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Aliases for CHRNA4 Gene

Aliases for CHRNA4 Gene

  • Cholinergic Receptor Nicotinic Alpha 4 Subunit 2 3
  • Cholinergic Receptor, Nicotinic Alpha 4 2 3 5
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 4 2 3
  • Cholinergic Receptor, Nicotinic, Alpha 4 (Neuronal) 2 3
  • NACRA4 3 4
  • Neuronal Nicotinic Acetylcholine Receptor Alpha-4 Subunit 3
  • Acetylcholine Receptor 2
  • Alpha 4 (Neuronal) 2
  • Nicotinic 2
  • NACHRA4 3
  • NACHR 3
  • BFNC 3
  • EBN1 3
  • EBN 3

External Ids for CHRNA4 Gene

Previous HGNC Symbols for CHRNA4 Gene

  • EBN
  • EBN1

Previous GeneCards Identifiers for CHRNA4 Gene

  • GC20U990005
  • GC20M061813
  • GC20M062655
  • GC20M062702
  • GC20M061446
  • GC20M061974
  • GC20M058700

Summaries for CHRNA4 Gene

Entrez Gene Summary for CHRNA4 Gene

  • This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

GeneCards Summary for CHRNA4 Gene

CHRNA4 (Cholinergic Receptor Nicotinic Alpha 4 Subunit) is a Protein Coding gene. Diseases associated with CHRNA4 include epilepsy, nocturnal frontal lobe, 1 and autosomal dominant nocturnal frontal lobe epilepsy. Among its related pathways are Transmission across Chemical Synapses and SIDS Susceptibility Pathways. GO annotations related to this gene include ion channel activity and acetylcholine-activated cation-selective channel activity. An important paralog of this gene is CHRNA3.

UniProtKB/Swiss-Prot for CHRNA4 Gene

  • After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.

Tocris Summary for CHRNA4 Gene

  • Nicotinic alpha4beta2 receptors have high affinity for nicotine and account for >90% of [3H]-nicotine binding to brain tissues. A stoichiometry of (alpha4)2(beta2)3 has been proposed, generating two agonist binding sites consistent with the model of the muscle nAChR.

Gene Wiki entry for CHRNA4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA4 Gene

Genomics for CHRNA4 Gene

Regulatory Elements for CHRNA4 Gene

Genomic Location for CHRNA4 Gene

Chromosome:
20
Start:
63,343,223 bp from pter
End:
63,378,401 bp from pter
Size:
35,179 bases
Orientation:
Minus strand

Genomic View for CHRNA4 Gene

Genes around CHRNA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRNA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA4 Gene

Proteins for CHRNA4 Gene

  • Protein details for CHRNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43681-ACHA4_HUMAN
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-4
    Protein Accession:
    P43681
    Secondary Accessions:
    • Q4JGR7
    • Q4VAQ5
    • Q4VAQ6

    Protein attributes for CHRNA4 Gene

    Size:
    627 amino acids
    Molecular mass:
    69957 Da
    Quaternary structure:
    • Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Interacts with RIC3; which is required for proper folding and assembly.

    Three dimensional structures from OCA and Proteopedia for CHRNA4 Gene

    Alternative splice isoforms for CHRNA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHRNA4 Gene

Proteomics data for CHRNA4 Gene at MOPED

Post-translational modifications for CHRNA4 Gene

  • Glycosylation at Asn 57, Asn 107, and Asn 174
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNA4 Gene

Antibody Products

No data available for DME Specific Peptides for CHRNA4 Gene

Domains & Families for CHRNA4 Gene

Gene Families for CHRNA4 Gene

Graphical View of Domain Structure for InterPro Entry

P43681

UniProtKB/Swiss-Prot:

ACHA4_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.
genes like me logo Genes that share domains with CHRNA4: view

Function for CHRNA4 Gene

Molecular function for CHRNA4 Gene

GENATLAS Biochemistry:
cholinergic receptor,nicotinic,alpha 4 polypeptide,neuronal
UniProtKB/Swiss-Prot Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.

