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CHST10 Gene

protein-coding   GIFtS: 58
GCID: GC02M101008

Carbohydrate Sulfotransferase 10

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Aliases
for CHST10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbohydrate Sulfotransferase 101 2     huHNK-1ST2
HNK1ST2 3 5     EC 2.8.2.-3
HNK-1ST2 3     HuHNK-1ST3
HNK-1 Sulfotransferase2 3     EC 2.8.28

External Ids:    HGNC: 196501   Entrez Gene: 94862   Ensembl: ENSG000001155267   OMIM: 6063765   UniProtKB: O435293   

Export aliases for CHST10 gene to outside databases

Previous GC identifers: GC02M099461 GC02M100612 GC02M100629 GC02M100466 GC02M094773


Summaries
for CHST10 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHST10 Gene:
This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein-
and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human
natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic
plasticity.(provided by RefSeq, Feb 2011)

GeneCards Summary for CHST10 Gene:
CHST10 (carbohydrate sulfotransferase 10) is a protein-coding gene. GO annotations related to this gene include HNK-1 sulfotransferase activity and sulfotransferase activity. An important paralog of this gene is CHST12.

UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529
Function: Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and
lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated
glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell
interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved
in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis

Gene Wiki entry for CHST10 Gene


Genomic Views
for CHST10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHST10 gene promoter:
         TBP   AML1a   MEF-2   CUTL1   Cdc5   HNF-3beta   MEF-2A   RORalpha1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHST10 promoter sequence
   Search Chromatin IP Primers for CHST10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHST10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

CHST10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M101008:  view genomic region     (about GC identifiers)

Start:
 101,008,322 bp from pter      End:
 101,034,130 bp from pter
Size:
 25,809 bases      Orientation:
 minus strand

Proteins
for CHST10 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 10  
Size: 356 amino acids; 42207 Da
Secondary accessions: Q53T18

Explore the universe of human proteins at neXtProt for CHST10: NX_O43529

Explore proteomics data for CHST10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr66, Asn99, Asn228, Asn316
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for CHST10 (O43529) (see all 9)
     YNRTKVE  GHHETLE  LCAPCEI  DFKLFGY 


    See CHST10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004845.1  
    ENSEMBL proteins: 
     ENSP00000264249   ENSP00000387309   ENSP00000387121   ENSP00000405922   ENSP00000387977  
     ENSP00000407525   ENSP00000416831   ENSP00000395643   ENSP00000438869  

    CHST10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CHST10 (Carbohydrate Sulfotransferase 10/CHST10)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CHST10
    OriGene Protein Over-expression Lysate for CHST10
    OriGene MassSpec for CHST10
    OriGene Custom Protein Services for CHST10
    GenScript Custom Purified and Recombinant Proteins Services for CHST10
    Novus Biologicals CHST10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHST10

         		 Search eBioscience for Proteins for CHST10 

         		antibodies-online proteins for CHST10 (2 products) 

         		antibodies-online peptides for CHST10

    CHST10 Antibody Products:

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    Abcam antibodies for CHST10
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    Search ThermoFisher Antibodies for CHST10
    antibodies-online antibodies for CHST10 (19 products) 

    CHST10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHST10
    Cloud-Clone Corp. CLIAs for CHST10
    Search eBioscience for ELISAs for CHST10 
    antibodies-online kits for CHST10 (8 products) 

    Domains /
    Families
    for CHST10 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR005331 Sulfotransferase
     IPR018011 Carb_sulfotransferase-rel

    Graphical View of Domain Structure for InterPro Entry O43529

    ProtoNet protein and cluster: O43529

    UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529
    Similarity: Belongs to the sulfotransferase 2 family


    Find genes that share domains with CHST10           About GenesLikeMe


    Function
    for CHST10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHSTA_HUMAN, O43529
    Function: Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and
    lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated
    glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell
    interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved
    in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis

         Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.22

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity TAS9478973
    GO:0016232HNK-1 sulfotransferase activity IEA--
         
    Find genes that share ontologies with CHST10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CHST10:
     Increased cell number in G1, a 

         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Chst10):
     behavior/neurological  homeostasis/metabolism  nervous system  reproductive system 

    Find genes that share phenotypes with CHST10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CHST10: Chst10tm1Msch Chst10tm1Mifu

       genOway: Develop your customized and physiologically relevant rodent model for CHST10

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat CHST10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST10 (see all 12):
    hsa-miR-137 hsa-miR-130a* hsa-miR-1271 hsa-miR-23c hsa-miR-4299 hsa-miR-182 hsa-miR-23b hsa-miR-143
    SwitchGear 3'UTR luciferase reporter plasmid: CHST10 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for CHST10
    Predesigned siRNA for gene silencing in human, mouse, rat CHST10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CHST10

    Clone
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    OriGene ORF clones in mouse, rat for CHST10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHST10 (NM_004854)
    Sino Biological Human cDNA Clone for CHST10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST10

