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Aliases for CHRNA10 Gene

Aliases for CHRNA10 Gene

  • Cholinergic Receptor Nicotinic Alpha 10 Subunit 2 3 5
  • Acetylcholine Receptor, Nicotinic, Alpha 10 (Neuronal) 2
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 10 2
  • Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal) 2
  • Nicotinic Acetylcholine Receptor Subunit Alpha-10 4
  • Cholinergic Receptor, Nicotinic Alpha 10 2
  • NACHR Alpha-10 4
  • NACHRA10 4

External Ids for CHRNA10 Gene

Previous GeneCards Identifiers for CHRNA10 Gene

  • GC11M004258
  • GC11M003952
  • GC11M003646
  • GC11M003651
  • GC11M003644
  • GC11M003645
  • GC11M003649
  • GC11M003654
  • GC11M003687
  • GC11M003420
  • GC11M003688
  • GC11M003691

Summaries for CHRNA10 Gene

GeneCards Summary for CHRNA10 Gene

CHRNA10 (Cholinergic Receptor Nicotinic Alpha 10 Subunit) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and CREB Pathway. GO annotations related to this gene include receptor binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is CHRNA9.

UniProtKB/Swiss-Prot for CHRNA10 Gene

  • Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Gene Wiki entry for CHRNA10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA10 Gene

Genomics for CHRNA10 Gene

Regulatory Elements for CHRNA10 Gene

Enhancers for CHRNA10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G003830 1.8 FANTOM5 ENCODE dbSUPER 9.6 -163.1 -163101 12.5 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D RHOG NUP98 RRM1 ENSG00000206976 ART1 ART5 CHRNA10 STIM1 ENSG00000230593 ENSG00000236710
GH11G003824 1.2 ENCODE dbSUPER 9.6 -152.9 -152948 3.2 HDGF HNRNPUL1 ATF1 CREB3L1 ARNT AGO1 ARID4B ZNF766 CBX5 GATA2 NUP98 ART1 ART5 CHRNA10 GC11P003826 GC11P003814
GH11G003721 0.9 Ensembl ENCODE 10.6 -49.6 -49637 2.5 PAF1 SIX4 JUN BHLHE40 MAX SIN3A DPF2 JUND CTBP1 FOS NUP98 RNU7-50P CHRNA10 ART5 RNU6-1143P GC11P003749
GH11G003709 0.5 ENCODE 11.1 -37.2 -37157 1.7 JUND HNF4G KDM1A HNF4A CHRNA10 NUP98 ART5 RNU6-1143P GC11P003701
GH11G003812 0.5 FANTOM5 10 -139.0 -138960 0.1 TCF12 NCOR1 NR2F6 RBFOX2 RHOG RNU7-50P STIM1 ENSG00000206976 CHRNA10 NUP98 PGAP2 RRM1 GC11P003814
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHRNA10 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHRNA10 Gene

Chromosome:
11
Start:
3,665,587 bp from pter
End:
3,673,208 bp from pter
Size:
7,622 bases
Orientation:
Minus strand

Genomic View for CHRNA10 Gene

Genes around CHRNA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRNA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRNA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA10 Gene

Proteins for CHRNA10 Gene

  • Protein details for CHRNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZZ6-ACH10_HUMAN
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-10
    Protein Accession:
    Q9GZZ6

    Protein attributes for CHRNA10 Gene

    Size:
    450 amino acids
    Molecular mass:
    49705 Da
    Quaternary structure:
    • Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. Interacts with the conotoxin GeXXA (PubMed:26395518). Interacts with the alpha-conotoxin RgIA (By similarity).
    Miscellaneous:
    • The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

neXtProt entry for CHRNA10 Gene

Post-translational modifications for CHRNA10 Gene

  • Glycosylation at posLast=4040 and Asn56
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNA10 Gene

No data available for DME Specific Peptides for CHRNA10 Gene

Domains & Families for CHRNA10 Gene

Gene Families for CHRNA10 Gene

Suggested Antigen Peptide Sequences for CHRNA10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZZ6

UniProtKB/Swiss-Prot:

ACH10_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
genes like me logo Genes that share domains with CHRNA10: view

Function for CHRNA10 Gene

Molecular function for CHRNA10 Gene

UniProtKB/Swiss-Prot Function:
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Gene Ontology (GO) - Molecular Function for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 11350119
GO:0005216 ion channel activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005262 calcium channel activity IEA --
GO:0022848 acetylcholine-gated cation-selective channel activity IEA --
genes like me logo Genes that share ontologies with CHRNA10: view
genes like me logo Genes that share phenotypes with CHRNA10: view

Animal Models for CHRNA10 Gene

MGI Knock Outs for CHRNA10:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHRNA10

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for CHRNA10 (Nicotinic Acetylcholine R alpha 10/CHRNA10)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHRNA10 Gene

Localization for CHRNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA10 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHRNA10 gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005892 acetylcholine-gated channel complex IEA --
GO:0016020 membrane TAS,IEA 11350119
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CHRNA10: view

Pathways & Interactions for CHRNA10 Gene

genes like me logo Genes that share pathways with CHRNA10: view

Pathways by source for CHRNA10 Gene

1 KEGG pathway for CHRNA10 Gene
2 Qiagen pathways for CHRNA10 Gene

Gene Ontology (GO) - Biological Process for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IGI 18420419
GO:0007271 synaptic transmission, cholinergic TAS 11350119
genes like me logo Genes that share ontologies with CHRNA10: view

