Aliases for CHRNA6 Gene
External Ids for CHRNA6 Gene
Previous GeneCards Identifiers for CHRNA6 Gene
This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]
GeneCards Summary for CHRNA6 Gene
CHRNA6 (Cholinergic Receptor, Nicotinic, Alpha 6 (Neuronal)) is a Protein Coding gene. Diseases associated with CHRNA6 include autosomal dominant nocturnal frontal lobe epilepsy and alcohol dependence. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include extracellular ligand-gated ion channel activity and acetylcholine receptor activity. An important paralog of this gene is CHRNA3.
UniProtKB/Swiss-Prot for CHRNA6 Gene
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane