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Aliases for CHRNB2 Gene

Aliases for CHRNB2 Gene

  • Cholinergic Receptor, Nicotinic, Beta 2 (Neuronal) 2 3
  • Cholinergic Receptor, Nicotinic, Beta Polypeptide 2 (Neuronal) 2 3
  • EFNL3 3 6
  • Beta2 Human Neuronal Nicotinic Acetylcholine Receptor 3
  • Acetylcholine Receptor, Nicotinic, Beta 2 (Neuronal) 3
  • Neuronal Nicotinic Acetylcholine Receptor Beta 2 3
  • Neuronal Acetylcholine Receptor Subunit Beta-2 3
  • Acetylcholine Receptor 2
  • Beta 2 (Neuronal) 2
  • Nicotinic 2
  • NAChRB2 3

External Ids for CHRNB2 Gene

Previous GeneCards Identifiers for CHRNB2 Gene

  • GC01P152356
  • GC01P150271
  • GC01P151315
  • GC01P151758
  • GC01P151759
  • GC01P151353
  • GC01P152806
  • GC01P125903

Summaries for CHRNB2 Gene

Entrez Gene Summary for CHRNB2 Gene

  • Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHRNB2 Gene

CHRNB2 (Cholinergic Receptor, Nicotinic, Beta 2 (Neuronal)) is a Protein Coding gene. Diseases associated with CHRNB2 include epilepsy, nocturnal frontal lobe, 3 and chrnb2-related nocturnal frontal lobe epilepsy, autosomal dominant. Among its related pathways are Nanog in Mammalian ESC Pluripotency and SIDS Susceptibility Pathways. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and ligand-gated ion channel activity. An important paralog of this gene is CHRNA3.

UniProtKB/Swiss-Prot for CHRNB2 Gene

  • After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.

Tocris Summary for CHRNB2 Gene

  • Nicotinic alpha4beta2 receptors have high affinity for nicotine and account for >90% of [3H]-nicotine binding to brain tissues. A stoichiometry of (alpha4)2(beta2)3 has been proposed, generating two agonist binding sites consistent with the model of the muscle nAChR. Manipulation of the stoichiometry of alpha4beta2 nAChRs expressed in Xenopus oocytes indicates that (alpha4)3(beta2)2 nAChRs are also viable, displaying lower affinity for ACh and higher Ca2+ permeability; whether native nAChRs with this subunit stoichiometry exist is not known. Transgenic knockout of either of these subunits eliminates nicotine self administration, whereas virally targeted re-expression of the beta2 subunit in mesolimbic areas of beta2 knockout mice recovers this behavior, implicating a role for alpha4beta2 nAChRs in nicotine addiction. alpha4beta2 nAChRs are highly expressed in the thalamus and have been suggested to have a putative role in the thalamo-cortical circuitry . As a consequence of their putative role in thalamo-cortical circuitry, gain of function mutations in the M2 domain of either the alpha4 or beta2 subunit give rise to some forms of autosomal dominant nocturnal frontal lobe epilepsy. The human genes encoding the nicotinic alpha4 and beta2 receptor subunits have been localized to chromosomes 13 (q13.2-q13.3) and 1 (1q21.3) respectively.

Gene Wiki entry for CHRNB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNB2 Gene

Genomics for CHRNB2 Gene

Regulatory Elements for CHRNB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHRNB2 Gene

154,567,781 bp from pter
154,580,026 bp from pter
12,246 bases
Plus strand

Genomic View for CHRNB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNB2 Gene

Proteins for CHRNB2 Gene

  • Protein details for CHRNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal acetylcholine receptor subunit beta-2
    Protein Accession:
    Secondary Accessions:
    • Q9UEH9

    Protein attributes for CHRNB2 Gene

    502 amino acids
    Molecular mass:
    57019 Da
    Quaternary structure:
    • Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Interacts with RIC3; which is required for proper folding and assembly.

    Three dimensional structures from OCA and Proteopedia for CHRNB2 Gene

neXtProt entry for CHRNB2 Gene

Proteomics data for CHRNB2 Gene at MOPED

Post-translational modifications for CHRNB2 Gene

  • Glycosylation at Asn51, Asn168, and Asn485
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHRNB2 Gene

Domains for CHRNB2 Gene

Gene Families for CHRNB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.
genes like me logo Genes that share domains with CHRNB2: view

Function for CHRNB2 Gene

Molecular function for CHRNB2 Gene

GENATLAS Biochemistry:
cholinergic receptor,nicotinic,beta 2 polypeptide,neuronal
UniProtKB/Swiss-Prot Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.

