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CHST11 Gene

protein-coding   GIFtS: 56
GCID: GC12P104849

Carbohydrate (Chondroitin 4) Sulfotransferase 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbohydrate (Chondroitin 4) Sulfotransferase 111 2     C4ST2
Chondroitin 4-O-Sulfotransferase 12 3     HSA2695372
C4S-12 3     Carbohydrate Sulfotransferase 112
C4ST-12 3     IgH/CHST11 Fusion2
C4ST12 3     Chondroitin 4-Sulfotransferase 13
EC 2.8.2.53 8     

External Ids:    HGNC: 174221   Entrez Gene: 505152   Ensembl: ENSG000001713107   OMIM: 6101285   UniProtKB: Q9NPF23   

Export aliases for CHST11 gene to outside databases

Previous GC identifers: GC12P104783 GC12P103353 GC12P103351 GC12P101909


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHST11 Gene:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane,
and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin.
Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the
surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH,
t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for CHST11 Gene:
CHST11 (carbohydrate (chondroitin 4) sulfotransferase 11) is a protein-coding gene. Diseases associated with CHST11 include chronic lymphocytic leukemia, and b-cell chronic lymphocytic leukemia. GO annotations related to this gene include N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity and N-acetylgalactosamine 4-O-sulfotransferase activity. An important paralog of this gene is CHST12.

UniProtKB/Swiss-Prot: CHSTB_HUMAN, Q9NPF2
Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of
chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed
on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan
sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated
GalNAc when chondroitin sulfate C is used as an acceptor

Gene Wiki entry for CHST11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHST11 gene promoter:
         NF-1   AML1a   MyoD   XBP-1   Nkx2-5   YY1   GATA-1   C/EBPalpha   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST11 promoter sequence
   Search Chromatin IP Primers for CHST11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHST11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

CHST11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST11 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P104849:  view genomic region     (about GC identifiers)

Start:
104,849,073 bp from pter      End:
105,155,792 bp from pter
Size:
306,720 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHSTB_HUMAN, Q9NPF2 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 11  
Size: 352 amino acids; 41555 Da
Secondary accessions: A8K4F8 Q9NXY6 Q9NY36
Alternative splicing: 2 isoforms:  Q9NPF2-1   Q9NPF2-2   

Explore the universe of human proteins at neXtProt for CHST11: NX_Q9NPF2

Explore proteomics data for CHST11 at MOPED

Post-translational modifications: 

  • N-glycosylated; required for activity and stability1
  • Glycosylation2 at Asn205, Asn223, Asn321, Asn342
  • Selected DME Specific Peptides for CHST11 (Q9NPF2) (see all 7)
     CCRKGSR  AKSTRTTD  PVMRRNPF  YCYVPKVAC 


    See CHST11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001167453.1  NP_060883.1  

    ENSEMBL proteins: 
     ENSP00000449093   ENSP00000450004   ENSP00000305725   ENSP00000448678   ENSP00000449095  
    Reactome Protein details: Q9NPF2

    CHST11 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CHST11
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    Novus Biologicals CHST11 Protein
    Novus Biologicals CHST11 Lysate
    Sino Biological Recombinant Protein for CHST11
    Sino Biological Cell Lysate for CHST11
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHST11

    CHST11 Antibody Products:

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    Abcam antibodies for CHST11
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    LSBio Antibodies in human, mouse, rat for CHST11

    CHST11 Assay Products:

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    Cloud-Clone Corp. ELISAs for CHST11
    Cloud-Clone Corp. CLIAs for CHST11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR005331 Sulfotransferase
     IPR018011 Carb_sulfotransferase-rel

    Graphical View of Domain Structure for InterPro Entry Q9NPF2

    ProtoNet protein and cluster: Q9NPF2

    UniProtKB/Swiss-Prot: CHSTB_HUMAN, Q9NPF2
    Similarity: Belongs to the sulfotransferase 2 family


