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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHRNA7 Gene

protein-coding   GIFtS: 62
GCID: GC15P032322

Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal)

(Previous names: cholinergic receptor, nicotinic, alpha polypeptide 7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal)1 2     CHRNA7-22
Cholinergic Receptor, Nicotinic, Alpha Polypeptide 71 2     A7 Nicotinic Acetylcholine Receptor2
NACHRA72 3     Alpha 7 Neuronal Nicotinic Acetylcholine Receptor2
Acetylcholine Receptor1     Alpha-7 Nicotinic Cholinergic Receptor Subunit2
Alpha 7 (Neuronal)1     Neuronal Acetylcholine Receptor Protein, Alpha-7 Chain2
nicotinic1     Neuronal Acetylcholine Receptor Subunit Alpha-72

External Ids:    HGNC: 19601   Entrez Gene: 11392   Ensembl: ENSG000001753447   OMIM: 1185115   UniProtKB: P365443   

Export aliases for CHRNA7 gene to outside databases

Previous GC identifers: GC15M026503 GC15P025077 GC15P029901 GC15P030038 GC15P030110 GC15M008072 GC15P030877


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHRNA7 Gene:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that
mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of
homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain
followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane
domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric
channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that
are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes
an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel
across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for
juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An
evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this
gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Feb 2012)

GeneCards Summary for CHRNA7 Gene: 
CHRNA7 (cholinergic receptor, nicotinic, alpha 7 (neuronal)) is a protein-coding gene. Diseases associated with CHRNA7 include 15q13.3 microdeletion, and schizophrenia, and among its related super-pathways are Presynaptic nicotinic acetylcholine receptors and Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and protein homodimerization activity. An important paralog of this gene is CHRNA5.

UniProtKB/Swiss-Prot: ACHA7_HUMAN, P36544
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all
subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by
alpha-bungarotoxin

summary for CHRNA7 Gene:
Alpha7 is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. In
avian tissue alpha7alpha8 heteromers also occur and an association between alpha7 and beta2 subunits has
been suggested in the mammalian brain. The alpha7 nAChR is particularly prominent in the hippocampus, where
it is found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.
Presynaptic alpha7 nAChRs are present on glutamate terminals and facilitate transmitter release in various
brain regions, including the hippocampus, cortex and ventral tegmental area. Nicotine acting at alpha7
nAChRs can enhance hippocampal LTP, and alpha7 nAChRs are associated with attentional processes and working
memory. As a consequence, alpha7 nAChRs are a therapeutic target for treating cognitive impairment, notably
in Alzheimer's disease and schizophrenia, and this has prompted the generation of alpha7 nAChR-selective
ligands. The human gene encoding the nicotinic alpha7 receptor subunit has been localized to chromosome 15
(15q13.3).

Gene Wiki entry for CHRNA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHRNA7 gene promoter:
         SRF   NF-1   SRF (504 AA)   Nkx2-5   STAT5A   NF-E2 p45   FOXL1   C/EBPalpha   AREB6   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRNA7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHRNA7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRNA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q13.3   HGNC cytogenetic band: 15q13.3

CHRNA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRNA7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P032322:  view genomic region     (about GC identifiers)

Start:
32,322,691 bp from pter      End:
32,464,722 bp from pter
Size:
142,032 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACHA7_HUMAN, P36544 (See protein sequence)
Recommended Name: Neuronal acetylcholine receptor subunit alpha-7 precursor  
Size: 502 amino acids; 56449 Da
Subunit: Homopentamer. Interacts with RIC3; which is required for proper folding and assembly
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
membrane; Multi-pass membrane protein
Mass spectrometry: Mass=54157.68; Method=MALDI; Range=23-502; Source=PubMed:11840567;
Secondary accessions: A8K7Q4 B4DFS0 Q15826 Q8IUZ4 Q96RH2 Q99555 Q9BXH0
Alternative splicing: 3 isoforms:  P36544-1   P36544-2   P36544-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHRNA7: NX_P36544

Explore proteomics data for CHRNA7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P36544

  • CHRNA7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHRNA7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000737.1  NP_001177384.1  

