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CHRNA7 Gene

protein-coding   GIFtS: 63
GCID: GC15P032322

Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal)

(Previous names: cholinergic receptor, nicotinic, alpha polypeptide 7)
  See CHRNA7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal)1 2     CHRNA7-22
Cholinergic Receptor, Nicotinic, Alpha Polypeptide 71 2     A7 Nicotinic Acetylcholine Receptor2
NACHRA72 3     Alpha 7 Neuronal Nicotinic Acetylcholine Receptor2
Acetylcholine Receptor1     Alpha-7 Nicotinic Cholinergic Receptor Subunit2
Alpha 7 (Neuronal)1     Neuronal Acetylcholine Receptor Protein, Alpha-7 Chain2
nicotinic1     Neuronal Acetylcholine Receptor Subunit Alpha-72

External Ids:    HGNC: 19601   Entrez Gene: 11392   Ensembl: ENSG000001753447   OMIM: 1185115   UniProtKB: P365443   

Export aliases for CHRNA7 gene to outside databases

Previous GC identifers: GC15M026503 GC15P025077 GC15P029901 GC15P030038 GC15P030110 GC15M008072 GC15P030877


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHRNA7 Gene:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that
mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of
homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain
followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane
domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric
channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that
are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes
an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel
across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for
juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An
evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this
gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Feb 2012)

GeneCards Summary for CHRNA7 Gene:
CHRNA7 (cholinergic receptor, nicotinic, alpha 7 (neuronal)) is a protein-coding gene. Diseases associated with CHRNA7 include schizophrenia, neurophysiologic defect in, and 15q13.3 microdeletion. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and protein homodimerization activity. An important paralog of this gene is HTR3E.

UniProtKB/Swiss-Prot: ACHA7_HUMAN, P36544
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all
subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by
alpha-bungarotoxin

summary for CHRNA7 Gene:
Alpha7 is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. In
avian tissue alpha7alpha8 heteromers also occur and an association between alpha7 and beta2 subunits has
been suggested in the mammalian brain. The alpha7 nAChR is particularly prominent in the hippocampus, where
it is found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.
Presynaptic alpha7 nAChRs are present on glutamate terminals and facilitate transmitter release in various
brain regions, including the hippocampus, cortex and ventral tegmental area. Nicotine acting at alpha7
nAChRs can enhance hippocampal LTP, and alpha7 nAChRs are associated with attentional processes and working
memory. As a consequence, alpha7 nAChRs are a therapeutic target for treating cognitive impairment, notably
in Alzheimer's disease and schizophrenia, and this has prompted the generation of alpha7 nAChR-selective
ligands. The human gene encoding the nicotinic alpha7 receptor subunit has been localized to chromosome 15
(15q13.3).

Gene Wiki entry for CHRNA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  NT_187660.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHRNA7 gene promoter:
         SRF   NF-1   SRF (504 AA)   Nkx2-5   STAT5A   NF-E2 p45   FOXL1   C/EBPalpha   AREB6   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRNA7 promoter sequence
   Search Chromatin IP Primers for CHRNA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRNA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q13.3   HGNC cytogenetic band: 15q13.3

CHRNA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRNA7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P032322:  view genomic region     (about GC identifiers)

Start:
32,322,691 bp from pter      End:
32,464,722 bp from pter
Size:
142,032 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACHA7_HUMAN, P36544 (See protein sequence)
Recommended Name: Neuronal acetylcholine receptor subunit alpha-7 precursor  
Size: 502 amino acids; 56449 Da
Subunit: Homopentamer. Interacts with RIC3; which is required for proper folding and assembly
Mass spectrometry: Mass=54157.68; Method=MALDI; Range=23-502; Source=PubMed:11840567;
1 PDB 3D structure from and Proteopedia for CHRNA7:
2MAW (3D)    
Secondary accessions: A8K7Q4 B4DFS0 Q15826 Q8IUZ4 Q96RH2 Q99555 Q9BXH0
Alternative splicing: 3 isoforms:  P36544-1   P36544-2   P36544-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHRNA7: NX_P36544

Explore proteomics data for CHRNA7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn46, Asn90, Asn133
  • Modification sites at PhosphoSitePlus

  • See CHRNA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000737.1  NP_001177384.1  

    ENSEMBL proteins: 
     ENSP00000407546   ENSP00000303727   ENSP00000399087   ENSP00000405989  
    Reactome Protein details: P36544

    CHRNA7 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CHRNA7
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    Novus Biologicals CHRNA7 Protein
    Novus Biologicals CHRNA7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CHRNA7 

