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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHRM2 Gene

protein-coding   GIFtS: 69
GCID: GC07P136553

Cholinergic Receptor, Muscarinic 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cholinergic Receptor, Muscarinic 21 2     HM22
Acetylcholine Receptor1     Acetylcholine Receptor, Muscarinic 22
Muscarinic 21     Muscarinic Acetylcholine Receptor M22
7TM Receptor2     Muscarinic M2 Receptor2

External Ids:    HGNC: 19511   Entrez Gene: 11292   Ensembl: ENSG000001810727   OMIM: 1184935   UniProtKB: P081723   

Export aliases for CHRM2 gene to outside databases

Previous GC identifers: GC07M135039 GC07P135955 GC07P136115 GC07P136010 GC07P136203 GC07P130859


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHRM2 Gene:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional
diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular
responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation.
Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The
muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac
contractility. Multiple alternatively spliced transcript variants have been described for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CHRM2 Gene: 
CHRM2 (cholinergic receptor, muscarinic 2) is a protein-coding gene. Diseases associated with CHRM2 include nervous system disease, and central nervous system disease, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Amine ligand-binding receptors. GO annotations related to this gene include G-protein coupled acetylcholine receptor activity. An important paralog of this gene is HRH4.

UniProtKB/Swiss-Prot: ACM2_HUMAN, P08172
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of
adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G
proteins. Primary transducing effect is adenylate cyclase inhibition

summary for CHRM2 Gene:
Muscarinic receptors are widely distributed throughout the body and control distinct functions according to
location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous
system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists
could prove useful in the research and treatment of a wide range of central nervous system diseases
including Alzheimer's and Parkinson's.

Gene Wiki entry for CHRM2 (Muscarinic acetylcholine receptor M2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHRM2 gene promoter:
         FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CHRM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHRM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31-q35   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q35-q36

CHRM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRM2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P136553:  view genomic region     (about GC identifiers)

Start:
136,553,399 bp from pter      End:
136,705,002 bp from pter
Size:
151,604 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 135,897,754-136,046,127     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACM2_HUMAN, P08172 (See protein sequence)
Recommended Name: Muscarinic acetylcholine receptor M2  
Size: 466 amino acids; 51715 Da
Subunit: Interacts with ARRB1 and ARRB2. Interacts with GNB2L1/RACK1; the interaction regulates CHRM2
internalization
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
membrane; Multi-pass membrane protein
2 PDB 3D structures from and Proteopedia for CHRM2:
1LUB (3D)        3UON (3D)    
Secondary accessions: Q4VBK6 Q9P1X9

Explore the universe of human proteins at neXtProt for CHRM2: NX_P08172

Explore proteomics data for CHRM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08172

  • CHRM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHRM2 Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_000730.1  NP_001006627.1  NP_001006628.1  NP_001006629.1  NP_001006630.1  NP_001006631.1  NP_001006632.1  NP_001006633.1  

    ENSEMBL proteins: 
     ENSP00000399745   ENSP00000319984   ENSP00000415386   ENSP00000384401   ENSP00000380733  
     ENSP00000384937  
    Reactome Protein details: P08172
    Human Recombinant Protein Products for CHRM2: 
    EMD Millipore Purified and/or Recombinant CHRM2 Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CHRM2
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    OriGene Custom Protein Services for CHRM2
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    Novus Biologicals CHRM2 Proteins
    Novus Biologicals CHRM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHRM2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0016021integral to membrane ----
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    CHRM2 for ontologies           About GeneDecksing



    CHRM2 Antibody Products: 
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    Assay Products for CHRM2: 
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    GenScript CHRM2-overexpressing Cell Line for Assay
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    Cloud-Clone Corp. ELISAs for CHRM2 
    Cloud-Clone Corp. CLIAs for CHRM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CHRM: GPCR / Class A : Cholinergic receptors, muscarinic
    CHR: Cholinergic receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: M2 receptor 
    Acetylcholine receptors (muscarinic)

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001065 Musac_Ach_M2_rcpt
     IPR000995 Musac_Ach_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P08172

    ProtoNet protein and cluster: P08172

    2 Blocks protein domains:
    IPB000995 Muscarinic acetylcholine receptor signature
    IPB001065 Muscarinic M2 receptor signature


