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CHRM5 Gene

protein-coding   GIFtS: 62
GCID: GC15P034261

Cholinergic Receptor, Muscarinic 5

  See CHRM5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cholinergic Receptor, Muscarinic 51 2
Acetylcholine Receptor1
Muscarinic 51
HM52
Acetylcholine Receptor, Muscarinic 52
Muscarinic Acetylcholine Receptor M52

External Ids:    HGNC: 19541   Entrez Gene: 11332   Ensembl: ENSG000001849847   OMIM: 1184965   UniProtKB: P089123   

Export aliases for CHRM5 gene to outside databases

Previous GC identifers: GC15P029591 GC15P027026 GC15P031889 GC15P032070 GC15P031977 GC15P032097 GC15P032048 GC15P011124


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHRM5 Gene:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional
diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as
adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic
receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical
implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP
levels. (provided by RefSeq, Jul 2008)

GeneCards Summary for CHRM5 Gene:
CHRM5 (cholinergic receptor, muscarinic 5) is a protein-coding gene. Diseases associated with CHRM5 include cannabis dependence, and schizophrenia. GO annotations related to this gene include G-protein coupled acetylcholine receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: ACM5_HUMAN, P08912
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of
adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G
proteins. Primary transducing effect is Pi turnover

summary for CHRM5 Gene:
Muscarinic receptors are widely distributed throughout the body and control distinct functions according to
location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous
system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists
could prove useful in the research and treatment of a wide range of central nervous system diseases
including Alzheimer's and Parkinson's.

Gene Wiki entry for CHRM5 (Muscarinic acetylcholine receptor M5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHRM5 gene promoter:
         TBP   CUTL1   FOXC1   Nkx6-1   POU2F1   TFIID   FOXJ2 (long isoform)   Cart-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRM5 promoter sequence
   Search Chromatin IP Primers for CHRM5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q26

CHRM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRM5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P034261:  view genomic region     (about GC identifiers)

Start:
34,260,921 bp from pter      End:
34,357,291 bp from pter
Size:
96,371 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ACM5_HUMAN, P08912 (See protein sequence)
Recommended Name: Muscarinic acetylcholine receptor M5  
Size: 532 amino acids; 60074 Da
Secondary accessions: Q96RG7

Explore the universe of human proteins at neXtProt for CHRM5: NX_P08912

Explore proteomics data for CHRM5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8

  • See CHRM5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036257.1  
    ENSEMBL proteins: 
     ENSP00000452742   ENSP00000372750   ENSP00000453745  
    Reactome Protein details: P08912

    CHRM5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CHRM5

     
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    antibodies-online proteins for CHRM5 (3 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHRM: GPCR / Class A : Cholinergic receptors, muscarinic
    CHR: Cholinergic receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: M5 receptor
    Acetylcholine receptors (muscarinic)

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000502 Musac_Ach_M5_rcpt
     IPR000995 Musac_Ach_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P08912

    ProtoNet protein and cluster: P08912

    2 Blocks protein domains:
    IPB000502 Muscarinic M5 receptor signature
    IPB000995 Muscarinic acetylcholine receptor signature


    UniProtKB/Swiss-Prot: ACM5_HUMAN, P08912
    Similarity: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5
    sub-subfamily


    Find genes that share domains with CHRM5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACM5_HUMAN, P08912
    Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of
    adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G
    proteins. Primary transducing effect is Pi turnover

         Genatlas biochemistry entry for CHRM5:
    cholinergic receptor,muscarinic 5,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS1905013
    GO:0004930G-protein coupled receptor activity ----
    GO:0016907G-protein coupled acetylcholine receptor activity IEA--
         
    Find genes that share ontologies with CHRM5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CHRM5:
     Decreased nuclei size in G2M 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Chrm5):
     behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism 
     muscle  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with CHRM5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CHRM5: Chrm5tm1Jwe Chrm5tm1.1Anis Chrm5tm1Yeo Chrm5tm1Minm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHRM5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHRM5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHRM5
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    hsa-miR-92a hsa-miR-363 hsa-miR-25 hsa-miR-367 hsa-miR-1208 hsa-miR-32 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidCHRM5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CHRM5

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    GenScript: all cDNA clones in your preferred vector: CHRM5 (NM_012125)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACM5_HUMAN, P08912: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    Find genes that share ontologies with CHRM5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHRM5 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Muscarinic acetylcholine receptors0.00
    Amine ligand-binding receptors0.79
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90


    Find genes that share SuperPaths with CHRM5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for CHRM5
        Calcium Regulation in the Cardiac Cell
    Regulation of Actin Cytoskeleton
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for CHRM5
        G alpha (q) signalling events
    Muscarinic acetylcholine receptors


    4 Kegg Pathways  (Kegg details for CHRM5):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Cholinergic synapse
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CHRM5: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CHRM5

    3 Interacting proteins for CHRM5 (P089123) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPRASP1Q5JY773I2D: score=2 
    AP3M1Q9Y2T23I2D: score=1 
    SNX1Q135963I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001696gastric acid secretion IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007197adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway TAS8663391
    GO:0007213G-protein coupled acetylcholine receptor signaling pathway TAS3272174
    GO:0008152metabolic process TAS1905013

    Find genes that share ontologies with CHRM5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CHRM5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    VU 0365114Positive allosteric modulator of M5 receptors[1208222-39-2]
    VU 0238429Selective positive allosteric modulator of M5 receptors[1160247-92-6]

    1 HMDB Compound for CHRM5    About this table
    CompoundSynonyms CAS #PubMed Ids
    OlanzapineLanzac (see all 5)132539-06-1--

    Selected DrugBank Compounds for CHRM5 (see all 31)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AtropineAtropin [German] (see all 5)51-55-8targetantagonist7855217 17139284 11752352 17016423
    Doxepin-- 1668-19-5targetantagonist2141000 7855217 2329499
    Homatropine Methylbromide-- 80-49-9targetantagonist17139284 11752352 17016423
    MaprotilineMaprotilina [INN-Spanish] (see all 4)10262-69-8targetantagonist7052344 6118411 6297650
    MetixeneMethixen [German] (see all 7)4969-02-2targetantagonist17139284 11752352 17016423
    PromazinePromazin (see all 2)58-40-2targetantagonist17139284 11752352 17016423
    Benzquinamide-- 63-12-7targetantagonist17139284 17016423
    Cryptenamine-- 1356-18-9targetantagonist17139284 17016423
    Darifenacin-- 133099-04-4targetantagonist18046909 10374898
    Methotrimeprazine-- 60-99-1targetantagonist2870716 2899826

    Selected IUPHAR Ligands for CHRM5 (M5 receptor) (see all 37)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]QNB
    NoneNone10.22 - 10.7--
    atropine
    AntagonistAntagonist9.3 - 9.72704370 11303071
    [3H]N-methyl scopolamine
    AntagonistAntagonist8.1 - 9.79846649 7687290 11303071 16369696 12235229 7925952
    4-DAMP
    AntagonistAntagonist91994002
    ipratropium
    AntagonistAntagonist8.811303071
    silahexocyclium
    AntagonistAntagonist8.72704370
    darifenacin
    AntagonistAntagonist8.611303071
    hexocyclium
    AntagonistAntagonist8.42704370
    NNC 11-1585
    AgonistFull agonist8.311504829
    NNC 11-1607
    AgonistFull agonist8.211504829

    3 Novoseek inferred chemical compound relationships for CHRM5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbachol 59.3 3 9368034 (1), 1921986 (1)
    calcium 16.6 1 9368034 (1)
    dopamine 14.7 1 15292665 (1)



    Find genes that share compounds with CHRM5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHRM5 gene: 
    NM_012125.3  

    Unigene Cluster for CHRM5:

    Cholinergic receptor, muscarinic 5
    Hs.584747  [show with all ESTs]
    Unigene Representative Sequence: NM_012125
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560035 ENST00000383263(uc001zhk.1) ENST00000557872(uc001zhl.1)

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      QuantiFast Probe-based Assays in human, mouse, rat CHRM5

    Additional mRNA sequence: 

    AB084282.1 AF026263.1 AF385591.1 AF498919.1 AK095198.1 BC041805.1 BC068528.1 

    3 DOTS entries:

    DT.97798437  DT.95258773  DT.121033193 

    14 AceView cDNA sequences:

    AK095198 AF498919 NM_012125 AF026263 CB565878 BI562468 CB994866 AB084282 
    AF385591 BC041805 AI088488 BC068528 BX102692 AL548447 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHRM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGATCTCCA
    CHRM5 Expression
    About this image

