CHRM5 Gene
protein-coding GIFtS: 61
GCID: GC15P034261
|
|
cholinergic receptor, muscarinic 5
| |
Aliases
for CHRM5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cholinergic Receptor, Muscarinic 51 2 | | HM52 | | Acetylcholine Receptor, Muscarinic 52 | | Muscarinic Acetylcholine Receptor M52 |
Export aliases for CHRM5 gene to outside databasesPrevious GC identifers: GC15P029591 GC15P027026 GC15P031889 GC15P032070 GC15P031977 GC15P032097 GC15P032048 GC15P011124 |
Summaries
for CHRM5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHRM5:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversityof these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylatecyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influencemany effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptorare unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: ACM5_HUMAN, P08912Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylatecyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primarytransducing effect is Pi turnover
 summary
for CHRM5: Muscarinic receptors are widely distributed throughout the body and control distinct functions according to
location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous
system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists
could prove useful in the research and treatment of a wide range of central nervous system diseases
including Alzheimer's and Parkinson's.
Gene Wiki entry for CHRM5 (Muscarinic acetylcholine receptor M5)
|
Genomic Views
for CHRM5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHRM5 gene promoter:
TBP CUTL1 FOXC1 Nkx6-1 POU2F1 TFIID FOXJ2 (long isoform) Cart-1 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHRM5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRM5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q26 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q26CHRM5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P034261: view genomic region
(about GC identifiers)
Start:
|
34,260,921 bp from pter |
End:
|
34,357,291 bp from pter |
Size:
|
96,371 bases |
Orientation:
|
plus strand |
|
Proteins
for CHRM5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACM5_HUMAN, P08912 (See
protein sequence)Recommended Name: Muscarinic acetylcholine receptor M5 Size: 532 amino acids; 60074 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane;Multi-pass membrane protein
Secondary accessions: Q96RG7Explore the universe of human proteins at neXtProt for CHRM5: NX_P08912
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P08912
CHRM5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036257.1
ENSEMBL proteins: ENSP00000452742 ENSP00000372750 ENSP00000453745 Reactome Protein details: P08912
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CHRM5 for ontologies About GeneDecksing
CHRM5 Antibody Products:
Assay Products for CHRM5: |
Protein
Domains /
Families
for CHRM5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHRM5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P08912ProtoNet protein and cluster: P08912 2 Blocks protein families: IPB000502 Muscarinic M5 receptor signature IPB000995 Muscarinic acetylcholine receptor signature
UniProtKB/Swiss-Prot: ACM5_HUMAN, P08912Similarity: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5sub-subfamily |
Function
for CHRM5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ACM5_HUMAN, P08912Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylatecyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primarytransducing effect is Pi turnover Genatlas biochemistry entry for CHRM5:cholinergic receptor,muscarinic 5,G protein coupled receptor superfamily
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for CHRM5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004435 | phosphatidylinositol phospholipase C activity |
TAS | 1905013 | | GO:0016907 | G-protein coupled acetylcholine receptor activity |
IEA | -- |
CHRM5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CHRM5:
Animal Models:
Mouse knock-outs for CHRM5: Chrm5tm1Jwe Chrm5tm1.1Anis Chrm5tm1Yeo Chrm5tm1Minm
8 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Chrm5):
CHRM5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CHRM5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | Regulation of Actin Cytoskeleton | | | 5 | Monoamine GPCRs | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4  BioSystems Pathways for CHRM5
5/9 
Reactome Pathways for CHRM5 (see all 9)
4 
Kegg Pathways (Kegg details for CHRM5):
CHRM5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHRM5
3 Interacting proteins for CHRM5 (P089123) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
CHRM5 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHRM5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CHRM5 for compounds About GeneDecksing
Compounds for CHRM5 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| VU 0365114 | Positive allosteric modulator of M5 receptors | [1208222-39-2] | | VU 0238429 | Selective positive allosteric modulator of M5 receptors | -- |
1 HMDB Compound for CHRM5 About this table
10/30 DrugBank Compounds for CHRM5 (see all 30) About this table
3 Novoseek chemical compound relationships for CHRM5 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carbachol |
59.3 |
3 |
9368034 (1), 1921986 (1) |
| calcium |
16.6 |
1 |
9368034 (1) |
| dopamine |
14.7 |
1 |
15292665 (1) |
Search CenterWatch for drugs/clinical trials and news about CHRM5 / ACM5
|
Transcripts
for CHRM5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHRM5 gene: NM_012125.3 Unigene Cluster for CHRM5: Cholinergic receptor, muscarinic 5 Hs.584747 [show with all ESTs]Unigene Representative Sequence: NM_0121253 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000560035 ENST00000383263(uc001zhk.1) ENST00000557872(uc001zhl.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHRM5 (NM_012125) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHRM5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM5 |
