Aliases for CHRNA9 Gene
Aliases for CHRNA9 Gene
- Cholinergic Receptor Nicotinic Alpha 9 Subunit 2 3 5
- Cholinergic Receptor, Nicotinic, Alpha Polypeptide 9 2 3
- Cholinergic Receptor, Nicotinic, Alpha 9 (Neuronal) 2 3
- Cholinergic Receptor, Nicotinic Alpha 9 2 3
- NACHRA9 3 4
- Acetylcholine Receptor, Neuronal Nicotinic, Alpha-9 Subunit 3
- Neuronal Acetylcholine Receptor Protein, Alpha-9 Subunit 3
- Acetylcholine Receptor, Nicotinic, Alpha 9 (Neuronal) 2
External Ids for CHRNA9 Gene
- HGNC: 14079
- Entrez Gene: 55584
- Ensembl: ENSG00000174343
- OMIM: 605116
- UniProtKB: Q9UGM1
Previous GeneCards Identifiers for CHRNA9 Gene
- GC04P040401
- GC04P040620
- GC04P040187
- GC04P040253
- GC04P040178
- GC04P040032
- GC04P039659
Summaries for CHRNA9 Gene
-
This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]
GeneCards Summary for CHRNA9 Gene
CHRNA9 (Cholinergic Receptor Nicotinic Alpha 9 Subunit) is a Protein Coding gene. Diseases associated with CHRNA9 include Deafness, Autosomal Recessive 25 and Nicotine Dependence, Protection Against. Among its related pathways are Activation of Nicotinic Acetylcholine Receptors and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium channel activity. An important paralog of this gene is CHRNA10.
UniProtKB/Swiss-Prot for CHRNA9 Gene
-
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA9 Gene
Genomics for CHRNA9 Gene
Regulatory Elements for CHRNA9 Gene
Regulatory Element Products
Genomic Location for CHRNA9 Gene
- Chromosome:
- 4
- Start:
- 40,335,329 bp from pter
- End:
- 40,355,217 bp from pter
- Size:
- 19,889 bases
- Orientation:
- Plus strand
Genomic View for CHRNA9 Gene
- Cytogenetic band:
-
- 4p14 by Ensembl
- 4p14 by Entrez Gene
- 4p14 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHRNA9 Gene
Proteins for CHRNA9 Gene
-
Protein details for CHRNA9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UGM1-ACHA9_HUMAN
- Recommended name:
- Neuronal acetylcholine receptor subunit alpha-9
- Protein Accession:
- Q9UGM1
- Q14CY7
- Q4W5A2
- Q9NYV2
Protein attributes for CHRNA9 Gene
- Size:
- 479 amino acids
- Molecular mass:
- 54807 Da
- Quaternary structure:
-
- Can form homo- or heterooligomeric channels in conjunction with CHRNA10 (PubMed:11752216). The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. Interacts with the alpha-conotoxon RgIA (PubMed:22774872).
- Miscellaneous:
-
- The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).
Protein Expression for CHRNA9 Gene
Post-translational modifications for CHRNA9 Gene
- N-glycosylated.
- Glycosylation at Asn57 and posLast=170170
- Modification sites at PhosphoSitePlus
Other Protein References for CHRNA9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CHRNA9
- Novus Biologicals Antibodies for CHRNA9
- Invitrogen Antibodies for CHRNA9
- antibodies-online Antibodies for CHRNA9: See all 12
- Search GeneTex for Antibodies for CHRNA9
-
Santa Cruz Biotechnology (SCBT) Antibodies for CHRNA9
Protein Products
-
OriGene Purified Proteins for CHRNA9
- Search Origene for MassSpec and Protein Over-expression Lysates for CHRNA9
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- Search GeneTex for Proteins for CHRNA9
Assay Products
No data available for DME Specific Peptides for CHRNA9 Gene
Domains & Families for CHRNA9 Gene
Gene Families for CHRNA9 Gene
- HGNC:
- IUPHAR :
Protein Domains for CHRNA9 Gene
Suggested Antigen Peptide Sequences for CHRNA9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UGM1UniProtKB/Swiss-Prot:
ACHA9_HUMAN :- Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.
