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CHRNA9 Gene

protein-coding   GIFtS: 62
GCID: GC04P040337

Cholinergic Receptor, Nicotinic, Alpha 9 (Neuronal)

(Previous names: cholinergic receptor, nicotinic, alpha polypeptide 9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cholinergic Receptor, Nicotinic, Alpha 9 (Neuronal)1 2     Acetylcholine Receptor, Neuronal Nicotinic, Alpha-9 Subunit2
Cholinergic Receptor, Nicotinic, Alpha Polypeptide 91 2     NACHR Alpha 92
NACHRA92 3     Neuronal Acetylcholine Receptor Protein, Alpha-9 Subunit2
Acetylcholine Receptor1     Neuronal Acetylcholine Receptor Subunit Alpha-92
Alpha 9 (Neuronal)1     Nicotinic Acetylcholine Receptor Subunit Alpha 92
nicotinic1     NACHR Alpha-93
HSA2433422     Nicotinic Acetylcholine Receptor Subunit Alpha-93

External Ids:    HGNC: 140791   Entrez Gene: 555842   Ensembl: ENSG000001743437   OMIM: 6051165   UniProtKB: Q9UGM13   

Export aliases for CHRNA9 gene to outside databases

Previous GC identifers: GC04P040401 GC04P040620 GC04P040187 GC04P040253 GC04P040178 GC04P040032 GC04P039659


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHRNA9 Gene:
This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene
superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels.
This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of
the adult cochlea. (provided by RefSeq, Feb 2012)

GeneCards Summary for CHRNA9 Gene:
CHRNA9 (cholinergic receptor, nicotinic, alpha 9 (neuronal)) is a protein-coding gene. Diseases associated with CHRNA9 include pemphigus vulgaris, and nicotine dependence. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and calcium channel activity. An important paralog of this gene is HTR3E.

UniProtKB/Swiss-Prot: ACHA9_HUMAN, Q9UGM1
Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may
induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting
channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium,
the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may
lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the
range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion

Gene Wiki entry for CHRNA9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_006238.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHRNA9 gene promoter:
         Pbx1a   MEF-2   FOXD1   AP-4   RORalpha2   MEF-2A   RORalpha1   IRF-2   HSF2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRNA9 promoter sequence
   Search Chromatin IP Primers for CHRNA9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRNA9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

CHRNA9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRNA9 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P040337:  view genomic region     (about GC identifiers)

Start:
40,337,346 bp from pter      End:
40,357,234 bp from pter
Size:
19,889 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACHA9_HUMAN, Q9UGM1 (See protein sequence)
Recommended Name: Neuronal acetylcholine receptor subunit alpha-9 precursor  
Size: 479 amino acids; 54807 Da
Subunit: Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10. The native outer hair cell
receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers
Miscellaneous: The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological
profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine
(a muscarinic acetylcholine receptor antagonist)
Secondary accessions: Q14CY7 Q4W5A2 Q9NYV2

Explore the universe of human proteins at neXtProt for CHRNA9: NX_Q9UGM1

Explore proteomics data for CHRNA9 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57, Asn170
  • Modification sites at PhosphoSitePlus

  • See CHRNA9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060051.2  
    ENSEMBL proteins: 
     ENSP00000312663  
    Reactome Protein details: Q9UGM1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHRN: Ligand-gated ion channels / Acetylcholine receptors, nicotinic
    CHR: Cholinergic receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha9
    Nicotinic acetylcholine receptors

    Selected InterPro protein domains (see all 6):
     IPR027361 Acetylcholine_rcpt_TM
     IPR002394 Nicotinic_acetylcholine_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry Q9UGM1

    ProtoNet protein and cluster: Q9UGM1

    2 Blocks protein domains:
    IPB002394 Nicotinic acetylcholine receptor signature
    IPB006201 Neurotransmitter-gated ion-channel


    UniProtKB/Swiss-Prot: ACHA9_HUMAN, Q9UGM1
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1)
    subfamily. Alpha-9/CHRNA9 sub-subfamily


    CHRNA9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACHA9_HUMAN, Q9UGM1
    Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may
    induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting
    channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium,
    the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may
    lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the
    range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004889acetylcholine-activated cation-selective channel activity IEA--
    GO:0005230extracellular ligand-gated ion channel activity ----
    GO:0005262calcium channel activity IEA--
    GO:0005515protein binding ----
         
