Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHST11 Gene

Aliases for CHST11 Gene

  • Carbohydrate (Chondroitin 4) Sulfotransferase 11 2 3
  • Chondroitin 4-O-Sulfotransferase 1 3 4
  • EC 2.8.2.5 4 64
  • C4ST-1 3 4
  • C4S-1 3 4
  • C4ST1 3 4
  • Carbohydrate Sulfotransferase 11 3
  • Chondroitin 4-Sulfotransferase 1 4
  • IgH/CHST11 Fusion 3
  • HSA269537 3
  • C4ST 3

External Ids for CHST11 Gene

Summaries for CHST11 Gene

Entrez Gene Summary for CHST11 Gene

  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST11 Gene

CHST11 (Carbohydrate (Chondroitin 4) Sulfotransferase 11) is a Protein Coding gene. Diseases associated with CHST11 include chronic lymphocytic leukemia and cannabis dependence. Among its related pathways are Disease and Endochondral Ossification. GO annotations related to this gene include N-acetylgalactosamine 4-O-sulfotransferase activity and N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity. An important paralog of this gene is CHST13.

UniProtKB/Swiss-Prot for CHST11 Gene

  • Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor

Gene Wiki entry for CHST11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST11 Gene

Genomics for CHST11 Gene

Genomic Location for CHST11 Gene

Start:
104,455,295 bp from pter
End:
104,762,014 bp from pter
Size:
306,720 bases
Orientation:
Plus strand

Genomic View for CHST11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHST11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST11 Gene

Regulatory Elements for CHST11 Gene

Proteins for CHST11 Gene

  • Protein details for CHST11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPF2-CHSTB_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 11
    Protein Accession:
    Q9NPF2
    Secondary Accessions:
    • A8K4F8
    • Q9NXY6
    • Q9NY36

    Protein attributes for CHST11 Gene

    Size:
    352 amino acids
    Molecular mass:
    41555 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CHST11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHST11 Gene

Proteomics data for CHST11 Gene at MOPED

Post-translational modifications for CHST11 Gene

  • N-glycosylated; required for activity and stability.
  • Glycosylation at Asn205, Asn223, Asn321, and Asn342

Other Protein References for CHST11 Gene

Domains for CHST11 Gene

Gene Families for CHST11 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for CHST11 Gene

UniProtKB/Swiss-Prot:

CHSTB_HUMAN
Family:
  • Belongs to the sulfotransferase 2 family.:
    • Q9NPF2
genes like me logo Genes that share domains with CHST11: view

Function for CHST11 Gene

Molecular function for CHST11 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.5 uM for PAPS {ECO:0000269 PubMed:15628971}; KM=2.1 mM for chondroitin {ECO:0000269 PubMed:15628971};
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + chondroitin = adenosine 3,5-bisphosphate + chondroitin 4-sulfate.
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor

Enzyme Numbers (IUBMB) for CHST11 Gene

Gene Ontology (GO) - Molecular Function for CHST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity IDA 11056388
GO:0008146 sulfotransferase activity --
GO:0047756 chondroitin 4-sulfotransferase activity IDA 11056388
GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with CHST11: view
genes like me logo Genes that share phenotypes with CHST11: view

miRNA for CHST11 Gene

miRTarBase miRNAs that target CHST11

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CHST11 Gene

Localization for CHST11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST11 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST11 Gene COMPARTMENTS Subcellular localization image for CHST11 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane NAS 11056388
genes like me logo Genes that share ontologies with CHST11: view

Pathways for CHST11 Gene

genes like me logo Genes that share pathways with CHST11: view

Interacting Proteins for CHST11 Gene

Gene Ontology (GO) - Biological Process for CHST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002063 chondrocyte development IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007585 respiratory gaseous exchange IEA --
GO:0009791 post-embryonic development IEA --
GO:0016051 carbohydrate biosynthetic process IEA --
genes like me logo Genes that share ontologies with CHST11: view

Compounds for CHST11 Gene

(5) HMDB Compounds for CHST11 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Chondroitin
  • Chondroitin-D-glucuronate
9007-27-6
Chondroitin 4-sulfate
  • Chondroitin 4'-sulfate
Not Available
Dermatan
  • Chondroitin sulfate B
24967-94-0
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(7) Novoseek inferred chemical compound relationships for CHST11 Gene

Compound -log(P) Hits PubMed IDs
chondroitin 92.4 19
dermatan sulfate 76.7 1
chondroitin sulfate 76.5 4
3-phosphoadenosine 5-phosphosulfate 71.9 2
sulfate 70.3 3
genes like me logo Genes that share compounds with CHST11: view

Transcripts for CHST11 Gene

Unigene Clusters for CHST11 Gene

Carbohydrate (chondroitin 4) sulfotransferase 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHST11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for CHST11 Gene

