Aliases for CHRNA10 Gene
Aliases for CHRNA10 Gene
- Cholinergic Receptor Nicotinic Alpha 10 Subunit 2 3 5
- Acetylcholine Receptor, Nicotinic, Alpha 10 (Neuronal) 2
- Cholinergic Receptor, Nicotinic, Alpha Polypeptide 10 2
- Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal) 2
- Nicotinic Acetylcholine Receptor Subunit Alpha-10 4
- Cholinergic Receptor, Nicotinic Alpha 10 2
- NACHR Alpha-10 4
- NACHRA10 4
External Ids for CHRNA10 Gene
- HGNC: 13800
- Entrez Gene: 57053
- Ensembl: ENSG00000129749
- OMIM: 606372
- UniProtKB: Q9GZZ6
Previous GeneCards Identifiers for CHRNA10 Gene
- GC11M004258
- GC11M003952
- GC11M003646
- GC11M003651
- GC11M003644
- GC11M003645
- GC11M003649
- GC11M003654
- GC11M003687
- GC11M003420
- GC11M003688
- GC11M003691
Summaries for CHRNA10 Gene
GeneCards Summary for CHRNA10 Gene
CHRNA10 (Cholinergic Receptor Nicotinic Alpha 10 Subunit) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and CREB Pathway. GO annotations related to this gene include receptor binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is CHRNA9.
UniProtKB/Swiss-Prot for CHRNA10 Gene
-
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA10 Gene
Genomics for CHRNA10 Gene
Regulatory Elements for CHRNA10 Gene
Enhancers for CHRNA10 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G003830 | 1.8 | FANTOM5 ENCODE dbSUPER | 9.6 | -163.1 | -163101 | 12.5 | CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D | RHOG NUP98 RRM1 ENSG00000206976 ART1 ART5 CHRNA10 STIM1 ENSG00000230593 ENSG00000236710 |
| GH11G003824 | 1.2 | ENCODE dbSUPER | 9.6 | -152.9 | -152948 | 3.2 | HDGF HNRNPUL1 ATF1 CREB3L1 ARNT AGO1 ARID4B ZNF766 CBX5 GATA2 | NUP98 ART1 ART5 CHRNA10 GC11P003826 GC11P003814 |
| GH11G003721 | 0.9 | Ensembl ENCODE | 10.6 | -49.6 | -49637 | 2.5 | PAF1 SIX4 JUN BHLHE40 MAX SIN3A DPF2 JUND CTBP1 FOS | NUP98 RNU7-50P CHRNA10 ART5 RNU6-1143P GC11P003749 |
| GH11G003709 | 0.5 | ENCODE | 11.1 | -37.2 | -37157 | 1.7 | JUND HNF4G KDM1A HNF4A | CHRNA10 NUP98 ART5 RNU6-1143P GC11P003701 |
| GH11G003812 | 0.5 | FANTOM5 | 10 | -139.0 | -138960 | 0.1 | TCF12 NCOR1 NR2F6 RBFOX2 | RHOG RNU7-50P STIM1 ENSG00000206976 CHRNA10 NUP98 PGAP2 RRM1 GC11P003814 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CHRNA10 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CHRNA10 gene promoter:
Regulatory Element Products
Genomic Location for CHRNA10 Gene
- Chromosome:
- 11
- Start:
- 3,665,587 bp from pter
- End:
- 3,673,208 bp from pter
- Size:
- 7,622 bases
- Orientation:
- Minus strand
Genomic View for CHRNA10 Gene
Genes around CHRNA10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by Ensembl
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC
CHRNA10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHRNA10 Gene
Proteins for CHRNA10 Gene
-
Protein details for CHRNA10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9GZZ6-ACH10_HUMAN
- Recommended name:
- Neuronal acetylcholine receptor subunit alpha-10
- Protein Accession:
- Q9GZZ6
Protein attributes for CHRNA10 Gene
- Size:
- 450 amino acids
- Molecular mass:
- 49705 Da
- Quaternary structure:
-
- Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. Interacts with the conotoxin GeXXA (PubMed:26395518). Interacts with the alpha-conotoxin RgIA (By similarity).
- Miscellaneous:
-
- The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).