    CHRNA7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CHRNA7
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    Abcam antibodies for CHRNA7 (P36544, Q8IUZ4)
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    LSBio Antibodies in human, mouse, rat for CHRNA7

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for CHRNA7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHRN: Ligand-gated ion channels / Acetylcholine receptors, nicotinic
    CHR: Cholinergic receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha7
    Nicotinic acetylcholine receptors

    Selected InterPro protein domains (see all 6):
     IPR027361 Acetylcholine_rcpt_TM
     IPR002394 Nicotinic_acetylcholine_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry P36544

    ProtoNet protein and cluster: P36544

    2 Blocks protein domains:
    IPB002394 Nicotinic acetylcholine receptor signature
    IPB006201 Neurotransmitter-gated ion-channel


    UniProtKB/Swiss-Prot: ACHA7_HUMAN, P36544
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1)
    subfamily. Alpha-7/CHRNA7 sub-subfamily


    Find genes that share domains with CHRNA7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACHA7_HUMAN, P36544
    Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all
    subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by
    alpha-bungarotoxin

         Genatlas biochemistry entry for CHRNA7:
    cholinergic receptor,nicotinic,alpha 7 polypeptide (alpha-bungarotoxin binding),brain,partially duplicated

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IPI10681545
    GO:0004889acetylcholine-activated cation-selective channel activity IDA12508119
    GO:0005230extracellular ligand-gated ion channel activity ----
    GO:0005515protein binding ----
    GO:0008144drug binding IEA--
         
    Find genes that share ontologies with CHRNA7           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chrna7):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  reproductive system  respiratory system 

    Find genes that share phenotypes with CHRNA7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Chrna7tm1Bay for CHRNA7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHRNA7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHRNA7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHRNA7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHRNA7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHRNA7:
    hsa-mir-335-5p (MIRT016843)

    Block miRNA regulation of human, mouse, rat CHRNA7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHRNA7 (see all 9):
    hsa-miR-146a* hsa-miR-576-5p hsa-miR-499-5p hsa-miR-370 hsa-miR-2355-3p hsa-miR-4263 hsa-miR-3652 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidCHRNA7 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CHRNA7

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CHRNA7

    Clone
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    OriGene ORF clones in mouse, rat for CHRNA7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CHRNA7 (NM_000746)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRNA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNA7

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACHA7_HUMAN, P36544: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005892acetylcholine-gated channel complex IDA8906617
    GO:0009897external side of plasma membrane IEA--
    GO:0014069postsynaptic density IEA--

    Find genes that share ontologies with CHRNA7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHRNA7 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of Nicotinic Acetylcholine Receptors
    Activation of Nicotinic Acetylcholine Receptors
    Highly calcium permeable postsynaptic nicotinic acetylcholine receptors0.00
    Acetylcholine Binding And Downstream Events0.00
    Postsynaptic nicotinic acetylcholine receptors0.00
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48


    Find genes that share SuperPaths with CHRNA7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CHRNA7
        eNOS Signaling
    Intracellular Calcium Signaling

    1 BioSystems Pathway for CHRNA7
        SIDS Susceptibility Pathways

    1 Reactome Pathway for CHRNA7
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

    1 PharmGKB Pathway for CHRNA7
        Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

    5 Kegg Pathways  (Kegg details for CHRNA7):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Cholinergic synapse
    Nicotine addiction
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Array including CHRNA7: 
              Neurotransmitter Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CHRNA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for CHRNA7 (P365443 ENSP000003037274) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY6O433063, ENSP000003114054I2D: score=2 STRING: ENSP00000311405
    APPP050673, ENSP000002849814I2D: score=2 STRING: ENSP00000284981
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    CHRNA2ENSP000002401324STRING: ENSP00000240132
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA10771023
    GO:0001666response to hypoxia IDA12189247
    GO:0001988positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure IEA--
    GO:0006810transport ----
    GO:0006811ion transport NAS8906617

    Find genes that share ontologies with CHRNA7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CHRNA7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NS 1738Positive allosteric modulator of alpha7 nAChR; active in vivo[501684-93-1]
    alpha-Bungarotoxinalpha7 subtype-selective nAChR antagonist[11032-79-4]
    Methyllycaconitine citratealpha7 neuronal nicotinic receptor antagonist[21019-30-7]
    PNU 282987Selective alpha7 nAChR agonist[123464-89-1]
    PNU 120596Positive allosteric modulator of alpha7 nAChR; active in vivo[501925-31-1]

