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Aliases for CHRM5 Gene

Aliases for CHRM5 Gene

  • Cholinergic Receptor, Muscarinic 5 2 3
  • Acetylcholine Receptor, Muscarinic 5 3
  • Acetylcholine Receptor 2
  • Muscarinic 5 2
  • HM5 3

External Ids for CHRM5 Gene

Previous GeneCards Identifiers for CHRM5 Gene

  • GC15P029591
  • GC15P027026
  • GC15P031889
  • GC15P032070
  • GC15P031977
  • GC15P032097
  • GC15P032048
  • GC15P034261
  • GC15P011124

Summaries for CHRM5 Gene

Entrez Gene Summary for CHRM5 Gene

  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHRM5 Gene

CHRM5 (Cholinergic Receptor, Muscarinic 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled acetylcholine receptor activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for CHRM5 Gene

  • The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Tocris Summary for CHRM5 Gene

  • Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1 - M5).They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects.

Gene Wiki entry for CHRM5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRM5 Gene

Genomics for CHRM5 Gene

Regulatory Elements for CHRM5 Gene

Genomic Location for CHRM5 Gene

Chromosome:
15
Start:
33,968,245 bp from pter
End:
34,067,457 bp from pter
Size:
99,213 bases
Orientation:
Plus strand

Genomic View for CHRM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CHRM5 Gene

Proteins for CHRM5 Gene

  • Protein details for CHRM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08912-ACM5_HUMAN
    Recommended name:
    Muscarinic acetylcholine receptor M5
    Protein Accession:
    P08912
    Secondary Accessions:
    • Q96RG7

    Protein attributes for CHRM5 Gene

    Size:
    532 amino acids
    Molecular mass:
    60074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHRM5 Gene

Proteomics data for CHRM5 Gene at MOPED

Post-translational modifications for CHRM5 Gene

  • Glycosylation at Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHRM5 Gene

Domains & Families for CHRM5 Gene

Gene Families for CHRM5 Gene

Suggested Antigen Peptide Sequences for CHRM5 Gene

Graphical View of Domain Structure for InterPro Entry

P08912

UniProtKB/Swiss-Prot:

ACM5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
genes like me logo Genes that share domains with CHRM5: view

Function for CHRM5 Gene

Molecular function for CHRM5 Gene

GENATLAS Biochemistry:
cholinergic receptor,muscarinic 5,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Gene Ontology (GO) - Molecular Function for CHRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 1905013
GO:0004930 G-protein coupled receptor activity --
GO:0016907 G-protein coupled acetylcholine receptor activity IEA --
genes like me logo Genes that share ontologies with CHRM5: view
genes like me logo Genes that share phenotypes with CHRM5: view

Animal Models for CHRM5 Gene

MGI Knock Outs for CHRM5:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CHRM5 Gene

Localization for CHRM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRM5 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRM5 Gene COMPARTMENTS Subcellular localization image for CHRM5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CHRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
GO:0045202 synapse IBA --
genes like me logo Genes that share ontologies with CHRM5: view

Pathways & Interactions for CHRM5 Gene

genes like me logo Genes that share pathways with CHRM5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001696 gastric acid secretion IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway TAS 8663391
GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA --
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway TAS 3272174
genes like me logo Genes that share ontologies with CHRM5: view

No data available for SIGNOR curated interactions for CHRM5 Gene

Drugs & Compounds for CHRM5 Gene

(97) Drugs for CHRM5 Gene - From: IUPHAR, DGIdb, DrugBank, NovoSeek, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atropine Approved Pharma Antagonist, antagonist, Target MAChRs antagonist 101
Darifenacin Approved, Investigational Pharma Antagonist, antagonist, Target 22
Doxepin Approved Pharma Antagonist, inhibitor, Target, antagonist 13
Homatropine Methylbromide Approved Pharma antagonist, Target Muscarinic AChR antagonist 0
Methotrimeprazine Approved Pharma Target, antagonist 6

(8) Additional Compounds for CHRM5 Gene - From: IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)aceclidine
Partial agonist, Agonist
(+)aceclidine
Full agonist, Agonist
AF-DX 116
Antagonist 102394-31-0
HHSiD
Antagonist
N-Dealkylated tolterodine
genes like me logo Genes that share compounds with CHRM5: view