    CHRNA9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHRNA9:
     Decreased viability of wild-ty 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Chrna9):
     adipose tissue  behavior/neurological  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  nervous system  vision/eye 

    CHRNA9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Chrna9tm1Bedv for CHRNA9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHRNA9
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACHA9_HUMAN, Q9UGM1: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable).
    Cell membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005892acetylcholine-gated channel complex IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--

    CHRNA9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHRNA9 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of Nicotinic Acetylcholine Receptors
    Activation of Nicotinic Acetylcholine Receptors
    Highly calcium permeable postsynaptic nicotinic acetylcholine receptors0.00
    Acetylcholine Binding And Downstream Events0.00
    Postsynaptic nicotinic acetylcholine receptors0.00
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    3CREB Pathway
    Intracellular Calcium Signaling0.50
    4Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    5Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CHRNA9
        eNOS Signaling
    Intracellular Calcium Signaling

    1 Reactome Pathway for CHRNA9
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors


    1 Kegg Pathway  (Kegg details for CHRNA9):
        Neuroactive ligand-receptor interaction


    CHRNA9 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHRNA9
    Interactions:

        Search GeneGlobe Interaction Network for CHRNA9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for CHRNA9 (ENSP000003126634) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRNA1ENSP000002610074STRING: ENSP00000261007
    CHRNA2ENSP000002401324STRING: ENSP00000240132
    CHRNA3ENSP000003156024STRING: ENSP00000315602
    CHRNA4ENSP000003592854STRING: ENSP00000359285
    CHRNA5ENSP000002995654STRING: ENSP00000299565
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport ----
    GO:0006812cation transport ----
    GO:0007204positive regulation of cytosolic calcium ion concentration IGI18420419
    GO:0007268synaptic transmission TAS--

    CHRNA9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHRNA9 (ACHA9)

    1 HMDB Compound for CHRNA9    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for CHRNA9    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Galantamine(-)-Galanthamine (see all 3)357-70-0targetallosteric modulator12137632 11129124 12481195 20480924 12177686 10971048
    NicotineL-Nicotine (see all 2)54-11-5targetagonist19560048 20081230 20400469 11006350
    Tetraethylammonium-- 66-40-0targetagonist inhibitor12824448

    8 IUPHAR Ligands for CHRNA9 (alpha9)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]methyllycaconitine
    NoneNone8.12--
    alpha-conotoxin RgIA
    AntagonistAntagonist8.12--
    alpha-bungarotoxin
    AntagonistAntagonist8.12--
    strychnine
    AntagonistAntagonist8.12--
    [125I]alpha-bungarotoxin
    NoneNone8.12--
    muscarine
    AntagonistAntagonist8.12--
    [3H]alpha-bungarotoxin
    NoneNone8.12--
    nicotine
    AntagonistAntagonist8.12--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHRNA9 gene: 
    NM_017581.3  

    Unigene Cluster for CHRNA9:

    Cholinergic receptor, nicotinic, alpha 9 (neuronal)
    Hs.272278  [show with all ESTs]
    Unigene Representative Sequence: NM_017581
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310169(uc003gva.1) ENST00000502377 ENST00000509518
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    Additional mRNA sequence: 

    AF227732.1 AJ243342.1 BC113549.1 BC113575.1 

    1 DOTS entry:

    DT.91654408 

    6 AceView cDNA sequences:

    AF227732 AJ243342 NM_017581 BP870578 BG190899 BF695750 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA9    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -     -           -               
    SP2:                                                            
    SP3:                                                            


    ECgene alternative splicing isoforms for CHRNA9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHRNA9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGATTTTTT
    CHRNA9 Expression
    About this image

    CHRNA9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHRNA9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272278

    UniProtKB/Swiss-Prot: ACHA9_HUMAN, Q9UGM1
    Tissue specificity: Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHRNA9 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrna91 , 5 cholinergic receptor, nicotinic, alpha polypeptide more1, 5 85.46(n)1
    91.02(a)1
      5 (33.84 cM)5
    2312521  NM_001081104.11  NP_001074573.11 
     659349215 
    chicken
    (Gallus gallus)
    Aves CHRNA91 cholinergic receptor, nicotinic, alpha 9 71.09(n)
    75.59(a)
      395522  NM_204760.1  NP_990091.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHRNA96
    cholinergic receptor, nicotinic, alpha 9 (neuronal...
    70(a)
    1 ↔ 1
    5(99983521-99995460)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia chrna91 cholinergic receptor, nicotinic, alpha 9 (neuronal) 70.11(n)
    73.28(a)
      100493319  XM_002933468.2  XP_002933514.2 
    zebrafish
    (Danio rerio)
    Actinopterygii chrna91 cholinergic receptor, nicotinic, alpha 9 71.58(n)
    75.18(a)
      568807  XM_001920859.2  XP_001920894.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta nAcR&bgr;-21C3 nicotinic acetylcholine-activated
    cation-selective more
    31(a)   21D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea acr-223 Acetycholine receptor 34(a)
    (best of 9)
      X(7539074-7541754)   --


