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Aliases for CHST1 Gene

Aliases for CHST1 Gene

  • Carbohydrate (Keratan Sulfate Gal-6) Sulfotransferase 1 2 3
  • Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 1 3 4
  • EC 2.8.2.21 4 63
  • KSGal6ST 3 4
  • GST-1 3 4
  • KS6ST 3 4
  • KSST 3 4
  • Carbohydrate (Chondroitin 6/Keratan) Sulfotransferase 1 3
  • Keratan Sulfate Gal-6 Sulfotransferase 4
  • EC 2.8.2 63
  • C6ST 3

External Ids for CHST1 Gene

Previous GeneCards Identifiers for CHST1 Gene

  • GC11M047454
  • GC11M046360
  • GC11M045702
  • GC11M045634
  • GC11M045627
  • GC11M045378
  • GC11M045670

Summaries for CHST1 Gene

Entrez Gene Summary for CHST1 Gene

  • This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST1 Gene

CHST1 (Carbohydrate (Keratan Sulfate Gal-6) Sulfotransferase 1) is a Protein Coding gene. Diseases associated with CHST1 include spondyloepiphyseal dysplasia with congenital joint dislocations. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and keratan sulfotransferase activity. An important paralog of this gene is CHST2.

UniProtKB/Swiss-Prot for CHST1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.

Gene Wiki entry for CHST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST1 Gene

Genomics for CHST1 Gene

Genomic Location for CHST1 Gene

Chromosome:
11
Start:
45,647,689 bp from pter
End:
45,665,656 bp from pter
Size:
17,968 bases
Orientation:
Minus strand

Genomic View for CHST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST1 Gene

Proteins for CHST1 Gene

  • Protein details for CHST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43916-CHST1_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 1
    Protein Accession:
    O43916
    Secondary Accessions:
    • D3DQP2

    Protein attributes for CHST1 Gene

    Size:
    411 amino acids
    Molecular mass:
    46715 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHST1 Gene

Proteomics data for CHST1 Gene at MOPED

Post-translational modifications for CHST1 Gene

  • Glycosylation at Asn 56, Asn 145, Asn 189, and Asn 334
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CHST1 (Carbohydrate Sulfotransferase 1/CHST1)

Domains & Families for CHST1 Gene

Gene Families for CHST1 Gene

Protein Domains for CHST1 Gene

Suggested Antigen Peptide Sequences for CHST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43916

UniProtKB/Swiss-Prot:

CHST1_HUMAN :
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Family:
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
genes like me logo Genes that share domains with CHST1: view

Function for CHST1 Gene

Molecular function for CHST1 Gene

GENATLAS Biochemistry:
chondroitin 6-sulfotransferase key enzyme 1,expressed in vascular endothelial cells,implicated in chondrogenesis,neoplasia,atherosclerosis and other
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + keratan = adenosine 3,5-bisphosphate + keratan 6-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.

Enzyme Numbers (IUBMB) for CHST1 Gene

Gene Ontology (GO) - Molecular Function for CHST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity IBA --
GO:0008146 sulfotransferase activity IDA 10330415
GO:0045130 keratan sulfotransferase activity IDA 9405439
genes like me logo Genes that share ontologies with CHST1: view
genes like me logo Genes that share phenotypes with CHST1: view

Animal Models for CHST1 Gene

MGI Knock Outs for CHST1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHST1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CHST1 Gene

Localization for CHST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST1 Gene COMPARTMENTS Subcellular localization image for CHST1 gene
Compartment Confidence
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for CHST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane NAS 9405439
genes like me logo Genes that share ontologies with CHST1: view

Pathways & Interactions for CHST1 Gene

genes like me logo Genes that share pathways with CHST1: view

Pathways by source for CHST1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005976 polysaccharide metabolic process TAS 9405439
GO:0006012 galactose metabolic process IDA 10330415
GO:0006790 sulfur compound metabolic process IDA 10330415
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with CHST1: view

No data available for SIGNOR curated interactions for CHST1 Gene

Drugs & Compounds for CHST1 Gene

(1) Drugs for CHST1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chondroitin Nutra 40

(10) Additional Compounds for CHST1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Keratan
  • Keratan 6'-sulfate
  • Keratan 6'-sulphate
  • Keratan sulfate
  • Keratan sulphate
  • Kerato 6'-sulfate
69992-87-6
n-acetyllactosamine
  • beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • beta-D-Galactosyl-1,4-N-acetyl-D-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-beta-delta-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-delta-glucosamine
  • D-Galactopyranosyl
32181-59-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
3-phosphoadenosine 5-phosphosulfate
genes like me logo Genes that share compounds with CHST1: view

Transcripts for CHST1 Gene

mRNA/cDNA for CHST1 Gene

Unigene Clusters for CHST1 Gene

Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHST1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST1 Gene

No ASD Table

Relevant External Links for CHST1 Gene

GeneLoc Exon Structure for
CHST1
ECgene alternative splicing isoforms for
CHST1

Expression for CHST1 Gene

mRNA expression in normal human tissues for CHST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST1 Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.6), and Brain - Amygdala (x4.0).

