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Aliases for CHRM5 Gene

Aliases for CHRM5 Gene

  • Cholinergic Receptor, Muscarinic 5 2 3
  • Acetylcholine Receptor, Muscarinic 5 3
  • Muscarinic Acetylcholine Receptor M5 3
  • Acetylcholine Receptor 2
  • Muscarinic 5 2
  • HM5 3

External Ids for CHRM5 Gene

Summaries for CHRM5 Gene

Entrez Gene Summary for CHRM5 Gene

  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHRM5 Gene

CHRM5 (Cholinergic Receptor, Muscarinic 5) is a Protein Coding gene. Diseases associated with CHRM5 include cannabis dependence and schizophrenia. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and G-protein coupled acetylcholine receptor activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for CHRM5 Gene

  • The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Tocris Summary for CHRM5 Gene

  • Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists could prove useful in the research and treatment of a wide range of central nervous system diseases including Alzheimers and Parkinsons.

Gene Wiki entry for CHRM5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRM5 Gene

Genomics for CHRM5 Gene

Genomic Location for CHRM5 Gene

Start:
33,968,245 bp from pter
End:
34,067,457 bp from pter
Size:
99,213 bases
Orientation:
Plus strand

Genomic View for CHRM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRM5 Gene

Regulatory Elements for CHRM5 Gene

Proteins for CHRM5 Gene

  • Protein details for CHRM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08912-ACM5_HUMAN
    Recommended name:
    Muscarinic acetylcholine receptor M5
    Protein Accession:
    P08912
    Secondary Accessions:
    • Q96RG7

    Protein attributes for CHRM5 Gene

    Size:
    532 amino acids
    Molecular mass:
    60074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHRM5 Gene

Proteomics data for CHRM5 Gene at MOPED

Post-translational modifications for CHRM5 Gene

Other Protein References for CHRM5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHRM5 Gene

Domains for CHRM5 Gene

Gene Families for CHRM5 Gene

HGNC:
  • CHR :Cholinergic receptors
  • CHRM :GPCR / Class A : Cholinergic receptors, muscarinic
IUPHAR :

UniProtKB/Swiss-Prot:

ACM5_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.:
    • P08912
genes like me logo Genes that share domains with CHRM5: view

Function for CHRM5 Gene

Molecular function for CHRM5 Gene

GENATLAS Biochemistry: cholinergic receptor,muscarinic 5,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Gene Ontology (GO) - Molecular Function for CHRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 1905013
GO:0004930 G-protein coupled receptor activity --
GO:0016907 G-protein coupled acetylcholine receptor activity IEA --
genes like me logo Genes that share ontologies with CHRM5: view
genes like me logo Genes that share phenotypes with CHRM5: view

Animal Models for CHRM5 Gene

MGI Knock Outs for CHRM5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CHRM5 Gene

Localization for CHRM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRM5 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRM5 Gene COMPARTMENTS Subcellular localization image for CHRM5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CHRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
GO:0045202 synapse IBA --
genes like me logo Genes that share ontologies with CHRM5: view

Pathways for CHRM5 Gene

genes like me logo Genes that share pathways with CHRM5: view

Gene Ontology (GO) - Biological Process for CHRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001696 gastric acid secretion IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway TAS 8663391
GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA --
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway TAS 3272174
genes like me logo Genes that share ontologies with CHRM5: view

Compounds for CHRM5 Gene

(2) Tocris Compounds for CHRM5 Gene

Compound Action Cas Number
VU 0238429 Selective positive allosteric modulator of M5 receptors [1160247-92-6]
VU 0365114 Positive allosteric modulator of M5 receptors [1208222-39-2]

(1) HMDB Compounds for CHRM5 Gene

Compound Synonyms Cas Number PubMed IDs
Olanzapine
  • Lanzac
132539-06-1

(31) Drugbank Compounds for CHRM5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aclidinium
  • 14115700
320345-99-1 target antagonist
Amitriptyline
  • Amitriprolidine
50-48-6 target antagonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist
Atropine
  • Atropin [German]
51-55-8 target antagonist
Benzquinamide
63-12-7 target antagonist

(37) IUPHAR Ligand for CHRM5 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]QNB None None 10.7
atropine Antagonist Antagonist 9.7
[3H]N-methyl scopolamine Antagonist Antagonist 9.7
4-DAMP Antagonist Antagonist 9
ipratropium Antagonist Antagonist 8.8
silahexocyclium Antagonist Antagonist 8.7
darifenacin Antagonist Antagonist 8.6
hexocyclium Antagonist Antagonist 8.4
NNC 11-1585 Agonist Full agonist 8.3
NNC 11-1607 Agonist Full agonist 8.2
NNC 11-1314 Agonist Full agonist 7.8
methoctramine Antagonist Antagonist 7.2
HHSiD Antagonist Antagonist 7.2
sabcomeline Agonist Partial agonist 7.1
hexahydrodifenidol Antagonist Antagonist 7.1
pirenzepine Antagonist Antagonist 6.9
himbacine Antagonist Antagonist 6.5
p-F-HHSiD Antagonist Antagonist 6.3
AFDX384 Antagonist Antagonist 6.3
acetylcholine Agonist Full agonist 6.1
MT3 Antagonist Antagonist 6
xanomeline Agonist Full agonist 5.9
AF-DX 116 Antagonist Antagonist 5.6
VU0255035 Antagonist Antagonist 5.6
(+)aceclidine Agonist Full agonist 5.5
milameline Agonist Partial agonist 5.4
lithocholylcholine Antagonist Antagonist 5.2
(-)aceclidine Agonist Partial agonist 5.1
pilocarpine Agonist Partial agonist 5
MT7 Antagonist Antagonist 5
carbachol Agonist Full agonist 4.9
McN-A-343 Agonist Partial agonist 4.9
N-chloromethyl-brucine Allosteric regulator Negative 4.4
N-benzyl brucine Allosteric regulator Neutral 3.7
brucine Allosteric regulator Negative 2.9
brucine N-oxide Allosteric regulator Positive 2.3
strychnine Antagonist Antagonist

