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CHST10 Gene

protein-coding   GIFtS: 58
GCID: GC02M101008

Carbohydrate Sulfotransferase 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbohydrate Sulfotransferase 101 2     huHNK-1ST2
HNK1ST2 3 5     EC 2.8.2.-3
HNK-1ST2 3     HuHNK-1ST3
HNK-1 Sulfotransferase2 3     EC 2.8.28

External Ids:    HGNC: 196501   Entrez Gene: 94862   Ensembl: ENSG000001155267   OMIM: 6063765   UniProtKB: O435293   

Export aliases for CHST10 gene to outside databases

Previous GC identifers: GC02M099461 GC02M100612 GC02M100629 GC02M100466 GC02M094773


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHST10 Gene:
This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein-
and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human
natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic
plasticity.(provided by RefSeq, Feb 2011)

GeneCards Summary for CHST10 Gene:
CHST10 (carbohydrate sulfotransferase 10) is a protein-coding gene. Diseases associated with CHST10 include schizophrenia, and melanoma. GO annotations related to this gene include HNK-1 sulfotransferase activity and sulfotransferase activity. An important paralog of this gene is CHST12.

UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529
Function: Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and
lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated
glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell
interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved
in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis

Gene Wiki entry for CHST10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHST10 gene promoter:
         TBP   AML1a   MEF-2   CUTL1   Cdc5   HNF-3beta   MEF-2A   RORalpha1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST10 promoter sequence
   Search Chromatin IP Primers for CHST10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHST10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

CHST10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M101008:  view genomic region     (about GC identifiers)

Start:
101,008,322 bp from pter      End:
101,034,130 bp from pter
Size:
25,809 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 10  
Size: 356 amino acids; 42207 Da
Secondary accessions: Q53T18

Explore the universe of human proteins at neXtProt for CHST10: NX_O43529

Explore proteomics data for CHST10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr66, Asn99, Asn228, Asn316
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CHST10 (O43529) (see all 9)
     YNRTKVE  GHHETLE  LCAPCEI  DFKLFGY 


    See CHST10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004845.1  
    ENSEMBL proteins: 
     ENSP00000264249   ENSP00000387309   ENSP00000387121   ENSP00000405922   ENSP00000387977  
     ENSP00000407525   ENSP00000416831   ENSP00000395643   ENSP00000438869  

    CHST10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CHST10 (Carbohydrate Sulfotransferase 10/CHST10)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CHST10
    OriGene Protein Over-expression Lysate for CHST10
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    Novus Biologicals CHST10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHST10

    CHST10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CHST10
    Cloud-Clone Corp. Antibodies for CHST10
    Search ThermoFisher Antibodies for CHST10
    LSBio Antibodies in human, mouse, rat for CHST10

    CHST10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CHST10
    Cloud-Clone Corp. CLIAs for CHST10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR005331 Sulfotransferase
     IPR018011 Carb_sulfotransferase-rel

    Graphical View of Domain Structure for InterPro Entry O43529

    ProtoNet protein and cluster: O43529

    UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529
    Similarity: Belongs to the sulfotransferase 2 family


    CHST10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHSTA_HUMAN, O43529
    Function: Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and
    lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated
    glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell
    interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved
    in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis

         Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.22

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity TAS9478973
    GO:0016232HNK-1 sulfotransferase activity IEA--
         
    CHST10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHST10:
     Increased cell number in G1, a 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chst10):
     behavior/neurological  homeostasis/metabolism  nervous system  reproductive system 

    CHST10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CHST10: Chst10tm1Msch Chst10tm1Mifu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHST10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHST10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST10

    miRNA
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    Block miRNA regulation of human, mouse, rat CHST10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST10 (see all 12):
    hsa-miR-137 hsa-miR-130a* hsa-miR-1271 hsa-miR-23c hsa-miR-4299 hsa-miR-182 hsa-miR-23b hsa-miR-143
    SwitchGear 3'UTR luciferase reporter plasmidCHST10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHST10
    Predesigned siRNA for gene silencing in human, mouse, rat CHST10

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for CHST10 (see all 8)
    OriGene ORF clones in mouse, rat for CHST10
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    GenScript: all cDNA clones in your preferred vector: CHST10 (NM_004854)
    Sino Biological Human cDNA Clone for CHST10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST10