Gene Ontology (GO) - Molecular Function for CHRNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004889 acetylcholine-activated cation-selective channel activity TAS 20438829
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0005515 protein binding --
GO:0008144 drug binding IEA --
GO:0015276 ligand-gated ion channel activity TAS 20438829
genes like me logo Genes that share ontologies with CHRNB2: view
genes like me logo Genes that share phenotypes with CHRNB2: view

Animal Models for CHRNB2 Gene

MGI Knock Outs for CHRNB2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CHRNB2 Gene

Localization for CHRNB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNB2 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CHRNB2 Gene COMPARTMENTS Subcellular localization image for CHRNB2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CHRNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005892 acetylcholine-gated channel complex IDA 8906617
GO:0009897 external side of plasma membrane ISS --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 8906617
genes like me logo Genes that share ontologies with CHRNB2: view

Pathways for CHRNB2 Gene

genes like me logo Genes that share pathways with CHRNB2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHRNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential IEA --
GO:0001661 conditioned taste aversion IEA --
GO:0001666 response to hypoxia IDA 12189247
GO:0006810 transport --
GO:0006811 ion transport NAS 8906617
genes like me logo Genes that share ontologies with CHRNB2: view

Compounds for CHRNB2 Gene

(7) Drugbank Compounds for CHRNB2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • d-Methorphan
125-71-3 Target antagonist approved
  • [CH2Me(OH)]
64-17-5 702 Target approved
  • (-)-Galanthamine
357-70-0 908828 Target allosteric modulator approved
  • (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine
54-11-5 942 Target agonist approved
178052 Target investigational

(5) Tocris Compounds for CHRNB2 Gene

Compound Action Cas Number
(-)-Nicotine ditartrate Prototypical nAChR agonist [65-31-6]
Desformylflustrabromine hydrochloride Positive allosteric modulator of alpha4beta2 [951322-11-5]
RJR 2403 oxalate alpha4beta2 selective nicotinic agonist [220662-95-3]
Sazetidine A dihydrochloride alpha4beta2 receptor ligand; may act as an agonist or a desensitizer [1197329-42-2]
Varenicline tartrate Orally active, subtype-selective alpha4beta2 partial agonist [375815-87-5]

(36) ApexBio Compounds for CHRNB2 Gene

Compound Action Cas Number
Acetylcholine Chloride Major transmitter at many nervous sites [60-31-1]
Acetylcysteine Antioxidant;mucolytic agent [616-91-1]
Adiphenine HCl [50-42-0]
Atropine MAChRs antagonist [5908-99-6]
Bethanechol chloride Muscarinic receptor agonist [590-63-6]
Catharanthine [2468-21-5]
Decamethonium Bromide [541-22-0]
Diphemanil Methylsulfate [62-97-5]
Flavoxate hydrochloride [3717-88-2]
Galanthamine HBr Acetylcholinesterase inhibitor [1953-4-4]
Gallamine Triethiodide [65-29-2]
Hexamethonium Bromide [55-97-0]
Homatropine Bromide Muscarinic AChR antagonist [51-56-9]
Homatropine Methylbromide Muscarinic AChR antagonist [80-49-9]
Hyoscyamine [101-31-5]
Ipratropium Bromide [22254-24-6]
LY2119620 [886047-22-9]
Methscopolamine Muscarinic acetylcholine receptor blocker [155-41-9]
Neostigmine Bromide Cholinesterase inhibitor [114-80-7]
Nitenpyram [150824-47-8]
Orphenadrine Citrate Antiparkinsonian and analgesic drug [4682-36-4]
Otilonium Bromide [26095-59-0]
Oxybutynin [5633-20-5]
Oxybutynin chloride [1508-65-2]
Pancuronium dibromide AChR antagonist [15500-66-0]
Paroxetine HCl Antidepressant agents [78246-49-8]
PNU-120596 "α7 nAChR modulator,positive allosteric" [501925-31-1]
Pregnenolone [145-13-1]
Rivastigmine Tartrate [129101-54-8]
Rocuronium Bromide TGF-βR I kinase inhibitor [119302-91-9]
Succinylcholine Chloride Dihydrate [6101-15-1]
Tiotropium Bromide hydrate Muscarinic antagonist [139404-48-1]
Tropicamide Antimuscarinic drug [1508-75-4]
Varenicline Tartrate "Subtype-selective agonist of α4β2 nicotinic receptors,orally active" [375815-87-5]
Vecuronium Bromide Nonpolarizing neuromuscular relaxant [50700-72-6]
vinblastine [865-21-4]

(4) Novoseek inferred chemical compound relationships for CHRNB2 Gene

Compound -log(P) Hits PubMed IDs
nicotine 65.1 8
acetylcholine 26.9 2
sodium 0 2
potassium 0 2
genes like me logo Genes that share compounds with CHRNB2: view

Transcripts for CHRNB2 Gene

mRNA/cDNA for CHRNB2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(42) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHRNB2 Gene

Cholinergic receptor, nicotinic, beta 2 (neuronal):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNB2 Gene

No ASD Table

Relevant External Links for CHRNB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRNB2 Gene

mRNA expression in normal human tissues for CHRNB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHRNB2 Gene

This gene is overexpressed in Brain - Cortex (6.9), Brain - Anterior cingulate cortex (BA24) (5.7), Brain - Frontal Cortex (BA9) (5.7), Brain - Putamen (basal ganglia) (4.2), Brain - Hippocampus (4.1), and Brain - Nucleus accumbens (basal ganglia) (4.1).

