Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHRNB2 Gene

protein-coding   GIFtS: 65
GCID: GC01P154540

Cholinergic Receptor, Nicotinic, Beta 2 (Neuronal)

(Previous names: cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cholinergic Receptor, Nicotinic, Beta 2 (Neuronal)1 2     nicotinic1
Cholinergic Receptor, Nicotinic, Beta Polypeptide 2 (Neuronal)1 2     Acetylcholine Receptor, Nicotinic, Beta 2 (Neuronal)2
EFNL32 5     nAChRB22
Acetylcholine Receptor1     Neuronal Acetylcholine Receptor Subunit Beta-22
Beta 2 (Neuronal)1     Neuronal Nicotinic Acetylcholine Receptor Beta 22

External Ids:    HGNC: 19621   Entrez Gene: 11412   Ensembl: ENSG000001607167   OMIM: 1185075   UniProtKB: P177873   

Export aliases for CHRNB2 gene to outside databases

Previous GC identifers: GC01P152356 GC01P150271 GC01P151315 GC01P151758 GC01P151759 GC01P151353 GC01P152806 GC01P125903


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHRNB2 Gene:
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta
subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium
across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of
several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe
epilepsy. (provided by RefSeq, Jul 2008)

GeneCards Summary for CHRNB2 Gene: 
CHRNB2 (cholinergic receptor, nicotinic, beta 2 (neuronal)) is a protein-coding gene. Diseases associated with CHRNB2 include autosomal dominant nocturnal frontal lobe epilepsy, and chrnb2-related nocturnal frontal lobe epilepsy, autosomal dominant, and among its related super-pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Presynaptic nicotinic acetylcholine receptors. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and ligand-gated ion channel activity. An important paralog of this gene is CHRNA5.

UniProtKB/Swiss-Prot: ACHB2_HUMAN, P17787
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all
subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions

summary for CHRNB2 Gene:
Nicotinic alpha4beta2 receptors have high affinity for nicotine and account for >90% of [3H]-nicotine
binding to brain tissues. A stoichiometry of (alpha4)2(beta2)3 has been proposed, generating two agonist
binding sites consistent with the model of the muscle nAChR. Manipulation of the stoichiometry of
alpha4beta2 nAChRs expressed in Xenopus oocytes indicates that (alpha4)3(beta2)2 nAChRs are also viable,
displaying lower affinity for ACh and higher Ca2+ permeability; whether native nAChRs with this subunit
stoichiometry exist is not known. Transgenic knockout of either of these subunits eliminates nicotine self
administration, whereas virally targeted re-expression of the beta2 subunit in mesolimbic areas of beta2
knockout mice recovers this behavior, implicating a role for alpha4beta2 nAChRs in nicotine addiction.
alpha4beta2 nAChRs are highly expressed in the thalamus and have been suggested to have a putative role in
the thalamo-cortical circuitry . As a consequence of their putative role in thalamo-cortical circuitry, gain
of function mutations in the M2 domain of either the alpha4 or beta2 subunit give rise to some forms of
autosomal dominant nocturnal frontal lobe epilepsy. The human genes encoding the nicotinic alpha4 and beta2
receptor subunits have been localized to chromosomes 13 (q13.2-q13.3) and 1 (1q21.3) respectively.

Gene Wiki entry for CHRNB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHRNB2 gene promoter:
         AhR   Egr-3   HOXA3   NRSF form 1   CUTL1   NRSF form 2   Evi-1   GATA-2   Arnt   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRNB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHRNB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRNB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

CHRNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRNB2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154540:  view genomic region     (about GC identifiers)

Start:
154,540,257 bp from pter      End:
154,552,502 bp from pter
Size:
12,246 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACHB2_HUMAN, P17787 (See protein sequence)
Recommended Name: Neuronal acetylcholine receptor subunit beta-2 precursor  
Size: 502 amino acids; 57019 Da
Subunit: Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be
combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be
heteropentamers. Interacts with RIC3; which is required for proper folding and assembly
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
membrane; Multi-pass membrane protein
5 PDB 3D structures from and Proteopedia for CHRNB2:
2GVT (3D)        2K58 (3D)        2K59 (3D)        2KSR (3D)        2LM2 (3D)    
Secondary accessions: Q9UEH9

Explore the universe of human proteins at neXtProt for CHRNB2: NX_P17787

Explore proteomics data for CHRNB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17787