    UniProtKB/Swiss-Prot: ACM2_HUMAN, P08172
    Similarity: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2
    sub-subfamily


    CHRM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACM2_HUMAN, P08172
    Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of
    adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G
    proteins. Primary transducing effect is adenylate cyclase inhibition
    Induction: Up-regulated in response to enterovirus 71 (EV71) infection

         Genatlas biochemistry entry for CHRM2:
    cholinergic receptor,muscarinic 2,G protein coupled receptor superfalily

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0016907G-protein coupled acetylcholine receptor activity IEA--
         
    CHRM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHRM2:
     Increased cell number in G2M,  

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chrm2):
     behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism  integument 
     liver/biliary system  muscle  nervous system  renal/urinary system  respiratory system 
     vision/eye 

    CHRM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CHRM2: Chrm2tm1Jwe Chrm2tm1Minm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHRM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHRM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHRM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHRM2 

    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate CHRM2 (see all 30):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-3674 hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidCHRM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHRM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRM2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CHRM2

    Clone
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    EMD Millipore Clones for the Expression of CHRM2
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    GenScript: all cDNA clones in your preferred vector (see all 8): CHRM2 (NM_001006626)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM2
    Sirion Biotech Customized lentivirus for stable overexpression of CHRM2 
                         Customized lentivirus expression plasmids for stable overexpression of CHRM2 

    Cell Line
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    GenScript CHRM2-overexpressing Cell Line for Assay
    Search LifeMap BioReagents cell lines for CHRM2
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHRM2 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Amine ligand-binding receptors0.79
    3Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5Development Angiotensin activation of ERK
    Development ACM2 and ACM4 activation of ERK0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CHRM2
        Development ACM2 and ACM4 activation of ERK


    1 GeneGo (Thomson Reuters) Pathway for CHRM2
        Development ACM2 and ACM4 activation of ERK

    5/7 BioSystems Pathways for CHRM2 (see all 7)
        Calcium Regulation in the Cardiac Cell
    SIDS Susceptibility Pathways
    GPCRs, Other
    Regulation of Actin Cytoskeleton
    GPCRs, Class A Rhodopsin-like

    5/8        Reactome Pathways for CHRM2 (see all 8)
        GPCR downstream signaling
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)
    Signal Transduction

    1 PharmGKB Pathway for CHRM2
        Antiarrhythmic Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for CHRM2):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway
    Cholinergic synapse
    Regulation of actin cytoskeleton


    CHRM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHRM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/172 Interacting proteins for CHRM2 (P081723 ENSP000003199844) via UniProtKB, MINT, STRING, and/or I2D (see all 172)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPRASP2Q96D093, ENSP000003390574I2D: score=3 STRING: ENSP00000339057
    GNA14O958373, ENSP000003658074I2D: score=1 STRING: ENSP00000365807
    GNA15P306793, ENSP000002629584I2D: score=1 STRING: ENSP00000262958
    GPRASP1Q5JY773, ENSP000003551464I2D: score=1 STRING: ENSP00000355146
    SETQ011053, ENSP000003617774I2D: score=1 STRING: ENSP00000361777
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9603968
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS10895079
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS8139539
    GO:0007207phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway TAS2739737
    GO:0007213G-protein coupled acetylcholine receptor signaling pathway ----

    CHRM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHRM2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CHRM2

    Compounds for CHRM2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (S)-(+)-Dimethindene maleateM2-selective antagonist[121367-05-3]
    Arecaidine but-2-ynyl ester tosylateMuscarinic agonist[499-04-7]
    AF-DX 384Potent M2/M4 antagonist[118290-27-0]
    AQ-RA 741 Selective, high affinity M2 antagonist [123548-16-3]
    AF-DX 116Selective M2 antagonist[102394-31-0]

    1 HMDB Compound for CHRM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    OlanzapineLanzac (see all 5)132539-06-1--

