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Aliases for CHRNA7 Gene

Aliases for CHRNA7 Gene

  • Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal) 2 3
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 7 2 3
  • NACHRA7 3 4
  • Neuronal Acetylcholine Receptor Protein, Alpha-7 Chain 3
  • Alpha 7 Neuronal Nicotinic Acetylcholine Receptor 3
  • Neuronal Acetylcholine Receptor Subunit Alpha-7 3
  • Alpha-7 Nicotinic Cholinergic Receptor Subunit 3
  • A7 Nicotinic Acetylcholine Receptor 3
  • Acetylcholine Receptor 2
  • Alpha 7 (Neuronal) 2
  • Nicotinic 2
  • CHRNA7-2 3

External Ids for CHRNA7 Gene

Previous GeneCards Identifiers for CHRNA7 Gene

  • GC15M026503
  • GC15P025077
  • GC15P029901
  • GC15P030038
  • GC15P030110
  • GC15P032322
  • GC15M008072
  • GC15P030877

Summaries for CHRNA7 Gene

Entrez Gene Summary for CHRNA7 Gene

  • The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

GeneCards Summary for CHRNA7 Gene

CHRNA7 (Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal)) is a Protein Coding gene. Diseases associated with CHRNA7 include 15q13.3 microdeletion and intermittent explosive disorder. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein homodimerization activity and acetylcholine-activated cation-selective channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for CHRNA7 Gene

  • After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin

Tocris Summary for CHRNA7 Gene

  • Alpha7 is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. In avian tissue alpha7alpha8 heteromers also occur and an association between alpha7 and beta2 subunits has been suggested in the mammalian brain. The alpha7 nAChR is particularly prominent in the hippocampus, where it is found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones. Presynaptic alpha7 nAChRs are present on glutamate terminals and facilitate transmitter release in various brain regions, including the hippocampus, cortex and ventral tegmental area. Nicotine acting at alpha7 nAChRs can enhance hippocampal LTP, and alpha7 nAChRs are associated with attentional processes and working memory. As a consequence, alpha7 nAChRs are a therapeutic target for treating cognitive impairment, notably in Alzheimer's disease and schizophrenia, and this has prompted the generation of alpha7 nAChR-selective ligands. The human gene encoding the nicotinic alpha7 receptor subunit has been localized to chromosome 15 (15q13.3).

Gene Wiki entry for CHRNA7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA7 Gene

Genomics for CHRNA7 Gene

Regulatory Elements for CHRNA7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHRNA7 Gene

Start:
32,030,483 bp from pter
End:
32,172,521 bp from pter
Size:
142,039 bases
Orientation:
Plus strand

Genomic View for CHRNA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRNA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA7 Gene

Proteins for CHRNA7 Gene

  • Protein details for CHRNA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36544-ACHA7_HUMAN
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-7
    Protein Accession:
    P36544
    Secondary Accessions:
    • A8K7Q4
    • B4DFS0
    • Q15826
    • Q8IUZ4
    • Q96RH2
    • Q99555
    • Q9BXH0

    Protein attributes for CHRNA7 Gene

    Size:
    502 amino acids
    Molecular mass:
    56449 Da
    Quaternary structure:
    • Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.

    Three dimensional structures from OCA and Proteopedia for CHRNA7 Gene

    Alternative splice isoforms for CHRNA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHRNA7 Gene

Proteomics data for CHRNA7 Gene at MOPED

Post-translational modifications for CHRNA7 Gene

  • Glycosylation at Asn46, Asn90, and Asn133
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNA7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHRNA7 Gene

Domains for CHRNA7 Gene

Gene Families for CHRNA7 Gene

HGNC:
  • CHR :Cholinergic receptors
  • CHRN :Ligand-gated ion channels / Acetylcholine receptors, nicotinic
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P36544

UniProtKB/Swiss-Prot:

ACHA7_HUMAN :
  • P36544
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
genes like me logo Genes that share domains with CHRNA7: view

Function for CHRNA7 Gene

Molecular function for CHRNA7 Gene

GENATLAS Biochemistry: cholinergic receptor,nicotinic,alpha 7 polypeptide (alpha-bungarotoxin binding),brain,partially duplicated
UniProtKB/Swiss-Prot Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin

Gene Ontology (GO) - Molecular Function for CHRNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IPI 10681545
GO:0004889 acetylcholine-activated cation-selective channel activity IDA 12508119
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0015464 acetylcholine receptor activity IDA 8906617
GO:0015643 toxic substance binding IDA 12508119
genes like me logo Genes that share ontologies with CHRNA7: view
genes like me logo Genes that share phenotypes with CHRNA7: view