SOURCE GeneReport for Unigene cluster for CHST1 Gene Hs.104576

mRNA Expression by UniProt/SwissProt for CHST1 Gene

O43916-CHST1_HUMAN
Tissue specificity: Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes.
genes like me logo Genes that share expression patterns with CHST1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CHST1 Gene

Orthologs for CHST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHST1 35
  • 92.86 (n)
  • 97.81 (a)
CHST1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHST1 35
  • 93.67 (n)
  • 98.3 (a)
CHST1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chst1 35
  • 86.67 (n)
  • 94.39 (a)
Chst1 16
Chst1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHST1 35
  • 99.59 (n)
  • 100 (a)
CHST1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chst1 35
  • 87.8 (n)
  • 95.37 (a)
oppossum
(Monodelphis domestica)
Mammalia CHST1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHST1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHST1 35
  • 82.4 (n)
  • 86.37 (a)
CHST1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chst1 35
  • 66.26 (n)
  • 75 (a)
zebrafish
(Danio rerio)
Actinopterygii chst1 35
  • 66.99 (n)
  • 73.17 (a)
chst1 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31637 36
  • 18 (a)
ManyToMany
CG9550 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
CSA.5535 36
  • 21 (a)
ManyToMany
Species with no ortholog for CHST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST1 Gene

ENSEMBL:
Gene Tree for CHST1 (if available)
TreeFam:
Gene Tree for CHST1 (if available)

Paralogs for CHST1 Gene

Paralogs for CHST1 Gene

(4) SIMAP similar genes for CHST1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHST1: view

Variants for CHST1 Gene

Sequence variations from dbSNP and Humsavar for CHST1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs895729 -- 45,657,647(+) ATGTG(A/G)GCAGT intron-variant
rs895730 -- 45,657,662(+) CAACA(C/T)ACAAT intron-variant
rs895731 -- 45,661,183(+) GCCCT(A/T)AGCAC intron-variant
rs895732 -- 45,661,273(+) GAGGG(C/G)CGCAA intron-variant
rs895733 -- 45,662,567(+) TCTAG(G/T)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST1 Gene

Variant ID Type Subtype PubMed ID
dgv1088n71 CNV Loss 21882294
esv24804 CNV Loss 19812545

Variation tolerance for CHST1 Gene

Residual Variation Intolerance Score: 12.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHST1 Gene

HapMap Linkage Disequilibrium report
CHST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST1 Gene

Disorders for CHST1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CHST1 Gene - From: OMIM

Disorder Aliases PubMed IDs
spondyloepiphyseal dysplasia with congenital joint dislocations
  • chondrodysplasia with multiple dislocations
- elite association
Search CHST1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHST1

Genetic Association Database (GAD)
CHST1
Human Genome Epidemiology (HuGE) Navigator
CHST1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHST1
genes like me logo Genes that share disorders with CHST1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHST1 Gene

Publications for CHST1 Gene

  1. Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization. (PMID: 9639683) Mazany K.D. … Williams K.J. (Biochim. Biophys. Acta 1998) 2 23 67
  2. Molecular cloning and characterization of human keratan sulfate Gal- 6-sulfotransferase. (PMID: 9405439) Fukuta M. … Habuchi O. (J. Biol. Chem. 1997) 2 23 67
  3. Expression of highly sulfated keratan sulfate synthesized in human glioblastoma cells. (PMID: 18211804) Hayatsu N. … Narimatsu H. (Biochem. Biophys. Res. Commun. 2008) 23 67
  4. Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. (PMID: 17716855) Westerink W.M. … Schoonen W.G. (Toxicol In Vitro 2007) 23 67
  5. Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes. (PMID: 15681896) Nishimura M. … Naito S. (Drug Metab. Pharmacokinet. 2004) 23 67

Products for CHST1 Gene

Sources for CHST1 Gene

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