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Aliases for CHRNA7 Gene

Aliases for CHRNA7 Gene

  • Cholinergic Receptor Nicotinic Alpha 7 Subunit 2 3 5
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 7 2 3
  • Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal) 2 3
  • Cholinergic Receptor, Nicotinic Alpha 7 2 3
  • NACHRA7 3 4
  • Neuronal Acetylcholine Receptor Protein, Alpha-7 Chain 3
  • Acetylcholine Receptor, Nicotinic, Alpha 7 (Neuronal) 2
  • Alpha 7 Neuronal Nicotinic Acetylcholine Receptor 3
  • Neuronal Acetylcholine Receptor Subunit Alpha-7 3
  • Alpha-7 Nicotinic Cholinergic Receptor Subunit 3
  • A7 Nicotinic Acetylcholine Receptor 3
  • CHRNA7-2 3

External Ids for CHRNA7 Gene

Previous GeneCards Identifiers for CHRNA7 Gene

  • GC15M026503
  • GC15P025077
  • GC15P029901
  • GC15P030038
  • GC15P030110
  • GC15P032322
  • GC15M008072
  • GC15P030877
  • GC15P032030

Summaries for CHRNA7 Gene

Entrez Gene Summary for CHRNA7 Gene

  • The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

GeneCards Summary for CHRNA7 Gene

CHRNA7 (Cholinergic Receptor Nicotinic Alpha 7 Subunit) is a Protein Coding gene. Diseases associated with CHRNA7 include Chrna7-Related Disorders and Chromosome 15Q13.3 Microdeletion Syndrome. Among its related pathways are Drug metabolism - cytochrome P450 and Transmission across Chemical Synapses. GO annotations related to this gene include protein homodimerization activity and beta-amyloid binding. An important paralog of this gene is CHRFAM7A.

UniProtKB/Swiss-Prot for CHRNA7 Gene

  • After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Tocris Summary for CHRNA7 Gene

  • Alpha 7 (alpha7) is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. The alpha7 nAChR is prominent in the hippocampus, found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.

Gene Wiki entry for CHRNA7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA7 Gene

Genomics for CHRNA7 Gene

Regulatory Elements for CHRNA7 Gene

Enhancers for CHRNA7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F031433 1.6 FANTOM5 Ensembl ENCODE 14.6 -484.6 -484636 11.6 HDGF PKNOX1 ATF1 WRNIP1 SIN3A ARID4B ZNF143 FOS SP5 JUNB ENSG00000270055 CHRNA7 ENSG00000269930 MTMR10 ENSG00000261628 KLF13 UBE2CP4 LOC400347
GH15F032091 0.9 FANTOM5 ENCODE 12.7 +168.5 168471 1.0 CHRNA7 LOC105370940 PIR39753
GH15F031214 0.9 ENCODE 12.7 -707.6 -707624 3.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GLIS2 ZNF143 ENSG00000270055 CHRNA7 LOC102725022 PIR62095
GH15F031527 0.2 ENCODE 11.2 -396.0 -395956 0.1 CHRNA7 LOC105370753 PIR44636
GH15F032028 0.9 ENCODE 10.5 +105.7 105655 0.2 CTCF ZNF341 PRDM10 PRDM1 RAD21 CHRNA7 LOC105370940 ENSG00000206849
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CHRNA7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHRNA7 Gene

Chromosome:
15
Start:
31,923,438 bp from pter
End:
32,173,018 bp from pter
Size:
249,581 bases
Orientation:
Plus strand

Genomic View for CHRNA7 Gene

Genes around CHRNA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRNA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRNA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA7 Gene

Proteins for CHRNA7 Gene

  • Protein details for CHRNA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36544-ACHA7_HUMAN
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-7
    Protein Accession:
    P36544
    Secondary Accessions:
    • A8K7Q4
    • B4DFS0
    • Q15826
    • Q8IUZ4
    • Q96RH2
    • Q99555
    • Q9BXH0

    Protein attributes for CHRNA7 Gene

    Size:
    502 amino acids
    Molecular mass:
    56449 Da
    Quaternary structure:
    • Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.
    SequenceCaution:
    • Sequence=AAH37571.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHRNA7 Gene

