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CHST12 Gene

protein-coding   GIFtS: 54
GCID: GC07P002448

Carbohydrate (Chondroitin 4) Sulfotransferase 12

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbohydrate (Chondroitin 4) Sulfotransferase 121 2     C4ST-22 3
C4ST22 3 5     C4S-22
Chondroitin 4-O-Sulfotransferase 22 3     Carbohydrate Sulfotransferase 122
Chondroitin 4-Sulfotransferase 22 3     EC 2.8.2.53
Sulfotransferase Hlo2 3     

External Ids:    HGNC: 174231   Entrez Gene: 555012   Ensembl: ENSG000001362137   OMIM: 6101295   UniProtKB: Q9NRB33   

Export aliases for CHST12 gene to outside databases

Previous GC identifers: GC07P002153 GC07P002188 GC07P002189 GC07P002216 GC07P002409 GC07P002274 GC07P002446 GC07P002364 GC07P002447


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHST12 Gene:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane,
and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin
and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in
cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced
transcript variants differing only in their 5' UTRs have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for CHST12 Gene:
CHST12 (carbohydrate (chondroitin 4) sulfotransferase 12) is a protein-coding gene. Diseases associated with CHST12 include morquio syndrome b, and sly syndrome. GO annotations related to this gene include 3'-phosphoadenosine 5'-phosphosulfate binding and chondroitin 4-sulfotransferase activity. An important paralog of this gene is CHST13.

UniProtKB/Swiss-Prot: CHSTC_HUMAN, Q9NRB3
Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of
chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present
in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward
partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin
sulfate C is used as an acceptor

Gene Wiki entry for CHST12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CHST12 gene promoter:
         Tal-1beta   RORalpha2   Roaz   E47   YY1   c-Ets-1   Max   IRF-7A   ZID   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHST12 promoter sequence
   Search Chromatin IP Primers for CHST12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHST12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

CHST12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST12 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P002448:  view genomic region     (about GC identifiers)

Start:
2,443,223 bp from pter      End:
2,474,242 bp from pter
Size:
31,020 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 2,491,153-2,522,134     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHSTC_HUMAN, Q9NRB3 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 12  
Size: 414 amino acids; 48414 Da
Secondary accessions: A4D1Z9 Q502W3 Q9NXY7

Explore the universe of human proteins at neXtProt for CHST12: NX_Q9NRB3

Explore proteomics data for CHST12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys86, Lys383
  • Glycosylation2 at Thr88, Asn134, Asn209, Asn280, Asn370
  • Modification sites at PhosphoSitePlus

  • See CHST12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230723.1  NP_001230724.1  NP_061111.1  

    ENSEMBL proteins: 
     ENSP00000258711   ENSP00000411207  
    Reactome Protein details: Q9NRB3

    CHST12 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for CHST12
    OriGene Custom Protein Services for CHST12
    GenScript Custom Purified and Recombinant Proteins Services for CHST12
    Novus Biologicals CHST12 Proteins
    Novus Biologicals CHST12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHST12

    CHST12 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CHST12
    Cloud-Clone Corp. Antibodies for CHST12
    Search ThermoFisher Antibodies for CHST12
    Search LSBio for Antibodies for CHST12

    CHST12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CHST12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHST12
    Cloud-Clone Corp. CLIAs for CHST12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR005331 Sulfotransferase
     IPR018011 Carb_sulfotransferase-rel

    Graphical View of Domain Structure for InterPro Entry Q9NRB3

    ProtoNet protein and cluster: Q9NRB3

    UniProtKB/Swiss-Prot: CHSTC_HUMAN, Q9NRB3
    Similarity: Belongs to the sulfotransferase 2 family


    CHST12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHSTC_HUMAN, Q9NRB3
    Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of
    chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present
    in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward
    partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin
    sulfate C is used as an acceptor
    Catalytic activity: 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin
    4'-sulfate

         Enzyme Number (IUBMB): EC 2.8.2.51

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0047756chondroitin 4-sulfotransferase activity IDA10781601
    GO:00506563'-phosphoadenosine 5'-phosphosulfate binding NAS10781601
         
    CHST12 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHST12:
     Decreased Hepatitis C virus re 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHST12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHST12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST12

