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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CHST1 Gene

protein-coding GIFtS: 60
GCID: GC11M045670

carbohydrate (keratan sulfate Gal-6) sulfotransferase 1

Explore 7 diseases affiliated with
CHST1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Carbohydrate (Keratan Sulfate Gal-6) Sulfotransferase 1¹ ²		EC 2.8.2.21³ ⁸
KSGal6ST¹ ² ³		Carbohydrate (Chondroitin 6/Keratan) Sulfotransferase 1²
C6ST¹ ²		Carbohydrate Sulfotransferase 1²
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 1² ³		Keratan Sulfate Gal-6 Sulfotransferase³
GST-1² ³		KSGAL6ST⁵
KS6ST² ³		EC 2.8.2⁸
KSST² ³

External Ids:	HGNC: 1969¹	Entrez Gene: 8534²	Ensembl: ENSG00000175264⁷	OMIM: 603797⁵	UniProtKB: O43916³

Export aliases for CHST1 gene to outside databases

Previous GC identifers: GC11M047454 GC11M046360 GC11M045702 GC11M045634 GC11M045627 GC11M045378

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHST1:

This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the

sulfation of the proteoglycan keratin. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: CHST1_HUMAN, O43916

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the

transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan

sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc

structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated.

May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins.

Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and

play a central role in lymphocyte homing at sites of inflammation

Gene Wiki entry for CHST1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CHST1 gene promoter:
LHX3b/Lhx3b C/EBPbeta LCR-F1 NF-kappaB Max AREB6 HOXA5 NF-kappaB2 LHX3a/Lhx3a NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHST1 promoter sequence

Search SABiosciences Chromatin IP Primers for CHST1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2

CHST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M045670: view genomic region (about GC identifiers)

Start:	45,670,427 bp from pter	End:	45,687,172 bp from pter
Size:	16,746 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHST1_HUMAN, O43916 (See protein sequence)

Recommended Name: Carbohydrate sulfotransferase 1

Size: 411 amino acids; 46715 Da

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)

Caution: Was originally (PubMed:9639683) thought to be the ortholog of chicken CHST3 and therefore named C6ST. However,

it has no strong chondroitin 6-sulfotransferase activity

Secondary accessions: D3DQP2

Explore the universe of human proteins at neXtProt for CHST1: NX_O43916

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43916

4/11 DME Specific Peptides for CHST1 (O43916) (see all 11)

LVEDPRL

CDLYFLE

YMLVRYED

TGRKPYNLD

CHST1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003645.1

ENSEMBL proteins:

ENSP00000309270

Reactome Protein details: O43916
Human Recombinant Protein Products:

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	Novus Biologicals CHST1 Protein Novus Biologicals CHST1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CHST1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0016021	integral to membrane	NAS	9405439

CHST1 for ontologies About GeneDecksing

CHST1 Antibody Products:

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	Uscn ELISAs and CLIAs for CHST1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CHST1 for domains About GeneDecksing

2 InterPro domains/families:

IPR016469 Carbohydrate_sulfotransferase

IPR000863 Sulfotransferase_dom

Graphical View of Domain Structure for InterPro Entry O43916

ProtoNet protein and cluster: O43916

UniProtKB/Swiss-Prot: CHST1_HUMAN, O43916

Similarity: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CHST1_HUMAN, O43916

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the

transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan

sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc

structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated.

May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins.

Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and

play a central role in lymphocyte homing at sites of inflammation

Catalytic activity: 3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate

Genatlas biochemistry entry for CHST1:

chondroitin 6-sulfotransferase key enzyme 1,expressed in vascular endothelial cells,implicated in

chondrogenesis,neoplasia,atherosclerosis and other

Enzyme Numbers (IUBMB): EC 2.8.2.21¹ ² EC 2.8.2²

miRNA Products:		OriGene 3'-UTR Clone: CHST1 Browse MicroRNA Expression Plasmids
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		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST1 (see all 45):
		hsa-miR-579 hsa-miR-25 hsa-miR-128 hsa-miR-30d hsa-miR-301a hsa-miR-570 hsa-miR-30a hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: CHST1 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: CHST1 (NM_003654)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008146	sulfotransferase activity	IDA	10330415
GO:0045130	keratan sulfotransferase activity	IDA	9405439

CHST1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CHST1:

Decreased POU5F1-GFP protein e

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/14 pathways (see all 14)
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS I - Hurler syndrome	1.00	MPS IIID - Sanfilippo syndrome D	1.00
Mucopolysaccharidoses	1.00	MPS IX - Natowicz syndrome	1.00
MPS IV - Morquio syndrome A	1.00	MPS II - Hunter syndrome	1.00