    CHST11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHSTB_HUMAN, Q9NPF2
    Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of
    chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed
    on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan
    sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated
    GalNAc when chondroitin sulfate C is used as an acceptor
    Catalytic activity: 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin
    4'-sulfate
    Biophysicochemical properties: Kinetic parameters: KM=0.5 uM for PAPS; KM=2.1 mM for chondroitin;

         Enzyme Number (IUBMB): EC 2.8.2.51 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001537N-acetylgalactosamine 4-O-sulfotransferase activity IDA11056388
    GO:0008146sulfotransferase activity ----
    GO:0047756chondroitin 4-sulfotransferase activity IDA11056388
    GO:0050659N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IEA--
         
    CHST11 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chst11):
     craniofacial  growth/size/body  limbs/digits/tail  mortality/aging  respiratory system 
     skeleton 

    CHST11 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHST11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHST11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST11

    miRNA
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    miRTarBase miRNAs that target CHST11:
    hsa-mir-186-5p (MIRT021157), hsa-mir-1 (MIRT002789), hsa-mir-98-5p (MIRT027800)

    Block miRNA regulation of human, mouse, rat CHST11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST11 (see all 82):
    hsa-miR-26a-2* hsa-miR-4254 hsa-miR-607 hsa-miR-519a hsa-miR-1273d hsa-miR-509-3-5p hsa-miR-130b hsa-miR-3690
    SwitchGear 3'UTR luciferase reporter plasmidCHST11 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CHST11
    Predesigned siRNA for gene silencing in human, mouse, rat CHST11

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CHST11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CHST11 (NM_018413)
    Sino Biological Human cDNA Clone for CHST11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST11

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHSTB_HUMAN, Q9NPF2: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytoskeleton1
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane NAS11056388

    CHST11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHST11 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.00
    Chondroitin sulfate biosynthesis0.41
    3Biological oxidations
    metapathway biotransformation0.42
    4Metabolism
    Metabolism0.38
    5Spinal Cord Injury
    Spinal Cord Injury

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for CHST11
        Spinal Cord Injury
    Endochondral Ossification
    chondroitin sulfate biosynthesis (late stages)
    metapathway biotransformation
    chondroitin sulfate biosynthesis


    1 Reactome Pathway for CHST11
        Chondroitin sulfate biosynthesis


    1 Kegg Pathway  (Kegg details for CHST11):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate


    CHST11 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CHST11: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CHST11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for CHST11 (ENSP000003057254) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCANENSP000003312104STRING: ENSP00000331210
    BGNENSP000003273364STRING: ENSP00000327336
    BPNT1ENSP000003188524STRING: ENSP00000318852
    CHPFENSP000002437764STRING: ENSP00000243776
    CHST15ENSP000003339474STRING: ENSP00000333947
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002063chondrocyte development IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007585respiratory gaseous exchange IEA--
    GO:0009791post-embryonic development IEA--
    GO:0016051carbohydrate biosynthetic process IEA--

    CHST11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHST11 (CHSTB)

    5 HMDB Compounds for CHST11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    Chondroitin 4-sulfateChondroitin 4'-sulfate (see all 2)----
    DermatanChondroitin sulfate B (see all 13)24967-94-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    7 Novoseek inferred chemical compound relationships for CHST11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 92.4 52 1751554 (4), 11056388 (3), 16079159 (3), 10722746 (2) (see all 11)
    dermatan sulfate 76.7 2 12847091 (1)
    chondroitin sulfate 76.5 6 12847091 (1), 19915053 (1), 17597120 (1), 16079159 (1)
    3-phosphoadenosine 5'-phosphosulfate 71.9 4 11056388 (1), 10722746 (1)
    sulfate 70.3 8 11056388 (1), 10722746 (1), 16079159 (1)
    heparan sulfate 45.5 2 17113869 (1)
    polysaccharide 34.2 1 17113869 (1)



