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CHRNB3 Gene

protein-coding   GIFtS: 63
GCID: GC08P042552

Cholinergic Receptor, Nicotinic, Beta 3 (Neuronal)

(Previous names: cholinergic receptor, nicotinic, beta polypeptide 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cholinergic Receptor, Nicotinic, Beta 3 (Neuronal)1 2     nicotinic1
Cholinergic Receptor, Nicotinic, Beta Polypeptide 31 2     Acetylcholine Receptor, Neuronal Nicotinic, Beta-3 Subunit2
Acetylcholine Receptor1     Acetylcholine Receptor, Nicotinic, Beta 3 (Neuronal)2
Beta 3 (Neuronal)1     Neuronal Acetylcholine Receptor Subunit Beta-32

External Ids:    HGNC: 19631   Entrez Gene: 11422   Ensembl: ENSG000001474327   OMIM: 1185085   UniProtKB: Q059013   

Export aliases for CHRNB3 gene to outside databases

Previous GC identifers: GC08P042340 GC08P042622 GC08P042569 GC08P042671 GC08P041074


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHRNB3 Gene:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that
mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits.
The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have
different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous
subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1
(MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits
lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 (PubMed
9009220)). Elliott et al. (1996) (PubMed 8906617) stated that the proposed structure for each subunit is a
conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic
loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.(supplied by OMIM, Apr
2010)

GeneCards Summary for CHRNB3 Gene:
CHRNB3 (cholinergic receptor, nicotinic, beta 3 (neuronal)) is a protein-coding gene. Diseases associated with CHRNB3 include epilepsy with generalized tonic-clonic seizures, and juvenile absence epilepsy. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and acetylcholine binding. An important paralog of this gene is CHRNA4.

UniProtKB/Swiss-Prot: ACHB3_HUMAN, Q05901
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all
subunits and leads to opening of an ion-conducting channel across the plasma membrane

Gene Wiki entry for CHRNB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHRNB3 gene promoter:
         ER-alpha   Pbx1a   Meis-1b   AREB6   Nkx6-1   IRF-7A   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRNB3 promoter sequence
   Search Chromatin IP Primers for CHRNB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRNB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.21

CHRNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRNB3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P042552:  view genomic region     (about GC identifiers)

Start:
42,552,519 bp from pter      End:
42,592,550 bp from pter
Size:
40,032 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACHB3_HUMAN, Q05901 (See protein sequence)
Recommended Name: Neuronal acetylcholine receptor subunit beta-3 precursor  
Size: 458 amino acids; 52729 Da
Subunit: Neuronal AChR seems to be composed of two different type of subunits: alpha and beta
Secondary accessions: Q15827

Explore the universe of human proteins at neXtProt for CHRNB3: NX_Q05901

Explore proteomics data for CHRNB3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn51, Asn138, Asn166

  • See CHRNB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000740.1  
    ENSEMBL proteins: 
     ENSP00000433913   ENSP00000289957  
    Reactome Protein details: Q05901

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHRN: Ligand-gated ion channels / Acetylcholine receptors, nicotinic
    CHR: Cholinergic receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: beta3
    Nicotinic acetylcholine receptors

    Selected InterPro protein domains (see all 6):
     IPR027361 Acetylcholine_rcpt_TM
     IPR002394 Nicotinic_acetylcholine_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry Q05901

    ProtoNet protein and cluster: Q05901

    2 Blocks protein domains:
    IPB002394 Nicotinic acetylcholine receptor signature
    IPB006201 Neurotransmitter-gated ion-channel


    UniProtKB/Swiss-Prot: ACHB3_HUMAN, Q05901
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1)
    subfamily. Beta-3/CHRNB3 sub-subfamily


    CHRNB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACHB3_HUMAN, Q05901
    Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all
    subunits and leads to opening of an ion-conducting channel across the plasma membrane

         Genatlas biochemistry entry for CHRNB3:
    cholinergic receptor,nicotinic,beta 3 polypeptide,neuronal

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004889acetylcholine-activated cation-selective channel activity IEA--
    GO:0005230extracellular ligand-gated ion channel activity ----
    GO:0008144drug binding IEA--
    GO:0015267channel activity TAS7690916
    GO:0042166acetylcholine binding IEA--
         
    CHRNB3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Chrnb3):
     behavior/neurological 

