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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CHRM4 Gene

protein-coding GIFtS: 62
GCID: GC11M046406

cholinergic receptor, muscarinic 4

Explore 9 diseases affiliated with
CHRM4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cholinergic Receptor, Muscarinic 4¹ ²
HM4²
M4R²
Acetylcholine Receptor, Muscarinic 4²
Muscarinic Acetylcholine Receptor M4²

External Ids:	HGNC: 1953¹	Entrez Gene: 1132²	Ensembl: ENSG00000180720⁷	OMIM: 118495⁵	UniProtKB: P08173³

Export aliases for CHRM4 gene to outside databases

Previous GC identifers: GC11M048191 GC11M047097 GC11M046438 GC11M046370 GC11M046363 GC11M046113

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHRM4:

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity

of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate

cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence

many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor

are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ACM4_HUMAN, P08173

Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate

cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary

transducing effect is inhibition of adenylate cyclase

summary for CHRM4:

Muscarinic receptors are widely distributed throughout the body and control distinct functions according to

location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous

system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists

could prove useful in the research and treatment of a wide range of central nervous system diseases

including Alzheimer's and Parkinson's.

Gene Wiki entry for CHRM4 (Muscarinic acetylcholine receptor M4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CHRM4 gene promoter:
NF-1 NF-1/L STAT3
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CHRM4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRM4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p12-p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p12-p11.2

CHRM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRM4 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M046406: view genomic region (about GC identifiers)

Start:	46,406,640 bp from pter	End:	46,408,107 bp from pter
Size:	1,468 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACM4_HUMAN, P08173 (See protein sequence)

Recommended Name: Muscarinic acetylcholine receptor M4

Size: 479 amino acids; 53049 Da

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane;

Multi-pass membrane protein

Secondary accessions: B2RPP4 Q0VD60 Q4VBK7

Explore the universe of human proteins at neXtProt for CHRM4: NX_P08173

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08173

CHRM4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000732.2

ENSEMBL proteins:

ENSP00000409378

Reactome Protein details: P08173
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CHRM4 Protein
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	Uscn Proteins for CHRM4

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	3037705
GO:0014069	postsynaptic density	--	--
GO:0030054	cell junction	IEA	--

CHRM4 for ontologies About GeneDecksing

CHRM4 Antibody Products:

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	ThermoFisher Antibodies for CHRM4

Assay Products for CHRM4:

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	GenScript CHRM4-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CHRM4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CHRM4 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR001432 Musac_M4_rcpt

IPR000995 Musac_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P08173

ProtoNet protein and cluster: P08173

2 Blocks protein families:

IPB000995 Muscarinic acetylcholine receptor signature

IPB001432 Muscarinic M4 receptor signature

UniProtKB/Swiss-Prot: ACM4_HUMAN, P08173

Similarity: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4

sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ACM4_HUMAN, P08173

Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate

cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary

transducing effect is inhibition of adenylate cyclase

Genatlas biochemistry entry for CHRM4:

cholinergic receptor,muscarinic 4,G protein coupled receptor superfamily

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHRM4
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CHRM4
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHRM4 (see all 7) OriGene shRNA RFP: CHRM4 OriGene siRNA: CHRM4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRM4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CHRM4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: CHRM4 (NM_000741)
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Cell Line Products:		GenScript CHRM4-overexpressing Cell Line for Assay
		Search LifeMap BioReagents cell lines for CHRM4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM4

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	--	--
GO:0005515	protein binding	--	--
GO:0016907	G-protein coupled acetylcholine receptor activity	IEA	--

CHRM4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CHRM4:

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-outs for CHRM4: Chrm4^tm1Jwe Chrm4^tm1Minm
8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Chrm4):

behavior/neurological	cardiovascular system	growth/size	homeostasis/metabolism	liver/biliary system
muscle	nervous system	no phenotypic analysis

CHRM4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Development Angiotensin activation of ERK

	Development_ACM2 and ACM4 activation of ERK	0.74			Cholinergic synapse	0.30
	Development ACM2 and ACM4 activation of ERK	0.74

Regulation of Actin Cytoskeleton

Regulation of Actin Cytoskeleton

1.00

Regulation of actin cytoskeleton

0.58

Monoamine GPCRs

Monoamine GPCRs

1.00

Amine ligand-binding receptors

0.79

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CHRM4

Development ACM2 and ACM4 activation of ERK

1 GeneGo (Thomson Reuters) Pathway for CHRM4

Development ACM2 and ACM4 activation of ERK

4 BioSystems Pathways for CHRM4

	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Regulation of Actin Cytoskeleton
	Monoamine GPCRs

