CHRNA10 Gene

Aliases
for CHRNA10 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC11M004258 GC11M003952 GC11M003646 GC11M003651 GC11M003644 GC11M003645 GC11M003649 GC11M003654 GC11M003687 GC11M003420 GC11M003688 GC11M003691

Summaries
for CHRNA10 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CHRNA10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmid: CHRNA10 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRNA10

CHRNA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M003699:  view genomic region     (about GC identifiers)

Proteins
for CHRNA10 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CHRNA10: NX_Q9GZZ6

Explore proteomics data for CHRNA10 at MOPED

Post-translational modifications: 

CHRNA10 Human Recombinant Protein Products:

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	Novus Biologicals CHRNA10 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CHRNA10
	Search GeneTex for Proteins for CHRNA10
	Search antibodies-online for proteins for CHRNA10
	antibodies-online peptides for CHRNA10

CHRNA10 Antibody Products:

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	antibodies-online antibodies for CHRNA10 (42 products)

CHRNA10 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for CHRNA10
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CHRNA10
	antibodies-online kits for CHRNA10 (6 products)

Domains /
Families
for CHRNA10 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9GZZ6

Find genes that share domains with CHRNA10           About GenesLikeMe

Function
for CHRNA10 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Chrna10)

genOway: Develop your customized and physiologically relevant rodent model for CHRNA10

miRNA Products:		Block miRNA regulation of human, mouse, rat CHRNA10 using miScript Target Protectors
		8 qRT-PCR Assays for microRNAs that regulate CHRNA10:
		hsa-miR-647 hsa-miR-875-3p hsa-miR-185 hsa-miR-4306 hsa-miR-4326 hsa-miR-3175 hsa-miR-1299 hsa-miR-3150a-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CHRNA10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CHRNA10
		Predesigned siRNA for gene silencing in human, mouse, rat CHRNA10

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CHRNA10

Clone Products:		OriGene clones in human, mouse for CHRNA10 (see all 6) OriGene ORF clones in mouse, rat for CHRNA10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHRNA10 (NM_020402)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRNA10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNA10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CHRNA10
		Browse ESI BIO Cell Lines and PureStem Progenitors for CHRNA10

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA10

Localization
for CHRNA10 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
endoplasmic reticulum	1
extracellular	1

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Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

Pathways & Interactions
for CHRNA10 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CHRNA10 About     See pathways by source

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	SuperPath	Contained pathways About
1	CREB Pathway	Intracellular Calcium Signaling 0.50
2	Nanog in Mammalian ESC Pluripotency	eNOS Signaling 0.48
3	Peptide ligand-binding receptors	Neuroactive ligand-receptor interaction 0.36

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CHRNA10

	eNOS Signaling
	Intracellular Calcium Signaling

1 Kegg Pathway  (Kegg details for CHRNA10)

Neuroactive ligand-receptor interaction

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for CHRNA10 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CHRNA10 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CHRNA10 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CHRNA10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for CHRNA10 OriGene qSTAR qPCR primer pairs in human, mouse for CHRNA10
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHRNA10
		QuantiTect SYBR Green Assays in human, mouse, rat CHRNA10
		QuantiFast Probe-based Assays in human, mouse, rat CHRNA10

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA10

Orthologs
for CHRNA10 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CHRNA10 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CHRNA10 gene

HTR3E²  HTR3A²  CHRNA9²  HTR3B²  ZACN²  CHRNA7²  CHRFAM7A²  HTR3C²  

HTR3D²  

Selected SIMAP similar genes for CHRNA10 using alignment to 4 protein entries:     ACH10_HUMAN (see all proteins) (see all similar genes):

CHRNA9    CHRNA7-2    CHRNA5    HTR3B    CHRNA1    CHRNB4

CHRNA4    CHRNB3    HTR3A    CHRNE    CHRNA3    CHRNA6

CHRNA7    CHRNG    CHRNB2    CHRNA2    CHRNB1    CHRFAM7A

Find genes that share paralogs with CHRNA10           About GenesLikeMe

Genomic Variants
for CHRNA10 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CHRNA10 (see all 253)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1417311461,2		--	3686393(+)	TTTTTG/TTTAAG	1	--	int1		0	--	--	--	--
rs1900259811,2		--	3686415(+)	TAGCAG/TTGGGG	1	--	int1		0	--	--	--	--
rs785582391,2	C,F	--	3686429(+)	TATATA/GCCAAC	1	--	int1		2		WA EA	238
rs122230501,2	C,F	--	3686640(+)	gcaaaT/Gtcaca	1	--	int1		3		CSA WA EA	240
rs560845601,2	C,F	--	3686727(-)	GCTGGC/TGCAAG	1	--	int1		2		EU NA	468
rs1462786461,2		--	3686778(+)	TCCACC/TACCAC	1	--	int1		0	--	--	--	--
rs1393841001,2		--	3686801(+)	TAACAA/CAGGGC	1	--	int1		0	--	--	--	--
rs122699601,2	C,F	--	3686809(+)	GGCATC/TGAGGA	1	--	int1		2		EU NA	492
rs556931851,2	C,F	--	3686859(-)	CATTTG/CGCCCC	1	--	ut31		2		EU WA	500
rs122215251,2	C,F,A,H	--	3686944(+)	GGTAAC/GAGCCA	1	--	ut31 ese3		21		NS EA NA EU CSA WA	2732

HapMap Linkage Disequilibrium report for CHRNA10 (3686817 - 3692614 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for CHRNA10:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv428247	CNV	Loss	18775914
nsv482156	CNV	Loss	20164927
nsv832052	CNV	Loss	17160897
nsv526441	CNV	Gain	19592680
nsv832051	CNV	Gain	17160897
essv2992	CNV	CNV	17122850
dgv337e1	CNV	Complex	17122850
dgv336e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing CHRNA10

DNA2.0 Custom Variant and Variant Library Synthesis for CHRNA10

Disorders / Diseases
for CHRNA10 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for CHRNA10 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). (PubMed id 11350119)^{1, 2, 9} Lustig L.R.... Fuchs P.A. (Genomics 2001)
2. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PubMed id 17559419)^{1, 4, 9} Rigbi A....Lerer B. (Genes Brain Behav. 2008)
3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)^{1, 4} He C....Hunter D.J. (Hum. Genet. 2010)
4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
5. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (PubMed id 20584212)^{1, 4} Saccone N.L....Bierut L.J. (Genes Brain Behav. 2010)
6. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. (PubMed id 19259974)^{1, 4} Saccone N.L....Bierut L.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
7. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)^{1, 4} Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
8. No evidence for association between 19 cholinergic genes and bipolar disorder. (PubMed id 17373692)^{1, 4} Shi J....Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
9. Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. (PubMed id 15531379)^{1, 2} Peng H....Lustig L.R. (Life Sci. 2004)
10. A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. (PubMed id 11752216)^{1, 2} Sgard F.... Besnard F. (Mol. Pharmacol. 2002)

External Searches for CHRNA10 gene

Genome Databases showing CHRNA10 gene

Other Databases showing CHRNA10 gene

Specialized Databases showing CHRNA10 gene

Products
for CHRNA10 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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