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHST12:
    hsa-mir-26b-5p (MIRT030347), hsa-mir-192-5p (MIRT026953), hsa-mir-215-5p (MIRT024916), hsa-mir-122-5p (MIRT023383)

    Block miRNA regulation of human, mouse, rat CHST12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST12 (see all 9):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-34a hsa-miR-338-5p hsa-miR-656 hsa-miR-508-5p hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHST12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHST12
    Predesigned siRNA for gene silencing in human, mouse, rat CHST12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHST12

    Clone
    Products:
         
    OriGene clones in human, mouse for CHST12 (see all 5)
    OriGene ORF clones in mouse, rat for CHST12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHST12 (NM_018641)
    Sino Biological Human cDNA Clone for CHST12
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST12

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHST12
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHST12 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHSTC_HUMAN, Q9NRB3: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane ----
    GO:0030173integral component of Golgi membrane NAS10781601

    CHST12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHST12 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.00
    Chondroitin sulfate biosynthesis0.41
    3Biological oxidations
    metapathway biotransformation0.42
    4Metabolism
    Metabolism0.38
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for CHST12
        chondroitin sulfate biosynthesis (late stages)
    metapathway biotransformation
    chondroitin sulfate biosynthesis


    1 Reactome Pathway for CHST12
        Chondroitin sulfate biosynthesis


    1 Kegg Pathway  (Kegg details for CHST12):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate


    CHST12 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHST12
    Interactions:

        Search GeneGlobe Interaction Network for CHST12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CHST12 (Q9NRB31, 3 ENSP000002587114) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UGGT1Q9NYU21, 3, ENSP000002592534EBI-1042837,EBI-1056389 I2D: score=2 STRING: ENSP00000259253
    BGNENSP000003273364STRING: ENSP00000327336
    CHPFENSP000002437764STRING: ENSP00000243776
    CHST15ENSP000003339474STRING: ENSP00000333947
    CHST3ENSP000003622074STRING: ENSP00000362207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0016051carbohydrate biosynthetic process IEA--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0030206chondroitin sulfate biosynthetic process TAS--

    CHST12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHST12 (CHSTC)

    5 HMDB Compounds for CHST12    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    Chondroitin 4-sulfateChondroitin 4'-sulfate (see all 2)----
    DermatanChondroitin sulfate B (see all 13)24967-94-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    1 Novoseek inferred chemical compound relationship for CHST12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 85.6 6 16118286 (1), 10988300 (1)



    CHST12 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHST12 gene (3 alternative transcripts): 
    NM_001243794.1  NM_001243795.1  NM_018641.4  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258711(uc003smc.3 uc003smd.3 uc021zyu.1) ENST00000432336

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHST12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST12 (see all 9):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-34a hsa-miR-338-5p hsa-miR-656 hsa-miR-508-5p hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHST12 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHST12
    Predesigned siRNA for gene silencing in human, mouse, rat CHST12
    Clone
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    OriGene clones in human, mouse for CHST12 (see all 5)
    OriGene ORF clones in mouse, rat for CHST12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHST12 (NM_018641)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST12
    Primer
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    OriGene qPCR primer pairs and template standards for CHST12
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST12
      QuantiTect SYBR Green Assays in human, mouse, rat CHST12
      QuantiFast Probe-based Assays in human, mouse, rat CHST12

    Selected AceView cDNA sequences (see all 99):

    BU538747 BE407252 BE276749 AW292663 AA583629 BX095157 CB992553 BM677270 
    BP339538 AI648561 AI343334 BM721669 AA252149 AA449539 CR615984 BQ709597 
    AW135558 BI828898 BQ213557 AA252298 AI872887 AA449104 BP340554 AJ289131 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHST12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCGGCTGT
    CHST12 Expression
    About this image


    CHST12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     Hair (Integumentary System)
             Outer Root Sheath Cells Outer Root Sheath
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
    CHST12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHST12 Protein Expression

    UniProtKB/Swiss-Prot: CHSTC_HUMAN, Q9NRB3
    Tissue specificity: Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary
    gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and
    fetal lung