5/8 Reactome Pathways for CHRM4 (see all 8)

	GPCR downstream signaling
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)
	Signal Transduction

3 Kegg Pathways (Kegg details for CHRM4):

	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeleton

CHRM4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CHRM4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/169 Interacting proteins for CHRM4 (P08173³ ENSP00000409378⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 169)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GPRASP1	Q5JY77³, ENSP00000355146⁴	I2D: score=2 STRING: ENSP00000355146
EEF1A2	Q05639³, ENSP00000217182⁴	I2D: score=2 STRING: ENSP00000217182
GRB2	P62993³, ENSP00000339007⁴	I2D: score=2 STRING: ENSP00000339007
CAMK2A	Q9UQM7³	I2D: score=2
SNX1	Q13596³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	9603968
GO:0007166	cell surface receptor signaling pathway	TAS	2739737
GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	IEA	--
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	TAS	3443095
GO:0008283	cell proliferation	TAS	2739737

CHRM4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CHRM4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for CHRM4

Compounds for CHRM4 available from Tocris Bioscience About this table

Compound	Action	CAS #
Tropicamide	Selective M4 muscarinic antagonist	[1508-75-4]
AF-DX 384	Potent M2/M4 antagonist	[118290-27-0]
PD 102807	Selective M4 antagonist	[23062-91-1]
Oxotremorine sesquifumarate	Muscarinic agonist	[17360-35-9]
VU 10010	Selective allosteric potentiator of M4 receptors	[633283-39-3]

1 HMDB Compound for CHRM4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Olanzapine	Lanzac (see all 5)	132539-06-1	--

10/34 DrugBank Compounds for CHRM4 (see all 34) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Procyclidine	Prociclidina [INN-Spanish] (see all 2)	77-37-2	target	antagonist	7616431 17139284 20624420 1426023 17016423 2253700
Tropicamide	--	1508-75-4	target	antagonist	17594079 17139284 11752352 17016423
Atropine	Atropin [German] (see all 5)	51-55-8	target	antagonist	7855217 17139284 17016423
Doxepin	Doxepin Hcl (see all 5)	1668-19-5	target	antagonist	2141000 7855217 2329499
Homatropine Methylbromide	--	80-49-9	target	antagonist	17139284 17016423 6893558
Maprotiline	Maprotilina [INN-Spanish] (see all 4)	10262-69-8	target	antagonist	7052344 6118411 6297650
Benzquinamide	--	63-12-7	target	antagonist	17139284 17016423
Cryptenamine	--	1356-18-9	target	antagonist	17139284 17016423
Darifenacin	--	133099-04-4	target	antagonist	10374898 18046909
Isopropamide	2,2-Diphenyl-4-diisopropylaminobutyramide methiodide (see all 5)	7492-32-2	target	antagonist	29133 3580704

3 Novoseek chemical compound relationships for CHRM4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acetylcholine	42.8	1	8305442 (1)
inositol 1,4,5 trisphosphate	35.8	1	7761266 (1)
calcium	7.62	1	7761266 (1)

Search CenterWatch for drugs/clinical trials and news about CHRM4 / ACM4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CHRM4 gene:

NM_000741.2

Unigene Cluster for CHRM4:

Cholinergic receptor, muscarinic 4

Hs.248100 [show with all ESTs]

Unigene Representative Sequence: BC137535

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000433765(uc001nct.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHRM4
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRM4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRM4

Additional cDNA sequence:

AF385590.1 AF498918.1 BC095546.1 BC119775.1 BC119817.1 BC137535.1

2 DOTS entries:

DT.100741087 DT.92025388

10 AceView cDNA sequences:

BF724332 AF498918 BU147486 NM_000741 BQ710852 BQ225197 CB565879 BQ322895

AF385590 BE251408

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CHRM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCTGGTGA

About this image

CHRM4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CHRM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHRM4

SOURCE GeneReport for Unigene cluster: Hs.248100

SABiosciences Expression via Pathway-Focused PCR Arrays including CHRM4:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRM4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRM4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CHRM4 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CHRM4¹	cholinergic receptor, muscarinic 4	75.93(n) 77.78(a)		423195 NM_001031191.1 NP_001026362.1
lizard (Anolis carolinensis)	Reptilia	CHRM4⁶	--	78(a)	1 ↔ 1	1(42632108-42633517)
zebrafish (Danio rerio)	Actinopterygii	chrm4a¹	cholinergic receptor, muscarinic 4a	71.21(n) 73.19(a)		100150701 XM_001922407.1 XP_001922442.1
fruit fly (Drosophila melanogaster)	Insecta	mAcR-60C³	acetyl choline receptor signaling, muscarinic pathway muscarinic acetylcholine receptor less	57(a) (best of 2)		60C7 --
worm (Caenorhabditis elegans)	Secernentea	gar-3⁶	Muscarinic acetylcholine receptor gar-3	26(a)	1 → many	V(14564737-14579704)

