Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHST1 Gene

protein-coding   GIFtS: 62
GCID: GC11M045670

Carbohydrate (Keratan Sulfate Gal-6) Sulfotransferase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carbohydrate (Keratan Sulfate Gal-6) Sulfotransferase 11 2     C6ST2
Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 12 3     Carbohydrate (Chondroitin 6/Keratan) Sulfotransferase 12
GST-12 3     Carbohydrate Sulfotransferase 12
KS6ST2 3     Keratan Sulfate Gal-6 Sulfotransferase3
KSGal6ST2 3     KSGAL6ST5
KSST2 3     EC 2.8.28
EC 2.8.2.213 8     

External Ids:    HGNC: 19691   Entrez Gene: 85342   Ensembl: ENSG000001752647   OMIM: 6037975   UniProtKB: O439163   

Export aliases for CHST1 gene to outside databases

Previous GC identifers: GC11M047454 GC11M046360 GC11M045702 GC11M045634 GC11M045627 GC11M045378


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHST1 Gene:
This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the
sulfation of the proteoglycan keratin. (provided by RefSeq, Aug 2011)

GeneCards Summary for CHST1 Gene: 
CHST1 (carbohydrate (keratan sulfate Gal-6) sulfotransferase 1) is a protein-coding gene. Diseases associated with CHST1 include spondyloepiphyseal dysplasia omani type, and macular corneal dystrophy, and among its related super-pathways are Keratan sulfate/keratin metabolism and Metabolism of carbohydrates. GO annotations related to this gene include sulfotransferase activity and keratan sulfotransferase activity. An important paralog of this gene is CHST4.

UniProtKB/Swiss-Prot: CHST1_HUMAN, O43916
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan
sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc
structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are
sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to
glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial
cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation

Gene Wiki entry for CHST1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHST1 gene promoter:
         LHX3b/Lhx3b   C/EBPbeta   LCR-F1   NF-kappaB   Max   AREB6   HOXA5   NF-kappaB2   LHX3a/Lhx3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHST1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHST1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

CHST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHST1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M045670:  view genomic region     (about GC identifiers)

Start:
45,670,427 bp from pter      End:
45,687,172 bp from pter
Size:
16,746 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHST1_HUMAN, O43916 (See protein sequence)
Recommended Name: Carbohydrate sulfotransferase 1  
Size: 411 amino acids; 46715 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Caution: Was originally (PubMed:9639683) thought to be the ortholog of chicken CHST3 and therefore named C6ST.
However, it has no strong chondroitin 6-sulfotransferase activity
Secondary accessions: D3DQP2

Explore the universe of human proteins at neXtProt for CHST1: NX_O43916

Explore proteomics data for CHST1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43916

  • 4/11 DME Specific Peptides for CHST1 (O43916) (see all 11)
     LVEDPRL  CDLYFLE  YMLVRYED  TGRKPYNLD 

    CHST1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHST1 Protein Expression
    REFSEQ proteins: NP_003645.1  
    ENSEMBL proteins: 
     ENSP00000309270  
    Reactome Protein details: O43916
    Human Recombinant Protein Products for CHST1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CHST1 (Carbohydrate Sulfotransferase 1/CHST1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CHST1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CHST1
    GenScript Custom Purified and Recombinant Proteins Services for CHST1
    Novus Biologicals CHST1 Protein
    Novus Biologicals CHST1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHST1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane NAS9405439

    CHST1 for ontologies           About GeneDecksing



    CHST1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CHST1 (Carbohydrate Sulfotransferase 1/CHST1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CHST1
    GenScript Custom Superior Antibodies Services for CHST1
    Novus Biologicals CHST1 Antibodies
    Abcam antibodies for CHST1
    Cloud-Clone Corp. Antibodies for CHST1 
    Search ThermoFisher Antibodies for CHST1
    LSBio Antibodies in human, mouse, rat for CHST1 

    Assay Products for CHST1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHST1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHST1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHST1 
    Cloud-Clone Corp. CLIAs for CHST1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR016469 Carbohydrate_sulfotransferase
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry O43916

    ProtoNet protein and cluster: O43916

    UniProtKB/Swiss-Prot: CHST1_HUMAN, O43916
    Similarity: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily


    CHST1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHST1_HUMAN, O43916
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan
    sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc
    structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are
    sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to
    glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial
    cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation
    Catalytic activity: 3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate

         Genatlas biochemistry entry for CHST1:
    chondroitin 6-sulfotransferase key enzyme 1,expressed in vascular endothelial cells,implicated in
    chondrogenesis,neoplasia,atherosclerosis and other

         Enzyme Numbers (IUBMB): EC 2.8.2.211 2 EC 2.8.22

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity IDA10330415
    GO:0045130keratan sulfotransferase activity IDA9405439
         
    CHST1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHST1:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHST1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHST1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHST1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHST1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST1
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST1 (see all 45):
    hsa-miR-579 hsa-miR-25 hsa-miR-128 hsa-miR-30d hsa-miR-301a hsa-miR-570 hsa-miR-30a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCHST1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHST1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHST1
    Sirion Biotech Customized adenovirus for overexpression of CHST1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CHST1 (see all 7)
    OriGene ORF clones in mouse, rat for CHST1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHST1 (NM_003654)
    Sino Biological Human cDNA Clone for CHST1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST1
    Sirion Biotech Customized lentivirus for stable overexpression of CHST1 
                         Customized lentivirus expression plasmids for stable overexpression of CHST1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHST1
    Search LifeMap BioReagents cell lines for CHST1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHST1 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Keratan sulfate biosynthesis
    Keratan sulfate biosynthesis0.82
    Glycosaminoglycan biosynthesis - keratan sulfate0.43
    Keratan sulfate/keratin metabolism0.82
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    3Biological oxidations
    metapathway biotransformation0.41
    4Metabolism
    Metabolism0.40
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CHST1
        Articular Cartilage Extracellular Matrix


    1 BioSystems Pathway for CHST1
        metapathway biotransformation


    5/18        Reactome Pathways for CHST1 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS II - Hunter syndrome


    1         Kegg Pathway  (Kegg details for CHST1):
        Glycosaminoglycan biosynthesis - keratan sulfate


    CHST1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHST1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for CHST1 (O439162, 3 ENSP000003092704) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3, ENSP000003409894MINT-67184 I2D: score=5 STRING: ENSP00000340989
    CHST2ENSP000003079114STRING: ENSP00000307911
    CHST5ENSP000003387834STRING: ENSP00000338783
    CHST6ENSP000003289834STRING: ENSP00000328983
    KERAENSP000002667194STRING: ENSP00000266719
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0005976polysaccharide metabolic process TAS9405439
    GO:0006012galactose metabolic process IDA10330415
    GO:0006790sulfur compound metabolic process IDA10330415
    GO:0006954inflammatory response IEA--

    CHST1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHST1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHST1

    2 HMDB Compounds for CHST1    About this table
    CompoundSynonyms CAS #PubMed Ids
    KeratanKerato sulfate (see all 4)69992-87-6--
    N-AcetyllactosamineD-galactopyranosyl (see all 8)32181-59-2--

    7 Novoseek inferred chemical compound relationships for CHST1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    keratan sulfate 88.8 31 9405439 (5), 8991509 (3), 10642612 (2), 9147050 (2) (see all 8)
    3-phosphoadenosine 5'-phosphosulfate 82.9 7 8991509 (1), 9639683 (1), 10642612 (1)
    chondroitin 82.8 17 9405439 (2), 9639683 (2), 9147050 (2), 10049591 (1) (see all 6)
    n-acetylglucosamine 64.2 2 10510083 (1), 8991509 (1)
    sulfate 56.7 14 10642612 (4), 9147050 (3), 8991509 (2), 9639683 (1)
    glycosaminoglycan 43.5 1 9639683 (1)
    galactose 35.2 2 10510083 (1), 8991509 (1)

    Search CenterWatch for drugs/clinical trials and news about CHST1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHST1 gene: 
    NM_003654.5  

    Unigene Cluster for CHST1:

    Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
    Hs.104576  [show with all ESTs]
    Unigene Representative Sequence: NM_003654
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308064(uc001mys.2) ENST00000533673 ENST00000531322
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHST1
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate CHST1 (see all 45):
    hsa-miR-579 hsa-miR-25 hsa-miR-128 hsa-miR-30d hsa-miR-301a hsa-miR-570 hsa-miR-30a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCHST1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHST1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST1
    Clone
    Products:
         
    OriGene clones in human, mouse for CHST1 (see all 7)
    OriGene ORF clones in mouse, rat for CHST1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHST1 (NM_003654)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST1
    Sirion Biotech Customized lentivirus for stable overexpression of CHST1 
                         Customized lentivirus expression plasmids for stable overexpression of CHST1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHST1
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHST1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST1

    Additional mRNA sequence: 

    AB003791.1 AF090137.1 BC022567.1 BC028235.1 U65637.1 

    3 DOTS entries:

    DT.111174  DT.303803  DT.443402 

    24/75 AceView cDNA sequences (see all 75):

    AW196477 AW005528 AI828098 AI933050 AW510923 AI656107 BE350210 AI698458 
    AA682945 AW235312 BQ716781 AI570525 AA582419 AF090137 AI571222 AI797769 
    BC022567 BE467344 AB003791 BE673880 BM975834 BQ669099 BM665520 AI701541 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHST1 expression in normal human tissues (normalized intensities)      CHST1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTTGGGT
    CHST1 Expression
    About this image


    CHST1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             Human Brain Microvascular Endothelial Cells (HBMEC)   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
     
     Kidney (Urinary System)
             Renal Vesicle

    See CHST1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHST1

    SOURCE GeneReport for Unigene cluster: Hs.104576

    UniProtKB/Swiss-Prot: CHST1_HUMAN, O43916
    Tissue specificity: Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high
    endothelial cells (HEVs) and leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including CHST1: 
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHST1
    OriGene qSTAR qPCR primer pairs in human, mouse for CHST1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHST1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHST1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chst11 , 5 carbohydrate (keratan sulfate Gal-6) sulfotransferase more1, 5 86.67(n)1
    94.39(a)1
      2 (51.17 cM)5
    769691  NM_023850.21  NP_076339.11 
     925997075 
    chicken
    (Gallus gallus)
    Aves CHST11 carbohydrate (keratan sulfate Gal-6) sulfotransferase more 82.4(n)
    86.37(a)
      428866  XM_426423.3  XP_426423.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHST16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    1(47485609-47486868)
    zebrafish
    (Danio rerio)
    Actinopterygii chst11 carbohydrate (keratan sulfate Gal-6) sulfotransferase more 66.99(n)
    73.17(a)
      445124  NM_001003518.1  NP_001003518.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316371 CG31637 46.6(n)
    29.25(a)
      33914  NM_135199.2  NP_609043.1 


    ENSEMBL Gene Tree for CHST1 (if available)
    TreeFam Gene Tree for CHST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHST1 gene
    CHST42  CHST22  CHST32  CHST62  CHST72  CHST52  
    4 SIMAP similar genes for CHST1 using alignment to 1 protein entry:     CHST1_HUMAN:
    CHST3    CHST4    CHST6    CHST5

    CHST1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/411 SNPs in CHST1 are shown (see all 411)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356981281,2
    C--45668825(+) CCAAAG/-AATGG 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1477005341,2
    C--45668826(+) CAAAA-/GATGGA 1 -- ds50010--------
    rs1385219881,2
    --45668843(+) GGTCTC/GAAGAG 1 -- ds50010--------
    rs1115996961,2
    F--45668855(+) CAGTTG/CTACAC 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1876824971,2
    --45668903(+) ATGGAA/GGCAAC 1 -- ds50010--------
    rs1906361391,2
    --45668906(+) GAAGCA/CACCCA 1 -- ds50010--------
    rs1444821301,2
    --45668911(+) AACCCA/TAGTGT 1 -- ds50010--------
    rs728967781,2
    C,F--45669006(+) ACATAT/AGCTGC 1 -- ds50012Minor allele frequency- A:0.26NA EA 240
    rs1487717071,2
    --45669008(+) ATATGC/TTGCAA 1 -- ds50010--------
    rs789503191,2
    C,F--45669063(+) TCATAA/GAAGGA 1 -- ds50011Minor allele frequency- G:0.04NA 120