- Family:
-
- Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.
Function for CHRNA9 Gene
Molecular function for CHRNA9 Gene
- UniProtKB/Swiss-Prot Function:
- Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA | -- |
| GO:0005262 | calcium channel activity | IEA | -- |
| GO:0015276 | ligand-gated ion channel activity | TAS | -- |
| GO:0022848 | acetylcholine-gated cation-selective channel activity | IDA | 25282151 |
Phenotypes for CHRNA9 Gene
- MGI mutant phenotypes for CHRNA9:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CHRNA9:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHRNA9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRNA9 gene
- Search ViGene Biosciences for CHRNA9
CRISPR Products
-
OriGene CRISPR knockouts for CHRNA9
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHRNA9
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miRNA for CHRNA9 Gene
- miRTarBase miRNAs that target CHRNA9
miRNA Products
- Search ViGene Biosciences for CHRNA9
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHRNA9
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-
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Clone Products
-
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- VectorBuilder custom plasmid, inducible vectors for CHRNA9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRNA9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CHRNA9 (Nicotinic Acetylcholine R alpha 9/CHRNA9)
Cell Line Products
-
Horizon Cell Lines for CHRNA9
-
ViGene Biosciences adenoviral particle packaged cDNA for CHRNA9 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHRNA9 Gene
Localization for CHRNA9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHRNA9 Gene
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 25282151 |
| GO:0005892 | acetylcholine-gated channel complex | IDA | 25282151 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for CHRNA9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of Nicotinic Acetylcholine Receptors | ||
| 2 | Transmission across Chemical Synapses |
.62
|
|
| 3 | Peptide ligand-binding receptors | ||
| 4 | Nanog in Mammalian ESC Pluripotency |
.48
|
|
| 5 | CREB Pathway | ||
Pathways by source for CHRNA9 Gene
7 Reactome pathways for CHRNA9 Gene
1 KEGG pathway for CHRNA9 Gene
2 Qiagen pathways for CHRNA9 Gene
Interacting Proteins for CHRNA9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006812 | cation transport | IEA | -- |
| GO:0006816 | calcium ion transport | IEA | -- |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | IGI | 18420419 |
No data available for SIGNOR curated interactions for CHRNA9 Gene
Drugs & Compounds for CHRNA9 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Nicotine | Approved | Pharma | Antagonist, antagonist, Target, agonist | 1103 | ||
| Ethanol | Approved | Pharma | Target | 2137 | ||
| Galantamine | Approved | Pharma | Target, allosteric modulator | 106 | ||
| tetraethylammonium | Experimental | Pharma | Inhibitor, Target, agonist, inhibitor | 1 | ||
| ATG003 | Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [<sup>125</sup>I]alpha-bungarotoxin |
|
|
|
|||
| [<sup>3</sup>H]alpha-bungarotoxin |
|
|
|
|||
| alpha-Bungarotoxin |
|
Antagonist | 11032-79-4 |
|
|
|
| alpha-conotoxin RgIA |
|
Antagonist |
|
|
(2) ApexBio Compounds for CHRNA9 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ACV 1 | 740980-24-9 | |
| α-Conotoxin ImI | 156467-85-5 |
Drug Products
- ApexBio compounds for CHRNA9
Transcripts for CHRNA9 Gene
mRNA/cDNA for CHRNA9 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (6) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHRNA9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHRNA9
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHRNA9
- GenScript: Design CRISPR guide RNA sequences for CHRNA9
miRNA Products
- Search ViGene Biosciences for CHRNA9
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHRNA9
- Browse OriGene Inhibitory RNA Products For CHRNA9
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRNA9 gene
Clone Products
-
OriGene ORF clones in human for CHRNA9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHRNA9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRNA9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CHRNA9 (Nicotinic Acetylcholine R alpha 9/CHRNA9)
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: |
Expression for CHRNA9 Gene
mRNA differential expression in normal tissues according to GTEx for CHRNA9 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRNA9 Gene
NURSA nuclear receptor signaling pathways regulating expression of CHRNA9 Gene:
