Aliases for CHRNA2 Gene
Aliases for CHRNA2 Gene
External Ids for CHRNA2 Gene
- HGNC: 1956
- Entrez Gene: 1135
- Ensembl: ENSG00000120903
- OMIM: 118502
- UniProtKB: Q15822
Previous GeneCards Identifiers for CHRNA2 Gene
- GC08M027100
- GC08M027823
- GC08M027340
- GC08M025862
- GC08M027317
Summaries for CHRNA2 Gene
-
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]
GeneCards Summary for CHRNA2 Gene
CHRNA2 (Cholinergic Receptor Nicotinic Alpha 2 Subunit) is a Protein Coding gene. Diseases associated with CHRNA2 include Epilepsy, Nocturnal Frontal Lobe, Type 4 and Chrna2-Related Nocturnal Frontal Lobe Epilepsy, Autosomal Dominant. Among its related pathways are Activation of Nicotinic Acetylcholine Receptors and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include drug binding. An important paralog of this gene is CHRNA4.
UniProtKB/Swiss-Prot for CHRNA2 Gene
-
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA2 Gene
Genomics for CHRNA2 Gene
Regulatory Elements for CHRNA2 Gene
Enhancers for CHRNA2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CHRNA2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CHRNA2 gene promoter:
Regulatory Element Products
Genomic Location for CHRNA2 Gene
- Chromosome:
- 8
- Start:
- 27,459,761 bp from pter
- End:
- 27,479,883 bp from pter
- Size:
- 20,123 bases
- Orientation:
- Minus strand
Genomic View for CHRNA2 Gene
Genes around CHRNA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.2 by Ensembl
- 8p21.2 by Entrez Gene
- 8p21.2 by HGNC
CHRNA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHRNA2 Gene
Proteins for CHRNA2 Gene
-
Protein details for CHRNA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15822-ACHA2_HUMAN
- Recommended name:
- Neuronal acetylcholine receptor subunit alpha-2
- Protein Accession:
- Q15822
- A8KAX3
- B4DK19
- J3KMY9
- Q9HAQ3
Protein attributes for CHRNA2 Gene
- Size:
- 529 amino acids
- Molecular mass:
- 59765 Da
- Quaternary structure:
-
- Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. The alpha-2:beta-2 nAChR complex is proposed to be a heteropentamer with two subtypes: LS (low agonist sensitivity) with a (alpha-2)3:(beta-2)2 and HS (high agonist sensitivity) with a (alpha-2)2:(beta-2)3 stoichiometry; the subtypes differ in their subunit binding interfaces which are involved in ligand binding.
Protein Expression for CHRNA2 Gene
Post-translational modifications for CHRNA2 Gene
Other Protein References for CHRNA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CHRNA2
- Novus Biologicals Antibodies for CHRNA2
- Invitrogen Antibodies for CHRNA2
- antibodies-online Antibodies for CHRNA2: See all 25
- GeneTex CHRNA2 antibody for CHRNA2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CHRNA2
Protein Products
-
OriGene Purified Proteins for CHRNA2
- Search Origene for MassSpec and Protein Over-expression Lysates for CHRNA2
- Origene Custom Protein Services for CHRNA2
- antibodies-online Proteins for CHRNA2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CHRNA2
Assay Products
- antibodies-online Kits for CHRNA2: See all 3
No data available for DME Specific Peptides for CHRNA2 Gene
Domains & Families for CHRNA2 Gene
Gene Families for CHRNA2 Gene
- HGNC:
- IUPHAR :
Protein Domains for CHRNA2 Gene
Suggested Antigen Peptide Sequences for CHRNA2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15822UniProtKB/Swiss-Prot:
ACHA2_HUMAN :- Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily.
- Family:
-
- Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily.
