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CHRM2 Gene

protein-coding   GIFtS: 70
GCID: GC07P136553

Cholinergic Receptor, Muscarinic 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cholinergic Receptor, Muscarinic 21 2     HM22
Acetylcholine Receptor1     Acetylcholine Receptor, Muscarinic 22
Muscarinic 21     Muscarinic Acetylcholine Receptor M22
7TM Receptor2     Muscarinic M2 Receptor2

External Ids:    HGNC: 19511   Entrez Gene: 11292   Ensembl: ENSG000001810727   OMIM: 1184935   UniProtKB: P081723   

Export aliases for CHRM2 gene to outside databases

Previous GC identifers: GC07M135039 GC07P135955 GC07P136115 GC07P136010 GC07P136203 GC07P130859


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHRM2 Gene:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional
diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular
responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation.
Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The
muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac
contractility. Multiple alternatively spliced transcript variants have been described for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CHRM2 Gene:
CHRM2 (cholinergic receptor, muscarinic 2) is a protein-coding gene. Diseases associated with CHRM2 include nervous system disease, and central nervous system disease. GO annotations related to this gene include G-protein coupled acetylcholine receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: ACM2_HUMAN, P08172
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of
adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G
proteins. Primary transducing effect is adenylate cyclase inhibition

summary for CHRM2 Gene:
Muscarinic receptors are widely distributed throughout the body and control distinct functions according to
location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous
system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists
could prove useful in the research and treatment of a wide range of central nervous system diseases
including Alzheimer's and Parkinson's.

Gene Wiki entry for CHRM2 (Muscarinic acetylcholine receptor M2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHRM2 gene promoter:
         FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CHRM2 promoter sequence
   Search Chromatin IP Primers for CHRM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31-q35   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q35-q36

CHRM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRM2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P136553:  view genomic region     (about GC identifiers)

Start:
136,553,399 bp from pter      End:
136,705,002 bp from pter
Size:
151,604 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 135,897,754-136,046,127     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACM2_HUMAN, P08172 (See protein sequence)
Recommended Name: Muscarinic acetylcholine receptor M2  
Size: 466 amino acids; 51715 Da
Subunit: Interacts with ARRB1 and ARRB2. Interacts with GNB2L1/RACK1; the interaction regulates CHRM2
internalization
4 PDB 3D structures from and Proteopedia for CHRM2:
1LUB (3D)        3UON (3D)        4MQS (3D)        4MQT (3D)    
Secondary accessions: Q4VBK6 Q9P1X9

Explore the universe of human proteins at neXtProt for CHRM2: NX_P08172

Explore proteomics data for CHRM2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn2, Asn3, Asn6, Asn9
  • Modification sites at PhosphoSitePlus

  • See CHRM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_000730.1  NP_001006627.1  NP_001006628.1  NP_001006629.1  NP_001006630.1  NP_001006631.1  NP_001006632.1  NP_001006633.1  

    ENSEMBL proteins: 
     ENSP00000399745   ENSP00000319984   ENSP00000415386   ENSP00000384401   ENSP00000380733  
     ENSP00000384937  
    Reactome Protein details: P08172

    CHRM2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CHRM2 Protein
    Browse R&D Systems for human recombinant proteins
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CHRM2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CHRM2
    GenScript Custom Purified and Recombinant Proteins Services for CHRM2
    Novus Biologicals CHRM2 Proteins
    Novus Biologicals CHRM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHRM2

    CHRM2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CHRM2
    R&D Systems Antibodies for CHRM2
    OriGene Antibodies for CHRM2
    OriGene Custom Antibody Services for CHRM2
    Novus Biologicals CHRM2 Antibodies
    Abcam antibodies for CHRM2
    Cloud-Clone Corp. Antibodies for CHRM2
    ThermoFisher Antibody for CHRM2
    LSBio Antibodies in human, mouse, rat for CHRM2

    CHRM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHRM2
    Browse R&D Systems for biochemical assays
    GenScript CHRM2-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHRM2
    Cloud-Clone Corp. CLIAs for CHRM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHRM: GPCR / Class A : Cholinergic receptors, muscarinic
    CHR: Cholinergic receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: M2 receptor
    Acetylcholine receptors (muscarinic)

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001065 Musac_Ach_M2_rcpt
     IPR000995 Musac_Ach_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P08172

