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Aliases for CHRNA6 Gene

Aliases for CHRNA6 Gene

  • Cholinergic Receptor, Nicotinic, Alpha 6 (Neuronal) 2 3
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 6 2 3
  • Acetylcholine Receptor, Nicotinic, Alpha 6 (Neuronal) 3
  • Neuronal Acetylcholine Receptor Subunit Alpha-6 3
  • Acetylcholine Receptor 2
  • Alpha 6 (Neuronal) 2
  • Nicotinic 2
  • CHNRA6 3

External Ids for CHRNA6 Gene

Previous GeneCards Identifiers for CHRNA6 Gene

  • GC08M042362
  • GC08M042677
  • GC08M042625
  • GC08M041129

Summaries for CHRNA6 Gene

Entrez Gene Summary for CHRNA6 Gene

  • This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]

GeneCards Summary for CHRNA6 Gene

CHRNA6 (Cholinergic Receptor, Nicotinic, Alpha 6 (Neuronal)) is a Protein Coding gene. Diseases associated with CHRNA6 include autosomal dominant nocturnal frontal lobe epilepsy and frontal lobe epilepsy. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and acetylcholine receptor activity. An important paralog of this gene is CHRNA3.

UniProtKB/Swiss-Prot for CHRNA6 Gene

  • After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Gene Wiki entry for CHRNA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA6 Gene

Genomics for CHRNA6 Gene

Regulatory Elements for CHRNA6 Gene

Genomic Location for CHRNA6 Gene

42,752,620 bp from pter
42,796,392 bp from pter
43,773 bases
Minus strand

Genomic View for CHRNA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRNA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA6 Gene

Proteins for CHRNA6 Gene

  • Protein details for CHRNA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-6
    Protein Accession:
    Secondary Accessions:
    • B2R8V4
    • B4DQH1

    Protein attributes for CHRNA6 Gene

    494 amino acids
    Molecular mass:
    56898 Da
    Quaternary structure:
    • Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta)

    Alternative splice isoforms for CHRNA6 Gene


neXtProt entry for CHRNA6 Gene

Proteomics data for CHRNA6 Gene at MOPED

Post-translational modifications for CHRNA6 Gene

  • Glycosylation at Asn54 and Asn171
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNA6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHRNA6 Gene

Domains for CHRNA6 Gene

Gene Families for CHRNA6 Gene

  • CHR :Cholinergic receptors
  • CHRN :Ligand-gated ion channels / Acetylcholine receptors, nicotinic

Graphical View of Domain Structure for InterPro Entry



  • Q15825
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub-subfamily.
genes like me logo Genes that share domains with CHRNA6: view

Function for CHRNA6 Gene

Molecular function for CHRNA6 Gene

UniProtKB/Swiss-Prot Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Gene Ontology (GO) - Molecular Function for CHRNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004889 acetylcholine-activated cation-selective channel activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0005515 protein binding --
GO:0015464 acetylcholine receptor activity TAS 8906617
genes like me logo Genes that share ontologies with CHRNA6: view

Phenotypes for CHRNA6 Gene

MGI mutant phenotypes for CHRNA6:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CHRNA6: view

Animal Models for CHRNA6 Gene

MGI Knock Outs for CHRNA6:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNA6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CHRNA6 Gene

Localization for CHRNA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA6 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CHRNA6 Gene COMPARTMENTS Subcellular localization image for CHRNA6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CHRNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005892 acetylcholine-gated channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CHRNA6: view

Pathways for CHRNA6 Gene

genes like me logo Genes that share pathways with CHRNA6: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CHRNA6 Gene

Gene Ontology (GO) - Biological Process for CHRNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8906617
GO:0006811 ion transport --
GO:0006812 cation transport --
GO:0007165 signal transduction TAS 8906617
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with CHRNA6: view

Compounds for CHRNA6 Gene

(1) ApexBio Compounds for CHRNA6 Gene

Compound Action Cas Number
Adiphenine HCl [50-42-0]

(3) Drugbank Compounds for CHRNA6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • (-)-Galanthamine
357-70-0 target allosteric modulator
  • L-Nicotine
54-11-5 target agonist
  • CP-526,555
249296-44-4 target partial agonist

(6) IUPHAR Ligand for CHRNA6 Gene

Ligand Type Action Affinity Pubmed IDs
mecamylamine Channel blocker None 6.41
hexamethonium Channel blocker None
alpha-conotoxin MII [H9A, L15A] Antagonist Antagonist
alpha-conotoxin MII Antagonist Antagonist
[125I]alpha-conotoxin MII None None
alpha-conotoxin PIA Antagonist Antagonist
genes like me logo Genes that share compounds with CHRNA6: view

Transcripts for CHRNA6 Gene

mRNA/cDNA for CHRNA6 Gene

(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHRNA6 Gene

Cholinergic receptor, nicotinic, alpha 6 (neuronal):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNA6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2: -

Relevant External Links for CHRNA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRNA6 Gene

mRNA expression in normal human tissues for CHRNA6 Gene

mRNA differential expression in normal tissues according to GTEx for CHRNA6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (10.0), Brain - Substantia nigra (7.0), and Brain - Cerebellum (6.9).

