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Aliases for CHRNA7 Gene

Aliases for CHRNA7 Gene

  • Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal) 2 3
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 7 2 3
  • NACHRA7 3 4
  • Neuronal Acetylcholine Receptor Protein, Alpha-7 Chain 3
  • Alpha 7 Neuronal Nicotinic Acetylcholine Receptor 3
  • Alpha-7 Nicotinic Cholinergic Receptor Subunit 3
  • A7 Nicotinic Acetylcholine Receptor 3
  • Acetylcholine Receptor 2
  • Alpha 7 (Neuronal) 2
  • Nicotinic 2
  • CHRNA7-2 3

External Ids for CHRNA7 Gene

Previous GeneCards Identifiers for CHRNA7 Gene

  • GC15M026503
  • GC15P025077
  • GC15P029901
  • GC15P030038
  • GC15P030110
  • GC15P032322
  • GC15M008072
  • GC15P030877

Summaries for CHRNA7 Gene

Entrez Gene Summary for CHRNA7 Gene

  • The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

GeneCards Summary for CHRNA7 Gene

CHRNA7 (Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal)) is a Protein Coding gene. Diseases associated with CHRNA7 include chrna7-related disorders and 15q13.3 microdeletion. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein homodimerization activity and beta-amyloid binding. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for CHRNA7 Gene

  • After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin

Tocris Summary for CHRNA7 Gene

  • Alpha 7 (alpha7) is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. The alpha7 nAChR is prominent in the hippocampus, found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.

Gene Wiki entry for CHRNA7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA7 Gene

Genomics for CHRNA7 Gene

Regulatory Elements for CHRNA7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHRNA7 Gene

32,030,483 bp from pter
32,172,521 bp from pter
142,039 bases
Plus strand

Genomic View for CHRNA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRNA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA7 Gene

Proteins for CHRNA7 Gene

  • Protein details for CHRNA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-7
    Protein Accession:
    Secondary Accessions:
    • A8K7Q4
    • B4DFS0
    • Q15826
    • Q8IUZ4
    • Q96RH2
    • Q99555
    • Q9BXH0

    Protein attributes for CHRNA7 Gene

    502 amino acids
    Molecular mass:
    56449 Da
    Quaternary structure:
    • Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.

    Three dimensional structures from OCA and Proteopedia for CHRNA7 Gene

    Alternative splice isoforms for CHRNA7 Gene


neXtProt entry for CHRNA7 Gene

Proteomics data for CHRNA7 Gene at MOPED

Post-translational modifications for CHRNA7 Gene

  • Glycosylation at Asn 46, Asn 90, and Asn 133
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNA7 Gene

Antibody Products

No data available for DME Specific Peptides for CHRNA7 Gene

Domains & Families for CHRNA7 Gene

Gene Families for CHRNA7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
genes like me logo Genes that share domains with CHRNA7: view

Function for CHRNA7 Gene

Molecular function for CHRNA7 Gene

GENATLAS Biochemistry:
cholinergic receptor,nicotinic,alpha 7 polypeptide (alpha-bungarotoxin binding),brain,partially duplicated
UniProtKB/Swiss-Prot Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin

Gene Ontology (GO) - Molecular Function for CHRNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IPI 10681545
GO:0004889 acetylcholine-activated cation-selective channel activity IDA 8145738
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0005515 protein binding --
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with CHRNA7: view
genes like me logo Genes that share phenotypes with CHRNA7: view

Animal Models for CHRNA7 Gene

MGI Knock Outs for CHRNA7:

Animal Model Products

miRNA for CHRNA7 Gene

miRTarBase miRNAs that target CHRNA7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNA7

Clone Products

  • R&D Systems cDNA Clones for CHRNA7 (Nicotinic Acetylcholine R alpha 7/CHRNA7)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CHRNA7 Gene

Localization for CHRNA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA7 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CHRNA7 Gene COMPARTMENTS Subcellular localization image for CHRNA7 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CHRNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005892 acetylcholine-gated channel complex IDA 8906617
GO:0009897 external side of plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with CHRNA7: view

Pathways & Interactions for CHRNA7 Gene

genes like me logo Genes that share pathways with CHRNA7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for CHRNA7 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CHRNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 10771023
GO:0001666 response to hypoxia IDA 12189247
GO:0001988 positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure IEA --
GO:0006810 transport --
GO:0006811 ion transport NAS 8906617
genes like me logo Genes that share ontologies with CHRNA7: view

Drugs & Compounds for CHRNA7 Gene

(88) Drugs for CHRNA7 Gene - From: NovoSeek, DGIdb, DrugBank, IUPHAR, ApexBio, Tocris, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Galantamine Approved Pharma Target, allosteric modulator 102
Nicotine Approved Pharma Activation, Activator, antagonist, Target, agonist 923
Ethanol Approved Pharma Target 1708
Mecamylamine Approved Pharma Channel blocker, antagonist 25
Butabarbital Approved, Illicit Pharma antagonist, Target 0

