Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHST11 Gene

protein-coding   GIFtS: 57
GCID: GC12P104849

Carbohydrate (Chondroitin 4) Sulfotransferase 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carbohydrate (Chondroitin 4) Sulfotransferase 111 2     C4ST2
Chondroitin 4-O-Sulfotransferase 12 3     HSA2695372
C4S-12 3     Carbohydrate Sulfotransferase 112
C4ST-12 3     IgH/CHST11 Fusion2
C4ST12 3     Chondroitin 4-Sulfotransferase 13
EC 2.8.2.53 8     

External Ids:    HGNC: 174221   Entrez Gene: 505152   Ensembl: ENSG000001713107   OMIM: 6101285   UniProtKB: Q9NPF23   

Export aliases for CHST11 gene to outside databases

Previous GC identifers: GC12P104783 GC12P103353 GC12P103351 GC12P101909


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHST11 Gene:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane,
and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin.
Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the
surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH,
t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for CHST11 Gene: 
CHST11 (carbohydrate (chondroitin 4) sulfotransferase 11) is a protein-coding gene. Diseases associated with CHST11 include b-cell chronic lymphocytic leukemia, and chronic lymphocytic leukemia, and among its related super-pathways are Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate and Metabolism of carbohydrates. GO annotations related to this gene include N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity and N-acetylgalactosamine 4-O-sulfotransferase activity. An important paralog of this gene is CHST12.

UniProtKB/Swiss-Prot: CHSTB_HUMAN, Q9NPF2
Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of
chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed
on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan
sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated
GalNAc when chondroitin sulfate C is used as an acceptor

Gene Wiki entry for CHST11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHST11 gene promoter:
         NF-1   AML1a   MyoD   XBP-1   Nkx2-5   YY1   GATA-1   C/EBPalpha   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST11 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHST11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

CHST11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST11 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P104849:  view genomic region     (about GC identifiers)

Start:
104,849,073 bp from pter      End:
105,155,792 bp from pter
Size:
306,720 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHSTB_HUMAN, Q9NPF2 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 11  
Size: 352 amino acids; 41555 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: A8K4F8 Q9NXY6 Q9NY36
Alternative splicing: 2 isoforms:  Q9NPF2-1   Q9NPF2-2   

Explore the universe of human proteins at neXtProt for CHST11: NX_Q9NPF2

Explore proteomics data for CHST11 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated; required for activity and stability
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPF2

  • 4/7 DME Specific Peptides for CHST11 (Q9NPF2) (see all 7)
     CCRKGSR  AKSTRTTD  PVMRRNPF  YCYVPKVAC 

    CHST11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHST11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001167453.1  NP_060883.1  

    ENSEMBL proteins: 
     ENSP00000449093   ENSP00000450004   ENSP00000305725   ENSP00000448678   ENSP00000449095  
    Reactome Protein details: Q9NPF2
    Human Recombinant Protein Products for CHST11: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CHST11
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CHST11
    GenScript Custom Purified and Recombinant Proteins Services for CHST11
    Novus Biologicals CHST11 Protein
    Novus Biologicals CHST11 Lysate
    Sino Biological Recombinant Protein for CHST11
    Sino Biological Cell Lysate for CHST11 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHST11 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane NAS11056388

    CHST11 for ontologies           About GeneDecksing



    CHST11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CHST11
    GenScript Custom Superior Antibodies Services for CHST11
    Novus Biologicals CHST11 Antibodies
    Abcam antibodies for CHST11
    Cloud-Clone Corp. Antibodies for CHST11 
    Search ThermoFisher Antibodies for CHST11
    LSBio Antibodies in human, mouse, rat for CHST11 

    Assay Products for CHST11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHST11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHST11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHST11 
    Cloud-Clone Corp. CLIAs for CHST11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR005331 Sulfotransferase
     IPR018011 Carb_sulfotransferase-rel

    Graphical View of Domain Structure for InterPro Entry Q9NPF2

    ProtoNet protein and cluster: Q9NPF2

    UniProtKB/Swiss-Prot: CHSTB_HUMAN, Q9NPF2
    Similarity: Belongs to the sulfotransferase 2 family


    CHST11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHSTB_HUMAN, Q9NPF2
    Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of
    chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed
    on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan
    sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated
    GalNAc when chondroitin sulfate C is used as an acceptor
    Catalytic activity: 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin
    4'-sulfate
    Biophysicochemical properties: Kinetic parameters: KM=0.5 uM for PAPS; KM=2.1 mM for chondroitin;