Gene Ontology (GO) - Molecular Function for CHRNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0015464 acetylcholine receptor activity IDA 8906617
genes like me logo Genes that share ontologies with CHRNA4: view
genes like me logo Genes that share phenotypes with CHRNA4: view

Human Phenotype Ontology for CHRNA4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CHRNA4 Gene

MGI Knock Outs for CHRNA4:

Animal Model Products

miRNA for CHRNA4 Gene

miRTarBase miRNAs that target CHRNA4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CHRNA4 Gene

Localization for CHRNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA4 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRNA4 Gene COMPARTMENTS Subcellular localization image for CHRNA4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CHRNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 8906617
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with CHRNA4: view

Pathways & Interactions for CHRNA4 Gene

genes like me logo Genes that share pathways with CHRNA4: view

Gene Ontology (GO) - Biological Process for CHRNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential ISS --
GO:0001666 response to hypoxia IDA 12189247
GO:0006810 transport IEA --
GO:0006811 ion transport IEA,NAS 8906617
GO:0006816 calcium ion transport ISS --
genes like me logo Genes that share ontologies with CHRNA4: view

No data available for SIGNOR curated interactions for CHRNA4 Gene

Drugs & Compounds for CHRNA4 Gene

(82) Drugs for CHRNA4 Gene - From: IUPHAR, DGIdb, DrugBank, Novoseek, PharmGKB, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotine Approved Pharma Antagonist, antagonist, Target, agonist 973
Varenicline Approved, Investigational Pharma agonist, Target, partial agonist 255
Ethanol Approved Pharma Target 1839
Butabarbital Approved, Illicit Pharma antagonist, Target 0
Butalbital Approved, Illicit Pharma antagonist, Target 0

(7) Additional Compounds for CHRNA4 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TC-2403
Full agonist, Agonist
(-)-Nicotine ditartrate
65-31-6
5-Iodo-A-85380 dihydrochloride
1217837-17-6
5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
213766-21-3
RJR 2403 oxalate
220662-95-3

(5) Tocris Compounds for CHRNA4 Gene

Compound Action Cas Number
(-)-Nicotine ditartrate Prototypical nAChR agonist 65-31-6
5-Iodo-A-85380 dihydrochloride High affinity alpha4beta2 and alpha6beta2 subtype-selective agonist 1217837-17-6
5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative Precursor to 5-Iodo-A-85380 (Cat. No. 1518) 213766-21-3
RJR 2403 oxalate alpha4beta2 selective nicotinic agonist 220662-95-3
TC 2559 difumarate Selective partial agonist at alpha4beta2 receptors 212332-35-9

(35) ApexBio Compounds for CHRNA4 Gene

Compound Action Cas Number
Acetylcholine Chloride Major transmitter at many nervous sites 60-31-1
Acetylcysteine Antioxidant;mucolytic agent 616-91-1
Adiphenine HCl 50-42-0
Atropine MAChRs antagonist 5908-99-6
Bethanechol chloride Muscarinic receptor agonist 590-63-6
Catharanthine 2468-21-5
Decamethonium Bromide 541-22-0
Diphemanil Methylsulfate 62-97-5
Flavoxate hydrochloride 3717-88-2
Galanthamine HBr Acetylcholinesterase inhibitor 1953-04-4
Gallamine Triethiodide 65-29-2
Hexamethonium Bromide 55-97-0
Homatropine Bromide Muscarinic AChR antagonist 51-56-9
Homatropine Methylbromide Muscarinic AChR antagonist 80-49-9
Hyoscyamine 101-31-5
Ipratropium Bromide 22254-24-6
LY2119620 886047-22-9
Methscopolamine Muscarinic acetylcholine receptor blocker 155-41-9
Neostigmine Bromide Cholinesterase inhibitor 114-80-7
Nitenpyram 150824-47-8
Orphenadrine Citrate Antiparkinsonian and analgesic drug 4682-36-4
Otilonium Bromide 26095-59-0
Oxybutynin 5633-20-5
Oxybutynin chloride 1508-65-2
Pancuronium dibromide AChR antagonist 15500-66-0
Paroxetine HCl Antidepressant agents 78246-49-8
PNU-120596 α7 nAChR modulator,positive allosteric 501925-31-1
Pregnenolone 145-13-1
Rivastigmine Tartrate 129101-54-8
Rocuronium Bromide TGF-βR I kinase inhibitor 119302-91-9
Succinylcholine Chloride Dihydrate 6101-15-1
Tiotropium Bromide hydrate Muscarinic antagonist 139404-48-1
Tropicamide Antimuscarinic drug 1508-75-4
Varenicline Tartrate Subtype-selective agonist of α4β2 nicotinic receptors,orally active 375815-87-5
vinblastine 865-21-4
genes like me logo Genes that share compounds with CHRNA4: view