Animal Models for CHRNA7 Gene

MGI Knock Outs for CHRNA7:

Animal Model Products

CRISPR Products

miRNA for CHRNA7 Gene

miRTarBase miRNAs that target CHRNA7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNA7

Clone Products

  • R&D Systems cDNA Clones for CHRNA7 (Nicotinic Acetylcholine R alpha 7/CHRNA7)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CHRNA7 Gene

Localization for CHRNA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA7 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRNA7 Gene COMPARTMENTS Subcellular localization image for CHRNA7 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHRNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005892 acetylcholine-gated channel complex IDA 8906617
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 8145738
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CHRNA7: view

Pathways for CHRNA7 Gene

genes like me logo Genes that share pathways with CHRNA7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHRNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 10771023
GO:0001666 response to hypoxia IDA 12189247
GO:0006810 transport --
GO:0006811 ion transport NAS 8906617
GO:0006816 calcium ion transport IMP 10771023
genes like me logo Genes that share ontologies with CHRNA7: view

Compounds for CHRNA7 Gene

(5) Tocris Compounds for CHRNA7 Gene

Compound Action Cas Number
alpha-Bungarotoxin alpha7 subtype-selective nAChR antagonist [11032-79-4]
AR-R 17779 hydrochloride alpha7-selective agonist [178419-42-6]
Methyllycaconitine citrate alpha7 neuronal nicotinic receptor antagonist [112825-05-5]
PNU 120596 Positive allosteric modulator of alpha7 nAChR; active in vivo [501925-31-1]
PNU 282987 Selective alpha7 nAChR agonist [123464-89-1]

(20) Drugbank Compounds for CHRNA7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Amobarbital
57-43-2 target antagonist
Aprobarbital
77-02-1 target antagonist
Barbital
57-44-3 target antagonist
Barbituric acid derivative
target antagonist
Butabarbital
  • Butabarbital Sodium
125-40-6 target antagonist

(21) IUPHAR Ligand for CHRNA7 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]A-585539 None None 10.15
[3H]epibatidine None None 9.64
[3H]AZ11637326 None None 9.64
mecamylamine Channel blocker None 6.41
[3H]alpha-bungarotoxin None None
[125I]alpha-bungarotoxin None None
LY2087101 Allosteric regulator Positive
PHA-709829 Agonist Full agonist
alpha-bungarotoxin Antagonist Antagonist
4BP-TQS Agonist Full agonist
methyllycaconitine Antagonist Antagonist
PNU-282987 Agonist Full agonist
TC-5619 Agonist Full agonist
NS1738 Channel blocker None
A-582941 Agonist Full agonist
alpha-conotoxin ImI Antagonist Antagonist
A-867744 Channel blocker None
alpha-conotoxin ArIB Antagonist Antagonist
PNU-120596 Allosteric regulator Positive
PHA-543613 Agonist Full agonist
JNJ1930942 Allosteric regulator Positive

(52) Novoseek inferred chemical compound relationships for CHRNA7 Gene

Compound -log(P) Hits PubMed IDs
methyllycaconitine 94.6 18
alpha-bungarotoxin 92.9 20
3 (2,4 dimethoxybenzylidene)anabaseine 91.5 2
dmxba 86.9 1
nicotine 84.6 52
genes like me logo Genes that share compounds with CHRNA7: view

Transcripts for CHRNA7 Gene

Unigene Clusters for CHRNA7 Gene

Cholinergic receptor, nicotinic, alpha 7 (neuronal):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNA7

Clone Products

  • R&D Systems cDNA Clones for CHRNA7 (Nicotinic Acetylcholine R alpha 7/CHRNA7)

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA7 Gene

No ASD Table

Relevant External Links for CHRNA7 Gene

GeneLoc Exon Structure for
CHRNA7
ECgene alternative splicing isoforms for
CHRNA7

Expression for CHRNA7 Gene

mRNA expression in normal human tissues for CHRNA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CHRNA7 Gene Hs.511772

genes like me logo Genes that share expressions with CHRNA7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for CHRNA7 Gene