    Alternative splice isoforms for CHRNA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHRNA7 Gene

Post-translational modifications for CHRNA7 Gene

  • Glycosylation at Asn 46, Asn 90, and Asn 133
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for CHRNA7

No data available for DME Specific Peptides for CHRNA7 Gene

Domains & Families for CHRNA7 Gene

Gene Families for CHRNA7 Gene

Graphical View of Domain Structure for InterPro Entry

P36544

UniProtKB/Swiss-Prot:

ACHA7_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
genes like me logo Genes that share domains with CHRNA7: view

Function for CHRNA7 Gene

Molecular function for CHRNA7 Gene

GENATLAS Biochemistry:
cholinergic receptor,nicotinic,alpha 7 polypeptide (alpha-bungarotoxin binding),brain,partially duplicated
UniProtKB/Swiss-Prot Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Gene Ontology (GO) - Molecular Function for CHRNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IPI 10681545
GO:0004889 acetylcholine-activated cation-selective channel activity IEA --
GO:0005216 ion channel activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0015276 ligand-gated ion channel activity TAS --
genes like me logo Genes that share ontologies with CHRNA7: view
genes like me logo Genes that share phenotypes with CHRNA7: view

Human Phenotype Ontology for CHRNA7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CHRNA7 Gene

MGI Knock Outs for CHRNA7:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHRNA7

miRNA for CHRNA7 Gene

miRTarBase miRNAs that target CHRNA7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CHRNA7 Gene

Localization for CHRNA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA7 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRNA7 Gene COMPARTMENTS Subcellular localization image for CHRNA7 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CHRNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005892 acetylcholine-gated channel complex IDA 8906617
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 8145738
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CHRNA7: view

Pathways & Interactions for CHRNA7 Gene

genes like me logo Genes that share pathways with CHRNA7: view

SIGNOR curated interactions for CHRNA7 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CHRNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 10771023
GO:0001666 response to hypoxia IDA 12189247
GO:0006810 transport IEA --
GO:0006811 ion transport IEA,NAS 8906617
GO:0006816 calcium ion transport IMP 10771023
genes like me logo Genes that share ontologies with CHRNA7: view

Drugs & Compounds for CHRNA7 Gene

(145) Drugs for CHRNA7 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Galantamine Approved Pharma Target, allosteric modulator 105
Nicotine Approved Pharma Antagonist, antagonist, Target, agonist 1050
Ethanol Approved Pharma Target 2043
Mecamylamine Approved Pharma Channel blocker, antagonist 25
Ivermectin Approved, Vet_approved Pharma activator NAChR/purinergic P2X4 receptor modulator 57

(24) Additional Compounds for CHRNA7 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-Bungarotoxin
Antagonist 11032-79-4
[<sup>125</sup>I]alpha-bungarotoxin
[<sup>3</sup>H]alpha-bungarotoxin
alpha-conotoxin ArIB
Antagonist
alpha-conotoxin ImI
Antagonist

(5) Tocris Compounds for CHRNA7 Gene

Compound Action Cas Number
alpha-Bungarotoxin alpha7 subtype-selective nAChR antagonist 11032-79-4
Methyllycaconitine citrate alpha7 neuronal nicotinic receptor antagonist 112825-05-5
NS 1738 Positive allosteric modulator of alpha7 nAChR; active in vivo 501684-93-1
PHA 543613 hydrochloride Potent and selective alpha7 nAChR agonist 478149-53-0
PNU 120596 Positive allosteric modulator of alpha7 nAChR; active in vivo 501925-31-1

