Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHRNA9 Gene

Aliases for CHRNA9 Gene

  • Cholinergic Receptor, Nicotinic, Alpha 9 (Neuronal) 2 3
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 9 2 3
  • NACHRA9 3 4
  • Acetylcholine Receptor, Neuronal Nicotinic, Alpha-9 Subunit 3
  • Neuronal Acetylcholine Receptor Protein, Alpha-9 Subunit 3
  • Nicotinic Acetylcholine Receptor Subunit Alpha 9 3
  • Nicotinic Acetylcholine Receptor Subunit Alpha-9 4
  • Neuronal Acetylcholine Receptor Subunit Alpha-9 3
  • Acetylcholine Receptor 2
  • Alpha 9 (Neuronal) 2
  • NACHR Alpha 9 3
  • NACHR Alpha-9 4
  • Nicotinic 2
  • HSA243342 3

External Ids for CHRNA9 Gene

Summaries for CHRNA9 Gene

Entrez Gene Summary for CHRNA9 Gene

  • This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]

GeneCards Summary for CHRNA9 Gene

CHRNA9 (Cholinergic Receptor, Nicotinic, Alpha 9 (Neuronal)) is a Protein Coding gene. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium channel activity and acetylcholine-activated cation-selective channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for CHRNA9 Gene

  • Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).

Gene Wiki entry for CHRNA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA9 Gene

Genomics for CHRNA9 Gene

Genomic Location for CHRNA9 Gene

Start:
40,335,329 bp from pter
End:
40,355,217 bp from pter
Size:
19,889 bases
Orientation:
Plus strand

Genomic View for CHRNA9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRNA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA9 Gene

Regulatory Elements for CHRNA9 Gene

Proteins for CHRNA9 Gene

  • Protein details for CHRNA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGM1-ACHA9_HUMAN
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-9
    Protein Accession:
    Q9UGM1
    Secondary Accessions:
    • Q14CY7
    • Q4W5A2
    • Q9NYV2

    Protein attributes for CHRNA9 Gene

    Size:
    479 amino acids
    Molecular mass:
    54807 Da
    Quaternary structure:
    • Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10 (PubMed:11752216). The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.
    Miscellaneous:
    • The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

    Three dimensional structures from OCA and Proteopedia for CHRNA9 Gene

neXtProt entry for CHRNA9 Gene

Proteomics data for CHRNA9 Gene at MOPED

Post-translational modifications for CHRNA9 Gene

Other Protein References for CHRNA9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHRNA9 Gene

Domains for CHRNA9 Gene

Gene Families for CHRNA9 Gene

HGNC:
  • CHRN :Ligand-gated ion channels / Acetylcholine receptors, nicotinic
  • CHR :Cholinergic receptors
IUPHAR :

Suggested Antigen Peptide Sequences for CHRNA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGM1

UniProtKB/Swiss-Prot:

ACHA9_HUMAN
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.:
    • Q9UGM1
genes like me logo Genes that share domains with CHRNA9: view

Function for CHRNA9 Gene

Molecular function for CHRNA9 Gene

UniProtKB/Swiss-Prot Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).

Gene Ontology (GO) - Molecular Function for CHRNA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004889 acetylcholine-activated cation-selective channel activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0005262 calcium channel activity IEA --
GO:0005515 protein binding --
GO:0022848 acetylcholine-gated cation channel activity IDA 25282151
genes like me logo Genes that share ontologies with CHRNA9: view
genes like me logo Genes that share phenotypes with CHRNA9: view

Animal Models for CHRNA9 Gene

MGI Knock Outs for CHRNA9:

miRNA for CHRNA9 Gene

miRTarBase miRNAs that target CHRNA9

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CHRNA9 Gene

Localization for CHRNA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA9 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRNA9 Gene COMPARTMENTS Subcellular localization image for CHRNA9 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CHRNA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 25282151
GO:0005892 acetylcholine-gated channel complex IDA 25282151
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CHRNA9: view

Pathways for CHRNA9 Gene

genes like me logo Genes that share pathways with CHRNA9: view

Interacting Proteins for CHRNA9 Gene

Gene Ontology (GO) - Biological Process for CHRNA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0006812 cation transport --
GO:0007204 positive regulation of cytosolic calcium ion concentration IGI 18420419
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with CHRNA9: view

Compounds for CHRNA9 Gene

(1) HMDB Compounds for CHRNA9 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Drugbank Compounds for CHRNA9 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Galantamine
  • (-)-Galanthamine
357-70-0 target allosteric modulator
Nicotine
  • L-Nicotine
54-11-5 target agonist
Tetraethylammonium
66-40-0 target agonist inhibitor

(8) IUPHAR Ligand for CHRNA9 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]methyllycaconitine None None 8.12
nicotine Activator Activation 4.7
alpha-conotoxin RgIA Antagonist Antagonist
alpha-bungarotoxin Antagonist Antagonist
strychnine Antagonist Antagonist
[125I]alpha-bungarotoxin None None
muscarine Antagonist Antagonist
[3H]alpha-bungarotoxin None None
genes like me logo Genes that share compounds with CHRNA9: view

