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Aliases for CHRM1 Gene

Aliases for CHRM1 Gene

  • Cholinergic Receptor, Muscarinic 1 2 3
  • Acetylcholine Receptor, Muscarinic 1 3
  • Acetylcholine Receptor 2
  • Muscarinic 1 2
  • HM1 3
  • M1R 3
  • M1 3

External Ids for CHRM1 Gene

Previous GeneCards Identifiers for CHRM1 Gene

  • GC11M065188
  • GC11M064251
  • GC11M062452
  • GC11M062453
  • GC11M062432
  • GC11M062677
  • GC11M059005
  • GC11M062692
  • GC11M062695
  • GC11M062714

Summaries for CHRM1 Gene

Entrez Gene Summary for CHRM1 Gene

  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHRM1 Gene

CHRM1 (Cholinergic Receptor, Muscarinic 1) is a Protein Coding gene. Diseases associated with CHRM1 include congenital heart block and schizophrenia. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for CHRM1 Gene

  • The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Tocris Summary for CHRM1 Gene

  • Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1 - M5).They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects.

Gene Wiki entry for CHRM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRM1 Gene

Genomics for CHRM1 Gene

Regulatory Elements for CHRM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHRM1 Gene

Chromosome:
11
Start:
62,908,679 bp from pter
End:
62,921,861 bp from pter
Size:
13,183 bases
Orientation:
Minus strand

Genomic View for CHRM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRM1 Gene

Proteins for CHRM1 Gene

  • Protein details for CHRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11229-ACM1_HUMAN
    Recommended name:
    Muscarinic acetylcholine receptor M1
    Protein Accession:
    P11229
    Secondary Accessions:
    • Q96RH1

    Protein attributes for CHRM1 Gene

    Size:
    460 amino acids
    Molecular mass:
    51421 Da
    Quaternary structure:
    • Interacts with GPRASP2.

    Alternative splice isoforms for CHRM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHRM1 Gene

Proteomics data for CHRM1 Gene at MOPED

Post-translational modifications for CHRM1 Gene

  • Glycosylation at Asn 2 and Asn 12
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHRM1 Gene

Domains & Families for CHRM1 Gene

Gene Families for CHRM1 Gene

Graphical View of Domain Structure for InterPro Entry

P11229

UniProtKB/Swiss-Prot:

ACM1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
genes like me logo Genes that share domains with CHRM1: view

Function for CHRM1 Gene

Molecular function for CHRM1 Gene

GENATLAS Biochemistry:
cholinergic receptor,muscarinic 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Gene Ontology (GO) - Molecular Function for CHRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 9614217
GO:0004930 G-protein coupled receptor activity --
GO:0008144 drug binding IEA --
GO:0016907 G-protein coupled acetylcholine receptor activity IEA --
genes like me logo Genes that share ontologies with CHRM1: view
genes like me logo Genes that share phenotypes with CHRM1: view

Animal Models for CHRM1 Gene

MGI Knock Outs for CHRM1:

Animal Model Products

miRNA for CHRM1 Gene

miRTarBase miRNAs that target CHRM1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CHRM1 Gene

Localization for CHRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRM1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRM1 Gene COMPARTMENTS Subcellular localization image for CHRM1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CHRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane TAS 7925360
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CHRM1: view

Pathways & Interactions for CHRM1 Gene

genes like me logo Genes that share pathways with CHRM1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 1411529
GO:0007165 signal transduction TAS 3443095
GO:0007186 G-protein coupled receptor signaling pathway TAS 7925360
GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS 9603968
genes like me logo Genes that share ontologies with CHRM1: view

No data available for SIGNOR curated interactions for CHRM1 Gene

Drugs & Compounds for CHRM1 Gene

(193) Drugs for CHRM1 Gene - From: NovoSeek, IUPHAR, DGIdb, HMDB, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Darifenacin Approved, Investigational Pharma Antagonist, antagonist, Target 22
Atropine Approved Pharma Antagonist, antagonist, Target MAChRs antagonist 101
Carbachol Approved Pharma Full agonist, Agonist, antagonist, Target, agonist 3
Pilocarpine Approved Pharma Partial agonist, Agonist, agonist, Target 23
Pirenzepine Approved Pharma Antagonist, antagonist, Target 1

(25) Additional Compounds for CHRM1 Gene - From: NovoSeek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)aceclidine
Partial agonist, Agonist
(-)YM796
Partial agonist, Agonist
(+)aceclidine
Full agonist, Agonist
(plusmn)YM796
Partial agonist, Agonist
AF-DX 116
Antagonist 102394-31-0
genes like me logo Genes that share compounds with CHRM1: view

Drug Products

Transcripts for CHRM1 Gene

mRNA/cDNA for CHRM1 Gene

Unigene Clusters for CHRM1 Gene

Cholinergic receptor, muscarinic 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRM1 Gene

