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CHRNA10 Gene

protein-coding GIFtS: 54
GCID: GC11M003699

Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal)

(Previous names: cholinergic receptor, nicotinic, alpha polypeptide 10)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal)¹ ²		Alpha 10 (Neuronal)¹
Cholinergic Receptor, Nicotinic, Alpha Polypeptide 10¹ ²		nicotinic¹
Nicotinic Acetylcholine Receptor Subunit Alpha-10² ³		Acetylcholine Receptor, Nicotinic, Alpha 10 (Neuronal)²
NACHR Alpha-10² ³		Neuronal Acetylcholine Receptor Subunit Alpha-10²
Acetylcholine Receptor¹		NACHRA10³

External Ids:	HGNC: 13800¹	Entrez Gene: 57053²	Ensembl: ENSG00000129749⁷	OMIM: 606372⁵	UniProtKB: Q9GZZ6³

Export aliases for CHRNA10 gene to outside databases

Previous GC identifers: GC11M004258 GC11M003952 GC11M003646 GC11M003651 GC11M003644 GC11M003645 GC11M003649 GC11M003654 GC11M003687 GC11M003420 GC11M003688 GC11M003691

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CHRNA10 Gene:

CHRNA10 (cholinergic receptor, nicotinic, alpha 10 (neuronal)) is a protein-coding gene. Diseases associated with CHRNA10 include nicotine dependence, and nicotine addiction. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and receptor binding. An important paralog of this gene is HTR3E.

UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6

Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may

induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting

channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium,

the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may

lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the

range of dynamic hearing. This may protect against acoustic trauma

Gene Wiki entry for CHRNA10 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Regulatory transcription factor binding sites in the CHRNA10 gene promoter:
p53 MIF-1 AP-4 FOXL1 HEN1 CP2 FOXJ2 (long isoform) FOXJ2 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHRNA10 promoter sequence

Search Chromatin IP Primers for CHRNA10

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRNA10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5

CHRNA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRNA10 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M003699: view genomic region (about GC identifiers)

Start:	3,686,817 bp from pter	End:	3,692,614 bp from pter
Size:	5,798 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6 (See protein sequence)

Recommended Name: Neuronal acetylcholine receptor subunit alpha-10 precursor

Size: 450 amino acids; 49705 Da

Subunit: Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be

composed of CHRNA9-CHRNA10 heterooligomers

Miscellaneous: The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological

profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine

(a muscarinic acetylcholine receptor antagonist)

Explore the universe of human proteins at neXtProt for CHRNA10: NX_Q9GZZ6

Explore proteomics data for CHRNA10 at MOPED

Post-translational modifications:

Glycosylation² at Asn40, Asn56

See CHRNA10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_065135.2

ENSEMBL proteins:

ENSP00000250699 ENSP00000437107 ENSP00000432757

CHRNA10 Human Recombinant Protein Products:

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CHRNA10 Assay Products:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CHRN: Ligand-gated ion channels / Acetylcholine receptors, nicotinic

CHR: Cholinergic receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: alpha10

Nicotinic acetylcholine receptors

Selected InterPro protein domains (see all 6):

IPR027361 Acetylcholine_rcpt_TM

IPR002394 Nicotinic_acetylcholine_rcpt

IPR018000 Neurotransmitter_ion_chnl_CS

IPR006201 Neur_channel

IPR006202 Neur_chan_lig-bd

Graphical View of Domain Structure for InterPro Entry Q9GZZ6

ProtoNet protein and cluster: Q9GZZ6

2 Blocks protein domains:

IPB002394 Nicotinic acetylcholine receptor signature

IPB006201 Neurotransmitter-gated ion-channel

UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6

Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1)

subfamily. Alpha-10/CHRNA10 sub-subfamily

CHRNA10 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ACH10_HUMAN, Q9GZZ6

Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may

induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting

channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium,

the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may

lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the

range of dynamic hearing. This may protect against acoustic trauma

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004889	acetylcholine-activated cation-selective channel activity	IEA	--
GO:0005102	receptor binding	TAS	11350119
GO:0005230	extracellular ligand-gated ion channel activity	--	--
GO:0005262	calcium channel activity	IEA	--

