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Aliases for CHRNA5 Gene

Aliases for CHRNA5 Gene

  • Cholinergic Receptor, Nicotinic, Alpha 5 (Neuronal) 2 3
  • LNCR2 3 6
  • Cholinergic Receptor, Neuronal Nicotinic, Alpha Polypeptide-5 3
  • Neuronal Nicotinic Acetylcholine Receptor, Alpha5 Subunit 3
  • Acetylcholine Receptor, Nicotinic, Alpha 5 (Neuronal) 3
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 5 2
  • Neuronal Acetylcholine Receptor Subunit Alpha-5 3
  • Acetylcholine Receptor 2
  • Alpha 5 (Neuronal) 2
  • Nicotinic 2
  • NACHRA5 4

External Ids for CHRNA5 Gene

Previous GeneCards Identifiers for CHRNA5 Gene

  • GC15P074936
  • GC15P071947
  • GC15P076433
  • GC15P076573
  • GC15P076644
  • GC15P078857
  • GC15P055614

Summaries for CHRNA5 Gene

Entrez Gene Summary for CHRNA5 Gene

  • The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

GeneCards Summary for CHRNA5 Gene

CHRNA5 (Cholinergic Receptor, Nicotinic, Alpha 5 (Neuronal)) is a Protein Coding gene. Diseases associated with CHRNA5 include lung cancer susceptibility 2 and frontal lobe epilepsy. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and ligand-gated ion channel activity. An important paralog of this gene is CHRNA3.

UniProtKB/Swiss-Prot for CHRNA5 Gene

  • After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Gene Wiki entry for CHRNA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA5 Gene

Genomics for CHRNA5 Gene

Regulatory Elements for CHRNA5 Gene

Genomic Location for CHRNA5 Gene

Start:
78,565,520 bp from pter
End:
78,595,269 bp from pter
Size:
29,750 bases
Orientation:
Plus strand

Genomic View for CHRNA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA5 Gene

Proteins for CHRNA5 Gene

  • Protein details for CHRNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30532-ACHA5_HUMAN
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-5
    Protein Accession:
    P30532
    Secondary Accessions:
    • Q15824
    • Q99554

    Protein attributes for CHRNA5 Gene

    Size:
    468 amino acids
    Molecular mass:
    53054 Da
    Quaternary structure:
    • Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta)

neXtProt entry for CHRNA5 Gene

Proteomics data for CHRNA5 Gene at MOPED

Post-translational modifications for CHRNA5 Gene

  • Ubiquitination at Lys119 and Lys377
  • Glycosylation at Asn155, Asn183, and Asn229
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNA5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHRNA5 Gene

Domains for CHRNA5 Gene

Gene Families for CHRNA5 Gene

HGNC:
  • CHR :Cholinergic receptors
  • CHRN :Ligand-gated ion channels / Acetylcholine receptors, nicotinic
IUPHAR :

Suggested Antigen Peptide Sequences for CHRNA5 Gene

Graphical View of Domain Structure for InterPro Entry

P30532

UniProtKB/Swiss-Prot:

ACHA5_HUMAN :
  • P30532
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
genes like me logo Genes that share domains with CHRNA5: view

Function for CHRNA5 Gene

Molecular function for CHRNA5 Gene

GENATLAS Biochemistry: cholinergic receptor,nicotinic,alpha 5 polypeptide,neuronal
UniProtKB/Swiss-Prot Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Gene Ontology (GO) - Molecular Function for CHRNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004889 acetylcholine-activated cation-selective channel activity TAS 20438829
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0015276 ligand-gated ion channel activity TAS 20438829
GO:0015464 acetylcholine receptor activity IDA 1542648
genes like me logo Genes that share ontologies with CHRNA5: view

Phenotypes for CHRNA5 Gene

MGI mutant phenotypes for CHRNA5:
inferred from 1 alleles
GenomeRNAi human phenotypes for CHRNA5:
genes like me logo Genes that share phenotypes with CHRNA5: view

Animal Models for CHRNA5 Gene

MGI Knock Outs for CHRNA5:

Animal Model Products

CRISPR Products

miRNA for CHRNA5 Gene

miRTarBase miRNAs that target CHRNA5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CHRNA5 Gene

Localization for CHRNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA5 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRNA5 Gene COMPARTMENTS Subcellular localization image for CHRNA5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CHRNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005892 acetylcholine-gated channel complex IC 1542648
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CHRNA5: view

Pathways for CHRNA5 Gene

genes like me logo Genes that share pathways with CHRNA5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHRNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport NAS 1542648
GO:0006811 ion transport --
GO:0006812 cation transport TAS 20438829
GO:0007165 signal transduction NAS 9009220
GO:0007268 synaptic transmission TAS 9009220
genes like me logo Genes that share ontologies with CHRNA5: view

Compounds for CHRNA5 Gene

(2) Drugbank Compounds for CHRNA5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Galantamine
  • (-)-Galanthamine
357-70-0 target allosteric modulator
Nicotine
  • L-Nicotine
54-11-5 target agonist

