CHRM1 Gene
protein-coding GIFtS: 65
GCID: GC11M062692
|
|
cholinergic receptor, muscarinic 1
| |
Aliases
for CHRM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cholinergic Receptor, Muscarinic 11 2 | | HM12 | | M12 | | M1R2 | | Acetylcholine Receptor, Muscarinic 12 | | Muscarinic Acetylcholine Receptor M12 |
Export aliases for CHRM1 gene to outside databasesPrevious GC identifers: GC11M065188 GC11M064251 GC11M062927 GC11M062452 GC11M062453 GC11M062432 GC11M062677 GC11M059005 |
Summaries
for CHRM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHRM1:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversityof these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylatecyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influencemany effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 isinvolved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract.The gene encoding this receptor is localized to 11q13. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylatecyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primarytransducing effect is Pi turnover
 summary
for CHRM1: Muscarinic receptors are widely distributed throughout the body and control distinct functions according to
location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous
system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists
could prove useful in the research and treatment of a wide range of central nervous system diseases
including Alzheimer's and Parkinson's.
Gene Wiki entry for CHRM1 (Muscarinic acetylcholine receptor M1)
|
Genomic Views
for CHRM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHRM1 gene promoter:
NRSF form 1 c-Myb MyoD NRSF form 2 NF-kappaB1 NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHRM1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRM1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12-q13CHRM1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M062692: view genomic region
(about GC identifiers)
Start:
|
62,676,151 bp from pter |
End:
|
62,689,279 bp from pter |
Size:
|
13,129 bases |
Orientation:
|
minus strand |
|
Proteins
for CHRM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229 (See
protein sequence)Recommended Name: Muscarinic acetylcholine receptor M1 Size: 460 amino acids; 51421 Da
Subunit: Interacts with GPRASP2
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane;Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for CHRM1: NX_P11229
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P11229
CHRM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000729.2
ENSEMBL proteins: ENSP00000306490 ENSP00000441188 ENSP00000444482 Reactome Protein details: P11229
Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
CHRM1 for ontologies About GeneDecksing
CHRM1 Antibody Products:
Assay Products for CHRM1: |
Protein
Domains /
Families
for CHRM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHRM1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P11229ProtoNet protein and cluster: P11229 2 Blocks protein families: IPB000995 Muscarinic acetylcholine receptor signature IPB002228 Muscarinic M1 receptor signature
UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229Similarity: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1sub-subfamily |
Function
for CHRM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylatecyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primarytransducing effect is Pi turnover Genatlas biochemistry entry for CHRM1:cholinergic receptor,muscarinic 1,G protein coupled receptor superfamily
Clone
Products: |  | EMD Millipore Clones for the Expression of CHRM1 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHRM1 (NM_000738) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHRM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004435 | phosphatidylinositol phospholipase C activity |
TAS | 9614217 | | GO:0008144 | drug binding |
IEA | -- | | GO:0016907 | G-protein coupled acetylcholine receptor activity |
IEA | -- |
CHRM1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CHRM1:
Animal Models:
Mouse knock-outs for CHRM1: Chrm1tm2.1Stl Chrm1tm1Stl Chrm1tm1Kano Chrm1tm1Jwe Chrm1tm1Nmn
8 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Chrm1):
CHRM1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CHRM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | Regulation of Actin Cytoskeleton | | | 5 | Monoamine GPCRs | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4  BioSystems Pathways for CHRM1
5/9 
Reactome Pathways for CHRM1 (see all 9)
4 
Kegg Pathways (Kegg details for CHRM1):
CHRM1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHRM1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/134 Interacting proteins for CHRM1 (P112292, 3 ENSP000003064904) via UniProtKB, MINT, STRING, and/or I2D (see all 134)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
CHRM1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHRM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CHRM1 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for CHRM1 |
Compounds for CHRM1 available from Tocris Bioscience About this table
3 HMDB Compounds for CHRM1 About this table
10/73 DrugBank Compounds for CHRM1 (see all 73) About this table
10/49 Novoseek chemical compound relationships for CHRM1 gene (see all 49) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| iqnp |
82.5 |
3 |
7562924 (2) |
| oxotremorine m |
79.4 |
3 |
8263809 (1), 9224827 (1), 11504829 (1) |
| xanomeline |
78.7 |
3 |
9614217 (2), 17977730 (1) |
| carbachol |
78.3 |
29 |
8666061 (2), 8978936 (2), 8239269 (2), 15814109 (2) (see all 20) |
| pirenzepine |
77.8 |
13 |
8905341 (2), 10374898 (2), 9588482 (1), 7663798 (1) (see all 8) |
| acetylcholine |
71.2 |
27 |
7663798 (2), 9121346 (2), 9121347 (1), 7651370 (1) (see all 21) |
| oxotremorine |
70.7 |
6 |
8666061 (2), 2370560 (1), 1578480 (1), 7663798 (1) (see all 5) |
| brucine |
65.9 |
2 |
9224827 (2) |
| methoctramine |
64.3 |
4 |
7663798 (3), 17499370 (1) |
| tiotropium |
60.2 |
4 |
15350163 (2), 10673478 (1), 12768836 (1) |
Search CenterWatch for drugs/clinical trials and news about CHRM1 / ACM1
|
Transcripts
for CHRM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHRM1 gene: NM_000738.2 Unigene Cluster for CHRM1: Cholinergic receptor, muscarinic 1 Hs.632119 [show with all ESTs]Unigene Representative Sequence: NM_0007383 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306960(uc001nwi.3) ENST00000543973 ENST00000536524