    ENSEMBL proteins: 
     ENSP00000407546   ENSP00000303727   ENSP00000399087   ENSP00000405989  
    Reactome Protein details: P36544
    Human Recombinant Protein Products for CHRNA7: 
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    OriGene Protein Over-expression Lysate for CHRNA7
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    Novus Biologicals CHRNA7 Protein
    Novus Biologicals CHRNA7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005892acetylcholine-gated channel complex IDA8906617
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS8145738
    GO:0030054cell junction IEA--

    CHRNA7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CHRN: Ligand-gated ion channels / Acetylcholine receptors, nicotinic
    CHR: Cholinergic receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: α7 
    Nicotinic acetylcholine receptors

    5/6 InterPro protein domains (see all 6):
     IPR027361 Acetylcholine_rcpt_TM
     IPR002394 Nicotinic_acetylcholine_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry P36544

    ProtoNet protein and cluster: P36544

    2 Blocks protein domains:
    IPB002394 Nicotinic acetylcholine receptor signature
    IPB006201 Neurotransmitter-gated ion-channel


    UniProtKB/Swiss-Prot: ACHA7_HUMAN, P36544
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1)
    subfamily. Alpha-7/CHRNA7 sub-subfamily


    CHRNA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACHA7_HUMAN, P36544
    Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all
    subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by
    alpha-bungarotoxin

         Genatlas biochemistry entry for CHRNA7:
    cholinergic receptor,nicotinic,alpha 7 polypeptide (alpha-bungarotoxin binding),brain,partially duplicated

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IPI10681545
    GO:0004889acetylcholine-activated cation-selective channel activity IDA12508119
    GO:0005230extracellular ligand-gated ion channel activity ----
    GO:0015464acetylcholine receptor activity IDA8906617
    GO:0015643toxic substance binding IDA12508119
         
    CHRNA7 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chrna7):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  reproductive system  respiratory system 

    CHRNA7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Chrna7tm1Bay for CHRNA7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHRNA7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHRNA7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHRNA7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHRNA7 

    miRNA
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    hsa-miR-146a* hsa-miR-576-5p hsa-miR-499-5p hsa-miR-370 hsa-miR-2355-3p hsa-miR-4263 hsa-miR-3652 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidCHRNA7 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CHRNA7 (NM_000746)
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHRNA7 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Presynaptic nicotinic acetylcholine receptors
    Acetylcholine Binding And Downstream Events0.86
    Postsynaptic nicotinic acetylcholine receptors0.86
    Activation of Nicotinic Acetylcholine Receptors0.86
    Highly calcium permeable postsynaptic nicotinic acetylcholine receptors0.82
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    3Drug metabolism - cytochrome P450
    Chemical carcinogenesis0.77
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CHRNA7
        Calcium channels

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CHRNA7
        eNOS Signaling
    Intracellular Calcium Signaling

    1 BioSystems Pathway for CHRNA7
        SIDS Susceptibility Pathways

    5/7        Reactome Pathways for CHRNA7 (see all 7)
        Activation of Nicotinic Acetylcholine Receptors
    Transmission across Chemical Synapses
    Postsynaptic nicotinic acetylcholine receptors
    Acetylcholine Binding And Downstream Events
    Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

    1 PharmGKB Pathway for CHRNA7
        Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

    5         Kegg Pathways  (Kegg details for CHRNA7):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Cholinergic synapse
    Nicotine addiction
    Chemical carcinogenesis


    CHRNA7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHRNA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/21 Interacting proteins for CHRNA7 (P365443 ENSP000003037274) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY6O433063, ENSP000003114054I2D: score=2 STRING: ENSP00000311405
    APPP050673, ENSP000002849814I2D: score=2 STRING: ENSP00000284981
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    CHRNA2ENSP000002401324STRING: ENSP00000240132
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA10771023
    GO:0001666response to hypoxia IDA12189247
    GO:0006810transport ----
    GO:0006811ion transport NAS8906617
    GO:0006816calcium ion transport IMP10771023

    CHRNA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHRNA7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CHRNA7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NS 1738Positive allosteric modulator of alpha7 nAChR; active in vivo[501684-93-1]
    alpha-Bungarotoxinalpha7 subtype-selective nAChR antagonist[11032-79-4]
    Methyllycaconitine citratealpha7 neuronal nicotinic receptor antagonist[21019-30-7]
    PNU 282987Selective alpha7 nAChR agonist[123464-89-1]
    PNU 120596Positive allosteric modulator of alpha7 nAChR; active in vivo[501925-31-1]

