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Aliases for CHRM2 Gene

Aliases for CHRM2 Gene

  • Cholinergic Receptor Muscarinic 2 2 3 5
  • Acetylcholine Receptor, Muscarinic 2 2 3
  • Muscarinic Acetylcholine Receptor M2 3
  • Cholinergic Receptor, Muscarinic 2 3
  • Muscarinic M2 Receptor 3
  • 7TM Receptor 3
  • HM2 3

External Ids for CHRM2 Gene

Previous GeneCards Identifiers for CHRM2 Gene

  • GC07M135039
  • GC07P135955
  • GC07P136115
  • GC07P136010
  • GC07P136203
  • GC07P136553
  • GC07P130859

Summaries for CHRM2 Gene

Entrez Gene Summary for CHRM2 Gene

  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHRM2 Gene

CHRM2 (Cholinergic Receptor Muscarinic 2) is a Protein Coding gene. Diseases associated with CHRM2 include Peripartum Cardiomyopathy and Neurogenic Bladder. Among its related pathways are Peptide ligand-binding receptors and Monoamine GPCRs. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled acetylcholine receptor activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for CHRM2 Gene

  • The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.

Tocris Summary for CHRM2 Gene

  • Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1 - M5).They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects.

Gene Wiki entry for CHRM2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRM2 Gene

Genomics for CHRM2 Gene

Regulatory Elements for CHRM2 Gene

Enhancers for CHRM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G136868 0.9 Ensembl ENCODE 13.4 +1.9 1872 4.5 ZNF263 MXI1 HDAC6 RNF2 SUZ12 CBX2 RAD21 ATF2 JUND SMARCA4 CHRM2 GC07P136905 GC07P136904
GH07G136953 0.9 Ensembl ENCODE 12.4 +86.7 86748 4.6 CTCF ZNF146 FOXA2 JUN RAD21 EP300 FOXA1 ZNF316 GATA2 FOS CHRM2 MIR490 KRT8P51 GC07M137079
GH07G136924 0.5 ENCODE 11.9 +56.7 56695 1.5 STAT1 GATA2 JUN FOS CHRM2 MIR490 KRT8P51
GH07G137006 0.5 ENCODE 9.8 +138.3 138333 1.3 FOS EP300 MAFK CHRM2 KRT8P51 GC07M137079
GH07G136996 0.5 ENCODE 9.6 +129.3 129326 2.0 POLR2A SMARCA4 BHLHE40 ATF2 NFE2L2 CHRM2 KRT8P51 GC07M137079
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHRM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHRM2 Gene

Chromosome:
7
Start:
136,868,652 bp from pter
End:
137,020,255 bp from pter
Size:
151,604 bases
Orientation:
Plus strand

Genomic View for CHRM2 Gene

Genes around CHRM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRM2 Gene

Proteins for CHRM2 Gene

  • Protein details for CHRM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08172-ACM2_HUMAN
    Recommended name:
    Muscarinic acetylcholine receptor M2
    Protein Accession:
    P08172
    Secondary Accessions:
    • Q4VBK6
    • Q9P1X9

    Protein attributes for CHRM2 Gene

    Size:
    466 amino acids
    Molecular mass:
    51715 Da
    Quaternary structure:
    • Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization.

    Three dimensional structures from OCA and Proteopedia for CHRM2 Gene

neXtProt entry for CHRM2 Gene

Post-translational modifications for CHRM2 Gene

  • Phosphorylated in response to agonist treatment.
  • Glycosylation at Asn2, Asn3, posLast=66, and posLast=99
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CHRM2 Gene

Domains & Families for CHRM2 Gene

Gene Families for CHRM2 Gene

Graphical View of Domain Structure for InterPro Entry

P08172

UniProtKB/Swiss-Prot:

ACM2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
genes like me logo Genes that share domains with CHRM2: view

Function for CHRM2 Gene

Molecular function for CHRM2 Gene

GENATLAS Biochemistry:
cholinergic receptor,muscarinic 2,G protein coupled receptor superfalily
UniProtKB/Swiss-Prot Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to enterovirus 71 (EV71) infection.