    ENSEMBL Gene Tree for CHRNA9 (if available)
    TreeFam Gene Tree for CHRNA9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHRNA9 gene
    HTR3E2  HTR3A2  CHRNA102  HTR3B2  ZACN2  CHRNA72  CHRFAM7A2  HTR3C2  
    HTR3D2  
    18 SIMAP similar genes for CHRNA9 using alignment to 1 protein entry:     ACHA9_HUMAN:
    CHRNA10    CHRNA7-2    CHRNA4    CHRNA6    CHRNA1    CHRNA7
    CHRNA3    CHRFAM7A    CHRNB3    CHRNB2    CHRNA2    CHRNA5
    CHRNB4    CHRND    CHRNB1    CHRNE    CHRNG    HTR3A

    CHRNA9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHRNA9 (see all 668)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339476861,2
    C--40230196(+) TCTCT-/CACACAC 1 -- int10--------
    rs1406596181,2
    C--40335624(+) AGAGG-/CCCCTG 1 -- us2k10--------
    rs68169021,2
    C,F,A,H--40335663(+) AGTGGG/TATAGG 1 -- us2k125Minor allele frequency- T:0.43NS EA NA WA CSA 2344
    rs1924346091,2
    --40335681(+) GGGACA/GCCATT 1 -- us2k10--------
    rs1839369671,2
    --40335890(+) GGATCC/TTGTCT 1 -- us2k10--------
    rs781219341,2
    C,F--40335902(+) TGGCCG/CATCAC 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1154759731,2
    C,F--40335952(+) TCCTCA/GTATAG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1438245831,2
    --40335976(+) AACTCA/TATTTC 1 -- us2k10--------
    rs1511286831,2
    --40336044(+) GCGTGA/GGCACC 1 -- us2k10--------
    rs1406821291,2
    --40336089(+) GGGGCA/GTCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHRNA9 (40337346 - 40357234 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CHRNA9: --
    Human Gene Mutation Database (HGMD): CHRNA9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHRNA9
    DNA2.0 Custom Variant and Variant Library Synthesis for CHRNA9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605116    OMIM disorders: --

    10 diseases for CHRNA9:    
    About MalaCards
    pemphigus vulgaris    nicotine dependence    nicotine addiction    pemphigus
    neuronitis    conjunctivitis    graves' disease    bipolar disorder
    lung cancer    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CHRNA9:
    Nicotine dependence

    CHRNA9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHRNA9
    Human Genome Epidemiology (HuGE) Navigator: CHRNA9 (8 documents)

    Export disorders for CHRNA9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHRNA9 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with CHRNA9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene. (PubMed id 12697997)1, 2, 9 Lustig L.R. and Peng H. (Cytogenet. Genome Res. 2002)
    2. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PubMed id 17559419)1, 4, 9 Rigbi A....Lerer B. (Genes Brain Behav. 2008)
    3. A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. (PubMed id 11752216)1, 2, 9 Sgard F.... Besnard F. (Mol. Pharmacol. 2002)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    5. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. (PubMed id 19259974)1, 4 Saccone N.L....Bierut L.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    7. No evidence for association between 19 cholinergic genes and bipolar disorder. (PubMed id 17373692)1, 4 Shi J....Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    8. Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. (PubMed id 16314871)1, 4 Greenbaum L....Lerer B. (Mol. Psychiatry 2006)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    10. Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. (PubMed id 15531379)1, 2 Peng H....Lustig L.R. (Life Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55584 HGNC: 14079 AceView: CHRNA9 Ensembl:ENSG00000174343 euGenes: HUgn55584
    ECgene: CHRNA9 Kegg: 55584 H-InvDB: CHRNA9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHRNA9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHRNA9 gene:
    Search GeneIP for patents involving CHRNA9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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