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CHST1 Gene(Protein Coding)

Carbohydrate Sulfotransferase 1

GCID:
GC11M045647
GIFtS:
57
Genes Participants
UDN Logo

Aliases for CHST1 Gene

Aliases for CHST1 Gene

  • Carbohydrate Sulfotransferase 1 2 3 5
  • Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 1 3 4
  • Carbohydrate (Keratan Sulfate Gal-6) Sulfotransferase 1 2 3
  • Keratan Sulfotransferase 2 3
  • EC 2.8.2.21 4 61
  • KSGal6ST 3 4
  • GST-1 3 4
  • KS6ST 3 4
  • KSST 3 4
  • Carbohydrate (Chondroitin 6/Keratan) Sulfotransferase 1 3
  • Keratan Sulfate Gal-6 Sulfotransferase 4
  • EC 2.8.2 61
  • C6ST 3

External Ids for CHST1 Gene

Previous GeneCards Identifiers for CHST1 Gene

  • GC11M047454
  • GC11M046360
  • GC11M045702
  • GC11M045634
  • GC11M045627
  • GC11M045378
  • GC11M045670

Summaries for CHST1 Gene

Entrez Gene Summary for CHST1 Gene

  • This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST1 Gene

CHST1 (Carbohydrate Sulfotransferase 1) is a Protein Coding gene. Among its related pathways are Keratan sulfate/keratin metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and keratan sulfotransferase activity. An important paralog of this gene is CHST3.

UniProtKB/Swiss-Prot for CHST1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.

Gene Wiki entry for CHST1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST1 Gene

Genomics for CHST1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CHST1 Gene

Enhancers for CHST1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G045339 1.4 Ensembl ENCODE dbSUPER 10.1 +325.5 325456 0.8 HDGF PKNOX1 ATF1 WRNIP1 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF143 CHST1 LOC101928812 SYT13
GH11G045332 1.5 Ensembl ENCODE dbSUPER 9.2 +332.2 332182 2.0 ATF1 FOXA2 YY1 KDM4B SP3 YY2 NFYC ZNF518A MEF2D SMARCA4 PRDM11 SYT13 ENSG00000254497 CHST1 LOC101928812
GH11G045371 1.3 Ensembl ENCODE dbSUPER 10.6 +294.2 294188 0.7 CTCF MXI1 TEAD4 EBF1 ZIC2 RAD21 TEAD3 ZNF664 ZFHX2 SCRT2 LOC101928812 CHST1 LOC399886 ENSG00000254651
GH11G045735 0.8 ENCODE 16.9 -70.9 -70925 1.9 TAF1 MAX CEBPG EBF1 RAD21 YY1 ZFHX2 HNF4G FOS TRIM24 CHST1 ENSG00000255091 SLC35C1 ATG13 PIR58267 PIR52408
GH11G045354 1.2 ENCODE dbSUPER 10.2 +310.1 310122 1.3 HDAC1 CBX3 ATF1 NFIB NFRKB ZNF76 ZBTB40 YY1 ETS1 ETV6 CHST1 ENSG00000254497 LOC105376658 LOC101928812 SYT13 LOC399886
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHST1 on UCSC Golden Path with GeneCards custom track

Promoters for CHST1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039437 256 1201 MXI1 SUZ12 ZIC2 ZNF2 ZFHX2 GLIS2 ZBTB48 POLR2A PATZ1 EGR2

Transcription factor binding sites by QIAGEN in the CHST1 gene promoter:

Genomic Location for CHST1 Gene

Chromosome:
11
Start:
45,647,689 bp from pter
End:
45,665,656 bp from pter
Size:
17,968 bases
Orientation:
Minus strand

Genomic View for CHST1 Gene

Genes around CHST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHST1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CHST1 Gene

Proteins for CHST1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CHST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43916-CHST1_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 1
    Protein Accession:
    O43916
    Secondary Accessions:
    • D3DQP2