    CHRNB3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHRNB3
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACHB3_HUMAN, Q05901: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005892acetylcholine-gated channel complex IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS8906617
    GO:0030054cell junction IEA--

    CHRNB3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHRNB3 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of Nicotinic Acetylcholine Receptors
    Activation of Nicotinic Acetylcholine Receptors
    Acetylcholine Binding And Downstream Events0.00
    Presynaptic nicotinic acetylcholine receptors0.00
    Highly calcium permeable postsynaptic nicotinic acetylcholine receptors0.00
    Highly calcium permeable nicotinic acetylcholine receptors0.00
    Postsynaptic nicotinic acetylcholine receptors0.00
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    3Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    4Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    5Calcium channels
    Calcium channels

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CHRNB3
        eNOS Signaling


    2 Reactome Pathways for CHRNB3
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
    Highly calcium permeable nicotinic acetylcholine receptors


    1 Kegg Pathway  (Kegg details for CHRNB3):
        Neuroactive ligand-receptor interaction


    CHRNB3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHRNB3
    Interactions:

        GeneGlobe Interaction Network for CHRNB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for CHRNB3 (ENSP000002899574) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRNA2ENSP000002401324STRING: ENSP00000240132
    CHRNA3ENSP000003156024STRING: ENSP00000315602
    CHRNA4ENSP000003592854STRING: ENSP00000359285
    CHRNA5ENSP000002995654STRING: ENSP00000299565
    CHRNA6ENSP000002764104STRING: ENSP00000276410
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7690916
    GO:0006811ion transport ----
    GO:0006812cation transport TAS7690916
    GO:0007165signal transduction TAS7690916
    GO:0007268synaptic transmission TAS--

    CHRNB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CHRNB3 (ACHB3)

    2 DrugBank Compounds for CHRNB3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Galantamine(-)-Galanthamine (see all 3)357-70-0targetallosteric modulator12137632 11129124 12481195 20480924 12177686 10971048
    NicotineL-Nicotine (see all 2)54-11-5targetagonist19560048 20081230 20400469 11006350



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHRNB3 gene: 
    NM_000749.3  

    Unigene Cluster for CHRNB3:

    Cholinergic receptor, nicotinic, beta 3 (neuronal)
    Hs.654576  [show with all ESTs]
    Unigene Representative Sequence: NM_000749
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531610 ENST00000534391 ENST00000289957(uc003xpi.1)
    miRNA
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    hsa-miR-2116*
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    Additional mRNA sequence: 

    BC069681.1 BC069703.1 BC069788.1 U62438.1 X67513.1 Y08417.1 

    3 DOTS entries:

    DT.106884  DT.95106800  DT.121468223 

    12 AceView cDNA sequences:

    BM682965 Y08417 BC069788 BM718981 BC069703 BM698366 U62438 BC069681 
    NM_000749 D38695 X67513 BU736120 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CHRNB3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:              -     -                                       
    SP2:                                                            
    SP3:              -                                             


    ECgene alternative splicing isoforms for CHRNB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHRNB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGAAAGA
    CHRNB3 Expression
    About this image


    CHRNB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Thalamus
             Substantia Nigra   
     
     Neural Tube (Nervous System)
             brain/midbrain/lateral wall   
    CHRNB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHRNB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654576
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CHRNB3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrnb31 , 5 cholinergic receptor, nicotinic, beta polypeptide 31, 5 81.98(n)1
    88.69(a)1
      8 (16.00 cM)5
    1080431  NM_173212.41  NP_775304.11 
     273687115 
    chicken
    (Gallus gallus)
    Aves CHRNB31 cholinergic receptor, nicotinic, beta 3 (neuronal) 75.19(n)
    85.33(a)
      395604  NM_204812.1  NP_990143.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHRNB36
    cholinergic receptor, nicotinic, beta 3 (neuronal)...
    86(a)
    1 ↔ 1
    GL343339.1(781091-815826)
    African clawed frog
    (Xenopus laevis)
    Amphibia chrnb3-prov2 cholinergic receptor, nicotinic, beta polypeptide 3 79.36(n)    BC054966.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB087185.12   -- 75.61(n)   317643  AB087185.1 


    ENSEMBL Gene Tree for CHRNB3 (if available)
    TreeFam Gene Tree for CHRNB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CHRNB3 gene
    CHRNA42  CHRNA52  CHRNA22  CHRNA12  CHRNB22  CHRNA62  CHRNG2  CHRNA32  
    CHRNE2  CHRND2  CHRNB12  CHRNB42  
    18 SIMAP similar genes for CHRNB3 using alignment to 1 protein entry:     ACHB3_HUMAN:
    CHRNA5    CHRNA4    CHRNA1    CHRNA6    CHRNA2    CHRNB4
    CHRNA3    CHRNA7-2    CHRNB2    CHRNA10    CHRNA9    CHRNE
    CHRND    CHRNB1    CHRNG    CHRNA7    HTR3A    HTR3B

    CHRNB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHRNB3 (see all 973)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1926004371,2
    --42550599(+) GGCTGC/TAAAGT 1 -- us2k10--------
    rs758020841,2
    F--42550666(+) CAGGAC/TCGTGC 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1831264661,2
    --42550716(+) GGCCAC/GGGTTG 1 -- us2k10--------
    rs1176347941,2
    C,F--42550864(+) CATGGA/CCCCCA 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1867499951,2
    --42550873(+) CAGCTC/GTGGTC 1 -- us2k10--------
    rs1409777651,2
    --42551019(+) GGCTAC/GCTTCA 1 -- us2k10--------
    rs64744131,2
    C,F,A,H--42551064(+) TCCTGT/CACACT 1 -- us2k127Minor allele frequency- C:0.35EA NA NS WA CSA 3420
    rs1448165771,2
    --42551132(+) AGCACA/TGTTGA 1 -- us2k10--------
    rs70043811,2
    C,F,A,H--42551161(+) AGTGCG/ATGGCT 1 -- us2k124Minor allele frequency- A:0.37NS EA NA WA CSA 2354
    rs69850521,2
    C,F,A,H--42551319(+) GGCAGT/CGACAT 1 -- us2k111Minor allele frequency- C:0.38NA WA CSA EA 374

    HapMap Linkage Disequilibrium report for CHRNB3 (42552519 - 42592550 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CHRNB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662041CNV Deletion23128226
    esv2668251CNV Deletion23128226
    esv2666038CNV Deletion23128226
    nsv397520CNV Loss16902084

    Human Gene Mutation Database (HGMD): CHRNB3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHRNB3
    DNA2.0 Custom Variant and Variant Library Synthesis for CHRNB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118508    OMIM disorders: --

    11 diseases for CHRNB3:    
    About MalaCards
    epilepsy with generalized tonic-clonic seizures    juvenile absence epilepsy    nicotine dependence    autosomal dominant nocturnal frontal lobe epilepsy
    frontal lobe epilepsy    neuronitis    nicotine addiction    bipolar disorder
    alcohol dependence    neuroblastoma    lung cancer

    3 diseases from the University of Copenhagen DISEASES database for CHRNB3:
    Nicotine dependence     Juvenile absence epilepsy     Epilepsy with generalized tonic-clonic seizures

    CHRNB3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHRNB3
    Human Genome Epidemiology (HuGE) Navigator: CHRNB3 (24 documents)

    Export disorders for CHRNB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHRNB3 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with CHRNB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence. (PubMed id 19482438)1, 4, 9 Etter J.F....Bertrand D. (Addict Behav 2009)
    2. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. (PubMed id 20418888)1, 4 Thorgeirsson T.E....Stefansson K. (Nat. Genet. 2010)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. Association of CHRN genes with &quot;dizziness&quot; to tobacco. (PubMed id 19760673)1, 4 Ehringer M.A....Bierut L.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (PubMed id 20584212)1, 4 Saccone N.L....Bierut L.J. (Genes Brain Behav. 2010)
    6. Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the FagerstrAPm test for nicotine dependence. (PubMed id 20736995)1, 4 Wessel J....Bergen A.W. (Neuropsychopharmacology 2010)
    7. SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample. (PubMed id 19500157)1, 4 Hoft N.R....Ehringer M.A. (Genes Brain Behav. 2009)
    8. Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample. (PubMed id 18704094)1, 4 Hoft N.R....Ehringer M.A. (Neuropsychopharmacology 2009)
    9. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. (PubMed id 19259974)1, 4 Saccone N.L....Bierut L.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1142 HGNC: 1963 AceView: CHRNB3 Ensembl:ENSG00000147432 euGenes: HUgn1142
    ECgene: CHRNB3 Kegg: 1142 H-InvDB: CHRNB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CHRNB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CHRNB3 gene:
    Search GeneIP for patents involving CHRNB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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