    Selected DrugBank Compounds for CHRNA7 (see all 20)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Galantamine(-)-Galanthamine (see all 3)357-70-0targetallosteric modulator12137632 11129124 12481195 20480924 12177686 10971048
    NicotineL-Nicotine (see all 2)54-11-5targetagonist19560048 20081230 16754836 20400469 11006350 17360707
    Amobarbital-- 57-43-2targetantagonist11264449 16248797 10487207
    Aprobarbital-- 77-02-1targetantagonist11264449 16248797 10487207
    Barbital-- 57-44-3targetantagonist11264449 16248797 10487207
    Barbituric acid derivative-- --targetantagonist11264449 16248797 10487207
    ButabarbitalButabarbital Sodium (see all 8)125-40-6targetantagonist11264449 16248797 10487207
    ButalbitalAllylbarbital (see all 2)77-26-9targetantagonist11264449 16248797 10487207
    Butethal5-Butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (see all 10)77-28-1targetantagonist11264449 16248797 10487207
    HeptabarbitalHeptabarb (see all 9)509-86-4targetantagonist11264449 16248797 10487207

    Selected IUPHAR Ligands for CHRNA7 (alpha7) (see all 21)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]epibatidine
    NoneNone12.22--
    [3H]A-585539
    NoneNone10.1517959745
    [3H]AZ11637326
    NoneNone9.6420674564
    [3H]alpha-bungarotoxin
    NoneNone9.15 - 8.3--
    [125I]alpha-bungarotoxin
    NoneNone9.15 - 8.3--
    mecamylamine
    Channel blockerNone4.81--
    LY2087101
    Allosteric regulatorPositive4.8116738207
    PHA-709829
    AgonistFull agonist4.8118490160
    alpha-bungarotoxin
    AntagonistAntagonist4.81--
    4BP-TQS
    AgonistFull agonist4.8121436053

    Selected Novoseek inferred chemical compound relationships for CHRNA7 gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methyllycaconitine 94.6 25 20377277 (2), 15469877 (1), 10619630 (1), 10987839 (1) (see all 17)
    alpha-bungarotoxin 92.9 21 12614199 (2), 11207427 (2), 10987839 (1), 17254563 (1) (see all 18)
    3 (2,4 dimethoxybenzylidene)anabaseine 91.5 4 19956085 (1), 16754836 (1)
    dmxba 86.9 1 10942043 (1)
    nicotine 84.6 60 16846598 (6), 17254563 (3), 10942036 (2), 10686080 (1) (see all 44)
    5-hydroxyindole 83.3 2 12243767 (1)
    dihydro-beta-erythroidine 83 8 15469877 (1), 19728991 (1), 10082212 (1), 11906789 (1) (see all 6)
    epibatidine 77.5 3 15590768 (1), 19954975 (1), 15588622 (1)
    acetylcholine 73.2 39 16506783 (3), 17522313 (2), 14581202 (1), 15357617 (1) (see all 32)
    mecamylamine 72.5 5 10619630 (1), 17254563 (1), 11600102 (1), 17016705 (1) (see all 5)



    Find genes that share compounds with CHRNA7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHRNA7 gene (2 alternative transcripts): 
    NM_000746.5  NM_001190455.2  

    Unigene Cluster for CHRNA7:

    Cholinergic receptor, nicotinic, alpha 7 (neuronal)
    Hs.511772  [show with all ESTs]
    Unigene Representative Sequence: NM_001190455
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454250(uc010bad.2 uc010bab.2 uc010bac.2 uc010bae.2 uc010bag.1 uc010bah.1 uc010bai.1)
    ENST00000306901(uc001zft.3 uc021sic.1 uc010baf.3 uc010bak.3)
    ENST00000437966 ENST00000455693(uc010baj.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat CHRNA7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHRNA7 (see all 9):
    hsa-miR-146a* hsa-miR-576-5p hsa-miR-499-5p hsa-miR-370 hsa-miR-2355-3p hsa-miR-4263 hsa-miR-3652 hsa-miR-1291
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    GenScript: all cDNA clones in your preferred vector (see all 2): CHRNA7 (NM_000746)
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      QuantiFast Probe-based Assays in human, mouse, rat CHRNA7

    Additional mRNA sequence: 

    AF385585.1 AJ586911.1 AK292069.1 AK294229.1 AY909581.1 EF405802.1 EF405803.1 EF405804.1 
    EF405805.1 EF405806.1 EF405807.1 EF405808.1 EF405809.1 EF405810.1 EF405811.1 EF405812.1 
    EF405813.1 EF405814.1 EF405815.1 EF405816.1 EF405817.1 EF405818.1 EF405819.1 EF405820.1 
    L25827.1 NR_046324.1 U40583.1 U62436.1 X70297.1 Y08420.1 Z23141.1 