No ASD Table

Relevant External Links for CHRM1 Gene

GeneLoc Exon Structure for
CHRM1
ECgene alternative splicing isoforms for
CHRM1

Expression for CHRM1 Gene

mRNA expression in normal human tissues for CHRM1 Gene

mRNA differential expression in normal tissues according to GTEx for CHRM1 Gene

This gene is overexpressed in Brain - Cortex (x8.8), Brain - Frontal Cortex (BA9) (x7.2), Brain - Nucleus accumbens (basal ganglia) (x5.7), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Putamen (basal ganglia) (x5.3), Brain - Hippocampus (x4.4), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for CHRM1 Gene

This gene is overexpressed in Ovary (50.2) and Liver (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRM1 Gene



SOURCE GeneReport for Unigene cluster for CHRM1 Gene Hs.632119

genes like me logo Genes that share expression patterns with CHRM1: view

Protein tissue co-expression partners for CHRM1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CHRM1 Gene

Orthologs for CHRM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHRM1 35
  • 93.04 (n)
  • 98.91 (a)
CHRM1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRM1 35
  • 92.39 (n)
  • 98.04 (a)
CHRM1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrm1 35
  • 91.38 (n)
  • 98.91 (a)
Chrm1 16
Chrm1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHRM1 35
  • 99.86 (n)
  • 100 (a)
CHRM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrm1 35
  • 91.59 (n)
  • 98.7 (a)
oppossum
(Monodelphis domestica)
Mammalia CHRM1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHRM1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490434 35
  • 62.54 (n)
  • 64.68 (a)
zebrafish
(Danio rerio)
Actinopterygii CHRM1 (1 of 2) 36
  • 45 (a)
OneToMany
CU019640.1 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7918 37
  • 37 (a)
mAcR-60C 37
  • 55 (a)
mAcR-60C 35
  • 63.75 (n)
  • 57.93 (a)
mAcR-60C 36
  • 24 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRMAC1 35
  • 59.98 (n)
  • 55.56 (a)
worm
(Caenorhabditis elegans)
Secernentea gar-3 35
  • 50.95 (n)
  • 46.87 (a)
gar-3 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for CHRM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRM1 Gene

ENSEMBL:
Gene Tree for CHRM1 (if available)
TreeFam:
Gene Tree for CHRM1 (if available)

Paralogs for CHRM1 Gene

Paralogs for CHRM1 Gene

(16) SIMAP similar genes for CHRM1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHRM1: view

Variants for CHRM1 Gene

Sequence variations from dbSNP and Humsavar for CHRM1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1065428 -- 62,911,038(-) AAGGG(G/T)CCCTG synonymous-codon, reference
rs1065429 -- 62,910,954(-) ATCTC(C/T)TTCAA synonymous-codon, reference
rs1065431 -- 62,910,321(-) TGCTG(C/T)CGCTG synonymous-codon, reference
rs1065435 -- 62,909,934(-) TCCAC(C/G)TTCTG reference, synonymous-codon
rs1942499 -- 62,916,053(-) GCAGG(C/T)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHRM1 Gene

Variant ID Type Subtype PubMed ID
nsv483055 CNV Loss 15286789
esv34011 CNV Loss 18971310

Variation tolerance for CHRM1 Gene

Residual Variation Intolerance Score: 16.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRM1 Gene

HapMap Linkage Disequilibrium report
CHRM1
Human Gene Mutation Database (HGMD)
CHRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRM1 Gene

Disorders for CHRM1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CHRM1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
congenital heart block
  • heart block congenital
schizophrenia
  • schizophrenia 12
alzheimer disease
  • alzheimer disease, late-onset
- elite association
Search CHRM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHRM1

Genetic Association Database (GAD)
CHRM1
Human Genome Epidemiology (HuGE) Navigator
CHRM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRM1
genes like me logo Genes that share disorders with CHRM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHRM1 Gene

Publications for CHRM1 Gene

  1. Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias. (PMID: 15059034) Weiner D.M. … Brann M.R. (Am J Pharmacogenomics 2004) 23 25 26 67
  2. Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. (PMID: 10374898) Moriya H. … Hirotsu I. (Life Sci. 1999) 23 25 26 67
  3. Pharmacological characterization of human m1 muscarinic acetylcholine receptors with double mutations at the junction of TM VI and the third extracellular domain. (PMID: 9732369) Huang X.P. … Messer W.S. (J. Pharmacol. Exp. Ther. 1998) 23 25 26 67
  4. A conserved motif in the membrane proximal C-terminal tail of human muscarinic m1 acetylcholine receptors affects plasma membrane expression. (PMID: 19841475) Sawyer G.W. … Shults C.A. (J. Pharmacol. Exp. Ther. 2010) 23 67
  5. Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells. (PMID: 19927300) Reina S. … Borda E. (J. Cell. Physiol. 2010) 23 67

Products for CHRM1 Gene

Sources for CHRM1 Gene

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