CHRNA10 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Chrna10):

hearing/vestibular/ear

nervous system

CHRNA10 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Chrna10^tm1Jbou for CHRNA10

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHRNA10

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHRNA10

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHRNA10

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHRNA10

miRNA Products:		Block miRNA regulation of human, mouse, rat CHRNA10 using miScript Target Protectors
		8 qRT-PCR Assays for microRNAs that regulate CHRNA10:
		hsa-miR-647 hsa-miR-875-3p hsa-miR-185 hsa-miR-4306 hsa-miR-4326 hsa-miR-3175 hsa-miR-1299 hsa-miR-3150a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CHRNA10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CHRNA10
		Predesigned siRNA for gene silencing in human, mouse, rat CHRNA10

Gene Editing
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		GenScript: all cDNA clones in your preferred vector: CHRNA10 (NM_020402)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRNA10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRNA10

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		Browse ESI BIO Cell Lines and PureStem Progenitors for CHRNA10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA10

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ACH10_HUMAN, Q9GZZ6: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable).

Cell membrane; Multi-pass membrane protein (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
endoplasmic reticulum	1
extracellular	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	TAS	11350119
GO:0016021	integral component of membrane	IEA	--
GO:0030054	cell junction	IEA	--
GO:0030424	axon	IEA	--
GO:0043204	perikaryon	IEA	--

CHRNA10 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CHRNA10 About

See pathways by source

SuperPath

Contained pathways About

CREB Pathway

Intracellular Calcium Signaling

0.50

Nanog in Mammalian ESC Pluripotency

eNOS Signaling

0.48

Peptide ligand-binding receptors

Neuroactive ligand-receptor interaction

0.36

Calcium channels

Calcium channels

Pathways by source See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CHRNA10

	eNOS Signaling
	Intracellular Calcium Signaling

1 Kegg Pathway (Kegg details for CHRNA10):

Neuroactive ligand-receptor interaction

CHRNA10 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for CHRNA10
Interactions:

Search GeneGlobe Interaction Network for CHRNA10

Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	--	--
GO:0006811	ion transport	--	--
GO:0007204	positive regulation of cytosolic calcium ion concentration	IGI	18420419
GO:0007271	synaptic transmission, cholinergic	TAS	11350119
GO:0042127	regulation of cell proliferation	TAS	11350119

CHRNA10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CHRNA10 (ACH10)

1 HMDB Compound for CHRNA10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

7 DrugBank Compounds for CHRNA10 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Galantamine	(-)-Galanthamine (see all 3)	357-70-0	target	allosteric modulator	12137632 11129124 12481195 20480924 12177686 10971048
Nicotine	L-Nicotine (see all 2)	54-11-5	target	agonist	19560048 20081230 20400469 11006350
Pentolinium	Pentolinium tartrate (see all 3)	52-62-0	target	antagonist	17139284 8516349 17016423 7761270
Trimethaphan	Thimethaphan (see all 3)	7187-66-8	target	antagonist	8232788 17139284 17016423 7963258
Chloroprocaine	Chloroprocain (see all 3)	133-16-4	target	antagonist	17139284 17016423
Methadone	(+/-)-Methadone (see all 8)	76-99-3	target	antagonist	17139284 17016423
Succinylcholine	Scoline (see all 3)	306-40-1	target	agonist	16571968

6 IUPHAR Ligands for CHRNA10 (alpha10) About this table

Ligand	Type	Action	Pubmed IDs
alpha-conotoxin RgIA	Antagonist	Antagonist	--
nicotine	Antagonist	Antagonist	--
[³H]methyllycaconitine	None	None	--
alpha-bungarotoxin	Antagonist	Antagonist	--
strychnine	Antagonist	Antagonist	--
muscarine	Antagonist	Antagonist	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CHRNA10 gene:

NM_020402.2

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000250699(uc001lyf.3 uc010qxt.2 uc010qxu.2) ENST00000534359

ENST00000526599 ENST00000493827

miRNA Products:		Block miRNA regulation of human, mouse, rat CHRNA10 using miScript Target Protectors
		8 qRT-PCR Assays for microRNAs that regulate CHRNA10:
		hsa-miR-647 hsa-miR-875-3p hsa-miR-185 hsa-miR-4306 hsa-miR-4326 hsa-miR-3175 hsa-miR-1299 hsa-miR-3150a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CHRNA10 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: CHRNA10 (NM_020402)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRNA10
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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CHRNA10
		QuantiTect SYBR Green Assays in human, mouse, rat CHRNA10
		QuantiFast Probe-based Assays in human, mouse, rat CHRNA10

Selected AceView cDNA sequences (see all 38):

AI146549 AI139700 AW207378 BQ010406 AA491394 BF516446 BX096928 BM665196

AI673104 AW135678 AJ295237 AI939323 BM702479 BF516351 BF059093 BF343450

BF345692 BC033833 AJ278118 BF057531 BE855541 AA262389 AF199235 AI660069

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA10 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5
SP1:							-				-
SP2:

ECgene alternative splicing isoforms for CHRNA10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CHRNA10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

CHRNA10 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CHRNA10 Protein Expression

Genevestigator expression for CHRNA10

UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6

Tissue specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral

blood lymphocytes

Custom PCR Arrays for CHRNA10

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		QuantiFast Probe-based Assays in human, mouse, rat CHRNA10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRNA10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CHRNA10 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Chrna10^{1 , 5}	cholinergic receptor, nicotinic, alpha polypeptide more^{1, 5}	86.06(n)¹ 91.95(a)¹		7 (54.71 cM)⁵ 504186¹ NM_001081424.1¹ NP_001074893.1¹ 102111266⁵
chicken (Gallus gallus)	Aves	CHRNA10¹	cholinergic receptor, nicotinic, alpha 10	71.04(n) 67.92(a)		430628 NM_001101036.1 NP_001094506.1
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	62(a)	many ↔ many	GL344444.1(2587-11603)
tropical clawed frog (Xenopus tropicalis)	Amphibia	chrna10¹	cholinergic receptor, nicotinic, alpha 10 (neuronal)	64.95(n) 64.17(a)		100487976 XM_002942872.2 XP_002942918.2
zebrafish (Danio rerio)	Actinopterygii	chrna10a¹	cholinergic receptor, nicotinic, alpha 10a	61.04(n) 59.91(a)		556507 NM_001044804.1 NP_001038269.1
fruit fly (Drosophila melanogaster)	Insecta	nAcRbeta-21C⁶	nicotinic acetylcholine receptor beta 21C	25(a)	many ↔ many	2L(545129-547096)
worm (Caenorhabditis elegans)	Secernentea	acr-7³ acr-21¹	Acetylcholine receptor³ acr-21¹	38(a) (best of 9)³ 48.91(n)¹ 44.24(a)¹		II(7845587-7849647)³ 185004¹ NM_066051.3¹ NP_498452.3¹

ENSEMBL Gene Tree for CHRNA10 (if available)
TreeFam Gene Tree for CHRNA10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CHRNA10 gene

HTR3E² HTR3A² CHRNA9² HTR3B² ZACN² CHRNA7² CHRFAM7A² HTR3C²

HTR3D²

Selected SIMAP similar genes for CHRNA10 using alignment to 4 protein entries: ACH10_HUMAN (see all proteins) (see all similar genes):

CHRNA9 CHRNA7-2 CHRNA5 HTR3B CHRNA1 CHRNB4

CHRNA4 CHRNB3 HTR3A CHRNE CHRNA3 CHRNA6

CHRNA7 CHRNG CHRNB2 CHRNA2 CHRNB1 CHRFAM7A

CHRNA10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141731146^1,2		--	3686393(+)	`TTTTTG/TTTAAG`	1	--	int¹		0	--	--	--	--
rs190025981^1,2		--	3686415(+)	`TAGCAG/TTGGGG`	1	--	int¹		0	--	--	--	--
rs78558239^1,2	C,F	--	3686429(+)	`TATATA/GCCAAC`	1	--	int¹		2		WA EA	238
rs12223050^1,2	C,F	--	3686640(+)	`gcaaaT/Gtcaca`	1	--	int¹		3		CSA WA EA	240
rs56084560^1,2	C,F	--	3686727(-)	`GCTGGC/TGCAAG`	1	--	int¹		2		EU NA	468
rs146278646^1,2		--	3686778(+)	`TCCACC/TACCAC`	1	--	int¹		0	--	--	--	--
rs139384100^1,2		--	3686801(+)	`TAACAA/CAGGGC`	1	--	int¹		0	--	--	--	--
rs12269960^1,2	C,F	--	3686809(+)	`GGCATC/TGAGGA`	1	--	int¹		2		EU NA	492
rs55693185^1,2	C,F	--	3686859(-)	`CATTTG/CGCCCC`	1	--	ut3¹		2		EU WA	500
rs12221525^1,2	C,F,A,H	--	3686944(+)	`GGTAAC/GAGCCA`	1	--	ut3¹ ese³		21		NS EA NA EU CSA WA	2732

HapMap Linkage Disequilibrium report for CHRNA10 (3686817 - 3692614 bp)

Structural Variations
Database of Genomic Variants (DGV) 8 variations for CHRNA10: About this table

Variant ID	Type	Subtype	PubMed ID
nsv428247	CNV	Loss	18775914
nsv482156	CNV	Loss	20164927
nsv832052	CNV	Loss	17160897
nsv526441	CNV	Gain	19592680
nsv832051	CNV	Gain	17160897
essv2992	CNV	CNV	17122850
dgv337e1	CNV	Complex	17122850
dgv336e1	CNV	Complex	17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606372 OMIM disorders: --

6 diseases for CHRNA10: About MalaCards

nicotine dependence nicotine addiction tonsillitis conjunctivitis

neuronitis bipolar disorder

1 disease from the University of Copenhagen DISEASES database for CHRNA10:

Nicotine dependence

CHRNA10 for disorders About GeneDecksing

Genetic Association Database (GAD): CHRNA10
Human Genome Epidemiology (HuGE) Navigator: CHRNA10 (10 documents)

Export disorders for CHRNA10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CHRNA10 gene, integrated from 10 sources (see all 33):
(articles sorted by number of sources associating them with CHRNA10)

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Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). (PubMed id 11350119)^{1, 2, 9} Lustig L.R.... Fuchs P.A. (Genomics 2001)
Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PubMed id 17559419)^{1, 4, 9} Rigbi A....Lerer B. (Genes Brain Behav. 2008)
A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)^{1, 4} He C....Hunter D.J. (Hum. Genet. 2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (PubMed id 20584212)^{1, 4} Saccone N.L....Bierut L.J. (Genes Brain Behav. 2010)
Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. (PubMed id 19259974)^{1, 4} Saccone N.L....Bierut L.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)^{1, 4} Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
No evidence for association between 19 cholinergic genes and bipolar disorder. (PubMed id 17373692)^{1, 4} Shi J....Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. (PubMed id 15531379)^{1, 2} Peng H....Lustig L.R. (Life Sci. 2004)
A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. (PubMed id 11752216)^{1, 2} Sgard F.... Besnard F. (Mol. Pharmacol. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57053	HGNC: 13800	AceView: CHRNA10	Ensembl:ENSG00000129749	euGenes: HUgn57053
ECgene: CHRNA10	Kegg: 57053	H-InvDB: CHRNA10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CHRNA10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CHRNA10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CHRNA10 gene:
Search GeneIP for patents involving CHRNA10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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CHRNA10 Gene

Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal)

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CHRNA10 Gene

Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal)

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