(28) Additional Compounds for CHRNA7 Gene - From: NovoSeek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-conotoxin ArIB
alpha-conotoxin ImI
genes like me logo Genes that share compounds with CHRNA7: view

Drug Products

Transcripts for CHRNA7 Gene

Unigene Clusters for CHRNA7 Gene

Cholinergic receptor, nicotinic, alpha 7 (neuronal):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNA7

Clone Products

  • R&D Systems cDNA Clones for CHRNA7 (Nicotinic Acetylcholine R alpha 7/CHRNA7)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA7 Gene

No ASD Table

Relevant External Links for CHRNA7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRNA7 Gene

mRNA expression in normal human tissues for CHRNA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CHRNA7 Gene Hs.511772

genes like me logo Genes that share expression patterns with CHRNA7: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CHRNA7 Gene

Orthologs for CHRNA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHRNA7 35
  • 87.93 (n)
  • 94.57 (a)
(Canis familiaris)
Mammalia CHRNA7 35
  • 91.18 (n)
  • 97.17 (a)
  • 97 (a)
(Mus musculus)
Mammalia Chrna7 35
  • 88.06 (n)
  • 93.96 (a)
Chrna7 16
Chrna7 36
  • 93 (a)
(Pan troglodytes)
Mammalia CHRNA7 35
  • 99.27 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Chrna7 35
  • 87.59 (n)
  • 93.96 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
(Gallus gallus)
Aves CHRNA7 35
  • 77.64 (n)
  • 90.91 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493611 35
  • 73.6 (n)
  • 85.25 (a)
(Danio rerio)
Actinopterygii chrna7 35
  • 71.53 (n)
  • 78.5 (a)
BX255960.1 36
  • 20 (a)
CABZ01069081.1 36
  • 74 (a)
CABZ01073083.1 36
  • 19 (a)
CABZ01088685.1 36
  • 85 (a)
chrna7 36
  • 75 (a)
si:ch211-256e16.6 36
  • 21 (a)
si:ch211-39a7.1 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta nAcRalpha-18C 37
  • 60 (a)
nAcRalpha-30D 37
  • 50 (a)
nAcRalpha-34E 37
  • 56 (a)
nAcRalpha-7E 37
  • 46 (a)
nAcRalpha-96Aa 37
  • 46 (a)
nAcRalpha-96Ab 37
  • 37 (a)
nAcRalpha-34E 35
  • 55.28 (n)
  • 51.25 (a)
gfA 36
  • 43 (a)
nAcRalpha-30D 36
  • 45 (a)
nAcRalpha-34E 36
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008588 35
  • 55.21 (n)
  • 50.83 (a)
(Caenorhabditis elegans)
Secernentea acr-10 37
  • 43 (a)
acr-11 37
  • 40 (a)
acr-12 37
  • 33 (a)
acr-14 37
  • 33 (a)
acr-15 37
  • 33 (a)
acr-16 37
  • 44 (a)
acr-17 37
  • 32 (a)
acr-18 37
  • 30 (a)
acr-19 37
  • 49 (a)
acr-22 37
  • 30 (a)
acr-5 37
  • 31 (a)
acr-7 37
  • 37 (a)
acr-8 37
  • 29 (a)
acr-9 37
  • 38 (a)
C04C3.2 37
  • 28 (a)
deg-3 37
  • 29 (a)
F18G5.4 37
  • 36 (a)
unc-29 37
  • 33 (a)
Y57G11C.2 37
  • 28 (a)
Y73F8A.30 37
  • 36 (a)
ZK973.5 37
  • 30 (a)
acr-16 35
  • 49.21 (n)
  • 45.57 (a)
acr-10 36
  • 31 (a)
acr-11 36
  • 41 (a)
acr-14 36
  • 33 (a)
acr-15 36
  • 34 (a)
acr-16 36
  • 44 (a)
acr-17 36
  • 25 (a)
acr-18 36
  • 25 (a)
acr-19 36
  • 41 (a)
acr-20 36
  • 23 (a)
acr-21 36
  • 33 (a)
acr-23 36
  • 23 (a)
acr-24 36
  • 23 (a)
acr-25 36
  • 33 (a)
acr-5 36
  • 21 (a)
acr-7 36
  • 33 (a)
acr-9 36
  • 36 (a)
deg-3 36
  • 25 (a)
des-2 36
  • 24 (a)
eat-2 36
  • 36 (a)
lgc-10 36
  • 21 (a)
lgc-11 36
  • 24 (a)
lgc-12 36
  • 25 (a)
lgc-13 36
  • 18 (a)
lgc-14 36
  • 18 (a)
lgc-15 36
  • 17 (a)
lgc-16 36
  • 19 (a)
lgc-17 36
  • 19 (a)
lgc-18 36
  • 19 (a)
lgc-19 36
  • 17 (a)
lgc-29 36
  • 17 (a)
lgc-30 36
  • 18 (a)
lgc-31 36
  • 17 (a)
lgc-4 36
  • 25 (a)
lgc-6 36
  • 21 (a)
lgc-7 36
  • 23 (a)
lgc-8 36
  • 23 (a)
lgc-9 36
  • 23 (a)
pbo-5 36
  • 21 (a)
pbo-6 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for CHRNA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA7 Gene