    10/20 DrugBank Compounds for CHRNA7 (see all 20)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Galantamine(-)-Galanthamine (see all 3)357-70-0targetallosteric modulator12137632 11129124 12481195 20480924 12177686 10971048
    NicotineL-Nicotine (see all 2)54-11-5targetagonist19560048 20081230 16754836 20400469 11006350 17360707
    Amobarbital-- 57-43-2targetantagonist11264449 16248797 10487207
    Aprobarbital-- 77-02-1targetantagonist11264449 16248797 10487207
    Barbital-- 57-44-3targetantagonist11264449 16248797 10487207
    Barbituric acid derivative-- --targetantagonist11264449 16248797 10487207
    ButabarbitalButabarbital Sodium (see all 8)125-40-6targetantagonist11264449 16248797 10487207
    ButalbitalAllylbarbital (see all 2)77-26-9targetantagonist11264449 16248797 10487207
    Butethal5-Butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (see all 10)77-28-1targetantagonist11264449 16248797 10487207
    HeptabarbitalHeptabarb (see all 9)509-86-4targetantagonist11264449 16248797 10487207

    10/21 IUPHAR Ligands for CHRNA7 (α7) (see all 21)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]epibatidine
    NoneNone12.22--
    [3H]A-585539
    NoneNone10.1517959745
    [3H]AZ11637326
    NoneNone9.6420674564
    [3H]α-bungarotoxin
    NoneNone9.15 - 8.3--
    [125I]α-bungarotoxin
    NoneNone9.15 - 8.3--
    mecamylamine
    Channel blockerNone4.81--
    LY2087101
    Allosteric regulatorPositive4.8116738207
    PHA-709829
    AgonistFull agonist4.8118490160
    α-bungarotoxin
    AntagonistAntagonist4.81--
    4BP-TQS
    AgonistFull agonist4.8121436053

    10/52 Novoseek inferred chemical compound relationships for CHRNA7 gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methyllycaconitine 94.6 25 20377277 (2), 15469877 (1), 10619630 (1), 10987839 (1) (see all 17)
    alpha-bungarotoxin 92.9 21 12614199 (2), 11207427 (2), 10987839 (1), 17254563 (1) (see all 18)
    3 (2,4 dimethoxybenzylidene)anabaseine 91.5 4 19956085 (1), 16754836 (1)
    dmxba 86.9 1 10942043 (1)
    nicotine 84.6 60 16846598 (6), 17254563 (3), 10942036 (2), 10686080 (1) (see all 44)
    5-hydroxyindole 83.3 2 12243767 (1)
    dihydro-beta-erythroidine 83 8 15469877 (1), 19728991 (1), 10082212 (1), 11906789 (1) (see all 6)
    epibatidine 77.5 3 15590768 (1), 19954975 (1), 15588622 (1)
    acetylcholine 73.2 39 16506783 (3), 17522313 (2), 14581202 (1), 15357617 (1) (see all 32)
    mecamylamine 72.5 5 10619630 (1), 17254563 (1), 11600102 (1), 17016705 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about CHRNA7 / ACHA7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHRNA7 gene (2 alternative transcripts): 
    NM_000746.5  NM_001190455.2  

    Unigene Clusters for CHRNA7:

    Cholinergic receptor, nicotinic, alpha 7 (neuronal)
    Hs.511772  [show with all ESTs], Hs.713151
    Unigene Representative Sequences: NM_001190455, BE141315
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454250(uc010bad.2 uc010bab.2 uc010bac.2 uc010bae.2 uc010bag.1 uc010bah.1 uc010bai.1)
    ENST00000306901(uc001zft.3 uc021sic.1 uc010baf.3 uc010bak.3)
    ENST00000437966 ENST00000455693(uc010baj.1)

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    Additional mRNA sequence: EF405821.1 

    5 DOTS entries:

    DT.100778392  DT.100025592  DT.97837952  DT.100778391  DT.100778393 

    24/71 AceView cDNA sequences (see all 71):

    CR620753 BU680930 AA639641 BF507825 NM_000746 BM451308 BX422848 CR605947 
    CR594008 BX090309 AA301331 AI791902 BX282644 BI963064 BU149265 BC037571 
    AI208142 AA897701 CR608436 AU253238 L25827 BQ720423 Y08420 BG925223 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHRNA7 expression in normal human tissues (normalized intensities)      CHRNA7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHRNA7 Expression
    About this image