    ProtoNet protein and cluster: P08172

    2 Blocks protein domains:
    IPB000995 Muscarinic acetylcholine receptor signature
    IPB001065 Muscarinic M2 receptor signature


    UniProtKB/Swiss-Prot: ACM2_HUMAN, P08172
    Similarity: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2
    sub-subfamily


    CHRM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACM2_HUMAN, P08172
    Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of
    adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G
    proteins. Primary transducing effect is adenylate cyclase inhibition
    Induction: Up-regulated in response to enterovirus 71 (EV71) infection

         Genatlas biochemistry entry for CHRM2:
    cholinergic receptor,muscarinic 2,G protein coupled receptor superfalily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0016907G-protein coupled acetylcholine receptor activity IEA--
         
    CHRM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHRM2:
     Increased cell number in G2M,  

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chrm2):
     behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism  integument 
     liver/biliary system  muscle  nervous system  renal/urinary system  respiratory system 
     vision/eye 

    CHRM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CHRM2: Chrm2tm1Jwe Chrm2tm1Minm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHRM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHRM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHRM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHRM2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHRM2:
    hsa-mir-335-5p (MIRT017560)

    Block miRNA regulation of human, mouse, rat CHRM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHRM2 (see all 30):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-3674 hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidCHRM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHRM2
    Predesigned siRNA for gene silencing in human, mouse, rat CHRM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHRM2

    Clone
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    OriGene clones in human, mouse for CHRM2 (see all 45)
    OriGene ORF clones in mouse, rat for CHRM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): CHRM2 (NM_001006626)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM2

    Cell Line
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    GenScript CHRM2-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHRM2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACM2_HUMAN, P08172: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    mitochondrion3
    extracellular1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    CHRM2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHRM2 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Muscarinic acetylcholine receptors0.00
    Amine ligand-binding receptors0.79
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Development Angiotensin activation of ERK
    Development ACM2 and ACM4 activation of ERK0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CHRM2
        Development ACM2 and ACM4 activation of ERK

    Selected BioSystems Pathways for CHRM2 (see all 7)
        SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    GPCRs, Other
    Regulation of Actin Cytoskeleton
    GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for CHRM2
        G alpha (i) signalling events
    Muscarinic acetylcholine receptors

    1 PharmGKB Pathway for CHRM2
        Antiarrhythmic Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for CHRM2):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway
    Cholinergic synapse
    Regulation of actin cytoskeleton


    CHRM2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CHRM2: 
              Neurogenesis in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CHRM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHRM2 (P081723 ENSP000003199844) via UniProtKB, MINT, STRING, and/or I2D (see all 176)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPRASP2Q96D093, ENSP000003390574I2D: score=3 STRING: ENSP00000339057
    GNA14O958373, ENSP000003658074I2D: score=1 STRING: ENSP00000365807
    GNA15P306793, ENSP000002629584I2D: score=1 STRING: ENSP00000262958
    GPRASP1Q5JY773, ENSP000003551464I2D: score=1 STRING: ENSP00000355146
    SETQ011053, ENSP000003617774I2D: score=1 STRING: ENSP00000361777
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9603968
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS10895079
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS8139539
    GO:0007207phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway TAS2739737
    GO:0007213G-protein coupled acetylcholine receptor signaling pathway ----

    CHRM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CHRM2
      Browse compounds at ApexBio 

    Compounds for CHRM2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (S)-(+)-Dimethindene maleateM2-selective antagonist[121367-05-3]
    Arecaidine but-2-ynyl ester tosylateMuscarinic agonist[499-04-7]
    AF-DX 384Potent M2/M4 antagonist[118290-27-0]
    AQ-RA 741 Selective, high affinity M2 antagonist [123548-16-3]
    AF-DX 116Selective M2 antagonist[102394-31-0]

    1 HMDB Compound for CHRM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    OlanzapineLanzac (see all 5)132539-06-1--