Gene Ontology (GO) - Molecular Function for CHRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008144 drug binding IEA --
GO:0016907 G-protein coupled acetylcholine receptor activity TAS,IDA 24256733
GO:1990763 arrestin family protein binding IPI 11566136
genes like me logo Genes that share ontologies with CHRM2: view
genes like me logo Genes that share phenotypes with CHRM2: view

Animal Models for CHRM2 Gene

MGI Knock Outs for CHRM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHRM2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHRM2 Gene

Localization for CHRM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRM2 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHRM2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CHRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IDA 24256733
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA,IEA 11566136
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CHRM2: view

Pathways & Interactions for CHRM2 Gene

genes like me logo Genes that share pathways with CHRM2: view

SIGNOR curated interactions for CHRM2 Gene

Activates:

Gene Ontology (GO) - Biological Process for CHRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006940 regulation of smooth muscle contraction IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 9603968
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 10895079
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 8139539
genes like me logo Genes that share ontologies with CHRM2: view

Drugs & Compounds for CHRM2 Gene

(231) Drugs for CHRM2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atropine Approved, Vet_approved Pharma Antagonist, antagonist, Target MAChRs antagonist 136
Bethanechol Approved Pharma Full agonist, Agonist, agonist, Target 4
Carbachol Approved Pharma Full agonist, Agonist, antagonist, Target, agonist 3
Oxybutynin Approved, Investigational Pharma Inverse agonist, Antagonist, antagonist, Target 68
Pilocarpine Approved Pharma Partial agonist, Agonist, agonist, Target 27

(29) Additional Compounds for CHRM2 Gene - From: HMDB, IUPHAR, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)aceclidine
Partial agonist, Agonist
(+)aceclidine
Full agonist, Agonist
[<sup>18</sup>F]FP-TZTP
[<sup>3</sup>H](-)MQNB
Antagonist
Gouml 7874
Negative, Allosteric regulator

(5) Tocris Compounds for CHRM2 Gene

Compound Action Cas Number
(S)-(+)-Dimethindene maleate M2-selective antagonist 136152-65-3
AF-DX 116 Selective M2 antagonist 102394-31-0
AF-DX 384 Potent M2/M4 antagonist 118290-26-9
AQ-RA 741 Selective, high affinity M2 antagonist 123548-16-3
Arecaidine propargyl ester tosylate Muscarinic agonist 147202-94-6