        Custom PCR Arrays for CHST12
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST12
    QuantiTect SYBR Green Assays in human, mouse, rat CHST12
    QuantiFast Probe-based Assays in human, mouse, rat CHST12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHST12 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst121 , 5 carbohydrate sulfotransferase 121, 5 84.3(n)1
    84.71(a)1
      5 (79.04 cM)5
    590311  NM_021528.31  NP_067503.31 
     1405055505 
    chicken
    (Gallus gallus)
    Aves CHST121 carbohydrate (chondroitin 4) sulfotransferase 12 77.1(n)
    78.4(a)
      416469  XM_004945140.1  XP_004945197.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHST126
    carbohydrate (chondroitin 4) sulfotransferase 12
    75(a)
    1 ↔ 1
    GL343340.1(68338-69612)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.39902 Xenopus laevis transcribed sequence with weak similarity more 73.22(n)    48046065 
    zebrafish
    (Danio rerio)
    Actinopterygii chst12a1 carbohydrate (chondroitin 4) sulfotransferase 12a 63.01(n)
    61.46(a)
      407076  NM_213547.2  NP_998712.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG317436
    --
    29(a)
    1 → many
    2L(16879517-16886323)


    ENSEMBL Gene Tree for CHST12 (if available)
    TreeFam Gene Tree for CHST12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHST12 gene
    CHST132  CHST92  CHST112  CHST102  CHST82  CHST142  
    4 SIMAP similar genes for CHST12 using alignment to 2 protein entries:     CHSTC_HUMAN (see all proteins):
    CHST11    CHST9    CHST13    CHST8

    CHST12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHST12 (see all 818)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1489376441,2
    --2413471(+) ACTTCA/GGCCTC 3 -- us2k10--------
    rs1915397871,2
    --2413502(+) GTGTGA/CGCCAC 3 -- us2k10--------
    rs559707421,2
    C,F--2413514(+) GCACAT/CGGCTG 3 -- us2k110Minor allele frequency- C:0.34WA NA CSA EA 372
    rs1436637811,2
    C--2413559(+) CAGGGC/TGACAT 3 -- us2k10--------
    rs1154038821,2
    C,F--2413589(+) ATTTAC/TATACG 3 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1837462321,2
    C--2413592(+) TACATA/GCGTGC 3 -- us2k10--------
    rs1888593341,2
    --2413611(+) ATATGA/TATGTA 3 -- us2k10--------
    rs765791991,2
    C,F--2413642(+) CATGCA/GTAATA 3 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1812848361,2
    --2413648(+) TAATAA/CAGGTC 3 -- us2k10--------
    rs1145807731,2
    F--2413718(+) TATGCA/CTTACA 3 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for CHST12 (2443223 - 2474242 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CHST12:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7117n71CNV Loss21882294
    nsv887282CNV Loss21882294
    dgv7116n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CHST12
    DNA2.0 Custom Variant and Variant Library Synthesis for CHST12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610129    OMIM disorders: --

    6 diseases for CHST12:    
    About MalaCards
    morquio syndrome b    sly syndrome    mucopolysaccharidoses    malaria
    multiple sclerosis    thyroiditis


    CHST12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHST12
    Human Genome Epidemiology (HuGE) Navigator: CHST12 (1 document)

    Export disorders for CHST12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHST12 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with CHST12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of two distinct human chondroitin 4- O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. (PubMed id 10781601)1, 2, 3 Hiraoka N.... Fukuda M. (J. Biol. Chem. 2000)
    2. Specificities of three distinct human chondroitin/dermatan N- acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor. Implication of differential roles in dermatan sulfate biosynthesis. (PubMed id 12847091)1, 2, 9 Mikami T.... Sugahara K. (J. Biol. Chem. 2003)
    3. Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria. (PubMed id 20580388)1, 4 Valente B....Silveira H. (Trans. R. Soc. Trop. Med. Hyg. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (Nature 2011)
    10. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55501 HGNC: 17423 AceView: CHST12 Ensembl:ENSG00000136213 euGenes: HUgn55501
    ECgene: CHST12 Kegg: 55501 H-InvDB: CHST12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CHST12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CHST12 gene:
    Search GeneIP for patents involving CHST12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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