CHRNA9SOURCE GeneReport for Unigene cluster for CHRNA9 Gene:
Hs.272278mRNA Expression by UniProt/SwissProt for CHRNA9 Gene:
Q9UGM1-ACHA9_HUMANPrimer Products
-
OriGene qPCR primer pairs and template standards for CHRNA9
-
OriGene qPCR primer pairs for CHRNA9
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRNA9 Gene
Orthologs for CHRNA9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHRNA9 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CHRNA9 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CHRNA9 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chrna9 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Chrna9 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CHRNA9 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CHRNA9 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHRNA9 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CHRNA9 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | chrna9 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | chrna9 34 35 |
|
||
| CHRNA9 (1 of 3) 35 |
|
OneToMany | |||
| chrna10a 35 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.90 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | nAcRbgr-21C 36 |
|
|
|
| nAcRbeta-21C 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | acr-17 36 |
|
|
|
| acr-22 36 |
|
|
|||
| deg-3 36 |
|
|
|||
| F18G5.4 36 |
|
|
|||
| Y73F8A.30 36 |
|
|
|||
| acr-18 36 |
|
|
|||
| C04C3.2 36 |
|
|
|||
| Y44A6E.1 36 |
|
|
|||
| Y57G11C.2 36 |
|
|
|||
| lgc-1 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany |
- Species where no ortholog for CHRNA9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CHRNA9 Gene
Paralogs for CHRNA9 Gene
(18) SIMAP similar genes for CHRNA9 Gene using alignment to 1 proteins:
Variants for CHRNA9 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000053780 | -- | 40,353,427(+) | CAGAG(A/G)TTGCA | intron-variant | |
| rs1000054751 | -- | 40,340,231(+) | TACAC(A/G)GAGCC | intron-variant | |
| rs10001509 | -- | 40,349,860(+) | CCAGA(A/G)GTTAA | intron-variant | |
| rs1000592236 | -- | 40,333,365(+) | ACTCT(C/T)GTAAT | upstream-variant-2KB | |
| rs10007267 | -- | 40,351,225(+) | tactt(A/G)ggagg | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3330900 | CNV | duplication | 20981092 |
| esv3569393 | CNV | loss | 25503493 |
| nsv1074706 | CNV | deletion | 25765185 |
| nsv1136043 | CNV | deletion | 24896259 |
| nsv1139233 | CNV | deletion | 24896259 |
Relevant External Links for CHRNA9 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA9 Gene
Disorders for CHRNA9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal recessive 25 |
|
|
| nicotine dependence, protection against |
|
|
Relevant External Links for CHRNA9
No data available for UniProtKB/Swiss-Prot and Genatlas for CHRNA9 Gene
Publications for CHRNA9 Gene
- Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PMID: 17559419) Rigbi A. … Lerer B. (Genes Brain Behav. 2008) 3 22 46 64
- A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. (PMID: 11752216) Sgard F. … Besnard F. (Mol. Pharmacol. 2002) 3 4 22 64
- Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene. (PMID: 12697997) Lustig L.R. … Peng H. (Cytogenet. Genome Res. 2002) 3 4 22 64
- Crystal structures of free and antagonist-bound states of human alpha9 nicotinic receptor extracellular domain. (PMID: 25282151) Zouridakis M. … Tzartos S.J. (Nat. Struct. Mol. Biol. 2014) 3 4 64
- Molecular basis for the differential sensitivity of rat and human I+9I+10 nAChRs to I+-conotoxin RgIA. (PMID: 22774872) Azam L. … McIntosh J.M. (J. Neurochem. 2012) 3 4 64
Products for CHRNA9 Gene
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- GenScript: Design CRISPR guide RNA sequences for CHRNA9
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- Novus Biologicals Antibodies for CHRNA9
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CHRNA9
- ViGene Biosciences adenoviral particle packaged cDNA for CHRNA9 gene
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- Search ViGene Biosciences for CHRNA9
- Santa Cruz Biotechnology (SCBT) Antibodies for CHRNA9
- Search Santa Cruz Biotechnology (SCBT) for CHRNA9 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CHRNA9
- Horizon Cell Lines for CHRNA9
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHRNA9
- VectorBuilder custom plasmid, inducible vectors for CHRNA9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRNA9
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CHRNA9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
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