  • CHRNB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHRNB2 Protein Expression
    REFSEQ proteins: NP_000739.1  
    ENSEMBL proteins: 
     ENSP00000357461  
    Reactome Protein details: P17787
    Human Recombinant Protein Products for CHRNB2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CHRNB2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CHRNB2
    GenScript Custom Purified and Recombinant Proteins Services for CHRNB2
    Novus Biologicals CHRNB2 Protein
    Novus Biologicals CHRNB2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005892acetylcholine-gated channel complex IDA8906617
    GO:0009897external side of plasma membrane ISS--
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS8906617

    CHRNB2 for ontologies           About GeneDecksing



    CHRNB2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CHRNB2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CHRNB2
    OriGene Custom Antibody Services for CHRNB2
    GenScript Custom Superior Antibodies Services for CHRNB2
    Novus Biologicals CHRNB2 Antibodies
    Abcam antibodies for CHRNB2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CHRNB2
    LSBio Antibodies in human, mouse, rat for CHRNB2 

    Assay Products for CHRNB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHRNB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHRNB2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CHRN: Ligand-gated ion channels / Acetylcholine receptors, nicotinic
    CHR: Cholinergic receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: β2 
    Nicotinic acetylcholine receptors

    5/6 InterPro protein domains (see all 6):
     IPR027361 Acetylcholine_rcpt_TM
     IPR002394 Nicotinic_acetylcholine_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry P17787

    ProtoNet protein and cluster: P17787

    2 Blocks protein domains:
    IPB002394 Nicotinic acetylcholine receptor signature
    IPB006201 Neurotransmitter-gated ion-channel


    UniProtKB/Swiss-Prot: ACHB2_HUMAN, P17787
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1)
    subfamily. Beta-2/CHRNB2 sub-subfamily


    CHRNB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACHB2_HUMAN, P17787
    Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all
    subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions

         Genatlas biochemistry entry for CHRNB2:
    cholinergic receptor,nicotinic,beta 2 polypeptide,neuronal

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004889acetylcholine-activated cation-selective channel activity TAS--
    GO:0005230extracellular ligand-gated ion channel activity ----
    GO:0005515protein binding ----
    GO:0015276ligand-gated ion channel activity TAS--
    GO:0015464acetylcholine receptor activity IDA8906617
         
    CHRNB2 for ontologies           About GeneDecksing


    Phenotypes:
         15/17 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chrnb2) (see all 17):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  growth/size 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  normal  renal/urinary system 

    CHRNB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Chrnb2tm1Mdb for CHRNB2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHRNB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHRNB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHRNB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHRNB2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHRNB2
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate CHRNB2 (see all 24):
    hsa-miR-676 hsa-miR-148b hsa-miR-301a hsa-miR-486-3p hsa-miR-3684 hsa-miR-650 hsa-miR-130b hsa-miR-3612
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHRNB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRNB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHRNB2
    Sirion Biotech Customized adenovirus for overexpression of CHRNB2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CHRNB2 (see all 7)
    OriGene ORF clones in mouse, rat for CHRNB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHRNB2 (NM_000748)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRNB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNB2
    Sirion Biotech Customized lentivirus for stable overexpression of CHRNB2 
                         Customized lentivirus expression plasmids for stable overexpression of CHRNB2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHRNB2
    Search LifeMap BioReagents cell lines for CHRNB2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHRNB2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    2Presynaptic nicotinic acetylcholine receptors
    Presynaptic nicotinic acetylcholine receptors0.86
    Highly calcium permeable postsynaptic nicotinic acetylcholine receptors0.82
    Acetylcholine Binding And Downstream Events0.86
    Highly calcium permeable nicotinic acetylcholine receptors0.82
    Activation of Nicotinic Acetylcholine Receptors0.86
    Highly sodium permeable acetylcholine nicotinic receptors0.58
    Postsynaptic nicotinic acetylcholine receptors0.86
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    5Circadian entrainment
    Cholinergic synapse0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CHRNB2
        Calcium channels

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CHRNB2
        eNOS Signaling

    2 BioSystems Pathways for CHRNB2
        Nicotine Activity on Dopaminergic Neurons
    SIDS Susceptibility Pathways

    5/10        Reactome Pathways for CHRNB2 (see all 10)
        Activation of Nicotinic Acetylcholine Receptors
    Transmission across Chemical Synapses
    Acetylcholine Binding And Downstream Events
    Highly calcium permeable nicotinic acetylcholine receptors
    Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