Transcripts for CHRNA9 Gene

mRNA/cDNA for CHRNA9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHRNA9 Gene

Cholinergic receptor, nicotinic, alpha 9 (neuronal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA9 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2:
SP3:

Relevant External Links for CHRNA9 Gene

GeneLoc Exon Structure for
CHRNA9
ECgene alternative splicing isoforms for
CHRNA9

Expression for CHRNA9 Gene

mRNA expression in normal human tissues for CHRNA9 Gene

mRNA differential expression in normal tissues according to GTEx for CHRNA9 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (10.3) and Skin - Not Sun Exposed (Suprapubic) (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHRNA9 Gene

SOURCE GeneReport for Unigene cluster for CHRNA9 Gene Hs.272278

mRNA Expression by UniProt/SwissProt for CHRNA9 Gene

Q9UGM1-ACHA9_HUMAN
Tissue specificity: Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells.
genes like me logo Genes that share expressions with CHRNA9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CHRNA9 Gene

Orthologs for CHRNA9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRNA9 35
  • 99.3 (n)
  • 99.16 (a)
CHRNA9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHRNA9 35
  • 89.63 (n)
  • 94.36 (a)
CHRNA9 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRNA9 35
  • 90.26 (n)
  • 95.62 (a)
CHRNA9 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrna9 35
  • 85.46 (n)
  • 91.02 (a)
Chrna9 16
Chrna9 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHRNA9 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHRNA9 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrna9 35
  • 86.57 (n)
  • 91.02 (a)
chicken
(Gallus gallus)
Aves CHRNA9 35
  • 71.09 (n)
  • 75.59 (a)
CHRNA9 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHRNA9 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chrna9 35
  • 70.11 (n)
  • 73.28 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.90 35
zebrafish
(Danio rerio)
Actinopterygii chrna10a 36
  • 53 (a)
OneToMany
chrna9 35
  • 71.58 (n)
  • 75.18 (a)
chrna9 36
  • 55 (a)
OneToMany
CHRNA9 (1 of 3) 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nAcRbeta-21C 36
  • 23 (a)
ManyToMany
nAcRbgr-21C 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea lgc-1 36
  • 19 (a)
ManyToMany
deg-3 37
  • 33 (a)
Y57G11C.2 37
  • 25 (a)
Y44A6E.1 37
  • 28 (a)
C04C3.2 37
  • 28 (a)
Y73F8A.30 37
  • 31 (a)
acr-18 37
  • 30 (a)
F18G5.4 37
  • 33 (a)
acr-22 37
  • 34 (a)
acr-17 37
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
Species with no ortholog for CHRNA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA9 Gene

ENSEMBL:
Gene Tree for CHRNA9 (if available)
TreeFam:
Gene Tree for CHRNA9 (if available)

Paralogs for CHRNA9 Gene

Paralogs for CHRNA9 Gene

Selected SIMAP similar genes for CHRNA9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHRNA9: view

Variants for CHRNA9 Gene

Sequence variations from dbSNP and Humsavar for CHRNA9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4129630 -- 40,341,721(+) GCATT(G/T)ATTGT intron-variant
rs4264869 -- 40,353,109(+) AAGGC(C/T)GAAAG intron-variant
rs4285123 -- 40,353,271(+) agatc(A/T)ctcaa intron-variant
rs4359945 -- 40,335,291(+) AGGGG(A/T)GGGAG upstream-variant-2KB
rs4469115 -- 40,334,910(+) GAGAA(A/C)AAACC upstream-variant-2KB

Relevant External Links for CHRNA9 Gene

HapMap Linkage Disequilibrium report
CHRNA9
Human Gene Mutation Database (HGMD)
CHRNA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CHRNA9 Gene

Disorders for CHRNA9 Gene

(1) University of Copenhagen DISEASES for CHRNA9 Gene

Relevant External Links for CHRNA9

Genetic Association Database (GAD)
CHRNA9
Human Genome Epidemiology (HuGE) Navigator
CHRNA9
genes like me logo Genes that share disorders with CHRNA9: view

No data available for UniProtKB/Swiss-Prot for CHRNA9 Gene

Publications for CHRNA9 Gene

  1. A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. (PMID: 11752216) Sgard F. … Besnard F. (Mol. Pharmacol. 2002) 3 4 23
  2. Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene. (PMID: 12697997) Lustig L.R. … Peng H. (Cytogenet. Genome Res. 2002) 3 4 23
  3. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PMID: 17559419) Rigbi A. … Lerer B. (Genes Brain Behav. 2008) 3 23 48
  4. Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity. (PMID: 11021840) Nguyen V.T. … Grando S.A. (Am. J. Pathol. 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CHRNA9 Gene

Sources for CHRNA9 Gene

Back to Top

Content