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Aliases for CHRNA10 Gene

Aliases for CHRNA10 Gene

  • Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal) 2 3
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 10 2
  • Nicotinic Acetylcholine Receptor Subunit Alpha-10 4
  • Acetylcholine Receptor 2
  • Alpha 10 (Neuronal) 2
  • NACHR Alpha-10 4
  • Nicotinic 2
  • NACHRA10 4

External Ids for CHRNA10 Gene

Previous GeneCards Identifiers for CHRNA10 Gene

  • GC11M004258
  • GC11M003952
  • GC11M003646
  • GC11M003651
  • GC11M003644
  • GC11M003645
  • GC11M003649
  • GC11M003654
  • GC11M003687
  • GC11M003420
  • GC11M003688
  • GC11M003691

Summaries for CHRNA10 Gene

GeneCards Summary for CHRNA10 Gene

CHRNA10 (Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal)) is a Protein Coding gene. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include receptor binding and acetylcholine-activated cation-selective channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for CHRNA10 Gene

  • Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Gene Wiki entry for CHRNA10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA10 Gene

Genomics for CHRNA10 Gene

Regulatory Elements for CHRNA10 Gene

Genomic Location for CHRNA10 Gene

Start:
3,665,587 bp from pter
End:
3,671,384 bp from pter
Size:
5,798 bases
Orientation:
Minus strand

Genomic View for CHRNA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRNA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA10 Gene

Proteins for CHRNA10 Gene

  • Protein details for CHRNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZZ6-ACH10_HUMAN
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-10
    Protein Accession:
    Q9GZZ6
    Secondary Accessions:

    Protein attributes for CHRNA10 Gene

    Size:
    450 amino acids
    Molecular mass:
    49705 Da
    Quaternary structure:
    • Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers
    Miscellaneous:
    • The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist)

neXtProt entry for CHRNA10 Gene

Proteomics data for CHRNA10 Gene at MOPED

Post-translational modifications for CHRNA10 Gene

  • Glycosylation at Asn40 and Asn56
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNA10 Gene

No data available for DME Specific Peptides for CHRNA10 Gene

Domains for CHRNA10 Gene

Gene Families for CHRNA10 Gene

HGNC:
  • CHR :Cholinergic receptors
  • CHRN :Ligand-gated ion channels / Acetylcholine receptors, nicotinic
IUPHAR :

Suggested Antigen Peptide Sequences for CHRNA10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZZ6

UniProtKB/Swiss-Prot:

ACH10_HUMAN :
  • Q9GZZ6
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
genes like me logo Genes that share domains with CHRNA10: view

Function for CHRNA10 Gene

Molecular function for CHRNA10 Gene

UniProtKB/Swiss-Prot Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Gene Ontology (GO) - Molecular Function for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004889 acetylcholine-activated cation-selective channel activity IEA --
GO:0005102 receptor binding TAS 11350119
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0005262 calcium channel activity IEA --
genes like me logo Genes that share ontologies with CHRNA10: view

Phenotypes for CHRNA10 Gene

genes like me logo Genes that share phenotypes with CHRNA10: view

Animal Models for CHRNA10 Gene

MGI Knock Outs for CHRNA10:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CHRNA10 Gene

Localization for CHRNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA10 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRNA10 Gene COMPARTMENTS Subcellular localization image for CHRNA10 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005892 acetylcholine-gated channel complex IEA --
GO:0016020 membrane TAS 11350119
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with CHRNA10: view

Pathways for CHRNA10 Gene

genes like me logo Genes that share pathways with CHRNA10: view

Pathways by source for CHRNA10 Gene

2 Qiagen pathways for CHRNA10 Gene
1 KEGG pathway for CHRNA10 Gene

Interacting Proteins for CHRNA10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000250699%0d%0a9606.ENSP00000384892%0d%0a9606.ENSP00000313490%0d%0a9606.ENSP00000325296%0d%0a
Selected Interacting proteins: ENSP00000250699 for CHRNA10 Gene via STRING

Gene Ontology (GO) - Biological Process for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0006812 cation transport --
GO:0007204 positive regulation of cytosolic calcium ion concentration IGI 18420419
GO:0007271 synaptic transmission, cholinergic TAS 11350119
genes like me logo Genes that share ontologies with CHRNA10: view

Compounds for CHRNA10 Gene

(1) HMDB Compounds for CHRNA10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(7) Drugbank Compounds for CHRNA10 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Chloroprocaine
  • Chloroprocain
133-16-4 target antagonist
Galantamine
  • (-)-Galanthamine
357-70-0 target allosteric modulator
Methadone
  • (+/-)-Methadone
76-99-3 target antagonist
Nicotine
  • L-Nicotine
54-11-5 target agonist
Pentolinium
  • Pentolinium tartrate
52-62-0 target antagonist

(6) IUPHAR Ligand for CHRNA10 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]methyllycaconitine None None 8.12
nicotine Activator Activation 4.7
alpha-conotoxin RgIA Antagonist Antagonist
alpha-bungarotoxin Antagonist Antagonist
strychnine Antagonist Antagonist
muscarine Antagonist Antagonist
genes like me logo Genes that share compounds with CHRNA10: view

Transcripts for CHRNA10 Gene

Unigene Clusters for CHRNA10 Gene

Cholinergic receptor, nicotinic, alpha 10 (neuronal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA10 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2:

Relevant External Links for CHRNA10 Gene

GeneLoc Exon Structure for
CHRNA10
ECgene alternative splicing isoforms for
CHRNA10

Expression for CHRNA10 Gene

mRNA expression in normal human tissues for CHRNA10 Gene

mRNA differential expression in normal tissues according to GTEx for CHRNA10 Gene

This gene is overexpressed in Muscle - Skeletal (18.1).

SOURCE GeneReport for Unigene cluster for CHRNA10 Gene Hs.732806

mRNA Expression by UniProt/SwissProt for CHRNA10 Gene

Q9GZZ6-ACH10_HUMAN
Tissue specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.
genes like me logo Genes that share expressions with CHRNA10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CHRNA10 Gene

Orthologs for CHRNA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRNA10 35
  • 99.33 (n)
  • 99.11 (a)
CHRNA10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHRNA10 35
  • 91.16 (n)
  • 94.64 (a)
CHRNA10 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRNA10 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrna10 35
  • 86.06 (n)
  • 91.95 (a)
Chrna10 16
Chrna10 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHRNA10 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHRNA10 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrna10 35
  • 85.16 (n)
  • 90.6 (a)
chicken
(Gallus gallus)
Aves CHRNA10 35
  • 71.04 (n)
  • 67.92 (a)
CHRNA10 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia chrna10 35
  • 64.95 (n)
  • 64.17 (a)
zebrafish
(Danio rerio)
Actinopterygii chrna10a 35
  • 61.04 (n)
  • 59.91 (a)
CR847523.1 36
  • 52 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta nAcRbeta-21C 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acr-21 35
  • 48.91 (n)
  • 44.24 (a)
lgc-5 36
  • 23 (a)
ManyToMany
deg-3 37
  • 33 (a)
acr-5 37
  • 30 (a)
C04C3.2 37
  • 28 (a)
acr-7 37
  • 38 (a)
Y73F8A.30 37
  • 30 (a)
acr-18 37
  • 28 (a)
F18G5.4 37
  • 35 (a)
acr-22 37
  • 31 (a)
acr-17 37
  • 30 (a)
Species with no ortholog for CHRNA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA10 Gene

ENSEMBL:
Gene Tree for CHRNA10 (if available)
TreeFam:
Gene Tree for CHRNA10 (if available)

Paralogs for CHRNA10 Gene

Paralogs for CHRNA10 Gene

genes like me logo Genes that share paralogs with CHRNA10: view

Variants for CHRNA10 Gene

Sequence variations from dbSNP and Humsavar for CHRNA10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_048172 -

Structural Variations from Database of Genomic Variants (DGV) for CHRNA10 Gene

Variant ID Type Subtype PubMed ID
dgv336e1 CNV Complex 17122850
nsv832051 CNV Gain 17160897
essv2992 CNV CNV 17122850
dgv337e1 CNV Complex 17122850
nsv428247 CNV Loss 18775914
nsv832052 CNV Loss 17160897
nsv526441 CNV Gain 19592680
nsv482156 CNV Loss 20164927

Relevant External Links for CHRNA10 Gene

HapMap Linkage Disequilibrium report
CHRNA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA10 Gene

Disorders for CHRNA10 Gene

(1) University of Copenhagen DISEASES for CHRNA10 Gene

Relevant External Links for CHRNA10

Genetic Association Database (GAD)
CHRNA10
Human Genome Epidemiology (HuGE) Navigator
CHRNA10
genes like me logo Genes that share disorders with CHRNA10: view

No data available for UniProtKB/Swiss-Prot for CHRNA10 Gene

Publications for CHRNA10 Gene

  1. Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). (PMID: 11350119) Lustig L.R. … Fuchs P.A. (Genomics 2001) 3 4 23
  2. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PMID: 17559419) Rigbi A. … Lerer B. (Genes Brain Behav. 2008) 3 23 48
  3. A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. (PMID: 11752216) Sgard F. … Besnard F. (Mol. Pharmacol. 2002) 3 4
  4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 48
  5. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. (PMID: 19259974) Saccone N.L. … Bierut L.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48

Products for CHRNA10 Gene

  • antibodies-online peptides for CHRNA10
  • antibodies-online antibodies for CHRNA10
  • antibodies-online kits for CHRNA10

Sources for CHRNA10 Gene

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