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CHST10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHSTA_HUMAN, O43529: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular3
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus TAS9478973
    GO:0016020membrane TAS9478973
    GO:0016021integral component of membrane IEA--

    CHST10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHST10 About    
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    metapathway biotransformation0.42
    2Other types of O-glycan biosynthesis
    Other types of O-glycan biosynthesis
    3Articular Cartilage Extracellular Matrix
    Articular Cartilage Extracellular Matrix

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CHST10
        Articular Cartilage Extracellular Matrix


    1 BioSystems Pathway for CHST10
        metapathway biotransformation



    1 Kegg Pathway  (Kegg details for CHST10):
        Other types of O-glycan biosynthesis


    CHST10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CHST10: 
              Cell Surface Markers in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CHST10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CHST10 (O435293 ENSP000002642494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1GP266413I2D: score=1 
    --ENSP000003326984STRING: ENSP00000332698
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS9478973
    GO:0007612learning IEA--
    GO:0007616long-term memory IEA--
    GO:0016051carbohydrate biosynthetic process IEA--

    CHST10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHST10 (CHSTA)

    3 Novoseek inferred chemical compound relationships for CHST10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 81.1 2 11445554 (1)
    sulfate 70.9 4 9478973 (1), 19533738 (1), 10988300 (1)
    glucuronic acid 63.8 1 19533738 (1)



    CHST10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHST10 gene: 
    NM_004854.4  

    Unigene Cluster for CHST10:

    Carbohydrate sulfotransferase 10
    Hs.516370  [show with all ESTs]
    Unigene Representative Sequence: AF033827
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264249(uc002tam.3) ENST00000409701 ENST00000484382 ENST00000409046
    ENST00000420858 ENST00000448989 ENST00000421474 ENST00000418201 ENST00000435960
    ENST00000485085 ENST00000487860 ENST00000466583 ENST00000542617
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHST10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST10 (see all 12):
    hsa-miR-137 hsa-miR-130a* hsa-miR-1271 hsa-miR-23c hsa-miR-4299 hsa-miR-182 hsa-miR-23b hsa-miR-143
    SwitchGear 3'UTR luciferase reporter plasmidCHST10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHST10
    Predesigned siRNA for gene silencing in human, mouse, rat CHST10
    Clone
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    OriGene clones in human, mouse for CHST10 (see all 8)
    OriGene ORF clones in mouse, rat for CHST10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHST10 (NM_004854)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHST10
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST10
      QuantiTect SYBR Green Assays in human, mouse, rat CHST10
      QuantiFast Probe-based Assays in human, mouse, rat CHST10

    Additional mRNA sequence: 

    AF033827.1 AF070594.1 AK297267.1 AK313241.1 BC010441.1 

    8 DOTS entries:

    DT.115676  DT.120998747  DT.309150  DT.95160052  DT.100761173  DT.100776489  DT.120998751  DT.431181 

    Selected AceView cDNA sequences (see all 154):

    AF070594 BQ029541 Z40274 AI362035 BE046941 AW247310 AW304044 BF941926 
    BM686627 BM703147 AI572361 BQ018982 BM664647 BM453987 AW104630 BE856346 
    BG026467 BM013664 AU108004 AU125990 NM_004854 Z41355 AW135230 CA421420 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHST10 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
    SP1:                                      -     -     -     -     -     -     -     -     -           -     -     -     -                                       
    SP2:                                      -     -     -     -     -     -     -     -     -                 -                                                   
    SP3:                                                  -     -     -     -     -     -     -           -     -     -     -                                       
    SP4:                                                                                      -           -     -     -     -                                       
    SP5:                                                                                                  -     -     -     -                                       

    ExUns: 12d ^ 13a · 13b ^ 14a · 14b
    SP1:        -                     
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CHST10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHST10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCGCCGA
    CHST10 Expression
    About this image

    CHST10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHST10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516370

    UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529
    Tissue specificity: In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney
    and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart,
    pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at
    higher level in the frontal lobe

        Pathway & Disease-focused RT2 Profiler PCR Array including CHST10: 
              Cell Surface Markers in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHST10
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST10
    QuantiTect SYBR Green Assays in human, mouse, rat CHST10
    QuantiFast Probe-based Assays in human, mouse, rat CHST10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHST10 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst101 , 5 carbohydrate sulfotransferase 101, 5 86.61(n)1
    91.01(a)1
      1 (17.24 cM)5
    983881  NM_145142.21  NP_660124.21 
     388638775 
    chicken
    (Gallus gallus)
    Aves CHST101 carbohydrate sulfotransferase 10 78.28(n)
    85.96(a)
      395206  NM_001030343.1  NP_001025514.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHST106
    carbohydrate sulfotransferase 10
    85(a)
    1 ↔ 1
    GL343456.1(625180-639748)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.82392 Xenopus laevis transcribed sequence with moderate similarity more 77.17(n)    48024128 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.118342 Transcribed sequence with weak similarity to protein more 75.08(n)    CA471403.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG140246
    CG139376
    --
    18(a)
    17(a)
    many ↔ many
    many ↔ many
    2L(5311311-5314885)
    3L(1876551-1883041)


    ENSEMBL Gene Tree for CHST10 (if available)
    TreeFam Gene Tree for CHST10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHST10 gene
    CHST122  CHST132  CHST92  CHST112  CHST82  CHST142  
    4 SIMAP similar genes for CHST10 using alignment to 8 protein entries:     CHSTA_HUMAN (see all proteins):
    CHST11    CHST9    CHST13    CHST8

    CHST10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHST10 (see all 665)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs98084801,2
    C,F,H--100663742(+) TGGTAG/ACAATC 1 -- int19Minor allele frequency- A:0.10NS EA NA WA 1206
    rs1857947431,2
    --100663928(+) TAATCA/GATCAG 1 -- int10--------
    rs1164304611,2
    F--100664045(+) CCTGCG/AGTCTG 1 -- int12Minor allele frequency- A:0.03WA NA 238
    rs67552851,2
    C,F,A,H--100664059(+) ACCCTG/AAGCAG 1 -- int120Minor allele frequency- A:0.18NS EA WA NA CSA 2213
    rs1459537301,2
    --100664103(+) GCCTGA/GGGCGC 1 -- int10--------
    rs755284201,2
    C--100664136(+) CAGAAA/CCGCAG 1 -- int10--------
    rs1422380431,2
    --100664200(+) AGGAAA/GCCATT 1 -- ut310--------
    rs1903531191,2
    --100664223(+) AGAGGC/TCGCCT 1 -- ut310--------
    rs1822311041,2
    --100664343(+) GACGGC/TATCTG 1 -- ut310--------
    rs10570641,2
    C,F,A,H--100664392(-) CCTGGC/TAACAA 1 -- ut31 ese310Minor allele frequency- T:0.14MN NS EA WA NA 934

    HapMap Linkage Disequilibrium report for CHST10 (101008322 - 101034130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CHST10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874701CNV Gain21882294
    nsv829583CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHST10
    DNA2.0 Custom Variant and Variant Library Synthesis for CHST10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606376    OMIM disorders: --

    3 diseases for CHST10:    
    About MalaCards
    schizophrenia    melanoma    neuronitis


    CHST10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHST10
    Human Genome Epidemiology (HuGE) Navigator: CHST10 (2 documents)

    Export disorders for CHST10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHST10 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CHST10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis. (PubMed id 10464296)1, 2, 9 Ong E....Fukuda M. (J. Biol. Chem. 1999)
    2. Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids. (PubMed id 9478973)1, 2, 9 Ong E.... Fukuda M. (J. Biol. Chem. 1998)
    3. Molecular cloning and characterization of chondroitin-4-O- sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases. (PubMed id 12080076)1, 3, 9 Kang H.-G.... Schachner M. (J. Biol. Chem. 2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. (PubMed id 19470764)1, 9 Zhao X....Spanjaard R.A. (Cancer Res. 2009)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate transfer regulates laminin-binding glycans on I+-dystroglycan. (PubMed id 22801424)1 Nakagawa N....Oka S. (J. Biol. Chem. 2012)
    8. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    9. Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin. (PubMed id 22020094)1 Nakagawa N....Oka S. (Biochem. Biophys. Res. Commun. 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9486 HGNC: 19650 AceView: CHST10 Ensembl:ENSG00000115526 euGenes: HUgn9486
    ECgene: CHST10 Kegg: 9486 H-InvDB: CHST10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CHST10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CHST10 gene:
    Search GeneIP for patents involving CHST10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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