CHRNA6 Gene
protein-coding GIFtS: 56
GCID: GC08M042625
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|
cholinergic receptor, nicotinic, alpha 6 (neuronal)(Previous names: cholinergic receptor, nicotinic, alpha polypeptide 6 )
| |
Aliases
for CHRNA6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cholinergic Receptor, Nicotinic, Alpha 6 (Neuronal)1 2 | | Cholinergic Receptor, Nicotinic, Alpha Polypeptide 61 2 | | CHNRA62 | | Acetylcholine Receptor, Nicotinic, Alpha 6 (Neuronal)2 | | Neuronal Acetylcholine Receptor Subunit Alpha-62 |
Export aliases for CHRNA6 gene to outside databasesPrevious GC identifers: GC08M042362 GC08M042677 GC08M042726 GC08M041129 |
Summaries
for CHRNA6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHRNA6:
This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of fivesubunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronalnicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine andexogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotidepolymorphisms in this gene have been associated with both nicotine and alcohol dependence. (provided by RefSeq, Dec2010)
UniProtKB/Swiss-Prot: ACHA6_HUMAN, Q15825Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects allsubunits and leads to opening of an ion-conducting channel across the plasma membrane
 summary
for CHRNA6: Nicotinic receptors (nAChRs) are ligand-gated ion channels that modulate cell membrane potentials. Each
receptor is composed of pentameric combinations of subunits (alpha1-10, beta1-4, delta, epsilon and gamma).
Nicotinic receptors are generally divided into three functional classes: muscle subunits (alpha1, beta1,
delta, epsilon, gamma), standard neuronal subunits (alpha1-6 and beta2-4) that form in pairwise alphabeta
combinations, and subunits (alpha7-9) that can form homomeric nAChRs. Neuronal nicotinic receptors are found
in the central nervous system and in autonomic ganglia where they regulate processes such as transmitter
release, cell excitability and neuronal integration. Nicotinic receptors located at the neuromuscular
junctions of somatic muscles are responsible for muscular contraction.
Gene Wiki entry for CHRNA6
|
Genomic Views
for CHRNA6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHRNA6 gene promoter:
AP-1 Bach2 STAT5A Cdc5 S8 PPAR-gamma1 POU2F1 POU2F1a STAT3 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHRNA6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRNA6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p11.21 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p22CHRNA6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M042625: view genomic region
(about GC identifiers)
Start:
|
42,607,763 bp from pter |
End:
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42,651,535 bp from pter |
Size:
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43,773 bases |
Orientation:
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minus strand |
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Proteins
for CHRNA6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACHA6_HUMAN, Q15825 (See
protein sequence)Recommended Name: Neuronal acetylcholine receptor subunit alpha-6 precursor Size: 494 amino acids; 56898 Da
Subunit: Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta)
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane;Multi-pass membrane protein
Secondary accessions: B2R8V4 B4DQH1Alternative splicing: 2 isoforms: Q15825-1 Q15825-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CHRNA6: NX_Q15825
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15825
CHRNA6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001186208.1 NP_004189.1
ENSEMBL proteins: ENSP00000276410 ENSP00000433871 ENSP00000434659 Reactome Protein details: Q15825
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CHRNA6 for ontologies About GeneDecksing
CHRNA6 Antibody Products:
Assay Products for CHRNA6: |
Protein
Domains /
Families
for CHRNA6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHRNA6 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15825ProtoNet protein and cluster: Q15825 2 Blocks protein families: IPB002394 Nicotinic acetylcholine receptor signature IPB006201 Neurotransmitter-gated ion-channel
UniProtKB/Swiss-Prot: ACHA6_HUMAN, Q15825Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.Alpha-6/CHRNA6 sub-subfamily |
Function
for CHRNA6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ACHA6_HUMAN, Q15825Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects allsubunits and leads to opening of an ion-conducting channel across the plasma membrane
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNA6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNA6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA6 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CHRNA6 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Chrna6tm1Nchx for CHRNA6
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Chrna6):
CHRNA6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CHRNA6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Presynaptic nicotinic acetylcholine receptors | | | 2 | Transmission across Chemical Synapses | | | 3 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | | | 4 | Calcium channels | | | 5 | CREB Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CHRNA6
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CHRNA6
1  BioSystems Pathway for CHRNA6
5/9 
Reactome Pathways for CHRNA6 (see all 9)
1  PharmGKB Pathway for CHRNA6
2 
Kegg Pathways (Kegg details for CHRNA6):
CHRNA6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHRNA6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/16 Interacting proteins for CHRNA6 (ENSP000002764104) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
CHRNA6 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHRNA6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for CHRNA6 available from Tocris Bioscience About this table
3 DrugBank Compounds for CHRNA6 About this table
Search CenterWatch for drugs/clinical trials and news about CHRNA6 / ACHA6
|
Transcripts
for CHRNA6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHRNA6 gene (2 alternative transcripts): NM_001199279.1 NM_004198.3 Unigene Cluster for CHRNA6: Cholinergic receptor, nicotinic, alpha 6 (neuronal) Hs.103128 [show with all ESTs]Unigene Representative Sequence: NM_0041985 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000276410(uc003xpj.3 uc011lcw.2) ENST00000534622 ENST00000533810
ENST00000530869 ENST00000529467
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNA6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNA6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CHRNA6 (NM_004198) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHRNA6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNA6 |