(65) ApexBio Compounds for CHRM2 Gene

Compound Action Cas Number
(+)-Muscarine iodide 24570-49-8
(±)-Acetylcarnitine chloride cholinergic agonist 2504-11-2
(±)-Decanoylcarnitine chloride cholinergic agonist 14919-36-9
(±)-Hexanoylcarnitine chloride cholinergic agonist 6920-35-0
(±)-Lauroylcarnitine chloride 7023-03-2
(±)-Myristoylcarnitine chloride cholinergic agonist 14919-38-1
(±)-Octanoylcarnitine chloride 18822-86-1
(±)-Propionylcarnitine chloride 18828-58-5
(R)-(+)-Tolterodine 124937-51-5
(S)-(+)-Dimethindene maleate 136152-65-3
4-DAMP 1952-15-4
5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM) 207679-81-0
5-Methylfurmethiodide 1197-60-0
Aclidinium Bromide LAMAs antagonist 320345-99-1
AF-DX 116 102394-31-0
AF-DX 384 118290-26-9
AQ-RA 741 M2 antagonist,selective and high affinity 123548-16-3
Arecaidine but-2-ynyl ester tosylate 119630-77-2
Arecaidine propargyl ester tosylate 147202-94-6
Arecoline Muscarinic acetylcholine receptors agonist 300-08-3
Arecoline hydrobromide Muscarinic receptor agonist 300-08-3
Atropine MAChRs antagonist 5908-99-6
Bethanechol chloride Muscarinic receptor agonist 590-63-6
Biperiden Anticholinergic drug 514-65-8
Biperiden HCl Anticholinergic drug 1235-82-1
Cevimeline Muscarinic receptor agonist 107233-08-9
Darifenacin HBr 133099-07-7
DAU 5884 hydrochloride 131780-48-8
Dicyclomine HCl 67-92-5
Diphenidol HCl 3254-89-5
Diphenylpyraline HCl 132-18-3
Fesoterodine Fumarate 286930-03-8
Glycopyrrolate 596-51-0
Homatropine Bromide Muscarinic AChR antagonist 51-56-9
Homatropine Methylbromide Muscarinic AChR antagonist 80-49-9
J 104129 fumarate 257603-40-0
McN-A 343 55-45-8
Mepenzolate Bromide mAChR antagonist 76-90-4
Methscopolamine Muscarinic acetylcholine receptor blocker 155-41-9
Milameline hydrochloride 139886-04-7
Nitrocaramiphen hydrochloride 98636-73-8
Oxotremorine M 3854-04-4
Oxotremorine sesquifumarate 17360-35-9
PD 102807 23062-91-1
Pirenzepine dihydrochloride 29868-97-1
Pridinol Methanesulfonate 6856-31-1
PTAC oxalate 201939-40-4
Scopolamine butylbromide 149-64-4
Scopolamine hydrobromide 114-49-8
Solifenacin hydrochloride 180468-39-7
Solifenacin succinate Muscarinic receptor antagonist 242478-38-2
Telenzepine dihydrochloride 147416-96-4
Tiotropium Bromide MAChR M antagonist 136310-93-5
Tiotropium Bromide hydrate Muscarinic antagonist 139404-48-1
Tolterodine tartrate 124937-52-6
Tropicamide Antimuscarinic drug 1508-75-4
Trospium chloride Antimuscarinic agent 10405-02-4
Umeclidinium bromide MAChR antagonist 869113-09-7
VU 0238429 1160247-92-6
VU 0255035 1135243-19-4
VU 0357017 hydrochloride 1135242-13-5
VU 0365114 1208222-39-2
VU 10010 633283-39-3
W-84 dibromide 21093-51-6
Zamifenacin fumarate 127308-98-9
genes like me logo Genes that share compounds with CHRM2: view

Drug Products

Transcripts for CHRM2 Gene

Unigene Clusters for CHRM2 Gene

Cholinergic receptor, muscarinic 2:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRM2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5
SP1: - - - -
SP2: -
SP3:

Relevant External Links for CHRM2 Gene

GeneLoc Exon Structure for
CHRM2
ECgene alternative splicing isoforms for
CHRM2

Expression for CHRM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHRM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHRM2 Gene

This gene is overexpressed in Colon - Sigmoid (x10.7), Heart - Left Ventricle (x9.1), Heart - Atrial Appendage (x7.8), and Bladder (x4.4).

Protein differential expression in normal tissues from HIPED for CHRM2 Gene

This gene is overexpressed in Urinary Bladder (51.6) and Colon (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRM2 Gene



Protein tissue co-expression partners for CHRM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHRM2 Gene:

CHRM2

SOURCE GeneReport for Unigene cluster for CHRM2 Gene:

Hs.535891

Evidence on tissue expression from TISSUES for CHRM2 Gene

  • Nervous system(4.5)
  • Heart(2)
genes like me logo Genes that share expression patterns with CHRM2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRM2 Gene