    Selected DrugBank Compounds for CHRM2 (see all 61)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Gallamine TriethiodideBenzcurine Iodide (see all 9)65-29-2targetantagonist18305010 17944454 20083608 17588565 18552124 11752352 9007524 15937215 11426849 7522861
    DiphenidolDifenidol (see all 7)972-02-1targetantagonist12185001 8050463 1863523 10497897 10530931 9851542 9059856 9454790
    AtropineAtropin [German] (see all 5)51-55-8targetantagonist15333678 7855217 16188951 17087737 17588565 16248990
    ProcyclidineProciclidina [INN-Spanish] (see all 2)77-37-2targetantagonist2027917 17139284 20624420 1426023 17016423 2253700
    BethanecholAmidopropyldimethylbetaine (see all 7)674-38-4targetagonist16953191 17139284 17016423 11798291 17413603
    Carbachol-- 51-83-2targetagonist16181410 15333678 12505062 12948933 15485827
    FlavoxateFlavoxate HCI (see all 2)15301-69-6targetantagonist17139284 3247311 19002123 17016423 10858873
    Homatropine Methylbromide-- 80-49-9targetantagonist2612581 20085574 17139284 11124384 17016423
    OxybutyninOxibutinina [INN-Spanish] (see all 10)5633-20-5targetantagonist16188951 15963006 20590605 19446545 17222678
    Cryptenamine-- 1356-18-9targetantagonist5918523 5674398 17139284 17016423

    Selected IUPHAR Ligands for CHRM2 (M2 receptor) (see all 69)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]QNB
    AntagonistAntagonist10.1 - 10.63443095
    NNC 11-1585
    AgonistFull agonist10.111504829
    [3H]N-methyl scopolamine
    AntagonistAntagonist6.3 - 9.99846649 11303071 12235229 16675658 9224827 7651370 7925952 7687290 16369696
    [3H](-)MQNB
    AntagonistAntagonist9.69454790
    tripitramine
    AntagonistAntagonist9.67805774
    propantheline
    AntagonistAntagonist9.512049493
    atropine
    AntagonistAntagonist7.8 - 9.211303071 12235229 3443095 16188951 12049493 2704370 9454790
    dexetimide
    AntagonistAntagonist8.99454790
    ipratropium
    AntagonistAntagonist8.811303071
    [3H]AF DX-384
    AntagonistAntagonist8.71941609

    Selected Novoseek inferred chemical compound relationships for CHRM2 gene (see all 68)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methoctramine 86.7 7 1596672 (2), 7768300 (1), 7744887 (1), 7773550 (1) (see all 6)
    pfhhsid 86 2 2361166 (1)
    gallamine 83.9 8 9232691 (1), 17588565 (1), 17944454 (1), 15937215 (1) (see all 8)
    carbachol 81.6 16 7768300 (3), 16227319 (1), 18045877 (1), 9384504 (1) (see all 11)
    5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one 80.6 1 9214706 (1)
    pirenzepine 78.6 11 8008195 (1), 1825686 (1), 8549614 (1), 9059856 (1) (see all 9)
    hexahydrosiladifenidol 78.6 1 8549614 (1)
    6beta-acetoxynortropane 76.4 2 9622546 (1), 10375728 (1)
    himbacine 75.7 4 2401311 (1), 10712818 (1), 12628644 (1), 8564213 (1)
    atropine 70.8 4 8008195 (1), 9631949 (1), 7952627 (1), 15708029 (1)



    CHRM2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for CHRM2 gene (9 alternative transcripts): 
    NM_000739.2  NM_001006626.1  NM_001006627.1  NM_001006628.1  NM_001006629.1  NM_001006630.1  NM_001006631.1  NM_001006632.1  
    NM_001006633.1  

    Unigene Cluster for CHRM2:

    Cholinergic receptor, muscarinic 2
    Hs.535891  [show with all ESTs]
    Unigene Representative Sequence: AL832585
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445907(uc003vtf.1 uc003vtg.1) ENST00000471195 ENST00000481598
    ENST00000480591(uc003vth.1) ENST00000320658 ENST00000453373 ENST00000401861(uc003vti.1)
    ENST00000397608(uc003vtj.1 uc003vtl.1) ENST00000402486(uc003vtm.1 uc003vtk.1 uc003vtn.1 uc003vto.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHRM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHRM2 (see all 30):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-3674 hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidCHRM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHRM2
    Predesigned siRNA for gene silencing in human, mouse, rat CHRM2
    Clone
    Products:
         
    OriGene clones in human, mouse for CHRM2 (see all 45)
    OriGene ORF clones in mouse, rat for CHRM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): CHRM2 (NM_001006626)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM2
    Primer
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    OriGene qPCR primer pairs and template standards for CHRM2
    OriGene qSTAR qPCR primer pairs in human, mouse for CHRM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHRM2
      QuantiTect SYBR Green Assays in human, mouse, rat CHRM2
      QuantiFast Probe-based Assays in human, mouse, rat CHRM2