         Enzyme Number (IUBMB): EC 2.8.2.51 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001537N-acetylgalactosamine 4-O-sulfotransferase activity IDA11056388
    GO:0008146sulfotransferase activity ----
    GO:0047756chondroitin 4-sulfotransferase activity IDA11056388
    GO:0050659N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IEA--
         
    CHST11 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chst11):
     craniofacial  growth/size  limbs/digits/tail  mortality/aging  respiratory system 
     skeleton 

    CHST11 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHST11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHST11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST11 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHST11:
    hsa-mir-1 (MIRT002789)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST11
    8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST11 (see all 82):
    hsa-miR-26a-2* hsa-miR-4254 hsa-miR-607 hsa-miR-519a hsa-miR-1273d hsa-miR-509-3-5p hsa-miR-130b hsa-miR-3690
    SwitchGear 3'UTR luciferase reporter plasmidCHST11 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHST11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHST11
    Sirion Biotech Customized adenovirus for overexpression of CHST11

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CHST11 (see all 10)
    OriGene ORF clones in mouse, rat for CHST11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CHST11 (NM_018413)
    Sino Biological Human cDNA Clone for CHST11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST11
    Sirion Biotech Customized lentivirus for stable overexpression of CHST11 
                         Customized lentivirus expression plasmids for stable overexpression of CHST11 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHST11
    Search LifeMap BioReagents cell lines for CHST11
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHST11 About   (see all 8)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1chondroitin sulfate biosynthesis
    chondroitin sulfate biosynthesis0.74
    chondroitin sulfate biosynthesis (late stages)0.65
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.74
    Chondroitin sulfate biosynthesis0.50
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Mucopolysaccharidoses0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS IV - Morquio syndrome B0.48
    MPS I - Hurler syndrome0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS IX - Natowicz syndrome0.48
    3A tetrasaccharide linker sequence is required for GAG synthesis
    Chondroitin sulfate/dermatan sulfate metabolism0.54
    4Biological oxidations
    metapathway biotransformation0.41
    5Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for CHST11
        Spinal Cord Injury
    Endochondral Ossification
    chondroitin sulfate biosynthesis (late stages)
    metapathway biotransformation
    chondroitin sulfate biosynthesis


    5/18        Reactome Pathways for CHST11 (see all 18)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS II - Hunter syndrome


    1         Kegg Pathway  (Kegg details for CHST11):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate


    CHST11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHST11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for CHST11 (ENSP000003057254) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCANENSP000003312104STRING: ENSP00000331210
    BGNENSP000003273364STRING: ENSP00000327336
    BPNT1ENSP000003188524STRING: ENSP00000318852
    CHPFENSP000002437764STRING: ENSP00000243776
    CHST15ENSP000003339474STRING: ENSP00000333947
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002063chondrocyte development IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007585respiratory gaseous exchange IEA--
    GO:0009791post-embryonic development IEA--
    GO:0016051carbohydrate biosynthetic process IEA--

    CHST11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHST11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHST11 (CHSTB)

    5 HMDB Compounds for CHST11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    Chondroitin 4-sulfateChondroitin 4'-sulfate (see all 2)----
    DermatanChondroitin sulfate B (see all 13)24967-94-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    7 Novoseek inferred chemical compound relationships for CHST11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 92.4 52 1751554 (4), 11056388 (3), 16079159 (3), 10722746 (2) (see all 11)
    dermatan sulfate 76.7 2 12847091 (1)
    chondroitin sulfate 76.5 6 12847091 (1), 19915053 (1), 17597120 (1), 16079159 (1)
    3-phosphoadenosine 5'-phosphosulfate 71.9 4 11056388 (1), 10722746 (1)
    sulfate 70.3 8 11056388 (1), 10722746 (1), 16079159 (1)
    heparan sulfate 45.5 2 17113869 (1)
    polysaccharide 34.2 1 17113869 (1)

    Search CenterWatch for drugs/clinical trials and news about CHST11 / CHSTB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHST11 gene (2 alternative transcripts): 
    NM_001173982.1  NM_018413.5  

    Unigene Cluster for CHST11:

    Carbohydrate (chondroitin 4) sulfotransferase 11
    Hs.17569  [show with all ESTs]
    Unigene Representative Sequence: NM_018413
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550711 ENST00000547956 ENST00000549260(uc001tky.3) ENST00000303694(uc001tkz.3)
    ENST00000546689 ENST00000549016
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST11
    8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST11 (see all 82):
    hsa-miR-26a-2* hsa-miR-4254 hsa-miR-607 hsa-miR-519a hsa-miR-1273d hsa-miR-509-3-5p hsa-miR-130b hsa-miR-3690
    SwitchGear 3'UTR luciferase reporter plasmidCHST11 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHST11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST11
    Clone
    Products:
         
