CHRNB3 Gene
protein-coding GIFtS: 62
GCID: GC08P042552
|
|
cholinergic receptor, nicotinic, beta 3 (neuronal)(Previous names: cholinergic receptor, nicotinic, beta polypeptide 3 )
| |
Aliases
for CHRNB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cholinergic Receptor, Nicotinic, Beta 3 (Neuronal)1 2 | | Cholinergic Receptor, Nicotinic, Beta Polypeptide 31 2 | | Acetylcholine Receptor, Neuronal Nicotinic, Beta-3 Subunit2 | | Acetylcholine Receptor, Nicotinic, Beta 3 (Neuronal)2 | | Neuronal Acetylcholine Receptor Subunit Beta-32 |
Export aliases for CHRNB3 gene to outside databasesPrevious GC identifers: GC08P042340 GC08P042622 GC08P042569 GC08P042671 GC08P041074 |
Summaries
for CHRNB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHRNB3:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediatefast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunitsthat make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primarystructure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arrangedaround the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have apair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteineresidues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 (PubMed 9009220)). Elliott et al. (1996)(PubMed 8906617) stated that the proposed structure for each subunit is a conserved N-terminal extracellular domainfollowed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain,and a short C-terminal extracellular region.(supplied by OMIM, Apr 2010)
UniProtKB/Swiss-Prot: ACHB3_HUMAN, Q05901Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects allsubunits and leads to opening of an ion-conducting channel across the plasma membrane
 summary
for CHRNB3: Nicotinic receptors (nAChRs) are ligand-gated ion channels that modulate cell membrane potentials. Each
receptor is composed of pentameric combinations of subunits (alpha1-10, beta1-4, delta, epsilon and gamma).
Nicotinic receptors are generally divided into three functional classes: muscle subunits (alpha1, beta1,
delta, epsilon, gamma), standard neuronal subunits (alpha1-6 and beta2-4) that form in pairwise alphabeta
combinations, and subunits (alpha7-9) that can form homomeric nAChRs. Neuronal nicotinic receptors are found
in the central nervous system and in autonomic ganglia where they regulate processes such as transmitter
release, cell excitability and neuronal integration. Nicotinic receptors located at the neuromuscular
junctions of somatic muscles are responsible for muscular contraction.
Gene Wiki entry for CHRNB3
|
Genomic Views
for CHRNB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHRNB3 gene promoter:
ER-alpha Pbx1a Meis-1b AREB6 Nkx6-1 IRF-7A Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHRNB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRNB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p11.2 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p11.21CHRNB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P042552: view genomic region
(about GC identifiers)
Start:
|
42,552,519 bp from pter |
End:
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42,592,550 bp from pter |
Size:
|
40,032 bases |
Orientation:
|
plus strand |
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Proteins
for CHRNB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACHB3_HUMAN, Q05901 (See
protein sequence)Recommended Name: Neuronal acetylcholine receptor subunit beta-3 precursor Size: 458 amino acids; 52729 Da
Subunit: Neuronal AChR seems to be composed of two different type of subunits: alpha and beta
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane;Multi-pass membrane protein
Secondary accessions: Q15827Explore the universe of human proteins at neXtProt for CHRNB3: NX_Q05901
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q05901
CHRNB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000740.1
ENSEMBL proteins: ENSP00000433913 ENSP00000289957 Reactome Protein details: Q05901
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
CHRNB3 for ontologies About GeneDecksing
CHRNB3 Antibody Products:
Assay Products for CHRNB3: |
Protein
Domains /
Families
for CHRNB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHRNB3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q05901ProtoNet protein and cluster: Q05901 2 Blocks protein families: IPB002394 Nicotinic acetylcholine receptor signature IPB006201 Neurotransmitter-gated ion-channel
UniProtKB/Swiss-Prot: ACHB3_HUMAN, Q05901Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.Beta-3/CHRNB3 sub-subfamily |
Function
for CHRNB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ACHB3_HUMAN, Q05901Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects allsubunits and leads to opening of an ion-conducting channel across the plasma membrane Genatlas biochemistry entry for CHRNB3:cholinergic receptor,nicotinic,beta 3 polypeptide,neuronal
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CHRNB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNB3 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CHRNB3 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Chrnb3):
CHRNB3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CHRNB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Presynaptic nicotinic acetylcholine receptors | | | 2 | Transmission across Chemical Synapses | | | 3 | Sympathetic Nerve Pathway (Neuroeffector Junction) | | | 4 | Calcium channels | | | 5 | Nanog in Mammalian ESC Pluripotency | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CHRNB3
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CHRNB3
5/9 
Reactome Pathways for CHRNB3 (see all 9)
1  PharmGKB Pathway for CHRNB3
1 
Kegg Pathway (Kegg details for CHRNB3):
CHRNB3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHRNB3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/15 Interacting proteins for CHRNB3 (ENSP000002899574) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CHRNB3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHRNB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for CHRNB3 available from Tocris Bioscience About this table
2 DrugBank Compounds for CHRNB3 About this table
Search CenterWatch for drugs/clinical trials and news about CHRNB3 / ACHB3
|
Transcripts
