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CHRNA10 Gene

protein-coding   GIFtS: 54
GCID: GC11M003699

Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal)

(Previous names: cholinergic receptor, nicotinic, alpha polypeptide 10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal)1 2     Alpha 10 (Neuronal)1
Cholinergic Receptor, Nicotinic, Alpha Polypeptide 101 2     nicotinic1
Nicotinic Acetylcholine Receptor Subunit Alpha-102 3     Acetylcholine Receptor, Nicotinic, Alpha 10 (Neuronal)2
NACHR Alpha-102 3     Neuronal Acetylcholine Receptor Subunit Alpha-102
Acetylcholine Receptor1     NACHRA103

External Ids:    HGNC: 138001   Entrez Gene: 570532   Ensembl: ENSG000001297497   OMIM: 6063725   UniProtKB: Q9GZZ63   

Export aliases for CHRNA10 gene to outside databases

Previous GC identifers: GC11M004258 GC11M003952 GC11M003646 GC11M003651 GC11M003644 GC11M003645 GC11M003649 GC11M003654 GC11M003687 GC11M003420 GC11M003688 GC11M003691


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CHRNA10 Gene:
CHRNA10 (cholinergic receptor, nicotinic, alpha 10 (neuronal)) is a protein-coding gene. Diseases associated with CHRNA10 include nicotine dependence, and nicotine addiction. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and receptor binding. An important paralog of this gene is HTR3E.

UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may
induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting
channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium,
the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may
lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the
range of dynamic hearing. This may protect against acoustic trauma

Gene Wiki entry for CHRNA10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CHRNA10 gene promoter:
         p53   MIF-1   AP-4   FOXL1   HEN1   CP2   FOXJ2 (long isoform)   FOXJ2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRNA10 promoter sequence
   Search Chromatin IP Primers for CHRNA10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRNA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

CHRNA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRNA10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M003699:  view genomic region     (about GC identifiers)

Start:
3,686,817 bp from pter      End:
3,692,614 bp from pter
Size:
5,798 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6 (See protein sequence)
Recommended Name: Neuronal acetylcholine receptor subunit alpha-10 precursor  
Size: 450 amino acids; 49705 Da
Subunit: Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be
composed of CHRNA9-CHRNA10 heterooligomers
Miscellaneous: The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological
profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine
(a muscarinic acetylcholine receptor antagonist)

Explore the universe of human proteins at neXtProt for CHRNA10: NX_Q9GZZ6

Explore proteomics data for CHRNA10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn40, Asn56

  • See CHRNA10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065135.2  
    ENSEMBL proteins: 
     ENSP00000250699   ENSP00000437107   ENSP00000432757  

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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHRN: Ligand-gated ion channels / Acetylcholine receptors, nicotinic
    CHR: Cholinergic receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha10
    Nicotinic acetylcholine receptors

    Selected InterPro protein domains (see all 6):
     IPR027361 Acetylcholine_rcpt_TM
     IPR002394 Nicotinic_acetylcholine_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry Q9GZZ6

    ProtoNet protein and cluster: Q9GZZ6

    2 Blocks protein domains:
    IPB002394 Nicotinic acetylcholine receptor signature
    IPB006201 Neurotransmitter-gated ion-channel


    UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1)
    subfamily. Alpha-10/CHRNA10 sub-subfamily


    CHRNA10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACH10_HUMAN, Q9GZZ6
    Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may
    induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting
    channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium,
    the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may
    lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the
    range of dynamic hearing. This may protect against acoustic trauma

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004889acetylcholine-activated cation-selective channel activity IEA--
    GO:0005102receptor binding TAS11350119
    GO:0005230extracellular ligand-gated ion channel activity ----
    GO:0005262calcium channel activity IEA--
         
    CHRNA10 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chrna10):
     hearing/vestibular/ear  nervous system 

    CHRNA10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Chrna10tm1Jbou for CHRNA10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHRNA10
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHRNA10

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate CHRNA10:
    hsa-miR-647 hsa-miR-875-3p hsa-miR-185 hsa-miR-4306 hsa-miR-4326 hsa-miR-3175 hsa-miR-1299 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCHRNA10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CHRNA10

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    GenScript: all cDNA clones in your preferred vector: CHRNA10 (NM_020402)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACH10_HUMAN, Q9GZZ6: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable).
    Cell membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane TAS11350119
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030424axon IEA--
    GO:0043204perikaryon IEA--

    CHRNA10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHRNA10 About    
    See pathways by source