    Additional mRNA sequence: 

    AF385588.1 AF498916.1 AK125233.1 AK290236.1 AL832585.1 AY034603.2 AY034604.2 AY034605.2 
    AY219703.1 AY219704.1 AY219705.1 AY456125.1 AY456126.1 AY456127.1 AY456128.1 AY456129.1 
    BC095547.1 BC106741.1 BC106742.1 

    8 DOTS entries:

    DT.121118354  DT.91838931  DT.40238607  DT.101980361  DT.101980360  DT.100019502  DT.100019504  DT.100754464 

    Selected AceView cDNA sequences (see all 28):

    AY219704 BX095847 AY456127 AY034604 AY034605 AY456126 AY219703 AY456128 
    NM_000739 BX507462 AY456125 AY456129 AY219705 AF498916 AI333530 BX483771 
    CB565881 AW084991 AY034603 N64486 AL832585 AK125233 AF385588 AI217475 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CHRM2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5
    SP1:        -     -           -     -         
    SP2:              -                           
    SP3:                                          


    ECgene alternative splicing isoforms for CHRM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHRM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGTGTGC
    CHRM2 Expression
    About this image


    CHRM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Heart (Cardiovascular System)
    CHRM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHRM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535891
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CHRM2: 
              Neurogenesis in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHRM2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrm21 , 5 cholinergic receptor, muscarinic 2, cardiac1, 5 89.38(n)1
    96.48(a)1
      6 (15.48 cM)5
    2437641  NM_203491.31  NP_987076.21 
     363880845 
    chicken
    (Gallus gallus)
    Aves CHRM21 cholinergic receptor, muscarinic 2 79.13(n)
    87.39(a)
      418126  NM_001030765.1  NP_001025936.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHRM26
    cholinergic receptor, muscarinic 2
    85(a)
    1 ↔ 1
    GL343419.1(354482-355873)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia chrm21 cholinergic receptor, muscarinic 2 75.68(n)
    83.59(a)
      100485603  XM_002942800.2  XP_002942846.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chrm2a1 cholinergic receptor, muscarinic 2a 70.4(n)
    75.11(a)
      352938  NM_178301.1  NP_840086.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mAcR-60C3 acetyl choline receptor signaling,
    muscarinic more
    55(a)   60C7   --
    worm
    (Caenorhabditis elegans)
    Secernentea M03F4.33 G-protein coupled receptor 28(a)   X(4985611-4990413)   --


    ENSEMBL Gene Tree for CHRM2 (if available)
    TreeFam Gene Tree for CHRM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHRM2 gene
    HTR2A2  DRD42  DRD22  CHRM12  HRH32  HTR2B2  HRH42  HTR2C2  
    HRH12  CHRM52  DRD32  CHRM42  CHRM32  
    Selected SIMAP similar genes for CHRM2 using alignment to 6 protein entries:     ACM2_HUMAN (see all proteins) (see all similar genes):
    CHRM4    CHRM1    OPRM1    CHRM3    HTR2A    hA2aR
    CHRM5    ADRA1A    GALR1    HTR5A    DRD3    HRH3
    HTR4    DRD5P1    MTNR1A    HRH1    HTR2C    LPAR1

    CHRM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ACM2_HUMAN, P08172: Genetic variations in CHRM2 can influence susceptibility to alcoholism [MIM:103780]


    Selected SNPs for CHRM2 (see all 2886)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3280681,2
    C,F,H--136552344(+) ctggaG/Tatata 8 -- us2k13Minor allele frequency- T:0.01NS 568
    rs105995001,2
    C--136552361(+) TATAT-/A/ATA 
            
    TATTT
    16 -- us2k1 cds10--------
    rs1996463081,2
    C--136552363(+) TATATA/TTTTTT 8 -- us2k10--------
    rs105734381,2
    C--136559771(+) GCTGA-/AT    
       