(3) Novoseek inferred chemical compound relationships for CHRM5 Gene

Compound -log(P) Hits PubMed IDs
carbachol 59.3 2
calcium 16.6 1
dopamine 14.7 1
genes like me logo Genes that share compounds with CHRM5: view

Transcripts for CHRM5 Gene

mRNA/cDNA for CHRM5 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHRM5 Gene

Cholinergic receptor, muscarinic 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHRM5 Gene

No ASD Table

Relevant External Links for CHRM5 Gene

GeneLoc Exon Structure for
CHRM5
ECgene alternative splicing isoforms for
CHRM5

Expression for CHRM5 Gene

mRNA expression in normal human tissues for CHRM5 Gene

mRNA differential expression in normal tissues according to GTEx for CHRM5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (16.2), Brain - Substantia nigra (6.2), and Brain - Hypothalamus (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHRM5 Gene

SOURCE GeneReport for Unigene cluster for CHRM5 Gene Hs.584747

genes like me logo Genes that share expressions with CHRM5: view

Orthologs for CHRM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRM5 36
  • 99.37 (n)
  • 99.44 (a)
CHRM5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHRM5 36
  • 90.23 (n)
  • 90.79 (a)
CHRM5 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRM5 36
  • 90.29 (n)
  • 88.91 (a)
CHRM5 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrm5 36
  • 88.16 (n)
  • 88.72 (a)
Chrm5 16
Chrm5 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHRM5 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrm5 36
  • 88.45 (n)
  • 88.89 (a)
chicken
(Gallus gallus)
Aves CHRM5 36
  • 72.5 (n)
  • 77.38 (a)
CHRM5 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHRM5 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chrm5 36
  • 70.25 (n)
  • 73 (a)
zebrafish
(Danio rerio)
Actinopterygii chrm5a 36
  • 64.28 (n)
  • 65.94 (a)
chrm5a 37
  • 63 (a)
OneToMany
chrm5b 37
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mAcR-60C 37
  • 25 (a)
OneToMany
mAcR-60C 38
  • 56 (a)
CG7918 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea gar-3 37
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToMany
Species with no ortholog for CHRM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRM5 Gene

ENSEMBL:
Gene Tree for CHRM5 (if available)
TreeFam:
Gene Tree for CHRM5 (if available)

Paralogs for CHRM5 Gene

Paralogs for CHRM5 Gene

Selected SIMAP similar genes for CHRM5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHRM5: view

Variants for CHRM5 Gene

Sequence variations from dbSNP and Humsavar for CHRM5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs486845 -- 34,047,616(-) cagag(A/G)taaca intron-variant
rs499167 -- 34,056,137(-) ATTCT(G/T)AACTA intron-variant
rs513706 -- 34,046,938(-) ctcct(G/T)ttcca intron-variant
rs519774 -- 34,052,901(-) tttca(C/T)gatat intron-variant
rs522397 -- 34,058,712(-) GAATT(C/T)GGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHRM5 Gene

Variant ID Type Subtype PubMed ID
esv33337 CNV Gain+Loss 17666407
nsv456789 CNV Gain 19166990
nsv471235 CNV Gain 18288195
nsv456790 CNV Loss 19166990
dgv310n27 CNV Loss 19166990
nsv516347 CNV Loss 19592680
nsv903985 CNV Loss 21882294

Relevant External Links for CHRM5 Gene

HapMap Linkage Disequilibrium report
CHRM5

Disorders for CHRM5 Gene

(1) University of Copenhagen DISEASES for CHRM5 Gene

(1) Novoseek inferred disease relationships for CHRM5 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 17.5 1

Relevant External Links for CHRM5

Genetic Association Database (GAD)
CHRM5
Human Genome Epidemiology (HuGE) Navigator
CHRM5
genes like me logo Genes that share disorders with CHRM5: view

No data available for UniProtKB/Swiss-Prot for CHRM5 Gene

Publications for CHRM5 Gene

  1. Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2. (PMID: 8663391) Kohn E.C. … Felder C.C. (J. Biol. Chem. 1996) 3 23
  2. Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses. (PMID: 12675126) Fujii T. … Kawashima K. (Neurochem. Res. 2003) 3 23
  3. Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia. (PMID: 15292665) De Luca V. … Kennedy J.L. (Neuropsychobiology 2004) 3 23
  4. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. (PMID: 3272174) Bonner T.I. … Buckley N.J. (Neuron 1988) 3 4
  5. No evidence for association between 19 cholinergic genes and bipolar disorder. (PMID: 17373692) Shi J. … Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 49

Products for CHRM5 Gene

Sources for CHRM5 Gene

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