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CHRNA10 Gene(Protein Coding)

Cholinergic Receptor Nicotinic Alpha 10 Subunit

GCID:
GC11M003699
GIFtS:
55
Genes Participants
UDN Logo

Aliases for CHRNA10 Gene

Aliases for CHRNA10 Gene

  • Cholinergic Receptor Nicotinic Alpha 10 Subunit 2 3
  • Cholinergic Receptor, Nicotinic Alpha 10 2 5
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 10 2
  • Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal) 2
  • Nicotinic Acetylcholine Receptor Subunit Alpha-10 4
  • Acetylcholine Receptor 2
  • Alpha 10 (Neuronal) 2
  • NACHR Alpha-10 4
  • Nicotinic 2
  • NACHRA10 4

External Ids for CHRNA10 Gene

Previous GeneCards Identifiers for CHRNA10 Gene

  • GC11M004258
  • GC11M003952
  • GC11M003646
  • GC11M003651
  • GC11M003644
  • GC11M003645
  • GC11M003649
  • GC11M003654
  • GC11M003687
  • GC11M003420
  • GC11M003688
  • GC11M003691

Summaries for CHRNA10 Gene

GeneCards Summary for CHRNA10 Gene

CHRNA10 (Cholinergic Receptor Nicotinic Alpha 10 Subunit) is a Protein Coding gene. Diseases associated with CHRNA10 include Nicotine Dependence, Protection Against. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include receptor binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for CHRNA10 Gene

  • Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Gene Wiki entry for CHRNA10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA10 Gene

Genomics for CHRNA10 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CHRNA10 Gene

Enhancers for CHRNA10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CHRNA10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CHRNA10 gene promoter:

Genomic Location for CHRNA10 Gene

Chromosome:
11
Start:
3,665,587 bp from pter
End:
3,673,208 bp from pter
Size:
7,622 bases
Orientation:
Minus strand

Genomic View for CHRNA10 Gene

Genes around CHRNA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRNA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRNA10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CHRNA10 Gene

Proteins for CHRNA10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CHRNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZZ6-ACH10_HUMAN
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-10
    Protein Accession:
    Q9GZZ6

    Protein attributes for CHRNA10 Gene

    Size:
    450 amino acids
    Molecular mass:
    49705 Da
    Quaternary structure:
    • Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers.
    Miscellaneous:
    • The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

neXtProt entry for CHRNA10 Gene

Proteomics data for CHRNA10 Gene at MOPED

Post-translational modifications for CHRNA10 Gene

  • Glycosylation at Asn 40 and Asn 56
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHRNA10 Gene

Domains & Families for CHRNA10 Gene

Gene Families for CHRNA10 Gene

HGNC:
IUPHAR :

Protein Domains for CHRNA10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CHRNA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZZ6

UniProtKB/Swiss-Prot:

ACH10_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
genes like me logo Genes that share domains with CHRNA10: view

Function for CHRNA10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CHRNA10 Gene

UniProtKB/Swiss-Prot Function:
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Gene Ontology (GO) - Molecular Function for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 11350119
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0015464 contributes_to acetylcholine receptor activity IBA --
GO:0042166 acetylcholine binding IBA --
genes like me logo Genes that share ontologies with CHRNA10: view

Phenotypes for CHRNA10 Gene

MGI mutant phenotypes for CHRNA10:
inferred from 1 alleles
GenomeRNAi human phenotypes for CHRNA10:
genes like me logo Genes that share phenotypes with CHRNA10: view

Animal Models for CHRNA10 Gene

MGI Knock Outs for CHRNA10:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHRNA10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHRNA10 Gene

Localization for CHRNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA10 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRNA10 Gene COMPARTMENTS Subcellular localization image for CHRNA10 gene
Compartment Confidence
plasma membrane 5
cytosol 3
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IGI --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CHRNA10: view

Pathways & Interactions for CHRNA10 Gene

genes like me logo Genes that share pathways with CHRNA10: view

Pathways by source for CHRNA10 Gene

1 KEGG pathway for CHRNA10 Gene
2 Qiagen pathways for CHRNA10 Gene

Interacting Proteins for CHRNA10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000250699%0d%0a9606.ENSP00000384892%0d%0a9606.ENSP00000313490%0d%0a9606.ENSP00000325296%0d%0a
Selected Interacting proteins: ENSP00000250699 for CHRNA10 Gene via STRING

Gene Ontology (GO) - Biological Process for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IBA --
GO:0007271 synaptic transmission, cholinergic IEA,TAS 11350119
GO:0034220 ion transmembrane transport IEA --
GO:0042472 inner ear morphogenesis IEA --
genes like me logo Genes that share ontologies with CHRNA10: view

No data available for SIGNOR curated interactions for CHRNA10 Gene

Drugs & Compounds for CHRNA10 Gene

Products:

  1. Drug

(17) Drugs for CHRNA10 Gene - From: DrugBank, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotine Approved Pharma Antagonist, antagonist, Target, agonist 990
Pentolinium Approved Pharma antagonist, Target 0
Trimethaphan Approved Pharma antagonist, Target 9
Chloroprocaine Approved Pharma Target, antagonist 16
Ethanol Approved Pharma Target 1924

(2) Additional Compounds for CHRNA10 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-bungarotoxin
Antagonist
alpha-conotoxin RgIA
Antagonist
genes like me logo Genes that share compounds with CHRNA10: view