Keratan sulfate biosynthesis

	Keratan sulfate biosynthesis	1.00			Glycosaminoglycan biosynthesis - keratan sulfate	0.45
	Keratan sulfate/keratin metabolism	0.84

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Articular Cartilage Extracellular Matrix

Articular Cartilage Extracellular Matrix

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for CHST1

Articular Cartilage Extracellular Matrix

1 BioSystems Pathway for CHST1

metapathway biotransformation

5/18 Reactome Pathways for CHST1 (see all 18)

	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	Keratan sulfate/keratin metabolism
	MPS II - Hunter syndrome

1 Kegg Pathway (Kegg details for CHST1):

Glycosaminoglycan biosynthesis - keratan sulfate

CHST1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CHST1

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/12 Interacting proteins for CHST1 (O43916^{2, 3} ENSP00000309270⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947²^,³, ENSP00000340989⁴	MINT-67184 I2D: score=5 STRING: ENSP00000340989
CHST2	ENSP00000307911⁴	STRING: ENSP00000307911
CHST5	ENSP00000338783⁴	STRING: ENSP00000338783
CHST6	ENSP00000328983⁴	STRING: ENSP00000328983
KERA	ENSP00000266719⁴	STRING: ENSP00000266719

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0005976	polysaccharide metabolic process	TAS	9405439
GO:0006012	galactose metabolic process	IDA	10330415
GO:0006790	sulfur compound metabolic process	IDA	10330415
GO:0006954	inflammatory response	IEA	--

CHST1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CHST1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CHST1

2 HMDB Compounds for CHST1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Keratan	Kerato sulfate (see all 4)	69992-87-6	--
N-Acetyllactosamine	D-galactopyranosyl (see all 8)	32181-59-2	--

7 Novoseek chemical compound relationships for CHST1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
keratan sulfate	88.8	31	9405439 (5), 8991509 (3), 10642612 (2), 9147050 (2) (see all 8)
3-phosphoadenosine 5'-phosphosulfate	82.9	7	8991509 (1), 9639683 (1), 10642612 (1)
chondroitin	82.8	17	9405439 (2), 9639683 (2), 9147050 (2), 10049591 (1) (see all 6)
n-acetylglucosamine	64.2	2	10510083 (1), 8991509 (1)
sulfate	56.7	14	10642612 (4), 9147050 (3), 8991509 (2), 9639683 (1)
glycosaminoglycan	43.5	1	9639683 (1)
galactose	35.2	2	10510083 (1), 8991509 (1)

Search CenterWatch for drugs/clinical trials and news about CHST1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CHST1 gene:

NM_003654.5

Unigene Cluster for CHST1:

Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1

Hs.104576 [show with all ESTs]

Unigene Representative Sequence: NM_003654

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000308064(uc001mys.2) ENST00000533673 ENST00000531322

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST1
		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST1 (see all 45):
		hsa-miR-579 hsa-miR-25 hsa-miR-128 hsa-miR-30d hsa-miR-301a hsa-miR-570 hsa-miR-30a hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: CHST1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST1

Additional cDNA sequence:

AB003791.1 AF090137.1 BC022567.1 BC028235.1 U65637.1

3 DOTS entries:

DT.111174 DT.303803 DT.443402

24/75 AceView cDNA sequences (see all 75):

BQ716781 AI571222 AI933050 AI570525 BE350210 AW005528 AW196477 AI656107

AW510923 AI828098 AA682945 AF090137 AW235312 AI698458 AA582419 BQ669099

BM975834 AI280113 BM665520 BQ003703 CA413195 U65637 AI692548 BC028235

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CHST1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGTTGGGT

About this image

CHST1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

GABAergic Amacrine Cells

Amacrine, Retina

Testis

Seminiferous Tubules

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CHST1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHST1

SOURCE GeneReport for Unigene cluster: Hs.104576

UniProtKB/Swiss-Prot: CHST1_HUMAN, O43916

Tissue specificity: Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high

endothelial cells (HEVs) and leukocytes

SABiosciences Expression via Pathway-Focused PCR Array including CHST1:

Drug Metabolism in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CHST1 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CHST1¹	carbohydrate (keratan sulfate Gal-6) sulfotransferase more	82.4(n) 86.37(a)		428866 XM_426423.3 XP_426423.2
lizard (Anolis carolinensis)	Reptilia	CHST1⁶	--	82(a)	1 ↔ 1	1(47485753-47486868)
zebrafish (Danio rerio)	Actinopterygii	chst1¹	carbohydrate (keratan sulfate Gal-6) sulfotransferase more	66.99(n) 73.17(a)		445124 NM_001003518.1 NP_001003518.1
fruit fly (Drosophila melanogaster)	Insecta	CG31637¹	CG31637	46.6(n) 29.25(a)		33914 NM_135199.2 NP_609043.1