    1 PharmGKB Pathway for CHRNB2
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    3         Kegg Pathways  (Kegg details for CHRNB2):
        Neuroactive ligand-receptor interaction
    Cholinergic synapse
    Nicotine addiction


    CHRNB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHRNB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/18 Interacting proteins for CHRNB2 (P177873 ENSP000003574614) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRNA2Q158223, ENSP000002401324I2D: score=2 STRING: ENSP00000240132
    CHRNA4P436813, ENSP000003592854I2D: score=2 STRING: ENSP00000359285
    CRELD2Q6UXH13, ENSP000003839384I2D: score=1 STRING: ENSP00000383938
    PRKAA1Q131313I2D: score=1 
    CHRNA3ENSP000003156024STRING: ENSP00000315602
    About this table

    Gene Ontology (GO): 5/45 biological process terms (GO ID links to tree view) (see all 45):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001508regulation of action potential ----
    GO:0001661conditioned taste aversion IEA--
    GO:0001666response to hypoxia IDA12189247
    GO:0006810transport ----
    GO:0006811ion transport NAS8906617

    CHRNB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHRNB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CHRNB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RJR 2403 oxalatealpha4beta2 selective nicotinic agonist[220662-95-3]
    Desformylflustrabromine hydrochloridePositive allosteric modulator of alpha4beta2[474657-72-2]
    (-)-Nicotine ditartratePrototypical nAChR agonist[65-31-6]
    Varenicline tartrate Orally active, subtype-selective alpha4beta2 partial agonist [375815-87-5]
    Sazetidine A dihydrochloridealpha4beta2 receptor ligand; may act as an agonist or a desensitizer[1197329-42-2]

    2 DrugBank Compounds for CHRNB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Galantamine(-)-Galanthamine (see all 3)357-70-0targetallosteric modulator12137632 11129124 12481195 20480924 12177686 10971048
    NicotineL-Nicotine (see all 2)54-11-5targetagonist19560048 20081230 17226798 16636791 20400469 11006350

    4 Novoseek inferred chemical compound relationships for CHRNB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nicotine 65.1 9 11054772 (3), 19755656 (2), 15154117 (1), 11906688 (1) (see all 5)
    acetylcholine 26.9 2 15964197 (1), 17008177 (1)
    sodium 0 2 16038283 (1), 11579435 (1)
    potassium 0 3 16038283 (1), 11579435 (1)

    Search CenterWatch for drugs/clinical trials and news about CHRNB2 / ACHB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHRNB2 gene: 
    NM_000748.2  

    Unigene Cluster for CHRNB2:

    Cholinergic receptor, nicotinic, beta 2 (neuronal)
    Hs.2306  [show with all ESTs]
    Unigene Representative Sequence: NM_000748
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368476(uc001ffg.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHRNB2
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate CHRNB2 (see all 24):
    hsa-miR-676 hsa-miR-148b hsa-miR-301a hsa-miR-486-3p hsa-miR-3684 hsa-miR-650 hsa-miR-130b hsa-miR-3612
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHRNB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRNB2
    Clone
    Products:
         
    OriGene clones in human, mouse for CHRNB2 (see all 7)
    OriGene ORF clones in mouse, rat for CHRNB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHRNB2 (NM_000748)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRNB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNB2
    Sirion Biotech Customized lentivirus for stable overexpression of CHRNB2 
                         Customized lentivirus expression plasmids for stable overexpression of CHRNB2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHRNB2
    OriGene qSTAR qPCR primer pairs in human, mouse for CHRNB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHRNB2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRNB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNB2

    Additional mRNA sequence: 

    AK313470.1 BC075040.2 BC075041.2 U62437.1 X53179.1 Y08415.1 

    1 DOTS entry:

    DT.100752185 

    24/42 AceView cDNA sequences (see all 42):

    BQ071347 NM_000748 BE796758 BX951882 BC075041 U62437 BE796482 F12988 
    BC075040 X53179 Y08415 BQ719128 C05589 AI263160 BF528224 BG472114 
    AL712090 BX493862 BX505019 BX283415 AI808724 BE261002 BG820708 R40506 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHRNB2 expression in normal human tissues (normalized intensities)      CHRNB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTTGTCTTT
    CHRNB2 Expression
    About this image


    CHRNB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Olfactory Bulb   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             retinal amacrine cell p0   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/ventricle   

