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Aliases for CHST12 Gene

Aliases for CHST12 Gene

  • Carbohydrate (Chondroitin 4) Sulfotransferase 12 2 3
  • C4ST2 3 4 6
  • Chondroitin 4-O-Sulfotransferase 2 3 4
  • Chondroitin 4-Sulfotransferase 2 3 4
  • Sulfotransferase Hlo 3 4
  • C4ST-2 3 4
  • Carbohydrate Sulfotransferase 12 3
  • EC 2.8.2.5 4
  • C4S-2 3

External Ids for CHST12 Gene

Previous GeneCards Identifiers for CHST12 Gene

  • GC07P002153
  • GC07P002188
  • GC07P002189
  • GC07P002216
  • GC07P002409
  • GC07P002274
  • GC07P002446
  • GC07P002364
  • GC07P002447
  • GC07P002448

Summaries for CHST12 Gene

Entrez Gene Summary for CHST12 Gene

  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST12 Gene

CHST12 (Carbohydrate (Chondroitin 4) Sulfotransferase 12) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include 3-phosphoadenosine 5-phosphosulfate binding and chondroitin 4-sulfotransferase activity. An important paralog of this gene is CHST13.

UniProtKB/Swiss-Prot for CHST12 Gene

  • Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor

Gene Wiki entry for CHST12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST12 Gene

Genomics for CHST12 Gene

Regulatory Elements for CHST12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHST12 Gene

Start:
2,403,560 bp from pter
End:
2,434,607 bp from pter
Size:
31,048 bases
Orientation:
Plus strand

Genomic View for CHST12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHST12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST12 Gene

Proteins for CHST12 Gene

  • Protein details for CHST12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRB3-CHSTC_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 12
    Protein Accession:
    Q9NRB3
    Secondary Accessions:
    • A4D1Z9
    • Q502W3
    • Q9NXY7

    Protein attributes for CHST12 Gene

    Size:
    414 amino acids
    Molecular mass:
    48414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHST12 Gene

Proteomics data for CHST12 Gene at MOPED

Post-translational modifications for CHST12 Gene

  • Ubiquitination at Lys86 and Lys383
  • Glycosylation at Thr88, Asn134, Asn209, Asn280, and Asn370
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHST12 Gene

Domains for CHST12 Gene

Gene Families for CHST12 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for CHST12 Gene

Suggested Antigen Peptide Sequences for CHST12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRB3

UniProtKB/Swiss-Prot:

CHSTC_HUMAN :
  • Q9NRB3
Family:
  • Belongs to the sulfotransferase 2 family.
genes like me logo Genes that share domains with CHST12: view

Function for CHST12 Gene

Molecular function for CHST12 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + chondroitin = adenosine 3,5-bisphosphate + chondroitin 4-sulfate.
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor

Enzyme Numbers (IUBMB) for CHST12 Gene

Gene Ontology (GO) - Molecular Function for CHST12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity --
GO:0047756 chondroitin 4-sulfotransferase activity IDA 10781601
GO:0050656 3-phosphoadenosine 5-phosphosulfate binding NAS 10781601
genes like me logo Genes that share ontologies with CHST12: view

Phenotypes for CHST12 Gene

GenomeRNAi human phenotypes for CHST12:
genes like me logo Genes that share phenotypes with CHST12: view

Animal Model Products

CRISPR Products

miRNA for CHST12 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CHST12 Gene

Localization for CHST12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST12 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST12 Gene COMPARTMENTS Subcellular localization image for CHST12 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CHST12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
GO:0030173 integral component of Golgi membrane NAS 10781601
genes like me logo Genes that share ontologies with CHST12: view

Pathways for CHST12 Gene

genes like me logo Genes that share pathways with CHST12: view

Gene Ontology (GO) - Biological Process for CHST12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0016051 carbohydrate biosynthetic process IEA --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHST12: view

Compounds for CHST12 Gene

(5) HMDB Compounds for CHST12 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Chondroitin
  • Chondroitin-D-glucuronate
9007-27-6
Chondroitin 4-sulfate
  • Chondroitin 4'-sulfate
Not Available
Dermatan
  • Chondroitin sulfate B
24967-94-0
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(1) Novoseek inferred chemical compound relationships for CHST12 Gene

Compound -log(P) Hits PubMed IDs
chondroitin 85.6 2
genes like me logo Genes that share compounds with CHST12: view