SOURCE GeneReport for Unigene cluster for CHRNB2 Gene Hs.2306

genes like me logo Genes that share expressions with CHRNB2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for CHRNB2 Gene

Orthologs for CHRNB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHRNB2 35
  • 91.62 (n)
  • 96.01 (a)
  • 96 (a)
(Canis familiaris)
Mammalia CHRNB2 35
  • 89.87 (n)
  • 94.55 (a)
  • 94 (a)
(Mus musculus)
Mammalia Chrnb2 35
  • 87.62 (n)
  • 94.21 (a)
Chrnb2 16
Chrnb2 36
  • 94 (a)
(Pan troglodytes)
Mammalia CHRNB2 35
  • 99.73 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Chrnb2 35
  • 87.83 (n)
  • 95.64 (a)
(Monodelphis domestica)
Mammalia CHRNB2 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
(Gallus gallus)
Aves CHRNB2 35
  • 82.76 (n)
  • 88.25 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia CHRNB2 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chrnb2 35
  • 78.48 (n)
  • 86.08 (a)
(Danio rerio)
Actinopterygii chrnb2b 35
  • 74.88 (n)
  • 84.29 (a)
chrnb2b 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta nAcRalpha-30D 37
  • 33 (a)
nAcRalpha-7E 37
  • 53 (a)
nAcRalpha-80B 37
  • 42 (a)
nAcRalpha-96Aa 37
  • 51 (a)
nAcRalpha-96Ab 37
  • 50 (a)
nAcRbgr-64B 37
  • 42 (a)
nAcRbgr-96A 37
  • 45 (a)
nAcRalpha-96Aa 35
  • 58.46 (n)
  • 49.67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002974 35
  • 56.22 (n)
  • 50.33 (a)
(Caenorhabditis elegans)
Secernentea acr-12 37
  • 43 (a)
acr-13 37
  • 30 (a)
acr-17 37
  • 33 (a)
acr-18 37
  • 28 (a)
acr-2 37
  • 48 (a)
acr-22 37
  • 29 (a)
acr-3 37
  • 41 (a)
acr-5 37
  • 31 (a)
acr-8 37
  • 35 (a)
deg-3 37
  • 28 (a)
F11C7.1 37
  • 29 (a)
F18G5.4 37
  • 35 (a)
lev-1 37
  • 40 (a)
unc-29 37
  • 41 (a)
unc-38 37
  • 40 (a)
unc-63 37
  • 45 (a)
Y44A6E.1 37
  • 28 (a)
Y57G11C.2 37
  • 25 (a)
Y73F8A.30 37
  • 30 (a)
ZK973.5 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for CHRNB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNB2 Gene

Gene Tree for CHRNB2 (if available)
Gene Tree for CHRNB2 (if available)

Paralogs for CHRNB2 Gene

(17) SIMAP similar genes for CHRNB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHRNB2: view

Variants for CHRNB2 Gene

Sequence variations from dbSNP and Humsavar for CHRNB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1126885 -- 154,575,964(+) CACCC(A/T)GCCAC utr-variant-3-prime
rs1139339 -- 154,579,074(+) GTTAT(G/T)GAAAA utr-variant-3-prime
rs2072658 -- 154,567,749(+) TTCCT(A/G)GGACC upstream-variant-2KB
rs2072659 -- 154,576,045(+) CAGAT(C/G)CATCC utr-variant-3-prime
rs2072660 -- 154,576,245(+) AGTGA(C/T)GGGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CHRNB2 Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV Gain 19592680

Relevant External Links for CHRNB2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNB2 Gene

Disorders for CHRNB2 Gene

(1) OMIM Diseases for CHRNB2 Gene (118507)


  • Epilepsy, nocturnal frontal lobe, 3 (ENFL3) [MIM:605375]: An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. {ECO:0000269 PubMed:11062464, ECO:0000269 PubMed:11104662}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for CHRNB2 Gene

(7) Novoseek inferred disease relationships for CHRNB2 Gene

Disease -log(P) Hits PubMed IDs
epilepsy frontal lobe 94.2 13
seizures febrile 55.9 2
epilepsy 53.9 4
epilepsy generalized 53.7 1
smoking habit 53.7 5

Relevant External Links for CHRNB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CHRNB2: view

No data available for Genatlas for CHRNB2 Gene

Publications for CHRNB2 Gene

  1. Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2). (PMID: 11906688) Lueders K.K. … Hamer D.H. (Nicotine Tob. Res. 2002) 3 4 23 48
  2. Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. (PMID: 16636791) De Luca V. … Kennedy J.L. (Exp Brain Res 2006) 3 23 25 48
  3. Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease. (PMID: 12214130) Kawamata J. … Shimohama S. (J. Alzheimers Dis. 2002) 3 23 48
  4. The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3). (PMID: 9921897) Rempel N. … Steinlein O.K. (Hum. Genet. 1998) 3 4 23
  5. Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes. (PMID: 10441742) Lueders K.K. … Hamer D. (Mamm. Genome 1999) 3 4 23

Products for CHRNB2 Gene

Sources for CHRNB2 Gene

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