    CHRNA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             autonomic/sympathetic/ganglion   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Rhombencephalon
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See CHRNA7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHRNA7

    SOURCE GeneReport for Unigene clusters: Hs.511772 Hs.713151
        SABiosciences Expression via Pathway-Focused PCR Array including CHRNA7: 
              Neurotransmitter Receptors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHRNA7 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrna71 , 5 cholinergic receptor, nicotinic, alpha polypeptide more1, 5 88.06(n)1
    93.96(a)1
      7 (34.47 cM)5
    114411  NM_007390.31  NP_031416.31 
     630986925 
    chicken
    (Gallus gallus)
    Aves CHRNA71 cholinergic receptor, nicotinic, alpha 7 (neuronal) 77.64(n)
    90.91(a)
      374001  NM_204181.2  NP_989512.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    81(a)
    67(a)
    (see all 3)
    1 ↔ many
    possible ortholog
    (see all 3)
    GL343486.1(221428-260641)
    GL343339.1(474411-672913)
    zebrafish
    (Danio rerio)
    Actinopterygii chrna72 cholinergic receptor, nicotinic, alpha polypeptide more 76.56(n)   394199  AY247962.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nAcRalpha-18C3
    nAcRalpha-34E1
    nicotinic acetylcholine-activated
    cation-selective more3
    nicotinic Acetylcholine Receptor alpha 34E1
    60(a)
    (best of 6)3
    54.86(n)1
    50.83(a)1
      348261  NM_205985.21  NP_995707.21 
    worm
    (Caenorhabditis elegans)
    Secernentea acr-191 , 3 nicotinic acetylcholine receptor3
    Protein ACR-191
    49(a)
    (best of 21)3
    51.94(n)1
    50(a)1
      I(9039491-9044719)3
    1916051  NM_060028.41  NP_492429.21 


    ENSEMBL Gene Tree for CHRNA7 (if available)
    TreeFam Gene Tree for CHRNA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHRNA7 gene
    CHRNA52  CHRNA22  CHRNA12  CHRNA62  CHRNE2  CHRNB42  CHRNA42  CHRNA102  
    CHRNA92  CHRNB22  CHRNG2  CHRNA32  CHRFAM7A2  CHRNB32  CHRNB12  CHRND2  
    17 SIMAP similar genes for CHRNA7 using alignment to 3 protein entries:     ACHA7_HUMAN (see all proteins):
    CHRFAM7A    CHRNA7-2    CHRNA2    CHRNA4    CHRNB4    CHRNA9
    CHRNA1    CHRNA3    CHRNA6    CHRNB2    CHRNA10    CHRNB1
    CHRNB3    CHRND    CHRNA5    CHRNG    CHRNE

    CHRNA7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3062 SNPs in CHRNA7 are shown (see all 3062)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs791565891,2
    C,F--12360129(+) ACCTAC/ACTATG 5 -- us2k11Minor allele frequency- A:0.02NA 120
    rs727135271,2
    C,F--12360153(+) TGAAGT/CTTATT 5 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1161782141,2
    F--12360258(+) ATTTAC/TGAATT 5 -- us2k11Minor allele frequency- T:0.03WA 118
    rs30874541,2
    C,F,A,H--12360383(-) TTATTA/C/G/
            
    ATTTT
    5 -- us2k1 tfbs312NA CSA WA EA 551
    rs1166726821,2
    F--12360421(+) CTTCTA/GGAAGG 5 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1920901821,2
    --12360607(+) CCCCTA/GTAGAT 6 -- us2k10--------
    rs1834906511,2
    --12360627(+) ATCAAG/TTGCCT 6 -- us2k10--------
    rs1422056531,2
    --12360629(+) CAAGTA/GCCTGC 6 -- us2k10--------
    rs1458518231,2
    C--12360700(+) GCACGC/TCTGTC 6 -- us2k10--------
    rs64941651,2
    C,F,A,H--12360702(+) ACGCCT/GGTCTG 6 -- us2k121Minor allele frequency- G:0.09NS EA NA WA 2588

    HapMap Linkage Disequilibrium report for CHRNA7 (32322691 - 32464722 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/46 variations for CHRNA7 (see all 46):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749539CNV Deletion23290073
    esv2749540CNV Deletion23290073
    esv2668191CNV Deletion23128226
    esv2749542CNV Deletion23290073
    dgv11e196CNV Duplication17116639
    dgv2318n71CNV Loss21882294
    dgv2317n71CNV Loss21882294
    nsv819078CNV Loss19587683
    dgv2322n71CNV Loss21882294
    nsv469726CNV Loss16826518