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CHST10 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST10


    Localization
    for CHST10 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHSTA_HUMAN, O43529: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular3
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus TAS9478973
    GO:0016020membrane TAS9478973
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CHST10           About GenesLikeMe


    Pathways & Interactions
    for CHST10 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHST10 About    
    See pathways by source

    		      Powered
    by    		     
    SuperPathContained pathways About
    1Biological oxidations
    		metapathway biotransformation0.42
    2Other types of O-glycan biosynthesis
    		Other types of O-glycan biosynthesis
    3Articular Cartilage Extracellular Matrix
    		Articular Cartilage Extracellular Matrix


    Find genes that share SuperPaths with CHST10           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CHST10
        Articular Cartilage Extracellular Matrix


    1 BioSystems Pathway for CHST10
        metapathway biotransformation



    1 Kegg Pathway  (Kegg details for CHST10):
        Other types of O-glycan biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Array including CHST10: 
              Cell Surface Markers in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CHST10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CHST10 (O435293 ENSP000002642494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1GP266413I2D: score=1 
    --ENSP000003326984STRING: ENSP00000332698
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS9478973
    GO:0007612learning IEA--
    GO:0007616long-term memory IEA--
    GO:0016051carbohydrate biosynthetic process IEA--

    Find genes that share ontologies with CHST10           About GenesLikeMe



    Drugs & Compounds
    for CHST10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHST10 (CHSTA)

    3 Novoseek inferred chemical compound relationships for CHST10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 81.1 2 11445554 (1)
    sulfate 70.9 4 9478973 (1), 19533738 (1), 10988300 (1)
    glucuronic acid 63.8 1 19533738 (1)



    Find genes that share compounds with CHST10           About GenesLikeMe



    Transcripts
    for CHST10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHST10 gene: 
    NM_004854.4  

    Unigene Cluster for CHST10:

    Carbohydrate sulfotransferase 10
    Hs.516370  [show with all ESTs]
    Unigene Representative Sequence: AF033827
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264249(uc002tam.3) ENST00000409701 ENST00000484382 ENST00000409046
    ENST00000420858 ENST00000448989 ENST00000421474 ENST00000418201 ENST00000435960
    ENST00000485085 ENST00000487860 ENST00000466583 ENST00000542617
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat CHST10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHST10 (see all 12):
    hsa-miR-137 hsa-miR-130a* hsa-miR-1271 hsa-miR-23c hsa-miR-4299 hsa-miR-182 hsa-miR-23b hsa-miR-143
    SwitchGear 3'UTR luciferase reporter plasmid: CHST10 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for CHST10
    Predesigned siRNA for gene silencing in human, mouse, rat CHST10
    Clone
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    OriGene ORF clones in mouse, rat for CHST10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHST10 (NM_004854)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST10
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CHST10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST10
      QuantiTect SYBR Green Assays in human, mouse, rat CHST10
      QuantiFast Probe-based Assays in human, mouse, rat CHST10

    Additional mRNA sequence: 

    AF033827.1 AF070594.1 AK297267.1 AK313241.1 BC010441.1 

    8 DOTS entries:

    DT.115676  DT.120998747  DT.309150  DT.95160052  DT.100761173  DT.100776489  DT.120998751  DT.431181 

    Selected AceView cDNA sequences (see all 154):

    AF070594 BQ029541 Z40274 AI362035 BE046941 AW247310 AW304044 BF941926 
    BM686627 BM703147 AI572361 BQ018982 BM664647 BM453987 AW104630 BE856346 
    BG026467 BM013664 AU108004 AU125990 NM_004854 Z41355 AW135230 CA421420 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHST10 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
    SP1:                                      -     -     -     -     -     -     -     -     -           -     -     -     -                                       
    SP2:                                      -     -     -     -     -     -     -     -     -                 -                                                   
    SP3:                                                  -     -     -     -     -     -     -           -     -     -     -                                       
    SP4:                                                                                      -           -     -     -     -                                       
    SP5:                                                                                                  -     -     -     -                                       

    ExUns: 12d ^ 13a · 13b ^ 14a · 14b
    SP1:        -                     
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CHST10

    Expression
    for CHST10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CHST10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCGCCGA
    CHST10 Expression
    About this image

    CHST10 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    CHST10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516370

    UniProtKB/Swiss-Prot: CHSTA_HUMAN, O43529
    Tissue specificity: In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney
    and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart,
    pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at
    higher level in the frontal lobe

        Pathway & Disease-focused RT2 Profiler PCR Array including CHST10: 
              Cell Surface Markers in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CHST10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHST10
    QuantiTect SYBR Green Assays in human, mouse, rat CHST10
    QuantiFast Probe-based Assays in human, mouse, rat CHST10
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST10

