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CHRM1 Gene

protein-coding   GIFtS: 68
GCID: GC11M062714

Cholinergic Receptor, Muscarinic 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cholinergic Receptor, Muscarinic 11 2     M12
Acetylcholine Receptor1     M1R2
Muscarinic 11     Acetylcholine Receptor, Muscarinic 12
HM12     Muscarinic Acetylcholine Receptor M12

External Ids:    HGNC: 19501   Entrez Gene: 11282   Ensembl: ENSG000001685397   OMIM: 1185105   UniProtKB: P112293   

Export aliases for CHRM1 gene to outside databases

Previous GC identifers: GC11M065188 GC11M064251 GC11M062927 GC11M062452 GC11M062453 GC11M062432 GC11M062677 GC11M059005 GC11M062692 GC11M062695


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHRM1 Gene:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional
diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as
adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic
receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic
cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion
of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. (provided by RefSeq, Jul
2008)

GeneCards Summary for CHRM1 Gene:
CHRM1 (cholinergic receptor, muscarinic 1) is a protein-coding gene. Diseases associated with CHRM1 include nervous system disease, and central nervous system disease. GO annotations related to this gene include drug binding and G-protein coupled acetylcholine receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of
adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G
proteins. Primary transducing effect is Pi turnover

summary for CHRM1 Gene:
Muscarinic receptors are widely distributed throughout the body and control distinct functions according to
location and subtype (M1, M2, M3, M4, M5). They are predominantly expressed in the parasympathetic nervous
system where they exert both inhibitory and excitatory effects. Muscarinic receptor agonists and antagonists
could prove useful in the research and treatment of a wide range of central nervous system diseases
including Alzheimer's and Parkinson's.

Gene Wiki entry for CHRM1 (Muscarinic acetylcholine receptor M1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHRM1 gene promoter:
         NRSF form 1   c-Myb   MyoD   NRSF form 2   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRM1 promoter sequence
   Search Chromatin IP Primers for CHRM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12-q13

CHRM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRM1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062714:  view genomic region     (about GC identifiers)

Start:
62,676,151 bp from pter      End:
62,689,279 bp from pter
Size:
13,129 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229 (See protein sequence)
Recommended Name: Muscarinic acetylcholine receptor M1  
Size: 460 amino acids; 51421 Da
Subunit: Interacts with GPRASP2

Explore the universe of human proteins at neXtProt for CHRM1: NX_P11229

Explore proteomics data for CHRM1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn2, Asn12
  • Modification sites at PhosphoSitePlus

  • See CHRM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000729.2  
    ENSEMBL proteins: 
     ENSP00000306490   ENSP00000441188   ENSP00000444482  
    Reactome Protein details: P11229

    CHRM1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CHRM1 Protein
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    OriGene Protein Over-expression Lysate for CHRM1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CHRM1
    GenScript Custom Purified and Recombinant Proteins Services for CHRM1
    Novus Biologicals CHRM1 Protein
    Novus Biologicals CHRM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHRM1

    CHRM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CHRM1
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for CHRM1
    Novus Biologicals CHRM1 Antibodies
    Abcam antibodies for CHRM1
    Cloud-Clone Corp. Antibodies for CHRM1
    ThermoFisher Antibodies for CHRM1
    LSBio Antibodies in human, mouse, rat for CHRM1

    CHRM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHRM1
    Browse R&D Systems for biochemical assays
    GenScript CHRM1-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHRM1
    Cloud-Clone Corp. CLIAs for CHRM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHRM: GPCR / Class A : Cholinergic receptors, muscarinic
    CHR: Cholinergic receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: M1 receptor
    Acetylcholine receptors (muscarinic)

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002228 Musac_Ach_M1_rcpt
     IPR000995 Musac_Ach_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P11229

    ProtoNet protein and cluster: P11229

    2 Blocks protein domains:
    IPB000995 Muscarinic acetylcholine receptor signature
    IPB002228 Muscarinic M1 receptor signature


    UniProtKB/Swiss-Prot: ACM1_HUMAN, P11229
    Similarity: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1
    sub-subfamily


    CHRM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACM1_HUMAN, P11229
    Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of
    adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G
    proteins. Primary transducing effect is Pi turnover

         Genatlas biochemistry entry for CHRM1:
    cholinergic receptor,muscarinic 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS9614217
    GO:0004930G-protein coupled receptor activity ----
    GO:0008144drug binding IEA--
    GO:0016907G-protein coupled acetylcholine receptor activity IEA--
         
    CHRM1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CHRM1:
     Decreased influenza A/WSN/33 r  Decreased viability 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Chrm1):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  nervous system  respiratory system 

