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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHRNA10 Gene

protein-coding   GIFtS: 54
GCID: GC11M003688

cholinergic receptor, nicotinic, alpha 10 (neuronal)

(Previous names: cholinergic receptor, nicotinic, alpha polypeptide 10 )
 Explore 3 diseases affiliated with
CHRNA10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CHRNA10    

Aliases
for CHRNA10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal)1 2     Acetylcholine Receptor, Nicotinic, Alpha 10 (Neuronal)2
Cholinergic Receptor, Nicotinic, Alpha Polypeptide 101 2     Neuronal Acetylcholine Receptor Subunit Alpha-102
Nicotinic Acetylcholine Receptor Subunit Alpha-102 3     NACHRA103
NACHR Alpha-102 3     

External Ids:    HGNC: 138001   Entrez Gene: 570532   Ensembl: ENSG000001297497   OMIM: 6063725   UniProtKB: Q9GZZ63   

Export aliases for CHRNA10 gene to outside databases

Previous GC identifers: GC11M004258 GC11M003952 GC11M003646 GC11M003651 GC11M003644 GC11M003645 GC11M003649 GC11M003654 GC11M003687 GC11M003420


Summaries
for CHRNA10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an
extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across
the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which
may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in
basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing.
This may protect against acoustic trauma

summary for CHRNA10:
Nicotinic receptors (nAChRs) are ligand-gated ion channels that modulate cell membrane potentials. Each
receptor is composed of pentameric combinations of subunits (alpha1-10, beta1-4, delta, epsilon and gamma).
Nicotinic receptors are generally divided into three functional classes: muscle subunits (alpha1, beta1,
delta, epsilon, gamma), standard neuronal subunits (alpha1-6 and beta2-4) that form in pairwise alphabeta
combinations, and subunits (alpha7-9) that can form homomeric nAChRs. Neuronal nicotinic receptors are found
in the central nervous system and in autonomic ganglia where they regulate processes such as transmitter
release, cell excitability and neuronal integration. Nicotinic receptors located at the neuromuscular
junctions of somatic muscles are responsible for muscular contraction.

Gene Wiki entry for CHRNA10


Genomic Views
for CHRNA10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHRNA10 gene promoter:
         p53   MIF-1   AP-4   FOXL1   HEN1   CP2   FOXJ2 (long isoform)   FOXJ2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHRNA10 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHRNA10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRNA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

CHRNA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRNA10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M003688:  view genomic region     (about GC identifiers)

Start:
 3,686,817 bp from pter      End:
 3,692,614 bp from pter
Size:
 5,798 bases      Orientation:
 minus strand

Proteins
for CHRNA10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6 (See protein sequence)
Recommended Name: Neuronal acetylcholine receptor subunit alpha-10 precursor  
Size: 450 amino acids; 49705 Da
Subunit: Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be
composed of CHRNA9-CHRNA10 heterooligomers
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable). Cell
membrane; Multi-pass membrane protein (Probable)
Miscellaneous: The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile,
binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic
acetylcholine receptor antagonist)

Explore the universe of human proteins at neXtProt for CHRNA10: NX_Q9GZZ6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9GZZ6

    • CHRNA10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065135.2  
    ENSEMBL proteins: 
     ENSP00000250699   ENSP00000437107   ENSP00000432757  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: CHRNA10
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    Novus Biologicals CHRNA10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS11350119
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030424axon IEA--


    CHRNA10 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CHRNA10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CHRNA10 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002394 Nicotinic_acetylcholine_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd
     IPR006029 Neurotrans-gated_channel_TM

    Graphical View of Domain Structure for InterPro Entry Q9GZZ6

    ProtoNet protein and cluster: Q9GZZ6

    2 Blocks protein families:
    IPB002394 Nicotinic acetylcholine receptor signature
    IPB006201 Neurotransmitter-gated ion-channel


    UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
    Alpha-10/CHRNA10 sub-subfamily


    Function
    for CHRNA10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
    Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an
    extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across
    the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which
    may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in
    basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing.
    This may protect against acoustic trauma

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CHRNA10
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHRNA10
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CHRNA10:
    hsa-miR-647 hsa-miR-875-3p hsa-miR-185 hsa-miR-4306 hsa-miR-4326 hsa-miR-3175 hsa-miR-1299 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CHRNA10 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHRNA10 (see all 7)
    OriGene shRNA RFP: CHRNA10
    OriGene siRNA: CHRNA10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRNA10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CHRNA10

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNA10 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNA10 

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    Search LifeMap BioReagents cell lines for CHRNA10

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0004889acetylcholine-activated cation-selective channel activity IEA--
    GO:0005102receptor binding TAS11350119
    GO:0005230extracellular ligand-gated ion channel activity ----
    GO:0005262calcium channel activity IEA--


    CHRNA10 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Chrna10tm1Jbou for CHRNA10
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Chrna10):
     hearing/vestibular/ear  nervous system 