    See CHRNB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHRNB2

    SOURCE GeneReport for Unigene cluster: Hs.2306
        SABiosciences Expression via Pathway-Focused PCR Array including CHRNB2: 
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHRNB2
    OriGene qSTAR qPCR primer pairs in human, mouse for CHRNB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHRNB2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRNB2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CHRNB2 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrnb21 , 5 cholinergic receptor, nicotinic, beta polypeptide 2 more1, 5 87.62(n)1
    94.21(a)1
      3 (39.19 cM)5
    114441  NM_009602.41  NP_033732.21 
     897534485 
    chicken
    (Gallus gallus)
    Aves CHRNB21 cholinergic receptor, nicotinic, beta 2 (neuronal) 82.76(n)
    88.25(a)
      395605  NM_204813.1  NP_990144.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHRNB26
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL344076.1(74115-84434)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005377131 neuronal acetylcholine receptor subunit beta-2-like 75.29(n)
    83.64(a)
      100537713  XM_003200183.1  XP_003200231.1 


    ENSEMBL Gene Tree for CHRNB2 (if available)
    TreeFam Gene Tree for CHRNB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHRNB2 gene
    CHRNA52  CHRNA22  CHRNA12  CHRNA62  CHRNA72  CHRNE2  CHRNB42  CHRNA42  
    CHRNA102  CHRNA92  CHRNG2  CHRNA32  CHRFAM7A2  CHRNB32  CHRNB12  CHRND2  
    17 SIMAP similar genes for CHRNB2 using alignment to 2 protein entries:     ACHB2_HUMAN (see all proteins):
    CHRNB4    CHRNA6    CHRNA7-2    CHRNA3    CHRNA2    CHRNB3
    CHRNA1    CHRNA5    CHRNA7    CHRNA9    CHRND    CHRFAM7A
    CHRNE    CHRNA10    CHRNB1    CHRNG    HTR3A

    CHRNB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/674 SNPs in CHRNB2 are shown (see all 674)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0127144
    Epilepsy, nocturnal frontal lobe, 3 (ENFL3)4--see VAR_0127142 V L mis40--------
    VAR_0127154
    Epilepsy, nocturnal frontal lobe, 3 (ENFL3)4--see VAR_0127152 V M mis40--------
    rs743152911,2
    Cpathogenic1161046215(+) AGATCA/C/G/
            
    TGCCT
    4 M L V mis10--------
    rs38410621,2
    C--154550944(+) ATGAC-/AGAGCTA 1 -- ut312Minor allele frequency- AG:0.25NA 4
    rs38410631,2
    C--154552517(+) ATCAC-/TGTGATT 1 -- ds50010--------
    rs1920153031,2
    --154552605(+) GGCCCA/CCGGGA 1 -- ds50010--------
    rs1841670311,2
    --154552606(+) GCCCCA/CGGGAG 1 -- ds50010--------
    rs1432877991,2
    --154552632(+) TGGGCA/GGAGGT 1 -- ds50010--------
    rs751950331,2
    C,F--154552837(+) TCTTGC/TGCTCC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1821891771,2
    --161040520(+) TTAAGG/TCTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHRNB2 (154540257 - 154552502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CHRNB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv521887CNV Gain19592680


    Human Gene Mutation Database (HGMD): CHRNB2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CHRNB2
    DNA2.0 Custom Variant and Variant Library Synthesis for CHRNB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 118507   
    OMIM disorders: 605375  
    UniProtKB/Swiss-Prot: ACHB2_HUMAN, P17787
  • Epilepsy, nocturnal frontal lobe, 3 (ENFL3) [MIM:605375]: An autosomal dominant focal epilepsy
    characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/23 diseases for CHRNB2 (see all 23):    About MalaCards
    autosomal dominant nocturnal frontal lobe epilepsy    chrnb2-related nocturnal frontal lobe epilepsy, autosomal dominant    epilepsy, nocturnal frontal lobe, 3    frontal lobe epilepsy
    nicotine addiction    early onset absence epilepsy    nicotine dependence    focal epilepsy
    pandas    idiopathic generalized epilepsy    febrile seizures    neuronitis
    narcolepsy    schizophrenia    alzheimer's disease    down syndrome
    dementia    bipolar disorder    alcoholism    hypoxia

    3 diseases from the University of Copenhagen DISEASES database for CHRNB2:
    Nicotine dependence     Focal epilepsy     Early onset absence epilepsy