    CHRM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CHRM1: Chrm1tm2.1Stl Chrm1tm1Stl Chrm1tm1Kano Chrm1tm1Jwe Chrm1tm1Nmn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHRM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHRM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHRM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHRM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHRM1:
    hsa-mir-107 (MIRT007151)

    Block miRNA regulation of human, mouse, rat CHRM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHRM1 (see all 30):
    hsa-miR-4254 hsa-miR-1321 hsa-miR-3135 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-1260b hsa-miR-3133 hsa-miR-3605-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHRM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHRM1
    Predesigned siRNA for gene silencing in human, mouse, rat CHRM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHRM1

    Clone
    Products:
         
    OriGene clones in human, mouse for CHRM1 (see all 8)
    OriGene ORF clones in mouse, rat for CHRM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHRM1 (NM_000738)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM1

    Cell Line
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    GenScript CHRM1-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHRM1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACM1_HUMAN, P11229: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    cytosol2
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane TAS7925360
    GO:0016021integral component of membrane ----

    CHRM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHRM1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Muscarinic acetylcholine receptors0.00
    Amine ligand-binding receptors0.79
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for CHRM1
        Calcium Regulation in the Cardiac Cell
    Regulation of Actin Cytoskeleton
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for CHRM1
        G alpha (q) signalling events
    Muscarinic acetylcholine receptors


    5 Kegg Pathways  (Kegg details for CHRM1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway
    Cholinergic synapse
    Regulation of actin cytoskeleton


    CHRM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CHRM1: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CHRM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHRM1 (P112292, 3 ENSP000003064904) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPRASP1Q5JY773, ENSP000003551464I2D: score=3 STRING: ENSP00000355146
    GPRASP2Q96D093, ENSP000003390574I2D: score=3 STRING: ENSP00000339057
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    AKAP5P245883I2D: score=1 
    SNX1Q135963I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS1411529
    GO:0007165signal transduction TAS3443095
    GO:0007186G-protein coupled receptor signaling pathway TAS7925360
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway TAS9603968
    GO:0007207phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway TAS8139539

    CHRM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CHRM1
      Browse compounds at ApexBio 

    Compounds for CHRM1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    McN-A 343Selective M1 muscarinic agonist[55-45-8]
    Telenzepine dihydrochloride Potent, selective M1 antagonist [147416-96-4]
    Xanomeline oxalateFunctionally selective M1 agonist[141064-23-5]
    Pirenzepine dihydrochlorideSelective M1 muscarinic antagonist[28797-61-7]
    VU 0255035Highly selective muscarinic M1 antagonist[1135243-19-4]

    3 HMDB Compounds for CHRM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    DoxylamineAlsadorm (see all 8)562-10-7--
    OlanzapineLanzac (see all 5)132539-06-1--
    Scopolamine(+)-Hyoscine (see all 38)51-34-3--

    Selected DrugBank Compounds for CHRM1 (see all 75)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TrihexyphenidylTrihexifenidilo [INN-Spanish] (see all 9)144-11-6targetantagonist2432979 17139284 1994002 11752352 17016423 3208836 18685832 17631384
    BiperidenBeperiden (see all 9)514-65-8targetantagonist10370904 17139284 11752352 17016423 10907719 9798802 8081071
    ProcyclidineProciclidina [INN-Spanish] (see all 2)77-37-2targetantagonist2027917 17139284 20624420 1426023 17016423 2253700
    PropanthelinePropantheline Bromide (see all 3)298-50-0targetantagonist3572714 2656175 11752352 17016423 15337834 16080359
    Anisotropine Methylbromide-- 80-50-2targetantagonist17139284 4555460 20391952 6897316 17016423
    OxybutyninOxibutinina [INN-Spanish] (see all 10)5633-20-5targetantagonist16406943 17139284 17016423 20590605 17222678
    Cycrimine-- 77-39-4targetantagonist1267542 17139284 11752352 17016423
    Dicyclomine-- 77-19-0targetantagonist17139284 11752352 17016423 19533734
    Doxepin-- 1668-19-5targetantagonist2141000 7855217 19179941 2329499
    EthopropazineAethopropropazin (see all 25)1094-08-2targetantagonist11752352 2904117 17016423 2236897

    Selected IUPHAR Ligands for CHRM1 (M1 receptor) (see all 66)    About this table
    LigandTypeActionAffinityPubmed IDs
    MT7
    AntagonistAntagonist11 - 11.110799315
    [3H]QNB
    AntagonistAntagonist10.6 - 10.83443095 11578621
    [3H]N-methyl scopolamine
    AntagonistAntagonist8.8 - 10.39846649 11303071 16675658 9614217 9224827 7651370 7925952 16369696 11578621
    N-methyl scopolamine
    AntagonistAntagonist9.916439611
    NNC 11-1585
    AgonistFull agonist9.911504829
    propantheline
    AntagonistAntagonist9.712049493
    atropine
    AntagonistAntagonist8.5 - 9.616439611 11303071 3443095 9029489 9614217 12049493
    ipratropium
    AntagonistAntagonist9.311303071
    4-DAMP
    AntagonistAntagonist9.21994002
    scopolamine
    AntagonistAntagonist912049493