    /ATAT
    ATATA
    8 -- int11NA 2
    rs556495021,2
    C--136568506(+) TTAGT-/TGGTAA 8 -- int10--------
    rs2017851271,2
    --136615351(+) AAAAA-/ATGGATA 8 -- int10--------
    rs61503661,2
    C--136628463(-) TACTG-/TATCAATTT/TATCA
    ATTTGAAACATGATCCTG
    CCTTG
    16 -- int1 cds10--------
    rs30684171,2
    C--136629222(+) TGTGT-/GTACATG 8 -- int11Minor allele frequency- GT:0.00NA 2
    rs2019353141,2
    C--136634503(+) TTTTT-/TGGAGAC 8 -- int10--------
    rs58878201,2
    C--136641574(-) AGAGGA/-AAAAA 8 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for CHRM2 (136553399 - 136705002 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CHRM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735202CNV Deletion23290073
    nsv528311CNV Loss19592680
    nsv889235CNV Loss21882294
    nsv527148CNV Gain19592680
    nsv831147CNV Gain17160897

    Human Gene Mutation Database (HGMD): CHRM2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHRM2
    DNA2.0 Custom Variant and Variant Library Synthesis for CHRM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118493    OMIM disorders: --

    UniProtKB/Swiss-Prot: ACM2_HUMAN, P08172
  • Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait
    characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes.
    A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear
    worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional
    symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased
    energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent
    thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or
    impairment in social, occupational, or other important areas of functioning. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • Selected diseases for CHRM2 (see all 43):    
    About MalaCards
    nervous system disease    central nervous system disease    neurogenic bladder    drug dependence
    tendinosis    nicotine addiction    tendinopathy    familial dilated cardiomyopathy
    chagas disease    complex regional pain syndrome    head injury    dilated cardiomyopathy
    paine syndrome    progressive supranuclear palsy    alcohol dependence    schistosomiasis
    migraine    congestive heart failure    hyperthyroidism    major depressive disorder

    3 diseases from the University of Copenhagen DISEASES database for CHRM2:
    Schistosomiasis     Alcohol dependence     Major depressive disorder

    CHRM2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CHRM2 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dilated cardiomyopathy 45.1 9 15231368 (2), 9711178 (2), 11908781 (1), 18451336 (1) (see all 6)
    overactive bladder 36.4 1 17141942 (1)
    cardiomyopathy 36.2 4 9140822 (1), 10496197 (1), 10069511 (1), 11775829 (1)
    drug dependence 35.9 5 16000316 (2), 19644963 (1), 17567401 (1)
    bradycardia 34.4 1 12411408 (1)
    chagas disease 33.7 3 10904849 (2), 9148906 (1)
    depressive syndrome 23.1 7 15229186 (1), 16000316 (1)
    alzheimers disease 16 3 9511920 (2), 18373228 (1)
    alcoholism 14.6 14 16000316 (2), 17982586 (2), 15229186 (1), 17160701 (1) (see all 5)
    heart failure 9.76 2 11798611 (1), 16842673 (1)

    Genetic Association Database (GAD): CHRM2
    Human Genome Epidemiology (HuGE) Navigator: CHRM2 (43 documents)

    Export disorders for CHRM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHRM2 gene, integrated from 10 sources (see all 442):
    (articles sorted by number of sources associating them with CHRM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. (PubMed id 16000316)1, 4, 9 Luo X....Gelernter J. (Hum. Mol. Genet. 2005)
    2. Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. (PubMed id 19644963)1, 4, 9 Mobascher A....Winterer G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. (PubMed id 17160701)1, 4, 9 Dick D.M....Bierut L. (Behav. Genet. 2007)
    4. Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins. (PubMed id 16181410)1, 7, 9 Zuchner T....Perez-Polo J.R. (J. Neurochem. 2005)
    5. No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples. (PubMed id 19418213)1, 4, 9 Lind P.A....Martin N.G. (Behav. Genet. 2009)
    6. A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy. (PubMed id 18451336)1, 4, 9 Zhang L....Shen Y. (Circ. Res. 2008)
    7. Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk. (PubMed id 17567401)1, 4, 9 Dick D.M....Bierut L.J. (Addiction 2007)
    8. Genetic associations of brain structural networks in schizophrenia: a preliminary study. (PubMed id 20691427)1, 4 Jagannathan K....Pearlson G.D. (Biol. Psychiatry 2010)
    9. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1129 HGNC: 1951 AceView: CHRM2 Ensembl:ENSG00000181072 euGenes: HUgn1129
    ECgene: CHRM2 Kegg: 1129 H-InvDB: CHRM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHRM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHRM2 gene:
    Search GeneIP for patents involving CHRM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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