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Set Analyses:

VarElect

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CHST10 Gene

protein-coding GIFtS: 58
GCID: GC02M101008

Carbohydrate Sulfotransferase 10

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Carbohydrate Sulfotransferase 10¹ ²		huHNK-1ST²
HNK1ST² ³ ⁵		EC 2.8.2.-³
HNK-1ST² ³		HuHNK-1ST³
HNK-1 Sulfotransferase² ³		EC 2.8.2⁸

External Ids:	HGNC: 19650¹	Entrez Gene: 9486²	Ensembl: ENSG00000115526⁷	OMIM: 606376⁵	UniProtKB: O43529³

Export aliases for CHST10 gene to outside databases

Previous GC identifers: GC02M099461 GC02M100612 GC02M100629 GC02M100466 GC02M094773

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHST10 Gene:

This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein-

and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human

natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic

plasticity.(provided by RefSeq, Feb 2011)

GeneCards Summary for CHST10 Gene:

CHST10 (carbohydrate sulfotransferase 10) is a protein-coding gene. Diseases associated with CHST10 include schizophrenia, and melanoma. GO annotations related to this gene include HNK-1 sulfotransferase activity and sulfotransferase activity. An important paralog of this gene is CHST12.

UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529

Function: Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and

lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated

glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell

interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved

in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis

Gene Wiki entry for CHST10 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000002.12 NC_018913.2 NT_005403.18

Regulatory elements:

Regulatory transcription factor binding sites in the CHST10 gene promoter:
TBP AML1a MEF-2 CUTL1 Cdc5 HNF-3beta MEF-2A RORalpha1 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHST10 promoter sequence

Search Chromatin IP Primers for CHST10

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHST10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2

CHST10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST10 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M101008: view genomic region (about GC identifiers)

Start:	101,008,322 bp from pter	End:	101,034,130 bp from pter
Size:	25,809 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529 (See protein sequence)

Recommended Name: Carbohydrate sulfotransferase 10

Size: 356 amino acids; 42207 Da

Secondary accessions: Q53T18

Explore the universe of human proteins at neXtProt for CHST10: NX_O43529

Explore proteomics data for CHST10 at MOPED

Post-translational modifications:

Glycosylation² at Thr66, Asn99, Asn228, Asn316

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for CHST10 (O43529) (see all 9)

YNRTKVE

GHHETLE

LCAPCEI

DFKLFGY

See CHST10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004845.1

ENSEMBL proteins:

ENSP00000264249 ENSP00000387309 ENSP00000387121 ENSP00000405922 ENSP00000387977

ENSP00000407525 ENSP00000416831 ENSP00000395643 ENSP00000438869

CHST10 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CHST10 (Carbohydrate Sulfotransferase 10/CHST10)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for CHST10 OriGene Protein Over-expression Lysate for CHST10 OriGene MassSpec for CHST10 OriGene Custom Protein Services for CHST10
	GenScript Custom Purified and Recombinant Proteins Services for CHST10
	Novus Biologicals CHST10 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for CHST10

CHST10 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for CHST10 OriGene Custom Antibody Services for CHST10
	Novus Biologicals CHST10 Antibodies
	Abcam antibodies for CHST10
	Cloud-Clone Corp. Antibodies for CHST10
	Search ThermoFisher Antibodies for CHST10
	LSBio Antibodies in human, mouse, rat for CHST10

CHST10 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CHST10
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CHST10
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for CHST10 Cloud-Clone Corp. CLIAs for CHST10

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

SULTM: Sulfotransferases, membrane-bound

2 InterPro protein domains:

IPR005331 Sulfotransferase

IPR018011 Carb_sulfotransferase-rel

Graphical View of Domain Structure for InterPro Entry O43529

ProtoNet protein and cluster: O43529

UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529

Similarity: Belongs to the sulfotransferase 2 family

CHST10 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CHSTA_HUMAN, O43529

Function: Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and

lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated

glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell

interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved

in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis

Enzyme Numbers (IUBMB): EC 2.8.2.-¹ EC 2.8.2²

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008146	sulfotransferase activity	TAS	9478973
GO:0016232	HNK-1 sulfotransferase activity	IEA	--

CHST10 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CHST10:

Increased cell number in G1, a

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Chst10):

behavior/neurological

homeostasis/metabolism

nervous system

reproductive system

CHST10 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for CHST10: Chst10^tm1Msch Chst10^tm1Mifu

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHST10

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHST10

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST10

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST10

miRNA Products:		Block miRNA regulation of human, mouse, rat CHST10 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CHST10 (see all 12):
		hsa-miR-137 hsa-miR-130a* hsa-miR-1271 hsa-miR-23c hsa-miR-4299 hsa-miR-182 hsa-miR-23b hsa-miR-143

		SwitchGear 3'UTR luciferase reporter plasmid: CHST10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CHST10
		Predesigned siRNA for gene silencing in human, mouse, rat CHST10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CHST10