    Selected Novoseek inferred chemical compound relationships for CHRM1 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iqnp 82.5 3 7562924 (2)
    oxotremorine m 79.4 3 8263809 (1), 9224827 (1), 11504829 (1)
    xanomeline 78.7 3 9614217 (2), 17977730 (1)
    carbachol 78.3 29 8666061 (2), 8978936 (2), 8239269 (2), 15814109 (2) (see all 20)
    pirenzepine 77.8 13 8905341 (2), 10374898 (2), 9588482 (1), 7663798 (1) (see all 8)
    acetylcholine 71.2 27 7663798 (2), 9121346 (2), 9121347 (1), 7651370 (1) (see all 21)
    oxotremorine 70.7 6 8666061 (2), 2370560 (1), 1578480 (1), 7663798 (1) (see all 5)
    brucine 65.9 2 9224827 (2)
    methoctramine 64.3 4 7663798 (3), 17499370 (1)
    tiotropium 60.2 4 15350163 (2), 10673478 (1), 12768836 (1)



    CHRM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHRM1 gene: 
    NM_000738.2  

    Unigene Cluster for CHRM1:

    Cholinergic receptor, muscarinic 1
    Hs.632119  [show with all ESTs]
    Unigene Representative Sequence: NM_000738
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306960(uc001nwi.3) ENST00000543973 ENST00000536524

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CHRM1 (see all 30):
    hsa-miR-4254 hsa-miR-1321 hsa-miR-3135 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-1260b hsa-miR-3133 hsa-miR-3605-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHRM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CHRM1
    Predesigned siRNA for gene silencing in human, mouse, rat CHRM1
    Clone
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    OriGene clones in human, mouse for CHRM1 (see all 8)
    OriGene ORF clones in mouse, rat for CHRM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHRM1 (NM_000738)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRM1
    Primer
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    OriGene qPCR primer pairs and template standards for CHRM1
    OriGene qSTAR qPCR primer pairs in human, mouse for CHRM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHRM1
      QuantiTect SYBR Green Assays in human, mouse, rat CHRM1
      QuantiFast Probe-based Assays in human, mouse, rat CHRM1

    Additional mRNA sequence: 

    AF385587.1 AF498915.1 AJ006520.1 AK312374.1 BC007740.2 BC022984.1 BT007166.1 

    4 DOTS entries:

    DT.40120991  DT.99947477  DT.97774125  DT.95265990 

    Selected AceView cDNA sequences (see all 47):

    BC007740 BX280318 BX424634 CB154895 BI755888 BI757352 AL536991 NM_000738 
    CB154035 AF498915 CD671895 BC022984 BM907142 BI913560 BI753749 AI685922 
    BX643235 BM548382 BF315022 AJ006520 AL537084 BI197683 BE261583 BT007166 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHRM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCCAGC
    CHRM1 Expression
    About this image


    CHRM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Prostate (Endocrine System)
    CHRM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHRM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632119
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CHRM1: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHRM1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrm11 , 5 cholinergic receptor, muscarinic 1, CNS1, 5 91.38(n)1
    98.91(a)1
      19 (5.44 cM)5
    126691  NM_001112697.11  NP_001106167.11 
     86637895 
    lizard
    (Anolis carolinensis)
    Reptilia CHRM16
    cholinergic receptor, muscarinic 1
    62(a)
    1 ↔ 1
    GL344791.1(14835-16301)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004904341 muscarinic acetylcholine receptor M1-like 62.54(n)
    64.68(a)
      100490434  XM_004913661.1  XP_004913718.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CU019640.16
    CHRM1 (1 of 2)6
    cholinergic receptor, muscarinic 1
    49(a)
    45(a)
    1 ↔ many
    1 ↔ many
    14(25258226-25262419) ENSDARG00000037292
    5(39363200-39364648) ENSDARG00000009121
    fruit fly
    (Drosophila melanogaster)
    Insecta mAcR-60C1 , 3 acetyl choline receptor signaling,
    muscarinic more3
    muscarinic Acetylcholine Receptor 60C1
    55(a)
    (best of 2)3
    63.75(n)1
    57.93(a)1
      60C73
    378921  NM_166668.11  NP_726440.11 
    worm
    (Caenorhabditis elegans)
    Secernentea gar-31 gar-3 50.95(n)
    46.87(a)
      179962  NM_001029065.2  NP_001024236.1 