    HapMap Linkage Disequilibrium report for CHST1 (45670427 - 45687172 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CHST1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1088n71CNV Loss21882294
    esv24804CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CHST1
    DNA2.0 Custom Variant and Variant Library Synthesis for CHST1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603797    OMIM disorders: --

    8 diseases for CHST1:    About MalaCards
    spondyloepiphyseal dysplasia omani type    macular corneal dystrophy    morquio syndrome b    corneal dystrophy
    endotheliitis    atherosclerosis    glioblastoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CHST1:
    Macular corneal dystrophy

    CHST1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CHST1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 1 11310842 (1)

    Genetic Association Database (GAD): CHST1
    Human Genome Epidemiology (HuGE) Navigator: CHST1 (3 documents)

    Export disorders for CHST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHST1 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with CHST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human keratan sulfate Gal- 6-sulfotransferase. (PubMed id 9405439)1, 2, 3, 9 Fukuta M.... Habuchi O. (1997)
    2. Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization. (PubMed id 9639683)1, 2, 3, 9 Mazany K.D.... Williams K.J. (1998)
    3. Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase. (PubMed id 10642612)1, 2, 9 Torii T.... Habuchi O. (2000)
    4. CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. (PubMed id 11310842)1, 2, 9 Li X.... Tedder T.F. (2001)
    5. CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. (PubMed id 10049591)1, 2, 9 Li X. and Tedder T.F. (1999)
    6. Family-Based Analysis of Genetic Variation Underlying Psychosis-Inducing Effects of Cannabis: Sibling Analysis and Proband Follow-up . (PubMed id 21041608)1, 4 van Winkel R. (2010)
    7. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. (PubMed id 10330415)1, 2 Bistrup A.... Hemmerich S. (1999)
    10. L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1. (PubMed id 10528213)1, 9 Tu L....Tedder T.F. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8534 HGNC: 1969 AceView: CHST1 Ensembl:ENSG00000175264 euGenes: HUgn8534
    ECgene: CHST1 Kegg: 8534 H-InvDB: CHST1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHST1 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/chst1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHST1 gene:
    Search GeneIP for patents involving CHST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CHST1 (Carbohydrate Sulfotransferase 1/CHST1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CHST1 (Carbohydrate Sulfotransferase 1/CHST1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CHST1  
     OriGene qPCR primer pairs and template standards for CHST1   OriGene Protein Over-expression Lysate for CHST1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CHST1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHST1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CHST1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHST1   OriGene Custom Protein Services for CHST1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHST1
     QIAGEN SeqTarget long-range PCR primers for resequencing CHST1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHST1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHST1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHST1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHST1
     GenScript Custom Purified and Recombinant Proteins Services for CHST1 GenScript cDNA clones with any tag delivered in your preferred vector for CHST1
     GenScript Custom Assay Services for CHST1 GenScript Custom Superior Antibodies Services for CHST1
     GenScript Custom overexpressing Cell Line Services for CHST1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CHST1 promoter
     Search Chromatin IP Primers for CHST1
     RT2 qPCR Primer Assay in human, mouse, rat CHST1
     Search GNC Networks for CHST1
     SABiosciences PCR Arrays including human, mouse, rat CHST1
     Search Tocris compounds for CHST1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CHST1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CHST1 antibodies
     CHST1 proteins
     CHST1 lysates
     Antibodies for CHST1
     See all of Abcam's Antibodies, Kits and Proteins for CHST1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CHST1
     Antibodies for CHST1
     ELISAs for CHST1
     CLIAs for CHST1
     Search LifeMap BioReagents cell lines for CHST1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHST1
     SwitchGear 3'UTR luciferase reporter plasmids for CHST1
     SwitchGear Promoter luciferase reporter plasmids for CHST1
     Search ThermoFisher Antibodies for CHST1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHST1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CHST1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHST1
    Customized:
     lentivirus for stable overexpression of CHST1
     lentivirus expression plasmids for stable overexpression of CHST1
     adenovirus for overexpression of CHST1
     LSBio Antibodies in human, mouse, rat for CHST1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHST1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4