Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHST12 Gene

Aliases for CHST12 Gene

  • Carbohydrate Sulfotransferase 12 2 3 5
  • Chondroitin 4-Sulfotransferase 2 2 3 4
  • Carbohydrate (Chondroitin 4) Sulfotransferase 12 2 3
  • Chondroitin 4-O-Sulfotransferase 2 3 4
  • Sulfotransferase Hlo 3 4
  • C4ST-2 3 4
  • C4ST2 3 4
  • EC 2.8.2.5 4
  • C4S-2 3

External Ids for CHST12 Gene

Previous GeneCards Identifiers for CHST12 Gene

  • GC07P002153
  • GC07P002188
  • GC07P002189
  • GC07P002216
  • GC07P002409
  • GC07P002274
  • GC07P002446
  • GC07P002364
  • GC07P002447
  • GC07P002448

Summaries for CHST12 Gene

Entrez Gene Summary for CHST12 Gene

  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST12 Gene

CHST12 (Carbohydrate Sulfotransferase 12) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. GO annotations related to this gene include sulfotransferase activity and chondroitin 4-sulfotransferase activity. An important paralog of this gene is CHST11.

UniProtKB/Swiss-Prot for CHST12 Gene

  • Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

Gene Wiki entry for CHST12 Gene

Additional gene information for CHST12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST12 Gene

Genomics for CHST12 Gene

Regulatory Elements for CHST12 Gene

Enhancers for CHST12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H002756 2 FANTOM5 Ensembl ENCODE dbSUPER 30 +357.1 357068 8 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 ZNF766 CBX5 ZNF143 CHST12 GNA12 BRAT1 AMZ1 LFNG EIF3B TTYH3 SNX8 GC07M002729 PIR32151
GH07H002626 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +231.1 231099 16 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 TTYH3 LFNG AMZ1 CHST12 BRAT1 EIF3B IQCE SNX8
GH07H002606 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12 +205.0 205027 3 CTCF ARID4B PLRG1 REST ZIC2 RAD21 NR2F2 CTBP1 CEBPA ZNF701 TTYH3 BRAT1 AMZ1 CHST12 IQCE LFNG SNX8 GC07P002574
GH07H001456 1.7 FANTOM5 ENCODE dbSUPER 10.5 -943.1 -943070 7 HDGF ARNT ARID4B SIN3A DMAP1 ZNF766 CBX5 ZNF207 FOS SP3 INTS1 DNAAF5 SUN1 EIF3B MRM2 CHST12 MAFK ENSG00000225981 ENSG00000273230
GH07H002309 1.4 FANTOM5 ENCODE 10.6 -91.2 -91248 5 HDGF PKNOX1 MLX ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 ZBTB7B SNX8 NUDT1 MRM2 MAD1L1 CHST12 BRAT1 GC07P002305 GC07M002345
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHST12 on UCSC Golden Path with GeneCards custom track

Promoters for CHST12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000207766 274 1601 HDGF ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 BRCA1 TCF12 ZNF121

Genomic Location for CHST12 Gene

Chromosome:
7
Start:
2,403,526 bp from pter
End:
2,448,483 bp from pter
Size:
44,958 bases
Orientation:
Plus strand

Genomic View for CHST12 Gene

Genes around CHST12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHST12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHST12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST12 Gene

Proteins for CHST12 Gene

  • Protein details for CHST12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRB3-CHSTC_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 12
    Protein Accession:
    Q9NRB3
    Secondary Accessions:
    • A4D1Z9
    • Q502W3
    • Q9NXY7

    Protein attributes for CHST12 Gene

    Size:
    414 amino acids
    Molecular mass:
    48414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHST12 Gene

Post-translational modifications for CHST12 Gene

  • Ubiquitination at posLast=8686 and Lys383
  • Glycosylation at posLast=8888, Asn134, Asn209, posLast=280280, and posLast=370370
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST12 Gene

No data available for DME Specific Peptides for CHST12 Gene

Domains & Families for CHST12 Gene

Gene Families for CHST12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for CHST12 Gene

Suggested Antigen Peptide Sequences for CHST12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRB3

UniProtKB/Swiss-Prot:

CHSTC_HUMAN :
  • Belongs to the sulfotransferase 2 family.
Family:
  • Belongs to the sulfotransferase 2 family.
genes like me logo Genes that share domains with CHST12: view

Function for CHST12 Gene

Molecular function for CHST12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + chondroitin = adenosine 3,5-bisphosphate + chondroitin 4-sulfate.
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

Enzyme Numbers (IUBMB) for CHST12 Gene

Phenotypes From GWAS Catalog for CHST12 Gene

Gene Ontology (GO) - Molecular Function for CHST12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0047756 chondroitin 4-sulfotransferase activity TAS,IEA --
GO:0050656 3-phosphoadenosine 5-phosphosulfate binding NAS 10781601
genes like me logo Genes that share ontologies with CHST12: view
genes like me logo Genes that share phenotypes with CHST12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHST12

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHST12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHST12 Gene

Localization for CHST12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST12 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHST12 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHST12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane NAS 10781601
genes like me logo Genes that share ontologies with CHST12: view