for CHRNB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHRNB3 gene: NM_000749.3 Unigene Cluster for CHRNB3: Cholinergic receptor, nicotinic, beta 3 (neuronal) Hs.654576 [show with all ESTs]Unigene Representative Sequence: NM_0007493 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531610 ENST00000534391 ENST00000289957(uc003xpi.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHRNB3 (NM_000749) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHRNB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNB3 |
Additional cDNA sequence: BC069681.1 BC069703.1 BC069788.1 U62438.1 X67513.1 Y08417.1 3 DOTS entries: DT.106884 DT.95106800 DT.121468223 12 AceView cDNA sequences: BM682965 Y08417 BM718981 BC069788 BM698366 BC069703 NM_000749 BC069681 U62438 D38695 X67513 BU736120
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CHRNB3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CHRNB3
|
Expression
for CHRNB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHRNB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAGAAAGA
About this image
See CHRNB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHRNB3
SOURCE GeneReport for Unigene cluster: Hs.654576
SABiosciences Custom PCR Arrays for CHRNB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRNB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHRNB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRNB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNB3 |
Orthologs
for CHRNB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CHRNB3 gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CHRNB31 |
cholinergic receptor, nicotinic, beta 3 |
75.19(n)
85.33(a) |
|
395604 NM_204812.1 NP_990143.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CHRNB36 |
-- |
83(a) |
1 ↔ 1 |
GL343339.1(785244-802706) |
African clawed frog
(Xenopus laevis) |
Amphibia |
chrnb3-prov2 |
cholinergic receptor, nicotinic, beta polypeptide 3 |
79.36(n) |
|
BC054966.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AB087185.12 |
-- |
75.61(n) |
|
317643 AB087185.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
nAcRalpha-96Aa3 |
nicotinic acetylcholine-activated
cation-selective more |
53(a)
(best of 6) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-633 |
ion-channel protein |
44(a)
(best of 12) |
|
I(5141683-5149120) -- |
ENSEMBL Gene Tree for CHRNB3 (if available)
TreeFam Gene Tree for CHRNB3 (if available) |
Paralogs
for CHRNB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHRNB3 gene
- CHRNA52 CHRNA22 CHRNA12 CHRNA62 CHRNA72 CHRNE2 CHRNB42 CHRNA42
- CHRNA102 CHRNA92 CHRNB22 CHRNG2 CHRNA32 CHRFAM7A2 CHRNB12 CHRND2
18 SIMAP similar genes for CHRNB3 using alignment to 1 protein entry: ACHB3_HUMAN:CHRNA5 CHRNA4 CHRNA1 CHRNA6 CHRNA2 CHRNB4
CHRNA3 CHRNA7-2 CHRNB2 CHRNA10 CHRNA9 CHRNE
CHRND CHRNB1 CHRNG CHRNA7 HTR3A HTR3B
CHRNB3 for paralogs About GeneDecksing
|
Genomic Variants
for CHRNB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHRNB3 (42552519 - 42592550 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CHRNB3
2 Indels: 41080 13052
Human Gene Mutation Database (HGMD): CHRNB3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHRNB3 |
|
Disorders
/ Diseases
for CHRNB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHRNB3 for disorders About GeneDecksing
OMIM gene information: 118508
OMIM disorders: --
10  diseases for CHRNB3: About MalaCardsautosomal dominant nocturnal frontal lobe epilepsy neuronitis frontal lobe epilepsy juvenile absence epilepsy
absence epilepsy nicotine dependence bipolar disorder pharyngitis
lung cancer alcoholism
3 diseases from the University of Copenhagen DISEASES database for CHRNB3:Nicotine dependence Juvenile absence epilepsy Epilepsy with generalized tonic-clonic seizures Genetic Association Database (GAD): CHRNB3
Human Genome Epidemiology (HuGE) Navigator: CHRNB3 (24 documents)
Export disorders for CHRNB3 gene to outside databases
|
Publications
for CHRNB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHRNB3 gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with CHRNB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. (PubMed id 16314871)1, 4 Greenbaum L....Lerer B. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. (PubMed id 9009220)1, 2 Groot Kormelink P.J. and Luyten W.H.M.L. (1997)
- Comparative structure of human neuronal alpha 2-alpha 7 and beta 2- beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. (PubMed id 8906617)1, 2 Elliott K.J.... Harpold M.M. (1996)
- Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit. (PubMed id 7690916)1, 2 Willoughby J.J.... Wood J.N. (1993)
- Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans. (PubMed id 1505988)1, 3 Anand R. and Lindstrom J. (1992)
- Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and n icotine dependence. (PubMed id 19482438)1, 9 Etter J.F....Bertrand D. (2009)
- CHRNB3 is more strongly associated with Fagerstrom tes t for cigarette dependence-based nicotine dependence than cigarettes per day: ph enotype definition changes genome-wide association studies results. (PubMed id 22524403)1 Rice J.P....Bierut L.J. (2012)
- Modulation of gain-of-function a6*-nicotinic acetylcho line receptor by b3 subunits. (PubMed id 22315221)1 Dash B. and Lukas R.J. (2012)
- [Human chromosome 8p11 (CHRNB3-CHRNA6) region gene po lymorphisms and susceptibility to lung cancer in Chinese Han population]. (PubMed id 21831805)1 Zhang X.B....Lu D.R. (2011)
|
External Searches for CHRNB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHRNB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHRNB3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHRNB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHRNB3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CHRNB3 gene:
Search GeneIP for patents involving CHRNB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHRNB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CHRNB3 | | OriGene shRNA RFP for CHRNB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHRNB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRNB3 | | | OriGene Protein Over-expression Lysate for CHRNB3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHRNB3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHRNB3 | | OriGene Custom Protein Services for CHRNB3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHRNB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHRNB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRNB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRNB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRNB3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNB3 |
|  |  |  | | | | ThermoFisher Antibodies for CHRNB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNB3 |
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