Aliases for CHRNA7 Gene
- Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal) 2 3
- Cholinergic Receptor, Nicotinic, Alpha Polypeptide 7 2 3
- NACHRA7 3 4
- Neuronal Acetylcholine Receptor Protein, Alpha-7 Chain 3
- Alpha 7 Neuronal Nicotinic Acetylcholine Receptor 3
- Neuronal Acetylcholine Receptor Subunit Alpha-7 3
- Alpha-7 Nicotinic Cholinergic Receptor Subunit 3
External Ids for CHRNA7 Gene
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
GeneCards Summary for CHRNA7 Gene
CHRNA7 (Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal)) is a Protein Coding gene. Diseases associated with CHRNA7 include 15q13.3 microdeletion and schizophrenia. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein homodimerization activity and acetylcholine-activated cation-selective channel activity. An important paralog of this gene is HTR3A.
UniProtKB/Swiss-Prot for CHRNA7 Gene
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin
Alpha7 is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. In avian tissue alpha7alpha8 heteromers also occur and an association between alpha7 and beta2 subunits has been suggested in the mammalian brain. The alpha7 nAChR is particularly prominent in the hippocampus, where it is found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones. Presynaptic alpha7 nAChRs are present on glutamate terminals and facilitate transmitter release in various brain regions, including the hippocampus, cortex and ventral tegmental area. Nicotine acting at alpha7 nAChRs can enhance hippocampal LTP, and alpha7 nAChRs are associated with attentional processes and working memory. As a consequence, alpha7 nAChRs are a therapeutic target for treating cognitive impairment, notably in Alzheimers disease and schizophrenia, and this has prompted the generation of alpha7 nAChR-selective ligands. The human gene encoding the nicotinic alpha7 receptor subunit has been localized to chromosome 15 (15q13.3).