    Protein attributes for CHST1 Gene

    Size:
    411 amino acids
    Molecular mass:
    46715 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHST1 Gene

Selected DME Specific Peptides for CHST1 Gene

O43916:
  • ETFRDTYRLWR
  • SIAIQYTAIRTFTAK
  • EDPRLNLKVIQLVRDPRGIL
  • YMLVRYED
  • DVFYLFEPLYHVQ
  • CDLYFLE
  • TGRKPYNLD
  • RSGSSFVGQLF
  • YMLVRYEDLARNP
  • LVEDPRL
  • RRVMLGASRDLLRSLY

Post-translational modifications for CHST1 Gene

  • Glycosylation at posLast=5656, posLast=145145, posLast=189189, and posLast=334334
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CHST1 (Carbohydrate Sulfotransferase 1/CHST1)

Domains & Families for CHST1 Gene

Gene Families for CHST1 Gene

HGNC:

Protein Domains for CHST1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43916

UniProtKB/Swiss-Prot:

CHST1_HUMAN :
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Family:
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
genes like me logo Genes that share domains with CHST1: view

Function for CHST1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CHST1 Gene

GENATLAS Biochemistry:
chondroitin 6-sulfotransferase key enzyme 1,expressed in vascular endothelial cells,implicated in chondrogenesis,neoplasia,atherosclerosis and other
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + keratan = adenosine 3,5-bisphosphate + keratan 6-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.

Enzyme Numbers (IUBMB) for CHST1 Gene

Gene Ontology (GO) - Molecular Function for CHST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity IBA --
GO:0008146 sulfotransferase activity IDA,TAS 10330415
GO:0016740 transferase activity IEA --
GO:0045130 keratan sulfotransferase activity TAS --
genes like me logo Genes that share ontologies with CHST1: view
genes like me logo Genes that share phenotypes with CHST1: view

Animal Models for CHST1 Gene

MGI Knock Outs for CHST1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHST1 Gene

Localization for CHST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHST1 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,NAS 9405439
genes like me logo Genes that share ontologies with CHST1: view

Pathways & Interactions for CHST1 Gene

genes like me logo Genes that share pathways with CHST1: view

Pathways by source for CHST1 Gene

1 BioSystems pathway for CHST1 Gene
1 KEGG pathway for CHST1 Gene
1 R&D Systems pathway for CHST1 Gene

Gene Ontology (GO) - Biological Process for CHST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005976 polysaccharide metabolic process TAS 9405439
GO:0006012 galactose metabolic process IDA 10330415
GO:0006790 sulfur compound metabolic process IDA 10330415
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with CHST1: view

No data available for SIGNOR curated interactions for CHST1 Gene

Drugs & Compounds for CHST1 Gene

Products:

  1. Drug

(1) Drugs for CHST1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for CHST1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
 1053-73-2
Keratan
  • Keratan 6'-sulfate
  • Keratan 6'-sulphate
  • Keratan sulfate
  • Keratan sulphate
  • Kerato 6'-sulfate
 69992-87-6
n-acetyllactosamine
  • beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • beta-D-Galactosyl-1,4-N-acetyl-D-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-beta-delta-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-delta-glucosamine
  • D-Galactopyranosyl
 32181-59-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
 482-67-7
genes like me logo Genes that share compounds with CHST1: view

Transcripts for CHST1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CHST1 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(75) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHST1 Gene

Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST1 Gene

No ASD Table

Relevant External Links for CHST1 Gene

GeneLoc Exon Structure for
CHST1
ECgene alternative splicing isoforms for
CHST1

Expression for CHST1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHST1 Gene

mRNA expression in normal human tissues for CHST1 Gene
mRNA expression by BioGPS for CHST1 GenemRNA expression by GTEx for CHST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST1 Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.6), and Brain - Amygdala (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of CHST1 Gene:

CHST1

SOURCE GeneReport for Unigene cluster for CHST1 Gene:

Hs.104576

mRNA Expression by UniProt/SwissProt for CHST1 Gene:

O43916-CHST1_HUMAN
Tissue specificity: Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes.