    CHRNB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for CHRNB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epilepsy frontal lobe 94.2 14 11952766 (2), 17900292 (2), 17602836 (1), 18534914 (1) (see all 11)
    seizures febrile 55.9 2 19853223 (1), 11579435 (1)
    epilepsy 53.9 4 15964197 (1), 17385675 (1), 19853223 (1), 11579435 (1)
    epilepsy generalized 53.7 1 11579435 (1)
    smoking habit 53.7 5 11054772 (2), 15154117 (1), 11906688 (1), 15790597 (1)
    alzheimers disease 29.9 1 17192785 (1)
    schizophrenia 27.5 3 18762859 (3)

    GeneTests: CHRNB2
    GeneReviews: CHRNB2
    Genetic Association Database (GAD): CHRNB2
    Human Genome Epidemiology (HuGE) Navigator: CHRNB2 (42 documents)

    Export disorders for CHRNB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHRNB2 gene, integrated from 9 sources (see all 124):
    (articles sorted by number of sources associating them with CHRNB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2). (PubMed id 11906688)1, 2, 4, 9 Lueders K.K....Hamer D.H. (2002)
    2. Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. (PubMed id 16636791)1, 4, 7, 9 De Luca V....Kennedy J.L. (2006)
    3. Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. (PubMed id 17226798)1, 4, 7 Ehringer M.A....Zeiger J.S. (2007)
    4. Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population. (PubMed id 18762859)1, 4, 9 Kishi T....Iwata N. (2008)
    5. The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3). (PubMed id 9921897)1, 2, 9 Rempel N.... Steinlein O.K. (1998)
    6. Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence. (PubMed id 11054772)1, 4, 9 Silverman M.A....Straub R.E. (2000)
    7. A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy. (PubMed id 19058950)1, 4, 9 Chen Y....Xu Q. (2009)
    8. Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population. (PubMed id 18991851)1, 4, 9 Kishi T....Iwata N. (2008)
    9. Association of idiopathic generalized epilepsy with polymorphisms in the neuronal nicotinic acetylcholine receptor subunits. (PubMed id 17385675)1, 4, 9 Lee C.C....Tsai F.J. (2007)
    10. Assessment of Alzheimer's disease case-control associations using family-based methods. (PubMed id 18830724)1, 4, 9 Schjeide B.M....Bertram L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1141 HGNC: 1962 AceView: CHRNB2 Ensembl:ENSG00000160716 euGenes: HUgn1141
    ECgene: CHRNB2 Kegg: 1141 H-InvDB: CHRNB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHRNB2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CHRNB2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHRNB2 gene:
    Search GeneIP for patents involving CHRNB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CHRNB2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CHRNB2   OriGene RNAi products in human, mouse, rat for CHRNB2  
     OriGene qPCR primer pairs and template standards for CHRNB2   OriGene Protein Over-expression Lysate for CHRNB2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CHRNB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHRNB2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CHRNB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHRNB2   OriGene Custom Protein Services for CHRNB2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHRNB2
     QIAGEN SeqTarget long-range PCR primers for resequencing CHRNB2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRNB2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRNB2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNB2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRNB2
     GenScript Custom Purified and Recombinant Proteins Services for CHRNB2 GenScript cDNA clones with any tag delivered in your preferred vector for CHRNB2
     GenScript Custom Assay Services for CHRNB2 GenScript Custom Superior Antibodies Services for CHRNB2
     GenScript Custom overexpressing Cell Line Services for CHRNB2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CHRNB2 promoter
     Search Chromatin IP Primers for CHRNB2
     RT2 qPCR Primer Assay in human, mouse, rat CHRNB2
     GNC Network for CHRNB2
     SABiosciences PCR Arrays including human, mouse, rat CHRNB2
     Tocris compounds for CHRNB2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CHRNB2 antibodies
     CHRNB2 proteins
     CHRNB2 lysates
     Antibodies for CHRNB2
     See all of Abcam's Antibodies, Kits and Proteins for CHRNB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CHRNB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNB2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CHRNB2
     SwitchGear Promoter luciferase reporter plasmids for CHRNB2
     ThermoFisher Antibodies for CHRNB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNB2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CHRNB2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHRNB2
    Customized:
     lentivirus for stable overexpression of CHRNB2
     lentivirus expression plasmids for stable overexpression of CHRNB2
     adenovirus for overexpression of CHRNB2
     LSBio Antibodies in human, mouse, rat for CHRNB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHRNB2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4