    OriGene clones in human, mouse for CHST11 (see all 10)
    OriGene ORF clones in mouse, rat for CHST11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CHST11 (NM_018413)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST11
    Sirion Biotech Customized lentivirus for stable overexpression of CHST11 
                         Customized lentivirus expression plasmids for stable overexpression of CHST11 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHST11
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHST11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST11

    Additional mRNA sequence: 

    AB042326.1 AF131762.1 AF239820.1 AJ269537.2 AJ289134.1 AK123676.1 AK290923.1 AK313217.1 
    AL833176.1 AY533204.1 AY533205.1 BC013315.1 BC030271.1 BC061524.1 

    5 DOTS entries:

    DT.97765459  DT.100784578  DT.100784575  DT.121137744  DT.91649628 

    24/154 AceView cDNA sequences (see all 154):

    BQ001178 AW593088 BU168918 BU174298 CR608680 AA465726 BU168787 BQ006916 
    AW961343 AB042326 CA309228 CD364688 CD676264 BC061524 AA634815 AF131762 
    CB529524 BU838915 BM763953 AA305693 BQ877457 CD367266 BQ009789 AJ289134 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CHST11    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
    SP1:              -           -         
    SP2:                          -         
    SP3:              -                     
    SP4:                                    


    ECgene alternative splicing isoforms for CHST11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHST11 expression in normal human tissues (normalized intensities)      CHST11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHST11 Expression
    About this image


    CHST11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Blood (Hematopoietic System)
             mouse/organ system/cardiovascular system   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See CHST11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHST11

    SOURCE GeneReport for Unigene cluster: Hs.17569

    UniProtKB/Swiss-Prot: CHSTB_HUMAN, Q9NPF2
    Tissue specificity: Widely expressed. Highly expressed in spleen, thymus, bone marrow, peripheral blood
    leukocytes, lymph node, heart, brain, lung and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including CHST11: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHST11
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHST11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHST11 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst111 , 5 carbohydrate sulfotransferase 111, 5 90.87(n)1
    96.54(a)1
      10 (40.66 cM)5
    582501  NM_021439.21  NP_067414.21 
     829854985 
    chicken
    (Gallus gallus)
    Aves CHST111 carbohydrate (chondroitin 4) sulfotransferase 11 84.93(n)
    93.91(a)
      418081  XM_416316.3  XP_416316.3 
    lizard
    (Anolis carolinensis)
    Reptilia CHST116
    Uncharacterized protein
    94(a)
    1 ↔ 1
    5(18382200-18612086)
    African clawed frog
    (Xenopus laevis)
    Amphibia chst11-prov2 carbohydrate sulfotransferase 11 72.65(n)    BC056117.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chst111 carbohydrate (chondroitin 4) sulfotransferase 11 75.31(n)
    78.67(a)
      404232  NM_212824.2  NP_997989.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG317431 CG31743 51.02(n)
    39.71(a)
      326156  NM_135976.2  NP_609820.1 


    ENSEMBL Gene Tree for CHST11 (if available)
    TreeFam Gene Tree for CHST11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHST11 gene
    CHST122  CHST132  CHST92  CHST102  CHST82  CHST142  
    6 SIMAP similar genes for CHST11 using alignment to 4 protein entries:     CHSTB_HUMAN (see all proteins):
    CHST13    CHST9    CHST8    CHST12    CHST10    CHST14

    CHST11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6407 SNPs in CHST11 are shown (see all 6407)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011407771,2
    Cuntested1104991503(+) CCAACA/GAGGCA 4 K E mis10--------
    rs784400191,2
    C--101910351(+) TTCTTT/CTTTTT 2 -- int12Minor allele frequency- C:0.25WA 4
    rs1118920861,2
    C--101928213(+) TATATA/TTATTT 2 -- int10--------
    rs1128065941,2
    C--101934374(+) TTGCAT/-TTTTT 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs710697591,2
    C--101934880(-) TTTGC-/CG/G  
            