    CHST11 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHST11 gene (2 alternative transcripts): 
    NM_001173982.1  NM_018413.5  

    Unigene Cluster for CHST11:

    Carbohydrate (chondroitin 4) sulfotransferase 11
    Hs.17569  [show with all ESTs]
    Unigene Representative Sequence: NM_018413
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550711 ENST00000547956 ENST00000549260(uc001tky.3) ENST00000303694(uc001tkz.3)
    ENST00000546689 ENST00000549016
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CHST11 (see all 82):
    hsa-miR-26a-2* hsa-miR-4254 hsa-miR-607 hsa-miR-519a hsa-miR-1273d hsa-miR-509-3-5p hsa-miR-130b hsa-miR-3690
    SwitchGear 3'UTR luciferase reporter plasmidCHST11 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat CHST11
      QuantiFast Probe-based Assays in human, mouse, rat CHST11

    Additional mRNA sequence: 

    AB042326.1 AF131762.1 AF239820.1 AJ269537.2 AJ289134.1 AK123676.1 AK290923.1 AK313217.1 
    AL833176.1 AY533204.1 AY533205.1 BC013315.1 BC030271.1 BC061524.1 

    5 DOTS entries:

    DT.97765459  DT.100784578  DT.100784575  DT.121137744  DT.91649628 

    Selected AceView cDNA sequences (see all 154):

    AA634815 AF239820 AB042326 CD673275 CA309228 CD367266 BU174298 AF131762 
    BQ677890 BM763953 AW961343 AJ269537 BU838915 CR608680 AW028754 BQ006916 
    AA318376 CD676264 BC061524 AA305693 CA432716 AJ289134 BQ684300 AA465726 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CHST11    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
    SP1:              -           -         
    SP2:                          -         
    SP3:              -                     
    SP4:                                    


    ECgene alternative splicing isoforms for CHST11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHST11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHST11 Expression
    About this image


    CHST11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
    CHST11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHST11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.17569

    UniProtKB/Swiss-Prot: CHSTB_HUMAN, Q9NPF2
    Tissue specificity: Widely expressed. Highly expressed in spleen, thymus, bone marrow, peripheral blood
    leukocytes, lymph node, heart, brain, lung and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including CHST11: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CHST11
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST11
    QuantiTect SYBR Green Assays in human, mouse, rat CHST11
    QuantiFast Probe-based Assays in human, mouse, rat CHST11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHST11 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst111 , 5 carbohydrate sulfotransferase 111, 5 91.1(n)1
    96.87(a)1
      10 (40.66 cM)5
    582501  NM_021439.21  NP_067414.21 
     829854985 
    chicken
    (Gallus gallus)
    Aves CHST111 carbohydrate (chondroitin 4) sulfotransferase 11 84.94(n)
    93.75(a)
      418081  XM_004937826.1  XP_004937883.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHST116
    carbohydrate (chondroitin 4) sulfotransferase 11
    94(a)
    1 ↔ 1
    5(18382200-18612086)
    African clawed frog
    (Xenopus laevis)
    Amphibia chst11-prov2 carbohydrate sulfotransferase 11 72.65(n)    BC056117.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chst111 carbohydrate (chondroitin 4) sulfotransferase 11 75.57(n)
    78.69(a)
      404232  NM_212824.2  NP_997989.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG317431 CG31743 51.43(n)
    38.93(a)
      326156  NM_135976.2  NP_609820.1 


    ENSEMBL Gene Tree for CHST11 (if available)
    TreeFam Gene Tree for CHST11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHST11 gene
    CHST122  CHST132  CHST92  CHST102  CHST82  CHST142  
    6 SIMAP similar genes for CHST11 using alignment to 4 protein entries:     CHSTB_HUMAN (see all proteins):
    CHST13    CHST9    CHST8    CHST12    CHST10    CHST14