(4) IUPHAR Ligand for CHRNA5 Gene

Ligand Type Action Affinity Pubmed IDs
alpha-conotoxin-GIC Antagonist Antagonist
alpha-conotoxin TxIA Antagonist Antagonist
alpha-conotoxin MII Antagonist Antagonist
alpha-conotoxin PnIA Antagonist Antagonist

(2) PharmGKB related drug/compound annotations for CHRNA5 Gene

Drug/compound Annotation
Drugs used in nicotine dependence CA
nicotine CA
genes like me logo Genes that share compounds with CHRNA5: view

Transcripts for CHRNA5 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNA5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA5 Gene

No ASD Table

Relevant External Links for CHRNA5 Gene

GeneLoc Exon Structure for
CHRNA5
ECgene alternative splicing isoforms for
CHRNA5

Expression for CHRNA5 Gene

mRNA expression in normal human tissues for CHRNA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHRNA5 Gene

SOURCE GeneReport for Unigene cluster for CHRNA5 Gene Hs.1614

genes like me logo Genes that share expressions with CHRNA5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHRNA5 Gene

Orthologs for CHRNA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRNA5 35
  • 99.43 (n)
  • 98.93 (a)
CHRNA5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHRNA5 35
  • 89.58 (n)
  • 90.52 (a)
CHRNA5 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRNA5 35
  • 83.26 (n)
  • 91.44 (a)
CHRNA5 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrna5 35
  • 84.46 (n)
  • 90.91 (a)
Chrna5 16
Chrna5 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHRNA5 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHRNA5 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrna5 35
  • 84.07 (n)
  • 91.84 (a)
chicken
(Gallus gallus)
Aves CHRNA5 35
  • 80.47 (n)
  • 86.98 (a)
CHRNA5 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chrna5 35
  • 75.23 (n)
  • 85.05 (a)
Str.13533 35
zebrafish
(Danio rerio)
Actinopterygii chrna5 35
  • 69.29 (n)
  • 77.14 (a)
chrna5 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nAcRalpha-96Aa 37
  • 50 (a)
nAcRalpha-96Ab 37
  • 48 (a)
nAcRalpha-30D 37
  • 46 (a)
nAcRbgr-96A 37
  • 42 (a)
nAcRbgr-21C 37
  • 28 (a)
nAcRalpha-7E 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea acr-13 37
  • 31 (a)
C04C3.2 37
  • 25 (a)
unc-63 37
  • 43 (a)
ZK973.5 37
  • 35 (a)
acr-8 37
  • 31 (a)
Species with no ortholog for CHRNA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA5 Gene

ENSEMBL:
Gene Tree for CHRNA5 (if available)
TreeFam:
Gene Tree for CHRNA5 (if available)

Paralogs for CHRNA5 Gene

genes like me logo Genes that share paralogs with CHRNA5: view

Variants for CHRNA5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA5 Gene

P30532-ACHA5_HUMAN
Genetic variations in CHRNA5 have been associated with susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3 (SQTL3) [MIM:612052]

Sequence variations from dbSNP and Humsavar for CHRNA5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs471889 -- 78,577,893(-) AGTGC(A/G)ATGGT intron-variant
rs479385 -- 78,572,384(+) ATTAG(A/T)CTTTA intron-variant
rs481134 -- 78,585,221(-) AACAC(C/T)AGAGC intron-variant
rs495090 -- 78,577,661(-) GTCAC(C/T)GCACC intron-variant
rs495956 -- 78,577,588(-) CTTGA(A/G)TCGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHRNA5 Gene

Variant ID Type Subtype PubMed ID
nsv518840 CNV Loss 19592680

Relevant External Links for CHRNA5 Gene

HapMap Linkage Disequilibrium report
CHRNA5
Human Gene Mutation Database (HGMD)
CHRNA5

Disorders for CHRNA5 Gene

(2) OMIM Diseases for CHRNA5 Gene (118505)

Relevant External Links for CHRNA5

Genetic Association Database (GAD)
CHRNA5
Human Genome Epidemiology (HuGE) Navigator
CHRNA5
genes like me logo Genes that share disorders with CHRNA5: view

No data available for UniProtKB/Swiss-Prot for CHRNA5 Gene

Publications for CHRNA5 Gene

  1. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PMID: 17559419) Rigbi A. … Lerer B. (Genes Brain Behav. 2008) 3 23 48
  2. A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. (PMID: 18519132) Grucza R.A. … Bierut L.J. (Biol. Psychiatry 2008) 3 23 48
  3. Variants in nicotinic receptors and risk for nicotine dependence. (PMID: 18519524) Bierut L.J. … Goate A.M. (Am J Psychiatry 2008) 3 23 48
  4. Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking. (PMID: 18783506) Sherva R. … Pomerleau O.F. (Addiction 2008) 3 23 48
  5. Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes. (PMID: 18996504) Breitling L.P. … Brenner H. (Biol. Psychiatry 2009) 3 23 48

Products for CHRNA5 Gene

Sources for CHRNA5 Gene

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