ENSEMBL Gene Tree for CHRM4 (if available)
TreeFam Gene Tree for CHRM4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CHRM4 gene

HRH4² CHRM5² HRH1² CHRM1² CHRM2² HRH3² CHRM3²

11 SIMAP similar genes for CHRM4 using alignment to 2 protein entries: ACM4_HUMAN (see all proteins):

CHRM2 CHRM1 hA2aR CHRM3 CHRM5 HTR5A

HRH3 DRD5P1 HRH1 5HT1A HTR1A

CHRM4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188978553^1,2		--	46406217(+)	`GGGGTA/GCAAGG`	1	--	ds500¹		0	--	--	--	--
rs140392370^1,2		--	46406332(+)	`CCTGGA/GCTTCG`	1	--	ds500¹		0	--	--	--	--
rs150308332^1,2		--	46406337(+)	`GCTTCA/GGCCCC`	1	--	ds500¹		0	--	--	--	--
rs137862710^1,2		--	46406426(+)	`AGCTCA/GCTGAA`	1	--	ds500¹		0	--	--	--	--
rs181377892^1,2		--	46406438(+)	`CAGGGC/TCACAG`	1	--	ds500¹		0	--	--	--	--
rs72910092^1,2	C,F,	--	46406493(+)	`CTCCTC/TAGCCT`	1	--	ds500¹		1		NA	120
rs186532285^1,2		--	46406496(+)	`CTCAGC/TCTGAG`	1	--	ds500¹		0	--	--	--	--
rs11823766^1,2	C,F,H	--	46406497(+)	`TCAGCC/TTGAGC`	1	--	ds500¹		8		NS EA NA	856
rs201311493^1,2	C,	--	46406645(+)	`CAGCAC/TCTCCT`	1	--	ut3¹		0	--	--	--	--
rs200267035^1,2	C	--	46406715(+)	`GTGCCA/GGAAGG`	2	R W	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CHRM4 (46406640 - 46408107 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHRM4: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CHRM4 for disorders           About GeneDecksing

OMIM gene information: 118495    OMIM disorders: --

9 diseases for CHRM4:    About MalaCards

central nervous system disease nervous system disease supranuclear palsy progressive supranuclear palsy

pharyngitis dementia neuroblastoma schizophrenia

neuronitis

Human Genome Epidemiology (HuGE) Navigator: CHRM4 (5 documents)

Export disorders for CHRM4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CHRM4 gene, integrated from 9 sources (see all 85):
(articles sorted by number of sources associating them with CHRM4)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic linkage mapping of the m4 human muscarinic receptor (CHRM4). (PubMed id 1577490)^{1, 3} Grewal R.P....Detera-Wadleigh S. (1992)
Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. (PubMed id 3272174)^{1, 2} Bonner T.I.... Buckley N.J. (1988)
Distinct primary structures, ligand-binding properties and tissue- specific expression of four human muscarinic acetylcholine receptors. (PubMed id 3443095)^{1, 2} Peralta E.G....Capon D.J. (1987)
Identification of a family of muscarinic acetylcholine receptor genes. (PubMed id 3037705)^{1, 2} Bonner T.I.... Brann M.R. (1987)
Muscarinic M4 receptor recycling requires a motif in the third intracellular loop. (PubMed id 18337477)^{1, 9} Hashimoto Y....Haga T. (2008)
Validating the use of M4-BAC-GFP mice as tissue donors in cell replacement therapies in a rodent model of Huntington's disease. (PubMed id 21295605)¹ Dobrossy M....Dunnett S.B. (2011)
Structural determinants of allosteric agonism and mod ulation at the M4 muscarinic acetylcholine receptor: identification of ligand-s pecific and global activation mechanisms. (PubMed id 20406819)¹ Nawaratne V....Christopoulos A. (2010)
Identification of neuronal target areas for nerve age nts and specification of receptors for pharmacological treatment. (PubMed id 20624420)⁷ Myhrer T. (2010)
Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)¹ Need A.C....Goldstein D.B. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1132	HGNC: 1953	AceView: CHRM4	Ensembl:ENSG00000180720	euGenes: HUgn1132
ECgene: CHRM4	Kegg: 1132	H-InvDB: CHRM4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CHRM4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CHRM4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CHRM4 gene:
Search GeneIP for patents involving CHRM4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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cholinergic receptor, muscarinic 4

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cholinergic receptor, muscarinic 4

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