Aliases for CHRM3 Gene
External Ids for CHRM3 Gene
Previous GeneCards Identifiers for CHRM3 Gene
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHRM3 Gene
CHRM3 (Cholinergic Receptor, Muscarinic 3) is a Protein Coding gene. Diseases associated with CHRM3 include eagle-barrett syndrome and cholinergic urticaria. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is CHRM4.
UniProtKB/Swiss-Prot for CHRM3 Gene
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists could prove useful in the research and treatment of a wide range of central nervous system diseases including Alzheimer's and Parkinson's.