Protein differential expression in normal tissues for CHRNA6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHRNA6 Gene

SOURCE GeneReport for Unigene cluster for CHRNA6 Gene Hs.103128

genes like me logo Genes that share expressions with CHRNA6: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CHRNA6 Gene

Orthologs for CHRNA6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHRNA6 35
  • 84.41 (n)
  • 87.25 (a)
  • 87 (a)
(Canis familiaris)
Mammalia CHRNA6 35
  • 87.58 (n)
  • 88.66 (a)
  • 89 (a)
(Mus musculus)
Mammalia Chrna6 35
  • 81.85 (n)
  • 85.02 (a)
Chrna6 16
Chrna6 36
  • 85 (a)
(Pan troglodytes)
Mammalia CHRNA6 35
  • 99.6 (n)
  • 99.6 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Chrna6 35
  • 81.95 (n)
  • 84.79 (a)
(Monodelphis domestica)
Mammalia CHRNA6 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia CHRNA6 36
  • 82 (a)
(Gallus gallus)
Aves CHRNA6 35
  • 75.65 (n)
  • 82.32 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia CHRNA6 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495287 35
  • 69.63 (n)
  • 72.21 (a)
(Danio rerio)
Actinopterygii chrna6 35
  • 66.11 (n)
  • 71.55 (a)
chrna6 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta nAcRalpha-30D 37
  • 30 (a)
nAcRalpha-7E 37
  • 55 (a)
nAcRalpha-80B 37
  • 40 (a)
nAcRalpha-96Aa 37
  • 50 (a)
nAcRalpha-96Ab 37
  • 50 (a)
nAcRbgr-21C 37
  • 28 (a)
nAcRbgr-64B 37
  • 43 (a)
nAcRbgr-96A 37
  • 45 (a)
nAcRalpha-7E 35
  • 58.02 (n)
  • 54.11 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000329 35
  • 58.48 (n)
  • 54.73 (a)
(Caenorhabditis elegans)
Secernentea acr-10 37
  • 41 (a)
acr-12 37
  • 39 (a)
acr-13 37
  • 30 (a)
acr-14 37
  • 29 (a)
acr-15 37
  • 32 (a)
acr-17 37
  • 28 (a)
acr-18 37
  • 24 (a)
acr-2 37
  • 39 (a)
acr-22 37
  • 30 (a)
acr-23 37
  • 27 (a)
acr-3 37
  • 40 (a)
acr-5 37
  • 30 (a)
acr-7 37
  • 36 (a)
acr-8 37
  • 33 (a)
deg-3 37
  • 26 (a)
F18G5.4 37
  • 32 (a)
lev-1 37
  • 38 (a)
unc-29 37
  • 39 (a)
unc-38 37
  • 41 (a)
unc-63 37
  • 45 (a)
Y44A6E.1 37
  • 28 (a)
Y57G11C.2 37
  • 25 (a)
Y73F8A.30 37
  • 31 (a)
ZK973.5 37
  • 36 (a)
unc-38 35
  • 55.65 (n)
  • 46.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for CHRNA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA6 Gene

Gene Tree for CHRNA6 (if available)
Gene Tree for CHRNA6 (if available)

Paralogs for CHRNA6 Gene

genes like me logo Genes that share paralogs with CHRNA6: view

Variants for CHRNA6 Gene

Sequence variations from dbSNP and Humsavar for CHRNA6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs892413 -- 42,759,235(+) GACTT(A/C)AAGGC intron-variant
rs1072003 -- 42,764,858(+) GTAAA(C/G)TGGTT intron-variant
rs2196128 -- 42,763,143(+) AACCA(C/T)GAAGC intron-variant
rs2196129 -- 42,763,263(+) GGAGT(C/G)ACATC intron-variant
rs2217732 -- 42,763,303(+) CAACT(A/G)AACAT intron-variant

Relevant External Links for CHRNA6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CHRNA6 Gene

Disorders for CHRNA6 Gene

(1) University of Copenhagen DISEASES for CHRNA6 Gene

Relevant External Links for CHRNA6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CHRNA6: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CHRNA6 Gene

Publications for CHRNA6 Gene

  1. Comparative structure of human neuronal alpha 2-alpha 7 and beta 2- beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. (PMID: 8906617) Elliott K.J. … Harpold M.M. (J. Mol. Neurosci. 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. (PMID: 20418888) Thorgeirsson T.E. … Stefansson K. (Nat. Genet. 2010) 3 48
  4. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (PMID: 20584212) Saccone N.L. … Bierut L.J. (Genes Brain Behav. 2010) 3 48
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 48

Products for CHRNA6 Gene

Sources for CHRNA6 Gene

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