    SuperPathContained pathways About
    1CREB Pathway
    Intracellular Calcium Signaling0.50
    2Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    3Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    4Calcium channels
    Calcium channels

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CHRNA10
        eNOS Signaling
    Intracellular Calcium Signaling


    1 Kegg Pathway  (Kegg details for CHRNA10):
        Neuroactive ligand-receptor interaction


    CHRNA10 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHRNA10
    Interactions:

        Search GeneGlobe Interaction Network for CHRNA10

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport ----
    GO:0007204positive regulation of cytosolic calcium ion concentration IGI18420419
    GO:0007271synaptic transmission, cholinergic TAS11350119
    GO:0042127regulation of cell proliferation TAS11350119

    CHRNA10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHRNA10 (ACH10)

    1 HMDB Compound for CHRNA10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 DrugBank Compounds for CHRNA10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Galantamine(-)-Galanthamine (see all 3)357-70-0targetallosteric modulator12137632 11129124 12481195 20480924 12177686 10971048
    NicotineL-Nicotine (see all 2)54-11-5targetagonist19560048 20081230 20400469 11006350
    PentoliniumPentolinium tartrate (see all 3)52-62-0targetantagonist17139284 8516349 17016423 7761270
    TrimethaphanThimethaphan (see all 3)7187-66-8targetantagonist8232788 17139284 17016423 7963258
    ChloroprocaineChloroprocain (see all 3)133-16-4targetantagonist17139284 17016423
    Methadone(+/-)-Methadone (see all 8)76-99-3targetantagonist17139284 17016423
    SuccinylcholineScoline (see all 3)306-40-1targetagonist16571968

    6 IUPHAR Ligands for CHRNA10 (alpha10)    About this table
    LigandTypeActionAffinityPubmed IDs
    alpha-conotoxin RgIA
    AntagonistAntagonist--
    nicotine
    AntagonistAntagonist--
    [3H]methyllycaconitine
    NoneNone--
    alpha-bungarotoxin
    AntagonistAntagonist--
    strychnine
    AntagonistAntagonist--
    muscarine
    AntagonistAntagonist--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHRNA10 gene: 
    NM_020402.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250699(uc001lyf.3 uc010qxt.2 uc010qxu.2) ENST00000534359
    ENST00000526599 ENST00000493827
    miRNA
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    Block miRNA regulation of human, mouse, rat CHRNA10 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CHRNA10:
    hsa-miR-647 hsa-miR-875-3p hsa-miR-185 hsa-miR-4306 hsa-miR-4326 hsa-miR-3175 hsa-miR-1299 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCHRNA10 3' UTR sequence
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CHRNA10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHRNA10
      QuantiTect SYBR Green Assays in human, mouse, rat CHRNA10
      QuantiFast Probe-based Assays in human, mouse, rat CHRNA10

    Selected AceView cDNA sequences (see all 38):

    AI146549 AI139700 AW207378 BQ010406 AA491394 BF516446 BX096928 BM665196 
    AI673104 AW135678 AJ295237 AI939323 BM702479 BF516351 BF059093 BF343450 
    BF345692 BC033833 AJ278118 BF057531 BE855541 AA262389 AF199235 AI660069 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA10    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
    SP1:                    -           -               
    SP2:                                                


    ECgene alternative splicing isoforms for CHRNA10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHRNA10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHRNA10 Expression
    About this image

    CHRNA10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHRNA10 Protein Expression

    UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
    Tissue specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral
    blood lymphocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHRNA10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrna101 , 5 cholinergic receptor, nicotinic, alpha polypeptide 10 less1, 5 86.06(n)1
    91.95(a)1
      7 (54.71 cM)5
    5041861  NM_001081424.11  NP_001074893.11 
     1021112665 
    chicken
    (Gallus gallus)
    Aves CHRNA101 cholinergic receptor, nicotinic, alpha 10 71.04(n)
    67.92(a)
      430628  NM_001101036.1  NP_001094506.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    62(a)
    many ↔ many
    GL344444.1(2587-11603)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia chrna101 cholinergic receptor, nicotinic, alpha 10 (neuronal) less 64.95(n)
    64.17(a)
      100487976  XM_002942872.2  XP_002942918.2 
    zebrafish
    (Danio rerio)
    Actinopterygii chrna10a1 cholinergic receptor, nicotinic, alpha 10a 61.04(n)
    59.91(a)
      556507  NM_001044804.1  NP_001038269.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nAcRbeta-21C6
    nicotinic acetylcholine receptor beta 21C
    25(a)
    many ↔ many
    2L(545129-547096)
    worm
    (Caenorhabditis elegans)
    Secernentea acr-73
    acr-211
    Acetylcholine receptor3
    acr-211
    38(a)
    (best of 9)3
    48.91(n)1
    44.24(a)1
      II(7845587-7849647)3
    1850041  NM_066051.31  NP_498452.31 