No data available for SIGNOR curated interactions for CHRNA10 Gene

Drugs & Compounds for CHRNA10 Gene

(19) Drugs for CHRNA10 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotine Approved Pharma Antagonist, antagonist, Target, agonist 1103
Pentolinium Approved Pharma antagonist, Target 0
Trimethaphan Approved Pharma antagonist, Target 10
Chloroprocaine Approved Pharma Target, antagonist 19
Ethanol Approved Pharma Target 2137

(2) Additional Compounds for CHRNA10 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-Bungarotoxin
Antagonist 11032-79-4
alpha-conotoxin RgIA
Antagonist

(2) ApexBio Compounds for CHRNA10 Gene

Compound Action Cas Number
ACV 1 740980-24-9
α-Conotoxin ImI 156467-85-5
genes like me logo Genes that share compounds with CHRNA10: view

Drug Products

Transcripts for CHRNA10 Gene

Unigene Clusters for CHRNA10 Gene

Cholinergic receptor, nicotinic, alpha 10 (neuronal):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for CHRNA10 (Nicotinic Acetylcholine R alpha 10/CHRNA10)

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA10 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2:

Relevant External Links for CHRNA10 Gene

GeneLoc Exon Structure for
CHRNA10
ECgene alternative splicing isoforms for
CHRNA10

Expression for CHRNA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHRNA10 Gene

mRNA differential expression in normal tissues according to GTEx for CHRNA10 Gene

This gene is overexpressed in Muscle - Skeletal (x18.1).

NURSA nuclear receptor signaling pathways regulating expression of CHRNA10 Gene:

CHRNA10

SOURCE GeneReport for Unigene cluster for CHRNA10 Gene:

Hs.732806

mRNA Expression by UniProt/SwissProt for CHRNA10 Gene:

Q9GZZ6-ACH10_HUMAN
Tissue specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for CHRNA10 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with CHRNA10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRNA10 Gene

Orthologs for CHRNA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRNA10 34 35
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia CHRNA10 34 35
  • 91.16 (n)
mouse
(Mus musculus)
Mammalia Chrna10 16 35 34
  • 86.06 (n)
rat
(Rattus norvegicus)
Mammalia Chrna10 34
  • 85.16 (n)
oppossum
(Monodelphis domestica)
Mammalia CHRNA10 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHRNA10 35
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRNA10 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHRNA10 34 35
  • 71.04 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia chrna10 34
  • 64.95 (n)
zebrafish
(Danio rerio)
Actinopterygii chrna10a 34
  • 61.04 (n)
CR847523.1 35
  • 52 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta nAcRbeta-21C 35
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acr-21 34
  • 48.91 (n)
acr-7 36
  • 38 (a)
F18G5.4 36
  • 35 (a)
deg-3 36
  • 33 (a)
acr-22 36
  • 31 (a)
Y73F8A.30 36
  • 30 (a)
acr-5 36
  • 30 (a)
acr-17 36
  • 30 (a)
C04C3.2 36
  • 28 (a)
acr-18 36
  • 28 (a)
lgc-5 35
  • 23 (a)
ManyToMany
Species where no ortholog for CHRNA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA10 Gene

ENSEMBL:
Gene Tree for CHRNA10 (if available)
TreeFam:
Gene Tree for CHRNA10 (if available)

Paralogs for CHRNA10 Gene

Paralogs for CHRNA10 Gene

genes like me logo Genes that share paralogs with CHRNA10: view

Variants for CHRNA10 Gene

Sequence variations from dbSNP and Humsavar for CHRNA10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000262127 -- 3,667,972(+) CCCTT(A/C)CTTGC intron-variant
rs1001105716 -- 3,671,999(+) AGCTC(A/C)GGCCC upstream-variant-2KB, utr-variant-5-prime
rs1001123470 -- 3,672,868(+) GAAAT(C/T)CAACA upstream-variant-2KB, utr-variant-5-prime
rs1001562591 -- 3,673,120(+) CAGGC(A/G)TGAGC upstream-variant-2KB, utr-variant-5-prime
rs1001801412 -- 3,671,257(+) CTGCA(A/G)GGAGT reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CHRNA10 Gene

Variant ID Type Subtype PubMed ID
esv2759796 CNV gain+loss 17122850
esv3625147 CNV gain 21293372
esv3625148 CNV gain 21293372
nsv1046356 CNV gain 25217958
nsv428247 CNV loss 18775914
nsv482156 CNV loss 20164927
nsv526441 CNV gain 19592680
nsv832051 CNV gain 17160897
nsv832052 CNV loss 17160897

Variation tolerance for CHRNA10 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRNA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHRNA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA10 Gene

Disorders for CHRNA10 Gene

Relevant External Links for CHRNA10

Genetic Association Database (GAD)
CHRNA10
Human Genome Epidemiology (HuGE) Navigator
CHRNA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRNA10

No disorders were found for CHRNA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRNA10 Gene

Publications for CHRNA10 Gene

  1. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PMID: 17559419) Rigbi A. … Lerer B. (Genes Brain Behav. 2008) 3 22 46 64
  2. Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). (PMID: 11350119) Lustig L.R. … Fuchs P.A. (Genomics 2001) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
  5. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (PMID: 20584212) Saccone N.L. … Bierut L.J. (Genes Brain Behav. 2010) 3 46 64

Products for CHRNA10 Gene

Sources for CHRNA10 Gene

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