    10/61 DrugBank Compounds for CHRM2 (see all 61)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Gallamine TriethiodideBenzcurine Iodide (see all 9)65-29-2targetantagonist18305010 17944454 20083608 17588565 18552124 11752352 9007524 15937215 11426849 7522861
    DiphenidolDifenidol (see all 7)972-02-1targetantagonist12185001 8050463 1863523 10497897 10530931 9851542 9059856 9454790
    AtropineAtropin [German] (see all 5)51-55-8targetantagonist15333678 7855217 16188951 17087737 17588565 16248990
    ProcyclidineProciclidina [INN-Spanish] (see all 2)77-37-2targetantagonist2027917 17139284 20624420 1426023 17016423 2253700
    BethanecholAmidopropyldimethylbetaine (see all 7)674-38-4targetagonist16953191 17139284 17016423 11798291 17413603
    Carbachol-- 51-83-2targetagonist16181410 15333678 12505062 12948933 15485827
    FlavoxateFlavoxate HCI (see all 2)15301-69-6targetantagonist17139284 3247311 19002123 17016423 10858873
    Homatropine Methylbromide-- 80-49-9targetantagonist2612581 20085574 17139284 11124384 17016423
    OxybutyninOxibutinina [INN-Spanish] (see all 10)5633-20-5targetantagonist16188951 15963006 20590605 19446545 17222678
    Cryptenamine-- 1356-18-9targetantagonist5918523 5674398 17139284 17016423

    10/69 IUPHAR Ligands for CHRM2 (M2 receptor) (see all 69)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]QNB
    AntagonistAntagonist10.1 - 10.63443095
    NNC 11-1585
    AgonistFull agonist10.111504829
    [3H]N-methyl scopolamine
    AntagonistAntagonist6.3 - 9.99846649 11303071 12235229 16675658 9224827 7651370 7925952 7687290 16369696
    [3H](-)MQNB
    AntagonistAntagonist9.69454790
    tripitramine
    AntagonistAntagonist9.67805774
    propantheline
    AntagonistAntagonist9.512049493
    atropine
    AntagonistAntagonist7.8 - 9.211303071 12235229 3443095 16188951 12049493 2704370 9454790
    dexetimide
    AntagonistAntagonist8.99454790
    ipratropium
    AntagonistAntagonist8.811303071
    [3H]AF DX-384
    AntagonistAntagonist8.71941609

    10/68 Novoseek inferred chemical compound relationships for CHRM2 gene (see all 68)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methoctramine 86.7 7 1596672 (2), 7768300 (1), 7744887 (1), 7773550 (1) (see all 6)
    pfhhsid 86 2 2361166 (1)
    gallamine 83.9 8 9232691 (1), 17588565 (1), 17944454 (1), 15937215 (1) (see all 8)
    carbachol 81.6 16 7768300 (3), 16227319 (1), 18045877 (1), 9384504 (1) (see all 11)
    5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one 80.6 1 9214706 (1)
    pirenzepine 78.6 11 8008195 (1), 1825686 (1), 8549614 (1), 9059856 (1) (see all 9)
    hexahydrosiladifenidol 78.6 1 8549614 (1)
    6beta-acetoxynortropane 76.4 2 9622546 (1), 10375728 (1)
    himbacine 75.7 4 2401311 (1), 10712818 (1), 12628644 (1), 8564213 (1)
    atropine 70.8 4 8008195 (1), 9631949 (1), 7952627 (1), 15708029 (1)

    Search CenterWatch for drugs/clinical trials and news about CHRM2 / ACM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHRM2 gene (9 alternative transcripts): 
    NM_000739.2  NM_001006626.1  NM_001006627.1  NM_001006628.1  NM_001006629.1  NM_001006630.1  NM_001006631.1  NM_001006632.1  
    NM_001006633.1  

    Unigene Cluster for CHRM2:

    Cholinergic receptor, muscarinic 2
    Hs.535891  [show with all ESTs]
    Unigene Representative Sequence: AL832585
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445907(uc003vtf.1 uc003vtg.1) ENST00000471195 ENST00000481598
    ENST00000480591(uc003vth.1) ENST00000320658 ENST00000453373 ENST00000401861(uc003vti.1)
    ENST00000397608(uc003vtj.1 uc003vtl.1) ENST00000402486(uc003vtm.1 uc003vtk.1 uc003vtn.1 uc003vto.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate CHRM2 (see all 30):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-3674 hsa-miR-129-3p
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    Inhib. RNA
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    OriGene clones in human, mouse for CHRM2 (see all 37)
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    GenScript: all cDNA clones in your preferred vector (see all 8): CHRM2 (NM_001006626)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM2
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    Additional mRNA sequence: 