    ENSEMBL Gene Tree for CHRNA10 (if available)
    TreeFam Gene Tree for CHRNA10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHRNA10 gene
    HTR3E2  HTR3A2  CHRNA92  HTR3B2  ZACN2  CHRNA72  CHRFAM7A2  HTR3C2  
    HTR3D2  
    Selected SIMAP similar genes for CHRNA10 using alignment to 4 protein entries:     ACH10_HUMAN (see all proteins) (see all similar genes):
    CHRNA9    CHRNA7-2    CHRNA5    HTR3B    CHRNA1    CHRNB4
    CHRNA4    CHRNB3    HTR3A    CHRNE    CHRNA3    CHRNA6
    CHRNA7    CHRNG    CHRNB2    CHRNA2    CHRNB1    CHRFAM7A

    CHRNA10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHRNA10 (see all 253)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417311461,2
    --3686393(+) TTTTTG/TTTAAG 1 -- int10--------
    rs1900259811,2
    --3686415(+) TAGCAG/TTGGGG 1 -- int10--------
    rs785582391,2
    C,F--3686429(+) TATATA/GCCAAC 1 -- int12Minor allele frequency- G:0.09WA EA 238
    rs122230501,2
    C,F--3686640(+) gcaaaT/Gtcaca 1 -- int13Minor allele frequency- G:0.19CSA WA EA 240
    rs560845601,2
    C,F--3686727(-) GCTGGC/TGCAAG 1 -- int12Minor allele frequency- T:0.10EU NA 468
    rs1462786461,2
    --3686778(+) TCCACC/TACCAC 1 -- int10--------
    rs1393841001,2
    --3686801(+) TAACAA/CAGGGC 1 -- int10--------
    rs122699601,2
    C,F--3686809(+) GGCATC/TGAGGA 1 -- int12Minor allele frequency- T:0.06EU NA 492
    rs556931851,2
    C,F--3686859(-) CATTTG/CGCCCC 1 -- ut312Minor allele frequency- C:0.02EU WA 500
    rs122215251,2
    C,F,A,H--3686944(+) GGTAAC/GAGCCA 1 -- ut31 ese321Minor allele frequency- G:0.11NS EA NA EU CSA WA 2732

    HapMap Linkage Disequilibrium report for CHRNA10 (3686817 - 3692614 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CHRNA10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428247CNV Loss18775914
    nsv482156CNV Loss20164927
    nsv832052CNV Loss17160897
    nsv526441CNV Gain19592680
    nsv832051CNV Gain17160897
    essv2992CNV CNV17122850
    dgv337e1CNV Complex17122850
    dgv336e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606372    OMIM disorders: --

    6 diseases for CHRNA10:    
    About MalaCards
    nicotine dependence    nicotine addiction    tonsillitis    conjunctivitis
    neuronitis    bipolar disorder

    1 disease from the University of Copenhagen DISEASES database for CHRNA10:
    Nicotine dependence

    CHRNA10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHRNA10
    Human Genome Epidemiology (HuGE) Navigator: CHRNA10 (10 documents)

    Export disorders for CHRNA10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHRNA10 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with CHRNA10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). (PubMed id 11350119)1, 2, 9 Lustig L.R.... Fuchs P.A. (Genomics 2001)
    2. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PubMed id 17559419)1, 4, 9 Rigbi A....Lerer B. (Genes Brain Behav. 2008)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (PubMed id 20584212)1, 4 Saccone N.L....Bierut L.J. (Genes Brain Behav. 2010)
    6. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. (PubMed id 19259974)1, 4 Saccone N.L....Bierut L.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    8. No evidence for association between 19 cholinergic genes and bipolar disorder. (PubMed id 17373692)1, 4 Shi J....Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    9. Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. (PubMed id 15531379)1, 2 Peng H....Lustig L.R. (Life Sci. 2004)
    10. A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. (PubMed id 11752216)1, 2 Sgard F.... Besnard F. (Mol. Pharmacol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57053 HGNC: 13800 AceView: CHRNA10 Ensembl:ENSG00000129749 euGenes: HUgn57053
    ECgene: CHRNA10 Kegg: 57053 H-InvDB: CHRNA10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CHRNA10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CHRNA10 gene:
    Search GeneIP for patents involving CHRNA10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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