Clone Products:		OriGene clones in human, mouse for CHST10 (see all 8) OriGene ORF clones in mouse, rat for CHST10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHST10 (NM_004854)
		Sino Biological Human cDNA Clone for CHST10
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CHST10
		Browse ESI BIO Cell Lines and PureStem Progenitors for CHST10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST10

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CHSTA_HUMAN, O43529: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
golgi apparatus	5
extracellular	3
endoplasmic reticulum	1
peroxisome	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005794	Golgi apparatus	TAS	9478973
GO:0016020	membrane	TAS	9478973
GO:0016021	integral component of membrane	IEA	--

CHST10 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CHST10 About

See pathways by source

SuperPath

Contained pathways About

Biological oxidations

metapathway biotransformation

0.42

Other types of O-glycan biosynthesis

Other types of O-glycan biosynthesis

Articular Cartilage Extracellular Matrix

Articular Cartilage Extracellular Matrix

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for CHST10

Articular Cartilage Extracellular Matrix

1 BioSystems Pathway for CHST10

metapathway biotransformation

1 Kegg Pathway (Kegg details for CHST10):

Other types of O-glycan biosynthesis

CHST10 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including CHST10:

Cell Surface Markers in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for CHST10

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for CHST10 (O43529³ ENSP00000264249⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EEF1G	P26641³	I2D: score=1
--	ENSP00000332698⁴	STRING: ENSP00000332698

About this table

Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	9478973
GO:0007612	learning	IEA	--
GO:0007616	long-term memory	IEA	--
GO:0016051	carbohydrate biosynthetic process	IEA	--

CHST10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CHST10 (CHSTA)

3 Novoseek inferred chemical compound relationships for CHST10 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chondroitin	81.1	2	11445554 (1)
sulfate	70.9	4	9478973 (1), 19533738 (1), 10988300 (1)
glucuronic acid	63.8	1	19533738 (1)

CHST10 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CHST10 gene:

NM_004854.4

Unigene Cluster for CHST10:

Carbohydrate sulfotransferase 10

Hs.516370 [show with all ESTs]

Unigene Representative Sequence: AF033827

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000264249(uc002tam.3) ENST00000409701 ENST00000484382 ENST00000409046

ENST00000420858 ENST00000448989 ENST00000421474 ENST00000418201 ENST00000435960

ENST00000485085 ENST00000487860 ENST00000466583 ENST00000542617

miRNA Products:		Block miRNA regulation of human, mouse, rat CHST10 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CHST10 (see all 12):
		hsa-miR-137 hsa-miR-130a* hsa-miR-1271 hsa-miR-23c hsa-miR-4299 hsa-miR-182 hsa-miR-23b hsa-miR-143

		SwitchGear 3'UTR luciferase reporter plasmid: CHST10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CHST10
		Predesigned siRNA for gene silencing in human, mouse, rat CHST10

Clone Products:		OriGene clones in human, mouse for CHST10 (see all 8) OriGene ORF clones in mouse, rat for CHST10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHST10 (NM_004854)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST10

Primer Products:		OriGene qPCR primer pairs and template standards for CHST10 OriGene qSTAR qPCR primer pairs in human, mouse for CHST10
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CHST10
		QuantiTect SYBR Green Assays in human, mouse, rat CHST10
		QuantiFast Probe-based Assays in human, mouse, rat CHST10

Additional mRNA sequence:

AF033827.1 AF070594.1 AK297267.1 AK313241.1 BC010441.1

8 DOTS entries:

DT.115676 DT.120998747 DT.309150 DT.95160052 DT.100761173 DT.100776489 DT.120998751 DT.431181

Selected AceView cDNA sequences (see all 154):

AF070594 BQ029541 Z40274 AI362035 BE046941 AW247310 AW304044 BF941926

BM686627 BM703147 AI572361 BQ018982 BM664647 BM453987 AW104630 BE856346

BG026467 BM013664 AU108004 AU125990 NM_004854 Z41355 AW135230 CA421420

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHST10 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	·
SP1:													-		-		-		-		-		-		-		-		-				-		-		-		-
SP2:													-		-		-		-		-		-		-		-		-						-
SP3:																	-		-		-		-		-		-		-				-		-		-		-
SP4:																													-				-		-		-		-
SP5:																																	-		-		-		-

ExUns:	12d	^	13a	·	13b	^	14a	·	14b
SP1:			-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CHST10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CHST10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGCCGCCGA

About this image

CHST10 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CHST10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.516370

UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529

Tissue specificity: In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney

and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart,

pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at

higher level in the frontal lobe

Pathway & Disease-focused RT² Profiler PCR Array including CHST10:

