CHRNB2 Gene
protein-coding GIFtS: 62
GCID: GC01P154540
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|
cholinergic receptor, nicotinic, beta 2 (neuronal)(Previous names: cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)...)
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Aliases
for CHRNB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cholinergic Receptor, Nicotinic, Beta 2 (Neuronal)1 2 | | NAChRB21 | | Cholinergic Receptor, Nicotinic, Beta Polypeptide 2 (Neuronal)1 2 | | Neuronal Acetylcholine Receptor Subunit Beta-22 | | EFNL32 5 | | Neuronal Nicotinic Acetylcholine Receptor Beta 22 | | Acetylcholine Receptor, Nicotinic, Beta 2 (Neuronal)2 | | |
Export aliases for CHRNB2 gene to outside databasesPrevious GC identifers: GC01P152356 GC01P150271 GC01P151315 GC01P151758 GC01P151759 GC01P151353 GC01P152806 GC01P125903 |
Summaries
for CHRNB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHRNB2:
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and betasubunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassiumacross the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of severalbeta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ACHB2_HUMAN, P17787Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects allsubunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions
 summary
for CHRNB2: Nicotinic alpha4beta2 receptors have high affinity for nicotine and account for >90% of [3H]-nicotine
binding to brain tissues. A stoichiometry of (alpha4)2(beta2)3 has been proposed, generating two agonist
binding sites consistent with the model of the muscle nAChR. Manipulation of the stoichiometry of
alpha4beta2 nAChRs expressed in Xenopus oocytes indicates that (alpha4)3(beta2)2 nAChRs are also viable,
displaying lower affinity for ACh and higher Ca2+ permeability; whether native nAChRs with this subunit
stoichiometry exist is not known. Transgenic knockout of either of these subunits eliminates nicotine self
administration, whereas virally targeted re-expression of the beta2 subunit in mesolimbic areas of beta2
knockout mice recovers this behavior, implicating a role for alpha4beta2 nAChRs in nicotine addiction.
alpha4beta2 nAChRs are highly expressed in the thalamus and have been suggested to have a putative role in
the thalamo-cortical circuitry . As a consequence of their putative role in thalamo-cortical circuitry, gain
of function mutations in the M2 domain of either the alpha4 or beta2 subunit give rise to some forms of
autosomal dominant nocturnal frontal lobe epilepsy. The human genes encoding the nicotinic alpha4 and beta2
receptor subunits have been localized to chromosomes 13 (q13.2-q13.3) and 1 (1q21.3) respectively.
Gene Wiki entry for CHRNB2
|
Genomic Views
for CHRNB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHRNB2 gene promoter:
AhR Egr-3 HOXA3 NRSF form 1 CUTL1 NRSF form 2 Evi-1 GATA-2 Arnt ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHRNB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRNB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3CHRNB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P154540: view genomic region
(about GC identifiers)
Start:
|
154,540,257 bp from pter |
End:
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154,552,502 bp from pter |
Size:
|
12,246 bases |
Orientation:
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plus strand |
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Proteins
for CHRNB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACHB2_HUMAN, P17787 (See
protein sequence)Recommended Name: Neuronal acetylcholine receptor subunit beta-2 precursor Size: 502 amino acids; 57019 Da
Subunit: Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combinedto alpha-2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers.Interacts with RIC3; which is required for proper folding and assembly
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane;Multi-pass membrane protein
5 PDB 3D structures from  and Proteopedia  for CHRNB2:2GVT (3D)
2K58 (3D)
2K59 (3D)
2KSR (3D)
2LM2 (3D)
Secondary accessions: Q9UEH9Explore the universe of human proteins at neXtProt for CHRNB2: NX_P17787
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17787
CHRNB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000739.1
ENSEMBL proteins: ENSP00000357461 Reactome Protein details: P17787
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CHRNB2 for ontologies About GeneDecksing
CHRNB2 Antibody Products:
Assay Products for CHRNB2: |
Protein
Domains /
Families
for CHRNB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHRNB2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17787ProtoNet protein and cluster: P17787 2 Blocks protein families: IPB002394 Nicotinic acetylcholine receptor signature IPB006201 Neurotransmitter-gated ion-channel
UniProtKB/Swiss-Prot: ACHB2_HUMAN, P17787Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.Beta-2/CHRNB2 sub-subfamily |