ENSEMBL Gene Tree for CHST1 (if available)
TreeFam Gene Tree for CHST1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CHST1 gene

CHST4² CHST2² CHST3² CHST6² CHST7² CHST5²

4 SIMAP similar genes for CHST1 using alignment to 1 protein entry: CHST1_HUMAN:

CHST3 CHST4 CHST6 CHST5

CHST1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35698128^1,2	C,	--	45668825(+)	`CCAAAG/-AATGG`	1	--	ds500¹		1		NA	2
rs138521988^1,2		--	45668843(+)	`GGTCTC/GAAGAG`	1	--	ds500¹		0	--	--	--	--
rs111599696^1,2		--	45668855(+)	`CAGTTG/CTACAC`	1	--	ds500¹		1		CSA	2
rs187682497^1,2		--	45668903(+)	`ATGGAA/GGCAAC`	1	--	ds500¹		0	--	--	--	--
rs190636139^1,2		--	45668906(+)	`GAAGCA/CACCCA`	1	--	ds500¹		0	--	--	--	--
rs144482130^1,2		--	45668911(+)	`AACCCA/TAGTGT`	1	--	ds500¹		0	--	--	--	--
rs72896778^1,2	C,F,	--	45669006(+)	`ACATAT/AGCTGC`	1	--	ds500¹		2		NA EA	240
rs148771707^1,2		--	45669008(+)	`ATATGC/TTGCAA`	1	--	ds500¹		0	--	--	--	--
rs78950319^1,2	C,F,	--	45669063(+)	`TCATAA/GAAGGA`	1	--	ds500¹		1		NA	120
rs182856881^1,2		--	45669406(+)	`GAACTA/GTCTAC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CHST1 (45670427 - 45687172 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CHST1
1 CNV: 65934

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CHST1 for disorders           About GeneDecksing

OMIM gene information: 603797    OMIM disorders: --

7 diseases for CHST1:    About MalaCards

spondyloepiphyseal dysplasia omani type spondyloepiphyseal dysplasia macular corneal dystrophy corneal dystrophy

atherosclerosis glioblastoma immunodeficiency

1 Novoseek disease relationship for CHST1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	0	1	11310842 (1)

Human Genome Epidemiology (HuGE) Navigator: CHST1 (3 documents)

Export disorders for CHST1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CHST1 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with CHST1)

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Molecular cloning and characterization of human keratan sulfate Gal- 6-sulfotransferase. (PubMed id 9405439)^{1, 2, 3, 9} Fukuta M.... Habuchi O. (1997)
Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization. (PubMed id 9639683)^{1, 2, 3, 9} Mazany K.D.... Williams K.J. (1998)
Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase. (PubMed id 10642612)^{1, 2, 9} Torii T.... Habuchi O. (2000)
CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. (PubMed id 11310842)^{1, 2, 9} Li X.... Tedder T.F. (2001)
CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. (PubMed id 10049591)^{1, 2, 9} Li X. and Tedder T.F. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. (PubMed id 10330415)^{1, 2} Bistrup A.... Hemmerich S. (1999)
L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1. (PubMed id 10528213)^{1, 9} Tu L....Tedder T.F. (1999)
Expression of long-form N-acetylglucosamine-6-O-sulfot ransferase 1 in human high endothelial venules. (PubMed id 22260995)¹ Fujiwara M....Nakayama J. (2012)
Novel O-linked glycans containing 6'-sulfo-Gal/GalNAc of MUC1 secreted from human breast cancer YMB-S cells: possible carbohydrate epi topes of KL-6(MUC1) monoclonal antibody. (PubMed id 21880669)¹ Seko A....Yamashita K. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8534	HGNC: 1969	AceView: CHST1	Ensembl:ENSG00000175264	euGenes: HUgn8534
ECgene: CHST1	Kegg: 8534	H-InvDB: CHST1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CHST1	Pharmacogenomics, SNPs, Pathways
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/
NIEHS-SNPs	http://egp.gs.washington.edu/data/chst1/

Intellectual Property for CHST1 gene
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Patent Information for CHST1 gene:
Search GeneIP for patents involving CHST1

GeneCards and IP:
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carbohydrate (keratan sulfate Gal-6) sulfotransferase 1

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carbohydrate (keratan sulfate Gal-6) sulfotransferase 1

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