Post-translational modifications for CHRNA10 Gene
Other Protein References for CHRNA10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CHRNA10
- Invitrogen Antibodies for CHRNA10
- antibodies-online Antibodies for CHRNA10: See all 52
- GeneTex CHRNA10 antibody for CHRNA10
Protein Products
-
OriGene Purified Proteins for CHRNA10
- Search Origene for MassSpec and Protein Over-expression Lysates for CHRNA10
- Origene Custom Protein Services for CHRNA10
- Novus Biologicals lysates for CHRNA10
- Search GeneTex for Proteins for CHRNA10
No data available for DME Specific Peptides for CHRNA10 Gene
Domains & Families for CHRNA10 Gene
Gene Families for CHRNA10 Gene
- HGNC:
- IUPHAR :
Protein Domains for CHRNA10 Gene
Suggested Antigen Peptide Sequences for CHRNA10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9GZZ6UniProtKB/Swiss-Prot:
ACH10_HUMAN :- Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
- Family:
-
- Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
Function for CHRNA10 Gene
Molecular function for CHRNA10 Gene
- UniProtKB/Swiss-Prot Function:
- Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | TAS | 11350119 |
| GO:0005216 | ion channel activity | IEA | -- |
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA | -- |
| GO:0005262 | calcium channel activity | IEA | -- |
| GO:0022848 | acetylcholine-gated cation-selective channel activity | IEA | -- |
Phenotypes for CHRNA10 Gene
- MGI mutant phenotypes for CHRNA10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CHRNA10:
Animal Models for CHRNA10 Gene
- MGI Knock Outs for CHRNA10:
-
- Chrna10 tm1Jbou
Animal Model Products
-
Taconic Biosciences Mouse Models for CHRNA10
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHRNA10
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHRNA10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRNA10 gene
- Search ViGene Biosciences for CHRNA10
CRISPR Products
-
OriGene CRISPR knockouts for CHRNA10
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHRNA10
- GenScript: Design CRISPR guide RNA sequences for CHRNA10
miRNA Products
- Search ViGene Biosciences for CHRNA10
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHRNA10
- Browse OriGene Inhibitory RNA Products For CHRNA10
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRNA10 gene
Clone Products
-
OriGene ORF clones in human for CHRNA10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHRNA10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRNA10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CHRNA10 (Nicotinic Acetylcholine R alpha 10/CHRNA10)
Cell Line Products
-
Horizon Cell Lines for CHRNA10
-
ViGene Biosciences adenoviral particle packaged cDNA for CHRNA10 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CHRNA10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRNA10 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHRNA10 Gene
Localization for CHRNA10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHRNA10 Gene
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005892 | acetylcholine-gated channel complex | IEA | -- |
| GO:0016020 | membrane | TAS,IEA | 11350119 |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
Pathways & Interactions for CHRNA10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Nanog in Mammalian ESC Pluripotency |
.48
|
|
| 3 | CREB Pathway | ||
Pathways by source for CHRNA10 Gene
1 KEGG pathway for CHRNA10 Gene
2 Qiagen pathways for CHRNA10 Gene
Interacting Proteins for CHRNA10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006816 | calcium ion transport | IEA | -- |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | IGI | 18420419 |
| GO:0007271 | synaptic transmission, cholinergic | TAS | 11350119 |
No data available for SIGNOR curated interactions for CHRNA10 Gene
Drugs & Compounds for CHRNA10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Nicotine | Approved | Pharma | Antagonist, antagonist, Target, agonist | 1103 | ||
| Pentolinium | Approved | Pharma | antagonist, Target | 0 | ||
| Trimethaphan | Approved | Pharma | antagonist, Target | 10 | ||
| Chloroprocaine | Approved | Pharma | Target, antagonist | 19 | ||
| Ethanol | Approved | Pharma | Target | 2137 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| alpha-Bungarotoxin |
|
Antagonist | 11032-79-4 |
|
|
|
| alpha-conotoxin RgIA |
|
Antagonist |
|
|
(2) ApexBio Compounds for CHRNA10 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ACV 1 | 740980-24-9 | |
| α-Conotoxin ImI | 156467-85-5 |
Transcripts for CHRNA10 Gene
mRNA/cDNA for CHRNA10 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (38) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHRNA10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHRNA10
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHRNA10
- GenScript: Design CRISPR guide RNA sequences for CHRNA10
miRNA Products
- Search ViGene Biosciences for CHRNA10
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CHRNA10
- Browse OriGene Inhibitory RNA Products For CHRNA10
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRNA10 gene
Clone Products
-
OriGene ORF clones in human for CHRNA10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHRNA10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRNA10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CHRNA10 (Nicotinic Acetylcholine R alpha 10/CHRNA10)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: |
Expression for CHRNA10 Gene
mRNA differential expression in normal tissues according to GTEx for CHRNA10 Gene
This gene is overexpressed in Muscle - Skeletal (x18.1).