(61) ApexBio Compounds for CHRNA7 Gene

Compound Action Cas Number
(-)-Lobeline hydrochloride 134-63-4
(+)-Anabasine hydrochloride 53912-89-3
(+)-Tubocurarine chloride 57-94-3
(±)-Anatoxin A fumarate 1219922-30-1
(±)-Epibatidine dopamine receptor antagonist 148152-66-3
1-Acetyl-4-methylpiperazine hydrochloride 144205-68-5
3-Bromocytisine 207390-14-5
4-Acetyl-1,1-dimethylpiperazinium iodide 75667-84-4
5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative 213766-21-3
A 582941 Selective α7 nAChR partial agonist 848591-90-2
A 844606 α7 nAChR partial agonist 861119-08-6
Adiphenine HCl 50-42-0
AR-R 17779 hydrochloride Selective agonist of α7 nAChRs 178419-42-6
Benzoquinonium dibromide inhibitor of AChR and ganglion 311-09-1
bPiDDB 525596-66-1
Carbamoylcholine chloride 51-83-2
Catestatin 142211-96-9
Catharanthine 2468-21-5
CCMI 917837-54-8
Chlorisondamine diiodide 96750-66-2
COG 133 ApoE mimetic peptide 514200-66-9
Desformylflustrabromine hydrochloride 951322-11-5
Dihydro-β-erythroidine hydrobromide antagonist of nAChRs 29734-68-7
DMAB-anabaseine dihydrochloride 154149-38-9
EVP-6124 NAChRs agonist 550999-75-2
EVP-6124 hydrochloride Alpha7 nAChR agonist 550999-74-1
Galanthamine Acetylcholinesterase inhibitor 357-70-0
GTS 21 dihydrochloride nAChRs agonist, novel 156223-05-1
Ivermectin NAChR/purinergic P2X4 receptor modulator 70288-86-7
Ivermectin B1a-d2
LX-1031 TPH inhibitor 945976-76-1
LY 2087101 913186-74-0
Mecamylamine hydrochloride 826-39-1
Methyllycaconitine citrate 112825-05-5
MG 624 77257-42-2
NS 1738 501684-93-1
PHA 543613 hydrochloride 478149-53-0
PHA 568487 527680-57-5
PNU 282987 123464-89-1
PNU-120596 α7 nAChR modulator,positive allosteric 501925-31-1
Rivastigmine Cholinesterase inhibitor 123441-03-2
RJR 2429 dihydrochloride 1021418-53-0
RJR-2403 Nicotinic receptor agonist,highly selective 15585-43-0
RJR-2403 hemioxalate Neuronal nicotinic receptor agonist
RJR-2403 oxalate Nicotinic receptor agonist 220662-95-3
RuBi-Nicotine 1256362-30-7
S 24795 304679-75-2
Sazetidine A dihydrochloride 1197329-42-2
SEN 12333 874450-44-9
SIB 1553A hydrochloride 191611-89-9
SR 16584 1150153-86-8
TC 1698 dihydrochloride 787587-06-8
TC 2559 difumarate 212332-35-9
TMPH hydrochloride 849461-91-2
TQS 353483-92-8
UB 165 fumarate 200432-86-6
vinblastine 865-21-4
α-Bungarotoxin 11032-79-4
α-Conotoxin AuIB 216299-21-7
α-Conotoxin EI 170663-33-9
α-Conotoxin PnIA 705300-84-1
genes like me logo Genes that share compounds with CHRNA7: view

Drug Products

Transcripts for CHRNA7 Gene

Unigene Clusters for CHRNA7 Gene

Cholinergic receptor, nicotinic, alpha 7 (neuronal):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA7 Gene

No ASD Table

Relevant External Links for CHRNA7 Gene

GeneLoc Exon Structure for
CHRNA7
ECgene alternative splicing isoforms for
CHRNA7

Expression for CHRNA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHRNA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CHRNA7 Gene:

CHRNA7

SOURCE GeneReport for Unigene cluster for CHRNA7 Gene:

Hs.511772
genes like me logo Genes that share expression patterns with CHRNA7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CHRNA7 Gene

Orthologs for CHRNA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRNA7 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia CHRNA7 34 35
  • 91.18 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Chrna7 34 16 35
  • 88.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CHRNA7 34
  • 87.93 (n)
rat
(Rattus norvegicus)
Mammalia Chrna7 34
  • 87.59 (n)
chicken
(Gallus gallus)
Aves CHRNA7 34 35
  • 77.64 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493611 34
  • 73.6 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01088685.1 35
  • 85 (a)
ManyToMany
CABZ01069081.1 35
  • 74 (a)
ManyToMany
chrna7 34 35
  • 71.53 (n)
si:ch211-39a7.1 35
  • 58 (a)
ManyToMany
si:ch211-256e16.6 35
  • 21 (a)
ManyToMany
BX255960.1 35
  • 20 (a)
ManyToMany
CABZ01073083.1 35
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta nAcRalpha-18C 36
  • 60 (a)
nAcRalpha-34E 36 34 35
  • 55.28 (n)
nAcRalpha-30D 36 35
  • 50 (a)
nAcRalpha-7E 36
  • 46 (a)
nAcRalpha-96Aa 36
  • 46 (a)
gfA 35
  • 43 (a)
ManyToMany
nAcRalpha-96Ab 36
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008588 34
  • 55.21 (n)
worm
(Caenorhabditis elegans)
Secernentea acr-16 36 34 35
  • 49.21 (n)
acr-19 36 35
  • 49 (a)
acr-10 36 35
  • 43 (a)
acr-11 36 35
  • 40 (a)
acr-9 36 35
  • 38 (a)
acr-7 36 35
  • 37 (a)
F18G5.4 36
  • 36 (a)
Y73F8A.30 36
  • 36 (a)
eat-2 35
  • 36 (a)
ManyToMany
acr-12 36
  • 33 (a)
acr-14 36 35
  • 33 (a)
acr-15 36 35
  • 33 (a)
unc-29 36
  • 33 (a)
acr-21 35
  • 33 (a)
ManyToMany
acr-25 35
  • 33 (a)
ManyToMany
acr-17 36 35
  • 32 (a)
acr-5 36 35
  • 31 (a)
acr-18 36 35
  • 30 (a)
acr-22 36
  • 30 (a)
ZK973.5 36
  • 30 (a)
acr-8 36
  • 29 (a)
deg-3 36 35
  • 29 (a)
C04C3.2 36
  • 28 (a)
Y57G11C.2 36
  • 28 (a)
lgc-12 35
  • 25 (a)
ManyToMany
lgc-4 35
  • 25 (a)
ManyToMany
des-2 35
  • 24 (a)
ManyToMany
lgc-11 35
  • 24 (a)
ManyToMany
acr-20 35
  • 23 (a)
ManyToMany
acr-23 35
  • 23 (a)
ManyToMany
acr-24 35
  • 23 (a)
ManyToMany
lgc-7 35
  • 23 (a)
ManyToMany
lgc-8 35
  • 23 (a)
ManyToMany
lgc-9 35
  • 23 (a)
ManyToMany
pbo-6 35
  • 22 (a)
ManyToMany
lgc-10 35
  • 21 (a)
ManyToMany
lgc-6 35
  • 21 (a)
ManyToMany
pbo-5 35
  • 21 (a)
ManyToMany
lgc-16 35
  • 19 (a)
ManyToMany
lgc-17 35
  • 19 (a)
ManyToMany
lgc-18 35
  • 19 (a)
ManyToMany
lgc-13 35
  • 18 (a)
ManyToMany
lgc-14 35
  • 18 (a)
ManyToMany
lgc-30 35
  • 18 (a)
ManyToMany
lgc-15 35
  • 17 (a)
ManyToMany
lgc-19 35
  • 17 (a)
ManyToMany
lgc-29 35
  • 17 (a)
ManyToMany
lgc-31 35
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for CHRNA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA7 Gene

ENSEMBL:
Gene Tree for CHRNA7 (if available)
TreeFam:
Gene Tree for CHRNA7 (if available)

Paralogs for CHRNA7 Gene

Paralogs for CHRNA7 Gene

(17) SIMAP similar genes for CHRNA7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHRNA7: view

Variants for CHRNA7 Gene

Sequence variations from dbSNP and Humsavar for CHRNA7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs749361514 Uncertain significance 32,030,931(+) GCTTT(A/G)CAAGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1039394 -- 32,115,528(-) AAGCA(C/G)TAGGG intron-variant
rs1039395 -- 32,064,493(-) acaca(C/T)acaca intron-variant
rs1042722 -- 32,158,503(+) AGGAC(A/G)CTCTA intron-variant, nc-transcript-variant, reference, synonymous-codon
rs1042724 -- 32,168,218(+) CACGG(C/T)GGGCA intron-variant, nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CHRNA7 Gene