    Human Gene Mutation Database (HGMD): CHRNA7
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 118511    OMIM disorders: --

    20/42 diseases for CHRNA7 (see all 42):    About MalaCards
    15q13.3 microdeletion    schizophrenia    juvenile myoclonic epilepsy    rasmussen encephalitis
    nicotine dependence    neuronitis    ectopic pregnancy    attention deficit hyperactivity disorder
    idiopathic generalized epilepsy    alzheimer's disease    bipolar disorder    schizoaffective disorder
    brain disease    pemphigus    psoriatic arthritis    major depressive disorder
    down syndrome    pheochromocytoma    encephalitis    pancreatic ductal adenocarcinoma

    5 diseases from the University of Copenhagen DISEASES database for CHRNA7:
    Schizophrenia     Autistic disorder     Nicotine dependence     Intermittent explosive disorder
    Schizoaffective disorder

    CHRNA7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/27 Novoseek inferred disease relationships for CHRNA7 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 74.9 132 19181484 (6), 16889592 (5), 16134405 (4), 17113175 (4) (see all 60)
    alzheimers disease 67.8 47 11958863 (2), 17493709 (2), 18078695 (2), 19433665 (2) (see all 38)
    cognitive deficit 59.9 10 17094961 (2), 17898229 (1), 17504249 (1), 17601496 (1) (see all 9)
    senile plaques 54.2 4 11958863 (1), 19587288 (1), 15698636 (1), 10681545 (1)
    cognitive dysfunction 50.4 4 19853005 (1), 17349863 (1), 17470817 (1)
    neurodegeneration 39.6 4 18180036 (2), 16842101 (1), 15228589 (1)
    neurodegenerative diseases 27 2 19287501 (1)
    brain diseases 23.2 4 11958863 (1), 19726654 (1), 10681545 (1), 15858066 (1)
    cognitive disorder 22 1 20043678 (1)
    psychotic 19.1 1 16889592 (1)

    Genetic Association Database (GAD): CHRNA7
    Human Genome Epidemiology (HuGE) Navigator: CHRNA7 (56 documents)

    Export disorders for CHRNA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHRNA7 gene, integrated from 9 sources (see all 475):
    (articles sorted by number of sources associating them with CHRNA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localization of the human alpha 7- nicotinic receptor subunit gene (CHRNA7). (PubMed id 8188270)1, 2, 3 Chini B....Heinemann S.F. (1994)
    2. Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. (PubMed id 19181484)1, 4, 9 Stephens S.H....Leonard S. (2009)
    3. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. (PubMed id 12470124)1, 4, 9 Leonard S....Freedman R. (2002)
    4. Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease. (PubMed id 18057084)1, 4, 9 Carson R....Ritchie C.W. (2008)
    5. A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PubMed id 11829490)1, 2, 9 Riley B.... Makoff A. (2002)
    6. Evidence for linkage disequilibrium between the alpha 7-nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families. (PubMed id 11803513)1, 4, 9 Xu J....Pato C.N. (2001)
    7. [The transmission disequilibrium analysis between neuronal nicotinic acetylcholine receptor alpha 7 subunit gene polymorphisms and schizophrenia] (PubMed id 18393235)1, 4, 9 Peng Z.Z....Jiang T.Y. (2008)
    8. Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia. (PubMed id 17113175)1, 4, 9 Iwata Y....Collier D. (2007)
    9. APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease. (PubMed id 18078695)1, 4, 9 Barabash A....Cabranes J.A. (2007)
    10. Population-based and family-based association studies of an (AC)n dinucleotide repeat in alpha-7 nicotinic receptor subunit gene and schizophrenia. (PubMed id 16563701)1, 4, 9 Fan J.B....He L. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1139 HGNC: 1960 AceView: CHRNA7 Ensembl:ENSG00000175344 euGenes: HUgn1139
    ECgene: CHRNA7 Kegg: 1139 H-InvDB: CHRNA7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHRNA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHRNA7 gene:
    Search GeneIP for patents involving CHRNA7

    Licensable Technologies for CHRNA7 gene:
    Weizmann Institute:Diagnosis and Follow-up of Schizophrenia
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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