    ENSEMBL Gene Tree for CHRM1 (if available)
    TreeFam Gene Tree for CHRM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHRM1 gene
    HTR2A2  DRD42  DRD22  CHRM22  HRH32  HTR2B2  HRH42  HTR2C2  
    HRH12  CHRM52  DRD32  CHRM42  CHRM32  
    16 SIMAP similar genes for CHRM1 using alignment to 4 protein entries:     ACM1_HUMAN (see all proteins):
    DRD2    CHRM4    CHRM2    CHRM3    CHRM5    HTR2B
    HTR2A    HTR2C    HRH3    ADORA2A    HTR5A    SSTR5
    5HT1A    HCRTR2    HTR1A    hA2aR

    CHRM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHRM1 (see all 281)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs171576281,2
    C,F,H--62675687(+) TTTTGA/GCCTAA 1 -- ds500125Minor allele frequency- N:0.00NA EA NS CSA WA 2970
    rs1848387791,2
    --62675770(+) CTGTGG/TGGTAA 1 -- ds50010--------
    rs1453207081,2
    --62676055(+) GGCCAC/TGGCCC 1 -- ds50010--------
    rs743374101,2
    C--62676056(+) GCCACA/GGCCCA 1 -- ds50010--------
    rs1884323561,2
    --62676073(+) AAAGTA/GCTTGG 1 -- ds50010--------
    rs605689771,2
    C,F--62676215(+) GAACAT/CTTGGG 1 -- ut315Minor allele frequency- C:0.14WA CSA 125
    rs1407438821,2
    --62676600(+) CTGATA/GCTTGG 1 -- ut310--------
    rs1386442791,2
    --62676774(+) TGGCTA/GTGCCC 1 -- ut310--------
    rs118237281,2
    C,F,H--62676802(+) CACACC/TGCAAT 1 -- ut31 ese317Minor allele frequency- T:0.08NS EA NA WA 2054
    rs1428470861,2
    C--62676814(+) NNNNCC/TGCTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CHRM1 (62676151 - 62689279 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CHRM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv483055CNV Loss15286789
    esv34011CNV Loss18971310

    Human Gene Mutation Database (HGMD): CHRM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHRM1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118510    OMIM disorders: --

    Selected diseases for CHRM1 (see all 33):    
    About MalaCards
    nervous system disease    central nervous system disease    congenital heart block    head injury
    progressive supranuclear palsy    vascular dementia    chronic fatigue syndrome    traumatic brain injury
    nicotine dependence    brain injury    dementia    myopia
    attention deficit hyperactivity disorder    pemphigus    pertussis    sjogren's syndrome
    schizophrenia    alzheimer's disease    bipolar disorder    asthma


    CHRM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CHRM1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cognitive disorder 50.5 2 16879488 (1)
    alzheimers disease 49 8 7816331 (3), 9109749 (1), 9869334 (1), 11718746 (1) (see all 5)
    congenital heart block 40.3 4 11247640 (2), 10402042 (2)
    schizophrenia 32 9 10822350 (2), 11384900 (2), 11153542 (1), 18033152 (1) (see all 5)
    lung diseases obstructive 19.9 1 9121347 (1)
    overactive bladder 17.3 2 16879488 (1)
    dementia 15.8 3 15059034 (2), 11718746 (1)
    neurodegenerative diseases 12.2 3 20193677 (1), 15059034 (1)
    glioma 0.592 1 8084514 (1)
    astrocytoma 0 1 1944243 (1)

    Genetic Association Database (GAD): CHRM1
    Human Genome Epidemiology (HuGE) Navigator: CHRM1 (19 documents)

    Export disorders for CHRM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHRM1 gene, integrated from 10 sources (see all 343):
    (articles sorted by number of sources associating them with CHRM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. (PubMed id 16874522)1, 4, 9 Lou X.Y....Li M.D. (Hum. Genet. 2006)
    2. Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects. (PubMed id 16931638)1, 4, 9 Maeda Y....Nishimura M. (Am. J. Respir. Crit. Care Med. 2006)
    3. Muscarinic acetylcholine receptor 1 gene polymorphisms associated with high myopia. (PubMed id 19753311)1, 4, 9 Lin H.J....Tsai F.J. (Mol. Vis. 2009)
    4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    8. Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response. (PubMed id 19183167)1, 4 Park H.W....Cho S.H. (Allergy 2009)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1128 HGNC: 1950 AceView: CHRM1 Ensembl:ENSG00000168539 euGenes: HUgn1128
    ECgene: CHRM1 Kegg: 1128 H-InvDB: CHRM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHRM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHRM1 gene:
    Search GeneIP for patents involving CHRM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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