Gene Tree for CHRNA7 (if available)
Gene Tree for CHRNA7 (if available)

Paralogs for CHRNA7 Gene

Paralogs for CHRNA7 Gene

(17) SIMAP similar genes for CHRNA7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHRNA7: view

Variants for CHRNA7 Gene

Sequence variations from dbSNP and Humsavar for CHRNA7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs4779568 -- 32,125,669(+) TGATT(C/G/T)GATGT intron-variant
rs4779972 -- 32,057,788(+) CAGAT(A/G)TGTTG intron-variant
rs5811676 -- 32,043,250(+) ATTTT(-/A/AA)AAAAA intron-variant
rs5811678 -- 32,090,659(+) ATTCA(-/T)TTTTT intron-variant
rs5811679 -- 32,091,966(+) GTTTT(-/G)CTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHRNA7 Gene

Variant ID Type Subtype PubMed ID
dgv723e1 CNV Complex 17122850
dgv11e196 CNV Duplication 17116639
dgv2309n71 CNV Gain 21882294
dgv109e55 CNV Gain 17911159
nsv9237 CNV Gain+Loss 18304495
dgv724e1 CNV Complex 17122850
nsv428302 CNV Gain+Loss 18775914
esv33337 CNV Gain+Loss 17666407
dgv2310n71 CNV Gain 21882294
dgv306n27 CNV Gain 19166990
nsv471234 CNV Gain 18288195
nsv817680 CNV Gain 17921354
nsv517740 CNV Gain+Loss 19592680
nsv903860 CNV Loss 21882294
nsv821680 CNV Gain 15273396
nsv903877 CNV Gain 21882294
dgv2312n71 CNV Gain 21882294
dgv725e1 CNV Complex 17122850
nsv469870 CNV Gain 16826518
nsv471680 CNV Gain+Loss 15918152
dgv2314n71 CNV Gain 21882294
dgv2315n71 CNV Gain 21882294
nsv832956 CNV Gain 17160897
dgv2316n71 CNV Gain 21882294
nsv903902 CNV Gain 21882294
nsv819078 CNV Loss 19587683
esv2749539 CNV Deletion 23290073
esv2749540 CNV Deletion 23290073
esv2749542 CNV Deletion 23290073
esv2668191 CNV Deletion 23128226
dgv308n27 CNV Gain 19166990
nsv471681 CNV Gain+Loss 15918152
nsv903903 CNV Loss 21882294
dgv726e1 CNV Complex 17122850
dgv727e1 CNV Complex 17122850
dgv728e1 CNV Complex 17122850
nsv469726 CNV Loss 16826518
dgv2317n71 CNV Loss 21882294
dgv2318n71 CNV Loss 21882294
dgv2319n71 CNV Gain+Loss 21882294
dgv2320n71 CNV Gain+Loss 21882294
dgv2321n71 CNV Loss 21882294
esv25982 CNV Gain+Loss 19812545
nsv9238 CNV Gain+Loss 18304495
nsv903921 CNV Gain 21882294
dgv2322n71 CNV Loss 21882294

Variation tolerance for CHRNA7 Gene

Residual Variation Intolerance Score: 57.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRNA7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA7 Gene

Disorders for CHRNA7 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CHRNA7 Gene - From: GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
chrna7-related disorders
  • acetylcholine receptor, neuronal nicotinic receptor, neuronal nicotinic, alpha-7 subunit
15q13.3 microdeletion
  • chromosome 15q13.3 microdeletion syndrome
rasmussen encephalitis
  • re
cardiovascular disease risk factor )
  • coronary artery disease risk factor )
intermittent explosive disorder
  • explosive personality disorder
- elite association

Relevant External Links for CHRNA7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CHRNA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHRNA7 Gene

Publications for CHRNA7 Gene

  1. alpha7 nicotinic receptor gene promoter polymorphisms in inbred mice affect expression in a cell type-specific fashion. (PMID: 17360707) Mexal S. … Stitzel J.A. (J. Biol. Chem. 2007) 23 25 67
  2. Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. (PMID: 16754836) Olincy A. … Freedman R. (Arch. Gen. Psychiatry 2006) 23 25 67
  3. The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex. (PMID: 19690987) Wu H.Q. … Schwarcz R. (J. Mol. Neurosci. 2010) 23 67
  4. A 15q13.3 homozygous microdeletion associated with a severe neurodevelopmental disorder suggests putative functions of the TRPM1, CHRNA7, and other homozygously deleted genes. (PMID: 20425840) Lepichon J.B. … Yu S. (Am. J. Med. Genet. A 2010) 23 67
  5. Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulates nicotinic receptors in small airway epithelial cells. (PMID: 19896235) Al-Wadei H.A. … Schuller H.M. (Lung Cancer 2010) 23 67

Products for CHRNA7 Gene

Sources for CHRNA7 Gene

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