Transcripts for CHST12 Gene

Unigene Clusters for CHST12 Gene

Carbohydrate (chondroitin 4) sulfotransferase 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHST12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST12 Gene

No ASD Table

Relevant External Links for CHST12 Gene

GeneLoc Exon Structure for
CHST12
ECgene alternative splicing isoforms for
CHST12

Expression for CHST12 Gene

mRNA expression in normal human tissues for CHST12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHST12 Gene

SOURCE GeneReport for Unigene cluster for CHST12 Gene Hs.744987

mRNA Expression by UniProt/SwissProt for CHST12 Gene

Q9NRB3-CHSTC_HUMAN
Tissue specificity: Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung.
genes like me logo Genes that share expressions with CHST12: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CHST12 Gene

Orthologs for CHST12 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST12 35
  • 99.36 (n)
  • 99.76 (a)
CHST12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHST12 35
  • 82.72 (n)
  • 78.24 (a)
CHST12 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHST12 35
  • 83.66 (n)
  • 82.04 (a)
CHST12 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chst12 35
  • 84.3 (n)
  • 84.71 (a)
Chst12 16
Chst12 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHST12 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chst12 35
  • 85.19 (n)
  • 84.22 (a)
chicken
(Gallus gallus)
Aves CHST12 35
  • 77.1 (n)
  • 78.4 (a)
CHST12 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST12 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3990 35
tropical clawed frog
(Silurana tropicalis)
Amphibia chst12 35
  • 63.73 (n)
  • 67.97 (a)
zebrafish
(Danio rerio)
Actinopterygii CHST12 (3 of 7) 36
  • 58 (a)
OneToMany
CHST12 (4 of 7) 36
  • 55 (a)
OneToMany
CHST12 (5 of 7) 36
  • 60 (a)
OneToMany
CHST12 (6 of 7) 36
  • 58 (a)
OneToMany
CHST12 (7 of 7) 36
  • 56 (a)
OneToMany
chst12a 35
  • 63.01 (n)
  • 61.46 (a)
chst12a 36
  • 58 (a)
OneToMany
chst12b 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31743 36
  • 29 (a)
OneToMany
Species with no ortholog for CHST12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST12 Gene

ENSEMBL:
Gene Tree for CHST12 (if available)
TreeFam:
Gene Tree for CHST12 (if available)

Paralogs for CHST12 Gene

Paralogs for CHST12 Gene

Selected SIMAP similar genes for CHST12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHST12: view

Variants for CHST12 Gene

Sequence variations from dbSNP and Humsavar for CHST12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1004642 -- 2,404,194(+) CGCCA(G/T)CAGCA intron-variant
rs1548593 -- 2,434,408(+) GATTT(C/T)TAGGA utr-variant-3-prime
rs1946119 -- 2,420,990(-) AGCTA(A/C)TCAAG intron-variant
rs2023968 -- 2,411,826(-) CAAAC(A/G)ATAAC intron-variant
rs2023969 -- 2,410,345(-) ACACC(A/G)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST12 Gene

Variant ID Type Subtype PubMed ID
dgv7116n71 CNV Loss 21882294
nsv887282 CNV Loss 21882294
dgv7117n71 CNV Loss 21882294

Relevant External Links for CHST12 Gene

HapMap Linkage Disequilibrium report
CHST12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST12 Gene

Disorders for CHST12 Gene

Relevant External Links for CHST12

Genetic Association Database (GAD)
CHST12
Human Genome Epidemiology (HuGE) Navigator
CHST12
genes like me logo Genes that share disorders with CHST12: view

No data available for UniProtKB/Swiss-Prot for CHST12 Gene

Publications for CHST12 Gene

  1. Specificities of three distinct human chondroitin/dermatan N- acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor. Implication of differential roles in dermatan sulfate biosynthesis. (PMID: 12847091) Mikami T. … Sugahara K. (J. Biol. Chem. 2003) 3 4 23
  2. Molecular cloning and expression of two distinct human chondroitin 4- O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. (PMID: 10781601) Hiraoka N. … Fukuda M. (J. Biol. Chem. 2000) 2 3 4
  3. Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria. (PMID: 20580388) Valente B. … Silveira H. (Trans. R. Soc. Trop. Med. Hyg. 2010) 3 48
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for CHST12 Gene

Sources for CHST12 Gene

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