GeneLoc Exon Structure for
CHST11
ECgene alternative splicing isoforms for
CHST11

Expression for CHST11 Gene

mRNA expression in normal human tissues for CHST11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST11 Gene

This gene is overexpressed in Whole Blood (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHST11 Gene

SOURCE GeneReport for Unigene cluster for CHST11 Gene Hs.17569

mRNA Expression by UniProt/SwissProt for CHST11 Gene

Q9NPF2-CHSTB_HUMAN
Tissue specificity: Widely expressed. Highly expressed in spleen, thymus, bone marrow, peripheral blood leukocytes, lymph node, heart, brain, lung and placenta.
genes like me logo Genes that share expressions with CHST11: view

Orthologs for CHST11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST11 36
  • 99.9 (n)
  • 99.71 (a)
CHST11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHST11 36
  • 92.52 (n)
  • 99.15 (a)
CHST11 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHST11 36
  • 91.48 (n)
  • 96.87 (a)
CHST11 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chst11 36
  • 91.1 (n)
  • 96.87 (a)
Chst11 16
Chst11 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHST11 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHST11 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chst11 36
  • 91.38 (n)
  • 96.87 (a)
chicken
(Gallus gallus)
Aves CHST11 36
  • 84.94 (n)
  • 93.75 (a)
CHST11 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST11 37
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia chst11-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia chst11 36
  • 78.87 (n)
  • 89.63 (a)
Str.15300 36
zebrafish
(Danio rerio)
Actinopterygii chst11 36
  • 75.57 (n)
  • 78.69 (a)
chst11 37
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004371 36
  • 52.12 (n)
  • 42.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31743 36
  • 51.43 (n)
  • 38.93 (a)
CG31743 37
  • 33 (a)
OneToMany
Species with no ortholog for CHST11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST11 Gene

ENSEMBL:
Gene Tree for CHST11 (if available)
TreeFam:
Gene Tree for CHST11 (if available)

Paralogs for CHST11 Gene

Paralogs for CHST11 Gene

Selected SIMAP similar genes for CHST11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHST11: view

Variants for CHST11 Gene

Sequence variations from dbSNP and Humsavar for CHST11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7847 -- 104,761,827(+) TTTTT(C/T)ACATA utr-variant-3-prime
rs10179 -- 104,761,820(+) ATTTT(C/T)TTTTT utr-variant-3-prime
rs167490 -- 104,701,434(-) ACCTA(C/T)GGTCA intron-variant
rs167510 -- 104,581,431(-) ATTTT(C/T)CTCAA intron-variant
rs182587 -- 104,734,317(-) GCCAA(C/T)CATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST11 Gene

Variant ID Type Subtype PubMed ID
nsv832502 CNV Loss 17160897
nsv832504 CNV Gain+Loss 17160897
nsv868 CNV Loss 18451855
esv2661506 CNV Deletion 23128226
esv26567 CNV Loss 19812545
nsv899495 CNV Gain 21882294
esv2746317 CNV Deletion 23290073
esv2746318 CNV Deletion 23290073
nsv515742 CNV Loss 19592680
esv25429 CNV Loss 19812545
nsv899496 CNV Gain 21882294
nsv899497 CNV Loss 21882294

Relevant External Links for CHST11 Gene

HapMap Linkage Disequilibrium report
CHST11

Disorders for CHST11 Gene

UniProtKB/Swiss-Prot

CHSTB_HUMAN
  • Note=A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias. Translocation t(12;14)(q23;q32) with IgH. {ECO:0000269 PubMed:15273723}.

(1) University of Copenhagen DISEASES for CHST11 Gene

Relevant External Links for CHST11

Genetic Association Database (GAD)
CHST11
Human Genome Epidemiology (HuGE) Navigator
CHST11
genes like me logo Genes that share disorders with CHST11: view

Publications for CHST11 Gene

  1. Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. (PMID: 11056388) Okuda T. … Habuchi O. (J. Biochem. 2000) 3 4 23
  2. Specificities of three distinct human chondroitin/dermatan N- acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor. Implication of differential roles in dermatan sulfate biosynthesis. (PMID: 12847091) Mikami T. … Sugahara K. (J. Biol. Chem. 2003) 3 4 23
  3. Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32). (PMID: 15273723) Schmidt H.H. … Chaganti R.S.K. (Oncogene 2004) 3 4 23
  4. Molecular cloning and expression of two distinct human chondroitin 4- O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. (PMID: 10781601) Hiraoka N. … Fukuda M. (J. Biol. Chem. 2000) 2 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CHST11 Gene

Sources for CHST11 Gene

Back to Top

Content