Transcripts for CHRNA4 Gene

Unigene Clusters for CHRNA4 Gene

Cholinergic receptor, nicotinic, alpha 4 (neuronal):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for CHRNA4 Gene

GeneLoc Exon Structure for
CHRNA4
ECgene alternative splicing isoforms for
CHRNA4

Expression for CHRNA4 Gene

mRNA expression in normal human tissues for CHRNA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHRNA4 Gene

This gene is overexpressed in Liver (x18.5) and Brain - Substantia nigra (x4.3).

Protein differential expression in normal tissues from HIPED for CHRNA4 Gene

This gene is overexpressed in Heart (59.6) and Adipocyte (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRNA4 Gene



SOURCE GeneReport for Unigene cluster for CHRNA4 Gene Hs.10734

genes like me logo Genes that share expression patterns with CHRNA4: view

Protein tissue co-expression partners for CHRNA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CHRNA4 Gene

Orthologs for CHRNA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHRNA4 35
  • 85.75 (n)
  • 85.97 (a)
CHRNA4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRNA4 35
  • 88.87 (n)
  • 88.98 (a)
CHRNA4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrna4 35
  • 83.64 (n)
  • 85.48 (a)
Chrna4 16
Chrna4 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHRNA4 35
  • 98.51 (n)
  • 98.41 (a)
CHRNA4 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrna4 35
  • 83.92 (n)
  • 85.14 (a)
oppossum
(Monodelphis domestica)
Mammalia CHRNA4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHRNA4 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHRNA4 35
  • 75.82 (n)
  • 78.64 (a)
CHRNA4 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHRNA4 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chrna4 35
  • 70.94 (n)
  • 74.54 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC563696 35
  • 68.74 (n)
  • 69.68 (a)
CHRNA4 (3 of 3) 36
  • 59 (a)
OneToMany
chrna4b 36
  • 61 (a)
OneToMany
chrna4b 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nAcRalpha-30D 37
  • 35 (a)
nAcRalpha-7E 37
  • 52 (a)
nAcRalpha-96Aa 37
  • 58 (a)
nAcRalpha-96Ab 37
  • 55 (a)
nAcRbgr-21C 37
  • 30 (a)
nAcRbgr-64B 37
  • 51 (a)
nAcRbgr-96A 37
  • 51 (a)
nAcRbeta-64B 35
  • 60.93 (n)
  • 53.16 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000966 35
  • 59.41 (n)
  • 49.05 (a)
worm
(Caenorhabditis elegans)
Secernentea acr-10 37
  • 37 (a)
acr-12 37
  • 45 (a)
acr-13 37
  • 37 (a)
acr-14 37
  • 33 (a)
acr-15 37
  • 38 (a)
acr-17 37
  • 31 (a)
acr-18 37
  • 29 (a)
acr-2 37
  • 45 (a)
acr-22 37
  • 29 (a)
acr-23 37
  • 30 (a)
acr-3 37
  • 46 (a)
acr-5 37
  • 29 (a)
acr-7 37
  • 38 (a)
acr-8 37
  • 38 (a)
C04C3.2 37
  • 25 (a)
deg-3 37
  • 31 (a)
lev-1 37
  • 46 (a)
unc-29 37
  • 43 (a)
unc-38 37
  • 49 (a)
unc-63 37
  • 52 (a)
Y44A6E.1 37
  • 29 (a)
Y57G11C.2 37
  • 24 (a)
Y73F8A.30 37
  • 31 (a)
ZK973.5 37
  • 37 (a)
Species with no ortholog for CHRNA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA4 Gene

ENSEMBL:
Gene Tree for CHRNA4 (if available)
TreeFam:
Gene Tree for CHRNA4 (if available)

Paralogs for CHRNA4 Gene

genes like me logo Genes that share paralogs with CHRNA4: view

Variants for CHRNA4 Gene

Sequence variations from dbSNP and Humsavar for CHRNA4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_000295 Epilepsy, nocturnal frontal lobe, 1 (ENFL1)
VAR_017531 Epilepsy, nocturnal frontal lobe, 1 (ENFL1)
rs45604738 - 63,350,251(-) GCCCG(A/G)GCCAG nc-transcript-variant, reference, missense
rs45622132 - 63,349,861(-) CCACT(C/T)GGCTG nc-transcript-variant, reference, missense
rs1044393 -- 63,350,772(-) GTGGA(C/T)GCCGT nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CHRNA4 Gene

Variant ID Type Subtype PubMed ID
nsv913073 CNV Loss 21882294
nsv9825 CNV Gain 18304495
dgv4618n71 CNV Loss 21882294
nsv913165 CNV Loss 21882294
nsv913166 CNV Loss 21882294
nsv913177 CNV Loss 21882294
dgv4630n71 CNV Loss 21882294
dgv4631n71 CNV Loss 21882294
nsv913183 CNV Loss 21882294
dgv4632n71 CNV Loss 21882294
nsv913188 CNV Gain 21882294
nsv913189 CNV Loss 21882294
nsv913190 CNV Loss 21882294
dgv4633n71 CNV Loss 21882294
nsv828799 CNV Gain 20364138
nsv180574 CNV Insertion 16902084
esv1436907 CNV Insertion 17803354
esv1443132 CNV Insertion 17803354
esv1299744 CNV Insertion 17803354
esv1058695 CNV Insertion 17803354
dgv722e201 CNV Deletion 23290073
esv1955955 CNV Deletion 18987734
esv2722910 CNV Deletion 23290073
esv3964 CNV Deletion 18987735
esv2722912 CNV Deletion 23290073
esv2722913 CNV Deletion 23290073

Variation tolerance for CHRNA4 Gene

Residual Variation Intolerance Score: 5.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRNA4 Gene

HapMap Linkage Disequilibrium report
CHRNA4
Human Gene Mutation Database (HGMD)
CHRNA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA4 Gene

Disorders for CHRNA4 Gene

MalaCards: The human disease database

(20) MalaCards diseases for CHRNA4 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epilepsy, nocturnal frontal lobe, 1
  • autosomal dominant nocturnal frontal lobe epilepsy
autosomal dominant nocturnal frontal lobe epilepsy
  • epilepsy, nocturnal frontal lobe, 1
nicotine dependence, protection against
  • nicotine dependence
chrna4-related nocturnal frontal lobe epilepsy, autosomal dominant
  • adnfle type 1
frontal lobe epilepsy
  • epilepsy frontal lobe
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ACHA4_HUMAN
  • Epilepsy, nocturnal frontal lobe, 1 (ENFL1) [MIM:600513]: An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. {ECO:0000269 PubMed:10563623, ECO:0000269 PubMed:14623738, ECO:0000269 PubMed:7550350}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CHRNA4

Genetic Association Database (GAD)
CHRNA4
Human Genome Epidemiology (HuGE) Navigator
CHRNA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRNA4
genes like me logo Genes that share disorders with CHRNA4: view

No data available for Genatlas for CHRNA4 Gene

Publications for CHRNA4 Gene

  1. Association of the neuronal nicotinic acetylcholine receptor subunit alpha4 polymorphisms with febrile convulsions. (PMID: 12887442) Chou I.C. … Tsai F.J. (Epilepsia 2003) 3 23 48 67
  2. Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. (PMID: 16636791) De Luca V. … Kennedy J.L. (Exp Brain Res 2006) 3 23 25
  3. Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. (PMID: 23641218) Hendrickson L.M. … Tapper A.R. (Front Psychiatry 2013) 25 26
  4. Neuropsychological function in patients with a single gene mutation associated with autosomal dominant nocturnal frontal lobe epilepsy. (PMID: 20189461) Wood A.G. … Reutens D.C. (Epilepsy Behav 2010) 3 23
  5. Epistasis between APOE and nicotinic receptor gene CHRNA4 in age related cognitive function and decline. (PMID: 20331911) Reinvang I. … Espeseth T. (J Int Neuropsychol Soc 2010) 3 23

Products for CHRNA4 Gene

Sources for CHRNA4 Gene

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