NURSA nuclear receptor signaling pathways regulating expression of CHRNA10 Gene:
CHRNA10SOURCE GeneReport for Unigene cluster for CHRNA10 Gene:
Hs.732806mRNA Expression by UniProt/SwissProt for CHRNA10 Gene:
Q9GZZ6-ACH10_HUMAN
Tissue specificity:
Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.
Evidence on tissue expression from TISSUES for CHRNA10 Gene
- Muscle(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CHRNA10
-
OriGene qPCR primer pairs for CHRNA10
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRNA10 Gene
Orthologs for CHRNA10 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHRNA10 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CHRNA10 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Chrna10 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chrna10 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CHRNA10 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CHRNA10 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CHRNA10 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHRNA10 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | chrna10 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | chrna10a 34 |
|
||
| CR847523.1 35 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | nAcRbeta-21C 35 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | acr-21 34 |
|
||
| acr-7 36 |
|
|
|||
| F18G5.4 36 |
|
|
|||
| deg-3 36 |
|
|
|||
| acr-22 36 |
|
|
|||
| Y73F8A.30 36 |
|
|
|||
| acr-5 36 |
|
|
|||
| acr-17 36 |
|
|
|||
| C04C3.2 36 |
|
|
|||
| acr-18 36 |
|
|
|||
| lgc-5 35 |
|
ManyToMany |
- Species where no ortholog for CHRNA10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CHRNA10 Gene
Paralogs for CHRNA10 Gene
(19) SIMAP similar genes for CHRNA10 Gene using alignment to 4 proteins:
Variants for CHRNA10 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000262127 | -- | 3,667,972(+) | CCCTT(A/C)CTTGC | intron-variant | |
| rs1001105716 | -- | 3,671,999(+) | AGCTC(A/C)GGCCC | upstream-variant-2KB, utr-variant-5-prime | |
| rs1001123470 | -- | 3,672,868(+) | GAAAT(C/T)CAACA | upstream-variant-2KB, utr-variant-5-prime | |
| rs1001562591 | -- | 3,673,120(+) | CAGGC(A/G)TGAGC | upstream-variant-2KB, utr-variant-5-prime | |
| rs1001801412 | -- | 3,671,257(+) | CTGCA(A/G)GGAGT | reference, missense, utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759796 | CNV | gain+loss | 17122850 |
| esv3625147 | CNV | gain | 21293372 |
| esv3625148 | CNV | gain | 21293372 |
| nsv1046356 | CNV | gain | 25217958 |
| nsv428247 | CNV | loss | 18775914 |
| nsv482156 | CNV | loss | 20164927 |
| nsv526441 | CNV | gain | 19592680 |
| nsv832051 | CNV | gain | 17160897 |
| nsv832052 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.47;
64.23% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CHRNA10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CHRNA10
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA10 Gene
Disorders for CHRNA10 Gene
Relevant External Links for CHRNA10
No disorders were found for CHRNA10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRNA10 Gene
Publications for CHRNA10 Gene
- Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PMID: 17559419) Rigbi A. … Lerer B. (Genes Brain Behav. 2008) 3 22 46 64
- Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). (PMID: 11350119) Lustig L.R. … Fuchs P.A. (Genomics 2001) 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
- Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (PMID: 20584212) Saccone N.L. … Bierut L.J. (Genes Brain Behav. 2010) 3 46 64
Products for CHRNA10 Gene
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- Custom Antibody ServicesOriGene Antibodies for CHRNA10
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- OriGene Purified Proteins for CHRNA10
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- Browse OriGene Inhibitory RNA Products For CHRNA10
- OriGene qPCR primer pairs and template standards for CHRNA10
- OriGene qPCR primer pairs for CHRNA10
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- GenScript: Next-day shipping cDNA ORF clone for CHRNA10 in any vector
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- GenScript Custom Assay Services for CHRNA10
- GenScript Custom overexpressing Cell Line Services for CHRNA10
- GenScript: Design CRISPR guide RNA sequences for CHRNA10
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Novus Biologicals lysates for CHRNA10
- Novus Biologicals
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- Taconic Biosciences Mouse Models for CHRNA10
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CHRNA10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CHRNA10
- GeneTex CHRNA10 antibody for CHRNA10
- Search GeneTex for Proteins for CHRNA10
- ViGene Biosciences adenoviral particle packaged cDNA for CHRNA10 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CHRNA10 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CHRNA10 gene
- Search ViGene Biosciences for CHRNA10
- Horizon Cell Lines for CHRNA10
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHRNA10
- VectorBuilder custom plasmid, inducible vectors for CHRNA10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRNA10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CHRNA10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer