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Aliases for CHRNA1 Gene

Aliases for CHRNA1 Gene

  • Cholinergic Receptor, Nicotinic, Alpha 1 (Muscle) 2 3
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 1 (Muscle) 2 3
  • CMS2A 3 6
  • FCCMS 3 6
  • SCCMS 3 6
  • ACHRD 3 6
  • ACHRA 3 4
  • Acetylcholine Receptor, Nicotinic, Alpha 1 (Muscle) 3
  • Nicotinic Acetylcholine Receptor Alpha Subunit 3
  • Muscle Nicotinic Acetylcholine Receptor 3
  • Nicotinic Cholinergic Receptor Alpha 1 3
  • Acetylcholine Receptor Subunit Alpha 3
  • Acetylcholine Receptor 2
  • Alpha 1 (Muscle) 2
  • Nicotinic 2
  • CHRNA 3
  • CHNRA 4

External Ids for CHRNA1 Gene

Previous HGNC Symbols for CHRNA1 Gene


Previous GeneCards Identifiers for CHRNA1 Gene

  • GC02M173665
  • GC02M174273
  • GC02M175576
  • GC02M175815
  • GC02M175814
  • GC02M175437
  • GC02M175320
  • GC02M175612
  • GC02M167492

Summaries for CHRNA1 Gene

Entrez Gene Summary for CHRNA1 Gene

  • The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]

GeneCards Summary for CHRNA1 Gene

CHRNA1 (Cholinergic Receptor, Nicotinic, Alpha 1 (Muscle)) is a Protein Coding gene. Diseases associated with CHRNA1 include chrna1-related multiple pterygium syndrome, lethal type and chrna1-related congenital myasthenic syndrome. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include acetylcholine-activated cation-selective channel activity and acetylcholine receptor activity. An important paralog of this gene is CHRNA3.

UniProtKB/Swiss-Prot for CHRNA1 Gene

  • After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Gene Wiki entry for CHRNA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRNA1 Gene

Genomics for CHRNA1 Gene

Regulatory Elements for CHRNA1 Gene

Genomic Location for CHRNA1 Gene

174,747,592 bp from pter
174,764,472 bp from pter
16,881 bases
Minus strand

Genomic View for CHRNA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA1 Gene

Proteins for CHRNA1 Gene

  • Protein details for CHRNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acetylcholine receptor subunit alpha
    Protein Accession:
    Secondary Accessions:
    • B4DRV6
    • D3DPE8

    Protein attributes for CHRNA1 Gene

    482 amino acids
    Molecular mass:
    54546 Da
    Quaternary structure:
    • Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains

    Three dimensional structures from OCA and Proteopedia for CHRNA1 Gene

    Alternative splice isoforms for CHRNA1 Gene


neXtProt entry for CHRNA1 Gene

Proteomics data for CHRNA1 Gene at MOPED

Post-translational modifications for CHRNA1 Gene

  • Glycosylation at Asn186
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNA1 Gene

Antibody Products

No data available for DME Specific Peptides for CHRNA1 Gene

Domains for CHRNA1 Gene

Gene Families for CHRNA1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
genes like me logo Genes that share domains with CHRNA1: view

Function for CHRNA1 Gene

Molecular function for CHRNA1 Gene

GENATLAS Biochemistry:
cholinergic receptor,nicotinic,alpha 1 polypeptide,muscle
UniProtKB/Swiss-Prot Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Gene Ontology (GO) - Molecular Function for CHRNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004889 contributes_to acetylcholine-activated cation-selective channel activity ISS 8872460
GO:0005216 ion channel activity TAS 6688857
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0005515 protein binding --
GO:0015464 contributes_to acetylcholine receptor activity ISS 8872460
genes like me logo Genes that share ontologies with CHRNA1: view
genes like me logo Genes that share phenotypes with CHRNA1: view

Animal Models for CHRNA1 Gene

MGI Knock Outs for CHRNA1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CHRNA1 Gene

Localization for CHRNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA1 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CHRNA1 Gene COMPARTMENTS Subcellular localization image for CHRNA1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CHRNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005892 acetylcholine-gated channel complex ISS 8872460
GO:0009986 cell surface IDA 12928480
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CHRNA1: view

Pathways for CHRNA1 Gene

genes like me logo Genes that share pathways with CHRNA1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHRNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003009 skeletal muscle contraction IMP 8872460
GO:0006810 transport TAS 7619526
GO:0006811 ion transport --
GO:0006812 cation transport --
GO:0007165 signal transduction TAS 7619526
genes like me logo Genes that share ontologies with CHRNA1: view

Drugs for CHRNA1 Gene

(2) Drugbank Compounds for CHRNA1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (-)-Galanthamine
357-70-0 908828 Target allosteric modulator approved
  • (4-aminobutyl) guanidine
306-60-5 Target antagonist experimental, investigational