    5 DOTS entries:

    DT.100778392  DT.100025592  DT.97837952  DT.100778391  DT.100778393 

    Selected AceView cDNA sequences (see all 71):

    BU149265 AI791902 BF507825 NM_000746 AA639641 AA301331 CR608436 BU680930 
    AA897701 BI963064 BX282644 CR605947 BC037571 CR594008 AI208142 BX090309 
    BX422848 CR620753 BM451308 AL519942 CB160887 AU253238 BV191931 CK903362 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHRNA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHRNA7 Expression
    About this image


    CHRNA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CHRNA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHRNA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511772
        Pathway & Disease-focused RT2 Profiler PCR Array including CHRNA7: 
              Neurotransmitter Receptors in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CHRNA7
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    QuantiFast Probe-based Assays in human, mouse, rat CHRNA7
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHRNA7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrna71 , 5 cholinergic receptor, nicotinic, alpha polypeptide more1, 5 88.06(n)1
    93.96(a)1
      7 (34.47 cM)5
    114411  NM_007390.31  NP_031416.31 
     630986925 
    chicken
    (Gallus gallus)
    Aves CHRNA71 cholinergic receptor, nicotinic, alpha 7 (neuronal) 77.64(n)
    90.91(a)
      374001  NM_204181.2  NP_989512.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    83(a)
    1 → many
    GL343486.1(221428-260641)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004936111 neuronal acetylcholine receptor subunit alpha-7-like 73.6(n)
    85.25(a)
      100493611  XM_002937671.2  XP_002937717.2 
    zebrafish
    (Danio rerio)
    Actinopterygii chrna72 cholinergic receptor, nicotinic, alpha polypeptide more 76.56(n)   394199  AY247962.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nAcRalpha-18C3
    nAcRalpha-34E1
    nicotinic acetylcholine-activated
    cation-selective more3
    nicotinic Acetylcholine Receptor alpha 34E1
    60(a)
    (best of 6)3
    55.28(n)1
    51.25(a)1
      348261  NM_001259098.21  NP_001246027.11 
    worm
    (Caenorhabditis elegans)
    Secernentea acr-193
    acr-161
    nicotinic acetylcholine receptor3
    acr-161
    49(a)
    (best of 21)3
    49.21(n)1
    45.57(a)1
      I(9039491-9044719)3
    1792351  NM_072806.41  NP_505207.11 


    ENSEMBL Gene Tree for CHRNA7 (if available)
    TreeFam Gene Tree for CHRNA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHRNA7 gene
    HTR3E2  HTR3A2  CHRNA102  CHRNA92  HTR3B2  ZACN2  CHRFAM7A2  HTR3C2  
    HTR3D2  
    17 SIMAP similar genes for CHRNA7 using alignment to 3 protein entries:     ACHA7_HUMAN (see all proteins):
    CHRFAM7A    CHRNA7-2    CHRNA2    CHRNA4    CHRNB4    CHRNA9
    CHRNA1    CHRNA3    CHRNA6    CHRNB2    CHRNA10    CHRNB1
    CHRNB3    CHRND    CHRNA5    CHRNG    CHRNE

    Find genes that share paralogs with CHRNA7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHRNA7 (see all 3062)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs791565891,2
    C,F--12360129(+) ACCTAC/ACTATG 5 -- us2k11Minor allele frequency- A:0.02NA 120
    rs727135271,2
    C,F--12360153(+) TGAAGT/CTTATT 5 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1161782141,2
    F--12360258(+) ATTTAC/TGAATT 5 -- us2k11Minor allele frequency- T:0.03WA 118
    rs30874541,2
    C,F,A,H--12360383(-) TTATTA/C/G/
            
    ATTTT
    5 -- us2k1 tfbs312NA CSA WA EA 551
    rs1166726821,2
    F--12360421(+) CTTCTA/GGAAGG 5 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1920901821,2
    --12360607(+) CCCCTA/GTAGAT 6 -- us2k10--------
    rs1834906511,2
    --12360627(+) ATCAAG/TTGCCT 6 -- us2k10--------
    rs1422056531,2
    --12360629(+) CAAGTA/GCCTGC 6 -- us2k10--------
    rs1458518231,2
    C--12360700(+) GCACGC/TCTGTC 6 -- us2k10--------
    rs64941651,2
    C,F,A,H--12360702(+) ACGCCT/GGTCTG 6 -- us2k121Minor allele frequency- G:0.09NS EA NA WA 2588

