Aliases for CHRM5 Gene
External Ids for CHRM5 Gene
Previous GeneCards Identifiers for CHRM5 Gene
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHRM5 Gene
CHRM5 (Cholinergic Receptor, Muscarinic 5) is a Protein Coding gene. Diseases associated with CHRM5 include cannabis dependence and schizophrenia. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and G-protein coupled acetylcholine receptor activity. An important paralog of this gene is CHRM4.
UniProtKB/Swiss-Prot for CHRM5 Gene
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover
Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists could prove useful in the research and treatment of a wide range of central nervous system diseases including Alzheimer's and Parkinson's.