    AF385588.1 AF498916.1 AK125233.1 AK290236.1 AL832585.1 AY034603.2 AY034604.2 AY034605.2 
    AY219703.1 AY219704.1 AY219705.1 AY456125.1 AY456126.1 AY456127.1 AY456128.1 AY456129.1 
    BC095547.1 BC106741.1 BC106742.1 

    8 DOTS entries:

    DT.121118354  DT.91838931  DT.101980360  DT.101980361  DT.40238607  DT.100019502  DT.100754464  DT.100019504 

    24/28 AceView cDNA sequences (see all 28):

    AY456129 BX095847 AY219705 BX507462 AY456127 AY219704 AY456126 AY456125 
    AF498916 AY034605 AY456128 NM_000739 AY219703 AY034604 AK125233 AY034603 
    BX483771 AI333530 N64486 AL832585 AW084991 CB565881 AF385588 AI217475 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CHRM2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5
    SP1:        -     -           -     -         
    SP2:              -                           
    SP3:                                          


    ECgene alternative splicing isoforms for CHRM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHRM2 expression in normal human tissues (normalized intensities)      CHRM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGTGTGC
    CHRM2 Expression
    About this image


    CHRM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Medulla Oblongata
             ganglion/cranial/facial VII   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See CHRM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHRM2

    SOURCE GeneReport for Unigene cluster: Hs.535891
        SABiosciences Expression via Pathway-Focused PCR Arrays including CHRM2: 
              Neurogenesis in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CHRM2 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrm21 , 5 cholinergic receptor, muscarinic 2, cardiac1, 5 89.34(n)1
    96.35(a)1
      6 (15.48 cM)5
    2437641  NM_203491.31  NP_987076.21 
     363880845 
    chicken
    (Gallus gallus)
    Aves CHRM21 cholinergic receptor, muscarinic 2 78.98(n)
    87.04(a)
      418126  NM_001030765.1  NP_001025936.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHRM26
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343419.1(354482-355873)
    zebrafish
    (Danio rerio)
    Actinopterygii chrm2a1 cholinergic receptor, muscarinic 2a 69.28(n)
    73.26(a)
      352938  NM_178301.1  NP_840086.1 


    ENSEMBL Gene Tree for CHRM2 (if available)
    TreeFam Gene Tree for CHRM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHRM2 gene
    HRH42  HRH12  CHRM52  CHRM12  HRH32  CHRM42  CHRM32  
    18/21 SIMAP similar genes for CHRM2 using alignment to 6 protein entries:     ACM2_HUMAN (see all proteins) (see all similar genes):
    CHRM4    CHRM1    OPRM1    CHRM3    HTR2A    hA2aR
    CHRM5    ADRA1A    GALR1    HTR5A    DRD3    HRH3
    HTR4    DRD5P1    MTNR1A    HRH1    HTR2C    LPAR1

    CHRM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ACM2_HUMAN, P08172
    Polymorphism: Genetic variations in CHRM2 can influence susceptibility to alcoholism [MIM:103780]


    10/2886 SNPs in CHRM2 are shown (see all 2886)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3280681,2
    C,F,H--136552344(+) ctggaG/Tatata 8 -- us2k13Minor allele frequency- T:0.01NS 568
    rs105995001,2
    C--136552361(+) TATAT-/A/ATA 
            
    TATTT
    16 -- us2k1 cds10--------
    rs1996463081,2
    C--136552363(+) TATATA/TTTTTT 8 -- us2k10--------
    rs105734381,2
    C--136559771(+) GCTGA-/AT    
       