Cell Surface Markers in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CHST10 OriGene qSTAR qPCR primer pairs in human, mouse for CHST10
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CHST10
		QuantiTect SYBR Green Assays in human, mouse, rat CHST10
		QuantiFast Probe-based Assays in human, mouse, rat CHST10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CHST10 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Chst10^{1 , 5}	carbohydrate sulfotransferase 10^{1, 5}	86.61(n)¹ 91.01(a)¹		1 (17.24 cM)⁵ 98388¹ NM_145142.2¹ NP_660124.2¹ 38863877⁵
chicken (Gallus gallus)	Aves	CHST10¹	carbohydrate sulfotransferase 10	78.28(n) 85.96(a)		395206 NM_001030343.1 NP_001025514.1
lizard (Anolis carolinensis)	Reptilia	CHST10⁶	carbohydrate sulfotransferase 10	85(a)	1 ↔ 1	GL343456.1(625180-639748)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8239²	Xenopus laevis transcribed sequence with moderate similarity more	77.17(n)		48024128
zebrafish (Danio rerio)	Actinopterygii	Dr.11834²	Transcribed sequence with weak similarity to protein more	75.08(n)		CA471403.1
fruit fly (Drosophila melanogaster)	Insecta	CG14024⁶ CG13937⁶	--	18(a) 17(a)	many ↔ many many ↔ many	2L(5311311-5314885) 3L(1876551-1883041)

ENSEMBL Gene Tree for CHST10 (if available)
TreeFam Gene Tree for CHST10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CHST10 gene

CHST12² CHST13² CHST9² CHST11² CHST8² CHST14²

4 SIMAP similar genes for CHST10 using alignment to 8 protein entries: CHSTA_HUMAN (see all proteins):

CHST11 CHST9 CHST13 CHST8

CHST10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9808480^1,2	C,F,H	--	100663742(+)	`TGGTAG/ACAATC`	1	--	int¹		9		NS EA NA WA	1206
rs185794743^1,2		--	100663928(+)	`TAATCA/GATCAG`	1	--	int¹		0	--	--	--	--
rs116430461^1,2	F	--	100664045(+)	`CCTGCG/AGTCTG`	1	--	int¹		2		WA NA	238
rs6755285^1,2	C,F,A,H	--	100664059(+)	`ACCCTG/AAGCAG`	1	--	int¹		20		NS EA WA NA CSA	2213
rs145953730^1,2		--	100664103(+)	`GCCTGA/GGGCGC`	1	--	int¹		0	--	--	--	--
rs75528420^1,2	C	--	100664136(+)	`CAGAAA/CCGCAG`	1	--	int¹		0	--	--	--	--
rs142238043^1,2		--	100664200(+)	`AGGAAA/GCCATT`	1	--	ut3¹		0	--	--	--	--
rs190353119^1,2		--	100664223(+)	`AGAGGC/TCGCCT`	1	--	ut3¹		0	--	--	--	--
rs182231104^1,2		--	100664343(+)	`GACGGC/TATCTG`	1	--	ut3¹		0	--	--	--	--
rs1057064^1,2	C,F,A,H	--	100664392(-)	`CCTGGC/TAACAA`	1	--	ut3¹ ese³		10		MN NS EA WA NA	934

HapMap Linkage Disequilibrium report for CHST10 (101008322 - 101034130 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for CHST10: About this table

Variant ID	Type	Subtype	PubMed ID
nsv874701	CNV	Gain	21882294
nsv829583	CNV	Gain	20364138

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CHST10

DNA2.0 Custom Variant and Variant Library Synthesis for CHST10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606376 OMIM disorders: --

3 diseases for CHST10:
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schizophrenia melanoma neuronitis

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Genetic Association Database (GAD): CHST10
Human Genome Epidemiology (HuGE) Navigator: CHST10 (2 documents)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CHST10 gene, integrated from 10 sources (see all 32):
(articles sorted by number of sources associating them with CHST10)

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Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis. (PubMed id 10464296)^{1, 2, 9} Ong E....Fukuda M. (J. Biol. Chem. 1999)
Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids. (PubMed id 9478973)^{1, 2, 9} Ong E.... Fukuda M. (J. Biol. Chem. 1998)
Molecular cloning and characterization of chondroitin-4-O- sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases. (PubMed id 12080076)^{1, 3, 9} Kang H.-G.... Schachner M. (J. Biol. Chem. 2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. (PubMed id 19470764)^{1, 9} Zhao X....Spanjaard R.A. (Cancer Res. 2009)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (Sci Signal 2012)
Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate transfer regulates laminin-binding glycans on I+-dystroglycan. (PubMed id 22801424)¹ Nakagawa N....Oka S. (J. Biol. Chem. 2012)
Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)¹ Liu B....Wang L.S. (J. Proteome Res. 2012)
Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin. (PubMed id 22020094)¹ Nakagawa N....Oka S. (Biochem. Biophys. Res. Commun. 2011)
Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (Mol. Syst. Biol. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9486	HGNC: 19650	AceView: CHST10	Ensembl:ENSG00000115526	euGenes: HUgn9486
ECgene: CHST10	Kegg: 9486	H-InvDB: CHST10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CHST10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CHST10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CHST10 gene:
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CHST10 Gene

Carbohydrate Sulfotransferase 10

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Carbohydrate Sulfotransferase 10

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