    CHRNA10 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CHRNA10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Calcium channels
    		Calcium channels1.00
    2CREB Pathway
    		Intracellular Calcium Signaling0.50
    3Nanog in Mammalian ESC Pluripotency
    		eNOS Signaling0.48
    4Class A/1 (Rhodopsin-like receptors)
    		Neuroactive ligand-receptor interaction0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CHRNA10
        Calcium channels

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CHRNA10
        eNOS Signaling
    Intracellular Calcium Signaling


    1         Kegg Pathway  (Kegg details for CHRNA10):
        Neuroactive ligand-receptor interaction


    CHRNA10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHRNA10

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007204elevation of cytosolic calcium ion concentration IGI18420419
    GO:0007271synaptic transmission, cholinergic TAS11350119
    GO:0042127regulation of cell proliferation TAS11350119
    GO:0042472inner ear morphogenesis IEA--
    GO:0050910detection of mechanical stimulus involved in sensory perception of sound IEA--


    CHRNA10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CHRNA10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CHRNA10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Mecamylamine hydrochlorideNon-competitive nicotinic receptor antagonist[826-39-1]
    (±)-EpibatidineVery potent nicotinic agonist[140111-52-0]
    ACV 1alpha9alpha10-selective antagonist[740980-24-9]
    (±)-Anatoxin A fumarateNicotinic agonist[64285-06-9]

    1 HMDB Compound for CHRNA10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 DrugBank Compounds for CHRNA10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Galantamine(-)-Galanthamine (see all 3)357-70-0targetallosteric modulator12137632 11129124 12481195 20480924 12177686 10971048
    NicotineL-Nicotine (see all 2)54-11-5targetagonist19560048 20081230 20400469 11006350
    PentoliniumPentolinium tartrate (see all 3)52-62-0targetantagonist17139284 8516349 17016423 7761270
    TrimethaphanThimethaphan (see all 3)7187-66-8targetantagonist8232788 17139284 17016423 7963258
    ChloroprocaineChloroprocain (see all 3)133-16-4targetantagonist17139284 17016423
    Methadone(+/-)-Methadone (see all 8)76-99-3targetantagonist17139284 17016423
    SuccinylcholineScoline (see all 3)306-40-1targetagonist16571968

    Search CenterWatch for drugs/clinical trials and news about CHRNA10 / ACH10 

    Transcripts
    for CHRNA10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CHRNA10 gene: 
    NM_020402.2  

    Unigene Cluster for CHRNA10:

    Cholinergic receptor, nicotinic, alpha 10 (neuronal)
    Hs.732806  [show with all ESTs]
    Unigene Representative Sequence: NM_020402
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250699(uc001lyf.3 uc010qxt.2 uc010qxu.2) ENST00000534359
    ENST00000526599 ENST00000493827

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CHRNA10
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHRNA10
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CHRNA10:
    hsa-miR-647 hsa-miR-875-3p hsa-miR-185 hsa-miR-4306 hsa-miR-4326 hsa-miR-3175 hsa-miR-1299 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CHRNA10 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHRNA10 (see all 7)
    OriGene shRNA RFP: CHRNA10
    OriGene siRNA: CHRNA10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRNA10
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNA10 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRNA10
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    GenScript: all cDNA clones in your preferred vector: CHRNA10 (NM_020402)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNA10 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRNA10
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHRNA10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRNA10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNA10

    Additional cDNA sequence: 

    AF199235.2 AJ278118.1 AJ295237.1 BC033833.1 BC136250.1 BC143303.1 

    4 DOTS entries:

    DT.434596  DT.92418565  DT.409305  DT.75100915 

    24/38 AceView cDNA sequences (see all 38):

    AI146549 AW135678 AI673104 BQ010406 AJ295237 BF516446 AI939323 AW207378 
    AA491394 BX096928 AI139700 BM665196 BF345692 NM_020402 AF199235 BM702479 
    AA262389 BC033833 BF059093 BF057531 AI660069 BE855541 BF343450 BF516351 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA10    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
    SP1:                    -           -               
    SP2:                                                


    ECgene alternative splicing isoforms for CHRNA10

    Expression
    for CHRNA10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHRNA10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CHRNA10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHRNA10

    SOURCE GeneReport for Unigene cluster: Hs.732806

    UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
    Tissue specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood
    lymphocytes

        SABiosciences Custom PCR Arrays for CHRNA10
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRNA10
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA10

    Orthologs
    for CHRNA10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CHRNA10 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CHRNA101 cholinergic receptor, nicotinic, alpha 10 70.15(n)
    67.05(a)    		   430628  NM_001101036.1  NP_001094506.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CHRNA106
    --
    (see all 3)    		 --
    		 59(a)
    33(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 GL344444.1(2597-11603)
    GL344222.1(30621-54685)
    zebrafish
    (Danio rerio)    		 Actinopterygii chrna101 cholinergic receptor, nicotinic, alpha 10 60.74(n)
    59.56(a)    		   556507  NM_001044804.1  NP_001038269.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta nAcRbeta-21C6
    		 nicotinic acetylcholine receptor beta 21C
    		 22(a)
    		 1 ↔ 1
    		 2L(545129-547096)
    worm
    (Caenorhabditis elegans)    		 Secernentea acr-73 Acetylcholine receptor 38(a)
    (best of 9)    		   II(7845587-7849647)   --


    ENSEMBL Gene Tree for CHRNA10 (if available)
    TreeFam Gene Tree for CHRNA10 (if available) 

    Paralogs
    for CHRNA10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHRNA10 gene
    CHRNA52  CHRNA22  CHRNA12  CHRNA62  CHRNA72  CHRNE2  CHRNB42  CHRNA42  
    CHRNA92  CHRNB22  CHRNG2  CHRNA32  CHRFAM7A2  CHRNB12  CHRNB32  CHRND2  
    18/19 SIMAP similar genes for CHRNA10 using alignment to 4 protein entries:     ACH10_HUMAN (see all proteins) (see all similar genes):
    CHRNA9    CHRNA7-2    CHRNA5    HTR3B    CHRNA1    CHRNB4
    CHRNA4    CHRNB3    HTR3A    CHRNE    CHRNA3    CHRNA6
    CHRNA7    CHRNG    CHRNB2    CHRNA2    CHRNB1    CHRFAM7A

    CHRNA10 for paralogs           About GeneDecksing



    Genomic Variants
    for CHRNA10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/196 NCBI SNPs in CHRNA10 are shown (see all 196)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1417311461,2
    		--3686393(+) TTTTTG/TTTAAG 1 -- int10--------
    rs1900259811,2
    		--3686415(+) TAGCAG/TTGGGG 1 -- int10--------
    rs785582391,2
    		F,--3686429(+) TATATA/GCCAAC 1 -- int12Minor allele frequency- G:0.09WA EA 238
    rs122230501,2
    		--3686640(+) gcaaaT/Gtcaca 1 -- int13Minor allele frequency- G:0.19CSA WA EA 240
    rs560845601,2
    		C,F,--3686727(-) GCTGGC/TGCAAG 1 -- int12Minor allele frequency- T:0.10EU NA 468
    rs1462786461,2
    		--3686778(+) TCCACC/TACCAC 1 -- int10--------
    rs1393841001,2
    		--3686801(+) TAACAA/CAGGGC 1 -- int10--------
    rs122699601,2
    		C,F,--3686809(+) GGCATC/TGAGGA 1 -- int12Minor allele frequency- T:0.06EU NA 492
    rs122215251,2
    		C,F,A,H,--3686944(+) GGTAAC/GAGCCA 1 -- ut31 ese321Minor allele frequency- G:0.11NS EA NA EU CSA WA 2732
    rs765877101,2
    		C,F,--3686957(+) GCCCTG/ACAAAG 1 -- ut311Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CHRNA10 (3686817 - 3692614 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CHRNA10
         1 CNV: 3833

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    Disorders / Diseases
    for CHRNA10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CHRNA10 for disorders           About GeneDecksing

    OMIM gene information: 606372    OMIM disorders: --

    3 diseases for CHRNA10:    About MalaCards
    neuronitis    tonsillitis    conjunctivitis

    1 disease from the University of Copenhagen DISEASES database for CHRNA10:
    Nicotine dependence
    Human Genome Epidemiology (HuGE) Navigator: CHRNA10 (10 documents)

    Export disorders for CHRNA10 gene to outside databases

    Publications
    for CHRNA10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHRNA10 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with CHRNA10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). (PubMed id 11350119)1, 2, 9 Lustig L.R.... Fuchs P.A. (2001)
    2. Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. (PubMed id 15531379)1, 2 Peng H....Lustig L.R. (2004)
    3. A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. (PubMed id 11752216)1, 2 Sgard F.... Besnard F. (2002)
    4. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PubMed id 17559419)1, 9 Rigbi A....Lerer B. (2008)
    5. Molecular basis for the differential sensitivity of ra t and human a9a10 nAChRs to a-conotoxin RgIA. (PubMed id 22774872)1 Azam L. and McIntosh J.M. (2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Role of alpha5 nicotinic acetylcholine receptors in p harmacological and behavioral effects of nicotine in mice. (PubMed id 20400469)7 Jackson K.J....Damaj M.I. (2010)
    8. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (PubMed id 20584212)1 Saccone N.L....Bierut L.J. (2010)
    9. Why do young women smoke? VI. A controlled study of n icotine effects on attention: pharmacogenetic interactions. (PubMed id 20231857)1 Rigbi A....Lerer B. (2010)
    10. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1 He C....Hunter D.J. (2010)

    External Searches for CHRNA10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CHRNA10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57053 HGNC: 13800 AceView: CHRNA10 Ensembl:ENSG00000129749 euGenes: HUgn57053
    ECgene: CHRNA10 Kegg: 57053 H-InvDB: CHRNA10

    Other Databases showing CHRNA10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CHRNA10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHRNA10 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CHRNA10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CHRNA10 gene:
    Search GeneIP for patents involving CHRNA10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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