    CHST11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHST11 (see all 6407)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011407771,2
    Cuntested1104991503(+) CCAACA/GAGGCA 4 K E mis10--------
    rs784400191,2
    C--101910351(+) TTCTTT/CTTTTT 2 -- int12Minor allele frequency- C:0.25WA 4
    rs1118920861,2
    C--101928213(+) TATATA/TTATTT 2 -- int10--------
    rs1128065941,2
    C--101934374(+) TTGCAT/-TTTTT 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs710697591,2
    C--101934880(-) TTTGC-/CG/G  
            
    GGGGG
    2 -- int11NA 2
    rs113335861,2
    C--101934881(+) CCCCCG/-CAAAA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs768863351,2
    C--101934881(+) CCCCCC/GCAAAA 2 -- int10--------
    rs58006231,2
    C--101951940(+) CAGGT-/ACCTGG 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs339830861,2
    C--101951942(+) AGGTC-/ACTGGG 2 -- int10--------
    rs123709441,2
    C--101965651(+) ACTGGG/TGGGGG 2 -- int1 trp31Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for CHST11 (104849073 - 105099073 bp, first 250kb of CHST11)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CHST11 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746317CNV Deletion23290073
    esv2661506CNV Deletion23128226
    esv2746318CNV Deletion23290073
    esv26567CNV Loss19812545
    nsv899497CNV Loss21882294
    esv25429CNV Loss19812545
    nsv832502CNV Loss17160897
    nsv868CNV Loss18451855
    nsv515742CNV Loss19592680
    nsv899496CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHST11
    DNA2.0 Custom Variant and Variant Library Synthesis for CHST11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610128    OMIM disorders: --

    UniProtKB/Swiss-Prot: CHSTB_HUMAN, Q9NPF2
  • Note=A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias.
    Translocation t(12;14)(q23;q32) with IgH

  • 19 diseases for CHST11:    
    About MalaCards
    chronic lymphocytic leukemia    b-cell chronic lymphocytic leukemia    costello syndrome    cannabis dependence
    cutaneous lupus erythematosus    morquio syndrome b    sly syndrome    mucopolysaccharidoses
    leukemia    spinal cord injury    malaria    labyrinthitis
    lupus erythematosus    obesity    prostate cancer    prostatitis
    breast cancer    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for CHST11:
    Cutaneous lupus erythematosus

    CHST11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHST11
    Human Genome Epidemiology (HuGE) Navigator: CHST11 (5 documents)

    Export disorders for CHST11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHST11 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with CHST11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of two distinct human chondroitin 4- O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. (PubMed id 10781601)1, 2, 3 Hiraoka N.... Fukuda M. (J. Biol. Chem. 2000)
    2. Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. (PubMed id 11056388)1, 2, 9 Okuda T.... Habuchi O. (J. Biochem. 2000)
    3. Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32). (PubMed id 15273723)1, 2, 9 Schmidt H.H.... Chaganti R.S.K. (Oncogene 2004)
    4. Specificities of three distinct human chondroitin/dermatan N- acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor. Implication of differential roles in dermatan sulfate biosynthesis. (PubMed id 12847091)1, 2, 9 Mikami T.... Sugahara K. (J. Biol. Chem. 2003)
    5. A genome-wide association study of DSM-IV cannabis dependence. (PubMed id 21668797)1, 4 Agrawal A....Bierut L.J. (Addict Biol 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    8. Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria. (PubMed id 20580388)1, 4 Valente B....Silveira H. (Trans. R. Soc. Trop. Med. Hyg. 2010)
    9. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    10. N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1. (PubMed id 15628971)1, 2 Yusa A.... Habuchi O. (Biochem. J. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50515 HGNC: 17422 AceView: CHST11 Ensembl:ENSG00000171310 euGenes: HUgn50515
    ECgene: CHST11 Kegg: 50515 H-InvDB: CHST11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CHST11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHST11 gene:
    Search GeneIP for patents involving CHST11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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