Pathways & Interactions for CHST12 Gene

genes like me logo Genes that share pathways with CHST12: view

Gene Ontology (GO) - Biological Process for CHST12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0016051 carbohydrate biosynthetic process IEA --
GO:0030206 chondroitin sulfate biosynthetic process IDA,TAS --
GO:0030208 dermatan sulfate biosynthetic process IDA 10781601
genes like me logo Genes that share ontologies with CHST12: view

No data available for SIGNOR curated interactions for CHST12 Gene

Drugs & Compounds for CHST12 Gene

(1) Drugs for CHST12 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chondroitin Nutra 46

(4) Additional Compounds for CHST12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Chondroitin 4-sulfate
  • Chondroitin 4'-sulfate
  • Chondroitin 4'-sulphate
  • Chondroitin sulfate A
  • Chondroitin sulphate A
Dermatan
  • b-Heparin
  • beta-Heparin
  • Chondroitin sulfate B
  • Chondroitin sulfate type B
  • Chondroitin sulphate B
24967-94-0
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with CHST12: view

Transcripts for CHST12 Gene

Unigene Clusters for CHST12 Gene

Carbohydrate (chondroitin 4) sulfotransferase 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHST12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CHST12 Gene

No ASD Table

Relevant External Links for CHST12 Gene

GeneLoc Exon Structure for
CHST12
ECgene alternative splicing isoforms for
CHST12

Expression for CHST12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHST12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CHST12 Gene

This gene is overexpressed in Liver (57.3) and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHST12 Gene



Protein tissue co-expression partners for CHST12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHST12 Gene:

CHST12

SOURCE GeneReport for Unigene cluster for CHST12 Gene:

Hs.744987

mRNA Expression by UniProt/SwissProt for CHST12 Gene:

Q9NRB3-CHSTC_HUMAN
Tissue specificity: Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung.

Evidence on tissue expression from TISSUES for CHST12 Gene

  • Nervous system(4.3)
  • Intestine(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with CHST12: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHST12 Gene

Orthologs for CHST12 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST12 33 34
  • 99.36 (n)
rat
(Rattus norvegicus)
Mammalia Chst12 33
  • 85.19 (n)
mouse
(Mus musculus)
Mammalia Chst12 33 16 34
  • 84.3 (n)
dog
(Canis familiaris)
Mammalia CHST12 33 34
  • 83.66 (n)
cow
(Bos Taurus)
Mammalia CHST12 33 34
  • 82.72 (n)
oppossum
(Monodelphis domestica)
Mammalia CHST12 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHST12 33 34
  • 77.1 (n)
lizard
(Anolis carolinensis)
Reptilia CHST12 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chst12 33
  • 63.73 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3990 33
zebrafish
(Danio rerio)
Actinopterygii chst12a 33 34
  • 63.01 (n)
CHST12 (5 of 7) 34
  • 60 (a)
OneToMany
CHST12 (3 of 7) 34
  • 58 (a)
OneToMany
CHST12 (6 of 7) 34
  • 58 (a)
OneToMany
CHST12 (7 of 7) 34
  • 56 (a)
OneToMany
CHST12 (4 of 7) 34
  • 55 (a)
OneToMany
chst12b 34
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31743 34
  • 29 (a)
OneToMany
Species where no ortholog for CHST12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST12 Gene

ENSEMBL:
Gene Tree for CHST12 (if available)
TreeFam:
Gene Tree for CHST12 (if available)

Paralogs for CHST12 Gene

Paralogs for CHST12 Gene

(4) SIMAP similar genes for CHST12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHST12: view

Variants for CHST12 Gene

Sequence variations from dbSNP and Humsavar for CHST12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000007783 -- 2,413,408(+) TTACA(C/T)GCAAT intron-variant
rs1000102436 -- 2,423,867(+) TTCGA(A/G)ACCAG intron-variant
rs1000172983 -- 2,422,722(+) GTAGA(C/G/T)ACAGG intron-variant
rs1000246514 -- 2,422,053(+) AGTAA(C/T)GCCCT intron-variant
rs1000291207 -- 2,418,025(+) GTCAC(A/G)GTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST12 Gene

Variant ID Type Subtype PubMed ID
esv3571561 CNV loss 25503493
esv3611842 CNV loss 21293372
nsv1015743 CNV gain 25217958
nsv1032737 CNV gain 25217958
nsv1119102 CNV deletion 24896259
nsv1137186 CNV deletion 24896259
nsv950792 CNV deletion 24416366

Variation tolerance for CHST12 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHST12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHST12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST12 Gene

Disorders for CHST12 Gene

Relevant External Links for CHST12

Genetic Association Database (GAD)
CHST12
Human Genome Epidemiology (HuGE) Navigator
CHST12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHST12

No disorders were found for CHST12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHST12 Gene

Publications for CHST12 Gene

  1. Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis. (PMID: 12847091) Mikami T … Sugahara K (The Journal of biological chemistry 2003) 3 4 22 60
  2. Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. (PMID: 10781601) Hiraoka N … Fukuda M (The Journal of biological chemistry 2000) 2 3 4 60
  3. Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria. (PMID: 20580388) Valente B … Silveira H (Transactions of the Royal Society of Tropical Medicine and Hygiene 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for CHST12 Gene

Sources for CHST12 Gene

Content
Loading form....