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHRM1 (NM_000738) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHRM1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM1 |
Additional cDNA sequence: AF385587.1 AF498915.1 AJ006520.1 AK312374.1 BC007740.2 BC022984.1 BT007166.1 4 DOTS entries: DT.40120991 DT.99947477 DT.97774125 DT.95265990 24/47 AceView cDNA sequences (see all 47): CB154035 BC022984 NM_000738 AF498915 BX424634 CB154895 BI755888 BC007740 AL536991 BI757352 BX280318 CD671895 AJ006520 AI202576 BE261583 BI197683 BF315022 BM907142 BT007166 BM805220 BM805611 AI685922 BI753749 BX643235
GeneLoc Exon Structure
|
Expression
for CHRM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHRM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTCCCAGC
About this image
See CHRM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHRM1
SOURCE GeneReport for Unigene cluster: Hs.632119
SABiosciences Expression via Pathway-Focused PCR Arrays including CHRM1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRM1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHRM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRM1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM1 |
Orthologs
for CHRM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CHRM1 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
CHRM16 |
-- |
61(a) |
1 ↔ 1 |
GL344791.1(14835-16301) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7927081 |
muscarinic acetylcholine receptor M3-like |
59.28(n)
59.04(a) |
|
792708 XM_001332257.4 XP_001332293.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mAcR-60C1 , 3 |
acetyl choline receptor signaling,
muscarinic more3
muscarinic Acetylcholine Receptor 60C1 |
55(a)
(best of 2)3
63.04(n)1
57.45(a)1 |
|
60C73
378921 NM_166668.11 NP_726440.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
gar-31 |
Protein GAR-3 |
49.79(n)
44.73(a) |
|
179962 NM_001029065.1 NP_001024236.1 |
ENSEMBL Gene Tree for CHRM1 (if available)
TreeFam Gene Tree for CHRM1 (if available) |
Paralogs
for CHRM1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHRM1 gene
- HRH42 CHRM52 HRH12 CHRM22 HRH32 CHRM42 CHRM32
15 SIMAP similar genes for CHRM1 using alignment to 4 protein entries: ACM1_HUMAN (see all proteins):DRD2 CHRM4 CHRM2 CHRM3 CHRM5 HTR2B
HTR2A HTR2C HRH3 ADORA2A HTR5A SSTR5
5HT1A HTR1A hA2aR
CHRM1 for paralogs About GeneDecksing
|
Genomic Variants
for CHRM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHRM1 (62676151 - 62689279 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CHRM1
2 CNVs: 0150 47961
Human Gene Mutation Database (HGMD): CHRM1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHRM1 |
|
Disorders
/ Diseases
for CHRM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHRM1 for disorders About GeneDecksing
OMIM gene information: 118510
OMIM disorders: --
20/37  diseases for CHRM1 (see all 37): About MalaCardscentral nervous system disease nervous system disease congenital heart block attention deficit hyperactivity disorder
heart block supranuclear palsy progressive supranuclear palsy traumatic brain injury
brain injury chronic obstructive pulmonary disease nicotine dependence chronic fatigue syndrome
head injury neurodegenerative disease pulmonary disease vascular dementia
dementia sjogren's syndrome pemphigus alzheimer's disease
10/14 Novoseek disease relationships for CHRM1 gene (see all 14) About this table
Genetic Association Database (GAD): CHRM1
Human Genome Epidemiology (HuGE) Navigator: CHRM1 (19 documents)
Export disorders for CHRM1 gene to outside databases
|
Publications
for CHRM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHRM1 gene, integrated from 9 sources (see all 333):
(articles sorted by number of sources associating them with CHRM1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. (PubMed id 15383745)1, 4 Liu H.C....Tsai S.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PubMed id 15086532)1, 2 Simonin F....Kieffer B.L. (2004)
- Association of muscarinic m1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients. (PubMed id 14504414)1, 4 Liao D.L....Tsai S.J. (2003)
- Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor. (PubMed id 1445347)1, 2 Arden J.R.... Sadee W. (1992)
- Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification. (PubMed id 2336407)1, 2 Chapman C.G. and Browne M.J. (1990)
- Distinct primary structures, ligand-binding properties and tissue- specific expression of four human muscarinic acetylcholine receptors. (PubMed id 3443095)1, 2 Peralta E.G....Capon D.J. (1987)
- Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor. (PubMed id 3697105)1, 2 Allard W.J.... Dixon R.A.F. (1987)
- The presence of m1 to m5 receptors in human sclera: evidence of the sclera as a potential site of action for muscarinic receptor antagonists. (PubMed id 16877267)1, 9 Qu J....Lu F. (2006)
- Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. (PubMed id 16874522)1, 9 Lou X.Y....Li M.D. (2006)
|
External Searches for CHRM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHRM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHRM1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHRM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHRM1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CHRM1 gene:
Search GeneIP for patents involving CHRM1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHRM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CHRM1 | | OriGene shRNA RFP for CHRM1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHRM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHRM1 | | | OriGene Protein Over-expression Lysate for CHRM1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHRM1 | | OriGene 3'-UTR Clone for CHRM1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHRM1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHRM1 | | OriGene Custom Protein Services for CHRM1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHRM1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHRM1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRM1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHRM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHRM1 |
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| | | | Tocris compounds for CHRM1 |
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 | | | CHRM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM1 |
|  |  |  | | | | ThermoFisher Antibody for CHRM1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM1 |
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