    HapMap Linkage Disequilibrium report for CHRNA7 (32322691 - 32464722 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CHRNA7 (see all 46):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749539CNV Deletion23290073
    esv2749540CNV Deletion23290073
    esv2668191CNV Deletion23128226
    esv2749542CNV Deletion23290073
    dgv11e196CNV Duplication17116639
    dgv2318n71CNV Loss21882294
    dgv2317n71CNV Loss21882294
    nsv819078CNV Loss19587683
    dgv2322n71CNV Loss21882294
    nsv469726CNV Loss16826518

    Human Gene Mutation Database (HGMD): CHRNA7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHRNA7
    DNA2.0 Custom Variant and Variant Library Synthesis for CHRNA7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118511    OMIM disorders: --

    6 diseases for CHRNA7:    
    About MalaCards
    schizophrenia, neurophysiologic defect in    15q13.3 microdeletion    intermittent explosive disorder    juvenile myoclonic epilepsy
    rasmussen encephalitis    schizophrenia

    5 diseases from the University of Copenhagen DISEASES database for CHRNA7:
    Schizophrenia     Autistic disorder     Nicotine dependence     Intermittent explosive disorder
    Schizoaffective disorder

    Find genes that share disorders with CHRNA7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CHRNA7 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 74.9 132 19181484 (6), 16889592 (5), 16134405 (4), 17113175 (4) (see all 60)
    alzheimers disease 67.8 47 11958863 (2), 17493709 (2), 18078695 (2), 19433665 (2) (see all 38)
    cognitive deficit 59.9 10 17094961 (2), 17898229 (1), 17504249 (1), 17601496 (1) (see all 9)
    senile plaques 54.2 4 11958863 (1), 19587288 (1), 15698636 (1), 10681545 (1)
    cognitive dysfunction 50.4 4 19853005 (1), 17349863 (1), 17470817 (1)
    neurodegeneration 39.6 4 18180036 (2), 16842101 (1), 15228589 (1)
    neurodegenerative diseases 27 2 19287501 (1)
    brain diseases 23.2 4 11958863 (1), 19726654 (1), 10681545 (1), 15858066 (1)
    cognitive disorder 22 1 20043678 (1)
    psychotic 19.1 1 16889592 (1)

    Genetic Association Database (GAD): CHRNA7
    Human Genome Epidemiology (HuGE) Navigator: CHRNA7 (56 documents)

    Export disorders for CHRNA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHRNA7 gene, integrated from 10 sources (see all 482):
    (articles sorted by number of sources associating them with CHRNA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localization of the human alpha 7- nicotinic receptor subunit gene (CHRNA7). (PubMed id 8188270)1, 2, 3 Chini B....Heinemann S.F. (Genomics 1994)
    2. Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. (PubMed id 19181484)1, 4, 9 Stephens S.H....Leonard S. (Schizophr. Res. 2009)
    3. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. (PubMed id 12470124)1, 4, 9 Leonard S....Freedman R. (Arch. Gen. Psychiatry 2002)
    4. Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease. (PubMed id 18057084)1, 4, 9 Carson R....Ritchie C.W. (J. Med. Genet. 2008)
    5. A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PubMed id 11829490)1, 2, 9 Riley B.... Makoff A. (Genomics 2002)
    6. Evidence for linkage disequilibrium between the alpha 7-nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families. (PubMed id 11803513)1, 4, 9 Xu J....Pato C.N. (Am. J. Med. Genet. 2001)
    7. APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease. (PubMed id 18078695)1, 4, 9 Barabash A....Cabranes J.A. (Neurobiol. Aging 2009)
    8. [The transmission disequilibrium analysis between neuronal nicotinic acetylcholine receptor alpha 7 subunit gene polymorphisms and schizophrenia]. (PubMed id 18393235)1, 4, 9 Peng Z.Z....Jiang T.Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    9. Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia. (PubMed id 17113175)1, 4, 9 Iwata Y....Collier D. (Neurosci. Res. 2007)
    10. Population-based and family-based association studies of an (AC)n dinucleotide repeat in alpha-7 nicotinic receptor subunit gene and schizophrenia. (PubMed id 16563701)1, 4, 9 Fan J.B....He L. (Schizophr. Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1139 HGNC: 1960 AceView: CHRNA7 Ensembl:ENSG00000175344 euGenes: HUgn1139
    ECgene: CHRNA7 Kegg: 1139 H-InvDB: CHRNA7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHRNA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHRNA7 gene:
    Search GeneIP for patents involving CHRNA7

    Licensable Technologies for CHRNA7 gene:
    Weizmann Institute:Diagnosis and Follow-up of Schizophrenia
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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