Orthologs for CHRM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRM2 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia CHRM2 34 35
  • 93.35 (n)
cow
(Bos Taurus)
Mammalia CHRM2 34 35
  • 92.97 (n)
oppossum
(Monodelphis domestica)
Mammalia CHRM2 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrm2 34 16 35
  • 89.38 (n)
rat
(Rattus norvegicus)
Mammalia LOC102551851 34
  • 89.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHRM2 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHRM2 34 35
  • 79.13 (n)
lizard
(Anolis carolinensis)
Reptilia CHRM2 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chrm2 34
  • 75.68 (n)
zebrafish
(Danio rerio)
Actinopterygii chrm2a 34 35
  • 70.4 (n)
chrm2b 35
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mAcR-60C 36 35
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea gar-3 35
  • 30 (a)
OneToMany
M03F4.3 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for CHRM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRM2 Gene

ENSEMBL:
Gene Tree for CHRM2 (if available)
TreeFam:
Gene Tree for CHRM2 (if available)

Paralogs for CHRM2 Gene

Paralogs for CHRM2 Gene

genes like me logo Genes that share paralogs with CHRM2: view

Variants for CHRM2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CHRM2 Gene

ACM2_HUMAN-P08172
Genetic variations in CHRM2 can influence susceptibility to alcoholism [MIM:103780].

Sequence variations from dbSNP and Humsavar for CHRM2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs138806839 Likely benign 137,015,979(+) AGCAG(C/G)CTGCA intron-variant, reference, missense
rs142006633 Likely benign 137,015,638(+) GCACA(A/G)CAAAA intron-variant, reference, missense
rs76394680 Likely benign 137,015,556(+) ACCCC(A/G)TTTCT intron-variant, reference, missense
rs1057518509 Uncertain significance 137,014,932(+) TTGAA(A/G)TGGTG intron-variant, reference, missense
rs138193709 Uncertain significance 137,015,725(+) CTCCA(C/G)CTCAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CHRM2 Gene

Variant ID Type Subtype PubMed ID
dgv1964e212 CNV loss 25503493
dgv1965e212 CNV loss 25503493
esv2735202 CNV deletion 23290073
esv3390664 CNV duplication 20981092
esv3412784 CNV insertion 20981092
esv3572160 CNV loss 25503493
esv3615160 CNV loss 21293372
nsv1137295 CNV deletion 24896259
nsv527148 CNV gain 19592680
nsv528311 CNV loss 19592680
nsv831147 CNV gain 17160897
nsv981586 CNV duplication 23825009

Variation tolerance for CHRM2 Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRM2 Gene

Human Gene Mutation Database (HGMD)
CHRM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHRM2

Disorders for CHRM2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CHRM2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
peripartum cardiomyopathy
  • meadows' syndrome
neurogenic bladder
  • neurogenic dysfunction of the urinary bladder
intestinal schistosomiasis
  • katayama fever
parasitic helminthiasis infectious disease
  • helminth infection
drug dependence
- elite association - COSMIC cancer census association via MalaCards
Search CHRM2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ACM2_HUMAN
  • Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. {ECO:0000269 PubMed:15229186}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for CHRM2

Genetic Association Database (GAD)
CHRM2
Human Genome Epidemiology (HuGE) Navigator
CHRM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRM2
genes like me logo Genes that share disorders with CHRM2: view

No data available for Genatlas for CHRM2 Gene

Publications for CHRM2 Gene

  1. Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. (PMID: 19644963) Mobascher A. … Winterer G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 22 46 64
  2. No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples. (PMID: 19418213) Lind P.A. … Martin N.G. (Behav. Genet. 2009) 3 22 46 64
  3. Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. (PMID: 17160701) Dick D.M. … Bierut L. (Behav. Genet. 2007) 3 22 46 64
  4. CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. (PMID: 16000316) Luo X. … Gelernter J. (Hum. Mol. Genet. 2005) 3 22 46 64
  5. Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins. (PMID: 16181410) Zuchner T. … Perez-Polo J.R. (J. Neurochem. 2005) 3 22 25 64

Products for CHRM2 Gene

  • Addgene plasmids for CHRM2

Sources for CHRM2 Gene

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