Additional cDNA sequence: AK298798.1 AK313521.1 BC014456.1 U62435.1 Y16282.1 1 DOTS entry: DT.91826338 12 AceView cDNA sequences: AL712887 Y16282 BX280945 BU739756 NM_004198 BC014456 U62435 BM716007 BF794323 BG763892 BF933609 BG761570
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA6 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CHRNA6
|
Expression
for CHRNA6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHRNA6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCTGTAAT
About this image
See CHRNA6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHRNA6
SOURCE GeneReport for Unigene cluster: Hs.103128
SABiosciences Expression via Pathway-Focused PCR Array including CHRNA6:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRNA6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHRNA6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRNA6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNA6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA6 |
Orthologs
for CHRNA6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CHRNA6 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CHRNA61 |
cholinergic receptor, nicotinic, alpha 6 |
75.65(n)
82.32(a) |
|
396321 NM_205364.1 NP_990695.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CHRNA66 |
-- |
79(a) |
1 ↔ 1 |
GL343339.1(753961-770510) |
zebrafish
(Danio rerio) |
Actinopterygii |
chrna61 |
cholinergic receptor, nicotinic, alpha 6 |
66.11(n)
71.55(a) |
|
555747 NM_001042684.1 NP_001036149.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
nAcRalpha-7E1 , 3 |
nicotinic acetylcholine-activated
cation-selective more3
nicotinic Acetylcholine Receptor alpha 7E1 |
55(a)
(best of 8)3
58.55(n)1
55.38(a)1 |
|
317671 NM_080340.31 NP_525079.31 |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-631 , 3 |
ion-channel protein3
Protein UNC-631 |
45(a)
(best of 24)3
55.81(n)1
50(a)1 |
|
I(5141683-5149120)3
1721501 NM_059132.31 NP_491533.21 |
ENSEMBL Gene Tree for CHRNA6 (if available)
TreeFam Gene Tree for CHRNA6 (if available) |
Paralogs
for CHRNA6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHRNA6 gene
- CHRNA52 CHRNA42 CHRNA102 CHRNA22 CHRNA92 CHRNB22 CHRNA12 CHRNG2
- CHRNA72 CHRNA32 CHRFAM7A2 CHRNE2 CHRND2 CHRNB12 CHRNB32 CHRNB42
18/20 SIMAP similar genes for CHRNA6 using alignment to 3 protein entries: ACHA6_HUMAN (see all proteins)
(see all similar genes):CHRNA3 CHRNA5 CHRNA2 CHRNB4 CHRNA1 CHRNB2
CHRNB3 CHRNA7-2 CHRNA9 CHRND CHRNB1 CHRFAM7A
CHRNA7 CHRNA4 HTR3A CHRNE GABRA6 CHRNA10
CHRNA6 for paralogs About GeneDecksing
|
Genomic Variants
for CHRNA6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHRNA6 (42607763 - 42651535 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHRNA6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHRNA6 |
|
Disorders
/ Diseases
for CHRNA6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHRNA6 for disorders About GeneDecksing
OMIM gene information: 606888
OMIM disorders: --
7  diseases for CHRNA6: About MalaCardsneuronitis nicotine dependence alcohol dependence alcoholism
parkinson's disease pharyngitis schizophrenia
1 disease from the University of Copenhagen DISEASES database for CHRNA6:Nicotine dependence Human Genome Epidemiology (HuGE) Navigator: CHRNA6 (18 documents)
Export disorders for CHRNA6 gene to outside databases
|
Publications
for CHRNA6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHRNA6 gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with CHRNA6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Comparative structure of human neuronal alpha 2-alpha 7 and beta 2- beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. (PubMed id 8906617)1, 2, 3 Elliott K.J.... Harpold M.M. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genomic organization and promoter analysis of the human nicotinic acetylcholine receptor alpha6 subunit (CHNRA6) gene: Alu and other elements direct transcriptional repression. (PubMed id 12406580)1, 9 Ebihara M....Yoshikawa T. (2002)
- Exclusion of linkage of nine neuronal nicotinic acetylcholine receptor subunit genes expressed in brain in autosomal dominant nocturnal frontal lobe epilepsy in four unrelated families. (PubMed id 12195439)1, 9 Bonati M.T....Tenchini M.L. (2002)
- Native a6b4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland. (PubMed id 21917987)1 Perez-Alvarez A....Albillos A. (2012)
- Modulation of gain-of-function a6*-nicotinic acetylcho line receptor by b3 subunits. (PubMed id 22315221)1 Dash B. and Lukas R.J. (2012)
- [Human chromosome 8p11 (CHRNB3-CHRNA6) region gene po lymorphisms and susceptibility to lung cancer in Chinese Han population]. (PubMed id 21831805)1 Zhang X.B....Lu D.R. (2011)
- Identification of N-terminal extracellular domain det erminants in nicotinic acetylcholine receptor (nAChR) I+6 subunits that influenc e effects of wild-type or mutant I^3 subunits on function of I+6I^2*- or I+6I^4*-nAC hR. (PubMed id 21832048)1 Dash B....Lukas R.J. (2011)
- Reporter mutation studies show that nicotinic acetylc holine receptor (nAChR) I+5 Subunits and/or variants modulate function of I+6*-nA ChR. (PubMed id 21873428)1 Dash B....Lukas R.J. (2011)
- Expression of functional human I+6I^2I^3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and conca tamers. (PubMed id 20923852)1 Kuryatov A. and Lindstrom J. (2011)
|
External Searches for CHRNA6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHRNA6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHRNA6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHRNA6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHRNA6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CHRNA6 gene:
Search GeneIP for patents involving CHRNA6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHRNA6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHRNA6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHRNA6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRNA6 | | | OriGene Protein Over-expression Lysate for CHRNA6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHRNA6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNA6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNA6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHRNA6 | | OriGene Custom Protein Services for CHRNA6 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHRNA6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHRNA6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRNA6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRNA6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNA6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRNA6 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA6 |
|  |  |  | | | | Search ThermoFisher Antibodies for CHRNA6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNA6 |
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