    Orthologs
    for CHST10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for CHST10 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Chst101 , 5 carbohydrate sulfotransferase 101, 5 86.61(n)1
    91.01(a)1    		   1 (17.24 cM)5
    983881  NM_145142.21  NP_660124.21 
     388638775 
    chicken
    (Gallus gallus)    		 Aves CHST101 carbohydrate sulfotransferase 10 78.28(n)
    85.96(a)    		   395206  NM_001030343.1  NP_001025514.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CHST106
    		 carbohydrate sulfotransferase 10
    		 85(a)
    		 1 ↔ 1
    		 GL343456.1(625180-639748)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.82392 Xenopus laevis transcribed sequence with moderate similarity more 77.17(n)    48024128 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.118342 Transcribed sequence with weak similarity to protein more 75.08(n)    CA471403.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG140246
    CG139376
    		 --
    		 18(a)
    17(a)
    		 many ↔ many
    many ↔ many
    		 2L(5311311-5314885)
    3L(1876551-1883041)


    ENSEMBL Gene Tree for CHST10 (if available)
    TreeFam Gene Tree for CHST10 (if available)

    Paralogs
    for CHST10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHST10 gene
    CHST122  CHST132  CHST92  CHST112  CHST82  CHST142  
    4 SIMAP similar genes for CHST10 using alignment to 8 protein entries:     CHSTA_HUMAN (see all proteins):
    CHST11    CHST9    CHST13    CHST8

    Find genes that share paralogs with CHST10           About GenesLikeMe



    Genomic Variants
    for CHST10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHST10 (see all 665)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs98084801,2
    		C,F,H--100663742(+) TGGTAG/ACAATC 1 -- int19Minor allele frequency- A:0.10NS EA NA WA 1206
    rs1857947431,2
    		--100663928(+) TAATCA/GATCAG 1 -- int10--------
    rs1164304611,2
    		F--100664045(+) CCTGCG/AGTCTG 1 -- int12Minor allele frequency- A:0.03WA NA 238
    rs67552851,2
    		C,F,A,H--100664059(+) ACCCTG/AAGCAG 1 -- int120Minor allele frequency- A:0.18NS EA WA NA CSA 2213
    rs1459537301,2
    		--100664103(+) GCCTGA/GGGCGC 1 -- int10--------
    rs755284201,2
    		C--100664136(+) CAGAAA/CCGCAG 1 -- int10--------
    rs1422380431,2
    		--100664200(+) AGGAAA/GCCATT 1 -- ut310--------
    rs1903531191,2
    		--100664223(+) AGAGGC/TCGCCT 1 -- ut310--------
    rs1822311041,2
    		--100664343(+) GACGGC/TATCTG 1 -- ut310--------
    rs10570641,2
    		C,F,A,H--100664392(-) CCTGGC/TAACAA 1 -- ut31 ese310Minor allele frequency- T:0.14MN NS EA WA NA 934

    HapMap Linkage Disequilibrium report for CHST10 (101008322 - 101034130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CHST10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874701CNV Gain21882294
    nsv829583CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHST10
    DNA2.0 Custom Variant and Variant Library Synthesis for CHST10

    Disorders / Diseases
    for CHST10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 606376    OMIM disorders: --


    Find genes that share disorders with CHST10           About GenesLikeMe

    Genetic Association Database (GAD): CHST10
    Human Genome Epidemiology (HuGE) Navigator: CHST10 (2 documents)

    Export disorders for CHST10 gene to outside databases

    Publications
    for CHST10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHST10 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CHST10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis. (PubMed id 10464296)1, 2, 9 Ong E....Fukuda M. (J. Biol. Chem. 1999)
    2. Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids. (PubMed id 9478973)1, 2, 9 Ong E.... Fukuda M. (J. Biol. Chem. 1998)
    3. Molecular cloning and characterization of chondroitin-4-O- sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases. (PubMed id 12080076)1, 3, 9 Kang H.-G.... Schachner M. (J. Biol. Chem. 2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. (PubMed id 19470764)1, 9 Zhao X....Spanjaard R.A. (Cancer Res. 2009)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate transfer regulates laminin-binding glycans on I+-dystroglycan. (PubMed id 22801424)1 Nakagawa N....Oka S. (J. Biol. Chem. 2012)
    8. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    9. Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin. (PubMed id 22020094)1 Nakagawa N....Oka S. (Biochem. Biophys. Res. Commun. 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    External Searches for CHST10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    Genome Databases showing CHST10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9486 HGNC: 19650 AceView: CHST10 Ensembl:ENSG00000115526 euGenes: HUgn9486
    ECgene: CHST10 Kegg: 9486 H-InvDB: CHST10

    Other Databases showing CHST10 gene

    (According to HUGE)
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    Specialized Databases showing CHST10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHST10 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CHST10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    TryGeneCards Plus    		Patent Information for CHST10 gene:
    Search GeneIP for patents involving CHST10

    GeneCards and IP:
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