Variant ID Type Subtype PubMed ID
dgv109e55 CNV gain 17911159
dgv11e196 CNV duplication 17116639
dgv2535n100 CNV gain 25217958
dgv2536n100 CNV gain 25217958
dgv2537n100 CNV gain 25217958
dgv2538n100 CNV loss 25217958
dgv2539n100 CNV loss 25217958
dgv2540n100 CNV loss 25217958
dgv2541n100 CNV loss 25217958
dgv2542n100 CNV loss 25217958
dgv2543n100 CNV gain 25217958
dgv2544n100 CNV gain+loss 25217958
dgv306n27 CNV gain 19166990
dgv308n27 CNV gain 19166990
dgv4440n54 CNV gain 21841781
dgv4442n54 CNV gain 21841781
dgv4444n54 CNV gain 21841781
dgv4446n54 CNV loss 21841781
dgv726e212 CNV gain 25503493
esv25982 CNV gain+loss 19812545
esv2668191 CNV deletion 23128226
esv2760023 CNV gain+loss 17122850
esv2760365 CNV gain+loss 21179565
esv2760376 CNV gain+loss 21179565
esv2761877 CNV gain+loss 21179565
esv33337 CNV gain+loss 17666407
esv3636065 CNV gain 21293372
esv3636067 CNV gain 21293372
esv3636068 CNV gain 21293372
esv3636071 CNV loss 21293372
esv3892651 CNV loss 25118596
esv3892652 CNV loss 25118596
esv3892653 CNV gain 25118596
esv3892655 CNV gain 25118596
esv3892656 CNV loss 25118596
nsv1035202 CNV gain+loss 25217958
nsv1050172 CNV gain 25217958
nsv1126391 CNV deletion 24896259
nsv1144730 CNV deletion 24896259
nsv428302 CNV gain+loss 18775914
nsv469726 CNV loss 16826518
nsv469870 CNV gain 16826518
nsv471234 CNV gain 18288195
nsv471680 CNV gain+loss 15918152
nsv471681 CNV gain+loss 15918152
nsv517740 CNV gain+loss 19592680
nsv568825 CNV gain 21841781
nsv568862 CNV gain 21841781
nsv568863 CNV loss 21841781
nsv568864 CNV loss 21841781
nsv817680 CNV gain 17921354
nsv819078 CNV loss 19587683
nsv821680 CNV gain 15273396
nsv832956 CNV gain 17160897
nsv9237 CNV gain+loss 18304495
nsv9238 CNV gain+loss 18304495

Variation tolerance for CHRNA7 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRNA7 Gene

Human Gene Mutation Database (HGMD)
CHRNA7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHRNA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA7 Gene

Disorders for CHRNA7 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CHRNA7 Gene - From: GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chrna7-related disorders
  • acetylcholine receptor, neuronal nicotinic receptor, neuronal nicotinic, alpha-7 subunit
chromosome 15q13.3 microdeletion syndrome
  • chromosome 15q13.3 deletion syndrome
schizophrenia
  • schizophrenia 12
autosomal dominant nocturnal frontal lobe epilepsy
  • epilepsy, nocturnal frontal lobe, 1
rasmussen encephalitis
  • re
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CHRNA7

Genetic Association Database (GAD)
CHRNA7
Human Genome Epidemiology (HuGE) Navigator
CHRNA7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRNA7
genes like me logo Genes that share disorders with CHRNA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHRNA7 Gene

Publications for CHRNA7 Gene

  1. Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. (PMID: 19181484) Stephens S.H. … Leonard S. (Schizophr. Res. 2009) 3 22 46 64
  2. APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease. (PMID: 18078695) Barabash A. … Cabranes J.A. (Neurobiol. Aging 2009) 3 22 46 64
  3. Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease. (PMID: 18057084) Carson R. … Ritchie C.W. (J. Med. Genet. 2008) 3 22 46 64
  4. Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease. (PMID: 18696274) Carson R. … Passmore A.P. (Neuromolecular Med. 2008) 3 22 46 64
  5. [The transmission disequilibrium analysis between neuronal nicotinic acetylcholine receptor alpha 7 subunit gene polymorphisms and schizophrenia]. (PMID: 18393235) Peng Z.Z. … Jiang T.Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008) 3 22 46 64

Products for CHRNA7 Gene

Sources for CHRNA7 Gene

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