    /ATAT
    ATATA
    8 -- int11NA 2
    rs556495021,2
    C--136568506(+) TTAGT-/TGGTAA 8 -- int10--------
    rs2017851271,2
    --136615351(+) AAAAA-/ATGGATA 8 -- int10--------
    rs61503661,2
    C--136628463(-) TACTG-/TATCAATTT/TATCA
    ATTTGAAACATGATCCTG
    CCTTG
    16 -- int1 cds10--------
    rs30684171,2
    C--136629222(+) TGTGT-/GTACATG 8 -- int11Minor allele frequency- GT:0.00NA 2
    rs2019353141,2
    C--136634503(+) TTTTT-/TGGAGAC 8 -- int10--------
    rs58878201,2
    C--136641574(-) AGAGGA/-AAAAA 8 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for CHRM2 (136553399 - 136705002 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CHRM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735202CNV Deletion23290073
    nsv528311CNV Loss19592680
    nsv889235CNV Loss21882294
    nsv527148CNV Gain19592680
    nsv831147CNV Gain17160897


    Human Gene Mutation Database (HGMD): CHRM2
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CHRM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 118493    OMIM disorders: --

    UniProtKB/Swiss-Prot: ACM2_HUMAN, P08172
  • Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait
    characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes.
    A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear
    worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional
    symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased
    energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent
    thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or
    impairment in social, occupational, or other important areas of functioning. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 20/42 diseases for CHRM2 (see all 42):    About MalaCards
    nervous system disease    central nervous system disease    drug dependence    neurogenic bladder
    nicotine addiction    chagas disease    familial dilated cardiomyopathy    head injury
    dilated cardiomyopathy    complex regional pain syndrome    progressive supranuclear palsy    congestive heart failure
    major depressive disorder    hyperthyroidism    schistosomiasis    alcohol dependence
    paine syndrome    was-related disorders    alcoholism    pertussis

    3 diseases from the University of Copenhagen DISEASES database for CHRM2:
    Schistosomiasis     Alcohol dependence     Major depressive disorder

    CHRM2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/26 Novoseek inferred disease relationships for CHRM2 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dilated cardiomyopathy 45.1 9 15231368 (2), 9711178 (2), 11908781 (1), 18451336 (1) (see all 6)
    overactive bladder 36.4 1 17141942 (1)
    cardiomyopathy 36.2 4 9140822 (1), 10496197 (1), 10069511 (1), 11775829 (1)
    drug dependence 35.9 5 16000316 (2), 19644963 (1), 17567401 (1)
    bradycardia 34.4 1 12411408 (1)
    chagas disease 33.7 3 10904849 (2), 9148906 (1)
    depressive syndrome 23.1 7 15229186 (1), 16000316 (1)
    alzheimers disease 16 3 9511920 (2), 18373228 (1)
    alcoholism 14.6 14 16000316 (2), 17982586 (2), 15229186 (1), 17160701 (1) (see all 5)
    heart failure 9.76 2 11798611 (1), 16842673 (1)

    Genetic Association Database (GAD): CHRM2
    Human Genome Epidemiology (HuGE) Navigator: CHRM2 (43 documents)

    Export disorders for CHRM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHRM2 gene, integrated from 9 sources (see all 440):
    (articles sorted by number of sources associating them with CHRM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. (PubMed id 16000316)1, 4, 9 Luo X....Gelernter J. (2005)
    2. Association of a variant in the muscarinic acetylchol ine receptor 2 gene (CHRM2) with nicotine addiction. (PubMed id 19644963)1, 4, 9 Mobascher A....Winterer G. (2009)
    3. Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. (PubMed id 17160701)1, 4, 9 Dick D.M....Bierut L. (2007)
    4. Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins. (PubMed id 16181410)1, 7, 9 Zuchner T....Perez-Polo J.R. (2005)
    5. No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples. (PubMed id 19418213)1, 4, 9 Lind P.A....Martin N.G. (2009)
    6. A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy. (PubMed id 18451336)1, 4, 9 Zhang L....Shen Y. (2008)
    7. Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk. (PubMed id 17567401)1, 4, 9 Dick D.M....Bierut L.J. (2007)
    8. Genetic associations of brain structural networks in schizophrenia: a preliminary study. (PubMed id 20691427)1, 4 Jagannathan K....Pearlson G.D. (2010)
    9. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1129 HGNC: 1951 AceView: CHRM2 Ensembl:ENSG00000181072 euGenes: HUgn1129
    ECgene: CHRM2 Kegg: 1129 H-InvDB: CHRM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHRM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHRM2 gene:
    Search GeneIP for patents involving CHRM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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