Function for CHRNA2 Gene
Molecular function for CHRNA2 Gene
- GENATLAS Biochemistry:
- cholinergic receptor,nicotinic,alpha 2 polypeptide,neuronal
- UniProtKB/Swiss-Prot Function:
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA | -- |
| GO:0008144 | drug binding | IEA | -- |
| GO:0015276 | ligand-gated ion channel activity | TAS | -- |
| GO:0015464 | acetylcholine receptor activity | IDA | 8906617 |
| GO:0022848 | acetylcholine-gated cation-selective channel activity | IDA | 8906617 |
Phenotypes for CHRNA2 Gene
- MGI mutant phenotypes for CHRNA2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CHRNA2:
Animal Model Products
-
Taconic Biosciences Mouse Models for CHRNA2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHRNA2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHRNA2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRNA2 gene
- Search ViGene Biosciences for CHRNA2
CRISPR Products
-
OriGene CRISPR knockouts for CHRNA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHRNA2
- GenScript: Design CRISPR guide RNA sequences for CHRNA2
miRNA for CHRNA2 Gene
- miRTarBase miRNAs that target CHRNA2
miRNA Products
- Search ViGene Biosciences for CHRNA2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHRNA2
- Browse OriGene Inhibitory RNA Products For CHRNA2
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRNA2 gene
Clone Products
-
OriGene ORF clones in human for CHRNA2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHRNA2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRNA2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CHRNA2 (Nicotinic Acetylcholine R alpha 2/CHRNA2)
Cell Line Products
-
Horizon Cell Lines for CHRNA2
-
ViGene Biosciences adenoviral particle packaged cDNA for CHRNA2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CHRNA2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRNA2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CHRNA2 Gene
Localization for CHRNA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHRNA2 Gene
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005892 | acetylcholine-gated channel complex | IDA | 8906617 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,NAS | 8906617 |
| GO:0030054 | cell junction | IEA | -- |
Pathways & Interactions for CHRNA2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of Nicotinic Acetylcholine Receptors | ||
| 2 | Transmission across Chemical Synapses |
.62
|
|
| 3 | Peptide ligand-binding receptors | ||
| 4 | Nanog in Mammalian ESC Pluripotency |
.48
|
|
| 5 | CREB Pathway | ||
Pathways by source for CHRNA2 Gene
9 Reactome pathways for CHRNA2 Gene
1 KEGG pathway for CHRNA2 Gene
2 Qiagen pathways for CHRNA2 Gene
Interacting Proteins for CHRNA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA,NAS | 8906617 |
| GO:0007165 | signal transduction | IDA | 8906617 |
| GO:0007271 | synaptic transmission, cholinergic | IBA | -- |
| GO:0007274 | neuromuscular synaptic transmission | IBA | -- |
No data available for SIGNOR curated interactions for CHRNA2 Gene
Drugs & Compounds for CHRNA2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Doxacurium chloride | Approved | Pharma | antagonist, Target | 0 | ||
| Mecamylamine | Approved | Pharma | Channel blocker, antagonist, Target, inhibitor | 25 | ||
| Biperiden | Approved | Pharma | antagonist, Target | Anticholinergic drug | 6 | |
| Carbachol | Approved | Pharma | Full agonist, Agonist, antagonist, Target, agonist | 3 | ||
| Cisatracurium Besylate | Approved | Pharma | antagonist, Target, inhibitor | Neuromuscular-blocking drug | 0 |
(1) ApexBio Compounds for CHRNA2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| SIB 1508Y maleate | 192231-16-6 |
Drug Products
- ApexBio compounds for CHRNA2
Transcripts for CHRNA2 Gene
mRNA/cDNA for CHRNA2 Gene
- (12) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHRNA2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHRNA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHRNA2
- GenScript: Design CRISPR guide RNA sequences for CHRNA2
miRNA Products
- Search ViGene Biosciences for CHRNA2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHRNA2
- Browse OriGene Inhibitory RNA Products For CHRNA2
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRNA2 gene
Clone Products
-
OriGene ORF clones in human for CHRNA2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHRNA2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRNA2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CHRNA2 (Nicotinic Acetylcholine R alpha 2/CHRNA2)
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for CHRNA2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for CHRNA2 Gene
This gene is overexpressed in Prostate (x24.7), Brain - Cortex (x5.3), and Brain - Frontal Cortex (BA9) (x4.8).
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRNA2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CHRNA2 Gene:
CHRNA2SOURCE GeneReport for Unigene cluster for CHRNA2 Gene:
Hs.57718Evidence on tissue expression from TISSUES for CHRNA2 Gene
- Nervous system(4.9)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRNA2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
Organs:
Head and neck:
- brain
- head
Primer Products
-
OriGene qPCR primer pairs for CHRNA2
No data available for mRNA Expression by UniProt/SwissProt for CHRNA2 Gene
Orthologs for CHRNA2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHRNA2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CHRNA2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CHRNA2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Chrna2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chrna2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CHRNA2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHRNA2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CHRNA2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | chrna2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | chrna2a 35 |
|
OneToMany | |
| chrna2b 35 |
|
OneToMany | |||