Orthologs for CHRNA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRNA7 35
  • 99.27 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CHRNA7 35
  • 87.93 (n)
  • 94.57 (a)
dog
(Canis familiaris)
Mammalia CHRNA7 35
  • 91.18 (n)
  • 97.17 (a)
CHRNA7 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrna7 35
  • 88.06 (n)
  • 93.96 (a)
Chrna7 16
Chrna7 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Chrna7 35
  • 87.59 (n)
  • 93.96 (a)
chicken
(Gallus gallus)
Aves CHRNA7 35
  • 77.64 (n)
  • 90.91 (a)
CHRNA7 36
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493611 35
  • 73.6 (n)
  • 85.25 (a)
zebrafish
(Danio rerio)
Actinopterygii BX255960.1 36
  • 20 (a)
ManyToMany
CABZ01069081.1 36
  • 74 (a)
ManyToMany
CABZ01073083.1 36
  • 19 (a)
ManyToMany
CABZ01088685.1 36
  • 85 (a)
ManyToMany
chrna7 35
  • 71.53 (n)
  • 78.5 (a)
chrna7 36
  • 75 (a)
ManyToMany
si:ch211-256e16.6 36
  • 21 (a)
ManyToMany
si:ch211-39a7.1 36
  • 58 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008588 35
  • 55.21 (n)
  • 50.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta gfA 36
  • 43 (a)
ManyToMany
nAcRalpha-30D 36
  • 45 (a)
ManyToMany
nAcRalpha-34E 35
  • 55.28 (n)
  • 51.25 (a)
nAcRalpha-34E 36
  • 30 (a)
ManyToMany
nAcRalpha-96Aa 37
  • 46 (a)
nAcRalpha-96Ab 37
  • 37 (a)
nAcRalpha-30D 37
  • 50 (a)
nAcRalpha-18C 37
  • 60 (a)
nAcRalpha-34E 37
  • 56 (a)
nAcRalpha-7E 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea acr-10 36
  • 31 (a)
ManyToMany
acr-11 36
  • 41 (a)
ManyToMany
acr-14 36
  • 33 (a)
ManyToMany
acr-15 36
  • 34 (a)
ManyToMany
acr-16 35
  • 49.21 (n)
  • 45.57 (a)
acr-16 36
  • 44 (a)
ManyToMany
acr-17 36
  • 25 (a)
ManyToMany
acr-18 36
  • 25 (a)
ManyToMany
acr-19 36
  • 41 (a)
ManyToMany
acr-20 36
  • 23 (a)
ManyToMany
acr-21 36
  • 33 (a)
ManyToMany
acr-23 36
  • 23 (a)
ManyToMany
acr-24 36
  • 23 (a)
ManyToMany
acr-25 36
  • 33 (a)
ManyToMany
acr-5 36
  • 21 (a)
ManyToMany
acr-7 36
  • 33 (a)
ManyToMany
acr-9 36
  • 36 (a)
ManyToMany
deg-3 36
  • 25 (a)
ManyToMany
des-2 36
  • 24 (a)
ManyToMany
eat-2 36
  • 36 (a)
ManyToMany
lgc-10 36
  • 21 (a)
ManyToMany
lgc-11 36
  • 24 (a)
ManyToMany
lgc-12 36
  • 25 (a)
ManyToMany
lgc-13 36
  • 18 (a)
ManyToMany
lgc-14 36
  • 18 (a)
ManyToMany
lgc-15 36
  • 17 (a)
ManyToMany
lgc-16 36
  • 19 (a)
ManyToMany
lgc-17 36
  • 19 (a)
ManyToMany
lgc-18 36
  • 19 (a)
ManyToMany
lgc-19 36
  • 17 (a)
ManyToMany
lgc-29 36
  • 17 (a)
ManyToMany
lgc-30 36
  • 18 (a)
ManyToMany
lgc-31 36
  • 17 (a)
ManyToMany
lgc-4 36
  • 25 (a)
ManyToMany
lgc-6 36
  • 21 (a)
ManyToMany
lgc-7 36
  • 23 (a)
ManyToMany
lgc-8 36
  • 23 (a)
ManyToMany
lgc-9 36
  • 23 (a)
ManyToMany
pbo-5 36
  • 21 (a)
ManyToMany
pbo-6 36
  • 22 (a)
ManyToMany
deg-3 37
  • 29 (a)
Y57G11C.2 37
  • 28 (a)
acr-10 37
  • 43 (a)
acr-5 37
  • 31 (a)
C04C3.2 37
  • 28 (a)
acr-7 37
  • 37 (a)
acr-15 37
  • 33 (a)
acr-19 37
  • 49 (a)
acr-12 37
  • 33 (a)
Y73F8A.30 37
  • 36 (a)
acr-14 37
  • 33 (a)
acr-18 37
  • 30 (a)
unc-29 37
  • 33 (a)
acr-11 37
  • 40 (a)
acr-9 37
  • 38 (a)
F18G5.4 37
  • 36 (a)
acr-22 37
  • 30 (a)
acr-16 37
  • 44 (a)
ZK973.5 37
  • 30 (a)
acr-17 37
  • 32 (a)
acr-8 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for CHRNA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA7 Gene

ENSEMBL:
Gene Tree for CHRNA7 (if available)
TreeFam:
Gene Tree for CHRNA7 (if available)

Paralogs for CHRNA7 Gene

Paralogs for CHRNA7 Gene

Selected SIMAP similar genes for CHRNA7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHRNA7: view

Variants for CHRNA7 Gene

Sequence variations from dbSNP and Humsavar for CHRNA7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs286095 -- 32,166,460(+) CTGCA(A/G)TGAAA intron-variant
rs286097 -- 32,167,436(+) CTGAA(C/G)TGCTT intron-variant
rs374853 -- 32,157,486(-) GCAAA(C/T)GGAAT intron-variant
rs378746 -- 32,164,055(-) CATTC(C/T)GTTTC intron-variant
rs404783 -- 32,161,260(+) CCCTG(C/T)ACCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHRNA7 Gene

Variant ID Type Subtype PubMed ID
dgv723e1 CNV Complex 17122850
dgv11e196 CNV Duplication 17116639
dgv2309n71 CNV Gain 21882294
dgv109e55 CNV Gain 17911159
nsv9237 CNV Gain+Loss 18304495
dgv724e1 CNV Complex 17122850
nsv428302 CNV Gain+Loss 18775914
esv33337 CNV Gain+Loss 17666407
dgv2310n71 CNV Gain 21882294
dgv306n27 CNV Gain 19166990
nsv471234 CNV Gain 18288195
nsv817680 CNV Gain 17921354
nsv517740 CNV Gain+Loss 19592680
nsv903860 CNV Loss 21882294
nsv821680 CNV Gain 15273396
nsv903877 CNV Gain 21882294
dgv2312n71 CNV Gain 21882294
dgv725e1 CNV Complex 17122850
nsv469870 CNV Gain 16826518
nsv471680 CNV Gain+Loss 15918152
dgv2314n71 CNV Gain 21882294
dgv2315n71 CNV Gain 21882294
nsv832956 CNV Gain 17160897
dgv2316n71 CNV Gain 21882294
nsv903902 CNV Gain 21882294
nsv819078 CNV Loss 19587683
esv2749539 CNV Deletion 23290073
esv2749540 CNV Deletion 23290073
esv2749542 CNV Deletion 23290073
esv2668191 CNV Deletion 23128226
dgv308n27 CNV Gain 19166990
nsv471681 CNV Gain+Loss 15918152
nsv903903 CNV Loss 21882294
dgv726e1 CNV Complex 17122850
dgv727e1 CNV Complex 17122850
dgv728e1 CNV Complex 17122850
nsv469726 CNV Loss 16826518
dgv2317n71 CNV Loss 21882294
dgv2318n71 CNV Loss 21882294
dgv2319n71 CNV Gain+Loss 21882294
dgv2320n71 CNV Gain+Loss 21882294
dgv2321n71 CNV Loss 21882294
esv25982 CNV Gain+Loss 19812545
nsv9238 CNV Gain+Loss 18304495
nsv903921 CNV Gain 21882294
dgv2322n71 CNV Loss 21882294

Relevant External Links for CHRNA7 Gene

HapMap Linkage Disequilibrium report
CHRNA7
Human Gene Mutation Database (HGMD)
CHRNA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA7 Gene

Disorders for CHRNA7 Gene

(27) Novoseek inferred disease relationships for CHRNA7 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 74.9 99
alzheimers disease 67.8 45
cognitive deficit 59.9 10
senile plaques 54.2 4
cognitive dysfunction 50.4 3

Relevant External Links for CHRNA7

Genetic Association Database (GAD)
CHRNA7
Human Genome Epidemiology (HuGE) Navigator
CHRNA7
genes like me logo Genes that share disorders with CHRNA7: view

No data available for UniProtKB/Swiss-Prot for CHRNA7 Gene

Publications for CHRNA7 Gene

  1. Association analysis of the partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant and Alzheimer's disease. (PMID: 11455129) Liou Y.J. … Tsai S.J. (Dement Geriatr Cogn Disord 2001) 3 23 48
  2. Evidence for linkage disequilibrium between the alpha 7-nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families. (PMID: 11803513) Xu J. … Pato C.N. (Am. J. Med. Genet. 2001) 3 23 48
  3. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. (PMID: 12470124) Leonard S. … Freedman R. (Arch. Gen. Psychiatry 2002) 3 23 48
  4. Association study of the human partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant with bipolar disorder. (PMID: 14729237) Hong C.J. … Tsai S.J. (Neurosci. Lett. 2004) 3 23 48
  5. Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects. (PMID: 14582144) Gault J. … Leonard S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 23 48

Products for CHRNA7 Gene

Sources for CHRNA7 Gene

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