    CHRM5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHRM5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584747
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CHRM5: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHRM5
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    QuantiFast Probe-based Assays in human, mouse, rat CHRM5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHRM5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrm51 , 5 cholinergic receptor, muscarinic 51, 5 88.16(n)1
    88.72(a)1
      2 (57.02 cM)5
    2137881  NM_205783.21  NP_991352.21 
     1124791715 
    chicken
    (Gallus gallus)
    Aves CHRM51 cholinergic receptor, muscarinic 5 72.5(n)
    77.38(a)
      428881  NM_001031550.1  NP_001026721.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHRM56
    cholinergic receptor, muscarinic 5
    72(a)
    1 ↔ 1
    1(33661407-33662993)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia chrm51 cholinergic receptor, muscarinic 5 70.25(n)
    73(a)
      100498518  XM_002935341.2  XP_002935387.2 
    zebrafish
    (Danio rerio)
    Actinopterygii chrm5a1 cholinergic receptor, muscarinic 5a 64.28(n)
    65.94(a)
      553978  NM_001020803.1  NP_001018639.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mAcR-60C3 acetyl choline receptor signaling,
    muscarinic more
    56(a)
    (best of 2)
      60C7   --
    worm
    (Caenorhabditis elegans)
    Secernentea gar-36
    Protein GAR-3, isoform b (gar-3) mRNA, complete cd...
    29(a)
    1 → many
    V(14564752-14579719) WBGene00001519


    ENSEMBL Gene Tree for CHRM5 (if available)
    TreeFam Gene Tree for CHRM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHRM5 gene
    HTR2A2  DRD42  DRD22  CHRM12  CHRM22  HRH32  HTR2B2  HRH42  
    HTR2C2  HRH12  DRD32  CHRM42  CHRM32  
    8 SIMAP similar genes for CHRM5 using alignment to 4 protein entries:     ACM5_HUMAN (see all proteins):
    CHRM3    DRD2    HRH3    hA2aR    ADRB2    CHRM1
    CHRM2    CHRM4

    Find genes that share paralogs with CHRM5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHRM5 (see all 517)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882007631,2
    --34333313(+) GTAACA/GTTTTG 1 -- int10--------
    rs1473121221,2
    C--34333322(+) GTGGC-/GGGG  
            
    GGTAG
    1 -- int10--------
    rs1819748021,2
    --34333376(+) CTACCA/CACTAG 1 -- int10--------
    rs1875743161,2
    --34333411(+) CTCATG/TAAGAC 1 -- int10--------
    rs1379356731,2
    --34333460(+) AGAGGC/TAATCA 1 -- int10--------
    rs124432331,2
    H--34333468(+) tcaccC/Gtggat 1 -- int10--------
    rs762470531,2
    C,F--34333665(+) GGAAAT/CAGGGC 1 -- int12Minor allele frequency- C:0.07WA EA 238
    rs1899133291,2
    --34333935(+) TAAATA/CTTCAA 1 -- int10--------
    rs27023181,2
    H--34333989(-) gttttC/Tttatc 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs26849451,2
    H--34334113(+) CCTCAG/AAAGTC 1 -- int14Minor allele frequency- A:0.00NS EA 418

    HapMap Linkage Disequilibrium report for CHRM5 (34260921 - 34357291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CHRM5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv456790CNV Loss19166990
    nsv516347CNV Loss19592680
    dgv310n27CNV Loss19166990
    nsv903985CNV Loss21882294
    nsv456789CNV Gain19166990
    nsv471235CNV Gain18288195
    esv33337CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHRM5
    DNA2.0 Custom Variant and Variant Library Synthesis for CHRM5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118496    OMIM disorders: --

    2 diseases for CHRM5:    
    About MalaCards
    cannabis dependence    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for CHRM5:
    Cannabis dependence

    Find genes that share disorders with CHRM5           About GenesLikeMe

    1 Novoseek inferred disease relationship for CHRM5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 17.5 1 15292665 (1)

    Genetic Association Database (GAD): CHRM5
    Human Genome Epidemiology (HuGE) Navigator: CHRM5 (12 documents)

    Export disorders for CHRM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHRM5 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with CHRM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. (PubMed id 19944766)1, 4 Meda S.A....Pearlson G.D. (Neuroimage 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    7. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    8. No evidence for association between 19 cholinergic genes and bipolar disorder. (PubMed id 17373692)1, 4 Shi J....Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    9. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. (PubMed id 3272174)1, 2 Bonner T.I.... Buckley N.J. (Neuron 1988)
    10. Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia. (PubMed id 15292665)1, 9 De Luca V....Kennedy J.L. (Neuropsychobiology 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1133 HGNC: 1954 AceView: CHRM5 Ensembl:ENSG00000184984 euGenes: HUgn1133
    ECgene: CHRM5 Kegg: 1133 H-InvDB: CHRM5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHRM5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHRM5 gene:
    Search GeneIP for patents involving CHRM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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