    GGGGG
    2 -- int11NA 2
    rs113335861,2
    C--101934881(+) CCCCCG/-CAAAA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs768863351,2
    C--101934881(+) CCCCCC/GCAAAA 2 -- int10--------
    rs58006231,2
    C--101951940(+) CAGGT-/ACCTGG 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs339830861,2
    C--101951942(+) AGGTC-/ACTGGG 2 -- int10--------
    rs123709441,2
    C--101965651(+) ACTGGG/TGGGGG 2 -- int1 trp31Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for CHST11 (104849073 - 105099073 bp, first 250kb of CHST11)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for CHST11 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746317CNV Deletion23290073
    esv2661506CNV Deletion23128226
    esv2746318CNV Deletion23290073
    esv26567CNV Loss19812545
    nsv899497CNV Loss21882294
    esv25429CNV Loss19812545
    nsv832502CNV Loss17160897
    nsv868CNV Loss18451855
    nsv515742CNV Loss19592680
    nsv899496CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CHST11
    DNA2.0 Custom Variant and Variant Library Synthesis for CHST11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610128    OMIM disorders: --

    UniProtKB/Swiss-Prot: CHSTB_HUMAN, Q9NPF2
  • Note=A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias.
    Translocation t(12;14)(q23;q32) with IgH

  • 11 diseases for CHST11:    About MalaCards
    b-cell chronic lymphocytic leukemia    chronic lymphocytic leukemia    costello syndrome    cutaneous lupus erythematosus
    morquio syndrome b    leukemia    malaria    lupus erythematosus
    prostate cancer    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CHST11:
    Cutaneous lupus erythematosus

    CHST11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHST11
    Human Genome Epidemiology (HuGE) Navigator: CHST11 (5 documents)

    Export disorders for CHST11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHST11 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with CHST11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of two distinct human chondroitin 4- O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. (PubMed id 10781601)1, 2, 3 Hiraoka N.... Fukuda M. (2000)
    2. Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. (PubMed id 11056388)1, 2, 9 Okuda T.... Habuchi O. (2000)
    3. Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32). (PubMed id 15273723)1, 2, 9 Schmidt H.H.... Chaganti R.S.K. (2004)
    4. Specificities of three distinct human chondroitin/dermatan N- acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor. Implication of differential roles in dermatan sulfate biosynthesis. (PubMed id 12847091)1, 2, 9 Mikami T.... Sugahara K. (2003)
    5. A genome-wide association study of DSM-IV cannabis dep endence. (PubMed id 21668797)1, 4 Agrawal A....Bierut L.J. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (2010)
    8. Natural frequency of polymorphisms linked to the chon droitin 4-sulfotransferase genes and its association with placental malaria. (PubMed id 20580388)1, 4 Valente B....Silveira H. (2010)
    9. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    10. N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1. (PubMed id 15628971)1, 2 Yusa A.... Habuchi O. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50515 HGNC: 17422 AceView: CHST11 Ensembl:ENSG00000171310 euGenes: HUgn50515
    ECgene: CHST11 Kegg: 50515 H-InvDB: CHST11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHST11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHST11 gene:
    Search GeneIP for patents involving CHST11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CHST11  
     OriGene qPCR primer pairs and template standards for CHST11   OriGene Protein Over-expression Lysate for CHST11  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CHST11  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHST11   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CHST11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHST11   OriGene Custom Protein Services for CHST11  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHST11
     QIAGEN SeqTarget long-range PCR primers for resequencing CHST11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST11
     GenScript Custom Purified and Recombinant Proteins Services for CHST11 GenScript cDNA clones with any tag delivered in your preferred vector for CHST11
     GenScript Custom Assay Services for CHST11 GenScript Custom Superior Antibodies Services for CHST11
     GenScript Custom overexpressing Cell Line Services for CHST11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CHST11 promoter
     Search Chromatin IP Primers for CHST11
     RT2 qPCR Primer Assay in human, mouse, rat CHST11
     Search GNC Networks for CHST11
     SABiosciences PCR Arrays including human, mouse, rat CHST11
     Search Tocris compounds for CHST11 (CHSTB)
     Proteins and Antibodies for CHST11
     Cell Lysates for CHST11
     cDNA Clones for CHST11
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CHST11 antibodies
     CHST11 proteins
     CHST11 lysates
     Antibodies for CHST11
     See all of Abcam's Antibodies, Kits and Proteins for CHST11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CHST11
     Antibodies for CHST11
     ELISAs for CHST11
     CLIAs for CHST11
     Search LifeMap BioReagents cell lines for CHST11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST11
     SwitchGear 3'UTR luciferase reporter plasmids for CHST11
     SwitchGear Promoter luciferase reporter plasmids for CHST11
     Search ThermoFisher Antibodies for CHST11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST11
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CHST11
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHST11
    Customized:
     lentivirus for stable overexpression of CHST11
     lentivirus expression plasmids for stable overexpression of CHST11
     adenovirus for overexpression of CHST11
     LSBio Antibodies in human, mouse, rat for CHST11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHST11 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4