Transcripts for CHRNA10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CHRNA10 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(38) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHRNA10 Gene

Cholinergic receptor, nicotinic, alpha 10 (neuronal):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA10 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2:

Relevant External Links for CHRNA10 Gene

GeneLoc Exon Structure for
CHRNA10
ECgene alternative splicing isoforms for
CHRNA10

Expression for CHRNA10 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CHRNA10 Gene

mRNA expression in normal human tissues for CHRNA10 Gene
mRNA expression by BioGPS for CHRNA10 GenemRNA expression by GTEx for CHRNA10 Gene

mRNA differential expression in normal tissues according to GTEx for CHRNA10 Gene

This gene is overexpressed in Muscle - Skeletal (x18.1).

SOURCE GeneReport for Unigene cluster for CHRNA10 Gene Hs.732806

mRNA Expression by UniProt/SwissProt for CHRNA10 Gene

Q9GZZ6-ACH10_HUMAN
Tissue specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.
genes like me logo Genes that share expression patterns with CHRNA10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CHRNA10 Gene

Orthologs for CHRNA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CHRNA10 35
  • 91.16 (n)
  • 94.64 (a)
CHRNA10 36
  • 92 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Chrna10 35
  • 86.06 (n)
  • 91.95 (a)
Chrna10 16
Chrna10 36
  • 92 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CHRNA10 35
  • 99.33 (n)
  • 99.11 (a)
CHRNA10 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Chrna10 35
  • 85.16 (n)
  • 90.6 (a)
dog
(Canis familiaris)
 Mammalia CHRNA10 36
  • 54 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CHRNA10 36
  • 78 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CHRNA10 36
  • 63 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CHRNA10 35
  • 71.04 (n)
  • 67.92 (a)
CHRNA10 36
  • 65 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 62 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia chrna10 35
  • 64.95 (n)
  • 64.17 (a)
zebrafish
(Danio rerio)
 Actinopterygii chrna10a 35
  • 61.04 (n)
  • 59.91 (a)
CR847523.1 36
  • 52 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta nAcRbeta-21C 36
  • 25 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea acr-17 37
  • 30 (a)
acr-18 37
  • 28 (a)
acr-22 37
  • 31 (a)
acr-5 37
  • 30 (a)
acr-7 37
  • 38 (a)
C04C3.2 37
  • 28 (a)
deg-3 37
  • 33 (a)
F18G5.4 37
  • 35 (a)
Y73F8A.30 37
  • 30 (a)
acr-21 35
  • 48.91 (n)
  • 44.24 (a)
lgc-5 36
  • 23 (a)
 ManyToMany
Species with no ortholog for CHRNA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA10 Gene

ENSEMBL:
Gene Tree for CHRNA10 (if available)
TreeFam:
Gene Tree for CHRNA10 (if available)

Paralogs for CHRNA10 Gene

Paralogs for CHRNA10 Gene

(19) SIMAP similar genes for CHRNA10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHRNA10: view

Variants for CHRNA10 Gene

Sequence variations from dbSNP and Humsavar for CHRNA10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2231547 - 3,666,396(-) AGGGG(A/C)GCCCT reference, missense
rs2231528 -- 3,672,180(-) AGTCC(C/T)GCACT upstream-variant-2KB, utr-variant-5-prime
rs2231529 -- 3,672,023(-) CTGTA(C/T)TCTCC upstream-variant-2KB, utr-variant-5-prime
rs2231530 -- 3,671,954(-) TCAAG(C/T)CCCAG upstream-variant-2KB, utr-variant-5-prime
rs2231531 -- 3,671,906(-) AGGCA(C/T)GGTGT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CHRNA10 Gene

Variant ID Type Subtype PubMed ID
dgv336e1 CNV Complex 17122850
nsv832051 CNV Gain 17160897
essv2992 CNV CNV 17122850
dgv337e1 CNV Complex 17122850
nsv428247 CNV Loss 18775914
nsv832052 CNV Loss 17160897
nsv526441 CNV Gain 19592680
nsv482156 CNV Loss 20164927

Variation tolerance for CHRNA10 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CHRNA10 Gene

Disorders for CHRNA10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CHRNA10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nicotine dependence, protection against
  • nicotine dependence
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CHRNA10

Genetic Association Database (GAD)
CHRNA10
Human Genome Epidemiology (HuGE) Navigator
CHRNA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRNA10
genes like me logo Genes that share disorders with CHRNA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHRNA10 Gene

Publications for CHRNA10 Gene

  1. Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). (PMID: 11350119) Lustig L.R. … Fuchs P.A. (Genomics 2001) 3 4 23 67
  2. Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. (PMID: 23641218) Hendrickson L.M. … Tapper A.R. (Front Psychiatry 2013) 25 26
  3. Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. (PMID: 20400469) Jackson K.J. … Damaj M.I. (J. Pharmacol. Exp. Ther. 2010) 25 26
  4. Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. (PMID: 19560048) Mansvelder H.D. … Role L.W. (Semin. Cell Dev. Biol. 2009) 25 26
  5. Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. (PMID: 20081230) Zaniewska M. … Filip M. (Pharmacol Rep 2009) 25 26

Products for CHRNA10 Gene

Sources for CHRNA10 Gene

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