information: 610129    OMIM disorders: --

    2 diseases for CHST12:    About MalaCards
    thyroiditis    malaria

    Human Genome Epidemiology (HuGE) Navigator: CHST12 (1 document)

    Export disorders for CHST12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHST12 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with CHST12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of two distinct human chondroitin 4- O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. (PubMed id 10781601)1, 2, 3 Hiraoka N.... Fukuda M. (2000)
    2. Specificities of three distinct human chondroitin/dermatan N- acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor. Implication of differential roles in dermatan sulfate biosynthesis. (PubMed id 12847091)1, 2, 9 Mikami T.... Sugahara K. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (2011)
    8. Natural frequency of polymorphisms linked to the chon droitin 4-sulfotransferase genes and its association with placental malaria. (PubMed id 20580388)1 Valente B....Silveira H. (2010)
    9. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55501 HGNC: 17423 AceView: CHST12 Ensembl:ENSG00000136213 euGenes: HUgn55501
    ECgene: CHST12 Kegg: 55501 H-InvDB: CHST12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHST12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHST12 gene:
    Search GeneIP for patents involving CHST12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CHST12  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHST12   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHST12  
     OriGene Protein Over-expression Lysate for CHST12   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CHST12   OriGene 3'-UTR Clone for CHST12  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHST12   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHST12  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CHST12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHST12   OriGene Custom Protein Services for CHST12  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHST12
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHST12
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST12
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST12
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST12
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST12
     GenScript Custom Purified and Recombinant Proteins Services for CHST12 GenScript cDNA clones with any tag delivered in your preferred vector for CHST12
     GenScript Custom Assay Services for CHST12 GenScript Custom Superior Antibodies Services for CHST12
     GenScript Custom overexpressing Cell Line Services for CHST12 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CHST12 promoter
     Search Chromatin IP Primers for CHST12
     RT2 qPCR Primer Assay in human, mouse, rat CHST12
     Search GNC Networks for CHST12
     SABiosciences Custom PCR Arrays for CHST12
     Search Tocris compounds for CHST12
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CHST12 antibodies
     CHST12 proteins
     CHST12 lysates
     Search for Antibodies for CHST12 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CHST12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CHST12 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CHST12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST12
     SwitchGear 3'UTR luciferase reporter plasmids for CHST12
     SwitchGear Promoter luciferase reporter plasmids for CHST12
     Search ThermoFisher Antibodies for CHST12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST12
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHST12 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4