Additional cDNA sequence: AB084282.1 AF026263.1 AF385591.1 AF498919.1 AK095198.1 BC041805.1 BC068528.1 3 DOTS entries: DT.97798437 DT.95258773 DT.121033193 14 AceView cDNA sequences: NM_012125 AF498919 AF026263 AK095198 BC041805 CB994866 BX102692 AB084282 CB565878 AF385591 AI088488 BI562468 BC068528 AL548447
GeneLoc Exon Structure
|
Expression
for CHRM5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHRM5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGATCTCCA
About this image
See CHRM5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHRM5
SOURCE GeneReport for Unigene cluster: Hs.584747
SABiosciences Expression via Pathway-Focused PCR Arrays including CHRM5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRM5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHRM5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRM5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRM5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM5 |
Orthologs
for CHRM5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CHRM5 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CHRM51 |
cholinergic receptor, muscarinic 5 |
72.81(n)
77.76(a) |
|
428881 NM_001031550.1 NP_001026721.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CHRM56 |
-- |
72(a) |
1 ↔ 1 |
1(33661407-33662993) |
zebrafish
(Danio rerio) |
Actinopterygii |
chrm5a1 |
cholinergic receptor, muscarinic 5a |
62.92(n)
65.01(a) |
|
553978 NM_001020803.1 NP_001018639.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mAcR-60C3 |
acetyl choline receptor signaling,
muscarinic more |
56(a)
(best of 2) |
|
60C7 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
gar-36 |
Muscarinic acetylcholine receptor gar-3 |
26(a) |
1 → many |
V(14564737-14579704) |
ENSEMBL Gene Tree for CHRM5 (if available)
TreeFam Gene Tree for CHRM5 (if available) |
Paralogs
for CHRM5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHRM5 gene
- HRH42 HRH12 CHRM12 CHRM22 HRH32 CHRM42 CHRM32
8 SIMAP similar genes for CHRM5 using alignment to 4 protein entries: ACM5_HUMAN (see all proteins):CHRM3 DRD2 HRH3 hA2aR ADRB2 CHRM1
CHRM2 CHRM4
CHRM5 for paralogs About GeneDecksing
|
Genomic Variants
for CHRM5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHRM5 (34260921 - 34357291 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CHRM5
3 CNVs: 53263 49527 7058 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHRM5 |
|
Disorders
/ Diseases
for CHRM5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHRM5 for disorders About GeneDecksing
OMIM gene information: 118496
OMIM disorders: --
9  diseases for CHRM5: About MalaCardscentral nervous system disease nervous system disease autism spectrum disorder schizophrenia
pharyngitis retinoblastoma melanoma neuronitis
drug addiction
1 disease from the University of Copenhagen DISEASES database for CHRM5:Cannabis dependence 1 Novoseek disease relationship for CHRM5 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| schizophrenia |
17.5 |
1 |
15292665 (1) |
Human Genome Epidemiology (HuGE) Navigator: CHRM5 (12 documents)
Export disorders for CHRM5 gene to outside databases
|
Publications
for CHRM5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHRM5 gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with CHRM5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. (PubMed id 3272174)1, 2 Bonner T.I.... Buckley N.J. (1988)
- Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia. (PubMed id 15292665)1, 9 De Luca V....Kennedy J.L. (2004)
- Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses. (PubMed id 12675126)1, 9 Fujii T....Kawashima K. (2003)
- Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2. (PubMed id 8663391)1, 9 Kohn E.C....Felder C.C. (1996)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1 Need A.C....Goldstein D.B. (2009)
- A pilot multivariate parallel ICA study to investigat e differential linkage between neural networks and genetic profiles in schizoph renia. (PubMed id 19944766)1 Meda S.A....Pearlson G.D. (2009)
- Comparison of receptor binding characteristics of com monly used muscarinic antagonists in human bladder detrusor and mucosa. (PubMed id 19029429)7 Mansfield K.J....Burcher E. (2009)
- Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1 Tabakoff B....Hoffman P.L. (2009)
|
External Searches for CHRM5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHRM5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHRM5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHRM5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHRM5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CHRM5 gene:
Search GeneIP for patents involving CHRM5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHRM5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHRM5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHRM5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRM5 | | | OriGene Protein Over-expression Lysate for CHRM5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHRM5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHRM5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHRM5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRM5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRM5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRM5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRM5 |
| |
 |  |  |  | |
| | | | Tocris compounds for CHRM5 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CHRM5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM5 |
|  |  |  | | | | ThermoFisher Antibodies for CHRM5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM5 |
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