Evidence on tissue expression from TISSUES for CHST1 Gene

  • Nervous system(4.6)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with CHST1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHST1 Gene

Orthologs for CHST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CHST1 34 35
  • 99.59 (n)
dog
(Canis familiaris)
 Mammalia CHST1 34 35
  • 93.67 (n)
cow
(Bos Taurus)
 Mammalia CHST1 34 35
  • 92.86 (n)
rat
(Rattus norvegicus)
 Mammalia Chst1 34
  • 87.8 (n)
oppossum
(Monodelphis domestica)
 Mammalia CHST1 35
  • 87 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Chst1 34 16 35
  • 86.67 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CHST1 35
  • 71 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CHST1 34 35
  • 82.4 (n)
lizard
(Anolis carolinensis)
 Reptilia CHST1 35
  • 81 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia chst1 34
  • 66.26 (n)
zebrafish
(Danio rerio)
 Actinopterygii chst1 34 35
  • 66.99 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG9550 35
  • 20 (a)
 ManyToMany
CG31637 35
  • 18 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 37 (a)
 ManyToMany
-- 35
  • 30 (a)
 ManyToMany
-- 35
  • 27 (a)
 ManyToMany
-- 35
  • 24 (a)
 ManyToMany
-- 35
  • 24 (a)
 ManyToMany
-- 35
  • 22 (a)
 ManyToMany
-- 35
  • 21 (a)
 ManyToMany
CSA.5535 35
  • 21 (a)
 ManyToMany
Species where no ortholog for CHST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST1 Gene

ENSEMBL:
Gene Tree for CHST1 (if available)
TreeFam:
Gene Tree for CHST1 (if available)

Paralogs for CHST1 Gene

Paralogs for CHST1 Gene

(4) SIMAP similar genes for CHST1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHST1: view

Variants for CHST1 Gene

Sequence variations from dbSNP and Humsavar for CHST1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000103267 -- 45,667,408(+) TACCA(A/C)GTCTG upstream-variant-2KB
rs1000256847 -- 45,661,489(+) GAGAG(C/T)TGGCA intron-variant
rs1000484296 -- 45,667,074(+) TGTTG(C/T)GTTCA upstream-variant-2KB
rs1000594521 -- 45,662,708(+) TCGGT(A/G)TTATT intron-variant
rs1000627076 -- 45,662,942(+) AAGTC(A/C)CGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST1 Gene

Variant ID Type Subtype PubMed ID
esv24804 CNV loss 19812545
nsv554197 CNV loss 21841781
nsv554198 CNV loss 21841781
nsv554199 CNV loss 21841781

Variation tolerance for CHST1 Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHST1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST1 Gene

Disorders for CHST1 Gene

Relevant External Links for CHST1

Genetic Association Database (GAD)
CHST1
Human Genome Epidemiology (HuGE) Navigator
CHST1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHST1

No disorders were found for CHST1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHST1 Gene

Publications for CHST1 Gene

  1. Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization. (PMID: 9639683) Mazany K.D. … Williams K.J. (Biochim. Biophys. Acta 1998) 2 3 4 22 64
  2. Molecular cloning and characterization of human keratan sulfate Gal- 6-sulfotransferase. (PMID: 9405439) Fukuta M. … Habuchi O. (J. Biol. Chem. 1997) 2 3 4 22 64
  3. CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. (PMID: 11310842) Li X. … Tedder T.F. (J. Leukoc. Biol. 2001) 3 4 22 64
  4. Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase. (PMID: 10642612) Torii T. … Habuchi O. (Glycobiology 2000) 3 4 22 64
  5. CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. (PMID: 10049591) Li X. … Tedder T.F. (Genomics 1999) 3 4 22 64

Products for CHST1 Gene

Sources for CHST1 Gene

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