(38) ApexBio Compounds for CHRNA1 Gene

Compound Action Cas Number
Acetylcholine Chloride Major transmitter at many nervous sites [60-31-1]
Acetylcysteine Antioxidant;mucolytic agent [616-91-1]
Atropine MAChRs antagonist [5908-99-6]
Benzethonium Chloride [121-54-0]
Bethanechol chloride Muscarinic receptor agonist [590-63-6]
Decamethonium Bromide [541-22-0]
Diphemanil Methylsulfate [62-97-5]
Flavoxate hydrochloride [3717-88-2]
Galanthamine HBr Acetylcholinesterase inhibitor [1953-4-4]
Gallamine Triethiodide [65-29-2]
Hexamethonium Bromide [55-97-0]
Homatropine Bromide Muscarinic AChR antagonist [51-56-9]
Homatropine Methylbromide Muscarinic AChR antagonist [80-49-9]
Hyoscyamine [101-31-5]
Ipratropium Bromide [22254-24-6]
LY2119620 [886047-22-9]
Methscopolamine Muscarinic acetylcholine receptor blocker [155-41-9]
Neostigmine Bromide Cholinesterase inhibitor [114-80-7]
Nicotine Difartrate [65-31-6]
Nitenpyram [150824-47-8]
Orphenadrine Citrate Antiparkinsonian and analgesic drug [4682-36-4]
Otilonium Bromide [26095-59-0]
Oxybutynin [5633-20-5]
Oxybutynin chloride [1508-65-2]
Pancuronium dibromide AChR antagonist [15500-66-0]
Paroxetine HCl Antidepressant agents [78246-49-8]
Pentoxyverine Citrate [23142-01-0]
Pilocarpine HCl [54-71-7]
PNU-120596 α7 nAChR modulator,positive allosteric [501925-31-1]
Pregnenolone [145-13-1]
Rivastigmine Tartrate [129101-54-8]
Rocuronium Bromide TGF-βR I kinase inhibitor [119302-91-9]
Succinylcholine Chloride Dihydrate [6101-15-1]
Tiotropium Bromide hydrate Muscarinic antagonist [139404-48-1]
Tropicamide Antimuscarinic drug [1508-75-4]
Trospium chloride Antimuscarinic agent [10405-02-4]
Varenicline Tartrate Subtype-selective agonist of α4β2 nicotinic receptors,orally active [375815-87-5]
Vecuronium Bromide Nonpolarizing neuromuscular relaxant [50700-72-6]

(10) IUPHAR Ligand for CHRNA1 Gene

Ligand Type Action Affinity Pubmed IDs
mecamylamine Channel blocker None 6.41
gallamine Channel blocker None 6
alpha-bungarotoxin Antagonist Antagonist
[125I]alpha-bungarotoxin None None
[3H]alpha-bungarotoxin None None
alpha-conotoxin GI Antagonist Antagonist
succinylcholine Agonist Full agonist
pancuronium Antagonist Antagonist
waglerin-1 Antagonist Antagonist
alpha-conotoxin MI Antagonist Antagonist

(3) Novoseek inferred chemical compound relationships for CHRNA1 Gene

Compound -log(P) Hits PubMed IDs
alpha-bungarotoxin 75.9 3
acetylcholine 56 6
nicotine 27.7 1
genes like me logo Genes that share compounds with CHRNA1: view

Transcripts for CHRNA1 Gene

Unigene Clusters for CHRNA1 Gene

Cholinergic receptor, nicotinic, alpha 1 (muscle):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRNA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: -

Relevant External Links for CHRNA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRNA1 Gene

mRNA expression in normal human tissues for CHRNA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHRNA1 Gene

This gene is overexpressed in Muscle - Skeletal (48.7).

SOURCE GeneReport for Unigene cluster for CHRNA1 Gene Hs.434479

mRNA Expression by UniProt/SwissProt for CHRNA1 Gene

Tissue specificity: Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus
genes like me logo Genes that share expressions with CHRNA1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for CHRNA1 Gene