Function
for CHRNB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ACHB2_HUMAN, P17787Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects allsubunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions Genatlas biochemistry entry for CHRNB2:cholinergic receptor,nicotinic,beta 2 polypeptide,neuronal
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHRNB2 (NM_000748) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHRNB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNB2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNB2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
CHRNB2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Chrnb2tm1Mdb for CHRNB2
15/17 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Chrnb2) (see all 17):
CHRNB2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CHRNB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Presynaptic nicotinic acetylcholine receptors | | | 2 | Transmission across Chemical Synapses | | | 3 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | | | 4 | Calcium channels | | | 5 | SIDS Susceptibility Pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CHRNB2
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CHRNB2
2  BioSystems Pathways for CHRNB2
5/10 
Reactome Pathways for CHRNB2 (see all 10)
1  PharmGKB Pathway for CHRNB2
2 
Kegg Pathways (Kegg details for CHRNB2):
CHRNB2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHRNB2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/18 Interacting proteins for CHRNB2 (P177873 ENSP000003574614) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5/44 biological process terms (GO ID links to tree view) (see all 44): About this table
CHRNB2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHRNB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CHRNB2 for compounds About GeneDecksing
Compounds for CHRNB2 available from Tocris Bioscience About this table
2 DrugBank Compounds for CHRNB2 About this table
4 Novoseek chemical compound relationships for CHRNB2 gene About this table
Search CenterWatch for drugs/clinical trials and news about CHRNB2 / ACHB2
|
Transcripts
for CHRNB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHRNB2 gene: NM_000748.2 Unigene Cluster for CHRNB2: Cholinergic receptor, nicotinic, beta 2 (neuronal) Hs.2306 [show with all ESTs]Unigene Representative Sequence: NM_0007481 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000368476(uc001ffg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHRNB2 (NM_000748) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHRNB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNB2 |
Additional cDNA sequence: AK313470.1 BC075040.2 BC075041.2 U62437.1 X53179.1 Y08415.1 1 DOTS entry: DT.100752185 24/42 AceView cDNA sequences (see all 42): BC075040 BE796482 X53179 F12988 NM_000748 U62437 BE796758 BQ071347 BQ719128 BX951882 Y08415 BC075041 BX283415 AI808724 BG472114 BX493862 BX505019 AI263160 C05589 AL712090 BF528224 BE261002 BG820708 AA211404
GeneLoc Exon Structure
|
Expression
for CHRNB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHRNB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTTGTCTTT
About this image
See CHRNB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHRNB2
SOURCE GeneReport for Unigene cluster: Hs.2306
SABiosciences Expression via Pathway-Focused PCR Array including CHRNB2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRNB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHRNB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRNB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNB2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNB2 |
Orthologs
for CHRNB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CHRNB2 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CHRNB21 |
cholinergic receptor, nicotinic, beta 2 (neuronal) |
82.76(n)
88.25(a) |
|
395605 NM_204813.1 NP_990144.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CHRNB26 |
-- |
82(a) |
1 ↔ 1 |
GL344076.1(74115-84434) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1005377131 |
neuronal acetylcholine receptor subunit beta-2-like |
75.29(n)
83.64(a) |
|
100537713 XM_003200183.1 XP_003200231.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
nAcRalpha-7E3 |
nicotinic acetylcholine-activated
cation-selective more |
53(a)
(best of 7) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
acr-23 |
nicotinic acetylcholine receptor subunit |
48(a)
(best of 20) |
|
X(6737955-6744405) -- |
ENSEMBL Gene Tree for CHRNB2 (if available)
TreeFam Gene Tree for CHRNB2 (if available) |
Paralogs
for CHRNB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHRNB2 gene
- CHRNA52 CHRNA22 CHRNA12 CHRNA62 CHRNA72 CHRNE2 CHRNB42 CHRNA42
- CHRNA102 CHRNA92 CHRNG2 CHRNA32 CHRFAM7A2 CHRNB12 CHRNB32 CHRND2
17 SIMAP similar genes for CHRNB2 using alignment to 2 protein entries: ACHB2_HUMAN (see all proteins):CHRNB4 CHRNA6 CHRNA7-2 CHRNA3 CHRNA2 CHRNB3