| chrna2 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | nAcRalpha-96Ab 36 34 |
|
||
| nAcRalpha-96Aa 36 |
|
|
|||
| nAcRalpha-7E 36 |
|
|
|||
| nAcRbgr-64B 36 |
|
|
|||
| nAcRbgr-96A 36 |
|
|
|||
| nAcRalpha-80B 36 |
|
|
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| nAcRalpha-30D 36 |
|
|
|||
| nAcRbgr-21C 36 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002972 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | unc-63 36 |
|
|
|
| acr-2 36 |
|
|
|||
| acr-12 36 |
|
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|||
| acr-3 36 |
|
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| unc-38 36 |
|
|
|||
| acr-16 36 |
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|||
| acr-8 36 |
|
|
|||
| lev-1 36 |
|
|
|||
| acr-10 36 |
|
|
|||
| acr-15 36 |
|
|
|||
| acr-7 36 |
|
|
|||
| unc-29 36 |
|
|
|||
| ZK973.5 36 |
|
|
|||
| acr-11 36 |
|
|
|||
| acr-17 36 |
|
|
|||
| acr-13 36 |
|
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|||
| acr-9 36 |
|
|
|||
| F18G5.4 36 |
|
|
|||
| Y73F8A.30 36 |
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| deg-3 36 |
|
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| acr-18 36 |
|
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| acr-22 36 |
|
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| acr-23 36 |
|
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| acr-5 36 |
|
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|||
| Y44A6E.1 36 |
|
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|||
| C04C3.2 36 |
|
|
|||
| F11C7.1 36 |
|
|
|||
| Y57G11C.2 36 |
|
|
- Species where no ortholog for CHRNA2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CHRNA2 Gene
Paralogs for CHRNA2 Gene
(19) SIMAP similar genes for CHRNA2 Gene using alignment to 7 proteins:
Variants for CHRNA2 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs104894063 | Pathogenic, Epilepsy, nocturnal frontal lobe, 4 (ENFL4) [MIM:610353] | 27,463,607(-) | GCTCA(A/T)CTCCT | reference, missense | |
| rs111565880 | Likely benign | 27,461,344(+) | CTCCT(C/G)CAGGA | utr-variant-3-prime | |
| rs12114756 | Likely benign | 27,471,103(+) | CTGTG(G/T)GTTGC | utr-variant-5-prime | |
| rs143223159 | Likely benign | 27,461,719(+) | CTGTC(A/G)ATGAC | reference, synonymous-codon | |
| rs146191907 | Likely benign | 27,459,756(+) | CACAG(C/T)TGAGT | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1020582 | CNV | gain | 25217958 |
| nsv831275 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
8.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.28;
25.58% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CHRNA2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA2 Gene
Disorders for CHRNA2 Gene
(8) MalaCards diseases for CHRNA2 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epilepsy, nocturnal frontal lobe, type 4 |
|
|
| chrna2-related nocturnal frontal lobe epilepsy, autosomal dominant |
|
|
| autosomal dominant nocturnal frontal lobe epilepsy |
|
|
| epilepsy, nocturnal frontal lobe, 1 |
|
|
| epilepsy |
|
Search CHRNA2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ACHA2_HUMAN- Epilepsy, nocturnal frontal lobe, 4 (ENFL4) [MIM:610353]: An autosomal dominant focal epilepsy characterized by nocturnal seizures associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking. {ECO:0000269 PubMed:16826524}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CHRNA2
No data available for Genatlas for CHRNA2 Gene
Publications for CHRNA2 Gene
- CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients. (PMID: 18226955) Combi R. … Tenchini M.L. (Sleep Med. 2009) 3 22 46 64
- A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy. (PMID: 19058950) Chen Y. … Xu Q. (Epilepsy Res. 2009) 3 22 46 64
- Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PMID: 17559419) Rigbi A. … Lerer B. (Genes Brain Behav. 2008) 3 22 46 64
- A major role of the nicotinic acetylcholine receptor gene CHRNA2 in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is unlikely. (PMID: 17602836) Gu W. … Steinlein O.K. (Neurosci. Lett. 2007) 3 22 46 64
- Increased sensitivity of the neuronal nicotinic receptor alpha2 subunit causes familial epilepsy with nocturnal wandering and ictal fear. (PMID: 16826524) Aridon P. … Casari G. (Am. J. Hum. Genet. 2006) 3 4 22 64
Products for CHRNA2 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for CHRNA2
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- Search Origene for MassSpec and Protein Over-expression Lysates for CHRNA2
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- OriGene qPCR primer pairs for CHRNA2
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- GenScript: Design CRISPR guide RNA sequences for CHRNA2
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- Novus Biologicals Antibodies for CHRNA2
- Novus Biologicals proteins and lysates for CHRNA2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for CHRNA2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CHRNA2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CHRNA2
- antibodies-online Antibodies for CHRNA2: See all 25
- antibodies-online Kits for CHRNA2: See all 3
- antibodies-online Proteins for CHRNA2: See all 3
- Search antibodies-online for peptides
- GeneTex CHRNA2 antibody for CHRNA2
- Search GeneTex for Proteins for CHRNA2
- ViGene Biosciences adenoviral particle packaged cDNA for CHRNA2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CHRNA2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CHRNA2 gene
- Search ViGene Biosciences for CHRNA2
- Santa Cruz Biotechnology (SCBT) Antibodies for CHRNA2
- Search Santa Cruz Biotechnology (SCBT) for CHRNA2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CHRNA2
- Horizon Cell Lines for CHRNA2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHRNA2
- VectorBuilder custom plasmid, inducible vectors for CHRNA2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRNA2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CHRNA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer