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Aliases for CHST10 Gene

Aliases for CHST10 Gene

  • Carbohydrate Sulfotransferase 10 2 3 5
  • HNK-1 Sulfotransferase 3 4
  • HuHNK-1ST 3 4
  • HNK-1ST 3 4
  • HNK1ST 3 4
  • EC 2.8.2.- 4
  • EC 2.8.2 63

External Ids for CHST10 Gene

Previous GeneCards Identifiers for CHST10 Gene

  • GC02M099461
  • GC02M100612
  • GC02M100629
  • GC02M101008
  • GC02M094773

Summaries for CHST10 Gene

Entrez Gene Summary for CHST10 Gene

  • This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]

GeneCards Summary for CHST10 Gene

CHST10 (Carbohydrate Sulfotransferase 10) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Articular Cartilage Extracellular Matrix Pathway. GO annotations related to this gene include sulfotransferase activity and HNK-1 sulfotransferase activity. An important paralog of this gene is CHST9.

UniProtKB/Swiss-Prot for CHST10 Gene

  • Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.

Gene Wiki entry for CHST10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST10 Gene

Genomics for CHST10 Gene

Regulatory Elements for CHST10 Gene

Promoters for CHST10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHST10 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHST10 Gene

Chromosome:
2
Start:
100,391,860 bp from pter
End:
100,417,668 bp from pter
Size:
25,809 bases
Orientation:
Minus strand

Genomic View for CHST10 Gene

Genes around CHST10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHST10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHST10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST10 Gene

Proteins for CHST10 Gene

  • Protein details for CHST10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43529-CHSTA_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 10
    Protein Accession:
    O43529
    Secondary Accessions:
    • Q53T18

    Protein attributes for CHST10 Gene

    Size:
    356 amino acids
    Molecular mass:
    42207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHST10 Gene

Proteomics data for CHST10 Gene at MOPED

Post-translational modifications for CHST10 Gene

  • Glycosylation at Thr 66, Asn 99, Asn 228, and Asn 316
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for CHST10 Gene

Gene Families for CHST10 Gene

Protein Domains for CHST10 Gene

Suggested Antigen Peptide Sequences for CHST10 Gene

Graphical View of Domain Structure for InterPro Entry

O43529

UniProtKB/Swiss-Prot:

CHSTA_HUMAN :
  • Belongs to the sulfotransferase 2 family.
Family:
  • Belongs to the sulfotransferase 2 family.
genes like me logo Genes that share domains with CHST10: view

Function for CHST10 Gene

Molecular function for CHST10 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.

Enzyme Numbers (IUBMB) for CHST10 Gene

genes like me logo Genes that share phenotypes with CHST10: view

Animal Models for CHST10 Gene

MGI Knock Outs for CHST10:

Animal Model Products

miRNA for CHST10 Gene

miRTarBase miRNAs that target CHST10

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHST10 Gene

Localization for CHST10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST10 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST10 Gene COMPARTMENTS Subcellular localization image for CHST10 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
cytosol 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHST10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CHST10: view

Pathways & Interactions for CHST10 Gene

genes like me logo Genes that share pathways with CHST10: view

Interacting Proteins for CHST10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264249%0d%0a9606.ENSP00000431512%0d%0a
Selected Interacting proteins: O43529-CHSTA_HUMAN ENSP00000264249 for CHST10 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CHST10 Gene

None

No data available for SIGNOR curated interactions for CHST10 Gene

Drugs & Compounds for CHST10 Gene

(1) Drugs for CHST10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for CHST10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CHST10: view

Transcripts for CHST10 Gene

Unigene Clusters for CHST10 Gene

Carbohydrate sulfotransferase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHST10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - -
SP13:

ExUns: 12d ^ 13a · 13b ^ 14a · 14b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CHST10 Gene

GeneLoc Exon Structure for
CHST10
ECgene alternative splicing isoforms for
CHST10

Expression for CHST10 Gene

mRNA expression in normal human tissues for CHST10 Gene

Protein differential expression in normal tissues from HIPED for CHST10 Gene

This gene is overexpressed in Vitreous humor (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHST10 Gene



SOURCE GeneReport for Unigene cluster for CHST10 Gene Hs.516370

mRNA Expression by UniProt/SwissProt for CHST10 Gene

O43529-CHSTA_HUMAN
Tissue specificity: In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at higher level in the frontal lobe.
genes like me logo Genes that share expression patterns with CHST10: view

Protein tissue co-expression partners for CHST10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHST10 Gene

Orthologs for CHST10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHST10 35
  • 86.04 (n)
  • 91.45 (a)
CHST10 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHST10 35
  • 89.84 (n)
  • 94.3 (a)
CHST10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chst10 35
  • 86.61 (n)
  • 91.01 (a)
Chst10 16
Chst10 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHST10 35
  • 99.44 (n)
  • 99.16 (a)
CHST10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chst10 35
  • 87.08 (n)
  • 90.17 (a)
oppossum
(Monodelphis domestica)
Mammalia CHST10 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves CHST10 35
  • 78.28 (n)
  • 85.96 (a)
CHST10 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST10 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chst10 35
  • 71.31 (n)
  • 76.42 (a)
Str.16232 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8239 35
zebrafish
(Danio rerio)
Actinopterygii chst10 35
  • 65.15 (n)
  • 67.05 (a)
Dr.11834 35
chst10 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13937 36
  • 17 (a)
ManyToMany
CG14024 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
Species with no ortholog for CHST10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST10 Gene

ENSEMBL:
Gene Tree for CHST10 (if available)
TreeFam:
Gene Tree for CHST10 (if available)

Paralogs for CHST10 Gene

Paralogs for CHST10 Gene

(4) SIMAP similar genes for CHST10 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CHST10: view

Variants for CHST10 Gene

Sequence variations from dbSNP and Humsavar for CHST10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3748932 - 100,393,544(-) TTGGG(A/G)ACCAC reference, missense
rs35177621 - 100,406,618(-) TCATG(G/T)TGGCT reference, missense
rs1057055 -- 100,392,914(-) CCGTT(C/T)CCTTC utr-variant-3-prime
rs1057056 -- 100,392,620(-) CAGGG(A/G)TCCAT utr-variant-3-prime
rs1057063 -- 100,392,105(-) TCCTG(G/T)CAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CHST10 Gene

Variant ID Type Subtype PubMed ID
nsv874701 CNV Gain 21882294
nsv829583 CNV Gain 20364138

Variation tolerance for CHST10 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.49; 85.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHST10 Gene

HapMap Linkage Disequilibrium report
CHST10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST10 Gene

Disorders for CHST10 Gene

Relevant External Links for CHST10

Genetic Association Database (GAD)
CHST10
Human Genome Epidemiology (HuGE) Navigator
CHST10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHST10

No disorders were found for CHST10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHST10 Gene

Publications for CHST10 Gene

  1. Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis. (PMID: 10464296) Ong E. … Fukuda M. (J. Biol. Chem. 1999) 3 4 23 67
  2. Molecular cloning and characterization of chondroitin-4-O- sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases. (PMID: 12080076) Kang H.-G. … Schachner M. (J. Biol. Chem. 2002) 2 3 23
  3. Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. (PMID: 19470764) Zhao X. … Spanjaard R.A. (Cancer Res. 2009) 3 23
  4. Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids. (PMID: 9478973) Ong E. … Fukuda M. (J. Biol. Chem. 1998) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CHST10 Gene

Sources for CHST10 Gene

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