Orthologs for CHRNA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHRNA1 35
  • 92.85 (n)
  • 96.72 (a)
  • 97 (a)
(Canis familiaris)
Mammalia CHRNA1 35
  • 91.98 (n)
  • 96.28 (a)
  • 96 (a)
(Mus musculus)
Mammalia Chrna1 35
  • 88.91 (n)
  • 94.31 (a)
Chrna1 16
Chrna1 36
  • 94 (a)
(Pan troglodytes)
Mammalia CHRNA1 35
  • 98.41 (n)
  • 97.93 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Chrna1 35
  • 88.18 (n)
  • 93.87 (a)
(Monodelphis domestica)
Mammalia CHRNA1 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia CHRNA1 36
  • 88 (a)
(Gallus gallus)
Aves CHRNA1 35
  • 80.37 (n)
  • 86.22 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia CHRNA1 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chrna1 35
  • 72.15 (n)
  • 78.22 (a)
MGC76192 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1117 35
(Danio rerio)
Actinopterygii chrna1 35
  • 72.89 (n)
  • 79.73 (a)
chrna1 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta nAcRalpha-30D 37
  • 30 (a)
nAcRalpha-7E 37
  • 48 (a)
nAcRalpha-80B 37
  • 37 (a)
nAcRalpha-96Aa 37
  • 49 (a)
nAcRalpha-96Ab 37
  • 47 (a)
nAcRbgr-21C 37
  • 29 (a)
nAcRbgr-96A 37
  • 42 (a)
nAcRalpha-7E 36
  • 26 (a)
nAcRalpha-80B 36
  • 37 (a)
nAcRalpha-96Aa 36
  • 35 (a)
nAcRalpha-96Ab 36
  • 33 (a)
nAcRbeta-96A 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea acr-12 37
  • 42 (a)
acr-13 37
  • 30 (a)
acr-17 37
  • 33 (a)
acr-18 37
  • 24 (a)
acr-2 37
  • 40 (a)
acr-3 37
  • 35 (a)
acr-5 37
  • 27 (a)
acr-8 37
  • 32 (a)
deg-3 37
  • 29 (a)
F11C7.1 37
  • 27 (a)
F18G5.4 37
  • 31 (a)
lev-1 37
  • 37 (a)
unc-38 37
  • 39 (a)
unc-63 37
  • 42 (a)
ZK973.5 37
  • 35 (a)
acr-12 36
  • 30 (a)
acr-6 36
  • 27 (a)
acr-8 36
  • 30 (a)
lev-8 36
  • 29 (a)
unc-38 36
  • 38 (a)
unc-63 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for CHRNA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRNA1 Gene

Gene Tree for CHRNA1 (if available)
Gene Tree for CHRNA1 (if available)

Paralogs for CHRNA1 Gene

genes like me logo Genes that share paralogs with CHRNA1: view

Variants for CHRNA1 Gene

Sequence variations from dbSNP and Humsavar for CHRNA1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs753193 -- 174,753,358(+) CGCAC(A/G)CCCAC intron-variant
rs1376865 -- 174,759,869(+) ACAAC(A/G)CTTGT intron-variant
rs1376866 -- 174,763,128(+) TAAAA(C/T)ACCCA intron-variant
rs1376867 -- 174,763,328(+) CGCGC(A/G)CGCAC intron-variant
rs1376868 -- 174,763,330(+) CGCGC(A/G)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHRNA1 Gene

Variant ID Type Subtype PubMed ID
nsv470500 CNV Loss 18288195
nsv459948 CNV Loss 19166990
nsv875432 CNV Loss 21882294

Relevant External Links for CHRNA1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA1 Gene

Disorders for CHRNA1 Gene

(3) OMIM Diseases for CHRNA1 Gene (100690)


  • Multiple pterygium syndrome, lethal type (LMPS) [MIM:253290]: Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent. {ECO:0000269 PubMed:18252226}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=The alpha subunit is the main focus for antibody binding in myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
  • Myasthenic syndrome, congenital, slow-channel (SCCMS) [MIM:601462]: A common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. Congenital myasthenic syndrome slow-channel type is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes. {ECO:0000269 PubMed:16685696, ECO:0000269 PubMed:7619526, ECO:0000269 PubMed:8872460, ECO:0000269 PubMed:9158151, ECO:0000269 PubMed:9221765}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Myasthenic syndrome, congenital, fast-channel (FCCMS) [MIM:608930]: A congenital myasthenic syndrome characterized by kinetic abnormalities of the AChR. Due in most cases to mutations that decrease activity of the AChR by slowing the rate of opening of the receptor channel, speeding the rate of closure of the channel, or decreasing the number of openings of the channel during ACh occupancy. The result is failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential. {ECO:0000269 PubMed:10195214, ECO:0000269 PubMed:12588888, ECO:0000269 PubMed:15079006}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for CHRNA1 Gene

(1) Novoseek inferred disease relationships for CHRNA1 Gene

Disease -log(P) Hits PubMed IDs
myasthenia gravis 72.7 6

Relevant External Links for CHRNA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CHRNA1: view

No data available for Genatlas for CHRNA1 Gene

Publications for CHRNA1 Gene

  1. The human muscle nicotinic acetylcholine receptor alpha-subunit exist as two isoforms: a novel exon. (PMID: 1694127) Beeson D. … Newsom-Davis J. (EMBO J. 1990) 3 4 23
  2. Differential expression of human nicotinic acetylcholine receptor alpha subunit variants in muscle and non-muscle tissues. (PMID: 8441631) Talib S. … Lebkowski J.S. (Nucleic Acids Res. 1993) 3 4 23
  3. Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor. (PMID: 6688857) Noda M. … Numa S. (Nature 1983) 3 4
  4. New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. (PMID: 8872460) Engel A.G. … Sine S.M. (Hum. Mol. Genet. 1996) 3 4
  5. Cloning of a cDNA coding for the acetylcholine receptor alpha-subunit from a thymoma associated with myasthenia gravis. (PMID: 7725386) Gattenloehner S. … Kirchner T. (Thymus 1994) 3 4

Products for CHRNA1 Gene

Sources for CHRNA1 Gene

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