CHRNA1 CHRNA5 CHRNA7 CHRNA9 CHRFAM7A CHRND
CHRNE CHRNA10 CHRNB1 CHRNG HTR3A
CHRNB2 for paralogs About GeneDecksing
|
Genomic Variants
for CHRNB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHRNB2 (154540257 - 154552502 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHRNB2: --
Human Gene Mutation Database (HGMD): CHRNB2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHRNB2 |
|
Disorders
/ Diseases
for CHRNB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHRNB2 for disorders About GeneDecksing
OMIM gene information: 118507
OMIM disorders: 605375
UniProtKB/Swiss-Prot: ACHB2_HUMAN, P17787
Defects in CHRNB2 are the cause of nocturnal frontal lobe epilepsy type 3 (ENFL3) [MIM:605375]. ENFL3 is anautosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organizedstereotyped movements
19  diseases for CHRNB2: About MalaCardsautosomal dominant nocturnal frontal lobe epilepsy frontal lobe epilepsy epilepsy, nocturnal frontal lobe, 3 neuronitis
nicotine addiction idiopathic generalized epilepsy generalized epilepsy nicotine dependence
febrile seizures seizures pandas alzheimer's disease
down syndrome schizophrenia dementia cerebritis
hypoxia memory impairment alcoholism
3 diseases from the University of Copenhagen DISEASES database for CHRNB2:Nicotine dependence Focal epilepsy Early onset absence epilepsy 7 Novoseek disease relationships for CHRNB2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| epilepsy frontal lobe |
94.2 |
14 |
11952766 (2), 17900292 (2), 17602836 (1), 18534914 (1) (see all 11) |
| seizures febrile |
55.9 |
2 |
19853223 (1), 11579435 (1) |
| epilepsy |
53.9 |
4 |
15964197 (1), 17385675 (1), 19853223 (1), 11579435 (1) |
| epilepsy generalized |
53.7 |
1 |
11579435 (1) |
| smoking habit |
53.7 |
5 |
11054772 (2), 15154117 (1), 11906688 (1), 15790597 (1) |
| alzheimers disease |
29.9 |
1 |
17192785 (1) |
| schizophrenia |
27.5 |
3 |
18762859 (3) |
GeneTests: CHRNB2
Nocturnal Frontal Lobe Epilepsy, Autosomal Dominant
Genetic Association Database (GAD): CHRNB2
Human Genome Epidemiology (HuGE) Navigator: CHRNB2 (42 documents)
Export disorders for CHRNB2 gene to outside databases
|
Publications
for CHRNB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHRNB2 gene, integrated from 9 sources (see all 120):
(articles sorted by number of sources associating them with CHRNB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2). (PubMed id 11906688)1, 2, 4, 9 Lueders K.K....Hamer D.H. (2002)
- The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3). (PubMed id 9921897)1, 2, 9 Rempel N.... Steinlein O.K. (1998)
- Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence. (PubMed id 11054772)1, 4, 9 Silverman M.A....Straub R.E. (2000)
- Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease. (PubMed id 12214130)1, 4, 9 Kawamata J. and Shimohama S. (2002)
- Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes. (PubMed id 10441742)1, 2, 9 Lueders K.K....Hamer D. (1999)
- Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. (PubMed id 16636791)1, 7, 9 De Luca V....Kennedy J.L. (2006)
- NMR structure of the transmembrane domain of the n-ac etylcholine receptor beta2 subunit. (PubMed id 20441771)1, 2 Bondarenko V....Tang P. (2010)
- Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. (PubMed id 17226798)1, 7 Ehringer M.A....Zeiger J.S. (2007)
- Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. (PubMed id 16314871)1, 4 Greenbaum L....Lerer B. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for CHRNB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHRNB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHRNB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHRNB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHRNB2 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CHRNB2 |
|
| | |
About This Section
| Patent Information for CHRNB2 gene:
Search GeneIP for patents involving CHRNB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CHRNB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for CHRNB2 | | OriGene shRNA RFP for CHRNB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHRNB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRNB2 | | | OriGene Protein Over-expression Lysate for CHRNB2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHRNB2 | | OriGene 3'-UTR Clone for CHRNB2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHRNB2 | | OriGene Custom Protein Services for CHRNB2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHRNB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHRNB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRNB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRNB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRNB2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNB2 |
|  |  |  | | | | ThermoFisher Antibodies for CHRNB2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNB2 |
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