Transcripts for CHRM5 Gene

mRNA/cDNA for CHRM5 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHRM5 Gene

Cholinergic receptor, muscarinic 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRM5 Gene

No ASD Table

Relevant External Links for CHRM5 Gene

GeneLoc Exon Structure for
CHRM5
ECgene alternative splicing isoforms for
CHRM5

Expression for CHRM5 Gene

mRNA expression in normal human tissues for CHRM5 Gene

mRNA differential expression in normal tissues according to GTEx for CHRM5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.2), Brain - Substantia nigra (x6.2), and Brain - Hypothalamus (x5.1).

Protein differential expression in normal tissues from HIPED for CHRM5 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRM5 Gene



SOURCE GeneReport for Unigene cluster for CHRM5 Gene Hs.584747

genes like me logo Genes that share expression patterns with CHRM5: view

Protein tissue co-expression partners for CHRM5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CHRM5 Gene

Orthologs for CHRM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRM5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHRM5 35
  • 90.23 (n)
  • 90.79 (a)
CHRM5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRM5 35
  • 90.29 (n)
  • 88.91 (a)
CHRM5 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrm5 35
  • 88.16 (n)
  • 88.72 (a)
Chrm5 16
Chrm5 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHRM5 35
  • 99.37 (n)
  • 99.44 (a)
CHRM5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrm5 35
  • 88.45 (n)
  • 88.89 (a)
oppossum
(Monodelphis domestica)
Mammalia CHRM5 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHRM5 35
  • 72.5 (n)
  • 77.38 (a)
CHRM5 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHRM5 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chrm5 35
  • 70.25 (n)
  • 73 (a)
zebrafish
(Danio rerio)
Actinopterygii chrm5a 35
  • 64.28 (n)
  • 65.94 (a)
chrm5a 36
  • 63 (a)
OneToMany
chrm5b 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7918 37
  • 35 (a)
mAcR-60C 37
  • 56 (a)
mAcR-60C 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gar-3 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for CHRM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRM5 Gene

ENSEMBL:
Gene Tree for CHRM5 (if available)
TreeFam:
Gene Tree for CHRM5 (if available)

Paralogs for CHRM5 Gene

Paralogs for CHRM5 Gene

(8) SIMAP similar genes for CHRM5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHRM5: view

Variants for CHRM5 Gene

Structural Variations from Database of Genomic Variants (DGV) for CHRM5 Gene

Variant ID Type Subtype PubMed ID
esv33337 CNV Gain+Loss 17666407
nsv456789 CNV Gain 19166990
nsv471235 CNV Gain 18288195
nsv456790 CNV Loss 19166990
dgv310n27 CNV Loss 19166990
nsv516347 CNV Loss 19592680
nsv903985 CNV Loss 21882294

Variation tolerance for CHRM5 Gene

Residual Variation Intolerance Score: 28.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRM5 Gene

HapMap Linkage Disequilibrium report
CHRM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CHRM5 Gene

Disorders for CHRM5 Gene

Relevant External Links for CHRM5

Genetic Association Database (GAD)
CHRM5
Human Genome Epidemiology (HuGE) Navigator
CHRM5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRM5
genes like me logo Genes that share disorders with CHRM5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRM5 Gene

Publications for CHRM5 Gene

  1. Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa. (PMID: 19029429) Mansfield K.J. … Burcher E. (J. Pharmacol. Exp. Ther. 2009) 25 26
  2. Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. (PMID: 17848919) Nasrallah H.A. (Mol. Psychiatry 2008) 25 26
  3. Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice. (PMID: 17310388) Thomsen M. … Caine S.B. (Psychopharmacology (Berl.) 2007) 23 67
  4. Muscarinic acetylcholine receptor subtypes in human corneal epithelium and endothelium. (PMID: 16506072) Grueb M. … Bartz-Schmidt K.U. (Graefes Arch. Clin. Exp. Ophthalmol. 2006) 23 67
  5. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26

Products for CHRM5 Gene

Sources for CHRM5 Gene

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